17,151 results match your criteria Fibrosarcoma


High-affinity T cell receptors for adoptive cell transfer.

J Clin Invest 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, Medicine and Oncology, and.

Adoptive cell transfer (ACT) of engineered T cell receptors (TCRs) for cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhancement techniques that overcome limitations imposed by central and peripheral tolerance on TCR affinity. In the current issue of the JCI, Poncette et al. used mice with human TCRαβ and HLA gene loci to discover CD4+ TCRs of optimal affinity for cancer testis antigen (CTA) NY-ESO-1. Read More

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December 2018

Novel NTRK3 Fusions in Fibrosarcomas of Adults.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Rare Cancer Center.

NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More

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December 2018
7 Reads

1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] Inhibits MMP-9 Expression by Regulating NF-κB and MAPKs Signaling Pathways in HT1080 Human Fibrosarcoma Cells.

Evid Based Complement Alternat Med 2018 5;2018:5639486. Epub 2018 Nov 5.

College of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China.

Hippocampus is a traditional medicine in China, which can be used for treating tumors, aging, fatigue, thrombosis, inflammation, hypertension, prostatic hyperplasia, and other diseases. 1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] from seahorse (a Bleeler) has been shown to suppress proinflammatory responses. In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner. Read More

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November 2018

Metformin induces CD11b+ cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and antitumor effects.

Int Immunol 2018 Dec 2. Epub 2018 Dec 2.

Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell-mediated antitumor immunity. Regulation of these cell types is a primary goal for achieving efficient cancer immunotherapy. We found that metformin (Met) induces CD11b+ cell-mediated growth inhibition of a K7M2neo osteosarcoma independent of T cells, as growth inhibition of K7M2neo was still observed in wild type (WT) mice depleted of T cells by antibodies and in SCID; this contrasted with the effect of Met on Meth-A fibrosarcoma, which was entirely T cell-dependent. Read More

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December 2018
2 Reads

On the Relationship between Dynamic Contrast-Enhanced Ultrasound Parameters and the Underlying Vascular Architecture Extracted from Acoustic Angiography.

Ultrasound Med Biol 2018 Nov 30. Epub 2018 Nov 30.

Department of Electrical Engineering, Technical University of Eindhoven, Eindhoven, The Netherlands.

Dynamic contrast-enhanced ultrasound (DCE-US) has been proposed as a powerful tool for cancer diagnosis by estimation of perfusion and dispersion parameters reflecting angiogenic vascular changes. This work was aimed at identifying which vascular features are reflected by the estimated perfusion and dispersion parameters through comparison with acoustic angiography (AA). AA is a high-resolution technique that allows quantification of vascular morphology. Read More

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November 2018

Low-grade fibromyxoid sarcoma of the extremities: a clinicopathologic study of 24 cases and review of the literature.

Pol J Pathol 2018 ;69(3):219-225

Low-grade fibromyxoid sarcoma (LGFMS) and hybrid sclerosing epithelioid fibrosarcoma (SEF)/LGFMS have a low potential for recurrence (10%) and metastasis (5%) but they are notorious for late occurring metastases. The aim of this study was to evaluate the outcome of LGFMS and review similar cases reported in the literature. We retrospectively evaluated 24 LGFMS operated at a single Institution. Read More

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January 2018
2 Reads

[Leptomeningeal metastasis of myxofibrosarcoma: a case report].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):877-878

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China.

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November 2018
1 Read

Descending thoracic aortic aneurysm revealing metastasis of a soft tissue fibrosarcoma: a case report and review of the literature.

Clin Sarcoma Res 2018 26;8:22. Epub 2018 Oct 26.

1Department of Interventional Radiology, Centre Léon Bérard, 28 rue Laennec, 69008 Lyon, France.

Background: Review of the first documented case of aortic wall metastasis from a limb sarcoma.

Case Presentation: In a 56-year-old woman with a diagnosis of a high-grade limb fibrosarcoma, an aortic metastasis was revealed by a fast growing aneurysm of the descending thoracic aorta. This was managed with an endoprosthesis. Read More

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October 2018
1 Read

Long Pentraxin 3-Mediated Fibroblast Growth Factor Trapping Impairs Fibrosarcoma Growth.

Front Oncol 2018 1;8:472. Epub 2018 Nov 1.

Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy.

Fibrosarcomas are soft tissue mesenchymal tumors originating from transformed fibroblasts. Fibroblast growth factor-2 (FGF2) and its tyrosine-kinase receptors (FGFRs) play pivotal roles in fibrosarcoma onset and progression, FGF2 being actively produced by fibroblasts in all stages along their malignant transformation to the fibrosarcoma stage. The soluble pattern recognition receptor long pentraxin-3 (PTX3) is an extrinsic oncosuppressor whose expression is reduced in different tumor types, including soft tissue sarcomas, via hypermethylation of its gene promoter. Read More

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November 2018
2 Reads

A Familial Case of Multicentric Carpotarsal Osteolysis Syndrome and Treatment Outcome.

J Pediatr Genet 2018 Dec 16;7(4):174-179. Epub 2018 Jun 16.

Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Multicentric carpotarsal osteolysis syndrome (MCTO) is a rare skeletal disorder caused by heterozygous mutations in the gene (v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B). This is an autosomal dominant condition with a high frequency of sporadic cases. MCTO is characterized by osteolysis of the carpal, metacarpal, and tarsal bones beginning in early childhood with musculoskeletal rheumatologic symptoms such as pain and disability. Read More

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December 2018
4 Reads

Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

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November 2018
2 Reads

Oxygen-guided radiation therapy.

Int J Radiat Oncol Biol Phys 2018 Nov 8. Epub 2018 Nov 8.

NIH Center for EPR Imaging In Vivo Physiology; University of Chicago, USA; Department of Radiation and Cellular Oncology, University of Chicago, USA. Electronic address:

Background: It has been known for over a hundred years that tumor hypoxia, a near-universal characteristic of solid tumors, decreases the curative effectiveness of radiation therapy. However, to date, there are no reports that demonstrate an improvement in radiation effectiveness in a mammalian tumor based on tumor hypoxia localization and local hypoxia treatment.

Methods: For radiation targeting of hypoxic subregions in a mouse fibrosarcoma, we used oxygen images obtained using electron paramagnetic resonance (EPR) pO imaging combined with 3D-printed radiation blocks. Read More

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November 2018
4 Reads

Inhibition of perilipin 2 expression reduces pro-inflammatory gene expression and increases lipid droplet size.

Food Funct 2018 Dec;9(12):6245-6256

University of California, Davis, School of Medicine, Department of Internal Medicine, Division of Cardiovascular Medicine, GBSF 5404, 451 Health Sciences Dr. Davis, CA 95616, USA.

Our lab previously demonstrated that triglyceride-rich lipoprotein (TGRL) lipolysis products induce lipid droplet formation and pro-inflammatory gene expression in monocytes. We hypothesized that the inhibition of perilipin 2 expression in THP-1 monocytes would reduce lipid droplet formation and suppress pro-inflammatory gene expression induced by TGRL lipolysis products. In the current study, we use microarray analysis to identify gene expression altered by TGRL lipolysis products in THP-1 monocytes. Read More

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December 2018
2 Reads

Status of programmed death-ligand 1 expression in sarcomas.

J Transl Med 2018 Nov 6;16(1):303. Epub 2018 Nov 6.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea.

Background: Sarcomas are challenging to study because of their rarity and histomorphological complexity. PD1 and PD-L1 inhibitors showed a promising anti-tumor effect in solid tumors, where a relationship between PD-L1 expression and the objective response has been evidenced.

Methods: In this study, we examined PD-L1 expression in 16 bone and soft tissue sarcoma cell lines of 11 different subtypes by means of western blot, flow cytometry and immunocytochemistry, and in 230 FFPE patient-derived tumor tissues by means of immunohistochemistry using three different antibody clones. Read More

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November 2018
5 Reads

Synthesis and antiproliferative activities of doxorubicin thiol conjugates and doxorubicin-SS-cyclic peptide.

Eur J Med Chem 2019 Jan 23;161:594-606. Epub 2018 Oct 23.

Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, 92618, United States. Electronic address:

Myocardial toxicity and drug resistance caused by drug efflux are major limitations of doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to develop conjugates with an improved biological profile, such as antiproliferative activity and higher cellular retention. Thus, Dox thiol conjugates, Dox thiol (Dox-SH), thiol-reactive Dox-SS-pyridine (SS = disulfide), and a Dox-SS-cell-penetrating cyclic peptide, Dox-SS-[C(WR)K], were synthesized. Read More

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January 2019
7 Reads
3.450 Impact Factor

Different cytotoxic and apoptotic responses of MCF-7 and HT1080 cells to MnO nanoparticles are based on similar mode of action.

Toxicology 2018 Nov 3;411:71-80. Epub 2018 Nov 3.

King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Saudi Arabia. Electronic address:

Manganese (IV) oxide nanoparticles (MnO NPs) are increasingly used in numerous applications. Multiple applications of MnO NPs, however, increase the human exposure and thus potential risk related to their toxicity. There is little information regarding the toxicity mechanisms of MnO NPs in human cells. Read More

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November 2018
6 Reads

Structural snapshots of RAF kinase interactions.

Biochem Soc Trans 2018 Oct 31. Epub 2018 Oct 31.

Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany

RAF (rapidly accelerated fibrosarcoma) Ser/Thr kinases (ARAF, BRAF, and CRAF) link the RAS (rat sarcoma) protein family with the MAPK (mitogen-activated protein kinase) pathway and control cell growth, differentiation, development, aging, and tumorigenesis. Their activity is specifically modulated by protein-protein interactions, post-translational modifications, and conformational changes in specific spatiotemporal patterns via various upstream regulators, including the kinases, phosphatase, GTPases, and scaffold and modulator proteins. Dephosphorylation of Ser-259 (CRAF numbering) and dissociation of 14-3-3 release the RAF regulatory domains RAS-binding domain and cysteine-rich domain for interaction with RAS-GTP and membrane lipids. Read More

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October 2018
1 Read

Codelivery of a cytotoxin and photosensitiser via a liposomal nanocarrier: a novel strategy for light-triggered cytosolic release.

Nanoscale 2018 Nov;10(43):20366-20376

Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PE, UK.

Endosomal entrapment is a key issue for the intracellular delivery of many nano-sized biotherapeutics to their cytosolic or nuclear targets. Photochemical internalisation (PCI) is a novel light-based solution that can be used to trigger the endosomal escape of a range of bioactive agents into the cytosol leading to improved efficacy in pre-clinical and clinical studies. PCI typically depends upon the endolysosomal colocalisation of the bioactive agent with a suitable photosensitiser that is administered separately. Read More

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November 2018

Characterizing the DNA damage response in fibrosarcoma stem cells by in-situ cell tracking.

Int J Radiat Biol 2018 Oct 29:1-8. Epub 2018 Oct 29.

a Sino-French Institute of Nuclear Engineering and Technology , Sun Yat-sen University , Zhuhai , PR China.

Purpose: Radiotherapy works by generating large amounts of DNA double-strand breaks (DSBs). Cancer stem-like cells (CSCs) are the principal cause of tumor radioresistance. Therefore, investigating the dynamics and mechanisms of DNA damage response (DDR) in CSCs is of great importance. Read More

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October 2018
6 Reads

Immunomodulatory Effects of Blood Transfusion on Tumor Size, Metastasis, and Survival in Experimental Fibrosarcoma.

Indian J Hematol Blood Transfus 2018 Oct 24;34(4):697-702. Epub 2018 May 24.

2Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

In spite of efforts, blood transfusion is still accompanied with adverse effects such as transfusion-related immunomodulation (TRIM). The current study aimed to evaluate the effects of allogeneic, syngeneic, fresh and storage blood transfusion on the growth and metastasis of tumors and survival in fibrosarcoma bearing BALB/c mice. Twenty-five BALB/c mice were grouped into five groups of equal size. Read More

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October 2018
7 Reads
0.234 Impact Factor

Tumor suppressive activity of PIWI-interacting RNA in human fibrosarcoma mediated through repression of RRM2.

Mol Carcinog 2018 Oct 26. Epub 2018 Oct 26.

RNAi and Functional Genomics Lab, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.

P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a promising class of small regulatory RNAs, earlier believed to control transposable elements (TEs) activity in germlines are now reported in somatic and cancer cells. The aberrant expression of piRNAs has been documented in various cancers wherein they modulate tumorigenesis either as oncogenes or tumor suppressors by curbing target gene expression. However, there is no report yet on the association of piRNAs in fibrosarcoma, an early metastatic lethal tumor. Read More

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October 2018
4 Reads

New generation CPPs show distinct selectivity for cancer and noncancer cells.

J Cell Biochem 2018 Oct 25. Epub 2018 Oct 25.

Department of Experimental Radiology, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany.

In the last three decades, many new cell-penetrating peptides (CPPs) were developed that exhibited enhanced cell selectivity. Thus, we aimed to validate the tumor cell selectivity of peptides from this new generation, namely fragments mini-crotamine and mini-maurocalcine. Both of these peptides are derived from venoms. Read More

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October 2018
3 Reads

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Cell Rep 2018 Oct;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to generate a Cdkn1a mouse, which harbors an additional Cdkn1a allele within its natural genomic context. Read More

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October 2018
6 Reads

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.

Cell Rep 2018 Oct;25(4):1018-1026.e4

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92037, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG) accumulation, the metabolic consequences of these mutations may also provide therapeutic opportunities. Here we apply flux-based approaches to genetically engineered cell lines with an endogenous IDH1 mutation to examine the metabolic impacts of increased D2HG production and altered IDH flux as a function of IDH1 mutation or expression. Read More

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October 2018

Canine oral fibrosarcoma: Changes in prognosis over the last 30 years?

Vet J 2018 Nov 5;241:1-7. Epub 2018 Sep 5.

Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.

Canine oral fibrosarcoma (oFSA) is a malignant, infiltrating, mesenchymal tumour affecting the oral cavity primarily of medium to large middle aged dogs. The diagnosis often is made late in the course of the disease, due to the frequent caudal location of the tumour, and histopathology is not always sufficient to discriminate undifferentiated oFSA from other poorly differentiated malignant mesenchymal tumours occurring at the same site, especially in small biopsy samples. The literature exclusively relating to oFSA is limited and outcome data following treatment are difficult to compare. Read More

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November 2018
4 Reads

Clinical and radiographic presentation of pelvic sarcoma in children.

SICOT J 2018 19;4:44. Epub 2018 Oct 19.

Department of Orthopaedics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Introduction: Pelvic sarcomas may present with vague symptoms. The aim of this study was to examine the characteristics and clinical presentations of different types of pelvic sarcoma in children.

Methods: This is a retrospective cohort study of patients up to 21 years of age with the diagnosis of pelvic sarcoma between January 2000 and June 2013. Read More

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October 2018
6 Reads

In Vivo Molecular Imaging Using Low-Boiling-Point Phase-Change Contrast Agents: A Proof of Concept Study.

Ultrasound Med Biol 2019 Jan 11;45(1):177-191. Epub 2018 Oct 11.

Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, North Carolina, USA. Electronic address:

Sub-micron phase-change contrast agents (PCCAs) have been proposed as a tool for ultrasound molecular imaging based on their potential to extravasate and target extravascular markers and also because of the potential to image these contrast agents with a high contrast-to-tissue ratio. We compare in vivo ultrasound molecular imaging with targeted low-boiling-point PCCAs and targeted microbubble contrast agents. Both agents were targeted to the intravascular (endothelial) integrin αßvia a cyclic RGD peptide (cyclo-Arg-Gly-Asp-D-Tyr-Cys) mechanism and imaged in vivo in a rodent fibrosarcoma model, which exhibits angiogenic microvasculature. Read More

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January 2019

RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression.

Proc Natl Acad Sci U S A 2018 10 11;115(44):E10352-E10361. Epub 2018 Oct 11.

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721;

NRF2 regulates cellular redox homeostasis, metabolic balance, and proteostasis by forming a dimer with small musculoaponeurotic fibrosarcoma proteins (sMAFs) and binding to antioxidant response elements (AREs) to activate target gene transcription. In contrast, NRF2-ARE-dependent transcriptional repression is unreported. Here, we describe NRF2-mediated gene repression via a specific seven-nucleotide sequence flanking the ARE, which we term the NRF2-replication protein A1 (RPA1) element (NRE). Read More

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October 2018
1 Read

Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):577-579

Department of Histopathology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.

Pure mesenchymal sarcomas and phyllodes tumor with sarcomatous differentiation of the breast are rare tumors. Primary breast sarcomas are a heterogenous group of neoplasms which include malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Sarcomatous differentiation in phyllodes tumor is seen in the form of angiosarcoma, chondrosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Read More

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October 2018
2 Reads

[Dermatofibrosarcoma: Management].

Bull Cancer 2018 Nov 5;105(11):1094-1101. Epub 2018 Oct 5.

Centre Oscar Lambret, département de cancérologie générale, 3, rue F. Combemale, 59020 Lille, France.

Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). Read More

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November 2018
2 Reads

Adjacent skin rotation flap for large defect in primary breast tumor.

J Surg Oncol 2018 Dec 7;118(7):1199-1204. Epub 2018 Oct 7.

Department of Breast Surgery, Hubei Cancer Hospital, Wuhan, China.

Backgrounds: Surgical resection of large primary breast tumor often results in large chest wall defects. The purpose of this study is to evaluate the feasibility of using adjacent skin rotation (ASR) flap in patients with giant primary breast tumor.

Methods: A total of 26 giant primary breast tumor patients treated with ASR flap were included in this study. Read More

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December 2018
8 Reads

HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.

Mol Oncol 2018 Oct 5. Epub 2018 Oct 5.

Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.

Poly(ADP-ribose) polymerase 1 inhibitors alone or in combination with DNA damaging agents are promising clinical drugs in the treatment of cancer. However, there is a need to understand the molecular mechanisms of resistance to PARP1 inhibitors. Expression of HMGA2 in cancer is associated with poor prognosis for patients. Read More

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October 2018
1 Read

Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature.

Glob Pediatr Health 2018 1;5:2333794X18803552. Epub 2018 Oct 1.

Wayne State University, Detroit, MI, USA.

Newborn skin nodules are usually benign and self-resolving skin condition. Differential diagnosis of such lesions include cysts, hemangioma, abscess, cellulitis, sclerema neonatorum, subcutaneous fat necrosis, neurofibromatosis, benign tumors, or malignant tumors such as rhabdomyosarcoma, infantile fibrosarcoma, or neuroblastoma. We report a case of congenital subcutaneous fat necrosis in a 7-day-old baby presenting with multiple erythematous mass on back. Read More

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October 2018
6 Reads

Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice.

Diabetologia 2018 12 3;61(12):2608-2620. Epub 2018 Oct 3.

Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Aims/hypothesis: Epigenetic regulation of gene expression has been implicated in the pathogenesis of obesity and type 2 diabetes. However, detailed information, such as key transcription factors in pancreatic beta cells that mediate environmental effects, is not yet available.

Methods: To analyse genome-wide cis-regulatory profiles and transcriptome of pancreatic islets derived from a diet-induced obesity (DIO) mouse model, we conducted chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) of histone H3 lysine 27 acetylation (histone H3K27ac) and high-throughput RNA sequencing. Read More

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December 2018
7 Reads

Preparation and biological evaluation of a novel pH-sensitive poly (β-malic acid) conjugate for antitumor drug delivery.

Int J Mol Med 2018 Dec 25;42(6):3495-3502. Epub 2018 Sep 25.

Department of Pharmaceutical Analysis, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.

Poly (β‑malic acid), referred to as PMLA, has been synthesized and introduced as a polymeric drug carrier due to its desirable biological properties. In the present study, a novel pH‑sensitive polymer‑drug conjugate based on PMLA, PMLA‑Hz‑doxorubicin (DOX), was prepared, and another conjugate, PMLA‑ami‑DOX, was synthesized as a comparison. The structures, conjugation efficiency, and drug release properties of the prodrugs were determined. Read More

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December 2018
9 Reads

Deepened cellular/subcellular interface penetration and enhanced antitumor efficacy of cyclic peptidic ligand-decorated accelerating active targeted nanomedicines.

Int J Nanomedicine 2018 19;13:5537-5559. Epub 2018 Sep 19.

Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing, 100191, China.

Introduction: Acceleration and improvement of penetration across cell-membrane interfaces of active targeted nanotherapeutics into tumor cells would improve tumor-therapy efficacy by overcoming the issue of poor drug penetration. Cell-penetrating peptides, especially synthetic polyarginine, have shown promise in facilitating cargo delivery. However, it is unknown whether polyarginine can work to overcome the membrane interface in an inserted pattern for cyclic peptide ligand-mediated active targeting drug delivery. Read More

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November 2018
3 Reads

[Application of gastric tube esophagoplasty to complicated diseases of esophagus in children].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Sep;21(9):1025-1031

Department of Thoracic Surgery, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.

Objective: To summarize the experience of applying gastric tube esophagoplasty for complicated diseases of esophagus in children and the short-middle-term efficacy.

Methods: A retrospective and observational case series study was performed.

Inclusion Criteria: (1) burn length of esophagus > 2 cm, multisegmental or extensive esophageal scar stenosis, and about 6 months after burn; (2) longitudinal diameter of esophageal tumor > 2 cm, or esophagus considered as impossible to reserve;(3) Severe esophageal fistula with diameter > 2 cm, or relapse again after ≥3 times of repair; (4) Tracheal cartilaginous esophageal heterotopia with a length of >2 cm or no end to end anastomosis after removal of the esophageal lesion. Read More

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September 2018
8 Reads

The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts.

Biochem Biophys Res Commun 2018 Oct 18;505(1):74-80. Epub 2018 Sep 18.

Department of Cosmetic Health Science, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan. Electronic address:

We have previously reported that HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/KIAA1199/CEMIP) is a specific HA-binding protein that is essential for HA depolymerization in skin and synovial fibroblasts. HA is incorporated into cells in the presence of HYBID and clathrin, degraded in endosomes, and excreted into the extracellular space. However, it is not yet clear whether HYBID itself catalytically cleaves HA. Read More

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October 2018

Triggered radiosensitizer delivery using thermosensitive liposomes and hyperthermia improves efficacy of radiotherapy: An in vitro proof of concept study.

PLoS One 2018 18;13(9):e0204063. Epub 2018 Sep 18.

Center of Imaging Sciences, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: To increase the efficacy of chemoradiation and decrease its toxicity in normal tissue, a new concept is proposed, local radiosensitizer delivery, which combines triggered release of a radiosensitizer from thermosensitive liposomes with local hyperthermia and radiotherapy. Here, key aspects of this concept were investigated in vitro I) the effect of hyperthermia on the enhancement of radiotherapy by ThermoDox (thermosensitive liposome containing doxorubicin), II) the concentration dependence of the radiosensitizing effect of doxorubicin and III) the sequence of doxorubicin, hyperthermia and radiotherapy maximizing the radiosensitizing effect.

Methods: Survival of HT1080 (human fibrosarcoma) cells was measured after exposure to ThermoDox or doxorubicin for 60 minutes, at 37 or 43°C, with or without irradiation. Read More

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September 2018

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma.

Br J Cancer 2018 Sep 17;119(6):693-696. Epub 2018 Sep 17.

Children's Cancer Institute, UNSW, Sydney, NSW, Australia.

Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the first case of a TRK fusion-driven HGG treated with larotrectinib-the first selective pan-TRK inhibitor in clinical development. Read More

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September 2018
1 Read

Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents.

Eur J Med Chem 2018 Oct 6;158:144-166. Epub 2018 Sep 6.

Center for Biomaterials, Korea Institute of Science & Technology (KIST), Seoul, Seongbuk-gu, 02792, Republic of Korea; Department of Biomolecular Science, University of Science & Technology (UST), Daejeon, Yuseong-gu, 34113, Republic of Korea. Electronic address:

Frequent oncogenic mutations have been identified in MAPK (mitogen-activated protein kinase) signaling pathway components. As a result, MAPK pathway is associated with human cancer initiation, in particular RAF (rapidly accelerated fibrosarcoma) component. The mutation in RAF component leads to auto-activation of MAPK signaling pathway, stimulating the uncontrolled cell growth and proliferation. Read More

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October 2018

Feline Injection Site Sarcomas: Data from Switzerland 2009-2014.

J Comp Pathol 2018 Aug 18;163:1-5. Epub 2018 Jul 18.

Collegium Helveticum, Universität Zürich und Eidgenössische Technische Hochschule Zürich, Switzerland; Institut für Veterinärpathologie Vetsuisse Fakultät Universität Zürich, Zurich, Switzerland.

Feline injection site sarcomas (FISS) were first described in the early 1990s. Despite extensive research, the pathogenesis of these tumours has not been elucidated conclusively. Their appearance and the marked increase in their incidence has been mainly connected to the injection of vaccines, and it is assumed that a chronic inflammatory reaction at the injection site triggers subsequent malignant transformation. Read More

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August 2018
7 Reads

TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination.

Proc Natl Acad Sci U S A 2018 10 12;115(41):10440-10445. Epub 2018 Sep 12.

Protein and Nucleic Acid Chemistry Division, Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;

Adenovirus has enormous potential as a gene-therapy vector, but preexisting immunity limits its widespread application. What is responsible for this immune block is unclear because antibodies potently inhibit transgene expression without impeding gene transfer into target cells. Here we show that antibody prevention of adenoviral gene delivery in vivo is mediated by the cytosolic antibody receptor TRIM21. Read More

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October 2018
4 Reads

The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas.

Cancer 2018 Nov 11;124(21):4241-4247. Epub 2018 Sep 11.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: The highly selective oral tropomyosin receptor kinase (TRK) inhibitor larotrectinib has demonstrated significant activity in adult and pediatric TRK fusion cancers. In the current study, the authors describe the clinical course of children with locally advanced TRK fusion sarcoma who were treated preoperatively with larotrectinib and underwent subsequent surgical resection.

Methods: A total of 24 children were treated on a pediatric phase 1 trial of larotrectinib (ClinicalTrials. Read More

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November 2018
4 Reads

Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line.

J Cell Physiol 2018 Sep 6. Epub 2018 Sep 6.

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Cerium oxide nanoparticles are associated with anticancer effects. While protecting normal cells, these nanoparticles exert their anticancer effects via oxidative stress and apoptosis in the cancer cells. In this study, the anticancer properties of nanoceria on fibrosarcoma cell line are evaluated. Read More

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September 2018
2 Reads

Clinical Characteristics and efficacy of chemotherapy in sclerosing epithelioid fibrosarcoma.

Med Oncol 2018 Sep 5;35(11):138. Epub 2018 Sep 5.

Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.

Background: Sclerosing epithelioid fibrosarcoma (SEF) is a very rare soft tissue sarcoma subtype. Clinically it is an aggressive tumour; however, to our knowledge there are no published reports regarding the efficacy of chemotherapy in SEF. Therefore, the aim of this study was to document the outcome of a series of patients with SEF treated at a single referral centre with reference to systemic therapy. Read More

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September 2018

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.

Virchows Arch 2018 Sep 6. Epub 2018 Sep 6.

Department of Dermatology, Unit of Pediatric Dermatology - CHRU Tours, Tours, France.

Cutaneous spindle-cell neoplasms in adults as well as children represent a frequent dilemma for pathologists. Along this neoplasm spectrum, the differential diagnosis with CD34-positive proliferations can be challenging, particularly concerning neoplasms of fibrohistiocytic and fibroblastic lineages. In children, cutaneous and superficial soft-tissue neoplasms with CD34-positive spindle cells are associated with benign to intermediate malignancy potential and include lipofibromatosis, plaque-like CD34-positive dermal fibroma, fibroblastic connective tissue nevus, and congenital dermatofibrosarcoma protuberans. Read More

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September 2018
8 Reads
2.650 Impact Factor