17,225 results match your criteria Fibrosarcoma


Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 15.

Burke Neurological Institute, White Plains, New York 10605.

Ferroptotic death is a mechanism for tumor suppression by pharmacological inhibitors that target the X transporter (cystine/glutamate antiporter) in a host of non-CNS and CNS tumors. Inhibition of this transporter leads to reduction of cystine uptake, cyst(e)ine deprivation, subsequent depletion of the versatile antioxidant glutathione, and reactive lipid species-dependent death. Accordingly, pharmacological inhibitors of the X transporter can also induce neuronal cell death raising concerns about toxicity in the CNS and PNS if these agents are used for chemotherapy. Read More

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http://eneuro.org/lookup/doi/10.1523/ENEURO.0263-18.2019
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http://dx.doi.org/10.1523/ENEURO.0263-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378329PMC
February 2019
1 Read

Vascular-endothelial response to IDH1 mutant fibrosarcoma secretome and metabolite: implications on cancer microenvironment.

Am J Cancer Res 2019 1;9(1):122-133. Epub 2019 Jan 1.

Laboratory of Cell Biology, Bergen County Academies 200 Hackensack Ave, Hackensack, NJ 07601, USA.

Isocitrate dehydrogenases (IDHs) are enzymes involved in the production of α-ketoglutarate (αkg) in normal cellular metabolism. Cells with IDH mutations reduce αkg to 2-hydroxyglutarate (2HG), an oncometabolite, and 2HG directly transforms normal cells to malignant cells through histone demethylation and epigenetic dysregulation. However, whether IDH mutations affect cancer stromal cells is elusive, and little is known whether 2HG may impact the tumor microenvironment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356916PMC
January 2019
1 Read

Evaluation of MMP Inhibitors Isolated from Fructus.

Molecules 2019 Feb 8;24(3). Epub 2019 Feb 8.

Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea.

The current study investigated the ability of two secoiridoids, GL-3 () and oleonuezhenide (), isolated from the fruits of to inhibit MMP-2 and -9 activity in phorbol 12-myristate 13-acetate (PMA)-induced HT-1080 human fibrosarcoma cells. Both compound and were able to exert lowered gelatin digestion activity for MMP-2 and -9 tested by gelatin zymography via suppressing the release of MMPs to culture medium according to ELISA results. Treatment with compounds was also able to suppress the expression of both mRNA and protein levels of MMP-2 and -9. Read More

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http://dx.doi.org/10.3390/molecules24030604DOI Listing
February 2019

Utilizing photosensitizing and radiosensitizing properties of TiO-based mitoxantrone imprinted nanopolymer in killing fibrosarcoma and melanoma cells.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Some materials such as TiO display a luminescence property when exposed to X-ray radiation. Therefore, a proper photosensitizer can induce photodynamic effects by absorbing the emitted photons from these materials during radiotherapy. In this way, the problem of limited photo- penetration depth in photodynamic therapy is resolved. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.006DOI Listing
February 2019
2.014 Impact Factor

A case of congenital infantile fibrosarcoma in a newborn.

Wiad Lek 2018 ;71(9):1844-1848

Department Of Pediatric №1, Vinnytsya National Pirogov Memorial Medical University, Vinnytsya, Ukraine.

Infantile fibrosarcoma is a malignant tumor, which is most common in infants, preferentially localized in the lower limbs. An important prognostic factor of the disease is early diagnostics, both clinical and instrumental. The operative treatment of infantile fibrosarcoma is a leading treatment method. Read More

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January 2018

Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis.

Nanomedicine (Lond) 2019 Jan 6;14(2):169-182. Epub 2018 Dec 6.

Mallinckrodt Institute of Radiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.

Aim: CaCO nanoparticles (nano-CaCO) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO to noninvasively monitor pH modulation and subsequent tumor response.

Materials & Methods: We synthesized ferromagnetic core coated with CaCO (magnetite CaCO). Read More

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http://dx.doi.org/10.2217/nnm-2018-0302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369564PMC
January 2019

Long-term live cells observation of internalized fluorescent Fe@C nanoparticles in constant magnetic field.

J Nanobiotechnology 2019 Feb 6;17(1):27. Epub 2019 Feb 6.

Faculté de Médecine, Université François Rabelais, 37032, Tours, France.

Background: Theranostics application of superparamagnetic nanoparticles based on magnetite and maghemite is impeded by their toxicity. The use of additional protective shells significantly reduced the magnetic properties of the nanoparticles. Therefore, iron carbides and pure iron nanoparticles coated with multiple layers of onion-like carbon sheath seem to be optimal for biomedicine. Read More

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http://dx.doi.org/10.1186/s12951-019-0463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364403PMC
February 2019
2 Reads

Methioninase Gene Therapy.

Methods Mol Biol 2019 ;1866:173-197

AntiCancer, Inc., San Diego, CA, USA.

Recombinant methioninase (rMETase) derived from Pseudomonas putida targets the elevated methionine (MET) requirement of cancer cells (methionine dependence) and has shown efficacy against a variety of cancer types in mouse models. To enhance the efficacy of rMETase, we constructed the pLGFP-METSN retrovirus encoding the P. putida methioninase (METase) gene fused with the green fluorescent protein (GFP) gene. Read More

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http://dx.doi.org/10.1007/978-1-4939-8796-2_14DOI Listing
January 2019
1 Read

Refractory and metastatic infantile fibrosarcoma harboring fusion shows complete and durable response to crizotinib.

Cold Spring Harb Mol Case Stud 2019 Feb 1;5(1). Epub 2019 Feb 1.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Infantile fibrosarcoma (IFS) is a rare soft-tissue sarcoma, which classically presents as an aggressive and rapidly enlarging tumor over the distal extremities of children in their first year of life. The presence of and gene rearrangement is characteristic of IFS, which can be detected on routine fluorescence in situ hybridization (FISH) testing. Patients with IFS typically respond well to surgical resection and chemotherapy and have an overall survival of ∼90%. Read More

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http://dx.doi.org/10.1101/mcs.a003376DOI Listing
February 2019

Durotaxis by Human Cancer Cells.

Biophys J 2019 Feb 12;116(4):670-683. Epub 2019 Jan 12.

Cell Biology Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland. Electronic address:

Durotaxis is a type of directed cell migration in which cells respond to a gradient of extracellular stiffness. Using automated tracking of positional data for large sample sizes of single migrating cells, we investigated 1) whether cancer cells can undergo durotaxis; 2) whether cell durotactic efficiency varies depending on the regional compliance of stiffness gradients; 3) whether a specific cell migration parameter such as speed or time of migration correlates with durotaxis; and 4) whether Arp2/3, previously implicated in leading edge dynamics and migration, contributes to cancer cell durotaxis. Although durotaxis has been characterized primarily in nonmalignant mesenchymal cells, little is known about its role in cancer cell migration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063495193002
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http://dx.doi.org/10.1016/j.bpj.2019.01.009DOI Listing
February 2019
2 Reads

Update on Lipomatous Tumors with Emphasis on Emerging Entities, Unusual Anatomic Sites, and Variant Histologic Patterns.

Surg Pathol Clin 2019 Mar;12(1):21-33

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO, USA. Electronic address:

This article reviews the histologic patterns of spindle cell/pleomorphic lipoma, well-differentiated liposarcoma, and dedifferentiated liposarcoma in the context of both usual and atypical anatomic presentation. The utility of molecular and immunohistochemical diagnostic modalities to distinguish these entities is described. In addition, more recently described and controversial entities, including atypical spindle cell lipomatous tumor and anisometric cell lipoma, are discussed. Read More

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http://dx.doi.org/10.1016/j.path.2018.11.001DOI Listing
March 2019
1 Read

Design, synthesis, and cytotoxic activity of 3-aryl-N-hydroxy-2(sulfonamido)propanamides in HepG2, HT-1080, KB, and MCF-7 cells.

Chem Biodivers 2019 Feb 1. Epub 2019 Feb 1.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China, CHINA.

A new series of compounds containing (sulfonamido) propanamide (6a1-13, 6b1-15, 7c1-5, 6d1-5, 6e1-6) was designed and synthesized. All the synthesized compounds were characterized by NMR and mass spectrometry. The target compounds were evaluated for their in vitro cytotoxic activity against hepatocellular carcinoma (HepG2), fibrosarcoma (HT-1080), mouth epidermal carcinoma (KB), and breast adenocarcinoma (MCF-7) cells with the sulforhodamine B (SRB) assay, with gemcitabine and mitomycin C as positive controls. Read More

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http://dx.doi.org/10.1002/cbdv.201800646DOI Listing
February 2019
1 Read

Role of postoperative radiotherapy in dermatofibrosarcoma protuberans: a propensity score-matched analysis.

Radiat Oncol 2019 Jan 29;14(1):20. Epub 2019 Jan 29.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, 350014, China.

Objective: This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS).

Methods: A total of 184 patients with DFSP were analyzed from 2000 to 2016. The regression model was used to examine the prognostic factors for DFS. Read More

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http://dx.doi.org/10.1186/s13014-019-1226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350344PMC
January 2019
1 Read

Odontogenic tumors: A 35-year retrospective study of 250 cases in an Indian (Maharashtra) teaching institute.

Indian J Cancer 2018 Jul-Sep;55(3):265-272

Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India.

Context: This retrospective study was planned to ascertain the relative frequency of odontogenic tumors (OTs) in an Indian population in the light of the latest World Health Organization (WHO) classification.

Aim: To compare data with various reports from other parts of the world.

Study Design: Retrospective study. Read More

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http://dx.doi.org/10.4103/ijc.IJC_145_18DOI Listing
January 2019

Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Dec 31. Epub 2018 Dec 31.

Molecular Pathology Area, School of Dentistry, Universidad de La Republica (UDELAR), Montevideo, Uruguay.

Objectives: The aim of this study was to analyze the immunohistochemical expression of fatty acid synthase (FASN) and cyclooxygenase-2 (COX-2) in tooth germ (TG), ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF), and ameloblastic fibrosarcoma (AFS).

Study Design: Immunohistochemistry for FASN and COX-2 was performed in 10 TG, 44 AM, 10 AC, 9 AF, and 5 AFS specimens. The results were analyzed by using the immunoreactive score (IRS) and Kruskal-Wallis test followed by Dunn's post-test. Read More

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http://dx.doi.org/10.1016/j.oooo.2018.12.020DOI Listing
December 2018
1 Read

Improved Anticancer Effect of Recombinant Protein izTRAIL Combined with Sorafenib and Peptide iRGD.

Int J Mol Sci 2019 Jan 27;20(3). Epub 2019 Jan 27.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.

One of the main problems in oncology is the development of drugs that cause the death of cancer cells without damaging normal cells. Another key problem to be solved is to suppress the drug resistance of cancer cells. The third important issue is to provide effective penetration of drug molecules to cancer cells. Read More

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http://dx.doi.org/10.3390/ijms20030525DOI Listing
January 2019

Density-dependent ERK MAPK expression regulates MMP-9 and influences growth.

Mol Cell Biochem 2019 Jan 28. Epub 2019 Jan 28.

Biology Department, Monmouth University, 400 Cedar Avenue, West Long Branch, NJ, 07764, USA.

Previous work has shown that expression of the extracellular signal-regulated kinase (ERK) is decreased by high density in normal fibroblast cells, and this was correlated with increased expression of mitogen-activated protein kinase phosphatases. Because of these differences in ERK regulation upon contact inhibition, it is likely that other cellular responses may be influenced by the attainment of a contact-inhibited state. Expression of matrix metalloproteinase-9 and cadherin cleavage were both found to be decreased upon reaching high culture density. Read More

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http://link.springer.com/10.1007/s11010-019-03496-w
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http://dx.doi.org/10.1007/s11010-019-03496-wDOI Listing
January 2019
4 Reads

A large calvarial bone defect in a child: osteointegration of an implant.

World Neurosurg 2019 Jan 23. Epub 2019 Jan 23.

Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; PO Box 23, 90029 OYS, Finland; Medical Research Center Oulu, and PEDEGO Research Unit, University of Oulu, Oulu, Finland.

Background: This is an original report describing the long-term follow-up outcome of a cranioplasty. A large calvarial bone defect of a child was reconstructed with a bioactive and biostable non-metallic implant.

Case Description: This is a case study of a young child with an infantile fibrosarcoma of occipital bone. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.028DOI Listing
January 2019
4 Reads

Piceatannol-3-O-β-D-glucopyranoside (PG) exhibits in vitro anti-metastatic and anti-angiogenic activities in HT1080 malignant fibrosarcoma cells.

Phytomedicine 2018 Dec 11;57:95-104. Epub 2018 Dec 11.

Korean-Medicine Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Republic of Korea. Electronic address:

Background: Several components isolated from rhubarb, the root of Rheum undulatum L., including emodin, rhein, rhaponticin, and piceatannol, have been reported to induce cell death and inhibit metastasis in various types of cancer. Recently, piceatannol-3-O-β-D-glucopyranoside (PG) isolated from rhubarb was demonstrated to improve vascular dysfunction by inhibiting arginase activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183060
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http://dx.doi.org/10.1016/j.phymed.2018.12.017DOI Listing
December 2018
5 Reads

A novel MAF missense mutation leads to congenital nuclear cataract by impacting the transactivation of crystallin and noncrystallin genes.

Gene 2019 Apr 17;692:113-118. Epub 2019 Jan 17.

McKusick-Zhang Center for Genetic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address:

The transcription factor v-maf avain musculoaponeurotic fibrosarcoma oncogene homolog (MAF) plays an important role in lens development. It contains a unique extended homology region (EHR) in the DNA binding domain. MAF mutations are associated with phenotypically distinct forms of congenital cataract and show different effects on the transactivation of target genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193004
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http://dx.doi.org/10.1016/j.gene.2019.01.011DOI Listing
April 2019
5 Reads

Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells.

Cell Stress Chaperones 2019 Jan 18. Epub 2019 Jan 18.

Laboratory of Cell Culture and Cell Engineering, Institute of Cell Biophysics, Russian Academy of Sciences, Moscow region, Institutskaya St. 3, Pushchino, 142290, Russia.

The extracellular heat shock protein 90 (Hsp90) is known to participate in cell migration and invasion. Recently, we have shown that cell surface heparan sulfate proteoglycans (HSPGs) are involved in the binding and anchoring of extracellular Hsp90 to the plasma membrane, but the biological relevance of this finding was unclear. Here, we demonstrated that the digestion of heparan sulfate (HS) moieties of HSPGs with a heparinase I/III blend and the metabolic inhibition of the sulfation of HS chains by sodium chlorate considerably impair the migration and invasion of human glioblastoma A-172 and fibrosarcoma HT1080 cells stimulated by extracellular native Hsp90. Read More

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http://link.springer.com/10.1007/s12192-018-0955-5
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http://dx.doi.org/10.1007/s12192-018-0955-5DOI Listing
January 2019
4 Reads

Selective Synthesis of (+)-Dysoline.

Org Lett 2019 Feb 17;21(3):648-651. Epub 2019 Jan 17.

Department of Biochemistry, Division of Chemistry , UT Southwestern Medical Center , 5323 Harry Hines Blvd. , Dallas , Texas 75390-0938 , United States.

Dysoline, a novel chromone alkaloid isolated from Dysoxylum binectariferum, was reported to have selective cytotoxicity for HT1080 fibrosarcoma cells (IC of 0.21 μM). Given the scarcity of natural material, a concise synthesis of (+)-dysoline was developed, allowing for further biological evaluation. Read More

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http://dx.doi.org/10.1021/acs.orglett.8b03777DOI Listing
February 2019

[Total femoral replacement for treating femur malignant tumor].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Jan;33(1):18-22

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To investigate the procedure and effectiveness of total femoral replacement for treating femur malignant tumor.

Methods: The clinical data of 9 patients with femoral malignant tumors who underwent total femoral replacement between July 2013 and March 2017 were retrospectively analyzed. There were 5 males and 4 females, aged 16-75 years with an average of 44. Read More

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http://dx.doi.org/10.7507/1002-1892.201807052DOI Listing
January 2019
1 Read

[Intrathecal injection of AG-490 reduces bone-cancer-induced spinal cord astrocyte reaction and thermal hyperalgesia in a mouse model].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1182-1187

Department of Anesthesiology, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210008, China.

Objective: To investigate the role of spinal interleukin-6-Janus kinase 2 (IL-6-JAK2) signaling transduction pathway in regulating astrocytes activation during the maintenance of bone cancer pain (BCP).
 Methods: NCTC 2472 fibrosarcoma cells were injected into the femur marrow cavity in C3H/HeNCrlVr male mice to establish BCP model and they were replaced by the equal volume of α-MEM in the sham model. The paw withdrawal latency (PWL) was measured after inoculation of tumor cells. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.003DOI Listing
November 2018
3 Reads

Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy.

Molecules 2019 Jan 11;24(2). Epub 2019 Jan 11.

Department of Biological Sciences, Xian Jiaotong Liverpool University, 111 Ren Ai Road, Suzhou 215123, China.

Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive molecules to allow metastasis and cell proliferation. The activity of MT1-MMP is modulated by the endogenous inhibitors, Tissue Inhibitor of Metalloproteinases (TIMPs). In this study, we describe a novel strategy that would enable a "designer" TIMP-1 tailored specifically for MT1-MMP inhibition (V4A/P6V/T98L; 1. Read More

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http://www.mdpi.com/1420-3049/24/2/255
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http://dx.doi.org/10.3390/molecules24020255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359047PMC
January 2019
5 Reads
2.416 Impact Factor

Neurotrophic tropomyosin or tyrosine receptor kinase (NTRK) genes.

Authors:
Runjan Chetty

J Clin Pathol 2019 Mar 13;72(3):187-190. Epub 2019 Jan 13.

Department of Anatomical Pathology, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada

The neurotrophic tropomyosin or tyrosine receptor kinase (NTRK) genes (1-3) are proto-oncogenes that when activated are encountered in a wide array of tumours. The recent advent of very specific and selective inhibitors of their gene fusions makes the NRTK gene fusions actionable. NRTK gene fusions are very characteristic of specific tumours: salivary mammary analogue secretory carcinoma, breast secretory carcinoma, infantile fibrosarcoma and congenital mesoblastic nephroma. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205672DOI Listing

New fusion sarcomas histopathology and clinical significance of selected entities.

Hum Pathol 2019 Jan 8. Epub 2019 Jan 8.

Laboratory of Pathology, National Cancer Institute, Bethesda, MD.

Many sarcomas contain gene fusions that can be pathogenetic mechanisms and diagnostic markers. In this article we review selected fusion sarcomas and techniques for their detection. CIC-DUX4 fusion sarcoma is a round-cell tumor now considered an entity separate from Ewing sarcoma with a more aggressive clinical course, occurrence in older age, and predilection to soft tissues. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.006DOI Listing
January 2019
10 Reads

Nivolumab to pembrolizumab switch induced a durable melanoma response: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e13804

Department of Veteran Affairs, Bruce W. Carter VA Medical Center, Miami, FL.

Rationale: While checkpoint inhibitors have revolutionized the treatment of melanoma, it is not known whether switching from one monoclonal antibody drug to another one would be justified in the case of a treatment failure. Herein, we report a case illustrating a durable response to pembrolizumab after a failure with nivolumab.

Patient Concerns: A 76-year-old white male noticed an enlarging papular lesion on his neck. Read More

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http://dx.doi.org/10.1097/MD.0000000000013804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336603PMC
January 2019
12 Reads
5.723 Impact Factor

Sports activity after soft tissue sarcoma of the lower extremity.

Disabil Rehabil 2019 Jan 8:1-6. Epub 2019 Jan 8.

a Department of Orthopaedic Surgery , Medical University of Vienna, Vienna General Hospital , Vienna , Austria.

Introduction: The aim of this case series was to assess sports activity levels in long-term survivors of soft-tissue sarcomas after multimodal treatment including limb salvaging surgical resection and radio-chemotherapy.

Methods: Thirty-two patients (17 f/15 m) with a mean age of 29 (range 10-44) years at the time of diagnosis and a mean follow-up time of 9 (range 3-21) years following sarcoma were included. Ten patients had been diagnosed with liposarcoma, seven with synovial sarcoma, four with fibrosarcoma, three with undifferentiated pleomorphic sarcomas and the remaining eight patients with different soft-tissue sarcoma entities. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2018.1
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http://dx.doi.org/10.1080/09638288.2018.1520929DOI Listing
January 2019
6 Reads

Fibroblastic and myofibroblastic tumors of children: new genetic entities and new ancillary testing.

Authors:
David M Parham

F1000Res 2018 20;7. Epub 2018 Dec 20.

Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Fibroblastic and myofibroblastic tumors comprise a morphologically diverse and biologically variable group of neoplasms that affect a wide age range. Specific entities tend to occur most frequently in infants and young children. Recent years have witnessed a proliferation of information concerning the unique biology of these tumors. Read More

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https://f1000research.com/articles/7-1963/v1
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http://dx.doi.org/10.12688/f1000research.16236.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305242PMC
December 2018
2 Reads

Drug repurposing: mebendazole as effective antitumor agent. Are we seeing the whole story?

J BUON 2018 Nov-Dec;23(6):1904-1911

Medical Faculty Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia.

Purpose: To examine the antitumor effects of Mebendazole (MZ) in a model of experimental fibrosarcoma induced by inoculation of BHK-21/C13 cells in Syrian golden hamster.

Methods: Hamsters were inoculated with a suspension of BHK cells by subcutaneous injection and randomly divided into 5 experimental and 2 control groups. Treatment started on the 10th day after inoculation, when the tumor grew to a diameter of 5mm. Read More

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January 2019
3 Reads

α-Ketoglutaric Acid-Modified Carbonate Apatite Enhances Cellular Uptake and Cytotoxicity of a Raf- Kinase Inhibitor in Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways.

Biomedicines 2019 Jan 3;7(1). Epub 2019 Jan 3.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan,Bandar Sunway, 47500 Subang Jaya, Malaysia.

AZ628 is a hydrophobic Raf-kinase inhibitor (rapidly accelerated fibrosarcoma) currently in clinical trial of various cancer. The physicochemical properties of hydrophobic drugs that affect the drug-particle interactions and cause aggregation of drugs and particles might be the key aspect to impede effective drug delivery. Retaining smaller particle size is the prerequisite to overcome the opsonization and improve cytotoxicity in the targeted region. Read More

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http://www.mdpi.com/2227-9059/7/1/4
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http://dx.doi.org/10.3390/biomedicines7010004DOI Listing
January 2019
1 Read

Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy.

Biosensors (Basel) 2018 Dec 28;9(1). Epub 2018 Dec 28.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas, fibrosarcoma, and other cancers leads to a novel metabolite, D-2-hydroxyglutarate, which is proposed to cause tumorigenesis. The production of this metabolite also causes vulnerabilities in cellular metabolism, such as lowering NADPH levels. To exploit this vulnerability, we treated glioma and fibrosarcoma cells that harbor an IDH1 mutation with an inhibitor of nicotinamide adenine dinucleotide (NAD⁺) salvage pathway, FK866, and observed decreased viability in these cells. Read More

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http://dx.doi.org/10.3390/bios9010005DOI Listing
December 2018
1 Read

Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells.

J Control Release 2019 Feb 26;295:60-73. Epub 2018 Dec 26.

Department of Pharmacology, Pharmacy and Pharmaceutical Technology, CIMUS Research Institute, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address:

Myeloid-Derived Suppressor Cells (MDSCs), immunosuppressive cells that promote tumor growth, represent an attractive target in cancer immunotherapy. However, the clinical success of this strategy is limited by the lack of efficient drug delivery vehicles targeting this cell compartment. The objective of this work was to develop a delivery carrier, multilayer polymer nanocapsules, with the capacity to co-encapsulate two types of immunomodulatory drugs, a chemokine and an RNAi sequence, aimed at reverting MDSC-mediated immunosuppression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183074
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http://dx.doi.org/10.1016/j.jconrel.2018.12.041DOI Listing
February 2019
3 Reads

TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.

J Clin Oncol 2019 Feb 28;37(6):513-524. Epub 2018 Dec 28.

University of Texas Southwestern Medical Center/Children's Health, Dallas, TX.

Chromosomal translocations involving the NTRK1, NTRK2, and NTRK3 genes (TRK fusions), which encode the neurotrophin tyrosine kinase receptors TRKA, TRKB, and TRKC, can result in constitutive activation and aberrant expression of TRK kinase. Certain cancers almost universally harbor TRK fusions, including infantile fibrosarcoma, cellular congenital mesoblastic nephroma, secretory breast cancer, and mammary analog secretory carcinoma of the salivary gland. TRK fusions have also been identified at lower frequencies across a broad range of other pediatric cancers, including undifferentiated sarcomas, gliomas, papillary thyroid cancers, spitzoid neoplasms, inflammatory myofibroblastic tumors, and acute leukemias. Read More

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http://dx.doi.org/10.1200/JCO.18.00573DOI Listing
February 2019
1 Read

Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-κB dependent transcriptional activities.

Food Chem Toxicol 2018 Dec 24;125:1-9. Epub 2018 Dec 24.

College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea. Electronic address:

Coffee is one of the widely sales beverage worldwide and contains numerous phytochemicals that are beneficial to health. Kahweol acetate (KA), a coffee-specific diterpene, exhibits anti-tumoric properties in human tumoric cells. However, the effect of KA on the metastasis and invasion of cancer cells and the underlying mechanisms remain unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183092
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http://dx.doi.org/10.1016/j.fct.2018.12.038DOI Listing
December 2018
5 Reads

Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors.

Am J Surg Pathol 2018 Dec 24. Epub 2018 Dec 24.

Department of Laboratories, Seattle Children's Hospital, Seattle, WA.

Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being increasingly described; however, the histologic and clinical features of these variant NTRK tumors and their relationship to classic infantile fibrosarcoma are not well characterized. A better understanding of the clinicopathologic features of these tumors is necessary, and would aid in both early diagnosis and treatment. Therefore, the aim of this study was to characterize a series of pediatric NTRK-rearranged mesenchymal tumors, including classic ETV6-NTRK3 fused tumors and tumors with variant (non-ETV6) NTRK fusions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001203DOI Listing
December 2018
2 Reads

Congenital infantile fibrosarcoma of the glabella: Nuances of achieving surgical cure without cosmetic or functional deformity.

Int J Pediatr Otorhinolaryngol 2019 Feb 13;117:110-114. Epub 2018 Oct 13.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, UNM School of Medicine, MSC 10 5610, 1 University of New Mexico, Albuquerque, NM, 87131, United States. Electronic address:

Congenital Infantile Fibrosarcoma is a rare neoplasm that typically presents during the first year of life, but uncommonly in the head and neck. We report a six-day old male presenting with an expanding mass of the right glabella associated with visual field obstruction. The patient underwent a two-staged procedure for surgical removal of the tumor due to the initially unclear pathologic diagnosis of the tumor, combined with the desire to close the defect while incurring minimal aesthetic or functional deformity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183053
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http://dx.doi.org/10.1016/j.ijporl.2018.10.020DOI Listing
February 2019
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Primary intracranial fibrosarcomas: a case report and systematic review of literature.

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Primary intracranial fibrosarcoma (PIF) is an exceedingly rare tumor. Only about 50 cases have been reported in the literature. Here, we present a case of a 20-year-old male who presented with a sudden onset headache. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183281
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http://dx.doi.org/10.1016/j.wneu.2018.12.005DOI Listing
December 2018
10 Reads

No, it is not a third breast that grows!

Pan Afr Med J 2018 16;30:213. Epub 2018 Jul 16.

General Practitioner Office Henri IV 45, Boulevard Henri IV, Ambert France.

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http://dx.doi.org/10.11604/pamj.2018.30.213.16402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294974PMC
January 2019

Reverse turnover pedicled latissimus dorsi muscle flap for lower back reconstruction: Two case reports.

Medicine (Baltimore) 2018 Dec;97(51):e13851

Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: Large soft tissue defects on the lower back represent a treatment challenge. Among a variety of reconstructive procedures, the latissimus dorsi (LD) muscle or musculocutaneous flap is one of most frequently used pedicled flaps. However, the pedicled LD flap carries a bulky pivot point and a short arc of rotation. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0013
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http://dx.doi.org/10.1097/MD.0000000000013851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320210PMC
December 2018
13 Reads

[Umbilical fibrous hamartoma of infancy: A case report].

Rev Chil Pediatr 2018 Oct;89(5):655-659

Servicio de Anatomía Patológica, Clínica Santa María, Santiago, Chile.

Introduction: Fibrous hamartoma of infancy (FHI) is a benign, soft tissue tumor that usually oc curs in children and has a characteristic histological morphology.

Objective: To describe a case of congenital FHI with atypical histological and clinical characteristics.

Clinical Case: Full-term male newborn, with no perinatal morbid history was referred to dermatology due to a congenital erythe matous plaque in the umbilical region. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000803DOI Listing
October 2018
11 Reads

Clinical epidemiology and treatment outcomes of spindle cell non-osteogenic bone sarcomas - A nationwide population-based study.

J Bone Oncol 2019 Feb 20;14:002-2. Epub 2018 Nov 20.

Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, P.O. Box 4953, Nydalen, N-0424 Oslo, Norway.

Purpose: To describe epidemiological and clinical characteristics, as well as long-term treatment outcomes of spindle cell non-osteogenic bone sarcomas (SCS), comprising leiomyosarcoma, fibrosarcoma and undifferentiated pleomorphic sarcoma in bone.

Method: We have analysed a nationwide cohort of 104 patients with histologically verified SCS diagnosed between 1975 and 2009, based on registry sources supplemented with clinical records from Norwegian hospitals involved in sarcoma management.

Results: In this unselected cohort, a stable annual incidence for SCS patients of slightly below 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22121374183026
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http://dx.doi.org/10.1016/j.jbo.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290118PMC
February 2019
3 Reads

Recurrence of multiple metastases after surgical removal of a primary malignant solitary fibrous tumor from the main bronchus: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13560

Department of Thoracic Surgery.

Rationale: Limited knowledge is available regarding solitary fibrous tumors (SFTs), about 15% of which are malignant. In particular, the long-term survival of patients with malignant SFTs (mSFTs), the disease course, and the potential for recurrence of second primary tumors or distant metastases are largely undetermined.

Patient Concerns: We report a rare case in which an mSFT was found at the main bronchus of the right lung of a 37-year-old man. Read More

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http://dx.doi.org/10.1097/MD.0000000000013560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320158PMC
December 2018
1 Read

Pediatric head and neck fibrosarcomas: A demographical, treatment, and survival analysis and review of a rare case.

Int J Pediatr Otorhinolaryngol 2019 Jan 2;116:92-96. Epub 2018 Oct 2.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology-Head Neck Surgery/Audiology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine pediatric head and neck fibrosarcoma cases and review the demographics, management, and survival for these patients.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of a head and neck fibrosarcoma using ICD-O-3 head and neck primary sites and histology codes. Patients were included from birth-18 years of age. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.09.031DOI Listing
January 2019
1 Read

Antitumor effect of chondroitin AC lyase (PsPL8A) from Pedobacter saltans on melanoma and fibrosarcoma cell lines by in vitro analysis.

Pharmacol Rep 2019 Feb 25;71(1):167-174. Epub 2018 Oct 25.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India. Electronic address:

Background: PGs are involved in cellular communication and cancer biology. The role of CS in melanoma and fibrosarcoma cell lines was explored by using chondroitin AC lyase (PsPL8A).

Methods: The proliferation of mouse fibroblast L929, human melanoma (SK-Mel 28) and fibrosarcoma (HT-1080) cell lines after treatment with chondroitin AC lyase (PsPL8A) was studied by MTT assay. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.009DOI Listing
February 2019
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A rare case of intracardiac fibrosarcoma with myxoid features inducing venous occlusion in a dog - a case report.

BMC Vet Res 2018 Dec 14;14(1):398. Epub 2018 Dec 14.

Department of Pathology, University of Agricultural Sciences and Veterinary Medicine "Ion Ionescu de la Brad", Iași, Romania.

Background: In both humans and animals, cardiac fibrosarcoma is rare among primary cardiac malignant neoplasia. The overall prevalence of cardiac neoplasia in dogs is low, reported to be between 0.17% and 0. Read More

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http://dx.doi.org/10.1186/s12917-018-1735-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295096PMC
December 2018
5 Reads

Time-resolved ultrastructure of the cortical actin cytoskeleton in dynamic membrane blebs.

J Cell Biol 2019 Feb 12;218(2):445-454. Epub 2018 Dec 12.

Laboratory of Mechanisms of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Moscow, Russia

Membrane blebbing accompanies various cellular processes, including cytokinesis, apoptosis, and cell migration, especially invasive migration of cancer cells. Blebs are extruded by intracellular pressure and are initially cytoskeleton-free, but they subsequently assemble the cytoskeleton, which can drive bleb retraction. Despite increasing appreciation of physiological significance of blebbing, the molecular and, especially, structural mechanisms controlling bleb dynamics are incompletely understood. Read More

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http://dx.doi.org/10.1083/jcb.201806075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363452PMC
February 2019
1 Read