17,277 results match your criteria Fibrosarcoma


miR-197-5p inhibits sarcomagenesis and induces cellular senescence via repression of KIAA0101.

Mol Carcinog 2019 Apr 18. Epub 2019 Apr 18.

RNAi and Functional Genomics Lab, Department of Life Science, National Institute of Technology, Rourkela, Odisha, India.

The abnormal expressions of microRNAs (miRNAs) are known to be associated with various pathophysiological processes that lead to the development of a plethora of diseases including cancer. Among several miRNAs studied so far, miR-197 has been reported to play a vital role either as an oncogene or tumor suppressor in different cancers. However, its role in carcinogenesis of fibrosarcoma has not yet been elucidated. Read More

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http://dx.doi.org/10.1002/mc.23021DOI Listing

Protein-programmed accumulation of yeast cytosine deaminase in cancer cells in response to mock-hypoxia.

ACS Synth Biol 2019 Apr 18. Epub 2019 Apr 18.

One limitation of gene-directed enzyme prodrug therapy (GDEPT) is the difficulty in selectively and efficiently transducing cancer cells with the gene encoding a prodrug-converting enzyme. To circumvent this issue, we sought to move the selectivity from the gene delivery level to the protein level. We developed fusion proteins of the prodrug-activating enzyme yeast cytosine deaminase (yCD) and the oxygen-dependent degradation domain (ODDD) of HIF-1α, a domain that regulates the accumulation of HIF-1α in an oxygen-dependent manner. Read More

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http://dx.doi.org/10.1021/acssynbio.9b00036DOI Listing

Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, UNITED STATES.

Most solid tumors are characterized by highly dense, isotropic vessel networks. Characterization of such features has shown promise for early cancer diagnosis. Ultrasound diffusion has been used to characterize the micro-architecture of complex media, such as bone and the lungs. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1a44
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http://dx.doi.org/10.1088/1361-6560/ab1a44DOI Listing
April 2019
1 Read

Synthesis of Gold(I) Complexes Containing Cinnamide: In Vitro Evaluation of Anticancer Activity in 2D and 3D Spheroidal Models of Melanoma and In Vivo Angiogenesis.

Inorg Chem 2019 Apr 15. Epub 2019 Apr 15.

Centre for Advanced Materials & Industrial Chemistry, School of Science , RMIT University , G.P.O. Box 2476, Melbourne 3001 , Australia.

A series of alkynylgold(I) phosphine complexes containing methoxy-substituted cinnamide moieties (3a-3c and 4a-4c) have been synthesized and characterized. All of the synthesized complexes were evaluated for their cytotoxicity against three human cancer cell lines A549 (lung), D24 (melanoma), and HT1080 (fibrosarcoma) and the human embryonic kidney 293 cell line (Hek293T) as a proxy model for noncancer cells. Most of the synthesized compounds showed antiproliferative activity against cancer cell lines at low micromolar concentrations. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00281DOI Listing
April 2019
1 Read

Prolonged Response Induced by Single Agent Vemurafenib in a Spinal Ganglioglioma: A Case Report and Review of the Literature.

Front Oncol 2019 26;9:177. Epub 2019 Mar 26.

Department of Medical Oncology, University Hospital of Besançon, Besançon, France.

Spinal ganglioglioma is a rare low-grade, slow-growing tumor of the central nervous system affecting mostly children and young adults. After surgery, some patients show tumor recurrence and/or malignant transformation. Gangliogliomas harbor molecular deficiencies such as mutations in the B-rapidly accelerated fibrosarcoma () gene, resulting in activation of a downstream signaling pathway and cancer development. Read More

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http://dx.doi.org/10.3389/fonc.2019.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448025PMC

Resection margins obtained with patient-specific instruments for resecting primary pelvic bone sarcomas: A case-control study.

Orthop Traumatol Surg Res 2019 Apr 11. Epub 2019 Apr 11.

Neuro Musculo-Skeletal Laboratory (NMSK), secteur des sciences de la santé, institut de recherche expérimentale et clinique, université catholique de Louvain, avenue Mounier 53, 1200 Brussels, Belgium; Service d'orthopédie et de traumatologie de l'appareil locomoteur, cliniques universitaires Saint-Luc, avenue Hippocrate 10, 1200 Brussels, Belgium; Cancérologie et hématologie, institut Roi-Albert-II, cliniques universitaires Saint-Luc, avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address:

Background: Limb salvage surgery for pelvic bone sarcoma carries a very high risk of local recurrence. Patient-specific instruments (PSIs) have shown promise for obtaining tumour-free resection margins. However, no data are available on medium-term outcomes including local recurrence rates after PSI-guided resection. Read More

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http://dx.doi.org/10.1016/j.otsr.2018.12.016DOI Listing

Physiological levels of chromogranin A prevent doxorubicin-induced cardiotoxicity without impairing its anticancer activity.

FASEB J 2019 Apr 11:fj201802707R. Epub 2019 Apr 11.

Laboratory of Cellular and Molecular Cardiac Pathophysiology, Department of Biology, Ecology, and Earth Science, University of Calabria, Rende (Cosenza), Italy.

The clinical use of doxorubicin (Doxo), a widely used anticancer chemotherapeutic drug, is limited by dose-dependent cardiotoxicity. We have investigated whether chromogranin A (CgA), a cardioregulatory protein released in the blood by the neuroendocrine system and by the heart itself, may contribute to regulation of the cardiotoxic and antitumor activities of Doxo. The effects of a physiologic dose of full-length recombinant CgA on Doxo-induced cardiotoxicity and antitumor activity were investigated in rats using in vivo and ex vivo models and in murine models of melanoma, fibrosarcoma, lymphoma, and lung cancer, respectively. Read More

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http://dx.doi.org/10.1096/fj.201802707RDOI Listing
April 2019
1 Read

Arf6, JIP3 and Dynein shape and mediate Macropinocytosis.

Mol Biol Cell 2019 Apr 10:mbcE19010022. Epub 2019 Apr 10.

Cell and Developmental Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892.

Macropinocytosis is an actin-driven form of clathrin-independent endocytosis that generates an enlarged structure, the macropinosome. Although many studies focus on signaling molecules and phosphoinositides involved in initiating macropinocytosis, the commitment to forming a macropinosome and the handling of that membrane has not been studied in detail. Here we show in HT1080 cells, a human fibrosarcoma cell line, a requirement for microtubules, dynein, the JIP3 microtubule motor scaffold protein, and Arf6, a JIP3 interacting protein, for the formation and inward movement of the macropinosome. Read More

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https://www.molbiolcell.org/doi/10.1091/mbc.E19-01-0022
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http://dx.doi.org/10.1091/mbc.E19-01-0022DOI Listing
April 2019
7 Reads

Ameloblastic fibroma in a young adult.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):63-65

Department of Oral and Maxillofacial Surgery, KCDS, Bengaluru, Karnataka, India.

Ameloblastic fibroma is a rare mixed odontogenic tumor of the jaw comprising 2.5% of all odontogenic tumors. It is most commonly seen in young adults as a gradually increasing swelling in the jaw. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_37_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421916PMC
February 2019

Estrogen producing ovarian fibrosarcoma: A case report.

Nagoya J Med Sci 2019 Feb;81(1):171-176

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Fibrosarcoma is an extremely rare malignant sex-cord stromal tumor. Fibrosarcoma is generally unknown as an estrogen producing tumor. This report presents, for the first time, a case of estrogen producing ovarian fibrosarcoma in an 83-year-old female. Read More

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http://dx.doi.org/10.18999/nagjms.81.1.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433630PMC
February 2019

High-Throughput Three-Dimensional Hydrogel Cell Encapsulation Assay for Measuring Matrix Metalloproteinase Activity.

Assay Drug Dev Technol 2019 Apr;17(3):100-115

1 Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio.

Three-dimensional (3D) cell culture systems more closely mimic the in vivo cellular microenvironment than traditional two-dimensional cell culture methods, making them a valuable tool in drug screening assays. However, 3D environments often make analysis of cellular responses more difficult, so most high-throughput (HT) 3D assays have been limited to measurements of cell viability. Yet, many other cell functions contribute to disease and are important pharmacological targets. Read More

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http://dx.doi.org/10.1089/adt.2018.877DOI Listing
April 2019
3 Reads

[Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):282-287

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinicopathological features, diagnosis and differential diagnosis of dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features. Five cases of DDLPS with IMT-like features were collected from the First Affiliated Hospital of Nanjing Medical University, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine and the First People's Hospital of Qinzhou between 2013 and 2018. EnVision method and fluorescence in situ hybridization (FISH) were used to detect the immunophenotype of the tumor cells and the profile of MDM2 gene amplification respectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.004DOI Listing
April 2019
1 Read

Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors.

J Inorg Biochem 2019 Mar 30;195:174-181. Epub 2019 Mar 30.

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. Electronic address:

In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase-1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.022DOI Listing

Dermatofibrosarcoma Protuberans on Adult Toes: A Case Report and Review of the Literature.

Anticancer Res 2019 Apr;39(4):2105-2111

Laboratory of Pathology, Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-grade, dermal soft-tissue neoplasm with high recurrence, but low metastatic potential. It mainly occurs on the trunk, proximal extremity, head and neck, but rarely on the toes. Herein we report a case of DFSP on the right hallux. Read More

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http://dx.doi.org/10.21873/anticanres.13323DOI Listing
April 2019
1 Read

A novel MAP3K7CL-ERG fusion in a molecularly confirmed case of dermatofibrosarcoma protuberans with fibrosarcomatous transformation.

J Cutan Pathol 2019 Apr 4. Epub 2019 Apr 4.

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, New Hampshire.

Dermatofibrosarcoma protuberans (DFSP) is a low-grade sarcoma with fibroblastic differentiation characterized, in the great majority of cases, by fusions between the COL1A1 and PDGFB genes. In some instances, transformation to a genetically more complex sarcoma, most commonly fibrosarcoma, is observed. However, the molecular pathogenesis of this transformation is not well understood. Read More

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http://dx.doi.org/10.1111/cup.13469DOI Listing
April 2019
2 Reads

Ameloblastic Fibrosarcoma in Pregnancy: an Unreported Entity!

Indian J Surg Oncol 2019 Mar 28;10(1):180-183. Epub 2018 Nov 28.

1Department of Surgical Oncology, Chittaranjan National Cancer Institute (CNCI), 37 SP Mukherjee Road, Kolkata, West Bengal 700026 India.

AFS is a rare tumor of odontogenic origin. Less than 100 cases have been reported so far in the literature. Due to its extreme rarity, we do not have clear management guidelines at present. Read More

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http://dx.doi.org/10.1007/s13193-018-0843-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414559PMC
March 2019
2 Reads

C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells.

Int J Oncol 2019 Apr 1. Epub 2019 Apr 1.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa 223‑8522, Japan.

R‑spondin2 (Rspo2), one of the four members of the R‑spondin family of proteins, has agonistic activity in the Wnt/β‑catenin signaling pathway, and it is associated with normal development, as well as disease, such as cancer. The present study focused on the C‑mannosylation of Rspo2, which is a novel and unique type of glycosylation that occurs via a C‑C linkage between the tryptophan residue and an α‑mannose. Although Rspo2 has two putative C‑mannosylation sites at residues Trp150 and Trp153, it had not been reported to date whether these sites are C‑mannosylated. Read More

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http://dx.doi.org/10.3892/ijo.2019.4767DOI Listing

S100 and CD34 positive spindle cell tumor with prominent perivascular hyalinization and a novel NCOA4-RET fusion.

Genes Chromosomes Cancer 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic.

We report a case of a 35-year old male patient with a tumor located in the deep dermis on his forearm. The lesion was completely excised but recurred 4 years later. The patient showed no signs of neurofibromatosis type 1. Read More

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http://dx.doi.org/10.1002/gcc.22758DOI Listing
April 2019
7 Reads

Dermatofibrosarcoma protuberans: clinicopathologic presentation in Nigerians.

Pan Afr Med J 2018 12;31:25. Epub 2018 Sep 12.

Department of Oral and Maxillofacial Surgery, College of Medicine University of Lagos, Nigeria.

Introduction: Dermatofibrosarcoma protuberance (DFSP) is in general a rare low grade malignant sarcoma and possesses a tendency for local recurrence. It has a site predilection for the trunk. Occurrence in the facial area is extremely rare. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.25.13665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430858PMC
April 2019
1 Read

Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma.

Drug Dev Res 2019 Mar 22. Epub 2019 Mar 22.

Department of Preclinical Sciences, OndokuzMayıs University, Faculty of Veterinary Medicine, Samsun, Turkey.

The main challenges in treating cancer using chemotherapeutics are insufficient dose at the target site and the development of drug resistance, while higher doses can induce side effects by damaging nontarget tissues. Combinatorial drug therapy may overcome these limitations by permitting lower doses and more specific targeting, thereby mitigating drug resistance and nontarget side effects. Recent reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer potential and can be used together with conventional chemotherapeutics to improve efficacy and safety. Read More

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http://dx.doi.org/10.1002/ddr.21530DOI Listing
March 2019
2 Reads

Reprogramming of CaCo2 colorectal cancer cells after using the complex of poly-(N-vinylpyrrolidone) with small non-coding RNAs.

Toxicol Rep 2019 15;6:186-192. Epub 2019 Feb 15.

Department of Biomaterials, D.I. Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow, 125047, Russia.

Small non-coding RNAs control normal development and differentiation in the embryo. These regulatory molecules play a key role in the development of human diseases and are used often today for researching new treatments for different pathologies. In this study, CaCo2 colorectal adenocarcinoma cells were initially epigenetically reprogrammed and transformed into CD4+ cells with nano-sized complexes of amphiphilic poly-(N-vinylpyrrolidone) () with miRNA-152 and piRNA-30074. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405903PMC
February 2019

Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms.

Mod Pathol 2019 Mar 16. Epub 2019 Mar 16.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

Mesenchymal neoplasms of the uterus (corpus and cervix) encompass a heterogeneous group of tumors with differing morphologies, immunophenotypes and molecular alterations. With the advent of modern molecular techniques, such as next generation sequencing, newly defined genetic abnormalities are being reported in this group of neoplasms. Herein we report the clinicopathological and molecular features of a series of 13 spindle cell sarcomas of the uterus and vagina (10 cervix, 2 uterine corpus, 1 vagina) with morphology resembling fibrosarcoma. Read More

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http://www.nature.com/articles/s41379-018-0184-6
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http://dx.doi.org/10.1038/s41379-018-0184-6DOI Listing
March 2019
5 Reads
6.187 Impact Factor

Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(-Alkylpyridinium)-1,4-Dihydropyridines.

Pharmaceutics 2019 Mar 12;11(3). Epub 2019 Mar 12.

Latvian Institute of Organic Synthesis, Aizkraukles str. 21, Riga LV-1006, Latvia.

The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. Read More

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http://dx.doi.org/10.3390/pharmaceutics11030115DOI Listing
March 2019
2 Reads

Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells.

Oncol Lett 2019 Mar 29;17(3):3555-3561. Epub 2019 Jan 29.

Department of Radiation Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Aomori 036-8564, Japan.

Tumor recurrence and distant metastasis following radiotherapy, which can lead to poor prognosis, are caused by residual cancer cells that acquire radioresistance. Chemotherapy or a combination of targeted inhibitors can potentially enhance radiation sensitivity and prevent metastasis. It was previously reported that co-administration of the hyaluronan synthesis inhibitor 4-methylumbelliferone (4-MU) enhanced the lethality of X-ray irradiation in HT1080 human fibrosarcoma cells and decreased their invasiveness to a greater extent than either treatment alone. Read More

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http://dx.doi.org/10.3892/ol.2019.9990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396223PMC

Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases.

Vet Pathol 2019 Mar 11:300985819829522. Epub 2019 Mar 11.

1 Department Animal Medicine, Surgery and Pathology, Veterinary Medicine School, Complutense University of Madrid (UCM), Madrid, Spain.

Canine spindle cell mammary tumor (CSCMT) is an infrequent canine mammary tumor (CMT) composed of spindle or fusiform cells, which represents a challenge for pathologists and clinicians. Mammary tumors submitted for histopathology from 1998 to 2013 and compatible with CSCMTs were retrospectively selected. The tumors were diagnosed based on the hematoxylin and eosin (HE)-stained section; malignant tumors were graded using a canine soft tissue sarcoma grading scheme and a canine mammary tumor grading scheme, and they were further assigned a diagnosis based on immunohistochemistry (IHC) for pancytokeratin, cytokeratin 14, p63, calponin, vimentin, Ki-67, CD31, desmin, myosin, smooth muscle actin, glial fibrillary acidic protein, and S-100. Read More

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http://dx.doi.org/10.1177/0300985819829522DOI Listing
March 2019
3 Reads

SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.

Cell Signal 2019 Mar 4;59:1-12. Epub 2019 Mar 4.

Collaborative Research Center, Shanghai University of Medicine and Health Sciences, Shanghai, China; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China. Electronic address:

Human SLFN5 inhibits invasions of IFNα-sensitive renal clear-cell carcinoma and melanoma cells. However, whether this inhibition is confined to these IFNα-sensitive cancers is unclear. Here we show that SLFN5 expressions on both mRNA and protein levels are significantly higher in non/low-invasive cancer cell lines (breast cancer cell line MCF7, colorectal cancer cell line HCT116 and lung cancer cell line A549) than in highly-invasive cancer cell lines (fibrosarcoma cell line HT1080 and renal clear cell cancer cell line 786-0). Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.03.004DOI Listing

Primary sclerosing epithelioid fibrosarcoma of the kidney: Report of two additional cases with a clinicopathological and molecular cytogenetic study.

Exp Mol Pathol 2019 04 27;107:179-183. Epub 2019 Feb 27.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

We present two cases of sclerosing epithelioid fibrosarcoma (SEF) that arose primarily in the kidney. The tumor in both cases was located at the upper pole of the kidney. Clincially, they were suspected as renal cell carcinomas. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.02.006DOI Listing
April 2019
2 Reads

Paraneoplastic disorders associated with miscellaneous neoplasms with focus on selected soft tissue and Undifferentiated/ rhabdoid malignancies.

Authors:
Abbas Agaimy

Semin Diagn Pathol 2019 Feb 20. Epub 2019 Feb 20.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Germany. Electronic address:

A variety of soft tissue and visceral neoplasms have been associated with constitutional symptoms and signs including fever, fatigue, arthritis and laboratory abnormalities such as elevated erythrocyte sedimentation rate, leukocytosis with marked neutrophilia, anemia, thrombocytosis and others. This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions). Read More

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http://dx.doi.org/10.1053/j.semdp.2019.02.001DOI Listing
February 2019
2 Reads

Poly(d,l-lactide)/polyethylene glycol micro/nanofiber mats as paclitaxel-eluting carriers: preparation and characterization of fibers, in vitro drug release, antiangiogenic activity and tumor recurrence prevention.

Mater Sci Eng C Mater Biol Appl 2019 May 14;98:982-993. Epub 2019 Jan 14.

Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. Electronic address:

Poly(d,l-lactide)/polyethylene glycol (PLA/PEG) micro/nanofibers loaded with paclitaxel (PTX, 10 wt%) were prepared by needless electrospinning technology, which allows large scale production for real medicinal practice. The fiber structure and properties were investigated by several methods including scanning electron microscopy, nitrogen adsorption/desorption isotherm measurements, differential scanning calorimetry, and X-ray diffraction measurements to examine their morphology (fiber diameter distribution, specific surface area, and total pore volume), composition, drug-loading efficiency, and physical state. An HPLC-UV method was optimized and validated to quantify in vitro PTX release into PBS. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.046DOI Listing
May 2019
1 Read

Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer.

J Environ Pathol Toxicol Oncol 2019 ;38(1):51-59

Shandong University, Cheeloo College of Medicine, Jinan, Shandong Province, 250012, China.

The eukaryotic cell cycle via mitogen-activated protein kinase (MAPK) has been considered as an effective signaling cascade pathway for anticancer therapy. In addition to the MAPK signaling pathway, the Rat Sarcoma Virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MAPK-ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is a signaling cascade that has a crucial role to play in cell survival and development of cancer, especially breast cancer. Novel drugs and clinical trials need to be investigated, taking into consideration the already studied genetic defects related to genesis of tumors in certain populations. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2018028386DOI Listing

Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-κB and GFAP in spinal astrocytes in a mouse model.

Int J Neurosci 2019 Feb 26:1-8. Epub 2019 Feb 26.

b Department of Anesthesiology , The First Hospital of Shijiazhuang , Shijiazhuang , China.

Aim: Thalidomide is one of the first line therapies in cancer pain management. Previous study has shown that thalidomide decreases the expression of tumor necrosis factor alpha in the mouse spinal cord. However, the exact cellular and molecular mechanism underlying the effect of thalidomide remains unclear. Read More

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http://dx.doi.org/10.1080/00207454.2019.1586687DOI Listing
February 2019
4 Reads

Cervical congenital infantile fibrosarcoma: a case report.

J Med Case Rep 2019 Feb 24;13(1):41. Epub 2019 Feb 24.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Congenital infantile fibrosarcoma is a rare mesenchymal tumor seen in children as well as adults. The congenital variety is rare and out of the reported cases only one case sited in the neck has been reported so far. Another such case is presented here who was successfully managed. Read More

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http://dx.doi.org/10.1186/s13256-019-1968-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387739PMC
February 2019

4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate.

J Antibiot (Tokyo) 2019 05 22;72(5):271-281. Epub 2019 Feb 22.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.

4-O-Methylascochlorin (MAC), a methylated derivative of ascochlorin, was previously shown to promote the accumulation of hypoxia-inducible factor (HIF)-1α in human breast adenocarcinoma MCF-7 cells. In the present study, we further investigated the effects of MAC on the expression and function of HIF-1α in human fibrosarcoma HT-1080 cells. MAC promoted the accumulation of the HIF-1α protein without affecting its constitutive mRNA expression and augmented the transcriptional activation of HIF target genes. Read More

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http://dx.doi.org/10.1038/s41429-019-0157-0DOI Listing

Iron-oxide nanoparticles target intracellular HSP90 to induce tumor radio-sensitization.

Biochim Biophys Acta Gen Subj 2019 May 20;1863(5):857-869. Epub 2019 Feb 20.

Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400085, India. Electronic address:

Background: Nanoparticle-based therapies have emerged as a promising approach to overcome limitations of conventional chemotherapy. Present study investigates the potential of oleic acid-functionalized iron-oxide nanoparticles (MN-OA) to enhance the radiation response of fibrosarcoma tumor and elucidates its underlying mechanism.

Methods: Various cellular and molecular assays (e. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.010DOI Listing
May 2019
4.381 Impact Factor

Defining rules for cancer cell proliferation in TRAIL stimulation.

NPJ Syst Biol Appl 2019 15;5. Epub 2019 Feb 15.

2Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan.

Owing to their self-organizing evolutionary plasticity, cancers remain evasive to modern treatment strategies. Previously, for sensitizing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant human fibrosarcoma (HT1080), we developed and validated a dynamic computational model that showed the inhibition of protein kinase (PK)C, using bisindolylmaleimide (BIS) I, enhances apoptosis with 95% cell death. Although promising, the long-term effect of remaining ~ 5% cells is a mystery. Read More

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http://dx.doi.org/10.1038/s41540-019-0084-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377620PMC
February 2019

Collapsed wall: destructive and reconstructive surgery of anterior abdominal wall tumour in a young girl.

J Surg Case Rep 2019 Feb 8;2019(2):rjy345. Epub 2019 Feb 8.

Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kota Bharu, Malaysia.

Natural history of abdominal wall soft tissue sarcoma is still poorly understood due to its rarity. In unpublished data of our institution, only seven cases of abdominal wall soft sarcoma with ICD-10 coding of 49.4 were found for past 10 years. Read More

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http://dx.doi.org/10.1093/jscr/rjy345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368141PMC
February 2019
1 Read

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 15.

Burke Neurological Institute, White Plains, New York 10605.

Ferroptotic death is a mechanism for tumor suppression by pharmacological inhibitors that target the X transporter (cystine/glutamate antiporter) in a host of non-CNS and CNS tumors. Inhibition of this transporter leads to reduction of cystine uptake, cyst(e)ine deprivation, subsequent depletion of the versatile antioxidant glutathione, and reactive lipid species-dependent death. Accordingly, pharmacological inhibitors of the X transporter can also induce neuronal cell death raising concerns about toxicity in the CNS and PNS if these agents are used for chemotherapy. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0263-18.2019
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http://dx.doi.org/10.1523/ENEURO.0263-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378329PMC
February 2019
5 Reads

Vascular-endothelial response to IDH1 mutant fibrosarcoma secretome and metabolite: implications on cancer microenvironment.

Am J Cancer Res 2019 1;9(1):122-133. Epub 2019 Jan 1.

Laboratory of Cell Biology, Bergen County Academies 200 Hackensack Ave, Hackensack, NJ 07601, USA.

Isocitrate dehydrogenases (IDHs) are enzymes involved in the production of α-ketoglutarate (αkg) in normal cellular metabolism. Cells with IDH mutations reduce αkg to 2-hydroxyglutarate (2HG), an oncometabolite, and 2HG directly transforms normal cells to malignant cells through histone demethylation and epigenetic dysregulation. However, whether IDH mutations affect cancer stromal cells is elusive, and little is known whether 2HG may impact the tumor microenvironment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356916PMC
January 2019
1 Read

Evaluation of MMP Inhibitors Isolated from Fructus.

Molecules 2019 Feb 8;24(3). Epub 2019 Feb 8.

Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea.

The current study investigated the ability of two secoiridoids, GL-3 () and oleonuezhenide (), isolated from the fruits of to inhibit MMP-2 and -9 activity in phorbol 12-myristate 13-acetate (PMA)-induced HT-1080 human fibrosarcoma cells. Both compound and were able to exert lowered gelatin digestion activity for MMP-2 and -9 tested by gelatin zymography via suppressing the release of MMPs to culture medium according to ELISA results. Treatment with compounds was also able to suppress the expression of both mRNA and protein levels of MMP-2 and -9. Read More

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http://dx.doi.org/10.3390/molecules24030604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384611PMC
February 2019
4 Reads

Utilizing photosensitizing and radiosensitizing properties of TiO-based mitoxantrone imprinted nanopolymer in fibrosarcoma and melanoma cells.

Photodiagnosis Photodyn Ther 2019 Mar 6;25:472-479. Epub 2019 Feb 6.

Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Some materials such as TiO display a luminescence property when exposed to X-ray radiation. Therefore, a proper photosensitizer can induce photodynamic effects by absorbing the emitted photons from these materials during radiotherapy. In this way, the problem of limited photo- penetration depth in photodynamic therapy is resolved. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.006DOI Listing
March 2019
8 Reads
2.014 Impact Factor

A case of congenital infantile fibrosarcoma in a newborn.

Wiad Lek 2018;71(9):1844-1848

Department Of Pediatric №1, Vinnytsya National Pirogov Memorial Medical University, Vinnytsya, Ukraine.

Infantile fibrosarcoma is a malignant tumor, which is most common in infants, preferentially localized in the lower limbs. An important prognostic factor of the disease is early diagnostics, both clinical and instrumental. The operative treatment of infantile fibrosarcoma is a leading treatment method. Read More

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January 2018

Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis.

Nanomedicine (Lond) 2019 01 6;14(2):169-182. Epub 2018 Dec 6.

Mallinckrodt Institute of Radiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.

Aim: CaCO nanoparticles (nano-CaCO) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO to noninvasively monitor pH modulation and subsequent tumor response.

Materials & Methods: We synthesized ferromagnetic core coated with CaCO (magnetite CaCO). Read More

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http://dx.doi.org/10.2217/nnm-2018-0302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369564PMC
January 2019

Long-term live cells observation of internalized fluorescent Fe@C nanoparticles in constant magnetic field.

J Nanobiotechnology 2019 Feb 6;17(1):27. Epub 2019 Feb 6.

Faculté de Médecine, Université François Rabelais, 37032, Tours, France.

Background: Theranostics application of superparamagnetic nanoparticles based on magnetite and maghemite is impeded by their toxicity. The use of additional protective shells significantly reduced the magnetic properties of the nanoparticles. Therefore, iron carbides and pure iron nanoparticles coated with multiple layers of onion-like carbon sheath seem to be optimal for biomedicine. Read More

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http://dx.doi.org/10.1186/s12951-019-0463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364403PMC
February 2019
2 Reads

Methioninase Gene Therapy.

Methods Mol Biol 2019 ;1866:173-197

AntiCancer, Inc., San Diego, CA, USA.

Recombinant methioninase (rMETase) derived from Pseudomonas putida targets the elevated methionine (MET) requirement of cancer cells (methionine dependence) and has shown efficacy against a variety of cancer types in mouse models. To enhance the efficacy of rMETase, we constructed the pLGFP-METSN retrovirus encoding the P. putida methioninase (METase) gene fused with the green fluorescent protein (GFP) gene. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_14DOI Listing
January 2019
5 Reads

Refractory and metastatic infantile fibrosarcoma harboring fusion shows complete and durable response to crizotinib.

Cold Spring Harb Mol Case Stud 2019 Feb 1;5(1). Epub 2019 Feb 1.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Infantile fibrosarcoma (IFS) is a rare soft-tissue sarcoma, which classically presents as an aggressive and rapidly enlarging tumor over the distal extremities of children in their first year of life. The presence of and gene rearrangement is characteristic of IFS, which can be detected on routine fluorescence in situ hybridization (FISH) testing. Patients with IFS typically respond well to surgical resection and chemotherapy and have an overall survival of ∼90%. Read More

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http://dx.doi.org/10.1101/mcs.a003376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371745PMC
February 2019
1 Read

Durotaxis by Human Cancer Cells.

Biophys J 2019 Feb 12;116(4):670-683. Epub 2019 Jan 12.

Cell Biology Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland. Electronic address:

Durotaxis is a type of directed cell migration in which cells respond to a gradient of extracellular stiffness. Using automated tracking of positional data for large sample sizes of single migrating cells, we investigated 1) whether cancer cells can undergo durotaxis; 2) whether cell durotactic efficiency varies depending on the regional compliance of stiffness gradients; 3) whether a specific cell migration parameter such as speed or time of migration correlates with durotaxis; and 4) whether Arp2/3, previously implicated in leading edge dynamics and migration, contributes to cancer cell durotaxis. Although durotaxis has been characterized primarily in nonmalignant mesenchymal cells, little is known about its role in cancer cell migration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063495193002
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http://dx.doi.org/10.1016/j.bpj.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382956PMC
February 2019
11 Reads

Update on Lipomatous Tumors with Emphasis on Emerging Entities, Unusual Anatomic Sites, and Variant Histologic Patterns.

Surg Pathol Clin 2019 Mar;12(1):21-33

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO, USA. Electronic address:

This article reviews the histologic patterns of spindle cell/pleomorphic lipoma, well-differentiated liposarcoma, and dedifferentiated liposarcoma in the context of both usual and atypical anatomic presentation. The utility of molecular and immunohistochemical diagnostic modalities to distinguish these entities is described. In addition, more recently described and controversial entities, including atypical spindle cell lipomatous tumor and anisometric cell lipoma, are discussed. Read More

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http://dx.doi.org/10.1016/j.path.2018.11.001DOI Listing
March 2019
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Design, Synthesis, and Cytotoxic Activity of 3-Aryl-N-hydroxy-2-(sulfonamido)propanamides in HepG2, HT-1080, KB, and MCF-7 Cells.

Chem Biodivers 2019 Apr 28;16(4):e1800646. Epub 2019 Mar 28.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, P. R. China.

A new series of (sulfonamido)propanamides (6a1-6a13, 6b1-6b15, 7c1-7c5, 6d1-6d5, 6e1-6e6) was designed and synthesized. All the synthesized compounds were characterized by NMR and mass spectrometry. The target compounds were evaluated for their in vitro cytotoxic activity against hepatocellular carcinoma (HepG2), fibrosarcoma (HT-1080), mouth epidermal carcinoma (KB), and breast adenocarcinoma (MCF-7) cell lines with the sulforhodamine B (SRB) assay, with gemcitabine and mitomycin C as positive controls. Read More

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http://dx.doi.org/10.1002/cbdv.201800646DOI Listing
April 2019
1 Read