Search Our Scientific Publications & Authors

J Orthop Sports Phys Ther 2018 Oct;48(10):823

An 18-year-old woman presented to a direct-access military physical therapy clinic after a fall directly onto the knee, with subsequent medial knee pain. The history and examination of the patient led the physical therapist to order radiographs, which revealed a pre-existing metaphyseal fibrous defect. On the same day, an orthopaedic consultation recommended magnetic resonance imaging and computed tomography, which showed a progression from a benign cortical defect to disruption of the posterior femur and surrounding bone marrow edema consistent with bone stress injury. Read More

Adv Healthc Mater 2018 Aug 27;7(16):e1800361. Epub 2018 Jun 27.

Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.

Bioactive glass (BG) can repair bone defects, however, it is not clear whether BG has the ability for bone augmentation without making any bone defect. Unlike the intramembranous osteogenesis in bone defect repair, the extramembranous osteogenesis occurs outside the cortical bone and the osteoprogenitor cells show the reversed migration. Herein, nanoscale bioactive glass scaffolds (BGSs) are fabricated, and their role and immunomodulation-related mechanism in the extramembranous osteogenesis are investigated. Read More

Ann Pathol 2018 Apr 23;38(2):92-102. Epub 2018 Mar 23.

Service d'anatomie pathologique et neuropathologie, department of pathology, CHU de Timone, Assistance publique-Hôpitaux de Paris (AP-HP), BMT-Timone 2, 2(e) étage, 264, rue Saint-Pierre, 13000 Marseille, France.

The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Read More

Bone 2018 03 4;108:145-155. Epub 2018 Jan 4.

Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, USA; Department of Orthopaedic Surgery, New York University Langone Health, NYU Langone Orthopedic Hospital, NY, USA; Department of Veterans Affairs New York Harbor Healthcare System, New York, NY, USA. Electronic address:

Mechanical loading is an important aspect of post-surgical fracture care. The timing of load application relative to the injury event may differentially regulate repair depending on the stage of healing. Here, we used a novel mechanobiological model of cortical defect repair that offers several advantages including its technical simplicity and spatially confined repair program, making effects of both physical and biological interventions more easily assessed. Read More

Int J Biomater 2017 28;2017:7571523. Epub 2017 Sep 28.

Department of Orthopaedics and Traumatology, Airlangga University, Dr. Soetomo General Hospital, Surabaya, Indonesia.

Autogenous bone graft is gold standard in treating bone defects, but it might have difficulty in corporation and rejection reaction. This study is to compare the effectiveness among freeze-dried xenograft, freeze-dried allograft, hydroxyapatite xenograft, and demineralized bone matrix xenograft as bone graft to fill bone defect in femoral diaphysis of white rabbit. Thirty male New Zealand white rabbits were distributed into five groups. Read More

Georgian Med News 2017 Jan(262):4-14

Kharkov Medical Academy of Postgraduate Education, Department of Radiology and Paediatric Radiology, Department of Radiologic Diagnostics, Ukraine.

Metaphyseal cortical defect (metaphyseal fibrous defect, cortical fibrous defect) of the long bones is a quite common variant of the bone structure's pathologic changes. The cortical defects and similar to their tumor-like processes (non-ossifying fibroma, benign fibrous histiocytoma etc.) are characterized by particular qualities of the clinical symptoms and radiologic signs. Read More

Indian J Orthop 2016 Jul-Aug;50(4):366-73

Department of Orthopaedics, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Ununited femoral neck fracture is seen commonly in developing countries due to delayed presentation or failure of primary internal fixation. Such fractures, commonly present with partial or total absorption of femoral neck, osteonecrosis of femoral head in 8-30% cases with upward migration of trochanter posing problem for osteosynthesis, especially in younger individuals. Several techniques for treatment of such conditions are described like osteotomies or nonvascularied cortical or cancellous bone grafting provided varying degrees of success in terms of fracture union but unsatisfactory long term results occurred due to varying incidence of avascular necrosis (AVN) of femoral head. Read More

Biofabrication 2016 07 26;8(3):035007. Epub 2016 Jul 26.

LifeNet Health Institute of Regenerative Medicine, Virginia Beach, VA, USA.

Introduction: Bone repair frequently requires time-consuming implant construction, particularly when using un-formed implants with poor handling properties. We therefore developed osteoinductive, micro-fibrous surface patterned demineralized bone matrix (DBM) fibers for engineering both defect-matched and general three-dimensional implants.

Methods And Results: Implant molds were filled with demineralized human cortical bone fibers there were compressed and lyophilized, forming mechanically strong shaped DBM scaffolds. Read More

Orthopedics 2016 Nov 26;39(6):e1197-e1200. Epub 2016 Jul 26.

Small nonossifying fibromas (ie, fibrocortical defects) are incidental findings commonly seen on radiographs of young patients evaluated for extremity pain or sport-related trauma. Although pathological fractures have been reported in larger lesions, the subcentimeter, intracortical defects are not generally thought to predispose to pathological fractures. The authors report on 2 young athletes who presented with knee pain after initiating conditioning exercise programs (cross-training). Read More

Oncol Lett 2016 May 22;11(5):3185-3188. Epub 2016 Mar 22.

Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.

Intraosseous schwannoma is a rare benign bone tumor that originates from Schwann cells of the nerve sheath. The majority of intraosseous schwannomas arise in the mandible and sacrum, but an intraosseous schwannoma involving the ulna is described in the present case report. Radiologically, the current case presented as a well-defined lytic lesion, with a pathological fracture and no intralesional calcification, in the proximal metaphysis of the left ulna. Read More

Childs Nerv Syst 2016 Jun 19;32(6):1141-4. Epub 2015 Nov 19.

Department of Neurosurgery, University of Fukui, 23-3, Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

Purpose: A cephalocele is a congenital anomaly involving the herniation of intracranial tissue from a skull defect. The sac containing the central nervous system (CNS) with the ventricle system is called the encephalocystocele. An atretic cephalocele is thought to be an abortive form of cephalocele, and the essential nature is still controversial. Read More

Nanotechnology 2015 Oct 16;26(40):405101. Epub 2015 Sep 16.

Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetham University, Kochi, Kerala 682041, India.

Porous nanohydroxyapatite (nanoHA) is a promising bone substitute, but it is brittle, which limits its utility for load bearing applications. To address this issue, herein, biodegradable electrospun microfibrous sheets of poly(L-lactic acid)-(PLLA)-polyvinyl alcohol (PVA) were incorporated into a gelatin-nanoHA matrix which was investigated for its mechanical properties, the physical integration of the fibers with the matrix, cell infiltration, osteogenic differentiation and bone regeneration. The inclusion of sacrificial fibers like PVA along with PLLA and leaching resulted in improved cellular infiltration towards the center of the scaffold. Read More

J Orthop Surg Res 2015 Aug 14;10:123. Epub 2015 Aug 14.

Department of Orthopaedics, Istanbul Training and Research Hospital, Istanbul, Turkey.

Background: We evaluated the mid-term results of previously cemented hip arthroplasties revised with uncemented modular femoral components.

Methods: The study included 40 patients (36 females (90 %) and 4 males (10 %), mean age 67.6 years, range 39-87 years) who underwent revision of a previously cemented hip prosthesis with an uncemented modular femoral stem between 2005 and 2009. Read More

Rev Esp Med Nucl Imagen Mol 2015 May-Jun;34(3):181-4. Epub 2015 Jan 5.

Servei de Medicina Nuclear, Hospital Universitari de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Non-ossifying fibromas (NOF) are a benign entity of the developing bone, relatively common in children and young adults. Their location is most frequently metaphyseal. They are usually asymptomatic (unless associated to a fracture) and have a self-limited behavior, with spontaneous regression through a sclerotic consolidation. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jan 28;119(1):92-100. Epub 2014 Sep 28.

Associate Professor, Division of Oral Pathology, Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Objective: To investigate central lesions of the jaws dominated by foamy macrophages (foam cells), which are interpreted to be "central xanthomas of the jaws" and to differentiate this condition from reported cases of jaw nonossifying fibroma/fibrous cortical defect and benign fibrous histiocytoma of bone.

Study Design: The study is a literature review and a retrospective analysis of clinical, radiographic, microscopic, and immunohistochemical features of five new cases of this condition.

Results: The lesion has a predilection for the mandible in adults of variable ages, with the potential to become very large and destructive; however, it has a very low recurrence rate, if any, following surgical curettage. Read More

Eur Cell Mater 2014 Oct 6;28:209-21; discussion 221-2. Epub 2014 Oct 6.

Bone Engineering Labs, Research Institute-McGill University Health Centre, Surgical Research, C9.133, Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, H3G 1A4,

KitW-sh mice carry an inactivating mutation in the gene encoding the receptor for stem cell factor, which is expressed at high levels on the surface of haematopoietic precursor cells. The mutation results in mast cell deficiency, a variety of defects in innate immunity and poorly defined abnormalities in bone. The present study was designed to characterise healing of a cortical window defect in skeletally mature KitW-sh mice using high-resolution micro computed tomographic imaging and histological analyses. Read More

Clin Oral Implants Res 2015 Oct 15;26(10):1150-7. Epub 2014 Sep 15.

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.

Objectives: This study aimed to evaluate the biologic and structural phenotypes of the bone regenerated via the sandwich bone augmentation (SBA) technique, on buccal implant dehiscence defects.

Material And Methods: Twenty-six patients with one buccal implant dehiscence defect each were randomly assigned to two groups. Both groups received a standardized amount of mineralized cancellous and cortical allogenic bone graft. Read More

Oper Orthop Traumatol 2014 Apr 2;26(2):162-70. Epub 2014 Apr 2.

Chirurgische Klinik I, Klinik für Unfall- und Orthopädische Chirurgie, Krankenhaus Düren gem. GmbH, Roonstr. 30, 52351, Düren, Deutschland,

Objective: Biological augmentation and stabilization of high-grade bone defects with structural allografts from donor femur halfs.

Indications: Severe bone defects with aseptic loosening of hip prosthesis, periprosthetic femoral fracture or non-union, possibly even in cases of a healed infection.

Contraindications: Local or systemic infection. Read More

Genet Couns 2013 ;24(4):373-9

Department of Orthopedic Surgery, University Hospitals Leuven, Pellenberg, Belgium.

Focal fibrocartilaginous dysplasia (FFCD) is an uncommon, benign bone lesion that causes angular deformities of the long bones in young children. Most deformities were seen around the knee. Diagnostic criteria are based on clinical and radiological signs: unilateral angular deformity in a long bone of a young child, associated with on X-ray a typical lucent bony defect with surrounding sclerosis at the concavity of the deformity with a cortical defect. Read More

J Biomed Mater Res A 2014 Aug 30;102(8):2521-32. Epub 2013 Aug 30.

Department of Bioengineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, 16802.

Natural bone apatite crystals, which mediate the development and regulate the load-bearing function of bone, have recently been associated with strongly bound citrate molecules. However, such understanding has not been translated into bone biomaterial design and osteoblast cell culture. In this work, we have developed a new class of biodegradable, mechanically strong, and biocompatible citrate-based polymer blends (CBPBs), which offer enhanced hydroxyapatite binding to produce more biomimetic composites (CBPBHAs) for orthopedic applications. Read More

Srp Arh Celok Lek 2012 Sep-Oct;140(9-10):658-61

Introduction: In forensic autopsy, pathologists are not particularly interested in the anatomical morphological variations of the skull bones, especially if those variations are not very frequent. Foramina parietalia permagna are developmental benign anomalies resulting from large ossification defects of the parietal bone.

Case Outline: Herein was presented a case of 80-year-old female, whose autopsy revealed congenital defect of parietal bones--enlarged parietal foramina. Read More

Case Rep Orthop 2012 26;2012:439836. Epub 2012 Mar 26.

Rheumatology Department, Mohammed VI Medical Center, Marrakesh, Morocco.

Penetrating wounds of the foot are not uncommon. Many are caused by thorns or by fragments of wood that are retained in the foot, creating a foreign-body granuloma. The differential diagnosis for bony reaction to an unrecognised organic foreign body includes osteoid osteoma, chronic and acute osteomyelitis, tuberculosis granuloma, bone cyst, aneurysmal bone cyst, cortical fibrous defect, and neoplasm. Read More

Pol J Radiol 2011 Oct;76(4):32-9

1 Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.

Background: To assess and describe the variability of radiological presentations of fibrous cortical defects and non-ossifying fibromas in children and young adults.

Material/methods: Medical records of 28 patients (15 males, 13 females, mean age of 17 years) with a radiological diagnosis of cortical fibrous defect or non-ossifying fibroma were reviewed retrospectively. The presentation of the lesion, its location and morphology according to Ritschl's classification, as well as the number and types of imaging studies performed in the study group were assessed. Read More

J Bone Miner Res 2012 Jun;27(6):1275-88

Julius Wolff Institute and Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Institutsgebäude Süd/Südstraße 2, Augustenburger Platz 1, Berlin, Germany.

Critical-sized bone defect regeneration is a remaining clinical concern. Numerous scaffold-based strategies are currently being investigated to enable in vivo bone defect healing. However, a deeper understanding of how a scaffold influences the tissue formation process and how this compares to endogenous bone formation or to regular fracture healing is missing. Read More

World J Surg Oncol 2011 Dec 9;9:163. Epub 2011 Dec 9.

Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.

We report a case of primary clear cell sarcoma occurring in the humerus. A 20 year old girl was referred to our hospital two years ago with painless swelling of the soft tissue surrounding the proximal right humerus. The conventional radiographic image showed an ill-defined, aggressive, osteolytic lesion associated with a partial cortical defect of the proximal right humerus. Read More

Injury 2011 Aug 14;42(8):765-71. Epub 2010 Dec 14.

Department of Trauma, Hand & Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany.

Purpose: Due to the great availability of specific antibodies, gene-targeted animals and knockout strains, mouse models came into the focus of musculoskeletal research. Herein, we introduce a calvarian defect model in mice that allows the repetitive analysis of blood vessel formation during bone repair by intravital microscopy.

Methods: The right parietal calvaria of 20 adult CD-1 mice were exposed by skin excision. Read More

Arthroscopy 2011 Jan 16;27(1):60-4. Epub 2010 Oct 16.

Plano Orthopedic Sports Medicine and Spine Center, Plano, Texas, USA.

Purpose: To evaluate the radiographic response of a synthetic multiphase implant at various intervals after implantation and assess the nature of bone ingrowth into the implant location.

Methods: Patients undergoing autologous osteochondral transplantation for full-thickness condylar defects with the donor sites filled by use of a synthetic implant were evaluated by computed tomography (CT) scan for the density at both donor and recipient sites. Hounsfield unit (HU) readings were obtained at the synthetic implant, transplanted autograft plug, soft-tissue, cancellous bone, and cortical bone sites. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Oct 6;110(4):504-8. Epub 2010 Aug 6.

Division of Oral and Maxillofacial Pathology, Department of Oral Health and Diagnostic Sciences, School of Dentistry, The Medical College of Georgia, Augusta, GA 30912, USA.

Fibrous cortical defect, also known as metaphyseal fibrous defect and nonossifying fibroma, among other terms, is a benign, non-neoplastic proliferative process that is relatively common in the long bones of skeletally immature adolescents. Although the lesion is thought to be a developmental abnormality or defect, the exact etiopathogenesis is largely unknown. The lesion has a limited growth potential and good treatment outcome. Read More

Hand Surg 2010 ;15(2):127-9

Plastic and Hand Surgery Department, University Freiburg Medical Centre, 79106 Freiburg, Germany.

Benign fibrous histocytoma of bones is a very rare tumour and only a few cases have been reported. We report a case of 40-year-old patient with no significant previous medical history who presented with a painful lesion in his right wrist joint. Incision biopsy was done and there was a histological picture similar to a metaphyseal fibrous defect (non-ossifying fibroma). Read More

Calcif Tissue Int 2010 Jul 22;87(1):90-8. Epub 2010 May 22.

Research Department, Center for Military Medicine, Töölönkatu 44-48 D 65, 00250, Helsinki, Finland.

We performed qualitative and histoquantitative investigations of tissue restoration after implanting polyglycolide (PGA), polydioxanone (PDS), polylevolactide (PLLA), and stainless steel pins in the intramedullary canal of rabbit femurs. The effect of bioabsorbable devices on healing of a cortical bone defect was also assessed. The cortical bone defect was created in the right femur of 80 rabbits. Read More

J Cancer Res Ther 2010 Jan-Mar;6(1):92-4

Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai-400 012, India.

With increasing use of 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in the current oncological practice, there is a growing body of evidence of false positive scans due to various benign conditions. In this communication we present intensely avid 18 F-FDG uptake in fibrous dysplasia of right tibia in a 12-year-old child suffering from embryonal rhabdomyosarcoma (ERMS) that could have been easily mistaken to be a metastatic focus if not carefully correlated. The patient was a case of ERMS (presenting with left cervical mass with intrathoracic extension) who was treated successfully with chemotherapy and was referred for FDG-PET to evaluate the disease status. Read More

Clin Radiol 2010 May 23;65(5):382-6. Epub 2010 Mar 23.

Department of Radiology, Royal Orthopaedic Hospital, Birmingham, UK.

Aim: To investigate the association of a fatigue-type stress fracture and a fibrous cortical defect/non-ossifying fibroma (FCD/NOF) of the lower limb long bones in skeletally immature patients.

Materials And Methods: The patient database of a specialist orthopaedic oncology centre was searched to determine the number of skeletally immature patients (Read More

Foot (Edinb) 2009 Mar 30;19(1):58-61. Epub 2009 Jan 30.

Musculoskeletal Oncology Unit, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK.

Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours. It is a slow growing low grade malignant tumour which is often clinically, radiologically and histologically mistaken for many other tumours like Ewing's sarcoma, synovial sarcoma, fibrosarcoma, metastatic carcinoma, fibrous cortical defect and osteofibrous dysplasia. Adamantinoma commonly occurs in the tibia. Read More

Homo 2010 Apr 1;61(2):130-49. Epub 2010 Mar 1.

Laboratory for Anthropology, Department of Anatomy, School of Medicine, University of Belgrade, 4/2 Dr Subotica, 11000 Belgrade, Serbia.

Although pattern of health in adults has been frequently assessed in past human populations, health status of adolescents as a distinct life stage has usually been overlooked. Inconsistency in number and meaning of recognised age categories in anthropological literature, as well as chronological age ranges used to define them, further complicate the interpretation of adolescent health. In this study, we analysed signs of pathological conditions on skeletal remains of 81 adolescents from a medieval site of Stara Torina (northern Serbia). Read More

Chir Organi Mov 2009 May 29;93(1):1-7. Epub 2009 Apr 29.

Orthopaedic Research Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA.

Non-ossifying fibroma of bone (NOF) is a common entity, more frequently found in male children and consisting of a solitary eccentric, lytic expanded lesion in the metaphysis of a long bone. The disorder is benign and most often asymptomatic but may result in a fracture requiring therapy. Of some importance is to distinguish NOF from another very similar but smaller lesion, fibrous cortical defect, which is almost always asymptomatic and eccentrically located. Read More

Tissue Eng Part A 2009 Oct;15(10):3061-9

Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.

The bone bonding potential of surface-phosphorylated poly (2-hydroxyethyl methacrylate-co-methyl methacrylate) [poly (HEMA-co-MMA)] has been investigated and compared with commercially available poly (methyl methacrylate) bone cement (CMW1 radiopaque, Depuy; Johnson & Johnson, Blackpool, Lancashire, England, United Kingdom) as control. Poly (HEMA-co-MMA) is synthesized by free radical-initiated copolymerization and surface functionalized by phosphorylation. The X-ray photoelectron spectroscopy confirms the presence of surface-bound phosphate groups on poly (HEMA-co-MMA). Read More

Hand Surg 2008 ;13(2):99-102

Orthopedics and Traumatology Department, Faculty of Medicine, Ankara University, Samanpazari, Ankara, Turkey.

Benign fibrous histiocytoma (BFH) of the bone is a rare benign lesion characterised by the presence of fibroblasts and histiocytes. Fibrohistocytic lesions involving bone with identical histological appearances are common during childhood such as fibrous cortical defect. However, BFH is very rare and can only be differentially diagnosed with its presentation, localisation and radiologic features. Read More

Biomaterials 2008 Dec 14;29(35):4616-29. Epub 2008 Sep 14.

Department of Sports Medicine, Peking University Third Hospital, Beijing 100083, PR China.

We reported a technique for articular cartilage repair, consisting of microfracture, a biomaterial scaffold of perforated decalcified cortical bone matrix (DCBM) and adenovirus-bone morphogenetic protein-4 (Ad-BMP4) gene therapy. In the present study, we evaluated its effects on the quality and quantity for induction of articular cartilage regeneration. Full-thickness defects were created in the articular cartilage of the trochlear groove of rabbits. Read More

Eur J Nucl Med Mol Imaging 2008 Nov 20;35(11):2000-8. Epub 2008 Aug 20.

Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Raemistr. 100, 8091, Zurich, Switzerland.

Objective: To evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18 fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT).

Materials And Methods: In 50 consecutive patients (21 women, 29 men, mean age 36. Read More

J Huazhong Univ Sci Technolog Med Sci 2008 Aug 15;28(4):426-30. Epub 2008 Aug 15.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

In this study, the bioactivity of a novel BMP2-derived oligopeptide P24 was investigated by using the model of rabbit femoral defect after loaded in the biodegradable poly (lactic acid / glycolic acid / asparagic acid-co-polyethylene glycol) (PLGA-[ASP-PEG]). A 1.5-cm unilateral segmental bone defect was created in the left femoral diaphysis in each of the 30 new zealand white rabbits. Read More

Med Pregl 2007 Nov-Dec;60(11-12):649-51

Klinicki centar Vojvodine, Klinika za maksilofacijalnu hirurgiju, Medicinski fakultet Novi Sad.

Introduction: Chondromas are uncommon benign tumors of cartilaginous origin. Although chonodroma of the jaw is extremely rare, the commonly involved are the anterior portion of the maxilla, condyle and coronoid process. A chondroma is a painless, slow growing tumor causing destruction and exfoliation of teeth. Read More

Chir Organi Mov 2008 Feb 3;91(2):65-70. Epub 2008 Mar 3.

Section B of Shoulder and Elbow Surgery, Istituti Ortopedici Rizzoli, Via Pupilli 1, 40136 Bologna, Italy.

We reviewed our experience in the surgical treatment of 12 cases of proximal ulna nonunion. The primary injuries were 2 fracture-dislocations of the olecranon, 6 Monteggia lesions and 3 isolated fractures of the proximal ulna. According to the type of primary injury and its anatomical site, the nonunions were classified into 2 groups, considering that the nonunions nearest to the humerus-ulna joint present a more disabling clinical profile and are more difficult to treat: group A (6 patients - nonunion within 5 cm from the olecranon tip of the olecranon) and group B (6 patients - nonunion between 5 and 10 cm from the olecranon tip of the olecranon). Read More

Orthopedics 2008 Jan;31(1):95

Department of Orthopedics, Kocaeli University School of Medicine, Izmit, Turkey.

Biomaterials 2008 Mar;29(8):984-93

Department of Materials Science and Engineering, National Cheng-Kung University, 70101 Tainan, Taiwan, ROC.

One primary focus of the present study was to clarify the crucial resorption-location relationship of a recently developed single-phase TTCP-derived calcium phosphate cement (CPC) implanted in rabbit femur in a systematic and quantitative way. Gross examination of retrieved CPC/bone composite samples indicated that the CPC implant did not evoke inflammatory response, necrosis or fibrous encapsulation in surrounding bony tissues. Histological examination revealed excellent CPC-host bone bonding. Read More

Indian J Otolaryngol Head Neck Surg 2007 Jun 14;59(2):157-9. Epub 2007 Sep 14.

IGMC Shimla, 171 001 Himachal Pradesh, India.

Fibrous dysplasia represents a disturbance of normal bone development specifically a defect in osteoblastic differentiation and maturation that originates in the mesenchymal precursor of the bone. In fibrous dysplasia, the lesion expands, which leads to a distortion and weakening of bone. Although the lesion is not encapsulated, it tends to remain enclosed within a shell of cortical bone. Read More

Ann Plast Surg 2007 May;58(5):561-5

Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

Currently available options for the repair of bony defects have substantial limitations. Much work has looked to the possibility of engineering bone using stem cells. These tissue-engineering efforts have focused on calvarial defect models, which have the advantages of minimal load-bearing and a large surface area. Read More

J Biomater Appl 2007 Nov 25;22(3):223-39. Epub 2007 Jan 25.

Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University, Beijing 100084, China.

In scaffold based bone tissue engineering, both the pore size and the mechanical properties of the scaffold are of great importance. However, an increase in pore size is generally accompanied by a decrease in mechanical properties. In order to achieve both suitable mechanical properties and porosity, a multilayer scaffold is designed to mimic the structure of cancellous bone and cortical bone. Read More

Int J Biochem Cell Biol 2007 10;39(3):469-77. Epub 2006 Oct 10.

School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia.

Duchenne muscular dystrophy is a lethal X-linked muscle disease resulting from a defect in the muscle membrane protein dystrophin. The absence of dystrophin leads to muscle membrane fragility, muscle death (necrosis) and eventual replacement of skeletal muscle by fat and fibrous connective tissue. Extensive muscle wasting and respiratory failure results in premature death often by the early 20s. Read More

J Bone Joint Surg Br 2006 Jul;88(7):960-6

Department of Veterinary Clinical Sciences, University of Minnesota, 1352 Boyd Avenue, St. Paul, Minnesota 55108, USA.

Critical size defects in ovine tibiae, stabilised with intramedullary interlocking nails, were used to assess whether the addition of carboxymethylcellulose to the standard osteogenic protein-1 (OP-1/BMP-7) implant would affect the implant's efficacy for bone regeneration. The biomaterial carriers were a 'putty' carrier of carboxymethylcellulose and bovine-derived type-I collagen (OPP) or the standard with collagen alone (OPC). These two treatments were also compared to "ungrafted" negative controls. Read More

J Craniofac Surg 2006 May;17(3):420-5

Division of Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Traditional formulations of bone wax are composed largely of beeswax and are well known to interfere with bone healing and cause inflammatory reactions. Ostene, a newly available bone hemostasis agent made of water-soluble alkylene oxide copolymers, was evaluated. The soft tissue response to Ostene was compared with bone wax and a polyethylene control after implantation into the paravertebral muscles of three rabbits. Read More