Arterioscler Thromb Vasc Biol 2022 05 7;42(5):597-609. Epub 2022 Apr 7.
University of Bordeaux, INSERM, Biologie des Maladies Cardiovasculaires, U1034, Pessac, France (S.R., P.B., S.M., A.A., V.D., M.P., S.J., M.-L.B., P.D., T.C., C.D.).
Background: Genome-wide association studies have revealed robust associations of common genetic polymorphisms in an intron of the PHACTR-1 (phosphatase and actin regulator 1) gene (chr6p24), with cervical artery dissection, spontaneous coronary artery dissection, and fibromuscular dysplasia. The aim was to assess its role in the pathogenesis of cervical artery dissection or fibromuscular dysplasia.
Methods: Using various tissue-specific Cre-driver mouse lines, was deleted either in endothelial cells using 2 tissue-specific Cre-driver (PDGFB [platelet-derived growth factor B]-Cre mice and Tie2 [tyrosine kinase with immunoglobulin and EGF homology domains]-Cre) and smooth muscle cells (smooth muscle actin-Cre) with a third tissue-specific Cre-driver. Read More