17,679 results match your criteria Fibrosarcoma


Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma.

Hepatol Commun 2020 Jun 16;4(6):834-851. Epub 2020 Apr 16.

Department of Internal Medicine III University Hospital RWTH Aachen Aachen Germany.

Targeted inhibition of the c-Jun N-terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)-related tumorigenesis. However, the cell-type-specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate the relevance of JNK1 and JNK2 function in hepatocytes in two different models of experimental carcinogenesis, the dethylnitrosamine (DEN) model and in nuclear factor kappa B essential modulator (NEMO) mice, focusing on liver damage, cell death, compensatory proliferation, fibrogenesis, and tumor development. Read More

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http://dx.doi.org/10.1002/hep4.1495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262317PMC

Recurrent EGFR alterations in NTRK3 fusion negative congenital mesoblastic nephroma.

Pract Lab Med 2020 Aug 16;21:e00164. Epub 2020 May 16.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Objectives: To identify oncogenic driver mutations in congenital mesoblastic nephroma (CMN) cases lacking - fusion and discuss their diagnostic value.

Design: The institutional pathology database was queried for cases with a morphologic diagnosis of CMN. Cases positive for rearrangement or with unavailable blocks were excluded. Read More

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http://dx.doi.org/10.1016/j.plabm.2020.e00164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260589PMC

Biocompatibility, biodistribution and efficacy of magnetic nanohydrogels in inhibiting growth of tumors in experimental mice models.

Biomater Sci 2014 Mar 20;2(3):370-380. Epub 2013 Nov 20.

Department of Metallurgical Engineering & Materials Science, Indian Institute of Technology Bombay, Mumbai, 400076, India.

We report in vivo evaluation of a thermo-responsive poly(N-isopropylacrylamide)-chitosan based magnetic nanohydrogel (MNHG) incorporated with FeO nanoparticles (NPs) in mice models with expandible scope for use in localized delivery of chemotherapeutics. Biocompatibility and biodistribution of the MNHG are studied in normal Swiss mice while efficacy in tumor growth inhibition is studied in a subcutaneous fibrosarcoma tumor. The ex vivo time-dependent pattern of accumulated MNHG into vital organs; lung, liver, spleen, kidney and brain collected at 1 h, 48 h, 7 d and 14 d post intravenous administration are investigated using both a vibrating sample magnetometer (VSM) and inductively coupled plasma-atomic emission spectroscopy (ICP-AES) method. Read More

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http://dx.doi.org/10.1039/c3bm60225gDOI Listing

Diagnostic Yield of Micro-Computed Tomography (micro-CT) Versus Histopathology of a Canine Oral Fibrosarcoma.

J Vet Dent 2020 Jun 2:898756420926519. Epub 2020 Jun 2.

Dentistry and Oral Surgery Service, Section of Surgery, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Micro-computed tomography (micro-CT) imaging currently gains increased interest in human as well as veterinary medicine. The ability to image 3-dimensional (3D) biopsy specimens nondestructively down to 1 µm spatial resolution makes it a promising tool for microscopic tissue evaluation in addition to histopathology. Visualizing tumor margins and calculating tumor load on 3D reconstructions may also enhance oncological therapies. Read More

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http://dx.doi.org/10.1177/0898756420926519DOI Listing

[The regulatory mechanism of Raf/MEK/ERK pathway on the rat cardiac hypertrophy induced by transverse aortic constriction].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Jan;36(1):33-38

Laboratory Animal Research Center/Institute of Comparative Medicine Zhejiang Chinese Medical University, Hangzhou 310053.

Objective: To investigate the mRNA, protein expression levels and the phosphorylation levels of key factors in rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular regulated protein kinases (Raf/MEK/ERK) pathway, and to clarify the regulatory function of Raf/MEK/ERK pathway in myocardial hypertrophy.

Methods: Twenty SD rats were divided into sham-operated group and model group. The myocardial hypertrophy model was established by transverse aortic constriction (TAC). Read More

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http://dx.doi.org/10.12047/j.cjap.5834.2020.007DOI Listing
January 2020

Spatially heterogeneous dynamics of cells in a growing tumor spheroid: comparison between theory and experiments.

Soft Matter 2020 May 28. Epub 2020 May 28.

Department of Chemistry, University of Texas at Austin, Austin, TX 78712, USA.

Collective cell movement, characterized by multiple cells that are in contact for substantial periods of time and undergo correlated motion, plays a central role in cancer and embryogenesis. Recent imaging experiments have provided time-dependent traces of individual cells, thus providing an unprecedented picture of tumor spheroid growth. By using simulations of a minimal cell model, we analyze the experimental data that map the movement of cells in a fibrosarcoma tumor spheroid embedded in a collagen matrix. Read More

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http://dx.doi.org/10.1039/c9sm02277eDOI Listing

Pan-sarcoma genomic analysis of KMT2A rearrangements reveals distinct subtypes defined by YAP1-KMT2A-YAP1 and VIM-KMT2A fusions.

Mod Pathol 2020 May 27. Epub 2020 May 27.

Foundation Medicine, Inc., 150 Second Street, Cambridge, MA, 02141, USA.

Sarcomas are driven by diverse pathogenic mechanisms, including gene rearrangements in a subset of cases. Rare soft tissue sarcomas containing KMT2A fusions have recently been reported, characterized by a predilection for young adults, sclerosing epithelioid fibrosarcoma-like morphology, and an often aggressive course. Nonetheless, clinicopathologic and molecular descriptions of KMT2A-rearranged sarcomas remain limited. Read More

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http://dx.doi.org/10.1038/s41379-020-0582-4DOI Listing

High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen.

Sci Data 2020 May 27;7(1):160. Epub 2020 May 27.

Department of Cell Biology, Charles University, Viničná 7, Prague, Czech Republic.

The plasticity of cancer cell invasion represents substantial hindrance for effective anti-metastatic therapy. To better understand the cancer cells' plasticity, we performed complex transcriptomic and proteomic profiling of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition (MAT). As amoeboid migratory phenotype can fully manifest only in 3D conditions, all experiments were performed with 3D collagen-based cultures. Read More

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http://dx.doi.org/10.1038/s41597-020-0499-2DOI Listing

Collaborative study for the establishment of Infliximab Biological Reference Preparation Batch 1.

Pharmeur Bio Sci Notes 2020 ;2020:49-52

European Directorate for the Quality of Medicines & HealthCare, Council of Europe, Strasbourg, France.

Two preparations of the chimeric anti-Tumour Necrosis Factor (TNF) monoclonal antibody Infliximab were formulated and lyophilised at the National Institute for Biological Standards & Control (NIBSC) prior to evaluation in a collaborative study for their suitability to serve as a World Health Organization (WHO) International Standard (IS)/European Pharmacopoeia (Ph. Eur.) Biological Reference Preparation (BRP) for the potency assay of Infliximab. Read More

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January 2020

NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8 T cell responses capable of curing multi-focal cancer.

J Immunother Cancer 2020 May;8(1)

Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Oregon, USA

Background: High-dose radiotherapy (RT) is known to be immunogenic, but is rarely capable of driving clinically relevant abscopal antitumor immunity as monotherapy. RT is known to increase antigen presentation, type I/II interferon responses, and immune cell trafficking to irradiated tumors. Bempegaldesleukin (NKTR-214) is a CD122-preferential interleukin 2 (IL-2) pathway agonist that has been shown to increase tumor-infiltrating lymphocytes, T cell clonality, and increase PD-1 expression. Read More

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http://dx.doi.org/10.1136/jitc-2019-000464DOI Listing

A newborn with a large NTRK fusion positive infantile fibrosarcoma successfully treated with larotrectinib.

Pediatr Blood Cancer 2020 May 26:e28330. Epub 2020 May 26.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.

Infantile fibrosarcoma (IFS) is a rare pediatric cancer that typically presents early in life. Surgical resection is commonly curative; however, resection is sometimes not possible requiring additional multimodal treatment. IFS commonly harbors a fusion in one of the neurotrophic receptor tyrosine kinase (NTRK) genes. Read More

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http://dx.doi.org/10.1002/pbc.28330DOI Listing

Ferroptosis at the crossroads of infection, aging and cancer.

Cancer Sci 2020 May 21. Epub 2020 May 21.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Cancer is one of the primary causes of human mortality worldwide despite persistent efforts and developments. No independent life on earth can live without iron whereas some species can without oxygen. Iron provides us with a double-edged sword. Read More

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http://dx.doi.org/10.1111/cas.14496DOI Listing

Cardiovascular safety of rapidly accelerated fibrosarcoma B-type and/or mitogen-activated extracellular signal-regulated kinase inhibitors: A mixed approach combining a meta-analysis and a pharmacovigilance disproportionality analysis.

Arch Cardiovasc Dis 2020 May 1. Epub 2020 May 1.

Department of Pharmacology, CHU de Caen, 14000 Caen, France; Department of Cardiology, CHU de Caen, 14000 Caen, France; Department of Dermatology, CHU de Caen, 14000 Caen, France.

Background: The risk of cardiovascular adverse events from rapidly accelerated fibrosarcoma B-type (BRAF) and mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors is not fully characterized.

Aim: To evaluate the cardiovascular adverse events risks related to BRAF and/or MEK inhibitors in randomized placebo-controlled clinical trials and in the real-life setting.

Methods: We used two approaches. Read More

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http://dx.doi.org/10.1016/j.acvd.2020.03.014DOI Listing

Low-grade fibromyxoid sarcoma: A potentially useful histologic finding.

Histopathology 2020 May 16. Epub 2020 May 16.

Mayo Clinic, Jacksonville, FL, United States.

Low-grade fibromyxoid sarcomas (LGFMS) are malignant fibroblastic tumors first described by Evans in 1987 . While clinically indolent in the early stages of disease, LGFMS are associated with late metastases in patients with longer clinical follow up. LGFMS tend to occur in young adults, yet can occur across a wide age range. Read More

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http://dx.doi.org/10.1111/his.14142DOI Listing

Adipose mesenchymal stromal/stem cells expanded by a GMP compatible protocol displayed improved adhesion on cancer cells in flow conditions.

Ann Transl Med 2020 Apr;8(8):533

Stem Cell Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano (PN), Italy.

Background: Adipose tissue derived mesenchymal stromal/stem cells (ASC) can be expanded using supernatant rich in growth factors (SRGF) as Good Manufacturing Practice compatible additive, instead of fetal bovine serum (FBS). After transendothelial migration, ASC can migrate to cancer masses where they can release active substances. Due to their homing and secretion properties ASC can be used as targeted drug delivery vehicles. Read More

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http://dx.doi.org/10.21037/atm.2020.04.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214883PMC

Adhesion modulates cell morphology and migration within dense fibrous networks.

J Phys Condens Matter 2020 May 7;32(31):314001. Epub 2020 May 7.

CFisUC, Department of Physics, University of Coimbra, Rua Larga, 3004-516 Coimbra, Portugal.

One of the most fundamental abilities required for the sustainability of complex life forms is active cell migration, since it is essential in diverse processes from morphogenesis to leukocyte chemotaxis in immune response. The movement of a cell is the result of intricate mechanisms, that involve the coordination between mechanical forces, biochemical regulatory pathways and environmental cues. In particular, epithelial cancer cells have to employ mechanical strategies in order to migrate through the tissue's basement membrane and infiltrate the bloodstream during the invasion stage of metastasis. Read More

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http://dx.doi.org/10.1088/1361-648X/ab7c17DOI Listing

Optimized Dose of Dendritic Cell-based Vaccination in Experimental Model of Tumor Using Artificial Neural Network.

Iran J Allergy Asthma Immunol 2020 Apr 16;19(2):172-182. Epub 2020 Apr 16.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.

Previous studies have demonstrated that maturation of dendritic cells (DCs) by pathogenic components through pathogen-associated molecular patterns (PAMPs) such as Listeria monocytogenes lysate (LML) or CpG DNA can improve cancer vaccination in experimental models. In this study, a mathematical model based on an artificial neural network (ANN) was used to predict several patterns and dosage of matured DC administration for improved vaccination. The ANN model predicted that repeated co-injection of tumor antigen (TA)-loaded DCs matured with CpG (CpG-DC) and LML (List-DC) results in improved antitumor immune response as well as a reduction of immunosuppression in the tumor microenvironment. Read More

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http://dx.doi.org/10.18502/ijaai.v19i2.2770DOI Listing

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 1;1865(9):158733. Epub 2020 May 1.

Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy. Electronic address:

The farnesoid-X-receptor (FXR) is validated target in the cholestatic disorders treatment. Obeticholic acid (OCA), the first in class of FXR agonist approved for clinical use, causes side effects including acute liver decompensation when administered to cirrhotic patients with primary biliary cholangitis at higher than recommended doses. The V-Maf avian-musculoaponeurotic-fibrosarcoma-oncogene-homolog-G (Mafg) and nuclear factor-erythroid-2-related-factor-2 (Nrf2) mediates some of the downstream effects of FXR. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158733DOI Listing

Preparation and Preliminary Evaluation of 68Ga-Acridine: An Attempt to Study the Potential of Radiolabeled DNA Intercalator as a PET Radiotracer for Tumor Imaging.

Anticancer Agents Med Chem 2020 May 1. Epub 2020 May 1.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai - 400085. India.

Introduction: Acridine is a well-known DNA intercalator and thereby gets easily inserted within DNA. As uncontrolled rapid cell division is one of the primary characteristics of the tumors, it is expected that acridine or its suitable derivatives will have preferential accumulation in the tumorous lesions. Therefore, an attempt was made to radiolabel an acridine derivative with 68Ga and study the potential of the 68Ga-acridine complex as a PET agent for tumor imaging. Read More

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http://dx.doi.org/10.2174/1871520620666200502002609DOI Listing
May 2020
2.469 Impact Factor

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

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http://dx.doi.org/10.1111/vco.12604DOI Listing

Recurrent Phyllodes Tumour of the Breast Transforming to a Fibrosarcoma.

Cureus 2020 Mar 29;12(3):e7457. Epub 2020 Mar 29.

Pathology, Ziauddin University Hospital, Karachi, PAK.

Phyllodes tumours of the breast are characterized by having both an epithelial as well as stromal component and these usually comprise almost 3% of all fibroepithelial tumours. They are exceptional in this aspect to convert into a stromal sarcoma of the breast after multiple recurrences. To the best of our knowledge, there are only three case reports regarding this in the available literature as it is an exceptional change. Read More

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http://dx.doi.org/10.7759/cureus.7457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187999PMC

Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats.

Vet Sci 2020 Apr 27;7(2). Epub 2020 Apr 27.

LABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.

Tumors of mesenchymal origin are rarely reported in the pancreas. Therefore, this study characterized 17 feline non-epithelial pancreatic tumors, including clinical data, histopathology, and immunohistochemistry. Seventeen feline pancreatic tissue samples were investigated histopathologically and immunohistochemically. Read More

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http://dx.doi.org/10.3390/vetsci7020055DOI Listing

Review of Potential Significance of Mutations of , and Detected Using Next Generation Sequencing (NGS) in Dermal Fibrosarcoma Arising in Dermatofibrosarcoma Protuberans.

Folia Med (Plovdiv) 2020 03;62(1):17-22

Holy Cross Oncology Centre, Kielce, Poland.

We examined a status of fibrosarcoma arising in dermatofibrosarcoma protuberans of 64-year-old male patient. A dermal, solid, grayish-yellow, desmin-negative trichrome-bluish tumor measured 1.5 cm in diameter pT1a (edition 8 pTNM). Read More

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http://dx.doi.org/10.3897/folmed.62.e48003DOI Listing

Multiple neurofibromas plus fibrosarcoma with familial NF1 pathogenicity: A case report.

World J Clin Cases 2020 Apr;8(7):1306-1310

Department of Radiology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.

Background: Neurofibromatosis (NF) is a genetic disease consisting of seven types, of which types 1 to 4 are caused by a dominant autosomal gene mutation; such disease sometimes arises in patients with NF type 1. However, it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type 1, as no reports have been published on this issue. Here, we report a case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural cavity. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i7.1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176624PMC

RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.

Mol Ther Oncolytics 2020 Jun 30;17:138-152. Epub 2020 Mar 30.

Department of Neurobiology, School of Life Sciences, China Medical University, Shenyang 110122, People's Republic of China.

The blood-tumor barrier limits the delivery of therapeutic drugs to brain tumor tissues. Selectively opening the blood-tumor barrier is considered crucial for effective chemotherapy of glioma. RNA-binding proteins have emerged as crucial regulators in various biologic processes. Read More

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http://dx.doi.org/10.1016/j.omto.2020.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163051PMC

NTRK-rearranged mesenchymal tumours: diagnostic challenges, morphological patterns and proposed testing algorithm.

Pathology 2020 Jun 9;52(4):401-409. Epub 2020 Apr 9.

Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.

Oncogenic fusions involving neurotrophic receptor tyrosine kinase (NTRK) genes are being increasingly identified in a range of mesenchymal tumours unrelated to infantile fibrosarcoma or cellular congenital mesoblastic nephroma, where the canonical ETV6-NTRK3 fusion was first described more than two decades ago. Recognition of these NTRK-rearranged tumours poses a diagnostic challenge to surgical pathologists due to their non-specific clinical and pathological features. However, their recognition is of heightened importance, particularly in locally advanced and metastatic sarcomas, due to the recent availability of selective and highly effective targeted therapy. Read More

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http://dx.doi.org/10.1016/j.pathol.2020.02.004DOI Listing
June 2020
2.188 Impact Factor

[Spindle cell/sclerosing rhabdomyosarcoma: a clinicopathological study of 20 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Apr;49(4):336-342

Department of Pathology, Xijing Hospital, Fourth Military Medical University, Shaanxi Xi'an 710032, China.

To study the clinicopathological features and immunophenotype of spindle cell/sclerosing rhabdomyosarcoma (SRMS) in adults and children, as well as its correlation with the expression and gene-mutations of MYOD1. Twenty cases of SRMS were collected at Xijing Hospital, Fourth Military Medical University from 2009 to 2019. These cases were evaluated for clinical, pathological, and immunohistochemical features. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190816-00453DOI Listing

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.

J Hematol Oncol 2020 Apr 7;13(1):32. Epub 2020 Apr 7.

Instituto de Investigaciones Biomedicas "Alberto Sols", CSIC-UAM, Madrid, Spain.

Background: In the search for novel antibody-drug conjugates (ADCs) with therapeutic potential, it is imperative to identify novel targets to direct the antibody moiety. CD13 seems an attractive ADC target as it shows a differential pattern of expression in a variety of tumors and cell lines and it is internalized upon engagement with a suitable monoclonal antibody. PM050489 is a marine cytotoxic compound tightly binding tubulin and impairing microtubule dynamics which is currently undergoing clinical trials for solid tumors. Read More

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http://dx.doi.org/10.1186/s13045-020-00865-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140356PMC

Antitumor and Antiangiogenic Properties of Gold(III) Complexes Containing Cycloaurated Triphenylphosphine Sulfide Ligands.

Inorg Chem 2020 Apr 7;59(8):5662-5673. Epub 2020 Apr 7.

Centre for Advanced Materials and Industrial Chemistry, School of Science, RMIT University, G.P.O. Box 2476, Melbourne 3001, Australia.

A family of stable anticancer gold(III)-based therapeutic complexes containing cyclometalated triphenylphosphine sulfide ligands have been prepared. The anticancer properties of the newly developed complexes [AuCl{κ-2-CHP(S)Ph}] (), [Au(κ-SCNEt){κ-2-CHP(S)Ph}]PF (), [AuCl(dppe){κ-2-CHP(S)Ph}]Cl (), and [Au(dppe){κ-2-CHP(S)Ph}][PF] () were investigated toward five human cancer cell lines [cervical (HeLa), lung (A549), prostate (PC3), fibrosarcoma (HT1080), and breast (MDA-MB-231)]. cytotoxicity studies revealed that compounds - displayed potent cell growth inhibition (IC values in the range of 0. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.0c00423DOI Listing

Emerging soft tissue tumors with kinase fusions: An overview of the recent literature with an emphasis on diagnostic criteria.

Genes Chromosomes Cancer 2020 Apr 3. Epub 2020 Apr 3.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

A recent breakthrough in the classification of soft tissue tumors (STT) has been a significant expansion in the number of neoplasms associated with NTRK and other kinase related fusions. This is important not only for diagnostic purposes, but also because it opens new avenues for targeted therapy. Indeed, recent clincal trials have shown significant benefit across multiple tumor-types, prompting approval of NTRK inhibitors for clinical use in the setting of advanced/metastatic NTRK-rearranged neoplasms. Read More

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http://dx.doi.org/10.1002/gcc.22846DOI Listing

[Dermatofibrosarcoma protuberans : clinico-pathological aspects and management].

Rev Med Suisse 2020 Apr;16(688):640-645

Département de dermatologie et vénéréologie, CHUV, 1011 Lausanne.

The dermatofibrosarcoma protuberans (DFSP) is the most common form of low-grade cutaneous sarcoma; its infiltrating growth occurs by fingerlike projections, which explain the high rate of recurrence in case of inappropriate surgical procedure. Based on an extensive review of the existing literature, we propose here to discuss the actual criteria for early recognition, diagnosis and optimal take of care of DFSP. Read More

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Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin.

J Toxicol Sci 2020 ;45(4):219-226

Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University.

Tumor necrosis factor receptor-associated factor 2 (TRAF2) is an essential component of tumor necrosis factor-α (TNF-α) signaling that regulates nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) pathways, and compelling evidence has demonstrated that TRAF2 suppresses TNF-α-induced cytotoxicity. On the other hand, it has been reported that oxidative stress-induced cytotoxicity is potentiated by TRAF2, indicating that TRAF2 both positively and negatively regulates stress-induced cytotoxicity in a context-specific manner. However, the causal role of TRAF2 in DNA damage response (DDR) remains to be explored. Read More

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http://dx.doi.org/10.2131/jts.45.219DOI Listing
January 2020

Fibrosarcoma with sarcomatosis and metastasis in a FeLV-negative cat.

Vet Clin Pathol 2020 Mar 30;49(1):143-146. Epub 2020 Mar 30.

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

A 6-year-old, spayed female, mixed shorthair cat presented to the emergency service at The Ohio State University Veterinary Medical Center for evaluation of hypercalcemia, a right eye mass, and multiple intrathoracic and intra-abdominal masses. Cytologic evaluation of one of the abdominal masses revealed a uniform population of large, anaplastic mesenchymal cells found individually, in loose aggregates, and occasionally associated with pink, extracellular matrix. The cytology was consistent with a malignant mesenchymal neoplasm, with primary consideration given to fibrosarcoma and hemangiosarcoma. Read More

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http://dx.doi.org/10.1111/vcp.12842DOI Listing

Cerium oxide nanoparticles: A promising tool for the treatment of fibrosarcoma in-vivo.

Mater Sci Eng C Mater Biol Appl 2020 Apr 6;109:110533. Epub 2019 Dec 6.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

In this study, we used cerium oxide nanoparticles and evaluated their anti-cancer effects in a mouse model of fibrosarcoma. For evaluation of anti-cancer effects of nanoceria, tumor volume measurement, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, quantitative real-time PCR (qPCR) for Bax and Bcl2 genes, a panel of liver and kidney function tests and hematoxylin-eosin staining were done. Nanoceria dominantly accumulated in the tumor and it could significantly decrease tumor growth and volume in tumor-bearing mice that received nanoceria for four weeks. Read More

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http://dx.doi.org/10.1016/j.msec.2019.110533DOI Listing

Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion.

Ann Oncol 2019 11 24;30 Suppl 8:viii31-viii35. Epub 2019 Dec 24.

Radiologic Institute, Center for Pediatric, Adolescent and Women's Medicine, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart.

Background: The ETV6-NTRK3 gene fusion is present in the majority of cases of infantile fibrosarcoma (IFS) and acts as a potent oncogenic driver. We report the very rapid, complete, and sustained response of an advanced, chemotherapy-refractory, recurrent IFS to targeted treatment with the oral tropomyosin receptor kinase (TRK) inhibitor larotrectinib.

Patient And Methods: A male infant born with a large congenital IFS of the tongue had the tumour surgically resected at age 4 days. Read More

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http://dx.doi.org/10.1093/annonc/mdz382DOI Listing
November 2019

Identifying patients with NTRK fusion cancer.

Ann Oncol 2019 11 24;30 Suppl 8:viii16-viii22. Epub 2019 Dec 24.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:

Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and the recent Food and Drug Administration approval of larotrectinib, it is now clinically important to accurately and efficiently identify patients with neurotrophic TRK (NTRK) fusion-driven cancer. These oncogenic fusions occur when the kinase domain of NTRK1, NTRK2 or NTRK3 fuse with any of a number of N-terminal partners. NTRK fusions are characteristic of a few rare types of cancer, such as secretory carcinoma of the breast or salivary gland and infantile fibrosarcoma, but they are also infrequently seen in some common cancers, such as melanoma, glioma and carcinomas of the thyroid, lung and colon. Read More

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http://dx.doi.org/10.1093/annonc/mdz384DOI Listing
November 2019

Giant Thyroid Fibrosarcoma- A Case Report.

Iran J Otorhinolaryngol 2020 Mar;32(109):109-112

Department of Otorhinolaryngology, Gregorio Marañón Hospital, Madrid, SPAIN.

Introduction: Thyroid gland fibrosarcomas are extremely rare tumors, and only very few cases have been described in the literature. There are no set recommendations along with follow-ups regarding the treatment of these tumors. Moreover, the prognosis is poor with a very short life expectancy. Read More

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http://dx.doi.org/10.22038/ijorl.2019.39741.2310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085927PMC

Pristimerin inhibits the proliferation of HT1080 fibrosarcoma cells by inducing apoptosis.

Oncol Lett 2020 Apr 17;19(4):2963-2970. Epub 2020 Feb 17.

Department of Orthopedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Fibrosarcoma is a soft tissue sarcoma that is classified as a rare cancer. Therefore, no standard anti-tumor drug therapy has been established for fibrosarcoma. Although pristimerin (PM) has been reported to exert an anti-tumor effect on various types of cancer, no studies have examined the therapeutic effect of PM on soft tissue sarcoma. Read More

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http://dx.doi.org/10.3892/ol.2020.11405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068646PMC

4-methylumbelliferone inhibits clonogenic potency by suppressing high molecular weight-hyaluronan in fibrosarcoma cells.

Oncol Lett 2020 Apr 5;19(4):2801-2808. Epub 2020 Feb 5.

Department of Radiation Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Aomori 036-8564, Japan.

The inflammatory response is closely associated with cancer cell survival. It has been reported that inflammatory signaling cascades promote tumor survival and exert detrimental effects in normal tissue. Hyaluronans have different cellular functions depending on their molecular weights and high molecular weight-hyaluronan (HMW-HA) exhibits anti-inflammatory effects. Read More

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http://dx.doi.org/10.3892/ol.2020.11370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068617PMC

Primary intracranial fibrosarcoma in a southern sea otter Enhydra lutris nereis.

Dis Aquat Organ 2020 Mar 26;138:207-213. Epub 2020 Mar 26.

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Southern sea otters Enhydra lutris nereis, a threatened marine mammal species, face numerous environmental and infectious disease challenges in their native habitat of coastal California, USA. However, there are few published cases describing neoplasia in sea otters despite their relatively long life span when cared for in aquarium settings. An 18 yr old neutered male southern sea otter, born and raised in human care, presented with an acute onset of seizures and dull mentation. Read More

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http://dx.doi.org/10.3354/dao03457DOI Listing

The Value of H3K27me3 Immunohistochemistry in Differentiating Malignant Peripheral Nerve Sheath Tumour with Its Histologic Mimickers.

Asian Pac J Cancer Prev 2020 Mar 1;21(3):699-705. Epub 2020 Mar 1.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Background: Diagnosis of malignant peripheral nerve sheath tumor (MPNST) is rather challenging due to its divergent morphologic heterogeneity and lack of specific ancillary test. The emergence of H3K27 trimethylation (H3K27me3) as a new immunohistochemistry (IHC) marker for MPNST have recently available to assist pathologists in differentiating MPNST from other histologic mimics. We aim to study the expression pattern of H3K27me3 in MPNST and its histologic mimickers and their association with the clinicopathological data. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.699DOI Listing

Gene-gene interactions between BMP4 and ARHGAP29 among non-syndromic cleft lip only (NSCLO) trios from western Han Chinese population.

Int J Clin Exp Pathol 2020 1;13(2):295-301. Epub 2020 Feb 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Cleft Lip and Palate, West China Hospital of Stomatology, Sichuan University Chengdu, China.

Background: Genome-wide association studies (GWAS) have found more than 20 genes associated with a risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). However, the interactions between these risk genes have been rarely reported.

Methods: Here we selected 47 Single Nucleotide Polymorphisms (SNP) from previous GWASs and tested for possible interactions among 302 NSCL/P case-parent trios from a western Han Chinese population to further explore the genetic etiology of NSCL/P. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061801PMC
February 2020

Presentation and Management of Dermatofibrosarcoma Protuberans: a Single Center Protocol.

Indian J Surg Oncol 2020 Mar 21;11(1):35-40. Epub 2019 Nov 21.

2Department of Plastic & Reconstructive Surgery, Tata Medical Center, Kolkata, India.

Dermatofibrosarcoma protuberans (DFSP) is a slow growing dermal tumor with a very low metastatic potential but with significant subclinical extension and capacity for local destruction with local recurrence rates ranging from 0 to 50%. Controversy exists regarding margin width and excision techniques, with some advocating Mohs surgery and others wide excision. We reviewed the excision technique along with the recurrence rates at a tertiary care center in eastern India. Read More

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http://dx.doi.org/10.1007/s13193-019-01007-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064730PMC

Soft tissue sarcomas in infants. Case series.

Arch Argent Pediatr 2020 04;118(2):e162-e165

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Los sarcomas de partes blandas en menores de 2 años son infrecuentes. Durante 2007-2017, 445 pacientes con sarcomas de partes blandas fueron tratados en nuestra Institución; 6 (el 0,5 %) eran menores de 2 años. Se analizaron los resultados clínicos y oncológicos en este grupo. Read More

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http://dx.doi.org/10.5546/aap.2020.e162DOI Listing

Tumor Size Matters-Understanding Concomitant Tumor Immunity in the Context of Hypofractionated Radiotherapy with Immunotherapy.

Cancers (Basel) 2020 Mar 18;12(3). Epub 2020 Mar 18.

Department of Radiation Oncology, University of California at Los Angeles (UCLA), Los Angeles, CA 90095-1714, USA.

The purpose of this study was to determine the dynamic contributions of different immune cell subsets to primary and abscopal tumor regression after hypofractionated radiation therapy (hRT) and the impact of anti-PD-1 therapy. A bilateral syngeneic FSA1 fibrosarcoma model was used in immunocompetent C3H mice, with delayed inoculation to mimic primary and microscopic disease. The effect of tumor burden on intratumoral and splenic immune cell content was delineated as a prelude to hRT on macroscopic T1 tumors with 3 fractions of 8 Gy while microscopic T2 tumors were left untreated. Read More

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http://dx.doi.org/10.3390/cancers12030714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140082PMC

Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells.

ACS Chem Biol 2020 04 20;15(4):871-877. Epub 2020 Mar 20.

Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.

Ferroptosis is a type of cell death caused by the pathogenic accumulation of lipid hydroperoxides. Pharmacological mechanisms to induce ferroptosis may provide a way to kill cancer cells that are resistant to other forms of cell death like apoptosis. Nonetheless, the proteins that regulate ferroptotic sensitivity in cancer cells remain incompletely understood. Read More

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http://dx.doi.org/10.1021/acschembio.0c00086DOI Listing

A case of cellular variants of Sclerosing epithelioid fibrosarcoma resembling Plasmacytoma/Myeloma: Diagnostic difficulty in the fine needle aspiration.

Int J Surg Case Rep 2020 7;68:228-233. Epub 2020 Mar 7.

Department of Organ Pathology, Shimane University School of Medicine, Japan.

Introduction: Sclerosing epithelioid sarcoma (SEF) is a rare fibroblastic sarcoma. It is classically composed of cords of epithelioid cells embedded in a hyalinized stroma; however, cases of cellular variants also exist. A cellular variants of SEF can mimic Plasmacytoma/Myeloma (PM) and myoepithelioma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078455PMC

3,5-Dicaffeoyl-epi-quinic acid inhibits the PMA-stimulated activation and expression of MMP-9 but not MMP-2 via downregulation of MAPK pathway.

Z Naturforsch C J Biosci 2020 Mar;75(3-4):113-120

Marine Biotechnology Center for Pharmaceuticals and Foods, Silla University, Baegyang-daero 700 beon-gil 140, Sasang-gu, Busan 46958, Korea.

Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, are very important gelatinases that are overexpressed during tumor metastasis. Up to date, several MMP inhibitors have been developed from natural sources as well as organic synthesis. In the present study, the MMP-2 and MMP-9 inhibitory effects of 3,5-dicaffeoyl-epi-quinic acid (DCEQA), a caffeoylquinic acid derivative isolated from Atriplex gmelinii, were investigated in phorbol 12-myristate 13-acetate (PMA)-treated human HT1080 fibrosarcoma cells. Read More

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http://dx.doi.org/10.1515/znc-2019-0163DOI Listing