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RNA Biol 2022 Jan;19(1):841-851

Department of Medical Engineering, University of South Florida, Tampa, FL, USA.

Germline-encoded pattern recognition receptors [PRRs] in mammalian cells function in the detection of molecular patterns associated with pathogen invasion or cellular damage. A PRR subset is activated by the atypical presence and location of double-stranded RNA [dsRNA] or its synthetic analogue polyinosinic-polycytidylic acid [poly(I:C)], triggering pro-inflammatory signalling and death in many cell types. Poly(I:C) has been tested as a sole or combination cancer therapy in preclinical studies and clinical trials. Read More

Pan Afr Med J 2022 22;41:234. Epub 2022 Mar 22.

Service de Radiothérapie, CHU Mohammed VI, Oujda, Maroc.

Dermatofibrosarcoma is a rare cancer, accounting for 0.01% of all cancers. We here report the case of a 44-year-old female patient presenting with the 5 recurrence of locally advanced Darier-Ferrand dermatofibrosarcoma, that progressed on many cycles of neoadjuvant therapy and required emergency radiotherapy with good response. Read More

Mol Biol Rep 2022 Jun 18. Epub 2022 Jun 18.

Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

Chimeric antigen receptor T (CAR-T) cell therapy procedure includes taking personal T cells and processing or genetic engineering using specific antigens and in vitro expanding and eventually infusing into the patient's body to unleash immune responses. Adoptive cell therapy (ACT) includes lymphocytes taking, in vitro selection and expansion and processing for stimulation or activation and infusion into the patient's body. Immune checkpoint inhibitors (ICIs), ACT and CAR-T cell therapies have demonstrated acceptable results. Read More

Surg Pathol Clin 2022 Jun 20;15(2):341-367. Epub 2022 May 20.

Biopathology Department, Anticancer Center, Institut Bergonié, Bordeaux, France; INSERM U 1218, Action Unit, Bordeaux, France; University of Bordeaux, Talence, France.

This article provides an update of the recent developments in mesenchymal tumors of lower genital tract. We focus on the characterization of recurrent molecular events in certain genital stromal tumors, for instance angiomyofibroblastomas and superficial myofibroblastomas. Moreover, fusions involving Tyrosine-kinases receptors (NTRK, FRFR1, RET, COL1A1-PDGFB) have been demonstrated in an emerging group of mesenchymal tumors characterized by a fibrosarcoma-like morphology and a predilection for uterine cervix of premenopausal women. Read More

Surg Oncol Clin N Am 2022 Jul;31(3):419-430

Maria Sklodowska-Curie National Research Institute of Oncology, Sarcoma and Melanoma, Roentgena 5, 02-781 Warszawa, Poland. Electronic address:

Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) are genomically complex tumors commonly diagnosed in the extremities or trunk of elderly patients. They likely represent a spectrum of disease differentiated by myxoid stroma and curvilinear vessels observed in MFS but not in UPS. Limb-sparing surgery is the standard of care although the infiltrative nature of MFS mandates wider resection margins than are necessary for UPS. Read More

ACS Med Chem Lett 2022 Jun 13;13(6):885-887. Epub 2022 May 13.

Usona Institute, 277 Granada Drive, San Luis Obispo, California 93401-7337, United States.

Am J Transl Res 2022 15;14(5):2894-2909. Epub 2022 May 15.

University of New South Wales, St. George & Sutherland Clinical School Sydney, NSW 2217, Australia.

Single-agent doxorubicin currently forms part of standard care for patients with sarcomas. However, efficacy is limited by the presence of dose-dependent cardiotoxicity and toxicity to renal, hepatic, and neurological systems. Therefore, there is a pressing need for novel drug regimens which can provide increased efficacy and safety. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):530-535

Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou 450003, China.

To investigate the clinicopathological features, immunophenotypic and molecular genetic characteristics and differential diagnosis of fibrous hamartoma of infancy (FHI). Thirty-three cases of surgically removed FHI were collected from the Department of Pathology, Henan Provincial People's Hospital from October 2011 to December 2020, the clinical and pathologic data with follow-up were collected and analyzed. Next-generation sequencing (NGS) and quantitative real time polymerase chain reaction (q-PCR) were used to study the molecular genetics. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):518-523

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the clinicopathological features, immunophenotype and molecular genetic characteristics of malignant solitary fibrous tumor (MSFT). Seven cases of MSFT were collected from the First Affiliated Hospital of Zhengzhou University from July 2018 to December 2020. Immunohistochemistry, RNA-based NGS and DNA-based NGS were performed. Read More

BMC Cancer 2022 Jun 7;22(1):625. Epub 2022 Jun 7.

Sylvester Comprehensive Cancer Center at University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Tropomyosin receptor kinase (TRK) fusion proteins resulting from neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare primary oncogenic drivers in a wide array of tumors. Larotrectinib is a first-in-class, highly selective, central nervous system-active TRK inhibitor approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), and over 40 countries for the treatment of TRK fusion solid tumors in adult and pediatric patients. Due to the rarity of TRK fusion cancer, larotrectinib was granted accelerated approval based on a relatively small number of patients enrolled in three early phase trials. Read More

Genes Chromosomes Cancer 2022 Jun 7. Epub 2022 Jun 7.

de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

Introduction: The ETV6::NTRK3 fusion is the most common gene alteration in infantile fibrosarcoma, a soft tissue tumor affecting patients under two years of age. Less frequently, these tumors harbor fusions of genes encoding other kinases, such as BRAF, which activates MEK in the mitogen-activated protein kinase pathway. The identification and characterization of these oncogenes are crucial to facilitate diagnosis, validate new treatments, and better understand the pathophysiology of these neoplasms. Read More

Future Med Chem 2022 Jun 7;14(12):881-897. Epub 2022 Jun 7.

Department of Chemistry, Laboratory of Organic Synthesis & Physico-Molecular Chemistry, Faculty of Sciences Semlalia, BP 2390, Marrakesh, 40001, Morocco.

A series of 1,3,4-thiadiazole himachalene hybrids were prepared from the treatment of a himachalen-4-one thiosemicarbazone derivative with N-aryl-C-ethoxycarbonyl-nitrilimines and diarylnitrilimines via a 1,3-dipolar cycloaddition reaction. The structures were confirmed by NMR, IR and high-resolution mass spectroscopy (HRMS). The newly synthesized hybrid compounds were tested for their antitumor activities against a panel of cancer cell lines including fibrosarcoma (HT-1080), lung carcinoma (A-549) and breast carcinoma (MCF-7 and MDA-MB-231). Read More

Front Oncol 2022 20;12:839816. Epub 2022 May 20.

Department of Dermatology, Saarland University Medical Center, Homburg, Germany.

In melanoma and other malignancies, low vitamin D status is associated with increased risk and poor prognosis. However, there are limited data of the impact of 25(OH)D serum concentration (s.c. Read More

Mol Plant 2022 Jun 6. Epub 2022 Jun 6.

State Key Laboratory of Plant Physiology and Biochemistry, college of Biological Sciences, China Agricultural University, Beijing, 100193, China; School of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 100193, China. Electronic address:

Plants adapt to their ever-changing environment via both positive and negative signals induced by environmental stimuli. Drought stress, for instance, induces the accumulation of the plant hormone abscisic acid (ABA), triggering ABA signaling transduction. However, the molecular mechanisms for switching between plant growth promotion and response to stress are still poorly understood. Read More

Chem Biodivers 2022 Jun 4. Epub 2022 Jun 4.

Université de reims champagne -ardenne, pharmacie, 51 rue Cognacq-Jay 51096 REIMS Cedex, Lille, FRANCE.

A new series of analogs-2-imino-4-thiazolidinone hybrid derivatives were synthesized by treatment of limonaketone-thiosemicarbazone derivatives with ethyl bromoacetate and dimethyl acetylene dicarboxylate (DMAD) as the cyclizing reagents. The new derivatives were characterized by HRMS, 1 H NMR and 13 C NMR spectroscopy techniques and one of them is characterized by single crystal X-ray diffraction. The newly synthesized products were biologically evaluated in vitro for their cytotoxic activity against three cancer cell lines including fibrosarcoma (HT-1080), lung carcinoma (A549), and breast carcinoma (MCF-7). Read More

Iran J Basic Med Sci 2022 Apr;25(4):483-488

College of Pharmacy, Xinxiang Medical University, Xinxiang, China.

Objectives: Epigallocatechin-3-gallate (EGCG) has a good therapeutic effect on type 2 diabetes mellitus (T2DM). This work was designed to explore EGCG's effectiveness in insulin resistance (IR) and pancreas islet β-cell function in a rat model of T2DM.

Materials And Methods: Eight-week-old male Sprague Dawley rats were randomly divided into 6 groups, including the Control (normal diet), Diabetes (high-sucrose high-fat [HSHF] diet combined with tail vein injection of streptozotocin [STZ] for T2DM induction) and Treatment Diabetic rats which were treated with metformin [500 mg/kg/d] or EGCG [25, 50 or 100 mg/kg/d] intragastric administration for 10 weeks. Read More

Colloids Surf B Biointerfaces 2022 Aug 18;216:112580. Epub 2022 May 18.

Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India; Centre for Environmental Sciences and Engineering, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India; Centre for Nanosciences, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India; The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, UP 208016, India. Electronic address:

Tissue plasminogen activators induce enzymatic activation of plasminogen to plasmin that cleaves fibrin strands in blood clots. In the present study, extracellular vesicles such as exosomes from fibrosarcoma cell line HT1080 were utilized as clot-busting agents. These exosomes were being used for clot lysis of whole blood which showed 28% lysis within 10 h, which was comparable to that of the streptokinase (commercial plasmin activator) with no significant difference. Read More

J Cancer Res Ther 2022 Apr;18(2):476-481

Department of Radiology, Qilu Hospital of Shandong University (Qingdao), Qingdao, China.

Aims: The study highlights diffusion-weighted imaging (DWI) and dynamic enhancement features of DFSP and characterizes unenhanced and enhanced computed tomography (CT) and magnetic resonance imaging (MRI) scans.

Settings And Design: Image findings and clinical histories of 23 patients with DFSP were reviewed. Nine patients underwent CT before and after intravenous administration of contrast material. Read More

J Cardiothorac Surg 2022 May 31;17(1):134. Epub 2022 May 31.

Department of Radiology, Affiliated Hospital of Shaoxing University (The Shaoxing Municipal Hospital), Shaoxing, 312000, Zhejiang Province, China.

Background: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal tumor that arises at various sites and typically originates from the pleura. Most patients with SFTPs are asymptomatic, unless the tumor is large. Approximately 20% of SFTP cases are malignant. Read More

Medicina (B Aires) 2022 ;82(3):441-444

División Ciencias de la Salud, Universidad del Norte, Barranquilla, Colombia.

Gynecological sarcomas are rare and their location in the vulva and vagina has an incidence of 5% of all malignant neoplasms in the female genital tract. We present the case of a 54-year-old patient with a diagnosis of dermatofibrosarcoma protuberans in the vulva, an infrequent pathology with less than 60 cases reported worldwide in this anatomical location. Clinically, it is locally aggressive, due to the proliferation of spindle cells with pleomorphism and frequent mitotic figures infiltrating the reticular dermis and subcutaneous cellular tissue, giving rise to variable size tumors with high local recurrence rates. Read More

Diagn Pathol 2022 May 30;17(1):48. Epub 2022 May 30.

Department of Pathological Anatomy, FMPM-UCA-CHU Mohamed VI, 40000, Marrakech, Morocco.

Introduction: Malignant schwannoma is a malignant tumor of differentiation of Schwann cells or perineural cells.

Observation: The patient was a 74-year-old woman with no particular pathological history. She presented swallowing difficulty of solids and odynophagia, evolving for 1 year. Read More

J Coll Physicians Surg Pak 2022 Apr;32(4):S24-S27

Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.

   The occurrence of primary malignant peripheral neurilemmoma in the female cervix without neurofibromatosis type 1 is extremely rare. We, herein, report a case of a 46-year woman with malignant peripheral nerve sheath tumor (MPNST) involving the cervix. The patient was admitted to the hospital because of irregular vaginal bleeding. Read More

Gels 2022 Apr 21;8(5). Epub 2022 Apr 21.

Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester M13 9PT, UK.

Hydrogel biomaterials mimic the natural extracellular matrix through their nanofibrous ultrastructure and composition and provide an appropriate environment for cell-matrix and cell-cell interactions within their polymeric network. Hydrogels can be modified with different proteins, cytokines, or cell-adhesion motifs to control cell behavior and cell differentiation. Collagens are desirable and versatile proteins for hydrogel modification due to their abundance in the vertebrate extracellular matrix and their interactions with cell-surface receptors. Read More

JCO Precis Oncol 2022 05;6:e2100283

Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Berlin, Berlin, Germany.

Genes Chromosomes Cancer 2022 May 20. Epub 2022 May 20.

Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.

In this study, we present two extra-renal pediatric spindle cell neoplasms with epidermal growth factor receptor (EGFR) internal tandem duplications (ITD). Histologically, these tumors demonstrated the same histologic features seen in other tyrosine kinase-altered spindle cell neoplasms, with one case showing abundant adipose tissue with cellular fibrous septae resembling lipofibromatosis and the other case showing fascicles of spindled cells resembling infantile fibrosarcoma. There was variable expression of CD34, S100, and SMA, and all cases were negative for panTRK. Read More

J Radiol Case Rep 2022 Jan 1;16(1):1-13. Epub 2022 Jan 1.

Department of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, WV, USA.

We present a case of a 58-year-old woman who had a painful right thigh mass for a few months. A transthoracic echocardiogram revealed no evidence of an intracardiac mass. She had a whole-body positron emission tomography/computed tomography scan two months later that revealed masses in her right lower extremity and a mass in her right ventricle that had not been initially reported. Read More

Cancer Sci 2022 May 17. Epub 2022 May 17.

Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.

BRAF mutations are frequently observed in melanoma and hairy-cell leukemia. Currently approved rapidly accelerated fibrosarcoma (RAF) kinase inhibitors targeting oncogenic BRAF V600 mutations have shown remarkable efficacy in the clinic, but their therapeutic benefits are occasionally hampered by acquired resistance due to RAF dimerization-dependent reactivation of the downstream MAPK pathway, which is known as paradoxical activation. There is also a concern that paradoxical activation of the MAPK pathway may trigger secondary cancer progression. Read More

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):364-365

Nishtar Medical University and Hospital, Multan.

Dermatofibrosarcoma protuberans is a rare cutaneous malignancy. Usual sites of origin are trunk and extremities. Aetiology of the condition is not well understood but a genetic basis is explained as a reciprocal translocation t (17l;22) (q22; q13). Read More

Front Vet Sci 2022 28;9:869017. Epub 2022 Apr 28.

Clinic for Swine, Small Ruminants, Forensic Medicine and Ambulatory Service, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

A 10-year-old female goat was presented to the clinic with lethargy, emaciation, and pale mucous membranes. Laboratory diagnosis revealed severe anemia with regenerative character as well as melena. Blood transfusions were administered, but the animal's condition continued to deteriorate, so it was euthanized. Read More

Plant Physiol 2022 May 14. Epub 2022 May 14.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, China.

Puccinia striiformis f. sp. tritici (Pst) is an important obligate pathogen in wheat (Triticum aestivum L. Read More