101 results match your criteria Fibrolamellar Hepatocellular Carcinoma Imaging


Pediatric fibrolamellar hepatocellular carcinoma: case report and review of the literature.

Acta Chir Belg 2021 Jun 5;121(3):204-210. Epub 2019 Sep 5.

Department of Hepatobiliairy Surgery, Antwerp University Hospital, Antwerp, Belgium.

Background: A 13-year-old boy presented with acute abdominal pain in the right upper quadrant without previous trauma. Abdominal ultrasound (US) revealed a mass in the right liver lobe with free intraperitoneal fluid, suggestive for hemoperitoneum. Magnetic resonance imaging confirmed a subcapsular lesion (5. Read More

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Magnetic resonance imaging of pediatric liver tumors.

Pediatr Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Liver tumors in children can be benign or malignant. Although several clinical factors are important in the evaluation of these lesions, MRI is particularly important for lesion characterization and tumor staging. In children, use of a hepatobiliary contrast agent is recommended to evaluate a known or suspected liver lesion. Read More

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Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma.

Children (Basel) 2021 Mar 16;8(3). Epub 2021 Mar 16.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Pulmonary ossification (PO) is a rare finding, characterized by mature bone formation in the lung parenchyma. We report a 20-year-old female patient diagnosed with fibrolamellar hepatocellular carcinoma (FL-HCC) and bilateral diffuse nodular PO. The patient presented with a unifocal left liver mass and multiple bilateral pulmonary lesions, which were treated as metastatic disease. Read More

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Extrahepatic transarterial radioembolization to treat fibrolamellar hepatocellular carcinoma: A case report.

Radiol Case Rep 2020 Dec 12;15(12):2613-2616. Epub 2020 Oct 12.

Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare primary liver tumor that typically presents at an advanced stage in early adolescents and adults with no underlying liver disease. Surgical resection is the first-line treatment, and patients who are not surgical candidates face limited treatment options with poor long-term outcomes. Herein we report the first documented, technically successful treatment of FL-HCC with extrahepatic spread using transarterial radioembolization (TARE) in a 16-year-old male patient with surgically unresectable disease. Read More

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December 2020

Imaging findings of fibrolamellar hepatocellular carcinomas on ultrasonography: A comparison with conventional hepatocellular carcinomas.

Clin Hemorheol Microcirc 2021 ;77(1):49-60

School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore.

Background: Fibrolamellar hepatocellular carcinoma (FLHCC) is an unusual variant of hepatocellular carcinoma (HCC). Revealing the imaging features is important to the diagnosis of FLHCC.

Objective: The aim of this study was to investigate the imaging characteristics of FLHCCs. Read More

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Clinicopathological Features of Two Extremely Rare Hepatocellular Carcinoma Variants: a Brief Review of Fibrolamellar and Scirrhous Hepatocellular Carcinoma.

J Gastrointest Cancer 2020 Dec;51(4):1187-1192

Liver Institute, Pathology Department, Inonu University, School of Medicine, Malatya, Turkey.

Purpose: We aimed to distinguish between fibrolamellar hepatocellular carcinoma and scirrhous hepatocellular carcinoma histopathologically.

Methods And Results: In this review, fibrolamellar hepatocellular carcinoma and scirrhous hepatocellular carcinoma two specific and rare variants of hepatocellular carcinoma, which are difficult to diagnose histopathologically are discussed.

Conclusion: The clinical, radiological, gross, histopathological, immunohistochemical, and molecular features of these two tumors, which are defined by the World Health Organization (WHO), are mentioned. Read More

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December 2020

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.

Cell 2020 09 25;182(6):1531-1544.e15. Epub 2020 Aug 25.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

The fidelity of intracellular signaling hinges on the organization of dynamic activity architectures. Spatial compartmentation was first proposed over 30 years ago to explain how diverse G protein-coupled receptors achieve specificity despite converging on a ubiquitous messenger, cyclic adenosine monophosphate (cAMP). However, the mechanisms responsible for spatially constraining this diffusible messenger remain elusive. Read More

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September 2020

Clinical features and surgical outcomes of fibrolamellar hepatocellular carcinoma: retrospective analysis of a single-center experience.

World J Surg Oncol 2020 May 12;18(1):93. Epub 2020 May 12.

Department of General, Visceral, and Transplantation Surgery, Ruprecht Karls University Hospital, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Background: Clinicopathological features and surgical outcomes of patients with fibrolamellar hepatocellular carcinoma (FL-HCC) are underreported. The aim of this study is to describe clinical characteristics and surgical outcomes for patients with this rare tumor to raise awareness among clinicians and surgeons.

Methods: Retrospective review of records of a tertiary referral center and specialized liver unit was performed. Read More

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DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma.

Dis Model Mech 2020 04 30;13(4). Epub 2020 Apr 30.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA

Fibrolamellar carcinoma (FLC) is a rare liver cancer that affects adolescents and young adults. Genomic analysis of FLC has revealed a 400 kb deletion in chromosome 19 that leads to the chimeric transcript (DnaJ-PKAc), comprised of the first exon of heat shock protein 40 () and exons 2-10 of the catalytic subunit of protein kinase A ). Here, we report a new zebrafish model of FLC induced by ectopic expression of zebrafish Dnaja-Pkaca (zfDnaJa-Pkaca) in hepatocytes that is amenable to live imaging of early innate immune inflammation. Read More

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Imaging Features of Fibrolamellar Hepatocellular Carcinoma with Contrast-Enhanced Ultrasound.

Ultraschall Med 2021 Jun 26;42(3):306-313. Epub 2020 Feb 26.

Department Allgemeine Innere Medizin, Kliniken Hirslanden Beau Site, Salem und Permanence, Switzerland.

Purpose:  Fibrolamellar hepatocellular carcinoma (f-HCC) is a rare primary liver tumor. Imaging plays an important role in diagnosis. The aim of this retrospective study was to analyze contrast-enhanced ultrasound (CEUS) features of histologically proven f-HCC in comparison to benign focal nodular hyperplasia (FNH). Read More

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State-of-the-art MR Imaging of Uncommon Hepatocellular Tumours: Fibrolamellar Hepatocellular Carcinoma and Combined Hepatocellularcholangiocarcinoma.

Curr Med Imaging Rev 2019 ;15(3):269-280

Department of Radiology, Maria Sklodowska-Curie Memorial Cancer Centre, Institute of Oncology, Warsaw, Poland.

Background: Fibrolamellar Carcinoma (FLC) and Combined Hepatocellular- Cholangiocarcinoma (CHC) are rare primary liver tumours, which are related to different clinical settings. In both tumours, correlation with clinical data and laboratory tests are extremely important.

Discussion: Typically, FLC is diagnosed in young patients without any chronic disease and with normal biochemical tests, whereas CHC arises in cirrhotic patients with elevated tumour markers: AFP and/or CA 19-9. Read More

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DNAJB1-PRKACA-positive metastatic fibrolamellar carcinoma with unknown primary in a pediatric patient.

Pediatr Blood Cancer 2020 02 17;67(2):e28060. Epub 2019 Nov 17.

Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Fibrolamellar carcinoma (FLC) is a rare variant of hepatocellular carcinoma, occurring in children and young adults without underlying liver disease. The diagnosis is based on morphological characteristics of the tumor, supplemented by immunohistochemistry and/or genetic testing. Recently, the presence of a characteristic DNAJB1-PRKACA fusion gene has been associated with FLC. Read More

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February 2020

Clavicle tumor as an initial manifestation of fibrolamellar hepatocellular carcinoma.

Rev Gastroenterol Mex (Engl Ed) 2020 Jan - Mar;85(1):104-106. Epub 2019 Oct 31.

Aparato Digestivo, Hospital García Orcoyen, Estella, España.

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December 2020

Spontaneous Rupture of Fibrolamellar Variant Hepatocellular Carcinoma.

Gastroenterology Res 2019 Jun 7;12(3):166-170. Epub 2019 Jun 7.

Staten Island University Hospital, Staten Island, NY, USA.

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a unique variant of hepatocellular carcinoma. The majority of cases present with nonspecific symptoms like vague abdominal pain, weight loss and fatigue. Ruptured FL-HCC occurs rarely and mortality in the acute phase is very high. Read More

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Percutaneous Creation of Intrahepatic Biliary Tract for Treatment of Posthepatectomy Excluded Segmental Bile Duct Leak.

J Vasc Interv Radiol 2018 12;29(12):1770-1772

Department of Radiology, Lahey Hospital and Medical Center, 41 Mall Rd., Burlington, MA 01805.

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December 2018

Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy.

Intern Med 2018 Dec 10;57(24):3537-3543. Epub 2018 Aug 10.

Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.

A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) with multiple lung metastases, and chemotherapy with FOLFOX was administered. Contrast enhanced CT after 3 cycles of FOLFOX showed no disease progression. We therefore performed surgical resection and radiofrequency ablation of the liver lesions and lung metastases, after obtaining the patient's informed consent. Read More

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December 2018

Fibrolamellar hepatocellular carcinoma: multiphasic CT features of the primary tumor on pre-therapy CT and pattern of distant metastases.

Abdom Radiol (NY) 2018 12;43(12):3340-3348

Division of Diagnostic Imaging, Body Imaging Section, Unit 1473, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030-4009, USA.

Objective: The aim of our study is to describe the multiphasic CT features of fibrolamellar hepatocellular carcinomas (FLHCCs) and pattern of distant metastases.

Materials And Methods: 33 patients (mean age 28 years: 17M/16F) with pathologically confirmed FLHCC and pre-treatment multiphasic CT were included in the study. Two abdominal radiologists evaluated the multiphasic CT imaging features of these 33 FLHCC patients in consensus. Read More

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December 2018

Large Hepatic Mass in an Adolescent Male.

Gastroenterology 2018 10 5;155(4):e9-e10. Epub 2018 Jun 5.

Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.

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October 2018

Jaundice in a pregnant woman.

Acta Gastroenterol Belg 2017 Jul-Sep;80(3):422-424

Service de Gastro-entérologie, CHU Tivoli (ULB), La Louvière, Belgium.

A 34-year-old woman in the 22nd week of gestation presented with generalized pruritis and weight loss since the first trimester of pregnancy. Physical examination revealed cutaneous scratch lesions, jaundice, and hepatomegaly. Blood tests revealed cholestasis with elevated direct bilirubinemia. Read More

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Curative lung metastectomy and complete pathological response after neo-adjuvant GEMOX chemotherapy for relapse fibrolamellar hepatocellular carcinoma.

Med J Malaysia 2018 02;73(1):46-48

Sarawak General Hospital, Department of Radiotherapy and Oncology, Sarawak, Malaysia.

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of hepatocellular carcinoma. It is commonly reported in the younger population with no underlying chronic liver disease and free of viral Hepatitis B and C. Local recurrence and distant metastasis are common despite better prognosis compared to conventional hepatocellular carcinoma. Read More

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February 2018

Hardened Liver Due to Fibrolamellar Hepatocellular Carcinoma.

Clin Gastroenterol Hepatol 2019 01 2;17(1):A27. Epub 2018 Mar 2.

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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January 2019

Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI.

Cancer Imaging 2018 Mar 1;18(1). Epub 2018 Mar 1.

Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, INF 110, 69120, Heidelberg, Germany.

Background: Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP.

Methods: In this retrospective study on histology-proven FLC, contrast material uptake in HBP was quantitatively assessed by calculating the corrected FLC enhancement index (CEI) using mean signal intensities of FLC and lumbar muscle on pre-contrast imaging and HBP, respectively. Read More

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Intracranial metastasis in fibrolamellar hepatocellular carcinoma.

Pediatr Blood Cancer 2018 04 29;65(4). Epub 2017 Dec 29.

Laboratory of Cellular Biophysics, The Rockefeller University, New York City, New York.

Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Read More

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MRI features of primary rare malignancies of the liver: A report from four university centres.

Eur Radiol 2018 Apr 27;28(4):1529-1539. Epub 2017 Oct 27.

Department of Radiology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC, 27514, USA.

Purpose: To determine if rare primary malignancies of the liver may have consistent features on magnetic resonance imaging (MRI).

Materials And Methods: This IRB-compliant retrospective study reviewed the records from the pathology departments of four university centres over an 11-year period from 2005-2016 to identify rare primary malignant tumours, which were cross-referenced with MRI records. MRI studies of these patients were reviewed to determine if these tumours exhibited consistent and distinctive features. Read More

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An unusual case of jaundice: Biliary tumor thrombus in fibrolamellar hepatocellular carcinoma.

Int J Surg Case Rep 2017 12;36:50-54. Epub 2017 May 12.

Department of Surgery, Western Michigan University Homer Stryker School of Medicine/West Michigan Cancer Center, Kalamazoo, MI, United States. Electronic address:

Background: Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare and unique variant of hepatocellular carcinoma (HCC) whose presentation remains inadequately described. We present a resectable case of FL-HCC which involved tumor thrombus of the common bile duct.

Presentation: A 27 year-old male presenting with jaundice, abdominal pain, vomiting, hepatic dysfunction and hyperbilirubinemia was found to have a large liver mass and lymphadenopathy on preoperative imaging. Read More

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Fibrolamellar hepatocellular carcinoma with ovarian metastasis - an unusual presentation.

Rom J Morphol Embryol 2017 ;58(1):187-192

Center of General Surgery and Liver Transplantation, "Fundeni" Clinical Institute, Bucharest, Romania;

Aim: Fibrolamellar carcinoma (FLC) has been considered a distinct clinical entity vs. hepatocellular carcinoma, with respect to its epidemiology, etiology, and prognosis.

Case Presentation: We describe the unusual case of a 23-year-old female patient with FLC and ovarian (Krukenberg) and peritoneal metastases, clinically mimicking an ovarian carcinoma. Read More

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Fibrolamellar hepatocellular carcinoma: a rare entity diagnosed by abdominal ultrasound.

Rev Esp Enferm Dig 2016 Aug;108(8):494-5

Medicina de Aparato Digestivo, Hospital Clínico Universitario Virgen de la rrixac, España.

We present the case of a young man with a hepatic mass in which ultrasound gives great and immediate support for diferential diagnosis. Read More

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Fibrolamellar hepatocellular carcinoma in ascitic fluid: A case report with cytohistological correlation.

Diagn Cytopathol 2016 Sep 24;44(9):757-60. Epub 2016 May 24.

Cytology Division, Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.

The fibrolamellar variant of hepatocellular carcinoma (FL-HCC) is distinguished from other hepatocellular carcinoma's (HCC) by its unique clinical and pathological features. Cytological features of this tumor on fine needle aspiration have been described earlier. We report a rare case of a 17-year-old African American male with metastatic FL-HCC, diagnosed by body fluid cytology. Read More

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September 2016

Contemporary management of fibrolamellar hepatocellular carcinoma: diagnosis, treatment, outcome, prognostic factors, and recent developments.

World J Surg Oncol 2016 May 23;14(1):151. Epub 2016 May 23.

Department of Surgery II, Faculty of Medicine, Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, OKL, University of Leipzig, Liebig Strasse 20, 04103, Leipzig, Germany.

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a malignant liver tumor which is thought to be a variant of conventional hepatocellular carcinoma (HCC). It accounts for a small proportion of HCC cases and occurs in a distinctly different group of patients which are young and usually not in the setting of chronic liver disease. The diagnosis of FL-HCC requires the integration of clinical information, imaging studies, and histology. Read More

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EDUCATION AND IMAGING. Hepatobiliary and Pancreatic: Post-transplant recurrence of fibrolamellar hepatocellular carcinoma in lung and pancreas.

Authors:
Ba Duong Nguyen

J Gastroenterol Hepatol 2016 Feb;31(2):286

Mayo Clinic Arizona, Department of Radiology, Scottsdale, Arizona, USA.

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February 2016