Colloids Surf B Biointerfaces 2022 Aug 18;216:112580. Epub 2022 May 18.
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India; Centre for Environmental Sciences and Engineering, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India; Centre for Nanosciences, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India; The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India. Electronic address:
Tissue plasminogen activators induce enzymatic activation of plasminogen to plasmin that cleaves fibrin strands in blood clots. In the present study, extracellular vesicles such as exosomes from fibrosarcoma cell line HT1080 were utilized as clot-busting agents. These exosomes were being used for clot lysis of whole blood which showed 28% lysis within 10 h, which was comparable to that of the streptokinase (commercial plasmin activator) with no significant difference. Read More