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Diagnostics (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, Taiwan.

A 45-year-old male presented with acute-onset left-sided weakness and slurred speech. Non-contrast-enhanced brain magnetic resonance imaging revealed cortical and internal border-zone infarcts compatible with stroke. A survey of ischemic stroke risk factors in young adults excluded coagulopathy, vasculitis, and cardiac disease. Read More

Dtsch Arztebl Int 2022 09 5(Forthcoming). Epub 2022 Sep 5.

Background: Dissections of the cervical brain-supplying arteries are a leading cause of ischemic stroke in young adults, with an annual incidence of 2.5-3 / 100 000 for carotid artery dissection and 1-1.5 / 100 000 for vertebral artery dissection. Read More

J Am Heart Assoc 2022 Jun 14;11(12):e023858. Epub 2022 Jun 14.

Division of Cardiology, Department of Medicine Emory University School of Medicine Atlanta GA.

Background Fibromuscular dysplasia (FMD) is a disease of unknown etiology that causes stenosis, aneurysmal dilatation, and dissection of vascular beds. Known to affect medium-sized arteries, FMD is not typically considered to affect the aorta. We tested the hypothesis that aortic size in FMD is abnormal compared with age- and sex-matched controls. Read More

Cureus 2022 May 10;14(5):e24893. Epub 2022 May 10.

Internal Medicine, Rutgers-New Jersey Medical School/ Trinitas Regional Medical Center, Elizabeth, USA.

Levine's sign is a universal sign of ischemic chest pain, defined as an individual holding a clenched fist over the chest that has a low sensitivity but is relatively specific for ischemia. Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic and a very unusual cause of acute myocardial infarction.In literature,it has been more common in young women, postpartum, or with fibromuscular dysplasia. Read More

Eur Heart J 2022 Jun 2. Epub 2022 Jun 2.

Department of Cardiovascular Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, No.324 Jingwu Road, Jinan, Shandong 250021, China.

Eur Heart J Case Rep 2022 Apr 25;6(4):ytac125. Epub 2022 Mar 25.

Cardiology Department, Sunshine Coast University Hospital, Birtinya, Qld 4575, Australia.

Background: Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome and is associated with fibromuscular dysplasia (FMD). The diagnosis of stress cardiomyopathy in patients with SCAD and FMD is uncommon, though an important consideration given the shared risk profile. Complications of severe left ventricular (LV) dysfunction associated with stress cardiomyopathy, such as LV thrombus, complicate the management of SCAD where anticoagulation is controversial in the context of SCAD-associated intramural haematoma. Read More

Cureus 2022 Apr 27;14(4):e24527. Epub 2022 Apr 27.

Neuropathology, Instituto Nacional de Neurología y Neurocirugia, Mexico City, MEX.

Hemangioblastoma is considered a benign neoplasm characterized by abnormal vasculature and stromal cells; several pathophysiological mechanisms have been proposed, such as genetic predisposition, hormonal factors, and arterial wall ischemia. Fibromuscular dysplasia is characterized by hyperplasia or thinning of the smooth muscle, elastic fibre destruction, fibrous tissue proliferation, and arterial wall disorganization. We present a cerebellar hemangioblastoma case not associated with Von Hippel Lindau syndrome. Read More

Am J Forensic Med Pathol 2022 May 30. Epub 2022 May 30.

From the Department of Pathology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):179-184. Epub 2022 Mar 17.

Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

In this report, we detail a rare presentation of central retinal vein occlusion (CRVO) in a patient with fibromuscular dysplasia (FMD). A 45-year-old woman with a 12-year history of FMD presented to the ophthalmology clinic with symptoms and exam findings consistent with CRVO. Dilated fundus examination revealed disc edema, diffuse flame, and dot-blot hemorrhages, and tortuous, engorged retinal veins. Read More

Am J Cardiol 2022 Jul 11;175:38-43. Epub 2022 May 11.

Department of Cardiology, Clermont-Ferrand University Hospital Center, Centre National de la Recherche Scientifique, Clermont Auvergne University, Clermont-Ferrand, France.

Spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD) are pathologies that appear to be closely related. This study compares the characteristics of the FMD population to the non-FMD population in a SCAD cohort. It thus assesses the involvement of the FMD phenotype in a SCAD population. Read More

Cureus 2022 Apr 9;14(4):e23983. Epub 2022 Apr 9.

Cardiology, Saint Francis Medical Center, Trenton, USA.

Spontaneous coronary artery dissection (SCAD) is an infrequent presentation of acute myocardial infarction in young women and denotes the non-atherosclerotic separation of the coronary artery wall. Precipitating causes include fibromuscular dysplasia, postpartum hormonal changes, multiparity, connective tissue diseases like Marfan syndrome, autoimmune conditions, and hormonal therapy. It is often underdiagnosed due to a low index of suspicion based on age and gender bias as well as knowledge about different angiographic variants in SCAD. Read More

Neurol India 2022 Mar-Apr;70(2):792-793

Department of Neurology, Aster Medcity, Kochi, Kerala, India.

Cureus 2022 Mar 29;14(3):e23633. Epub 2022 Mar 29.

Cardiology, Hospital Universitario Sant Joan de Reus, Reus, ESP.

Spontaneous coronary artery dissection (SCAD) is an underdiagnosed cause of myocardial infarction (MI), and its prevalence among women is increasing. Epidemiological information indicates that SCAD is responsible for one-third of MI cases in women of reproductive age. Little information is described on SCAD in elderly patients. Read More

Cureus 2022 Mar 21;14(3):e23350. Epub 2022 Mar 21.

Cardiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.

Fibromuscular dysplasia (FMD) is a potentially treatable cause of renovascular hypertension and it typically affects young females. FMD usually involves distal two-thirds of the renal artery and percutaneous transluminal renal angioplasty (PTRA) is the treatment of choice for FMD with resistant hypertension. PTRA is a safe procedure with minimal complications. Read More

Nat Commun 2022 Apr 20;13(1):2251. Epub 2022 Apr 20.

Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Cureus 2022 Mar 11;14(3):e23069. Epub 2022 Mar 11.

Cardiology, Maine Medical Center, Portland, USA.

Spontaneous coronary artery dissection (SCAD) is an uncommon but important cause of acute myocardial infarction, particularly in younger women and in patients with underlying fibromuscular dysplasia (FMD). There is increasing literature on patients with SCAD reporting significant emotional stress, particularly stress related to unemployment, in the week prior to their cardiac event, and emotional triggers appear to be associated with worse in-hospital and follow-up cardiac events. Additionally, the COVID-19 pandemic has resulted in significant societal stressors and increased unemployment, which have been associated with increased cardiovascular morbidity. Read More

Arterioscler Thromb Vasc Biol 2022 05 7;42(5):597-609. Epub 2022 Apr 7.

University of Bordeaux, INSERM, Biologie des Maladies Cardiovasculaires, U1034, Pessac, France (S.R., P.B., S.M., A.A., V.D., M.P., S.J., M.-L.B., P.D., T.C., C.D.).

Background: Genome-wide association studies have revealed robust associations of common genetic polymorphisms in an intron of the PHACTR-1 (phosphatase and actin regulator 1) gene (chr6p24), with cervical artery dissection, spontaneous coronary artery dissection, and fibromuscular dysplasia. The aim was to assess its role in the pathogenesis of cervical artery dissection or fibromuscular dysplasia.

Methods: Using various tissue-specific Cre-driver mouse lines, was deleted either in endothelial cells using 2 tissue-specific Cre-driver (PDGFB [platelet-derived growth factor B]-Cre mice and Tie2 [tyrosine kinase with immunoglobulin and EGF homology domains]-Cre) and smooth muscle cells (smooth muscle actin-Cre) with a third tissue-specific Cre-driver. Read More

Clin Exp Rheumatol 2022 05 30;40(4):858-859. Epub 2022 Mar 30.

Rheumatology Unit, Università di Modena e Reggio Emilia and Azienda USL-IRCCS di Reggio Emilia, Italy.

Hellenic J Cardiol 2022 May-Jun;65:42-48. Epub 2022 Mar 25.

Department of Cardiology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. Electronic address:

Renal artery stenosis (RAS) may cause secondary hypertension, progressive decline in renal function, and cardiac destabilization syndromes including "flash" pulmonary edema, recurrent congestive heart failure, and cerebro-cardiovascular disease. Atherosclerotic lesions, fibromuscular dysplasia, and vasculitides are the pathophysiological basis of the disease. Common therapeutic pathways for RAS include medical therapy and revascularization with or without stenting. Read More

Cardiol Young 2022 Mar 24:1-4. Epub 2022 Mar 24.

Emergency Institute for Cardiovascular Diseases and Transplantation, Tîrgu Mureş, Romania.

Coronary artery disease of non-atherosclerotic aetiology, while rare in incidence, can have a wide aetiology, such as fibromuscular dysplasia, which is a non-inflammatory arteriopathy of numerous histopathological types of fibromuscular tissue accumulation. This brief report describes the case of a 22-year-old male with a recently developed dilated cardiomyopathy and a history of aborted cardiac arrest at the age of 14 years. Coronary angiogram revealed severe three vessels disease, while optical coherence tomography established fibromuscular dysplasia as aetiology. Read More

Radiol Case Rep 2022 May 2;17(5):1370-1375. Epub 2022 Mar 2.

Department of Vascular surgery, Department of Radiology, Clinique St-Pierre, University affiliated hospital (Université catholique de Louvain), 1340 Ottignies/Louvain-la-Neuve, Belgium.

Dissection of the common hepatic artery is a rare cause of acute abdomen. In this case report, we discuss a 58-year-old woman who presented with severe epigastric and back pain, for which she had an abdominal computed tomography (CT) scan. On CT images, a dissection of the common hepatic artery, extending to its right and left dividing branches and a diffusely pathological aspect of the hepatic and digestive arterial network was noted. Read More

Am J Cardiol 2022 May 12;171:65-68. Epub 2022 Mar 12.

Minneapolis Heart Institute Foundation, Minneapolis, Minnesota.

Spontaneous coronary artery dissection (SCAD) is a relatively newly diagnosed area, and evidence-based medicine (EBM) standards are emerging and currently include an aspirin, β blocker, clopidogrel, angiotensin-converting enzyme inhibitor/angiotensin-receptor blocker for patients with hypertension, vascular abnormality imaging, and cardiac rehabilitation. Because SCAD is an uncommon condition, many providers are unfamiliar with EBM treatment standards which could affect the implementation of recommended treatment. This study documented the frequency of failure to meet EBM SCAD treatment standards and factors contributing to conformance failure. Read More

Ann Vasc Surg 2022 Jul 12;83:35-41. Epub 2022 Mar 12.

Loma Linda University Medical Center, Loma Linda, CA.

Background: Renal artery stenosis (RAS) is an uncommon cause of pediatric hypertension. Guidelines for workup and management have not been established. The most widely reported etiology of the pediatric renovascular disease has been fibromuscular dysplasia; however, other etiologies including middle aortic syndrome (MAS) and vasculitides have been described. Read More

J Vasc Surg 2022 Jul 8;76(1):149-157. Epub 2022 Mar 8.

Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN.

Objective: Aneurysms of the superior mesenteric artery (SMA) and its branches are rare and account for only 6% to 15% of all visceral artery aneurysms. In the present report, we have described our 30-year experience with the management of aneurysms of the SMA and its branches at a high-volume referral center.

Methods: A retrospective review of all patients with a diagnosis of an aneurysm of the SMA or one of its branches from 1988 to 2018 was performed. Read More

J Am Heart Assoc 2022 03 9;11(6):e023655. Epub 2022 Mar 9.

Division of Hypertension and Nephrology National Cerebral and Cardiovascular Center Osaka Japan.

Background We investigated the early postoperative effect of percutaneous transluminal renal angioplasty on ambulatory blood pressure (BP) and the circadian characteristics of natriuresis and autonomic nerve activity. Methods and Results A total of 64 patients with hypertension with hemodynamically significant renal artery stenosis (mean age, 60.0±21. Read More

BMJ Case Rep 2022 Mar 3;15(3). Epub 2022 Mar 3.

Neurological Surgery, University of Miami School of Medicine, Miami, Florida, USA.

Fibromuscular dysplasia (FMD) is an arteriopathy of medium-sized vessels causing pathological arterial wall fragility. However, only minimal data exist on evaluating the risk of transradial access (TRA) in these patients. We describe the case of a woman in her 70s who underwent left middle meningeal artery embolisation for an acute-on-chronic subdural haematoma via right TRA. Read More

SA J Radiol 2022 28;26(1):2291. Epub 2022 Jan 28.

Department of Radiodiagnosis, Dr. DY Patil Medical College, Hospital and Research Centre, Pune, India.

Carotid webs are important, often undiagnosed causes of cryptogenic and recurrent strokes. CT angiography and digital subtraction angiography adequately demonstrate webs as linear filling defects in the carotid bulb. However, findings are overlooked unless viewed in optimal planes and easily misdiagnosed as dissection flaps or atheromatous plaques, altering management and outcome. Read More

Am J Med Genet A 2022 03;188(3):720-721

J Vasc Surg Cases Innov Tech 2022 Mar 23;8(1):119-120. Epub 2021 Dec 23.

Department of Clinical Science and Education, Karolinska Institutet, and Department of Surgery, Södersjukhuset, Stockholm, Sweden.

Surg Neurol Int 2022 20;13:26. Epub 2022 Jan 20.

Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan.

Background: Fibromuscular dysplasia (FMD) can cause cerebral aneurysms and dissection, which can lead to stroke. Angiographic findings are important in the diagnosis. We report a case of FMD in which the cause of hemorrhage could not be determined by angiography. Read More