Search Our Scientific Publications & Authors

Neuroimage Clin 2019 Apr 8;23:101817. Epub 2019 Apr 8.

Departamento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Objectives: Fibromyalgia (FM) is a generalized chronic pain syndrome of unknown aetiology. Although FM patients frequently complain of cognitive dysfunction, this is one of the least studied symptoms. Research on brain activity associated with the perceived cognitive impairment is particularly scarce. Read More

Clin Case Rep 2019 Apr 19;7(4):680-685. Epub 2019 Feb 19.

Internal Medicine Residency Program Brookwood Baptist Health Birmingham Alabama.

Hypermobile type Ehlers-Danlos syndrome (hEDS) is an underdiagnosed connective tissue disorder characterized by generalized joint hypermobility, chronic fatigue, widespread joints pain, and impaired quality of life. Here, we reported the first hEDS complicated by hypogammaglobulinemia. New insights into classification, diagnosis, and proper management of hEDS are also reviewed. Read More

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Başkent University School of Medicine, Psychiatry Department, Konya, Turkey.

Objective: Fibromyalgia (FM) patients have higher rates of depression and anxiety disorders than healthy controls. Affective temperament features are subclinical manifestations of mood disorders. Our aim was to evaluate the affective temperaments of FM patients and investigate their association with depression and anxiety levels and clinical findings. Read More

Clin J Pain 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Psychology, National Distance Education University (UNED), Madrid, Spain.

Objectives: Widespread pain is important for the diagnosis of fibromyalgia (FM). For this purpose, the sum of pain regions obtained from a topographical distribution has been used to compute a widespread pain index (WPI), but there is no empirical basis for choosing the regions. The aim of this study was to find an empirical distribution of the pain regions. Read More

Clin Neurol Neurosurg 2019 Apr 9;181:54-57. Epub 2019 Apr 9.

Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, Turkey.

Objectives: The aim of this study is to evaluate the efficacy of greater occipital nerve (GON) blockage in patients with migraine and fibromyalgia (FM) comorbidity.

Patients And Method: 20 patients who were diagnosed as FM according to 2010 American College of Rheumatology (ACR) diagnostic criteria and migraine according to International Classification of Headache Disorers II criteria and did not recieve any medication or GON block for both disorders were included for the study. GON blocks were repeated every week in the first month and repeated montly for the following 2 months. Read More

Aten Primaria 2019 Apr 11. Epub 2019 Apr 11.

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, España; Escuela Andaluza de Salud Pública, Granada, España; Instituto de Investigación Biosanitaria de Granada, Granada, España.

Objective: To measure the impact of the peer-led training for chronic patients on their health status and behaviors.

Design: Descriptive, transversal pretest and posttest quantitative approach.

Placement: Andalusia. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 28. Epub 2019 Feb 28.

Unit of Orofacial Pain and Temporomandibular Dysfunction, University Dental Clinic, Monastir, Tunisia.

Objective: Fibromyalgia (FM) is characterized by bodywide diffuse and chronic musculoskeletal pain, which, in some patients, can include pain in the masticatory muscles and temporomandibular joints; those patients are defined as having temporomandibular disorders (TMDs). The purpose of this systematic review is to study the association between FM and TMD, as well as the prevalence and characteristics of TMD in patients with FM or the features and prevalence of FM in patients with TMD.

Study Design: Our bibliographic search was conducted from January 1, 2005, to May 31, 2018, in the MEDLINE database by using its free search engine PubMed and the keywords "fibromyalgia," "temporomandibular joint disorder," and "orofacial pain. Read More

Pain Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle, Washington, USA.

Objective: Fibromyalgia patients face particular challenges in building relationships with health care providers. In this study, we examine, from patients' perspectives, factors that influence the formation of effective patient-provider relationships.

Design: This research employed a qualitative approach to analyze data collected from a study that employed semistructured interviews. Read More

Mol Divers 2019 Apr 12. Epub 2019 Apr 12.

Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran.

MgCl has been reported to be a versatile reagent especially as a Lewis acid catalyst in a variety of organic transformations including the preparation of heterocyclic compounds, the protection of functional groups and condensation reaction. Also the use of MgCl in the preparation of metallic magnesium and the application of magnesium chloride in biochemistry such as anesthetic for cephalopods, the separation of serum high-density lipoprotein, effect of MgCl on rabbit bronchial smooth muscle, antimicrobial properties of magnesium chloride and effect of MgCl on the quality of life for patients with fibromyalgia have been reported. Therefore, in this article the use of MgCl in organic chemistry and biochemistry is reviewed. Read More

J Clin Med 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Healthcare expenditures in the United States are growing at an alarming level with the Centers for Medicare and Medicaid Services (CMS) projecting that they will reach $5.7 trillion per year by 2026. Inflammatory diseases and related syndromes are growing in prevalence among Western societies. Read More

Int J Gynaecol Obstet 2019 Apr 11. Epub 2019 Apr 11.

Department of Gynecology, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Barcelona, Spain.

Objective: To estimate the prevalence of fibromyalgia among women with endometriosis and analyze the effect of fibromyalgia on health-related quality of life (HRQoL).

Methods: An observational case-control study conducted at a tertiary hospital in Barcelona between April 2015 and March 2017 among women with deep infiltrating endometriosis (DIE; n=80), women with superficial endometriosis or ovarian endometrioma (non-DIE; n=76), and control women without endometriosis (n=73). Fibromyalgia was assessed via the London Fibromyalgia Epidemiological Study Screening Questionnaire (LFESSQ). Read More

Clin Pract Epidemiol Ment Health 2018 31;14:263. Epub 2018 Oct 31.

Department of Surgical, Medical and Molecular Pathology, Critical and Care Medicine, University of Pisa, Pisa, Italy.

Int J Environ Res Public Health 2019 Apr 8;16(7). Epub 2019 Apr 8.

Independent researcher, Sint-Laurentiusstraat 87, 9700 Oudenaarde, Belgium.

The classification of medically unexplained symptoms (MUS) could have negative consequences for patients with functional somatic syndromes (FSS). By grouping related but distinct syndromes into one label, the MUS classification fails to inform clinicians about their patients' health condition. In research settings, the MUS classification makes patient samples more heterogeneous, obstructing research into the underlying pathology of FSS. Read More

Ann Transl Med 2019 Feb;7(4):64

Department of Orthopaedic Surgery, Lenox Hill Hospital, Northwell Health, New York, NY, USA.

Background: Fibromyalgia is a disease primarily characterized by chronic widespread pain and associated symptoms of fatigue, mild cognitive impairment, and sleep disturbance. The condition affects 1% to 6% of the general population in the United States and is more commonly diagnosed in women (2:1 ratio). There is evidence to suggest that fibromyalgia patients may be more at risk of postoperative complications. Read More

Reg Anesth Pain Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Anesthesiology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Background: Studies have found that diffuse pain, indicative of central sensitization, portends poor interventional outcomes. Multiple chemical sensitivities are associated with signs of central sensitization. We sought to prospectively determine whether hypersensitivity reactions (HR) were associated with epidural steroid injection (ESI) outcomes. Read More

BMJ Open 2019 Apr 8;9(4):e026581. Epub 2019 Apr 8.

School of Medicine, China Medical University, Taichung, Taiwan.

Objective: Fibromyalgia (FM) and migraine are common pain disorders that tend to coexist. This study determined whether these two conditions exhibited any mutual influences.

Setting: Cohort study. Read More

Pain Med 2019 Apr 8. Epub 2019 Apr 8.

Independent Global Pharmaceutical Physician, UK.

J Psychosom Res 2019 Apr 2. Epub 2019 Apr 2.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

Objective: Epidemiological research in functional somatic disorders such as irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, and bodily distress syndrome and related conditions such as health (illness) anxiety is often based on self-reported questionnaires or layman interviews. This study presents and describes the Research Interview for Functional somatic Disorders (RIFD) and provides first data regarding RIFD's ability to identify cases with functional somatic disorders and health anxiety in a two-phase design following self-reported symptom questionnaires.

Methods: RIFD was performed by phone by trained family physicians on a stratified subsample of 1590 adults from a Danish general population cohort (n = 7493). Read More

Somatosens Mot Res 2019 Apr 8:1-7. Epub 2019 Apr 8.

d Physical Medicine and Rehabilitation , Izmir Katip Celebi Universitesi , Izmir , Turkey.

Objective: To investigate effectiveness of two different high-frequency repetitive transcranial magnetic stimulation (rTMS) protocols on pain, fatigue, quality of life (QoL) and depression in female patients with fibromyalgia.

Methods: Thirty patients were randomized into three groups. Fifteen sessions of 10 Hz (90% resting motor threshold-RMT, 1200 pulses) rTMS were applied to left primary motor cortex and left dorsolateral prefrontal cortex (DLPFC) in Group M1 (n:10) and Group DLPFC (n:10), respectively. Read More

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

DOIM-Rheum, MSC 10 5550, University of New Mexico Health Sciences Center, 5th FL ACC, Albuquerque, NM 87131, United States.

Objective: The goal of this study was to determine the characteristics of Behçet's disease (BD) in the American Southwest.

Material And Methods: This was a cross-sectional study of BD patients clinically encountered during a 2-year period. All subjects fulfilled the International Study Group criteria (ISG) or International Criteria for Behcet's Disease (ICBD). Read More

Clin J Pain 2019 Apr 3. Epub 2019 Apr 3.

Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.

Objectives: Chronic postsurgical knee-pain (CPSP) is a burden for approx. 20% of the patients following total knee replacement (TKR). Presurgical pain intensities have consistently been found associated with CPSP and it is suggested that e. Read More

Evid Based Complement Alternat Med 2019 4;2019:9684649. Epub 2019 Mar 4.

Department of Computer Engineering, Engineering Faculty of Başkent University, Ankara, Turkey.

. To evaluate the effects of acupuncture and transcutaneous electric nerve stimulation (TENS) applications on the quantitative electroencephalography (qEEG) changes and to evaluate their therapeutic effects in patients with fibromyalgia syndrome (FMS). The study included 42 patients with FMS and 21 healthy volunteers. Read More

Front Psychiatry 2019 20;10:141. Epub 2019 Mar 20.

Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.

The beneficial effects of exercise training on depressive symptoms are well-established. In the past years, more research attention has been drawn to the specific effects of exercise training on depressive symptoms in somatically ill patients. This reviews aims at providing a comprehensive overview of the current findings and evidence of exercise interventions in somatic disorders to improve depressive symptoms. Read More

JMIR Med Inform 2019 Apr 4;7(2):e12561. Epub 2019 Apr 4.

Eli Lilly and Company, Indianapolis, IN, United States.

Background: Medication nonadherence can compound into severe medical problems for patients. Identifying patients who are likely to become nonadherent may help reduce these problems. Data-driven machine learning models can predict medication adherence by using selected indicators from patients' past health records. Read More

Neurourol Urodyn 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Aims: The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Read More

Nurs Res 2019 Apr 1. Epub 2019 Apr 1.

Associate Professor, Instituto de Investigación Biosanitaria Granada (IBIS, Granada), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain PhD Candidate, Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Spain PhD Candidate, Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Spain Associate Professor, Department of Health Sciences, University of Jaén, Paraje Las Lagunillas, Jaén, Spain Associate Professor, Department of Cell Biology, University of Granada, Granada, Spain Professor, Instituto de Investigación Biosanitaria Granada (IBIS, Granada), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain Instituto de Investigación Biosanitaria Granada, Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Spain.

Background: There is very little scientific literature on the potential relationships between modifiable factors, including body composition, dietary pattern and physical activity (PA), and bone status in patients with fibromyalgia: A musculoskeletal condition characterized by chronic, widespread pain that is often accompanied by a broad spectrum of symptoms.

Objectives: To investigate the impact of body composition parameters, adherence to the Mediterranean diet (Med Diet), and PA on bone health in a population of premenopausal and postmenopausal women with fibromyalgia syndrome (FMS).

Methods: Ninety-five women diagnosed with FMS were included in this cross-sectional study. Read More

Complement Ther Med 2019 Apr 23;43:181-187. Epub 2019 Jan 23.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Aims: A number of studies have examined the beneficial effects of Coenzyme Q10 (CoQ10) on fatigue in different population, but the findings have been inconclusive. Herein, we systematically reviewed available interventional studies to elucidate the overall effects of CoQ10 supplementation on fatigue among adolescent and adult population.

Methods: PubMed, Cochrane's library, Science direct, Scopus, Google scholar and ISI web of science databases were searched for all available literature until April 2018 for studies assessing the effects of CoQ10 supplementation on fatigue. Read More

Int J Mol Sci 2019 Mar 27;20(7). Epub 2019 Mar 27.

Dipartimento di scienze Biomediche, Sperimentali e Cliniche "M. Serio", Università degli studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy.

In skeletal muscle, adiponectin has varied and pleiotropic functions, ranging from metabolic, anti-inflammatory, insulin-sensitizing to regenerative roles. Despite the important functions exerted by adiponectin, the study of the hormone in myopathies is still marginal. Myopathies include inherited and non-inherited/acquired neuromuscular pathologies characterized by muscular degeneration and weakness. Read More

Acta Medica (Hradec Kralove) 2019 ;62(1):12-18

Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.

Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Read More

J Neuroinflammation 2019 Mar 30;16(1):67. Epub 2019 Mar 30.

Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial activation in the lumbar spinal cord and pain behavior without peripheral tissue damage and/or inflammation. The present study addressed the mechanism underlying the association between pain and chronic stress using this rat model. Read More

Arthritis Care Res (Hoboken) 2019 Mar 30. Epub 2019 Mar 30.

University of New Mexico Health Sciences Center, Project ECHO, Albuquerque, New Mexico, United States.

Objective: Demonstrate the effectiveness of Project ECHO (Extension for Community Healthcare Outcomes) in educating primary care clinicians (PCCs) to provide best practice rheumatology care to patients in under-resourced communities in New Mexico (NM).

Methods: Attendee data for weekly teleECHO sessions, lectures, grand rounds, and mini-residency trainings were evaluated from June 2006 to June 2014. Participant feedback was evaluated from January 2009 to December 2014, when the program was approved for continuing medical education (CME) credits. Read More

Clin Psychol Psychother 2019 Mar 29. Epub 2019 Mar 29.

Kingston University, Kingston upon Thames, UK.

Anxiety and depression add to the burden of Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and Type 1 Diabetes Mellitus (T1DM). Metacognitions play a role in this distress. The Metacognitions about Symptoms Control Scale (MaSCS) measures metacognitive beliefs regarding symptoms but has weaknesses. Read More

Clin Rheumatol 2019 Mar 29. Epub 2019 Mar 29.

Albert Einstein College of Medicine, Bronx, NY, USA.

To investigate specific disease patterns in the rheumatic manifestations associated with autoimmune thyroid disease (AITD) through a systematic literature review. We performed a systematic review using the Medline OVID, PubMed, EMBASE, and Web of Science databases through May 2018 for experimental and observational studies that explored the association of AITD with degenerative joint disease (DJD), osteoarthritis (OA), chronic widespread pain (CWP) and fibromyalgia syndrome (FMS), and seronegative inflammatory arthritis (IA). A total of 2132 articles were identified. Read More

Arthritis Res Ther 2019 Mar 28;21(1):83. Epub 2019 Mar 28.

EA 4708 I3MTO Laboratory, University Orleans, 45067, Orleans, France.

Obesity is associated with numerous comorbidities including some rheumatic conditions. Through adipose-derived inflammation, obesity has been shown to induce increased initiation, progression, and worse responses on outcomes of rheumatic diseases. Bariatric surgery is being increasingly used thanks to its positive effects on major comorbidities such as type 2 diabetes mellitus and hypertension. Read More

Psychosom Med 2019 Mar 26. Epub 2019 Mar 26.

Health Psychology, Department of Psychology and Educational Sciences, University of Leuven, Belgium.

Objective: Patients with functional somatic syndromes (FSS) show reduced correspondence between induced physiological changes and self-reported symptoms in a rebreathing paradigm, as well as elevated symptoms unrelated to physiological changes after induction of negative affective states in an affective picture viewing paradigm. Detailed results of both paradigms separately were published elsewhere. The main goal of the current report is to describe the relationship between the responses to these two paradigms measuring distortions in symptom perception in a well-described sample of patients with fibromyalgia and/or chronic fatigue syndrome (CFS). Read More

J Sleep Res 2019 Mar 28:e12843. Epub 2019 Mar 28.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

Pain severity and sleep are associated with cognitive performance in patients with fibromyalgia. This study examined whether sleep mediates the relationships of pain severity with psychomotor vigilance and attention in patients with fibromyalgia by analysing 80 patients with fibromyalgia. Cognitive performance, pain severity and sleep parameters were determined using the Psychomotor Vigilance Task, Brief Pain Inventory-Short Form and sleep diaries of seven consecutive nights, respectively. Read More

Metabolomics 2019 Mar 27;15(4):54. Epub 2019 Mar 27.

Faculty of Natural and Agricultural Sciences, Centre for Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom, South Africa.

Introduction: Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Previous analyses of untargeted metabolomics data indicated altered metabolic profile in FMS patients.

Objectives: We report a semi-targeted explorative metabolomics study on the urinary metabolite profile of FMS patients; exploring the potential of urinary metabolite information to augment existing medical diagnosis. Read More

Clin Nurs Res 2019 Mar 27:1054773819838679. Epub 2019 Mar 27.

1 Universidad Rey Juan Carlos, Madrid, Spain.

Fibromyalgia, chronic fatigue syndrome/myalgic encephalomyelitis, and multiple chemical sensitivity can be considered contested illnesses. The questioning of the status of these conditions as real diseases reduces feelings of legitimacy in those affected. The purpose of this study was to analyze subjectivity construction processes in people with these diseases. Read More

Am J Hosp Palliat Care 2019 Mar 27:1049909119838974. Epub 2019 Mar 27.

2 Hospice and Palliative Medicine, Ballad Health System, Kingsport, TN, USA.

Pain can have a devastating effect on the quality of life of patients in palliative medicine. Thus far, majority of research has been centered on opioid-based pain management, with a limited empirical evidence for the use of nonopioid medications in palliative care. However, opioid and nonopioid medications such as nonsteroidal anti-inflammatory drugs have their limitations in the clinical use due to risk of adverse effects, therefore, there is a need for more research to be directed to finding an alternative approach to pain management in comfort care setting. Read More

Biol Res Nurs 2019 May 27;21(3):272-278. Epub 2019 Mar 27.

4 Department of Physical Therapy, Faculty of Health Science, Instituto de Investigación Biosanitaria Granada, University of Granada, Granada, Spain.

This study aimed to evaluate the impact of fibromyalgia syndrome (FMS) on bone mass assessed by calcaneal quantitative ultrasound (QUS) in pre- and postmenopausal women and determine whether there are associations between bone status and pressure pain thresholds (PPTs), tender point counts (TPCs), self-reported global pain, or disease severity. Ninety-five women with a diagnosis of FMS and 108 healthy controls matched on menopause status were included in this cross-sectional study. PPT and TPC were measured by algometry pressure. Read More

Front Psychol 2019 12;10:480. Epub 2019 Mar 12.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

The assessment of pain and its impact on quality of life is central to the evaluation of chronic pain syndromes. However, most available tools focus on the nociceptive experience of pain, and at best only consider the occurrence of anxious, depressive, or cognitive problems. Here is a new questionnaire aimed at measuring the multifaceted impact of pain in chronic pain syndromes, the Bodily and Emotional pErception of Pain (BEEP). Read More

J Drugs Dermatol 2019 Mar;18(3):235-238

Low-dose naltrexone (LDN) has been successfully studied as an immunomodulatory and anti-inflammatory therapy in a wide range of conditions including Crohn’s disease, fibromyalgia, major depressive disorder, cancer, chronic regional pain syndrome, Charcot-Marie-Tooth, and multiple sclerosis.1-5 Recently, off label LDN has been shown to improve dermatologic conditions such as systemic sclerosis, Hailey-Hailey Disease, lichen planopilaris, and guttate psoriasis.6-9 In this article, we examine the existing evidence for use of LDN in skin disease and discuss its potential application in the treatment of atopic dermatitis (AD). Read More

Pain Med 2019 Mar 25. Epub 2019 Mar 25.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Background: Low-level laser therapy (LLLT) is widely used in pain control in the field of physical medicine and rehabilitation and is effective for fibromyalgia pain. However, its analgesic mechanism remains unknown. A possible mechanism for the effect of LLLT on fibromyalgia pain is via the antinociceptive signaling of substance P in muscle nociceptors, although the neuropeptide has been known as a neurotransmitter to facilitate pain signals in the spinal cord. Read More

JAMA Intern Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, University of South Carolina School of Medicine, Columbia.

Background: The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain. For gabapentin, the only pain-related indication approved by the US Food and Drug Administration (FDA) is postherpetic neuralgia. For pregabalin, FDA-approved indications related to pain are limited to postherpetic neuralgia, neuropathic pain associated with diabetic neuropathy or spinal cord injury, and fibromyalgia. Read More

PM R 2019 Mar 22. Epub 2019 Mar 22.

Master student in Human Movement Sciences, Health and Sports Science Center - CEFID / Santa Catarina State University - UDESC, Florianópolis, SC, Brazil.

Mayo Clin Proc Innov Qual Outcomes 2019 Mar 26;3(1):78-85. Epub 2019 Feb 26.

Department of Anesthesiology, Pain Division, Mayo Clinic, Rochester, MN.

Objective: To evaluate the association between smoking and cognitive function in patients with fibromyalgia.

Patients And Methods: We surveyed 668 patients with fibromyalgia from May 1, 2012 through November 30, 2013 at a major tertiary referral center. Patients were categorized by smoking status. Read More

CNS Spectr 2019 Mar 21:1-4. Epub 2019 Mar 21.

Department of Neurosciences,Deutsches Hospital,Buenos Aires,Argentine Republic.

Background: Fibromyalgia (FM) is a chronic pain syndrome with a controversial etiopathogenesis. Patients with FM usually complain of cognitive symptoms, which are described as "fibrofog." These cognitive complaints might be caused partially by dissociative disorders (DD). Read More

Pharmaceutics 2019 Mar 18;11(3). Epub 2019 Mar 18.

School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.

Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are diseases of unknown etiology presenting complex and often overlapping symptomatology. Despite promising advances on the study of miRNomes of these diseases, no validated molecular diagnostic biomarker yet exists. Since FM and ME/CFS patient treatments commonly include polypharmacy, it is of concern that biomarker miRNAs are masked by drug interactions. Read More

Acta Biomed 2019 Jan 23;90(1):134-148. Epub 2019 Jan 23.

Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy.

Juvenile fibromyalgia syndrome (JFMS) is a chronic condition characterized by symptoms of chronic diffuse musculoskeletal pain and multiple painful tender points on palpation. It is often accompanied by fatigue, disorders of sleep, chronic headaches, irritable bowel syndrome, and subjective soft tissue swelling. The complexity of the presenting clinical picture in JPFS has not been sufficiently defined in the literature. Read More