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PLoS One 2019 20;14(2):e0211824. Epub 2019 Feb 20.

Department of Physical Education, Federal University of Viçosa, Viçosa, MG-Brazil.

The objective of this study was to verify the effects of aerobic exercise associated with tryptophan (TRP) supplementation on hyperalgesia, as well as on cortisol, IL-6 and TNF concentrations in female rats with experimental fibromyalgia (FM). Female Wistar rats (initial body weight: ~ 350 g; age: 12 months) were randomly divided into 5 groups: CON (Control); F (Fibromyalgia induced); FE (Fibromyalgia induced plus exercise); FES (Fibromyalgia induced plus exercise and TRP supplementation) and FS (Fibromyalgia induced plus TRP supplementation). Fibromyalgia was induced with two injections (20 μL) of acidic saline (pH 4. Read More

BMJ Open 2019 Feb 19;9(2):e025436. Epub 2019 Feb 19.

School of Nursing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction: A growing body of evidence is identifying the link between a history of child maltreatment and a variety of adverse health outcomes ultimately leading to significant social and healthcare burden. Initial work has identified a potential association between child maltreatment and the development of a selection of somatic and visceral central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, temporomandibular joint disorder, chronic lower back pain, chronic neck pain, chronic pelvic pain, interstitial cystitis, vulvodynia, chronic prostatitis, tension-type headache, migraine, myofascial pain syndrome, irritable bowel syndrome and restless legs syndrome.

Methods And Analysis: Primary electronic searches will be performed in the Embase, MEDLINE, PubMed, Scopus, PyscINFO, CINAHL and Cochrane Library databases and a number of Grey Literature sources including child protection and paediatric conference proceedings. Read More

BMJ Open 2019 Feb 19;9(2):e022306. Epub 2019 Feb 19.

Faculty of Health Sciences of Trairi - UFRN/FACISA, Federal University of Rio Grande do Norte, Santa Cruz, Brazil.

Introduction: Physical exercises have been recommended to improve the overall well-being of patients with fibromyalgia, with the main objective of repairing the effects of lack of physical conditioning and of improving the symptoms, especially pain and fatigue. Although widely recommended and widely known, few studies support the use of Pilates as an effective method in improving the symptoms of the disease, comparing it with other well-founded exercise modalities. This protocol was developed to describe the design of a randomised controlled study with a blind evaluator that evaluates the effectiveness of mat Pilates, comparing it with aquatic aerobic exercises, in improving pain in women with fibromyalgia. Read More

BMJ Open 2019 Jan 25;9(1):e023742. Epub 2019 Jan 25.

LIEN, EA4685, University of Western Brittany (UBO), Brest, France.

Introduction: The main symptom of fibromyalgia (FM) is diffuse pain. There is currently no aetiological treatment for FM. However, all pain associations and best practice guidelines strongly advocate the practice of aerobic physical activity to improve the symptoms of FM subjects. Read More

Expert Rev Endocrinol Metab 2012 May;7(3):301-308

b Endocrine & Metabolic Unit, The University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia.

Primary stress-related diseases such as chronic fatigue syndrome, fibromyalgia or chronic widespread pain have been associated with altered activity of the hypothalamic-pituitary-adrenal axis due to measured relative hyper- or hypo-cortisolism in basal or experimentally stimulated states. A hereditary risk to development of these diseases has been proposed. Corticosteroid-binding globulin (CBG), a plasma transport vehicle for cortisol, may play a more active role in the hypothalamic-pituitary-adrenal axis. Read More

Drugs 2019 Feb 19. Epub 2019 Feb 19.

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Mirogabalin besylate (hereafter mirogabalin) [Tarlige] is an orally administered gabapentinoid developed by Daiichi Sankyo for the treatment of peripheral neuropathic pain (PNP), including diabetic PNP and post-herpetic neuralgia. The drug binds to and modulates the αδ-1 subunit of the voltage-gated calcium channels widely found in the nervous system in areas that mediate pain transmission and processing. Mirogabalin has a unique binding profile and long duration of action. Read More

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Pain & Neuroscience Laboratories, Daiichi-Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.

Mirogabalin, a novel ligand for the αδ subunit of voltage-gated calcium channels, is under the development for the treatment of neuropathic pain. Mirogabalin specifically and potently binds to αδ subunits, and it shows analgesic effects in both peripheral and central neuropathic pain models in rats. To expand pharmacological findings on mirogabalin and provide additional information of its potential for chronic pain therapy, we examined the effects of mirogabalin in 2 experimental models of fibromyalgia, namely, the intermittent cold stress model (ICS model) and the unilateral intramuscular acidic saline injection model (Sluka model). Read More

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

Clin J Pain 2019 Feb 12. Epub 2019 Feb 12.

Dept. Veterinary and Biomedical Sciences, University of Minnesota, St. Paul MN.

Objectives: Fibromyalgia syndrome (FMS) is a chronically painful condition whose symptoms are widely reported to be exacerbated by stress. We hypothesized that female patients with FMS differ from healthy female controls in their sympathetic responses, a fact that may unmask important biomarkers and factors that contribute to the etiology of FMS.

Methods: In a pilot study, blood pressure (BP), skin temperature, thermogenic activity, circulating glucose, and pain sensitivity of 13 patients and 11 controls at room temperature (24°C) were compared to that after exposure to cold (19°C). Read More

Fed Pract 2018 Aug;35(8):22-25

is a Hospitalist and the Director of Resident Education at VA Boston Healthcare System and an Assistant Professor of Medicine at Harvard University in Massachusetts and supervises the VA Boston Medical Forum Chief Resident case conferences. All patients or their surrogate decision makers understand and have signed appropriate patient release forms. This article has received an abbreviated peer review.

J Pain 2019 Feb 11. Epub 2019 Feb 11.

National Data Bank for Rheumatic Diseases; University of Kansas School of Medicine - Wichita 1035 N. Emporia, Ste 288, Wichita, KS 67214. Electronic address:

Med Mal Infect 2019 Feb 11. Epub 2019 Feb 11.

FHU INOVPAIN, centre d'évaluation et de traitement de la douleur, CHU de Timone, pôle de neurosciences cliniques, 13005 Marseille, France.

Lyme disease is caused by bacteria of the B. burgdorferi sensu lato complex, and can give polymorphic clinical manifestations that can affect several organs such as the skin, the central nervous system, or the joints. In recent years, patients' associations and physicians have been supporting the hypothesis that this infection would manifest as chronic generalized musculoskeletal pain symptoms, named "chronic Lyme disease". Read More

Pain 2019 Jan 16. Epub 2019 Jan 16.

Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, United States.

A critical component of brain network architecture is a robust hub structure, wherein hub regions facilitate efficient information integration by occupying highly connected and functionally central roles in the network. Across a wide range of neurological disorders, hub brain regions seem to be disrupted, and the character of this disruption can yield insights into the pathophysiology of these disorders. We applied a brain network-based approach to examine hub topology in fibromyalgia, a chronic pain condition with prominent central nervous system involvement. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14452

Department of Psychiatry, Seoul National University Hospital.

Complex regional pain syndrome (CRPS) and fibromyalgia (FM) share many features. Both can cause severe pain and are considered to have a mechanism of action, including dysfunction of the sympathetic nervous system. However, they have clinical differences in pain range and degree. Read More

Psychosom Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.

Objective: Enhanced odor sensitivity is a phenomenon that potentially underlies conditions such as multiple chemical sensitivity (MCS). Currently, there are no treatments that have been shown to effectively decrease odor sensitivity. Given similarities of odor hypersensitivity/MCS to pain sensitization disorders such as fibromyalgia, there may be a potential for interventions that improve pain tolerance to modulate odor sensitivity. Read More

Int J Eat Disord 2019 Jan;52(1):42-50

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

Objective: To examine psychiatric and somatic correlates of DSM-5 eating disorders (EDs)-anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)-in a nationally representative sample of adults in the United States.

Method: A national sample of 36,309 adult participants in the national epidemiologic survey on alcohol and related conditions III (NESARC-III) completed structured diagnostic interviews (AUDADIS-5) to determine psychiatric disorders, including EDs, and reported 12-month diagnosis of chronic somatic conditions. Prevalence of lifetime psychiatric disorders and somatic conditions were calculated across the AN, BN, and BED groups and a fourth group without specific ED; multiple logistic regression models compared the likelihood of psychiatric/somatic conditions with each specific ED relative to the no-specific ED group. Read More

Rheumatol Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.

Fibromyalgia is a multifaceted disease. The clinical picture of fibromyalgia covers numerous comorbidities. Each comorbidity stands as a distinct condition. Read More

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.

Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis is consistent with mitochondrial dysfunction and oxidative stress, we evaluated the pathophysiological correlation among these factors studying some proteins involved in the mitochondrial homeostasis. We focused our attention on the roles of peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α), mitofusin2 (Mfn2), and coenzyme Q10 (CoQ10) in reserpine-induced myalgic (RIM) rats that manifest fibromyalgia-like chronic pain symptoms. Read More

Holist Nurs Pract 2019 Mar/Apr;33(2):111-120

Faculty of Nursing, University of Castilla-La-Mancha, Ciudad Real, Spain (Drs Onieva-Zafra, Parra-Fernández and Fernandez-Martinez).

Despite the plethora of treatments available for patients with fibromyalgia, there is insufficient evidence to date as to what the ideal treatment approach is. This study sought to determine the effectiveness of a home program of audio-recorded guided imagery relaxation on people with fibromyalgia. This experimental 8-week longitudinal trial design was undertaken with 60 people diagnosed with fibromyalgia who were randomly assigned to either a guided imagery intervention group or a control group. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):98-104. Epub 2019 Feb 8.

Department of Surgical, Medical and Molecular Pathology, Critical and Care Medicine, University of Pisa, Italy.

Although the mechanisms underlying fibromyalgia are not yet clear, many attempts have been made to implement pharmacological therapy and help patients manage its psychological and physical symptoms. Recent evidence has shown that an interdisciplinary multidimensional approach encompassing psychological factors, emotion regulation strategies and education on illness is more effective in improving quality of life, both in the short- and long-term, than usual treatments alone. The purpose of this review is to provide an updated overview of the available literature regarding the role of psychoeducation on fibromyalgia symptoms and health outcomes. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):75-80. Epub 2019 Feb 8.

NeuroMuscularFunction/Research Group, School of Exercise & Sport Sciences, Department of Medical Sciences, University of Turin, Italy.

Objectives: Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):63-69. Epub 2019 Feb 6.

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

Objectives: Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculoskeletal pain, fatigue and disordered sleep, and often associated with neuropsychiatric and cognitive symptoms. Current treatment options are only partially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of this study was to evaluate the efficacy and safety of HBOT after fewer sessions than generally used, chosen on the basis of pre-clinical and clinical data showing its rapid and sustained antinociceptive effect. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):105-113. Epub 2019 Feb 8.

Clinical and Oncological Psychology, Città della Salute e della Scienza Hospital of Turin, Turin, Italy.

The concept of resilience varies according to the context in which it is used. Resilience is broadly defined as a protective factor that makes people less vulnerable to future adverse life events, in this implying the previous occurrence of an adverse event that has to be confronted before individual equilibrium can be restored. This definition can be applied to fibromyalgia and other chronic pain situations. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):3-10. Epub 2019 Feb 6.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Fibromyalgia is characterised by chronic pain, fatigue and functional symptoms. Its aetiopathogenesis is still a matter of debate, but various pharmacological and non-pharmacological therapies are currently available for its treatment. We review the literature concerning the most recent findings related to the aetiopathogenesis, diagnosis, clinical aspects and treatment of FM published between January 2018 and January 2019. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8.

Division of Rheumatology, McGill University Health Centre, Quebec, Canada and Alan Edwards Pain Management Unit, McGill University Health Centre, Quebec, Canada.

Fibromyalgia syndrome (FM) is an enigma. During the past three decades, with the gradual acceptance of the validity of FM, it is variously under-, over and misdiagnosed. Evidence-based interdisciplinary guidelines have suggested a comprehensive clinical assessment to avoid this diagnostic conundrum. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):11-12. Epub 2019 Feb 6.

Department of Internal Medicine H, Tel Aviv Sourasky Medical Centre, Israel.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):81-89. Epub 2019 Feb 8.

Dipartimento di Biopatologia e Biotecnologie Mediche, Università di Palermo, Italy.

Objectives: Hyperbaric oxygen therapy (HBOT) has been used as treatment for different clinical conditions, including fibromyalgia (FM). HBOT modulates brain activity, ameliorates chronic pain and modifies the ratio of immune cells. Clinical studies have provided evidence that FM is associated with immune system dysregulation. Read More

Med Mal Infect 2019 Feb 5. Epub 2019 Feb 5.

Institut de neurosciences de la Timone UMR7289, campus santé, Aix-Marseille université, 13005 Marseille, France; Pôle de psychiatrie, Assistance publique-Hôpitaux de Marseille, 13005 Marseille, France; Fondation FondaMental, 13005 Créteil, France.

Approximately 10% of patients presenting with Lyme disease experience fatigue, musculoskeletal pain, concentration disorders, or short-term memory deficits in the six months following treatment. This entity has been defined as post-Lyme disease syndrome or post-treatment Lyme disease syndrome. The pathophysiology of this syndrome is unknown, but neither persistence of the bacterium nor effectiveness of antibiotics are currently reported in the literature. Read More

J Complement Integr Med 2019 Feb 7. Epub 2019 Feb 7.

Center of Research on Himalayan Sustainability and Development, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, India.

From the last few decades, there are increasing incidences of disorders like premature aging, cardiovascular disease, multiple sclerosis, fibromyalgia, and Alzheimer's disease In addition to medication, researchers have found that yoga, a mind-body therapy, can be used as an alternative medicine. Yoga combines specific physical postures, breathing techniques, relaxation and meditation that improve mental and physical health of the body. The purpose of this review is to collate the research evidences claiming health benefits of performing traditional yogic practices. Read More

Ann Med 2019 Feb 8:1-29. Epub 2019 Feb 8.

a Faculdade de Ciências da Nutrição e Alimentação , Universidade do Porto , Rua Dr. Roberto Frias , 4200-465 Porto , Portugal.

Fibromyalgia (FM) is a chronic non-degenerative disease, whose nutritional therapy seems controversial. This systematic review aimed to synthesize the knowledge about the effect of dietary interventions on patient reported outcomes (PRO) and inflammation in patients with FM. Six electronic databases - PubMed, BioMed Central, Cochrane library, EMBASE, LILACS and ISI - were searched for clinical trials, in which a dietary intervention in patients with FM diagnosed was conducted. Read More

Pain Manag 2019 01;9(1):1-4

Future Science Group, Unitec House, 2 Albert Place, London, N31QB, UK.

PM R 2019 Feb 6. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Denver Health Medical Center, Denver, CO.

Background: Female chronic pelvic pain is estimated to affect up to 24% of adult women, many of whom have a component of myofascial pelvic pain. Although an association of joint hypermobility and pelvic pain has been hypothesized, limited data are available that estimate the prevalence of joint hypermobility in this population.

Objective: To estimate the prevalence of generalized hypermobility spectrum disorder (G-HSD) among female patients with chronic myofascial pelvic pain and examine the association between G-HSD and other frequent pelvic pain-associated complaints. Read More

Psychol Health Med 2019 Feb 6:1-16. Epub 2019 Feb 6.

f Department of Psychology , East Tennessee State University , Johnson City , TN , USA.

Fibromyalgia is a chronic illness characterized by pain and fatigue. Persons with fibromyalgia experience increased the risk for poor mental and physical health-related quality of life, which may be dependent on multiple factors, including health beliefs, such as confidence in physicians and the health-care system, and health behaviors, such as treatment adherence. Respondents with fibromyalgia (n = 409) were recruited nationally, via support organizations, and completed self-report measures: Multidimensional Health Profile - Health Functioning Index (MHP-H), Short-Form-36 Health Survey (SF-36v2), and Medical Outcomes Study (MOS) Measure of Patient Adherence - General Adherence Items. Read More

Arthritis Care Res (Hoboken) 2019 Feb 6. Epub 2019 Feb 6.

Rush University Medical Center, Chicago, Illinois.

Objective: Recent studies have suggested that fibromyalgia is inaccurately diagnosed in the community, and that ~75% of persons reporting a physician diagnosis of fibromyalgia would not satisfy published criteria. To investigate possible diagnostic misclassification, we compared expert physician diagnosis with published criteria.

Methods: In a university rheumatology clinic, 497 patients completed the Multidimensional Health Assessment Questionnaire (MD-HAQ) and the 2010 American College of Rheumatology preliminary diagnostic criteria modified for self-administration during their ordinary medical visits. Read More

Arthritis Care Res (Hoboken) 2019 Feb 6. Epub 2019 Feb 6.

Oregon Health Sciences University, Portland.

MMW Fortschr Med 2019 Feb;161(2):45-48

Schön Klinik Harthausen, Dr.-Wilhelm-Knarr Weg 1-3, D-83043, Bad Aibling, Deutschland.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Escola de Ciências, Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, Brazil.

Generalized pain and fatigue are both hallmarks of fibromyalgia, a syndrome with an indefinite aetiology. The treatment options for fibromyalgia are currently limited, probably due to its intricate pathophysiology. Thus, further basic and clinical research on this condition is currently needed. Read More

J Rheumatol 2019 Feb;46(2):127-129

Stony Brook University, Stony Brook, New York, USA.

Clin Rheumatol 2019 Jan 31. Epub 2019 Jan 31.

Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia.

Introduction: Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibromyalgia and CFS in a rheumatology clinic population. Read More

J Pain Res 2019 17;12:395-404. Epub 2019 Jan 17.

Department of Rheumatology, Medisch Spectrum Twente, Enschede, Netherlands.

Purpose: Generalized pain hypersensitivity is frequently observed in chronic pain conditions. Currently, identification is based on expert clinical opinion, and in very few cases combined with quantitative sensory testing. The objectives of this study were to develop and evaluate a short self-report measure of generalized pain hypersensitivity: a generalized pain questionnaire (GPQ). Read More

Clin Neurophysiol 2019 Jan 18. Epub 2019 Jan 18.

Unitat d'Electromiografia, Servei de Neurologia, Hospital Clínic, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Universitat de Barcelona, Hospital Clinic I Provincial de Barcelona, Spain.

Testing of exteroceptive electromyographic modulation of ongoing voluntary muscle activity is of increasing interest as a diagnostic tool in clinical neurophysiology. The cutaneous silent period (CSP) is a robust and reproducible nociceptive EMG suppression, mediated at the spinal level by small-diameter A-delta afferents. The techniques and physiological principles of CSP testing, which are a fundamental prerequisite for a valid and thoughtful clinical application, are reviewed separately in part 1 (Kofler et al. Read More

Postgrad Med 2019 Jan 31:1-14. Epub 2019 Jan 31.

c School of Nursing , Linfield College , Portland , OR , USA.

Chronic pain is a common public health problem that has a detrimental impact on patient health, quality of life (QoL), and function, and poses a substantial socioeconomic burden. Evidence supports the redefinition of chronic pain as a distinct disease entity, not simply a symptom of injury or illness. Chronic pain conditions are characterized by three types of pain pathophysiology (i. Read More

J Affect Disord 2019 02 3;245:1098-1105. Epub 2018 Dec 3.

Psychiatric Research Unit, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark. Electronic address:

Background: It is acknowledged that fibromyalgia (FM) as a medical (rheumatological) disorder and major depressive disorder (MDD) as a mental disorder often co-occurs, but the inconsistency is prevailing at study-level and no overall estimate of the co-occurrence exist.

Aims: This systematic review and meta-analysis aimed to estimate the overall point- and life-time prevalence of MDD among FM patients based on structured clinical interviews (SCI); and to estimate the point-prevalence of MDD among FM patients based on screening symptom scales (SSS).

Method: The electronical databases MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and PsycINFO were searched for papers that reported on prevalence of MDD among FM patients. Read More

Neuropsychobiology 2019 Jan 30:1-7. Epub 2019 Jan 30.

Department of Psychology, University of Michigan, Ann Arbor, Michigan,

Glutamate is an amino acid that functions as an excitatory neurotransmitter. It has also been associated with somatic and psychiatric distress and is implicated in the pathophysiology of psychiatric disorders such as schizophrenia. Ingestion of dietary glutamate, such as monosodium glutamate (MSG), has been mechanistically linked with greater distress among patients with chronic pain conditions, though findings have been equivocal. Read More

Pain Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Objective: To analyze 1) the independent association of physical fitness, positive affect, and negative affect with the different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue) and 2) whether the interactions of physical fitness, positive affect, and negative affect were associated with fatigue over and above the independent association.

Design: Cross-sectional study in 420 women with fibromyalgia.

Setting: Fibromyalgia associations from southern Spain. Read More

Eur J Phys Rehabil Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Physical Therapy, Instituto de Investigación Biosanitaria Granada (IBIS Granada), University of Granada (UGR), Granada, Spain.

Introduction: Fibromyalgia (FM) is a chronic illness characterised by the presence of generalised musculoskeletal pain among other symptoms, which reduce the quality of life of the patient. Clinical interventions such as patient education on central pain management could lead to promising results. The aim of this study is to evaluate the effectiveness of education techniques on the main symptoms such as pain, quality of life, anxiety, functionality or catastrophisation in the treatment of FM. Read More

Disabil Rehabil 2019 Jan 29:1-8. Epub 2019 Jan 29.

d Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Occupational Therapy Department, Ghent University , Ghent , Belgium.

Objectives: Literature suggests that graded and multicomponent therapy improves outcomes in fibromyalgia, but there is no conclusive evidence in which combination to be used. This study focused on the effect of a multicomponent therapy in fibromyalgia when a combination of exercise therapy and cognitive behavioural therapy was applied. Additionally, predictors for dropping out were explored as research reports high dropout rates. Read More

Discov Med 2018 11;26(144):197-206

Department of Psychiatry, State University of New York (SUNY) Upstate Medical University, Syracuse, NY 13210, USA.

Background: The cold pressor test (CPT) has been used in experimental paradigms to measure pain tolerance. It is used clinically to evaluate for opioid-induced hyperalgesia (OIH), as part of the clinical evaluation of fibromyalgia, to document reversal of OIH by low dose naltrexone (LDN), and to document the clinical response of fibromyalgia to LDN.

Methods: We reviewed charts of 254 outpatients admitted to addiction medicine with chronic opioid treatment for pain, opioid addiction, or fibromyalgia. Read More

J Bodyw Mov Ther 2019 Jan 24;23(1):74-81. Epub 2018 Oct 24.

College of Human & Health Sciences, Swansea University, Singleton Park, Swansea, Wales, SA2 8PP, UK. Electronic address:

Background: Myofascial release (MFR) is used to restore tissue extensibility of the fascia tissue and is considered to be useful in a number of clinical settings such as low back pain, ankle injuries, fibromyalgia, and headaches. There is, however, despite the popularity of MFR in manual therapy, little consensus on whether it leads to biomechanical, systemic or interoceptive outcomes.

Aims: This study aimed to explore the immediate biomechanical (increased elasticity for increased range of motion), systemic (local vs. Read More

Health Educ Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Medical Psychology and Psychotherapy, Medical Sociology and Rehabilitation Sciences, Julius-Maximilians-University of Würzburg, Würzburg, Germany.

The objective was to evaluate the effectiveness of a self-management patient education programme for fibromyalgia syndrome (FMS) as compared with usual care education in inpatient rehabilitation. In a multicentre cluster-randomized controlled trial, 583 inpatients in 3 rehabilitation centres received an advanced self-management patient education programme or usual care education. Patients completed questionnaires at admission, discharge and after 6 and 12 months. Read More