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Expert Rev Clin Pharmacol 2022 May 20. Epub 2022 May 20.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin,  China.

Background: Recent studies have found potential benefits of vitamin D in relieving pain, while the results from randomized controlled trials of vitamin D for fibromyalgia have been promising. We conducted a systematic review and meta-analysis to evaluate the efficacy of vitamin D in the treatment of fibromyalgia.

Research Design And Methods: PubMed, Web of Science, Embase, and Cochrane Library databases were systematically searched. Read More

Mil Med 2022 May 21. Epub 2022 May 21.

School of Nursing, San Diego State University, San Diego, CA 92182-4158, USA.

Introduction: Chronic pain, a persistent or recurrent pain lasting more than 3 months, is a widespread problem among military women due to combat-related injuries and post-deployment stressors. Risk factors associated with chronic pain include gender, mental health, post-traumatic stress disorder, and prior physical or military sexual trauma. The most common prevalence of chronic pain is musculoskeletal (e. Read More

EBioMedicine 2022 May 17;80:104055. Epub 2022 May 17.

Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: Emerging evidence suggests that dysbiosis in gut microbiota may contribute to the occurrence or development of several rheumatic diseases. Since gut microbiota dysbiosis is potentially modifiable, it has been postulated to be a promising preventive or therapeutic target for rheumatic diseases. However, the current understanding on the potential associations between gut microbiota and rheumatic diseases is still inadequate. Read More

Musculoskelet Sci Pract 2022 Apr 29;60:102570. Epub 2022 Apr 29.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Infantile Sciences (DINOGMI), University of Genova, Campus of Savona, SV, Italy.

Background: Recent studies found that fibromyalgia may underly neuropathic conditions affecting the peripheral nervous system. Moreover, clinical observations and preliminary reports suggest the existence of body perceptions distortions (BPD) like "phantom" feelings of swollen hands and feet, similar to those complained by patients with other neuropathic conditions or subjected to experimental procedures affecting the peripheral nervous system.

Objectives: To investigate the prevalence of self-reported BPD in Italian people with fibromyalgia through an online survey administered with the help of the associations of patients distributed nationwide. Read More

Curr Rheumatol Rev 2022 May 18. Epub 2022 May 18.

Professor of Medicine, Geisel School of Medicine at Dartmouth.

Rheumatologists encounter psychiatric illness daily in their practice, yet formal training in rheumatology rarely provides instruction in the psychiatric conditions commonly faced. In this article, we review common clinical situations that involve psychiatric disease, their relationship to the rheumatologic condition, how they impact the clinical presentation and their management. We illustrate key principles in a case-based format and reflect on the management of the psychiatric components. Read More

BMC Musculoskelet Disord 2022 May 19;23(1):471. Epub 2022 May 19.

GEFISER, Sociedad Española de Reumatología, Barcelona, Spain.

Objectives: To determine the prevalence and characteristics of post-COVID-19 (PC) in fibromyalgia (FM) patients.

Methods: Retrospective, multi-centric, observational study, comparing a group of FM patients (FM group) with another group of patients with other rheumatic diseases (RD group). COVID-19 diagnosis was established by positive polymerase chain reaction or antigen during acute infection or by positive antibodies thereafter. Read More

Int J Psychophysiol 2022 May 16. Epub 2022 May 16.

UMIT Tirol, University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria. Electronic address:

Fibromyalgia syndrome (FMS) is a chronic condition of widespread pain accompanied by symptoms like depression, fatigue and cognitive impairments. In addition to central nervous pain sensitization, emotional dysregulation may be involved in FMS pathogenesis. This study investigated emotional influences on cognitive processing in FMS. Read More

Pain 2022 May 19. Epub 2022 May 19.

Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa.

Abstract: Multisensory sensitivity (MSS) to non-painful stimuli has been identified as a risk factor for the presence of coexisting chronic pain conditions (COPCs). However, it remains unclear whether MSS can differentiate pain phenotypes involving different levels of central sensitivity. Both pain-free and those with chronic pain, particularly fibromyalgia (FM), migraine or low back pain (LBP) were recruited, with pain co-morbidities assessed. Read More

Pain Med 2022 May 19. Epub 2022 May 19.

Lecturer of Clinical Neurophysiology, Neuro diagnostic research center, Beni-Suef University, Beni-Suef, Egypt.

Objectives: The aim of this work was to explore the expression of miR-320a level in fibromyalgia patients in comparison to healthy controls, and to clarify its impact on the severity of symptoms and the cerebral processing of pain assessed by middle latency somatosensory evoked potentials (SSEPs).

Design: Case-control study.

Setting: Rheumatology and Neurology outpatient clinics. Read More

Pain 2022 May 19. Epub 2022 May 19.

Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, Quebec, Canada.

Abstract: Alterations in the composition and function of the gut microbiome in women with fibromyalgia have recently been demonstrated, including changes in the relative abundance of certain bile acid metabolizing bacteria. Bile acids can affect multiple physiological processes, including visceral pain, but have yet to be explored for association to the fibromyalgia gut microbiome. In this study, 16S rRNA sequencing and targeted metabolomic approaches were used to characterize the gut microbiome and circulating bile acids in a cohort of 42 women with fibromyalgia and 42 healthy controls. Read More

JAMA Netw Open 2022 May 2;5(5):e2212939. Epub 2022 May 2.

Department of Pharmaceutical Economics and Policy, Massachusetts College of Pharmacy and Health Sciences, Boston.

Importance: Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia.

Objective: To investigate the comparative effectiveness and acceptability associated with pharmacological treatment options for fibromyalgia.

Data Sources: Searches of PubMed/MEDLINE, Cochrane Library, Embase, and Clinicaltrials. Read More

Eur Arch Psychiatry Clin Neurosci 2022 May 19. Epub 2022 May 19.

Department of Educational Sciences, University of Extremadura, 06006, Badajoz, Spain.

Malingering consists of the production of false physical or psychological symptoms motivated by external incentives that are normally reproduced in pathologies that are not related to organic origin or there are no laboratory tests for their diagnosis, as is the case of mixed anxiety-depressive disorder and fibromyalgia syndrome. The objective of this research consisted of comparing the profile of simulative patients with fibromyalgia and mixed anxiety-depressive disorder to obtain a profile and facilitate its detection in initial interviews. The research was carried out with 78 patients (42 patients with fibromyalgia and 36 patients with mixed anxiety-depressive disorder) who were administered the professional's structured clinical judgment, the Beck Depression Inventory, the State-Trait Anxiety Questionnaire, and the Structured Symptom Simulation Inventory. Read More

Pain Med 2022 May 19. Epub 2022 May 19.

Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain.

Purpose: To assess the effects of pain neuroscience education (PNE) on patients with fibromyalgia (FM) in terms of pain intensity, fibromyalgia impact, anxiety, and pain catastrophizing.

Methods: A systematic review and meta-analysis of randomized controlled trials was conducted. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated with RStudio software for relevant outcomes and were pooled in a meta-analysis using the random effects model. Read More

Syst Rev 2022 May 18;11(1):97. Epub 2022 May 18.

School of Nursing, University of Victoria, PO Box 1700 STN CSC, Victoria, British Columbia, V8P 2Y2, Canada.

Background: Violence towards women with disabilities is most commonly perpetrated by current or former intimate partners and more than half of disabled women experience intimate partner violence in their lifetime. Disabilities differ by presence, type, and complexity, yet are commonly researched collectively. A more nuanced understanding of the relationship between intimate partner violence and episodic disability is required to better support women living with these concurrent challenges. Read More

J Exerc Rehabil 2022 Apr 26;18(2):133-140. Epub 2022 Apr 26.

Department of Physical Education, State University of Ponta Grossa, Ponta Grossa, Brazil.

The aim of this study was to compare the physical fitness and cardiac autonomic activity among women with moderate and severe fibromyalgia (FM) and healthy women. This study included 35 women with FM (age: 46.2±8. Read More

World J Psychiatry 2022 Apr 19;12(4):615-622. Epub 2022 Apr 19.

Rheumatology Unit, Evangélico Mackenzie Hospital, Curitiba 80730-420, Brazil.

Background: Fibromyalgia (FM) patients are treated with antidepressants, and in most cases, these drugs lose efficacy or present side effects. Intravenous lidocaine (IL) is an anesthetic drug used in some FM trials.

Aim: To systematically review the safety and efficacy of IL in FM patients. Read More

Pain 2022 May 17. Epub 2022 May 17.

Genesis Research Services, Broadmeadow, NSW, Australia.

Abstract: Ambroxol is a multifaceted drug with primarily mucoactive and secretolytic actions, along with anti-inflammatory, antioxidant, and local anaesthetic properties. It has a long history of use in the treatment of respiratory tract diseases and has shown to be efficacious in relieving sore throat. In more recent years, ambroxol has gained interest for its potential usefulness in treating neuropathic pain. Read More

Ann Med 2022 Dec;54(1):1403-1422

Department of Psychology, University of Jaén, Jaén, Spain.

Introduction: The pathophysiology of fibromyalgia (FM) is related to central sensitisation (CS) to pain. Algometry allows assessing CS based on dynamic evoked pain. However, current algometrýs protocols require optimising, unifying and updating. Read More

Clin Exp Rheumatol 2022 May 4. Epub 2022 May 4.

School of Behavioural Sciences, The Academic College of Tel Aviv-Yaffo, Israel.

Objectives: While symptoms of fibromyalgia (FM) and psychological distress are directly linked, indirect effects are also apparent. The aim of the present study was to develop an explanatory model for the effect of FM on women's psychological distress and identify possible protective and risk factors.

Methods: This study comprised of total of 293 women aged 20-68 (M= 34. Read More

J Clin Med 2022 Apr 27;11(9). Epub 2022 Apr 27.

Department of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain.

In recent years, antioxidant supplements have become popular to counteract the effects of oxidative stress in fibromyalgia and one of its most distressing symptoms, pain. The aim of this systematic review was to summarize the effects of antioxidant supplementation on pain levels perceived by patients diagnosed with fibromyalgia. The words used respected the medical search terms related to our objective including antioxidants, fibromyalgia, pain, and supplementation. Read More

Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Physiotherapy, Faculty of Medicine, Speech Therapy and Occupational Therapy (FOFITO), University of São Paulo (USP), R. Cipotânea, 51-Vila Butantã, São Paulo 05360-160, Brazil.

Health education is one of the main items to enable the promotion of health for individuals with fibromyalgia (FM) in Primary Health Care (PHC) in Brazil. The purpose of this study was to validate a multidisciplinary educational health promotion program called (Fibro Friends) for individuals with FM. Methodological research involving 23 health professionals (expert judges) and 45 individuals with FM (target audience) used an instrument to assess the objectives, proposed themes and initiatives, relevance, writing style, and structure of the program through the Delphi technique. Read More

Open Access Rheumatol 2022 5;14:87-95. Epub 2022 May 5.

Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

Objective: To explore patient perspectives on disease activity and experiences, as well as medication use of a group of fibromyalgia patients attending a single-centre rheumatology public hospital outpatient setting.

Methods: Patients seen in fibromyalgia clinic within a rheumatology unit from July 2016 to December 2019 were posted a voluntary survey with questionnaires pertaining to patient-reported measures of disease impact (FIQR), fatigue (MFI-20) and psychological distress (K10). A free-text section allowed description of disease impact. Read More

Front Med (Lausanne) 2022 25;9:870584. Epub 2022 Apr 25.

Programa de Pós-Graduação em Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasilia, Brazil.

Leprosy causes significant pain in affected patients, especially those experiencing reactional states. Fibromyalgia is characterized by widespread pain and is often accompanied by fatigue. Confusion between the clinical manifestations of fibromyalgia and those of leprosy reactions is possible at the primary care level, the first contact with the health system in most cases. Read More

J Coll Physicians Surg Pak 2022 May;32(5):689

Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Null. Read More

J Palliat Med 2022 May 10. Epub 2022 May 10.

Division of Cancer Medicine, Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. Read More

Female Pelvic Med Reconstr Surg 2022 May 5. Epub 2022 May 5.

Departments of Obstetrics & Gynecology.

Objectives: The aim of this study was to determine the relationship between opioid prescriptions and number of chronic pain conditions in women with interstitial cystitis (IC).

Methods: This was a cross-sectional study. Women diagnosed with IC based on International Classification of Diseases, Ninth Revision/Tenth Revision codes over an 11-year period (2010-2020) were identified from electronic medical records. Read More

Infection 2022 May 10. Epub 2022 May 10.

Department of Upper Gastroenterology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Reumatol Clin (Engl Ed) 2022 May 3. Epub 2022 May 3.

Grup de Recerca en Serveis Sanitaris i Resultats en Salut (GRESSIRES), Serveis de Salut Integrats Baix Empordà (SSIBE), Palamós, Spain.

Background: In Spain, the prevalence of different rheumatic diseases is known mainly through the EPISER studies coordinated by the Spanish Society of Rheumatology and based on surveys in a population sample. The aim of our study is to describe the prevalence in 2016 of different rheumatic diseases in the population residing in Baix Empordà according to healthcare coding records.

Materials And Methods: Observational, descriptive and cross-sectional study carried out on the population attended from 2016 to 2017 in SIBBE (Serveis de Salut Integrats del Baix Empordà), an organizational service that includes all the healthcare facilities in the Baix Empordà area with a unique information system. Read More

Rehabilitacion (Madr) 2022 May 3. Epub 2022 May 3.

Departamento de Historia, Geografía y Filosofía, Campus Universitario de Jerez, Universidad de Cádiz, Cádiz, España; Instituto Universitario de Investigación para el Desarrollo Social y Sostenible (INDESS), Campus Universitario de Jerez, Universidad de Cádiz, Cádiz, España.

The main objective of the study is to analyse the scientific evolution of the research field of fibromyalgia and biomechanics. A search was carried out in Web of Science, from 1985 to 2021. With those results, a bibliometric map of keywords was created with VOSviewer. Read More

Expert Opin Pharmacother 2022 May 4:1-11. Epub 2022 May 4.

Division of Rheumatology and Clinical Immunology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Introduction: Fibromyalgia (FM) is a chronic pain syndrome associated with fatigue, insomnia, dyscognition, and emotional distress. Critical illness mechanisms include central sensitization to nociceptive and non-nociceptive stimuli often resulting in hypersensitivity to all sensory input.

Areas Covered: The clinical presentation of FM can vary widely and therefore requires therapies tailored to each patient's set of symptoms. Read More