56,151 results match your criteria Fibrous Cortical Defect


Malignant solitary fibrous tumor of the kidney with liver metastasis: A case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1217-S1219

Department of Medical Imaging, Shanghai Gongli Hospital, Shanghai 200135, China.

Solitary fibrous tumor (SFT) is a rare spindle cell soft tissue tumor which is rarely encountered in the clinical setting and imaging findings are nonspecific, mainly occurring in the tissue structure of the serosa. However, there is very little report on SFT originating in the kidney in the medical literature. We report a case of SFT with liver metastasis in an adult female and discuss the pathological features as it appears in our case. Read More

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December 2018

What abdominal radiologists should know about extragenital endometriosis-associated neuropathy.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, Hospital Sírio-Libanês, Adma Jafet, 91, Bela Vista, São Paulo, SP, 01308-050, Brazil.

Purpose: The aim of this study is to provide an overview of endometriosis-associated neuropathy and to review main anatomical concepts of intrapelvic peripheral nerves.

Methods: In this pictorial essay, we review the anatomy of pelvic nerves and imaging features of endometriosis-associated neuropathy. We also evaluate clinical findings, imaging features, and outcome of seven patients with endometriosis-associated neuropathy. Read More

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December 2018
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Unusual bilateral ureter strangulation by fibrous tissue after perineal hernia repair in a dog.

Open Vet J 2018 19;8(4):441-444. Epub 2018 Nov 19.

Hokkaido University Veterinary Teaching Hospital, Kita 19, Nishi 10, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

A 10-year-old castrated male cross-breed dog was referred for the repair of perineal hernia with bladder retroflexion and a mass lesion in the hernial sac. Surgical treatment was performed and the mass was identified as degenerated adipose tissue that was suspected to be derived from the omentum. The hernial contents were reduced without difficulty, and the dog exhibited a normal recovery. Read More

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November 2018

First two cases of craniomaxillofacial fibrous dysplasia from Nepal - case series.

Clin Cosmet Investig Dent 2018 26;10:269-274. Epub 2018 Nov 26.

Department of Oral and Maxillofacial Surgery, Chitwan Medical College and Teaching Hospital, Bharatpur-10, Chitwan, Nepal.

Fibrous dysplasia is a benign fibro-osseous disease of the bone, which is most commonly associated with congenital mutations in cAMP regulating protein Gsα coded by gene. Often it is seen involving the craniofacial skeleton and can range from an asymptomatic monostotic form to polyostotic variant involving almost all the bones of the skull, thereby leading to functional and esthetic problems. This requires a continuous monitoring of the involved region throughout the life of the patient, even after the surgical interventions. Read More

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November 2018

Giant fenestration and fibrous strand rupture of aortic valve without massive regurgitation.

J Cardiol Cases 2012 Jun 11;5(3):e163-e165. Epub 2012 May 11.

Tokyo Heart Center, Department of Cardiovascular Surgery, Tokyo, Japan.

We present a case of a giant fenestration and a fibrous strand rupture of the aortic valve without massive regurgitation. A 56-year-old woman, was referred for coronary revascularization, had II-III degree aortic regurgitation without symptoms of heart failure. On the intraoperative direct view, the non coronary cusp (NCC) had the giant fenestration and the left coronary cusp (LCC) had the fibrous strand rupture. Read More

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Ruptured plaque in a bare-metal stent 8 years after implantation-Comparison of IVUS and OCT findings.

J Cardiol Cases 2012 Feb 2;5(1):e1-e3. Epub 2011 Oct 2.

Division of Cardiology, Nagoya City East Medical Center, 1-2-23 Wakamizzu-cho, Chikusa-ku, Nagoya 464-8547, Japan.

Optical coherence tomography (OCT) and intravascular ultrasound tomography (IVUS) findings in a patient with very late in-stent restenosis that was manifested as acute coronary syndrome 8 years after bare-metal stent implantation are presented. This case clearly shows the disruption of thin fibrous cap associated with a white thrombus by OCT. A superficial high signal with deep attenuation by OCT, composing more than half of the plaque, was expressed as heterogeneous tissue, mainly composed of echolucent lesion including outside the struts by IVUS. Read More

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February 2012

Observation of short-term atorvastatin-induced changes in coronary arterial plaque properties using integrated backscatter intravascular ultrasound in a patient.

J Cardiol Cases 2011 Jun 21;3(3):e111-e114. Epub 2011 Apr 21.

Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima 770-8503, Japan.

Integrated backscatter intravascular ultrasound (IB-IVUS) capable of assessing plaque properties has recently become clinically applicable. We observed short-term atorvastatin-induced changes in coronary arterial plaque properties using IB-IVUS. The patient was a 57-year-old man who underwent coronary angiography when admitted to our hospital for cerebrovascular surgery, and lesions were observed in 2 branches: 99% and 90% stenoses in the proximal anterior descending branch (LAD) and middle region of the circumflex, respectively. Read More

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Persistence of a pacemaker lead-like "ghost" 6 months after lead extraction.

Echocardiography 2018 Dec 9. Epub 2018 Dec 9.

Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

Residual fibrous structures, referred as "ghosts", are occasionally encountered following lead extraction. Though typically detected in patients with cardiac device infections, their prognostic and therapeutic implications remain speculative. We describe a 62-year-old gentleman with history of sick sinus syndrome who presented atrial fibrillation with rapid ventricular response. Read More

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December 2018

Oral health-related quality of life in patients with disorders of nutrition.

J Oral Rehabil 2018 Dec 11. Epub 2018 Dec 11.

Department of Community Dentistry, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

Background: Researchers demonstrated a correlation between nutrition and health-related quality-of-life (HRQoL). Little is known about the correlation between disorders of nutrition (DON) and Oral HRQoL (OHRQoL).

Objectives: 1) to measure OHRQoL in DON patients compared to patients attending nutritional counseling for other reasons (e. Read More

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December 2018
1.934 Impact Factor

Anatomically Based Optimization of Outcomes in Middle Eastern Rhinoplasy.

Plast Reconstr Surg Glob Open 2018 Oct 22;6(10):e1862. Epub 2018 Oct 22.

Faculty of Medicine, Menoufia University, Egypt.

Background: The predominant character in the Middle Eastern noses is the thick skin, weak cartilages, amorphous bulbous nasal tip, and high incidence of postoperative supra-tip swelling, compared with the Caucasian noses. The purpose of this study was to describe some anatomical findings and find techniques to improve outcomes in these patients.

Methods: This is retrospective study in 624 patients of Middle Eastern origin, where the characteristic anatomical findings are described and the surgical endeavors to combat their detrimental effect on the outcomes of rhinoplasty are explained. Read More

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October 2018

Analysis of bone osteometry, mineralization, mechanical and histomorphometrical properties of tibiotarsus in broiler chickens demonstrates a influence of dietary chickpea seeds (Cicer arietinum L.) inclusion as a primary protein source.

PLoS One 2018 11;13(12):e0208921. Epub 2018 Dec 11.

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.

This study was focused on analyzing the effects of dietary inclusion of raw chickpea seed as a replacement of soybean meal as a primary protein source on bone structure in broiler chickens. Broiler chickens (n = 160) received in their diet either soybean meal (SBM) or raw chickpea seeds (CPS) as a primary protein source throughout the whole rearing period (n = 80 in each group). On the 42th day randomly selected chickens from each group (n = 8) were slaughtered. Read More

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December 2018

[A case of cholangiolocellular carcinoma found to be hepatic hemangioma at 16-month follow up].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1078-1086

Department of Gastroenterology, Matsushita Memorial Hospital.

We report a rare case of hepatic cholangiolocellular carcinoma (CoCC) with long-term observation. A 73-year-old woman was found to have a solitary hepatic tumor with a diameter of 10mm on dynamic computed tomography (CT), which showed peripheral enhancement in the arterial phase and enhancement retention in the delayed phase. Although it was initially diagnosed as hepatic hemangioma, the follow up examination conducted 16 months later revealed that the tumor had grown to 18mm. Read More

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January 2018

A 3D printed PCL/hydrogel construct with zone-specific biochemical composition mimicking that of the meniscus.

Biofabrication 2018 Dec 7. Epub 2018 Dec 7.

Biological Sciences, METU, Ankara, TURKEY.

Engineering the meniscus is challenging due to its bizonal structure; the tissue is cartilaginous at the inner portion and fibrous at the outer portion. Here, we constructed an artificial meniscus mimicking the biochemical organization of the native tissue by 3D printing a meniscus shaped PCL scaffold and then impregnating it with agarose (Ag) and gelatin methacrylate (GelMA) hydrogels in the inner and outer regions, respectively. After seeding the constructs with porcine fibrochondrocytes and incubating for 8 weeks, we demonstrated that presence of Ag enhanced glycosaminoglycan (GAG) production by about 4 fold (p<0. Read More

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December 2018

Expression of Mac-2 binding protein in human carotid atheroma is associated with plaque instability and clinical manifestations.

Biomed Pharmacother 2018 Dec 5;110:465-472. Epub 2018 Dec 5.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:

Background: Mac-2 binding protein (M2BP) is a proinflammatory protein associated with atherosclerosis and prognosis in patients with coronary artery diseases. We aimed to investigate the expression of M2BP in human carotid plaques and its relation to clinical symptoms and components within plaques.

Methods: Patients (n = 51) undergoing carotid endarterectomy were consecutively recruited in our study. Read More

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December 2018

A functionalized nano-structured cellulosic sorbent aerogel for oil spill cleanup: Synthesis and characterization.

J Hazard Mater 2018 Nov 23;366:229-239. Epub 2018 Nov 23.

Catalysis and Nanostructured Materials Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155/4563, Tehran, Iran; Oil and Gas Center of Excellence, University of Tehran, P.O. Box 11155/4563, Tehran, Iran.

A new synthesis strategy was adopted to convert cellulose to a biodegradable sorbent with properties of very high oil absorption and retention capacities, excellent oil-water selectivity, good mechanical strength and recycling ability. The sorbent in form of a hydrophobic/oleophilic nano-structured aerogel was prepared through functionalizing cotton cellulose with low surface energy moieties followed by dissolving and chemically cross-linking the product in an organic medium (DMSO), and freeze-drying. High absorption capacities of 40. Read More

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November 2018
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Microplastic abundance, distribution and composition in water, sediments, and wild fish from Poyang Lake, China.

Ecotoxicol Environ Saf 2018 Dec 5;170:180-187. Epub 2018 Dec 5.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan 430074, China. Electronic address:

Microplastic pollution in global aquatic environments has aroused increasing concern in recent years. In this study, the occurrence of microplastics in multiple environmental compartments was investigated in Poyang Lake, the largest freshwater lake of China. The abundance of microplastics was respectively 5-34 items/L for surface waters, 54-506 items/kg for sediments, and 0-18 items per individual for wild crucians (Carassius auratus). Read More

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December 2018

Infantile myofibromatosis: review of imaging findings and emphasis on correlation between MRI and histopathological findings.

Clin Imaging 2018 Nov 8;54:40-47. Epub 2018 Nov 8.

Diagnostic Radiology Department, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, 1107 2020 Beirut, Lebanon. Electronic address:

Background: Infantile myofibromatosis (IM) is the most common fibrous tumor of infancy. MRI is considered the gold standard in IM evaluation. Very little has been published about IM with histopathology correlation in the pediatric age. Read More

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November 2018

Machine-learning integration of CT histogram analysis to evaluate the composition of atherosclerotic plaques: Validation with IB-IVUS.

J Cardiovasc Comput Tomogr 2018 Oct 21. Epub 2018 Oct 21.

Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Background: To determine whether machine learning with histogram analysis of coronary CT angiography (CCTA) yields higher diagnostic performance for coronary plaque characterization than the conventional cut-off method using the median CT number.

Methods: We included 78 patients with 78 coronary plaques who had undergone CCTA and integrated backscatter intravascular ultrasound (IB-IVUS) studies. IB-IVUS diagnosed 32 as fibrous- and 46 as fatty or fibro-fatty plaques. Read More

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October 2018

Activity of axitinib in progressive advanced solitary fibrous tumour: Results from an exploratory, investigator-driven phase 2 clinical study.

Eur J Cancer 2018 Dec 5;106:225-233. Epub 2018 Dec 5.

Medical Oncology Unit 2, Medical Oncology Department, Fondazione IRCCS Istituto Nazione dei Tumori, Milan, Italy; Medical Oncology and Hemato-Oncology Department, University of Milan, Milano, Italy.

Background: To explore the activity of axitinib in advanced solitary fibrous tumour (SFT).

Patients And Methods: In this investigator-driven phase II study on axitinib in advanced and progressive SFT, patients received axitinib, 5 mg bis in day (BID), until progression or limiting toxicity. Pathologic diagnosis was centrally reviewed, distinguishing malignant SFT (M-SFT) and high-grade/dedifferentiated SFT (HG/D-SFT) subtypes. Read More

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December 2018

Evaluation of teriparatide effect on healing of autografted mandibular defects in rats.

J Craniomaxillofac Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Biostatistics and Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: To evaluate the effects of short-term teriparatide administration on healing of autologous bone graft in mandibular critical-size defects.

Subjects And Methods: A 5-mm mandibular bone defect was created and iliac bone graft was harvested in 135 rats. Rats were randomly divided into 3 groups of negative control (NC), control (C), and study (S). Read More

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November 2018

Scedosporium apiospermum invasive sinusitis presenting as extradural abscess.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

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December 2018

Treatment of spinal malignant fibrous histiocytoma, a case report and literature review.

Neurocirugia (Astur) 2018 Dec 7. Epub 2018 Dec 7.

Neurocirugía, Hospital General Naval de Alta Especialidad de la Secretaría de Marina (HOSGENAES SEMAR), Delegación Coyoacán, Ciudad de México, México.

Objective: To present a case of spinal malignant fibrous histiocytoma in the fourth lumbar vertebra that received treatment by an L4 spondylectomy and placement of intervertebral expander and posterior fixation.

Case Report: A 47-year-old male patient with no relevant history presented with lumbar pain of 2 months' evolution. Treated conservatively, with slight improvement in pain, the patient persisted with low back pain irradiation to pelvic members, predominantly left-sided, accompanied by weakness and claudication. Read More

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December 2018
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Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma.

Lung Cancer 2018 Dec 28;126:64-71. Epub 2018 Oct 28.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. Electronic address:

Objectives: Podoplanin-positive cancer-associated fibroblasts [PDPN (+) CAFs] play an important role in cancer progression in non-small-cell lung cancer. The aim of this study was to clarify the correlation between a fibrous microenvironment containing PDPN (+) CAFs and an immune microenvironment.

Materials And Methods: A total of 174 patients with pathological stage I lung adenocarcinoma were analyzed. Read More

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December 2018

Cardiovascular images: vascular hamartoma of the mitral valve in a horse.

J Vet Cardiol 2018 Dec 18;20(6):399-404. Epub 2018 Oct 18.

Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA. Electronic address:

An 8-month-old Hanoverian gelding was presented with a history of cardiac murmurs that were not apparent as a foal nor reported at the time of castration. Major echocardiographic findings included mitral valvular thickening, functional stenosis, and mitral regurgitation of sufficient severity to cause diastolic and systolic cardiac murmurs, left-sided volume overload, and pulmonary hypertension. Due to the hemodynamic severity of the lesion and poor prognosis for future performance and longevity, euthanasia was elected. Read More

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December 2018

Myofascial Pain.

Semin Neurol 2018 Dec 6;38(6):640-643. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

Myofascial pain syndromes arise from acute and chronic musculoskeletal pain and often have a referred neuropathic component. It affects more than three quarters of the world's population and is one of the most important and overlooked causes of disability. The origins of pain are thought to reside anywhere between the motor end plate and the fibrous outer covering of the muscle, with involvement of microvasculature and neurotransmitters at the cellular level. Read More

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December 2018
5 Reads

A Rare Diagnosis After the Fall of a 96-Year-Old Woman: Doege-Potter Syndrome.

Curr Aging Sci 2018 Dec 5. Epub 2018 Dec 5.

Acute Geriatrics Unit, Monza (MB). Italy.

Introduction: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2).

Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More

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December 2018

HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.

Transpl Immunol 2018 Dec 1. Epub 2018 Dec 1.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.

Background: Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown.

Methods: A murine heterotopic tracheal transplantation model was used. Protein concentrations of HMGB1, interferon-γ (IFN-γ), interleukin (IL)-10, and IL-17 were analyzed in the isografts, allografts, controls, and HMGB1-neutralizing antibody administered allografts (n = 6; Days 1, 3, 5, 7, 14, 21, and 28). Read More

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December 2018
2 Reads

Development and evaluation of multistructured and hierarchical epidermal growth factor-poly (ε-caprolactone) scaffolds.

IEEE Trans Nanobioscience 2018 Nov 30. Epub 2018 Nov 30.

In this study, we separately fabricated the poly (ε-caprolactone) (PCL) scaffolds containing epidermal growth factor (EGF) by using our-self fabricated electrospinning machine for tissue regeneration application. Several fundamental properties, including the dimensions, wettability and EGF release profiles, of the fabricated EGF-PCL the bead, fibrous and multistructured scaffolds were characterised by using the Scanning Electron Microscopy (SEM), contact angle goniometer and vertical diffusion system. The EGF release profiles of three scaffolds were measured for 200 hours and the multistructured scaffold performed stable and long EGF release properties. Read More

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November 2018
2 Reads

Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation.

J Mater Sci Mater Med 2018 Nov 30;29(12):182. Epub 2018 Nov 30.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, Estonia.

3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. Read More

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November 2018
4 Reads

Large adipose tissue generation in a mussel-inspired bioreactor of elastic-mimetic cryogel and platelets.

J Tissue Eng 2018 Jan-Dec;9:2041731418808633. Epub 2018 Nov 14.

Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Soft tissue generation, especially in large tissue, is a major challenge in reconstructive surgery to treat congenital deformities, posttraumatic repair, and cancer rehabilitation. The concern is along with the donor site morbidity, donor tissue shortage, and flap necrosis. Here, we report a dissection-free adipose tissue chamber-based novel guided adipose tissue regeneration strategy in a bioreactor of elastic gelatin cryogel and polydopamine-assisted platelet immobilization intended to improve angiogenesis and generate large adipose tissue in situ. Read More

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November 2018
2 Reads

Intraspinal Dissemination and Local Recurrence of an Intracranial Hemangiopericytoma: Case Report.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Hemangiopericytomas (HPCs) are rare vascular tumors that resemble meningiomas on imaging and have a high rate of local recurrence and metastases. There remains a paucity of data to guide management decisions of intraspinal dissemination of HPC in the literature, and none specifically related to anaplastic HPCs.

Case Description: Case report of a 34-year-old female with locally and distantly recurrent anaplastic hemangiopericytoma (HPC) (WHO grade III). Read More

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November 2018
1 Read

Fine structure of the silk gland in the mite Ornithocheyletia sp. (Prostigmata, Cheyletidae).

J Morphol 2018 Dec 5. Epub 2018 Dec 5.

Zoological Institute, Russian Academy of Sciences, Saint-Petersburg, Russia.

Silk spinning is widely-spread in trombidiform mites, yet scarse information is available on the morphology of their silk glands. Thus this study describes the fine structure of the prosomal silk glands in a small parasitic mite, Ornithocheyletia sp. (Cheyletidae). Read More

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December 2018
1 Read

Mediastinal teratoma presenting with hemoptysis and pleuritis misdiagnosed as tuberculosis (empyema).

BMC Pediatr 2018 Dec 4;18(1):382. Epub 2018 Dec 4.

Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Nanlishi Road 56, Xicheng District, Beijing, People's Republic of China.

Background: Mediastinal teratoma is uncommon in children. It can be very difficult to diagnose especially in early stage. Rarely, teratoma may rupture into adjacent structures and lead to lung lesions or pleuritis. Read More

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December 2018
2 Reads

Solitary fibrous tumor of central nervous system masquerading as meninigioma: Report of a rare case.

Int J Surg Case Rep 2018 Nov 27;54:10-14. Epub 2018 Nov 27.

Deptt. of Pathology, PGIMS Rohtak, Haryana, India. Electronic address:

Introduction: Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin that occurs most often in the visceral pleura. It rarely occurs in the central nervous system (CNS). If they occur intracranially, they are extra-axially located and develop from the meninges. Read More

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November 2018
1 Read

Facile fabrication of superporous and biocompatible hydrogel scaffolds for artificial corneal periphery.

Colloids Surf B Biointerfaces 2018 Nov 8;175:26-35. Epub 2018 Nov 8.

Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan. Electronic address:

Biocompatible and highly porous network hydrogel scaffolds were fabricated for the development of artificial cornea (AC) periphery/skirt that could be used to enhance the long-term retention of the implants. In this study, a series of hydrogel scaffolds for this application was fabricated from the photo-polymerization of a mixture of poly(ethylene glycol) (PEG)- and poloxamer (P407)-based macromer solutions in dichloromethane in which solvent-induced phase separation (SIPS) arose to form scaffolds with macroporous structure and high water content. The overall porosity ranging from 20% to 75% and open/closed pore structure of the hydrogel scaffolds could be finely tuned by varying the ratio of P407/PEG in the macromer solution and solvent type. Read More

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November 2018
6 Reads

State of the art in magnetic resonance imaging of hepatocellular carcinoma.

Radiol Oncol 2018 Nov 26;52(4):353-364. Epub 2018 Nov 26.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.

Background Liver cancer is the sixth most common cancer worldwide and the second leading cause of cancer mortality. Chronic liver disease caused by viral infection, alcohol abuse, or other factors can lead to cirrhosis. Cirrhosis is the most important clinical risk factor for hepatocellular carcinoma (HCC) whereby the normal hepatic architecture is replaced by fibrous septa and a spectrum of nodules ranging from benign regenerative nodules to HCC, each one of them with different imaging features. Read More

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November 2018
2 Reads

Amorphous-to-crystalline transformation toward controllable synthesis of fibrous covalent organic frameworks enabling promotion of proton transport.

Chem Commun (Camb) 2018 Dec 4. Epub 2018 Dec 4.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200433, P. R. China.

Reversible imine exchange is adopted to molecularly re-arrange polyazomethine-based amorphous fibers into covalent organic frameworks (COFs) retaining pristine fibrous characters with periodic and oriented micropore channels. Such fibrous COFs can immobilize the assembled Nafion to form long-range proton conduction pathways, thus largely promoting proton transport. Read More

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December 2018
3 Reads

FSIP1 regulates autophagy in breast cancer.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Fibrous sheath interacting protein 1 (FSIP1) is a cancer antigen expressed in the majority of breast cancer tissues and is associated with poor prognosis. However, the role of FSIP1 in the progression and drug sensitivity of triple-negative breast cancer (TNBC) has not been explored. Here, we show that FSIP1 deficiency by shRNA-mediated knockdown or CRISPR-Cas9-mediated knockout significantly inhibits the proliferation and invasion of TNBC cells and impairs chemotherapy-induced growth inhibition in vivo. Read More

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December 2018
1 Read

Evaluation of texture features at staging liver fibrosis based on phase contrast X-ray imaging.

Biomed Eng Online 2018 Dec 3;17(1):179. Epub 2018 Dec 3.

Department of Medical Physics, School of Foundational Education, Peking University Health Science Center, Beijing, 100191, China.

Background: The purpose of this study is to explore the potential of phase contrast imaging to detect fibrotic progress in its early stage; to investigate the feasibility of texture features for quantified diagnosis of liver fibrosis; and to evaluate the performance of back propagation (BP) neural net classifier for characterization and classification of liver fibrosis.

Methods: Fibrous mouse liver samples were imaged by X-ray phase contrast imaging, nine texture measures based on gray-level co-occurrence matrix were calculated and the feasibility of texture features in the characterization and discrimination of liver fibrosis at early stages was investigated. Furthermore, 36 or 18 features were applied to the input of BP classifier; the classification performance was evaluated using receiver operating characteristic curve. Read More

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December 2018
2 Reads

Digestate mechanical separation: Efficiency profiles based on anaerobic digestion feedstock and equipment choice.

Bioresour Technol 2018 Nov 26;274:180-189. Epub 2018 Nov 26.

LBE, INRA, Univ Montpellier, 102 avenue des Etangs, 11100 Narbonne, France.

Digestate mechanical separation is present in numerous anaerobic digestion plants. In this study, data from literature and from unpublished analysis were gathered to evaluate digestate separation efficiency for different mechanical separators. For the first time, efficiency indicators allowed the definition of two mass distribution profiles. Read More

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November 2018
1 Read

Stokes mode Raman random lasing in a fully biocompatible medium.

Opt Lett 2018 Dec;43(23):5865-5868

We demonstrate for the first time, to the best of our knowledge, Raman random lasing in a continuous-wave (CW) excited, completely biocompatible and biodegradable carrot medium naturally composed of fibrous cellulose scattering medium and rich carotene Raman gain medium. The CW-laser-induced photoluminescence threshold and linewidth analysis at the Stokes modes of carotene show a characteristic lasing action with a threshold of 130  W/cm and linewidth narrowing with mode Q factor up to 1300. Polarization study of output modes reveals that lasing mode mostly retains the source polarization state. Read More

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December 2018
1 Read

Solitary fibrous tumor/hemangiopericytoma of the optic canal.

Clin Neuropathol 2018 Nov 30. Epub 2018 Nov 30.

Solitary fibrous tumor/hemangiopericytoma seldom arises from the optic nerve sheath. Herein, we describe the clinical, radiological, and histological findings of a solitary fibrous tumor/hemangiopericytoma arising from the optic nerve sheath and occupying the optic canal. The diagnosis is challenging both clinically and histologically as it clinically simulates a commoner lesion, i. Read More

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November 2018
1 Read

[New biophotonics methods for improving efficiency and safety of laser modification of the fibrous tunic of the eye].

Vestn Oftalmol 2018 ;134(5):4-14

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021; I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.

The article describes a newly developed and tested diffractive optical element (DOE) that converts non-uniform radiation of the laser output into a homogeneous ring. The Gerchberg-Saxton algorithm is shown to be well suited for achieving annular intensity distribution. Testing this ring transducer on threshold-plasticity cornea demonstrated the reversibility of axisymmetric changes in the cornea. Read More

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January 2018

Surgery for advanced non-small cell lung cancer patient after epidermal growth factor receptor tyrosine kinase inhibitor neoadjuvant therapy.

Ann Transl Med 2018 Oct;6(20):407

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Background: This study aimed to evaluate the survival of the advanced non-small cell lung cancer (NSCLC) patients underwent salvage surgeries after EGFR-TKI neoadjuvant therapies.

Methods: From 2014 to 2016, 10 patients diagnosed as advanced stage NSCLC (N2 metastasis or great vessels invasion) who responded to EGFR-TKI neoadjuvant therapy were recruited in this study. All patients underwent surgeries and consented the follow-up study. Read More

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October 2018
3 Reads

Spinal Endoscopy for Delayed-Onset Lumbar Radiculopathy Resulting from Foraminal Stenosis after Osteoporotic Vertebral Fracture: A Case Report of a New Surgical Strategy.

Case Rep Orthop 2018 25;2018:1593021. Epub 2018 Oct 25.

Department of Orthopedic Surgery, Wakayama Medical University, Japan.

There is little evidence regarding the optimal approach to treatment for delayed-onset lumbar radiculopathy due to foraminal stenosis after osteoporotic vertebral fracture. Here, we describe the use of spinal endoscopy for the treatment of this disabling condition, in an 80-year-old woman presenting with severe radicular pain following an osteoporotic lumbar compression fracture. Radiographic findings showed the compression of the L2 root within the foramen, and computed tomography identified a fragment of the posterior wall of the vertebral body under the pedicle. Read More

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October 2018
1 Read

Hyalinizing trabecular tumor of the thyroid gland with transcapsular invasion: a case report.

Cesk Patol 2018 ;63(4):191-194

Hyalinizing trabecular tumor is a rare neoplasm usually with benign clinical behavior. Exceptionally it shows characteristic features of malignant tumors, such as the presence of venous or capsular invasion or distant metastasis. We report the case of 45-years-old female with a palpable nodule in the right lobe of the thyroid gland, 8x8x10 mm in size, well circumscribed, white colored. Read More

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January 2018
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Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.

J Bone Miner Res 2018 Nov 29. Epub 2018 Nov 29.

Skeletal Disorders and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α-subunit of the G stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile lesions of fibrotic tissue and abnormal bone. Local bone remodeling regulation by BMSCs is also altered, and FD tissue is characterized by abundant osteoclast-like cells that may be essential for lesion expansion. Read More

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November 2018
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