10,686 results match your criteria Fibromyalgia


Oxygen-ozone therapy as support and palliative therapy in 50 cancer patients with fatigue - A short report.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8030-8033

Tumor Center, CFS, Fibromyalgia and Oxygen Ozone Therapy Unit, Mede Clinic, Sacile (PN), Italy.

Objective: Fatigue may be cause by all cancer treatments, maybe because the tissue damage or the build-up of dead cells derived products.

Patients And Methods: At the Mede Clinic in Sacile, Pordenone, Italy, from February 2016 to May 2018 we studied 50 patients with cancer and fatigue (15 with breast cancer, 12 with lung cancer, 11 with colon cancer, 5 with renal cancer, 3 with prostate cancer, 2 with melanoma and 2 hepatocellular carcinoma). Patients were treated with Auto Hemotransfusion (GAE) according to the SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, two times a week for one month and then twice monthly as maintenance therapy. Read More

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November 2018
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Physical Activity and Sleep in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort LifeLines.

Pain Res Manag 2018 4;2018:5801510. Epub 2018 Nov 4.

University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, Netherlands.

Objective: The aim of the current study was to compare physical activity and sleep duration between patients with chronic fatigue syndrome (CFS), patients with fibromyalgia syndrome (FMS), and controls and to examine the association between physical activity level and sleep duration with symptom severity within these patient groups.

Methods: This study used data of LifeLines, a general population cohort in which 1.0% (=943, 63. Read More

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November 2018

Medically Unexplained Physical Symptoms in Hospitalized Patients: A 9-Year Retrospective Observational Study.

Front Psychiatry 2018 23;9:626. Epub 2018 Nov 23.

Section of Psychiatry, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

"Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Read More

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November 2018

Effect of Kinesio taping on clinical symptoms in people with fibromyalgia: A randomized clinical trial.

J Back Musculoskelet Rehabil 2018 Nov 23. Epub 2018 Nov 23.

Background: Fibromyalgia syndrome (FMS) is a disorder characterized by chronic widespread pain and muscle soreness. Because of its high prevalence, many therapeutic approaches have been proposed with the aim of improving overall physical function and reducing pain. Since low adherence is one of the major limitations among these patients, treatments that do not interfere with their daily routines, such as KT, would be a feasible option. Read More

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November 2018

Somatosensory temporal discrimination is impaired in fibromyalgia.

J Clin Neurosci 2018 Oct 24. Epub 2018 Oct 24.

Gazi University, Faculty of Medicine, Department of Neurology, Motor Control Laboratory, Besevler, 06510 Ankara, Turkey.

Objective: Fibromyalgia is the prototypical central sensitivity syndrome which is associated with increased sensitivity to pain and other stimuli. In this study, we aimed to evaluate whether somatosensory temporal discrimination ability, which provides information about central processing of sensory stimuli, was impaired in patients with fibromyalgia.

Methods: Fifteen patients with fibromyalgia and 15 healthy subjects participated in the study. Read More

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October 2018

Frequency of mental disorders among chronic pain patients with or without fibromyalgia in Japan.

Neuropsychopharmacol Rep 2018 Dec 11;38(4):167-174. Epub 2018 Aug 11.

Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.

Aim: To explore the characteristics of psychiatric morbidity in chronic pain patients who present with or without fibromyalgia.

Methods: Patients are referred to our chronic pain clinic from primary medical institutions, as we are a secondary medical institution. Although some patients have chronic pain, they have no clear organic disorder such as rheumatoid arthritis to account for the pain. Read More

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December 2018
3 Reads

Longitudinal Occurrence and Predictors of Patient-Provider Discordance Between Global Assessments of Disease Activity in Rheumatoid Arthritis: A Case-Control Study.

Arthritis Care Res (Hoboken) 2018 Nov 30. Epub 2018 Nov 30.

Division of Rheumatology.

Objective: The objective was to identify longitudinal predictors of discordance between patients with rheumatoid arthritis (RA) and their health care providers, where patient global assessment of disease activity is substantially higher than provider global assessment.

Methods: This retrospective case-control study included 102 cases with positive discordance (ie, ≥25 mm between patient and provider global assessments) and 102 controls without discordance who were matched for age, sex, RA duration, and Clinical Disease Activity Index (CDAI). Data were collected at the baseline visit (date of diagnosis or earliest available visit), the index visit (participation in a previous cross-sectional study), and at up to 11 additional visits before the index visit. Read More

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November 2018

Hyperthermia in rheumatic diseases. A promising approach?

Reumatologia 2018 31;56(5):316-320. Epub 2018 Oct 31.

Department of Gerontology, Public Health, and Didactics, National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw, Poland.

Hyperthermia is a method applied in the treatment of many diseases, including rheumatic diseases. There are relatively few reports concerning the role of that method in the treatment of these diseases, and most studies have not been randomised. Hyperthermia includes directed application of thermal energy. Read More

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October 2018

Cross-sectional analysis of the associations between fibromyalgia and diabetes mellitus.

Reumatologia 2018 31;56(5):275-278. Epub 2018 Oct 31.

Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel.

Background: The fibromyalgia syndrome (FMS) is a chronic condition consisting of widespread musculoskeletal pain and tenderness together with mood and cognitive dysfunction. Diabetes mellitus (DM) is a common condition causing significant and detrimental morbidity and mortality. Data on the association between the two conditions is scarce and mainly based on small populations therefore lack solid evidence. Read More

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October 2018

Diagnostic and therapeutic challenge - fibromyalgia.

Reumatologia 2018 31;56(5):273-274. Epub 2018 Oct 31.

Clinic of Early Arthritis, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

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October 2018

Developing an optimized strategy with transcranial direct current stimulation to enhance the endogenous pain control system in fibromyalgia.

Expert Rev Med Devices 2018 Dec 3;15(12):863-873. Epub 2018 Dec 3.

a Laboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation , Spaulding Rehabilitation Hospital, Harvard Medical School , Boston , MA , USA.

Introduction: Fibromyalgia affects more than 5 million people in the United States and has a detrimental impact on individuals' quality of life. Current pharmacological treatments provide limited benefits to relieve the pain of fibromyalgia, along with a risk of adverse effects; a scenario that explains the increasing interest for multimodal approaches. A tailored strategy to focus on this dysfunctional endogenous pain inhibitory system is transcranial direct current stimulation (tDCS) of the primary motor cortex. Read More

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December 2018

A study of the description of exercise programs evaluated in randomized controlled trials involving people with fibromyalgia using different reporting tools, and validity of the tools related to pain relief.

Clin Rehabil 2018 Dec 5:269215518815931. Epub 2018 Dec 5.

1 School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.

Rationale:: Exercise programs for the management of fibromyalgia are well recognized as being effective. However, the incomplete descriptions of exercise programs make replication and implementation difficult. Also, existing reporting tools have not been validated in relation to pain relief as well as with each other. Read More

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December 2018
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Are serotonin and noradrenaline reuptake inhibitors effective, tolerable, and safe for adults with fibromyalgia? A Cochrane Review summary with commentary.

Authors:
Frane Grubišić

J Musculoskelet Neuronal Interact 2018 Dec;18(4):404-406

Department of Rheumatology, Physical Medicine and Rehabilitation, University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.

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December 2018

Novel Insights of Effects of Pregabalin on Neural Mechanisms of Intracortical Disinhibition in Physiopathology of Fibromyalgia: An Explanatory, Randomized, Double-Blind Crossover Study.

Front Hum Neurosci 2018 19;12:406. Epub 2018 Nov 19.

Post-Gradaution in Medical Science at Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

The fibromyalgia (FM) physiopathology involves an intracortical excitability/inhibition imbalance as measured by transcranial magnetic stimulation measures (TMS). TMS measures provide an index that can help to understand how the basal neuronal plasticity state (i.e. Read More

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November 2018
1 Read

Pain in spondyloarthritis: A neuro-immune interaction.

Best Pract Res Clin Rheumatol 2017 12 17;31(6):830-845. Epub 2018 Aug 17.

Spondylitis Program, Department of Rheumatology, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Krembil Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada; Department of Immunology, Medical Sciences Building, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Institute of Medical Science, Medical Sciences Building, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

Pain in spondyloarthritis is usually attributed to inflammation. However, treatment with potent biologic agents that control inflammation does not always control the pain. Pain is hence likely to be multifactorial. Read More

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December 2017
1 Read

Are Pain Beliefs, Cognitions, and Behaviors Influenced by Race, Ethnicity, and Culture in Patients with Chronic Musculoskeletal Pain: A Systematic Review.

Pain Physician 2018 Nov;21(6):541-558

Univeristy of Antwerp, Faculty of medicine and health sciences, Department of Rehabilitation Sciences and Physiotherapy, Antwerp, Belgium.

Background: Chronic pain has been considered as a biopsychosocial condition in which cognitive and emotional factors as well as biological factors significantly affect perception of pain. Race, ethnicity and culture have a crucial impact on illness beliefs, health care preferences, help-seeking behaviors, and acceptance of medical interventions.

Objectives: The aim of the present study was to systematically review the current evidence regarding the racial, ethnic and cultural alterations and differences in pain beliefs, cognitions, and behaviors in patients with chronic musculoskeletal pain (MSKP). Read More

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November 2018

Broad cognitive complaints but subtle objective working memory impairment in fibromyalgia patients.

PeerJ 2018 21;6:e5907. Epub 2018 Nov 21.

Department of Clinical Psychology and Psychobiology, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

Background: Cognitive dysfunction in fibromyalgia (FM) encompasses objective cognitive difficulties, as measured in neuropsychological tests, and self-reported cognitive complaints. Although it has been suggested that FM patients display problems in working memory, the data are inconsistent, and the overall working memory status of the patients is unclear. It is also not clear whether the working memory problems are related to cognitive complaints or how the dyscognition is affected by the characteristic clinical symptoms of FM. Read More

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November 2018
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Cognitive behavioral treatments for insomnia (CBT-I) and pain (CBT-P) in adults with comorbid chronic insomnia and fibromyalgia: Clinical outcomes from the SPIN randomized controlled trial.

Sleep 2018 Nov 28. Epub 2018 Nov 28.

Clinical and Health Psychology, University of Florida, FL, USA.

Objectives: To examine the effects of cognitive behavioral treatments for insomnia (CBT-I) and pain (CBT-P) in patients with comorbid fibromyalgia and insomnia.

Methods: 113 patients (Mage=53, SD=10.9) were randomized to eight sessions of CBT-I (n=39), CBT-P (n=37), or a waitlist control (WLC, n=37). Read More

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November 2018
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The efficacy of adding group behavioral activation to usual care in patients with fibromyalgia and major depression: design and protocol for a randomized clinical trial.

Trials 2018 Nov 29;19(1):660. Epub 2018 Nov 29.

Departamento de Psiquiatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Avda. Libertador Bernardo O'Higgins 340, Santiago, Chile.

Background: Fibromyalgia and major depression frequently co-occur. Patients with both conditions have a worse prognosis and higher disability, and their treatment options are scarce. Behavioral activation (BA) may be an especially useful intervention for these patients, as it targets mechanisms of action that seem to be common to both disorders. Read More

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November 2018
2 Reads

Sensing acidosis: nociception or sngception?

J Biomed Sci 2018 Nov 29;25(1):85. Epub 2018 Nov 29.

Institute of Biomedical Sciences, Academia Sinica, 128 Academia Rd. Sec. 2, Taipei, 115, Taiwan.

Background: Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.

Main Body: In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Read More

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November 2018
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[EXPRESS] Fibromyalgia: genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers.

Mol Pain 2018 Nov 29:1744806918819944. Epub 2018 Nov 29.

Università degli Studi di Parma.

Fibromyalgia (FM) is a disease characterized by chronic widespread pain with additional symptoms, such as joint stiffness, fatigue, sleep disturbance, cognitive dysfunction, and depression. Currently FM diagnosis is based exclusively on a comprehensive clinical assessment, according to 2016 ACR criteria, but validated biological biomarkers associated with FM have not yet been identified. Genome-wide association studies investigated genes potentially involved in FM pathogenesis highlighting that genetic factors are possibly responsible for up to 50% of the disease susceptibility. Read More

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November 2018
1 Read

Fragile X-Associated Neuropsychiatric Disorders (FXAND).

Front Psychiatry 2018 13;9:564. Epub 2018 Nov 13.

Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Sacramento, CA, United States.

Fragile X syndrome (FXS) is caused by the full mutation (>200 CGG repeats) in the Fragile X Mental Retardation 1 () gene. It is the most common inherited cause of intellectual disability (ID) and autism. This review focuses on neuropsychiatric disorders frequently experienced by premutation carriers with 55 to 200 CGG repeats and the pathophysiology involves elevated mRNA levels, which is different from the absence or deficiency of fragile X mental retardation protein (FMRP) seen in FXS. Read More

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November 2018
5 Reads

Autonomic dysfunction and HPV immunization: an overview.

Immunol Res 2018 Nov 27. Epub 2018 Nov 27.

Rheumatology Department, National Institute of Cardiology, Mexico City, Mexico.

This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), or fibromyalgia. Read More

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November 2018
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Cardiovascular Responses of Women with Fibromyalgia to a Laboratory Stressor: Does Post-traumatic Stress Disorder Comorbidity Matter?

Pain Med 2018 Nov 22. Epub 2018 Nov 22.

Department of Medicine and Surgery, Psychology, Preventive Medicine and Public Health, Medical Microbiology and Immunology, King Juan Carlos University, Madrid, Spain.

Objectives: This study compared cardiovascular responses to a laboratory trauma-unrelated stressor of two groups of women diagnosed with fibromyalgia (FM), one of them with comorbid post-traumatic stress disorder (PTSD), with a group of healthy controls in order to detect the possible existence of differences linked to comorbidity.

Design: Case-controls.

Methods: Eighteen women diagnosed with FM and comorbid PTSD, 18 women diagnosed with FM and no PTSD, and 38 healthy women were exposed to an arithmetic task with harassment while blood pressure and heart rate were measured during task exposure and recovery. Read More

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November 2018
1 Read

Effectiveness of the muscle energy technique on respiratory muscle strength and endurance in patients with fibromyalgia.

J Back Musculoskelet Rehabil 2018 Nov 16. Epub 2018 Nov 16.

Background: Fibromyalgia is characterized by a chronic and common musculoskeletal system pain that affects cervical mobility and inspiration. This may cause changes in thoracic mechanics.

Objective: To investigate the effectiveness of the muscle energy technique applied to cervical accessory respiratory muscles on respiratory muscle strength and endurance in patients with fibromyalgia. Read More

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November 2018
2 Reads

Advances in orally administered pharmacotherapy for the treatment of migraine.

Expert Opin Pharmacother 2018 Nov 26:1-10. Epub 2018 Nov 26.

c Headache and Fibromyalgia Center, Geriatrics Clinic, Department of Medicine and Science of Aging and Ce.S.I.-Met , "G. D'Annunzio" University of Chieti , Chieti , Italy.

Introduction: Migraine is a common and highly disabling neurological disorder whose acute treatment remains problematic and unsatisfactory in a high percentage of cases. Consequently, there remains a need for new symptomatic therapies that can be easily handled by patients (i.e. Read More

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November 2018
1 Read

Fibromyalgia: Increased reactivity of the muscle membrane and a role of central regulation.

Clin Neurophysiol 2018 Oct 31;130(1):12-19. Epub 2018 Oct 31.

Academic Center for Epileptology Kempenhaeghe, Sterkselseweg 65, 5591 VE Heeze, The Netherlands.

Objective: Fibromyalgia (FM) is characterized by widespread muscle pain and central neural deregulation. Previous studies showed increased muscle fiber conduction velocity (CV) in non-painful muscles of FM patients. This study investigates the relationship between central activation and the CV in FM. Read More

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October 2018
2 Reads

Supervised machine learning to decipher the complex associations between neuro-immune biomarkers and quality of life in schizophrenia.

Metab Brain Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok, 10330, Thailand.

Stable phase schizophrenia is characterized by altered patterning in tryptophan catabolites (TRYCATs) and memory impairments, which are associated with PHEMN (psychosis, hostility, excitation, mannerism and negative) and DAPS (depression, anxiety and physio-somatic) symptoms. This study was carried out to examine the association between TRYCAT patterning, memory impairments, psychopathological features and health-related quality of life (HR-QoL) in schizophrenia. The World Health Organization (WHO) QoL instrument-Abbreviated version (WHO-QoL-BREF), IgA/IgM responses to TRYCATs, cognitive tests, Scale for the Assessment of Negative Symptoms (SANS), Hamilton and Depression (HAMD) and Anxiety (HAMA) Rating Scales and the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale (FF) were measured in 80 schizophrenia patients and 40 controls. Read More

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November 2018
3 Reads

The association between fibromyalgia and female sexual dysfunction: a systematic review and meta-analysis of observational studies.

Int J Impot Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Urology, Malatya Training and Research Hospital, Malatya, Turkey.

Female sexuality in patients with fibromyalgia has received little attention in the literature, and published data have mainly relied upon a small sample size with evident heterogeneity. Our aim was to pool the observational studies on the association between fibromyalgia and sexual dysfunction in female patients to reach a more comprehensive and reliable result. The literature search comprised of Pubmed-Medline, Cochrane, and Embase databases. Read More

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November 2018
11 Reads

Chronic Widespread Pain in a tertiary pain clinic: classification overlap and use of a patient generated quality of life instrument.

Scand J Pain 2018 Nov 22. Epub 2018 Nov 22.

Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.

Background and aims This study has two main aims: (1) To explore the overlap between classification criteria in patients with Chronic Widespread Pain (CWP) and (2) To explore the use of the Patient Generated Index (PGI) as a quality of life (QoL) measure in this patient group. Methods Patients with Widespread Pain (ICD-11: pain in four or more out of five bodily regions, i.e. Read More

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November 2018
3 Reads

Analysis of Real-World Dosing Patterns for the 3 FDA-Approved Medications in the Treatment of Fibromyalgia.

Am Health Drug Benefits 2018 Sep;11(6):293-301

Principal, IQVIA, during the study.

Background: Fibromyalgia is a chronic condition characterized by widespread pain, fatigue, and sleep disturbances that affects approximately 2% to 4% of the adult population in the United States, with minimal real-world data related to the use of medications and associated dosages for this condition.

Objective: To analyze the real-world dosing patterns of the 3 medications approved by the US Food and Drug Administration for fibromyalgia-pregabalin, duloxetine, and milnacipran.

Methods: Using QuintilesIMS' (now IQVIA) electronic medical record data linked to administrative claims, we identified adults with fibromyalgia who were newly prescribed pregabalin, duloxetine, or milnacipran between January 1, 2006, and December 31, 2014. Read More

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September 2018
2 Reads

The level of evidence of medical marijuana use for treating disabilities: a scoping review.

Disabil Rehabil 2018 Nov 20:1-12. Epub 2018 Nov 20.

a College of Public Health and Health Professions , University of Florida , Gainesville , FL , USA.

Purpose: Twenty-nine states have bypassed federal regulations by legalizing marijuana (MJ) either medicinally, recreationally or both. The FDA states that there is no empirical evidence that MJ is effective to treat these disorders. With over a billion individuals living with a disability across the globe, it is crucial to fully research the efficaciousness and safety of medical MJ to treat this population. Read More

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November 2018
2 Reads

Saffron () versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial.

Avicenna J Phytomed 2018 Nov-Dec;8(6):513-523

Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Saffron was found efficient and safe in treatment of neuropsychiatric disorders, in particular depression. We compared the efficacy of saffron with duloxetine in treatment of patients with fibromyalgia.

Materials And Methods: In this double-blind parallel-group clinical trial, outpatients with fibromyalgia were randomized to receive either saffron 15 mg or duloxetine 30 mg starting with 1 capsule per day in the first week followed by 2 capsules per day from week 2 until the end of week 8. Read More

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November 2018
2 Reads

Olfactory and cognitive functioning in patients with fibromyalgia.

Psychol Health Med 2018 Nov 19:1-12. Epub 2018 Nov 19.

a Department of Medicine and Surgery, Public Health, Psychology and Immunology and Medical Microbiology, Odontology and Nursing , Rey Juan Carlos University , Alcorcón (Madrid) , Spain.

Fibromyalgia is a complex syndrome characterized by chronic musculoskeletal pain. Previous research has found impaired olfactory function and cognitive deficits in patients with fibromyalgia. In non-clinical population (middle-aged and elderly populations) an association has been found between olfactory function and cognitive impairment. Read More

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November 2018
6 Reads

AAPT Diagnostic Criteria for Fibromyalgia.

J Pain 2018 Nov 16. Epub 2018 Nov 16.

Epidemiology Group and Aberdeen Centre for Arthritis and Musculoskeletal Health, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.

Fibromyalgia (FM) is a common chronic pain disorder that presents diagnostic challenges for clinicians. Several classification, diagnostic and screening criteria have been developed over the years, but there continues to be a need to develop criteria that reflect the current understanding of FM and are practical for use by clinicians and researchers. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks, (ACTTION) public-private partnership with the United States (U. Read More

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November 2018
8 Reads

Systematic Review of the Efficacy and Safety of Gabapentin and Pregabalin for Pain in Children and Adolescents.

Anesth Analg 2018 Nov 16. Epub 2018 Nov 16.

From the Clinical Pharmacology and Toxicology Research Group, Discipline of Pharmacology, University of Sydney, New South Wales, Australia.

The barriers to opioid use in some countries necessitate the need to identify suitable alternatives or adjuncts for pain relief. The gabapentinoids (gabapentin and pregabalin) are approved for the management of persistent pain in adults, but not in children. Searches were conducted in Embase, Medline, Scopus, and Web of Science up until November 2017, for randomized controlled trials that investigated the analgesic effects of gabapentin or pregabalin in children and adolescents <18 years of age. Read More

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November 2018
2 Reads

Cold Water Pressor Test Differentially Modulates Functional Network Connectivity in Fibromyalgia Patients Compared with Healthy Controls.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:578-582

Fibromyalgia is a multifaceted chronic pain condition of unknown etiology. Conditioned pain modulation (CPM) such as cold water pressor test of the foot, is widely documented as being disrupted in patients with fibromyalgia. To date, the mechanisms underlying such dysregulation of the descending control of pain in fibromyalgia remain poorly understood. Read More

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July 2018
1 Read

Rapid-onset hyponatremia and delirium following duloxetine treatment for postherpetic neuralgia: Case report and literature review.

Medicine (Baltimore) 2018 Nov;97(46):e13178

Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, Zhejiang, China.

Rationale: Hyponatremia following duloxetine treatment has been reported in patients with major depressive disorder, fibromyalgia, diabetic neuropathy, or sciatic pain. The manifestations of duloxetine-induced hyponatremia are varying in different individuals. The overall prognosis for this type of hyponatremia is favorable if properly managed. Read More

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November 2018
5 Reads

The Patient-Reported Outcomes Thermometer-5-Item Scale (5T-PROs): Validation of a New Tool for the Quick Assessment of Overall Health Status in Painful Rheumatic Diseases.

Pain Res Manag 2018 23;2018:3496846. Epub 2018 Oct 23.

Rheumatological Clinic, Università Politecnica delle Marche, Jesi, Ancona, Italy.

Objective: To investigate the construct validity, reliability (internal consistency and retest reliability), and feasibility of the patient-reported outcomes thermometer-5-item scale (5T-PROs), a new tool to measure overall health status in patients with painful chronic rheumatic diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (axialSpA), and fibromyalgia (FM).

Methods: Consecutive patients have been involved in this study. The following analyses were performed to establish the validity of the 5T-PROs: (1) principal component factor analysis was used to identify the presence of a relatively small number of underlying latent factors than can be used to represent relations among sets of many variables; (2) Cronbach's alpha was calculated as an indicator of internal consistency; and (3) Pearson product-moment correlations were conducted to assess the convergent validity. Read More

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December 2018
8 Reads

Characterizing classes of fibromyalgia within the continuum of central sensitization syndrome.

J Pain Res 2018 23;11:2551-2560. Epub 2018 Oct 23.

Patient and Health Impact Pfizer Inc., Groton, CT, USA.

Background: While fibromyalgia (FM) is characterized by chronic widespread pain and tenderness, its presentation among patients as a continuum of diseases rather than a single disease contributes to the challenges of diagnosis and treatment. The purpose of this analysis was to distinguish and characterize classes of FM within the continuum using data from chronic pain patients.

Methods: FM patients were identified from administrative claims data from the ProCare Systems' network of Michigan pain clinics between January 1999 and February 2015. Read More

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October 2018
8 Reads

Prevalence of fibromyalgia in fourteen Korean tertiary care university hospital pain clinics.

J Pain Res 2018 17;11:2417-2423. Epub 2018 Oct 17.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea,

Purpose: We aimed to investigate the prevalence of fibromyalgia (FM) in patients who visited outpatient pain clinics in Korea, using the modified 2010 American College of Rheumatology (ACR) criteria and to evaluate comorbid conditions that may be associated with FM.

Patients And Methods: Outpatients, aged ≥18 years, who first visited pain clinics at any of the 14 tertiary care university hospitals, were recruited for this study. Modified 2010 ACR criteria were used to diagnose FM. Read More

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October 2018
5 Reads

Is aerobic exercise training beneficial for adults with fibromyalgia? - A Cochrane Review summary with commentary.

Am J Phys Med Rehabil 2018 Nov 12. Epub 2018 Nov 12.

From the Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, Medical faculty of the University of Munich, Germany.

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November 2018
3 Reads

The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: a water PET and EEG imaging study.

BMC Neurol 2018 Nov 12;18(1):191. Epub 2018 Nov 12.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas, USA.

Background: Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed as an effective potential treatment for fibromyalgia-related pain. The aim of this study is to unravel the neural mechanism behind occipital nerve stimulation's ability to suppress pain in fibromyalgia patients. Read More

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November 2018
4 Reads

Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study.

Clin Exp Rheumatol 2018 Oct 30. Epub 2018 Oct 30.

Department of Orthopaedics, Hasharon Hospital, Rabin Medical Center affiliated with Tel Aviv University Sackler School of Medicine, Petah Tikwa, Israel.

Objectives: Low back pain (LBP) occurs in many patients with fibromyalgia (FM). The current study aimed to assess the possible pain and function amelioration associated with medical cannabis therapy (MCT) in this setting.

Methods: 31 patients were involved in an observational cross-over study. Read More

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October 2018
1 Read

Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia.

Biol Res Nurs 2018 Nov 11:1099800418811634. Epub 2018 Nov 11.

1 Department of Physiology, Neuroimmunophysiology and Chrononutrition Research Group, Faculty of Science, University of Extremadura, Badajoz, Spain.

Background:: Mood disturbances are implicated in the pathogenesis of fibromyalgia. The aim of this study was to assess the effect of different doses of melatonin on quality of life, mood status, pain, anxiety, and urinary cortisol levels in patients with fibromyalgia.

Methods:: After a 10-day baseline period for the collection of data about participants' initial status, participants took different doses of melatonin for 10 consecutive days each, with placebo given during the 10 days either before or between melatonin doses. Read More

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November 2018
6 Reads

A 49-Year-Old Man with Debilitating Aches and Pains and a Mysterious Culprit.

Arthritis Care Res (Hoboken) 2018 Nov 10. Epub 2018 Nov 10.

Department of Medicine, Division of Rheumatology, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon.

The patient reported pain that started insidiously in his feet and gradually progressed proximally from the lower extremities to the pelvis, spine and chest. He described it as dull and aching, constant and exacerbated by minimal movement and even inspiration. He complained of frequent severe muscle spasms, cramps, progressive weakness and difficulty with ambulation leading to the use of a wheelchair. Read More

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November 2018
2 Reads

Evaluation of the performance of extreme patient-reported outcomes as surrogate markers for fibromyalgia in axial spondyloarthritis.

Rheumatol Int 2018 Nov 9. Epub 2018 Nov 9.

Rheumatology Department, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France.

Objectives: The aim of the study is to evaluate the performance of extreme patient-reported outcomes (PRO) against definitions of fibromyalgia (FM) in patients with axial spondyloarthritis (axSpA).

Methods: Ancillary analysis of the Predict-SpA trial, an observational study of axSpA patients receiving TNF-α inhibitor, was performed. 'Extreme PRO' was defined as a score ≥ 8 on three out of the first five Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions (scored 0-10). Read More

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November 2018
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Volitional limbic neuromodulation exerts a beneficial clinical effect on Fibromyalgia.

Neuroimage 2018 Nov 5;186:758-770. Epub 2018 Nov 5.

Sagol Brain Institute, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel; School of Psychological Sciences, Tel Aviv University, Tel-Aviv, Israel. Electronic address:

Volitional neural modulation using neurofeedback has been indicated as a potential treatment for chronic conditions that involve peripheral and central neural dysregulation. Here we utilized neurofeedback in patients suffering from Fibromyalgia - a chronic pain syndrome that involves sleep disturbance and emotion dysregulation. These ancillary symptoms, which have an amplificating effect on pain, are known to be mediated by heightened limbic activity. Read More

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November 2018
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Neurodevelopmental disorders associated with juvenile fibromyalgia.

Pediatr Int 2018 Nov 8;60(11):1034-1035. Epub 2018 Nov 8.

Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.

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November 2018
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The Impact of Fibromyalgia in Spondyloarthritis: From Classification Criteria to Outcome Measures.

Front Med (Lausanne) 2018 24;5:290. Epub 2018 Oct 24.

Rheumazentrum Ruhrgebiet Herne, Ruhr University of Bochum, Bochum, Germany.

The term spondyloarthritis (SpA) encompasses a broad clinical spectrum characterized by chronic inflammatory conditions affecting the sacroiliac joints, the spine but also peripheral joints and tendons and being additionally associated with the involvement of organs, such as bowel, eye and skin (1). Musculoskeletal pain is a key symptom in SpA. However, although low back pain and/or joint pain are characteristic for SpA, undifferentiated pain at different enthesial sites may also be a concomitant or even the first clinical presentation in some patients (2). Read More

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October 2018
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