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Integr Med Res 2020 Dec 25;9(4):100416. Epub 2020 Apr 25.

Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, United States.

Background: Some of the most debilitating symptoms of fibromyalgia (FM) include widespread chronic pain, sleep disturbances, chronic fatigue, anxiety, and depression. Yet, there is a lack of effective self-management exercise interventions capable of alleviating FM symptoms. The objective of this study is to examine the efficacy of a 10-week daily Qigong, a mind-body intervention program, on FM symptoms. Read More

Neurosci Lett 2020 May 23:135058. Epub 2020 May 23.

The Department of Biological Chemistry and The Edmond and Lilly Safra Center for Brain Sciences, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address:

Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus, presenting patients and caregivers with a substantial disease burden. Emerging mechanisms which are underlying diabetes may provide novel pathways to understand diabetic polyneuropathy (DPN). Specifically, non-coding RNA molecules consisting of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are implicated in the biological processes underlying DPN, and may link it to clinical spheres such as other metabolic and neural pathologies. Read More

Musculoskeletal Care 2020 May 26. Epub 2020 May 26.

Centre for Health and Clinical Research, Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK.

Background: Fibromyalgia (FM) is a complex long-term condition associated with pain, fatigue and concentration difficulties. There is limited robust evidence for the effectiveness of pharmacological treatments for FM, with current guidelines recommending nonpharmacological interventions. The clinically developed Fibromyalgia Self-Management Programme (FSMP) is a nonpharmacological, multidisciplinary education group intervention. Read More

Pain Med 2020 May 25. Epub 2020 May 25.

Department of Psychiatry and Human Behavior, University of California, Irvine School of Medicine, Irvine, California, USA.

Objective: Emotional awareness and expression therapy (EAET) emphasizes the importance of the central nervous system and emotional processing in the etiology and treatment of chronic pain. Prior trials suggest EAET can substantially reduce pain; however, only one has compared EAET with an established alternative, demonstrating some small advantages over cognitive behavioral therapy (CBT) for fibromyalgia. The current trial compared EAET with CBT in older, predominately male, ethnically diverse veterans with chronic musculoskeletal pain. Read More

Eur J Pharmacol 2020 May 20:173194. Epub 2020 May 20.

Drug Discovery Res, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.

Exogenous cannabinoid receptor agonists are clinically effective for treating chronic pain but frequently cause side effects in the central nervous system. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide, an endogenous cannabinoid agonist. 3-Pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477) is a potent and selective FAAH inhibitor that is orally active and able to increase the brain anandamide level and is effective in rat models of neuropathic and osteoarthritis pain without causing motor coordination deficits. Read More

S D Med 2020 Apr;73(4):178-180

Regional Health Neurology and Rehabilitation, Rapid City, South Dakota.

In this report, we present a case of acquired copper deficiency which initially presented as progressive pain and numbness in the patient's lower extremities. The acquired copper deficiency is attributed to a previous bariatric surgery exacerbated by zinc toxicity. A 42-year-old female with a past medical history of type 2 diabetes mellitus, anemia, hypertension, bipolar disorder, attention deficit disorder, pulmonary embolus, fibromyalgia, migraine headaches, and chronic pain as well as a remote past surgical history of gastric bypass procedure presented with progressive pain and numbness in her lower extremities. Read More

Brain Sci 2020 May 18;10(5). Epub 2020 May 18.

Center for Social and Affective Neuroscience, Linköping University, 58185 Linköping, Sweden.

Social touch is important for interpersonal interaction. Gentle touch and slow brushing are typically perceived as pleasant, the degree of pleasantness is linked to the activity of the C-tactile (CT) fibers, a class of unmyelinated nerves in the skin. The inability to experience pleasure in general is called anhedonia, a common phenomenon in the chronic pain condition fibromyalgia. Read More

Arthroscopy 2020 May 19. Epub 2020 May 19.

University of Iowa Hospitals and Clinics, Department of Orthopedics and Rehabilitation, Iowa City, IA-52242.

Purpose: The purpose of this study was to (1) report the frequency of postoperative opioid prescriptions following elbow arthroscopy, (2) evaluate if filling opioid prescriptions preoperatively increased risk of requiring more opioid prescriptions after surgery, and (3) determine patient factors associated with postoperative opioid prescription needs.

Methods: A national claims-based database was queried for patients undergoing primary elbow arthroscopy. Patients with prior total elbow arthroplasty or septic arthritis of the elbow were excluded. Read More

Open Access Rheumatol 2020 5;12:55-63. Epub 2020 May 5.

Rheumatology, Rehabilitation and Physical Medicine Department, Benha University, Benha, Egypt.

Background: Knee osteoarthritis (OA) is a painful condition with peripheral and central pain transmission. Fibromyalgia (FM) is the role model of central sensitization of pain perception.

Aim: To assess the frequency of FM in knee OA patients and evaluate the impact of FM on mental health and the quality of life in knee OA patients. Read More

Arthroscopy 2020 May 10. Epub 2020 May 10.

Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Purpose: To identify risk factors for opioid consumption after arthroscopic meniscectomy using a large national database.

Methods: Patients undergoing primary arthroscopic meniscectomy from 2007-2016 were retrospectively accessed from the Humana database. Patients were categorized as those who filled opioid prescriptions within 3 months (OU), within 1 month (A-OU), between 1 to 3 months (C-OU), and never filled opioid prescriptions (N-OU) before surgery. Read More

Physiother Theory Pract 2020 May 21:1-10. Epub 2020 May 21.

Physical Therapy Department, Universidade Cidade de São Paulo, Sao Paulo, Brazil.

: Psychological processes can play an important role in the expression and clinical impact of fibromyalgia.: To investigate the association between the severity of pain and disability and psychological factors in patients with fibromyalgia.: The following outcomes were assessed in 104 patients with fibromyalgia: pain intensity, using the Pain Numerical Rating Scale; disability, using the Patient-Specific Functional Scale; depression, using the Beck Depression Scale; anxiety, using the State-Trait Anxiety Inventory; kinesiophobia, using the Tampa Scale for Kinesiophobia; pain catastrophizing, using the Pain Catastrophizing Scale; beliefs and attitudes toward pain, using the Survey of Pain Attitudes; and the occurrence of abuse during some stage of life. Read More

Harefuah 2020 May;159(5):343-348

Department of Medicine C, Laniado Hospital, Netanya, Israel.

Introduction: Medical cannabis (MC) is becoming more and more popular among patients with chronic pain syndromes. In this study we evaluated the characteristics of MC use among patients with fibromyalgia.

Methods: All patients with fibromyalgia who were followed up at Laniado Hospital in Netanya and at the Nazareth Hospital in Nazareth, in addition to all patients followed at the different health service organizations by the first author were located and contacted regarding a large number of parameters. Read More

J Am Board Fam Med 2020 May-Jun;33(3):386-396

From Unitat de Fibromiàlgia, Servei de Reumatologia, ICEMEQ, Hospital Clínic de Barcelona, Barcelona, Spain (BO, AC, EG, AA); Unitat de Fibromiàlgia, Servei de Psiquiatria i Psicologia, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain (XT); Joan XXIII University Hospital, Tarragona, Spain (ES); Unidad de Gestión Clínica Bajo Andarax, Almería, Spain (JV); Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain (XC).

Objective: Burnout among physicians has increased, affecting not only doctors but also the quality of patient care. Treating challenging disorders, such as fibromyalgia, may increase the risk of feeling burned out. Health care of fibromyalgia patients is increasingly being assigned to family physicians. Read More

J Headache Pain 2020 May 19;21(1):54. Epub 2020 May 19.

Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, No. 201, Sec. 2, Shi-Pai Road, Bei-Tou District, Taipei City, Taiwan, 11217.

Background: Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among different indications in Asia have rarely been explored.

Methods: This was a population-based retrospective cohort study based on the National Health Insurance Research Database in Taiwan. Read More

Brain Sci 2020 May 15;10(5). Epub 2020 May 15.

School of BME and u-HARC, Inje University, Gimhae, Gyeongnam 50834, Korea.

Milnacipran is a reuptake inhibitor of both serotonin and noradrenaline, used in the treatment of fibromyalgia with severe depression. However, few studies have been conducted on the efficacies of milnacipran drug on the functional connectivity of the neural network. The authors aimed to find the correlation between the drug efficacy and the changes in neural network in fibromyalgia patients. Read More

J Opioid Manag 2020 May/Jun;16(3):179-188

VA Salt Lake City Health Care System, Salt Lake City, Utah.

Objective: As part of the evaluation of the Whole Health Primary Care Pain Education and Opioid Monitoring Program (PC-POP), we compared demographic and health characteristics between participants and nonparticipants drawn from the same defined population.

Design/methods: Retrospective chart review comparing participants and nonparticipants in terms of two categories of variables: (1) demographic characteristics and (2) physical/mental health characteristics.

Setting: VA Primary Care. Read More

Somatosens Mot Res 2020 May 18:1-8. Epub 2020 May 18.

Centre d'Evaluation et de Traitement de la Douleur (CETD), Centre hospitalier de Valenciennes, Valenciennes, France.

Fibromyalgia (FM) is a chronic pain syndrome, characterised by several symptoms. One of the most prevalent symptoms in FM is balance impairment that compromise the autonomy, function and performance status of patients. The main objective of the present study was to evaluate the effect of sensory stimulation provided by the use of a low additional thickness of 0. Read More

J Health Psychol 2020 May 18:1359105320918322. Epub 2020 May 18.

University of California, USA.

This feasibility study employed a new approach to capturing pain disclosure in face-to-face and online interactions, using a newly developed tool. In Study 1, 13 rheumatoid arthritis and 52 breast cancer patients wore the Electronically Activated Recorder to acoustically sample participants' natural conversations. Study 2 obtained data from two publicly available online social networks: fibromyalgia (343,439 posts) and rheumatoid arthritis (12,430 posts). Read More

J Crohns Colitis 2020 May 15. Epub 2020 May 15.

Rheumatology Unit, IRCCS Sacro Cuore Don Calabria, Negrar, Italy.

Background And Aimes: Both peripheral and axial spondyloarthritis (SpA) occurs in inflammatory bowel disease (IBD) and represents the commonest extra-intestinal manifestation. We aimed to develop an easy and quick questionnaire through psycometric analysis to identify peripheral and axial SpA in IBD patients within an integrated combined multidisciplinary rheumatological-gastroenterology clinic.

Methods: Initially, SpA-IBD experts generated a 42-item list covering SpA manifestations including spinal, articular and entheseal involvement. Read More

Int J Behav Med 2020 May 13. Epub 2020 May 13.

École de psychologie, Pavillon Félix-Antoine-Savard, Université Laval, 2325 rue des Bibliothèques, local 1044, Québec, Québec, G1V 0A6, Canada.

Background: The present study outlines a clinical profile of an ecologically valid population consulting for sleep difficulties at the Sleep Psychology Clinic of the Consultation service of the School of Psychology of Université Laval .

Method: Patients self-report to the sleep clinic. Following a phone screening interview, patients present to the clinic for a semi-structured clinical interview for sleep and psychopathology, which is conducted by psychologists and doctorate psychology students. Read More

Int J Psychiatry Clin Pract 2020 May 13:1-7. Epub 2020 May 13.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

The first aim of this study was to determine the prevalence of childhood and current attention deficit hyperactivity disorder (ADHD) symptoms in patients with fibromyalgia. The second aim is to assess the role of depression and anxiety on the relationship between childhood and adult ADHD symptoms with disease impact in this population. Sixty-four patients with fibromyalgia were compared to matched 58 healthy controls. Read More

Pain Res Manag 2020 27;2020:3586767. Epub 2020 Apr 27.

Faculty of Music, University of Toronto, Toronto, Ontario, Canada.

Ehlers-Danlos syndrome (EDS) is a connective tissue disorder characterized by joint hypermobility and skin extensibility and is often accompanied by chronic pain. Rhythmic sensory stimulation (RSS) can be defined as the stimulation of the senses in a periodic manner within a range of low frequencies. Music plus sound delivered through a vibroacoustic device is a form of RSS and has demonstrated utility in managing pain. Read More

Arch Med Sci 2020 15;16(3):597-602. Epub 2019 Aug 15.

Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.

Introduction: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases. We aimed to clarify the possible aetiology of this disease by using thiol and disulphide levels in patients with fibromyalgia, the basis of which has not yet been clearly elucidated.

Material And Methods: A total of 156 individuals: 86 patients with fibromyalgia and 70 age-matched controls were included in this prospective non-randomised case-control study. Read More

Animals (Basel) 2020 May 9;10(5). Epub 2020 May 9.

Section of Integrative Medicine and Health, Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55901, USA.

Therapy dogs are increasingly being incorporated into numerous clinical settings. However, there are only a handful of studies that have focused on the impact of animal-assisted activity or therapy sessions on the wellbeing of the therapy dogs. Furthermore, these studies show mixed results. Read More

Biomed Chromatogr 2020 May 12:e4883. Epub 2020 May 12.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy Science and Technology of Târgu Mureş, Romania.

Duloxetine (DLX) is a widely used antidepressant drug belonging to the class of selective serotonin and norepinephrine reuptake inhibitors (SNRIs); its efficacy has been demonstrated in the treatment of not only major depressive disorders but also diabetic neuropathic pain, generalized anxiety disorder, fibromyalgia or stress urinary incontinence. It is a chiral substance and is used in therapy in the form of the enantiopure S-DLX which is twice as active as R-DLX. Several methods have been published for the achiral and chiral determination of DLX in pharmaceuticals, biological materials and environmental samples, the majority using liquid chromatography (LC) and capillary electrophoresis (CE) coupled with different detection techniques (UV detection, fluorescence, mass spectrometry). Read More

Urology 2020 May 8. Epub 2020 May 8.

Western New York Urology Associates, Cheektowaga, NY.

Objective: To identify risk factors associated with surgical revision of midurethral sling (MUS) due to mesh extrusion.

Materiald And Methods: This is a case-control study identifying women who underwent primary surgical revision of polypropylene MUS for vaginal mesh extrusion from 2001 to 2016. Cases of surgical revision were compared to a randomly selected control group in a 1:5 ratio. Read More

Neurosci Lett 2020 Jun 5;729:135006. Epub 2020 May 5.

Department of Structural and Functional Biology, State University of Campinas, Rua Monteiro Lobato, 255, Cidade Universitaria Zeferino Vaz, Box 6109, Campinas, SP 13083-865, Brazil. Electronic address:

Recently the voltage-gated sodium (Nav) channels began to be studied as possible targets for analgesic drugs. In addition, specific Nav 1.8 blockers are currently being used to treat some types of chronic pain pathologies such as neuropathies and fibromyalgia. Read More

Eur J Pain 2020 May 7. Epub 2020 May 7.

AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, France.

Background: Fibromyalgia has been associated with various physical and mental disorders. However, these comorbidities need to be quantified in a population-based study.

Method: We compared participants with and without self-reported fibromyalgia to assess (a) The prevalence of self-reported fibromyalgia and its sociodemographic characteristics in a US representative sample, (b) The associations between self-reported fibromyalgia and lifetime and past 12-month mental and physical disorders and (c) The quality of life associated with self-reported fibromyalgia. Read More

Games Health J 2020 May 5. Epub 2020 May 5.

Science Rehabilitation Program, Federal University of Alfenas, Alfenas, Brazil.

Evaluation of the effects of exergames in women with fibromyalgia on the impact of the disease-pain threshold and physical variables-compared to performing stretching exercises. Thirty-five women were enrolled in the study and divided by simple randomization into two treatment groups: the control group ( = 19) and the Wii™ (exergames) group ( = 16). Participants were evaluated using the fibromyalgia impact questionnaire (FIQ), algometry, step tests, cardiopulmonary parameters, and fatigue in the lower limbs. Read More

Pain 2020 May 4. Epub 2020 May 4.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Behavioral studies have demonstrated aberrant safety-processing in fibromyalgia subjects (FMS), and suggested that patients accumulate new potential pain-related threats more effectively than extinguishing no longer relevant ones. The aim of the current study was to investigate the neural correlates of conditioned pain responses and their relationship to emotional distress in FMS (n=67) and healthy controls (HC, n=34). Using functional magnetic resonance imaging (fMRI), we traced conditioned pain responses to an identical moderately painful pressure (P30) depending on whether it was following a green (P30green) or a red (P30red) cue. Read More

Int Rev Psychiatry 2020 May 7:1-9. Epub 2020 May 7.

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.

Neuresthenia has had its popularity waxing and waning over the years. This review article traces the path and trajectory of the concept of this disorder, how it changed and varied over time, to the current times, when it has been almost forgotten and the concept is heading towards oblivion. Although its place in the diagnostic systems is currently in question, neurasthenia is still part of professional conversations and practice. Read More

Rheumatol Int 2020 May 6. Epub 2020 May 6.

Department of Physiotherapy, Speech Therapy and Occupational Therapy, School of Medicine, Faculty of Medicine, University of São Paulo, Cipotanea Street, 51, São Paulo, SP, Brazil.

Background: Fibromyalgia (FM) is characterized by chronic and widespread pain, sleep disturbances, fatigue, psychological distress and morning stiffness. These patients also present symptoms such as depression, sexual dysfunctions and reproductive problems. Sexuality involves several aspects, including pelvic floor functionality, and one question is whether the sexual performance of women with fibromyalgia is associated with pelvic floor function or other characteristics of the disease. Read More

Ocul Surf 2020 May 3. Epub 2020 May 3.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

JMIR Form Res 2020 May 5. Epub 2020 May 5.

L.A. Pain & Wellness Institute, Los Angeles, US.

Background: Background: Patients with chronic pain often have limited access to comprehensive care that includes behavioral pain management strategies. Virtual reality (VR) is an immersive technology and emerging digital behavioral pain therapeutic with analgesic efficacy for acute pain. We found no scientific literature on skills-based VR behavioral programs for chronic pain populations. Read More

Reg Anesth Pain Med 2020 May 4. Epub 2020 May 4.

Anesthesia Pain, UC San Diego, La Jolla, California, USA.

The development of chronic pain is a complex mechanism that is still not fully understood. Multiple somatic and visceral afferent pain signals, when experienced over time, cause a strengthening of certain neural circuitry through peripheral and central sensitization, resulting in the physical and emotional perceptual chronic pain experience. The mind-altering qualities of psychedelics have been attributed, through serotonin 2A (5-HT) receptor agonism, to 'reset' areas of functional connectivity (FC) in the brain that play prominent roles in many central neuropathic states. Read More

Int J Environ Res Public Health 2020 May 1;17(9). Epub 2020 May 1.

Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.

Patients with fibromyalgia syndrome (FMS) have a nonspecific postural balance disorder and a greater prevalence of falls.

Objective: to clarify which aspects of maintaining balance are associated with the impact of the disorder and with balance confidence.

Methods: A total of 182 persons with FMS agreed to participate in this study. Read More

Psychol Res Behav Manag 2020 16;13:343-353. Epub 2020 Apr 16.

Department of Psychology, San Diego State University, San Diego, CA, USA.

Purpose: Fibromyalgia syndrome (FMS) is a chronic musculoskeletal pain disorder that is characterized by persistent and widespread pain. FMS has been associated with sleep disturbance, mood disorders and depression. Racial/ethnic minorities are less likely to receive a diagnosis of FMS than White individuals. Read More

Int J Environ Res Public Health 2020 Apr 30;17(9). Epub 2020 Apr 30.

Psychology Department, Rey Juan Carlos University, 28922 Alcorcón, Spain.

The current study´s objective was to determine the relationship between stress-recovery state and cardiovascular response to an acute stressor in a sample of female fibromyalgia patients in comparison with a control group of healthy participants. The laboratory procedure was completed by 36 participants with fibromyalgia and by 38 healthy women who were exposed to an arithmetic task with harassment while blood pressure and heart rate were measured during task exposure. Read More

J Rheumatol 2020 May;47(5):650-651

Tufts University School of Medicine; Adjunct Faculty, Departments of Medicine and Nursing, Oregon Health Sciences University, Portland, Oregon, USA.

Int J Environ Res Public Health 2020 Apr 26;17(9). Epub 2020 Apr 26.

Faculty of Nursing and Physiotherapy, University of Lleida, 25198 Lleida, Spain.

Poor sleep quality is a common concern and a troublesome symptom among patients suffering from fibromyalgia. The purpose of this review was to identify and describe the available patient reported outcome measures (PROMs) of sleep quality validated in adult people diagnosed with fibromyalgia. The COSMIN and PRISMA recommendations were followed. Read More

Behav Med 2020 May 1:1-13. Epub 2020 May 1.

Department of Medicine and Surgery, Psychology, Preventive Medicine and Public Health, Medical Microbiology and Immunology, King Juan Carlos University, Madrid, Spain.

There is evidence regarding the presence of alterations in both the stress response and the endogenous pain modulation systems of people with fibromyalgia (FM). However, research on pain modulation under induced stress on FM patients is scarce and contradictory. The present study analyzes stress-induced changes in pain and intolerance thresholds among FM patients, examining the possible existence of differences linked to PTSD comorbidity and gaining insights into the role of cardiovascular reactivity. Read More

Curr Treatm Opt Rheumatol 2020 Apr 30:1-4. Epub 2020 Apr 30.

1Schulich School of Medicine & Dentistry, London, ON Canada.

Purpose Of Review: The COVID-19 outbreak has resulted in uncertainty for patients with autoimmune rheumatic diseases for several reasons. They are concerned about their risk of developing COVID-19 as many are immune suppressed from their disease and/or treatment, whether they should stop their advanced therapies, if they will have a worse outcome if/when infected due to their underlying medication condition(s) and if they will have drug availability, especially with press (without much data) coverage suggesting hydroxychloroquine may be used in COVID-19 infection causing diversion of medication supply. This article discusses how the pandemic affects people with systemic autoimmune rheumatic diseases. Read More

JAMA Otolaryngol Head Neck Surg 2020 Apr 30. Epub 2020 Apr 30.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.

Importance: Fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), and chronic fatigue syndrome (CFS) are traditionally considered as distinct entities grouped under chronic pain syndrome (CPS) of an unknown origin. However, these 3 disorders may exist on a spectrum with a shared pathophysiology.

Objective: To investigate whether the clinical presentation of FMS, IBS, and CFS is similar in a population presenting with voice and laryngeal disorders. Read More

Cutis 2020 Mar;105(3):E32-E33

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

BMJ Open 2020 Apr 28;10(4):e034697. Epub 2020 Apr 28.

Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, The Netherlands

Objectives: To analyse the association between the type of work (productive vs reproductive work) and the levels of physical activity and sedentary behaviour in women with fibromyalgia.

Method: This cross-sectional study involved 258 women with fibromyalgia from southern Spain. Of them, 55% performed reproductive work (unpaid, associated with caregiving and domestic roles) exclusively, while 45% had productive job (remunerated, that results in goods or services). Read More

BMJ 2020 Apr 28;369:m1315. Epub 2020 Apr 28.

James Cook University Hospital, Middlesbrough, UK.

J Clin Med 2020 Apr 24;9(4). Epub 2020 Apr 24.

Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Post-marketing surveillance activities are essential to detect the risk/benefit profile of biologic disease-modifying antirheumatic drugs (bDMARDs) in inflammatory arthritis. The aim of this study was to evaluate adverse events (AEs) in patients treated with bDMARDs in rheumatology during a prospective pharmacovigilance study from 2016 to 2018. Descriptive statistical analyses were performed to evaluate bDMARDs-related variables of patients without AEs/failures vs patients with AEs and failures. Read More

Metabolites 2020 Apr 24;10(4). Epub 2020 Apr 24.

Department of Internal Medicine, Division of Rheumatology, Dell Medical School, The University of Texas, 1701 Trinity St, Austin, TX 78712, USA.

Central sensitization syndromes are a collection of frequently painful disorders that contribute to decreased quality of life and increased risk of opiate abuse. Although these disorders cause significant morbidity, they frequently lack reliable diagnostic tests. As such, technologies that can identify key moieties in central sensitization disorders may contribute to the identification of novel therapeutic targets and more precise treatment options. Read More

Neuroimage 2020 Apr 25;216:116877. Epub 2020 Apr 25.

National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, USA.

Differences in fMRI resting-state connectivity of the default mode network (DMN) seen in chronic pain patients are often interpreted as brain reorganization due to the chronic pain condition. Nevertheless, patients' pain at the time of fMRI might influence the DMN because pain, like cognitive stimuli, engages attentional mechanisms and cognitive engagement is known to alter DMN activity. Here, we aimed to dissociate the influence of chronic pain condition (trait) from the influence of current pain experience (state) on DMN connectivity in patients with fibromyalgia (FM). Read More

Adv Exp Med Biol 2020 ;1228:233-253

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

In this chapter, we describe the impact and etiology of chronic pain, the associated changes in the nervous system, and the mechanisms by which exercise may be able to affect and reverse these changes. Evidence for efficacy of exercise in different conditions associated with chronic pain is presented, with focus on chronic low back pain, fibromyalgia, osteoarthritis, rheumatoid arthritis, and migraines. While the efficacy of exercise and level of evidence supporting it vary in different diseases, exercise has direct and indirect benefits for most patients suffering from chronic pain. Read More