2,842 results match your criteria Fibromuscular Dysplasia


FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy.

Circ Res 2021 Jun 10;128(12):1958-1972. Epub 2021 Jun 10.

Division of Cardiovascular Medicine, Department of Internal Medicine (S.K.G.), University of Michigan Medical School, Ann Arbor.

Multifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. Traditionally known in the context of renovascular hypertension, recent advances in knowledge about FMD have demonstrated that FMD is a systemic arteriopathy presenting as arterial stenosis, aneurysm, and dissection in virtually any arterial bed. FMD is also characterized by major cardiovascular presentations including hypertension, stroke, and myocardial infarction. Read More

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Endovascular interventions in main renal artery pathologies: an overview and update.

Acta Radiol 2021 Jun 9:2841851211019806. Epub 2021 Jun 9.

Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Renal arteries are involved in a wide spectrum of pathologies including atherosclerosis, fibromuscular dysplasia, Takayasu arteritis, aneurysms, and aortic type B dissections extending into main renal arteries. They manifest as renovascular hypertension, renal ischemia, and cardiovascular dysfunction. The location of the renal arteries in relation to the abdominal aortic aneurysm is a critical determinant of interventional options and long-term prognosis. Read More

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Baseline Brain-to-Pelvis Imaging Predicts Subsequent Arterial Complications in Patients With Renal Artery Dissection.

Hypertension 2021 Jul 9;78(1):62-64. Epub 2021 Jun 9.

Division of Cardiology, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium (A.P., S.C., M.P.).

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Fibromuscular Dysplasia Involving the Coronary Arteries.

Methodist Debakey Cardiovasc J 2021 Apr 25;17(1):71-72. Epub 2021 Mar 25.

Einstein Medical Center, Philadelphia, Pennsylvania.

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Symptomatic internal carotid artery dissection and kinking in a patient with fibromuscular dysplasia.

J Vasc Bras 2021 May 31;20:e20200243. Epub 2021 May 31.

"Vita - Salute" University, Scientific Institute H. San Raffaele, Milan, Italy.

Isolated dissection of the internal carotid artery (ICA) is rare in young patients and is a cause for strong suspicion of fibromuscular dysplasia (FMD), especially when associated with artery elongation and tortuosity. The natural history of cerebrovascular FMD is unknown and management of symptomatic patients can be challenging. We report the case of a 44-year-old female patient with a history of transient ischemic attack in the absence of cardiovascular risk factors, associated with an isolated left ICA dissection and kinking. Read More

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Stroke Recurrence in First-Ever Symptomatic Carotid Web: A Cohort Study.

J Stroke 2021 May 31;23(2):253-262. Epub 2021 May 31.

Neurology Department, Martinique University Hospital, Martinique.

Background And Purpose: Carotid web (CaW) is an intimal variant of fibromuscular dysplasia responsible for ipsilateral cerebral ischemic events (CIE). Symptomatic CaW likely has a high risk of recurrent CIE, but no salient prospective data are available. We aimed to assess recurrence rate and its predictors after a first-ever CIE. Read More

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Physical activity and exercise in patients with spontaneous coronary artery dissection and fibromuscular dysplasia.

Eur Heart J 2021 Jun 7. Epub 2021 Jun 7.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, 200 First St SW, MN 55905, USA.

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Refractory vasospastic angina in a patient with fibromuscular dysplasia: A case report.

J Cardiol Cases 2021 Jun 26;23(6):261-263. Epub 2020 Dec 26.

Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy.

A 49-year-old woman affected by fibromuscular dysplasia (FMD) of the carotid artery with recurrent coronary vasospasm, refractory to medical therapy was admitted for anginal pain. Coronary involvement related to FMD is uncommon and its diagnosis "in vivo" still represents a challenge. Although a clear association between FMD and spontaneous coronary artery dissections is described, the presentation as severe coronary vasospasm is rare and it is associated with unfavorable outcome, especially when treated by means of percutaneous coronary intervention. Read More

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Risk Factors and Incidence of Acute Ischemic Stroke: A Comparative Study Between Young Adults and Older Adults.

Cureus 2021 Apr 24;13(4):e14670. Epub 2021 Apr 24.

Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.

Introduction Approximately 5-10% of strokes occur in adults of less than 45 years of age. The rising prevalence of stroke risk factors may increase stroke rates in young adults (YA). We aimed to compare risk factors and outcomes of acute ischemic stroke (AIS) among YA. Read More

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Renal revascularization by a pedicled intestinal segment wrapping the kidney: a new method for kidney revascularization.

Int Urol Nephrol 2021 May 29. Epub 2021 May 29.

Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Renal artery stenosis is caused by a heterogeneous group of diseases, including atherosclerosis and fibromuscular dysplasia, which can be treated medically, via endovascular techniques, or by open revascularization; however, satisfactory and effective results are not always obtained. We aimed to assess the possibility of renal revascularization by a pedicled intestinal segment wrapping the kidney.

Methods: Five dogs were operated on at three steps. Read More

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Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications.

Cardiovasc Res 2021 May 28. Epub 2021 May 28.

Department of Cardiovascular Sciences and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.

Aims: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndromes and in rare cases sudden cardiac death (SCD). Connective tissue abnormalities, coronary inflammation, increased coronary vasa vasorum density and coronary fibromuscular dysplasia have all been implicated in the pathophysiology of SCAD but have not previously been systematically assessed. We designed a study to investigate the coronary histological and dermal collagen ultrastructural findings in SCAD. Read More

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Bilateral renal artery stenosis due to fibromuscular dysplasia presenting as superimposed pre-eclampsia.

BMJ Case Rep 2021 May 26;14(5). Epub 2021 May 26.

Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Renal vascular hypertension is a diagnosis that needs to be entertained in the setting of refractory, otherwise unexplained hypertension in pregnancy. Conclusive diagnosis of the condition is made by the use of angiography, which confers only a low, safe dose of radiation to the fetus, especially after the first trimester. Percutaneous angioplasty is effective in treating this condition and is best performed postnatally to avoid fetal exposure to ionising radiation. Read More

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Multivessel Spontaneous Coronary Artery Dissection With Coronary Artery Fibromuscular Dysplasia.

CJC Open 2021 May 1;3(5):687-689. Epub 2021 Jan 1.

Regional Cardiac Catheterization Lab, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

A 53-year-old woman underwent a cardiac catheterization for evaluation of acute coronary syndrome. The coronary angiogram revealed evidence of spontaneous coronary artery dissection in multiple coronary arteries including the left anterior descending artery, posterior descending artery, and posterior left ventricular artery. Further diagnostic imaging revealed associated bilateral vertebral artery and renal artery fibromuscular dysplasia (FMD). Read More

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Baseline Characteristics of Patients with Symptomatic Carotid Webs: A Matched Case Control Study.

J Stroke Cerebrovasc Dis 2021 May 21;30(8):105823. Epub 2021 May 21.

Department of Neurology, Emory University Hospital / Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, USA. Electronic address:

Background And Purpose: The baseline characteristics of patients with symptomatic carotid web (CaW) are unclear. We investigate demographic and cerebrovascular risk factors in patients with this overlooked stroke etiology.

Methods: We identified consecutive patients diagnosed with symptomatic CaW at a comprehensive stroke center from July 2014-December 2018. Read More

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Fibromuscular dysplasia with recurrence after "long-term" following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients.

BMC Nephrol 2021 May 20;22(1):187. Epub 2021 May 20.

Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Fibromuscular dysplasia (FMD) often causes renal artery stenosis with renovascular hypertension. Recent clinical outcomes encourage percutaneous transluminal renal angioplasty (PTRA) to treat FMD; however, the necessary follow-up period remains unclear. Moreover, previous studies have not revealed the difference in the period until recurrence between two major types of FMD-multifocal and focal. Read More

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Bilateral carotid webs.

Neuroradiol J 2021 May 18:19714009211017783. Epub 2021 May 18.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Carotid web is thought to be a focal intimal variant of fibromuscular dysplasia, which comprises a high risk of stroke because of blood stasis and subsequent coagulative reactions that occur distal to the web. These lesions generally involve the posterolateral wall of the carotid and their developmental pathogenesis is controversial. This case report describes a 51-year-old woman who presented to the hospital with sudden onset aphasia, right hemi-sensory loss, and right visual field cut. Read More

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Kidney donors with Fibromuscular Dysplasia, is it time to open the doors?

Nephrol Dial Transplant 2021 May 17. Epub 2021 May 17.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, 10 Avenue Hippocrate, 1200, Brussels, Belgium.

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Spontaneous coronary artery dissection.

Rev Clin Esp (Barc) 2021 May 31;221(5):297-305. Epub 2021 Mar 31.

Servicio de Cardiología, Complejo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), La Coruña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.

Spontaneous coronary artery dissection is an underdiagnosed entity. It has been recognized as an important cause of acute coronary syndrome and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. This document provides an exhaustive review of the pathophysiology and etiology of this disease. Read More

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Male Sex Is Associated With Cervical Artery Dissection in Patients With Fibromuscular Dysplasia.

J Am Heart Assoc 2021 Jun 17;10(11):e018311. Epub 2021 May 17.

Department of Neurology Inserm U1237 Normandie UniversitéUniversité Caen NormandieCHU Caen Normandie Caen France.

Background Cervical artery dissection (CeAD) is a frequent manifestation of fibromuscular dysplasia (FMD). However, risk factors for CeAD are unknown. We investigated factors associated with CeAD in the ARCADIA (Assessment of Renal and Cervical Artery Dysplasia) registry. Read More

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Prevalence of Cervical Artery Abnormalities on CTA in Patients with Spontaneous Coronary Artery Dissection: Fibromuscular Dysplasia, Dissection, Aneurysm, and Tortuosity.

AJNR Am J Neuroradiol 2021 May 13. Epub 2021 May 13.

Department of Cardiovascular Medicine (S.N.H., M.S.T.), Mayo Clinic, Rochester, Minnesota.

Background And Purpose: Little is known about associations between spontaneous coronary artery dissection and cervical artery abnormalities. This study sought to assess the prevalence of cervical artery abnormalities among patients with spontaneous coronary artery dissection.

Materials And Methods: A retrospective analysis was completed of patients who underwent CTA neck imaging as part of arterial assessment following the diagnosis of spontaneous coronary artery dissection. Read More

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High renin hypertension in focal renal fibromuscular dysplasia: turn off of renin system angiotensin overactivation by renal angioplasty cured high blood pressure and quickly reversed myocardial hypertrophy.

Acta Biomed 2021 04 30;92(S1):e2021162. Epub 2021 Apr 30.

University of Parma.

Background Fibromuscolar dysplasia (FMD) is an idiopathic, non-atherosclerotic and non-inflammatory stenotic lesion of renal arteries causing renovascular hypertension up-regulating renin-angiotensin-aldosterone system. Case report: A 18-year-old man was referred to our Hypertension Center (Clinica e Terapia Medica) for the recent onset of hypertension, poorly controlled on calcium channel blockers, already associated to electrocardiographic and echocardiography signs of left ventricular hypertrophy and significant albuminuria (728 mg/24 h). An increased plasma renin activity (PRA), aldosterone level and a mild hypokalemia raised the suspicion of renovascular hypertension. Read More

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Renal Arteries Revisited: Anatomy, Pathologic Entities, and Implications for Endovascular Management.

Radiographics 2021 May-Jun;41(3):909-928

From the Departments of Radiology (R.D.W., K.S.M., M.G.S., W.R.T., A.C.G., A.M.W.) and Vascular Surgery (I.M.W.), University Hospital of Wales, Heath Park, Cardiff CF14 4XW, Wales; and Department of Radiology, Ninewells Hospital and Medical School, Dundee, Scotland (I.A.Z.).

The renal arteries (RAs) are important vessels that usually arise from the abdominal aorta and supply the kidneys; thus, these arteries play a vital role in physiologic functions such as hemofiltration and blood pressure regulation. An understanding of the basis for embryologic development and the frequently variable anatomy of the RAs is necessary to fully appreciate the range of diseases and the implications for procedural planning. Hemorrhage from an RA is relatively common and is typically traumatic or spontaneous, with the latter form often seen in association with underlying tumors or arteriopathy. Read More

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Progress in aorta and peripheral cardiovascular disease research.

Cardiovasc Res 2021 Apr 22. Epub 2021 Apr 22.

Department of Cardiology, Dupuytren-2 University Hospital, and Inserm 1094 & IRD, Limoges University, Limoges, France.

Although COVID-19 seems to be the leading topic in researcha number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. Read More

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Renovascular hypertension in pediatric patients: update on diagnosis and management.

Pediatr Nephrol 2021 Apr 13. Epub 2021 Apr 13.

Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Renovascular hypertension (RVH) is defined as an elevated blood pressure caused by kidney hypoperfusion, generally as a result of anatomic stenosis of the renal artery with consequent activation of the Renin Angiotensin-Aldosterone System. The main causes include genetic and inflammatory disorders, extrinsic compression, and idiopathic alterations. RVH is often asymptomatic and should be suspected in any child with refractory hypertension, especially if other suggestive findings are present, including those with severe hypertension, abdominal bruit, and abrupt fall of glomerular filtration rate after administration of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. Read More

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Clinical characteristics and long-term outcomes of endovascular treatment of renal artery fibromuscular dysplasia with branch lesions.

Pediatr Nephrol 2021 Apr 10. Epub 2021 Apr 10.

Department of Vascular and Endovascular Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, 7#Weiwu Road, Zhengzhou, Henan, 450003, China.

Background: Renal artery fibromuscular dysplasia (FMD) can cause arterial stenosis, dissection, and aneurysm of renal arteries. This study aimed to analyze the clinical characteristics and evaluate the long-term outcomes of renal branch artery FMD in children and adults.

Methods: Sixty-one patients with renal artery FMD underwent endovascular treatment, including 23 children and 38 adults. Read More

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Ex-Vivo Repair of Complex Hilar Renal Artery Aneurysms and Auto-Transplantation of Solitary Kidney.

Ann Vasc Surg 2021 Apr 5. Epub 2021 Apr 5.

Division of Transplant Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.

Renal artery aneurysms (RAA) are rare and challenging to repair. We present a case of a 48-year-old female with solitary right kidney who had complex aneurysms near the renal hilum. CT angiogram showed fibromuscular dysplasia (FMD) features of the renal artery and 2 saccular aneurysms measuring 2. Read More

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Fibromuscular dysplasia with unilateral renal agenesis.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Internal Medicine, University of Missouri Kansas City, Kansas City, Missouri, USA.

Fibromuscular dysplasia (FMD) is predominantly diagnosed in women and is a congenital malformation damaging the arterial cell walls of numerous arteries, most prominently impacting the renal arteries. Although previously believed to be a disease of young women, older patients have been shown to make up a large percentage of this patient population as well. FMD is underdiagnosed, and the misdiagnosis of this disease has life-threatening consequences. Read More

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Spontaneous Coronary Artery Dissection in Patients With Fibromuscular Dysplasia.

Cureus 2021 Mar 4;13(3):e13696. Epub 2021 Mar 4.

Medicine, Ghurki Hospital, Lahore, PAK.

Clinicians must be mindful of angiographic appearances in patients with spontaneous coronary artery dissection (SCAD) in the setting of fibromuscular dysplasia (FMD) for the timely management of these high-risk patients. The objective is to highlight the clinical diagnostic and treatment modalities in rare case presentations of patients presenting with concurrent SCAD and FMD presentation. A qualitative review of scholarly materials. Read More

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An Outline of Renal Artery Stenosis Pathophysiology-A Narrative Review.

Authors:
Lukasz Dobrek

Life (Basel) 2021 Mar 7;11(3). Epub 2021 Mar 7.

Department of Clinical Pharmacology, Wroclaw Medical University, Wroclaw, Poland.

Renal artery stenosis (RAS) is conditioned mainly by two disturbances: fibromuscular dysplasia or atherosclerosis of the renal artery. RAS is an example of renovascular disease, with complex pathophysiology and consequences. There are multiple pathophysiological mechanisms triggered in response to significant renal artery stenosis, including disturbances within endothelin, kinin-kallikrein and sympathetic nervous systems, with angiotensin II and the renin-angiotensin-aldosterone system (RAAS) playing a central and key role in the pathogenesis of RAS. Read More

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