5,659 results match your criteria Fibrogenesis & Tissue Repair [Journal]


Hypoxia inducible factor-1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Endocrinology and Metabolism, Qingdao Haici Hospital, Qingdao, Shandong, China.

Obesity is a major contributor to the development of steatohepatitis and fibrosis from nonalcoholic fatty liver disease (NAFLD). Hypoxia aggravates progression of NAFLD. In mice on high-fat diet (HFD), hepatic steatosis leads to liver tissue hypoxia, evidenced by accumulation of hypoxia inducible factor-1-alpha (HIF-1α), which is a central regulator of the global response to hypoxia. Read More

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http://dx.doi.org/10.1002/jcb.28734DOI Listing

Sirtuin 6 inhibits MWCNTs-induced epithelial-mesenchymal transition in human bronchial epithelial cells via inactivating TGF-β1/Smad2 signaling pathway.

Toxicol Appl Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China. Electronic address:

Multi-walled carbon nanotubes (MWCNTs) have been developed with numerous beneficial applications. However, rodent models demonstrate that exposure to MWCNTs via respiratory pathways results in pulmonary fibrosis. Therefore, they could elicit a potential risk of pulmonary fibrosis in humans due to occupational or consumer exposure. Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.013DOI Listing

Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans.

Obesity (Silver Spring) 2019 Apr 19. Epub 2019 Apr 19.

Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri, USA.

Objective: Connective tissue growth factor (CTGF) is an important regulator of fibrogenesis in many organs. This study evaluated the interrelationship among adipose tissue CTGF expression, fat mass, and insulin resistance in humans.

Methods: This study examined (1) CTGF gene expression in human subcutaneous preadipocytes before and after inducing adipogenesis; (2) relationships among abdominal subcutaneous adipose tissue CTGF gene expression, body fat mass, and indices of insulin sensitivity, including the hepatic insulin sensitivity index and the hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotope glucose tracer infusion, in 72 people who had marked differences in adiposity and insulin sensitivity; (3) localization of CTGF protein in subcutaneous adipose tissue; and (4) effect of progressive (5%, 11%, and 16%) weight loss on adipose tissue CTGF gene expression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22463
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http://dx.doi.org/10.1002/oby.22463DOI Listing
April 2019
1 Read

A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.

Arch Toxicol 2019 Apr 19. Epub 2019 Apr 19.

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.

Previous epidemiological studies have suggested a link between high-cholesterol intake and liver disease progression, including hepatocellular carcinoma (HCC). However, the precise mechanism of hepatotoxicity and hepatocarcinogenesis caused by excessive cholesterol consumption remains unclear. We aimed to investigate the impact of dietary cholesterol using hepatitis C virus core gene transgenic (HCVcpTg) mice, which spontaneously developed HCC with age. Read More

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http://dx.doi.org/10.1007/s00204-019-02440-7DOI Listing
April 2019
5.980 Impact Factor

Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis.

Am J Pathol 2019 Apr 12. Epub 2019 Apr 12.

Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina; Department of Medicine, Durham Veterans Affairs Medical Centers, Durham, North Carolina. Electronic address:

Most forms of chronic kidney disease culminate in renal fibrosis that heralds organ failure. In contrast to the protective effects of globally blocking type 1 angiotensin (AT) receptors throughout the body, activating AT receptors directly on immune cells may serve protective functions. However, the effects of stimulating the T-cell AT receptor on the progression of renal fibrosis remain unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183107
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http://dx.doi.org/10.1016/j.ajpath.2019.02.004DOI Listing
April 2019
1 Read
4.591 Impact Factor

Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation.

Exp Mol Med 2019 Apr 15;51(4):42. Epub 2019 Apr 15.

Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, 800, Xiangyin Road, 200433, Shanghai, P. R. China.

As a common serious complication of thoracic radiotherapy, radiation-induced pulmonary fibrosis (RIPF) severely limits radiation therapy approaches. Epithelial-mesenchymal transition (EMT) is a direct contributor to the fibroblast pool during fibrogenesis, and prevention of EMT is considered an effective strategy to inhibit tissue fibrosis. Our previous study revealed that TANK-binding kinase 1 (TBK1) regulates EMT in lung cancer cells. Read More

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http://dx.doi.org/10.1038/s12276-019-0240-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465273PMC

SOHO State of the Art Updates and Next Questions: Myelofibrosis.

Clin Lymphoma Myeloma Leuk 2019 Mar 22. Epub 2019 Mar 22.

University of Michigan Rogel Cancer Center, Ann Arbor, MI.

The discovery of a mutation in the Janus Kinase 2 gene in 2005 spurred significant progress in the field of myeloproliferative neoplasms. A comprehensive description of genomic factors at play in the malignant clone in myeloproliferative neoplasms, particularly myelofibrosis (MF), have recently led to more precise, personalized prognostic tools. Despite this, understanding of the disease pathogenesis remains relatively limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21522650193017
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http://dx.doi.org/10.1016/j.clml.2019.03.011DOI Listing
March 2019
2 Reads

Silybin Modulates Collagen Turnover in an In Vitro Model of NASH.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Fondazione Italiana Fegato, ONLUS, AREA Science Park Basovizza SS 14 km 163.5, 34149 Trieste, Italy.

Silybin has been proposed as a treatment for nonalcoholic steatohepatitis (NASH). In this study, we assessed the effect of Silybin in a well-established in vitro coculture model of early-stage NASH. LX2 and Huh7 cells were exposed to free fatty acid (FFA) and Silybin as mono- or coculture (SCC). Read More

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http://dx.doi.org/10.3390/molecules24071280DOI Listing

LOXL2-A New Target in Antifibrogenic Therapy?

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Digestive Disease Department, Marqués de Valdecilla University Hospital, Cantabria University, 39008 Santander, Spain.

The concept of liver fibrosis and cirrhosis being static and therefore irreversible is outdated. Indeed, both human and animal studies have shown that fibrogenesis is a dynamic and potentially reversible process that can be modulated either by stopping its progression and/or by promoting its resolution. Therefore, the study of the molecular mechanisms involved in the pathogenesis of liver fibrosis is critical for the development of future antifibrotic therapies. Read More

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https://www.mdpi.com/1422-0067/20/7/1634
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http://dx.doi.org/10.3390/ijms20071634DOI Listing
April 2019
2 Reads

Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis.

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in western countries. Despite the high prevalence of NAFLD, the underlying biology of the disease progression is not clear, and there are no approved drugs to treat non-alcoholic steatohepatitis (NASH), the most advanced form of the disease. Thus, there is an urgent need for developing advanced in vitro human cellular systems to study disease mechanisms and drug responses. Read More

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https://www.mdpi.com/1422-0067/20/7/1629
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http://dx.doi.org/10.3390/ijms20071629DOI Listing
April 2019
6 Reads

The regulation of beef quality by resident progenitor cells.

J Anim Sci 2019 Apr 15. Epub 2019 Apr 15.

School of Animal Sciences, Louisiana State University Agricultural Center, Baton Rouge, LA.

The intramuscular adipose tissue deposition in the skeletal muscle of beef cattle is a highly desired trait essential for high-quality beef. In contrast, the excessive accumulation of crosslinked collagen in intramuscular connective tissue contributes to beef toughness. Recent studies revealed that adipose tissue and connective tissue share an embryonic origin in mice and may be derived from a common immediate bipotent precursor in mice and humans. Read More

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http://dx.doi.org/10.1093/jas/skz111DOI Listing
April 2019
1 Read

Fucoxanthin exerts anti-fibrogenic effects in hepatic stellate cells.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA; Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea. Electronic address:

The objective of this study was to evaluate whether fucoxanthin (FCX) have anti-fibrogenic properties in hepatic stellate cells (HSCs). FCX significantly decreased basal and transforming growth factor β1 (TGFβ1)-induced mRNA levels of fibrogenic genes with concomitant decreases in their protein levels in LX-2 cells. The phosphorylation of SMA- and MAD-related protein (SMAD3) was increased by TGFβ1, which was attenuated by FCX. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193068
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http://dx.doi.org/10.1016/j.bbrc.2019.04.052DOI Listing
April 2019
2 Reads

Pathogenesis of fibrostenosing Crohn's disease.

Transl Res 2019 Mar 26. Epub 2019 Mar 26.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the gastrointestinal tract. A severe complication of CD is fibrosis-associated strictures, which can cause bowel obstruction. Unfortunately, there is no specific antifibrotic therapy available. Read More

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http://dx.doi.org/10.1016/j.trsl.2019.03.005DOI Listing
March 2019
3 Reads

Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis.

Hum Exp Toxicol 2019 Apr 12:960327119842633. Epub 2019 Apr 12.

1 Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, Liaoning, People's Republic of China.

Paraquat (PQ) is a highly toxic herbicide to humans. Pulmonary fibrosis is one of the most typical features of PQ poisoning, which develops from several days to weeks after ingestion. However, the mechanism of fibrosis is still unclear. Read More

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http://dx.doi.org/10.1177/0960327119842633DOI Listing
April 2019
1 Read

Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway.

Lab Invest 2019 Apr 11. Epub 2019 Apr 11.

Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.

Micheliolide (MCL), derived from parthenolide (PTL), is known for its antioxidant and anti-inflammatory effects and has multiple roles in inflammatory diseases and tumours. To investigate its effect on renal disease, we intragastrically administrated DMAMCL, a dimethylamino Michael adduct of MCL for in vivo use, in two renal fibrosis models-the unilateral ureteral occlusion (UUO) model and an ischaemia-reperfusion injury (IRI) model and used MCL in combination with transforming growth factor beta 1 (TGF-β1) on mouse tubular epithelial cells (mTEC) in vitro. The expression of fibrotic markers (fibronectin and α-SMA) was remarkably reduced, while the expression of the epithelial marker E-cadherin was restored after DMAMCL treatment both in the UUO and IRI mice. Read More

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http://www.nature.com/articles/s41374-019-0245-6
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http://dx.doi.org/10.1038/s41374-019-0245-6DOI Listing
April 2019
2 Reads

Recent Insight into the Role of Fibrosis in Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma.

Int J Mol Sci 2019 Apr 9;20(7). Epub 2019 Apr 9.

HUMANITAS Gradenigo, University of Turin, 10132 Turin, Italy.

Hepatocellular carcinoma (HCC) is one of the most widespread tumors in the world and its prognosis is poor because of lack of effective treatments. Epidemiological studies show that non-alcoholic steatohepatitis (NASH) and advanced fibrosis represent a relevant risk factors to the HCC development. However little is known of pathophysiological mechanisms linking liver fibrogenesis to HCC in NASH. Read More

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http://dx.doi.org/10.3390/ijms20071745DOI Listing
April 2019
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A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

Hepatology 2019 Apr 4. Epub 2019 Apr 4.

Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Precision cut liver slices (PCLS) retain the structure and cellular composition of the native liver and represent an improved system to study liver fibrosis compared to two-dimensional mono or co-cultures. The aim of this study was to develop a bioreactor system to increase the healthy lifespan of PCLS and model fibrogenesis. PCLS were generated from normal rat or human liver, or fibrotic rat liver and cultured in our bioreactor. Read More

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http://dx.doi.org/10.1002/hep.30651DOI Listing
April 2019
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The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma.

Int J Mol Sci 2019 Apr 7;20(7). Epub 2019 Apr 7.

Department of Surgery, UC San Diego, La Jolla, CA 92093, USA.

Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury, hepatic inflammation, and fibrosis. Hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) are key players in liver fibrogenesis and hepatocarcinogenesis, respectively. Read More

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https://www.mdpi.com/1422-0067/20/7/1723
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http://dx.doi.org/10.3390/ijms20071723DOI Listing
April 2019
7 Reads

Pien-Tze-Huang ameliorates hepatic fibrosis via suppressing NF-κB pathway and promoting HSC apoptosis.

J Ethnopharmacol 2019 Apr 5:111856. Epub 2019 Apr 5.

Pharmacy College, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, PR China. Electronic address:

Ethnopharmacological Relevance: Pien Tze Huang (PZH), a Chinese herbal formula, has various forms of pharmacological activity including anti-inflammation, liver protection and anti-tumor.

Aim Of The Study: To investigate the anti-hepatic fibrosis effect of PZH and its potential mechanisms on experimental animal model of hepatic fibrosis and hepatic stellate cell (HSC).

Material And Methods: Rats were intraperitoneally administered with CCl to induce hepatic fibrosis and were simultaneously treated with PZH. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111856DOI Listing

Second exposure to acetaminophen overdose is associated with liver fibrosis in mice.

EXCLI J 2019 6;18:51-62. Epub 2019 Feb 6.

Molecular Hepatology Section, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, 68167-Mannheim, Germany.

Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the difference in response as a result of repeated exposures of acetaminophen (APAP) compared to a single dose is not well-studied. Therefore, in the current study, the liver response after a second dose of APAP was investigated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449668PMC
February 2019
2 Reads

Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis.

Nat Rev Rheumatol 2019 Apr 5. Epub 2019 Apr 5.

Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland.

Systemic sclerosis (SSc) is an autoimmune fibrotic disease of unknown aetiology that is characterized by vascular changes in the skin and visceral organs. Autologous haematopoietic stem cell transplantation can improve skin and organ fibrosis in patients with progressive disease and a high risk of organ failure, indicating that cells originating in the bone marrow are important contributors to the pathogenesis of SSc. Animal studies also indicate a pivotal function of myeloid cells in the development of fibrosis leading to changes in the tissue architecture and dysfunction in multiple organs such as the heart, lungs, liver and kidney. Read More

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http://dx.doi.org/10.1038/s41584-019-0212-zDOI Listing

Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis.

Ann Rheum Dis 2019 Apr 5. Epub 2019 Apr 5.

Division of Rheumatology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Objectives: Treatment of patients with systemic sclerosis (SSc) can be challenging because of clinical heterogeneity. Integration of genome-scale transcriptomic profiling for patients with SSc can provide insights on patient categorisation and novel drug targets.

Methods: A normalised compendium was created from 344 skin samples of 173 patients with SSc, covering an intersection of 17 424 genes from eight data sets. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214778DOI Listing

A non-autonomous role of MKL1 in the activation of hepatic stellate cells.

Biochim Biophys Acta Gene Regul Mech 2019 Apr 2;1862(6):609-618. Epub 2019 Apr 2.

Institute of Biomedical Research, Liaocheng University, Liaocheng, China; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China. Electronic address:

Although hepatic stellate cells (HSC) represent the major source of fibrogenesis in the liver under various pathological conditions, other cell types including hepatic parenchymal cells (hepatocytes) also contribute to HSC activation and hence liver fibrosis. The underlying mechanism, however, is poorly defined. Here we report that hepatocytes exposed to high concentrations of glucose (HG) emit a pro-fibrogenic cue as evidenced by the observation that primary HSCs cultured in conditioned media (CM) collected from hepatocytes exposed to HG up-regulated the production of extracellular matrix (ECM) proteins compared to CM collected from hepatocytes exposed to low glucose. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2019.03.001DOI Listing
April 2019
2 Reads

Potential Role of the Resident Mesenchymal Stem-Like Cells in Renal Fibrogenesis after Ureteral Obstruction.

Stem Cells Int 2019 5;2019:2543171. Epub 2019 Mar 5.

Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

The mechanisms of renal fibrogenesis after ureteral obstruction remain unclear. We tried to primarily expand mesenchymal stem cells from renal tissues and then investigated their role in fibrogenesis after ureteral obstruction. Unilateral ureteral obstruction was induced by ligating the left ureteral duct of adult C57BL/6 mice. Read More

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http://dx.doi.org/10.1155/2019/2543171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425387PMC

Autoimmune Hepatitis and Stellate Cells; an Insight into the Role of Autophagy.

Curr Med Chem 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology, Medical school of Shiraz University,Shiraz University of Medical Sciences,Shiraz. Iran.

Autoimmune hepatitis is a necroinflammatory process of liver, featuring interface hepatitis by T cells, macrophages and plasma cells that invade to periportal parenchyma. In this process a variety of cytokines is secreted and liver tissue undergoes fibrogenesis, that cause apoptosis of hepatocytes. Autophagy is a complementary mechanism for restraining intracellular pathogens to which the innate immune system does not provide an efficient endocytosis. Read More

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http://dx.doi.org/10.2174/0929867326666190402120231DOI Listing
April 2019
2 Reads
3.853 Impact Factor

Involvement of STAT3 Signaling in High Glucose-Induced Epithelial Mesenchymal Transition in Human Peritoneal Mesothelial Cell Line HMrSV5.

Kidney Blood Press Res 2019 Apr 3:1-9. Epub 2019 Apr 3.

Institute of Pharmacology, Anhui Medical University, Hefei, China.

Background/aims: Peritoneal fibrosis (PF) is a common complication in patients receiving long-term peritoneal dialysis, which results in damage to peritoneal functions. Epithelial-mesenchymal transition (EMT) is a key step in the early pathogenesis of PF. Increasing evidence has shown that signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in EMT and tissue fibrosis by interacting with distinct EMT-inducing molecules, including transforming growth factor (TGF)-β and advanced glycation end products (AGEs). Read More

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http://dx.doi.org/10.1159/000498965DOI Listing
April 2019
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Involvement of lncR-30245 in Myocardial Infarction-Induced Cardiac Fibrosis Through Peroxisome Proliferator-Activated Receptor-γ-Mediated Connective Tissue Growth Factor Signalling Pathway.

Can J Cardiol 2019 Apr 16;35(4):480-489. Epub 2019 Feb 16.

Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, P. R. China; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, P. R. China. Electronic address:

Background: Long noncoding RNAs (lncRNAs) are emerging as important mediators of cardiac pathophysiology. The aim of the present study is to investigate the effects of lncR-30245, an lncRNA, on cardiac fibrogenesis and the underlying mechanism.

Methods: Myocardial infarction (MI) and transforming growth factor (TGF)-β1 were used to induce fibrotic phenotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X193011
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http://dx.doi.org/10.1016/j.cjca.2019.02.005DOI Listing
April 2019
6 Reads

Novel Serum Biomarkers for Noninvasive Diagnosis and Screening of Nonalcoholic Fatty Liver Disease-Related Hepatic Fibrosis.

OMICS 2019 Apr 30;23(4):181-189. Epub 2019 Mar 30.

7 State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The Research Center for Clinical Pharmacy, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Nonalcoholic fatty liver disease (NAFLD) is a growing global public health concern and becoming the leading cause of liver disease worldwide. The estimated global prevalence of NAFLD is ∼25% depending on the country and the assessment method used to establish the diagnosis. Meta-analyses suggest that the highest prevalence is in the Middle East (31. Read More

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http://dx.doi.org/10.1089/omi.2019.0035DOI Listing
April 2019
2 Reads

miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis.

J Formos Med Assoc 2019 Mar 28. Epub 2019 Mar 28.

School of Dentistry, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

Background/purpose: Oral submucous fibrosis (OSF) is a precancerous condition of oral cancer with a complex etiology. Our previous work has demonstrated that non-coding RNA miR-1246 contributes to the cancer stemness of oral cancer. In the current study, we sought to investigate the effect of the inhibition of miR-1246 on the oral fibrogenesis. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.014DOI Listing
March 2019
2 Reads

TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.

EBioMedicine 2019 Mar 26. Epub 2019 Mar 26.

Department of Analytical Chemistry, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; E-Institute of Shanghai Municipal Education Committee, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. Electronic address:

Background: Hepatic stellate cell (HSC) activation induced by transforming growth factor β1 (TGF-β1) plays a pivotal role in fibrogenesis, while the complex downstream mediators of TGF-β1 in such process are largely unknown.

Methods: We performed pharmacoproteomic profiling of the mice liver tissues from control, carbon tetrachloride (CCl)-induced fibrosis and NPLC0393 administrated groups. The target gene MAT2A was overexpressed or knocked down in vivo by tail vein injection of AAV vectors. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.058DOI Listing
March 2019
1 Read

microRNA-21 expressions impact on liver fibrosis in biliary atresia patients.

BMC Res Notes 2019 Mar 29;12(1):189. Epub 2019 Mar 29.

Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Objective: Biliary atresia (BA) is the most common cause of neonatal jaundice, characterized by progressive and rapid liver fibrosis. Recent studies have shown that microRNAs (miRNAs) contribute to the liver fibrogenesis. We investigated the miRNA-21 impact in liver fibrogenesis in Indonesian BA patients. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441216PMC
March 2019
2 Reads

A panel of a mitogenic (PDGF), biochemical (albumin) and demographic (age) parameters for the noninvasive assessment of hepatic fibrosis.

Br J Biomed Sci 2019 Mar 29. Epub 2019 Mar 29.

e Faculty of medicine, department of endemic medicine and hepatology , Cairo University , Egypt.

Background: Several studies have investigated certain fibrosis markers that incorporate liver function tests, fragments of liver-matrix components, and/or degraded products generated by hepatic stellate cells for determining the degree of hepatic fibrosis. However, the role of these molecules in the development of hepatic fibrosis is unclear. This work aimed (a) to determine whether levels of platelet-derived growth factor (PDGF) are linked to different stages of hepatic fibrosis, and (b) investigate its diagnostic performance as an adjunct to other laboratory and demographic factors for assessing the degree of liver fibrosis in chronic hepatitis C infection. Read More

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March 2019
2 Reads

Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis.

PeerJ 2019 22;7:e6645. Epub 2019 Mar 22.

Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing, China.

Background: Liver fibrosis is often a consequence of chronic liver injury, and has the potential to progress to cirrhosis and liver cancer. Despite being an important human disease, there are currently no approved anti-fibrotic drugs. In this study, we aim to identify the key genes and pathways governing the pathophysiological processes of liver fibrosis, and to screen therapeutic anti-fibrotic agents. Read More

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http://dx.doi.org/10.7717/peerj.6645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432904PMC
March 2019
2 Reads

Chemokine (C-X-C motif) ligand 14 contributes to lipopolysaccharide-induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A.

J Cell Biochem 2019 Mar 28. Epub 2019 Mar 28.

Department of Respiratory Disease, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.

Herein, we found that serum chemokine ligand 14 (CXCL14) was significantly enhanced in patients with idiopathic pulmonary fibrosis (IPF). In our current study, mouse L929 fibroblasts were stimulated with lipopolysaccharide (LPS) (100 ng/mL). Cell proliferation, the levels of matrix metalloproteinase 2 (MMP2) and MMP9, as well as extracellular matrix (ECM) content were assessed to evaluate the fibrogenesis of L929 cells. Read More

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http://dx.doi.org/10.1002/jcb.28612DOI Listing
March 2019
1 Read
3.263 Impact Factor

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients.

J Lipid Res 2019 Mar 27. Epub 2019 Mar 27.

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Italy;

Dyslipidemia and altered iron metabolism are typical features of non-alcoholic fatty liver disease (NAFLD). Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) gene variation has been associated with circulating lipids and liver damage during iron overload. Aim of this study was to examine the impact of the PCSK7 rs236918 variant on NAFLD-related traits in 1,801 individuals from the Liver Biopsy Cohort (LBC), 500,000 from the UK Biobank Cohort (UKBBC), and 4,580 from the Dallas Heart Study (DHS). Read More

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http://www.jlr.org/lookup/doi/10.1194/jlr.P090449
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http://dx.doi.org/10.1194/jlr.P090449DOI Listing
March 2019
2 Reads

Inhibitory Effect of Sestrin2 on Hepatic Stellate Cell Activation and Liver Fibrosis via Blocking Transforming Growth Factor-β Signaling.

Antioxid Redox Signal 2019 Mar 26. Epub 2019 Mar 26.

Chosun University, College of Pharmacy , 375 Seosuk-dong , Donggu , Gwangju, Korea, Republic of ;

Aims: Hepatic fibrosis results from chronic liver injury and inflammatory responses. Sestrin2 (Sesn2), an evolutionarily conserved antioxidant enzyme, reduces the severities of acute hepatitis and metabolic liver diseases. However, the role of Sesn2 in the pathogenesis of liver fibrosis remains obscure. Read More

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https://www.liebertpub.com/doi/10.1089/ars.2018.7559
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http://dx.doi.org/10.1089/ars.2018.7559DOI Listing
March 2019
3 Reads

Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review.

Int J Mol Sci 2019 Mar 22;20(6). Epub 2019 Mar 22.

Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, Kofu, Yamanashi 4008506, Japan.

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and limited to the lungs. Despite the increasing research interest in the pathogenesis of IPF, unfavorable survival rates remain associated with this condition. Recently, novel therapeutic agents have been shown to control the progression of IPF. Read More

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http://dx.doi.org/10.3390/ijms20061461DOI Listing
March 2019
2 Reads

Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis.

J Am Chem Soc 2019 Apr 27;141(14):5593-5596. Epub 2019 Mar 27.

The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology , Massachusetts General Hospital (MGH) & Harvard Medical School (HMS) , Charlestown , Massachusetts 02129 , United States.

Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Read More

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http://dx.doi.org/10.1021/jacs.8b12342DOI Listing

Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.

J Immunol Res 2019 14;2019:7657294. Epub 2019 Feb 14.

Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, Hebei, China.

Macrophages are the master regulator of the dynamic fibrogenesis-fibrosis resolution paradigm. TNF-like ligand 1 aberrance (TL1A) was found to be able to induce intestinal inflammation and fibrosis. Furthermore, significantly increased TL1A had been detected in liver tissues and mononuclear cells of patients with primary biliary cirrhosis (PBC). Read More

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https://www.hindawi.com/journals/jir/2019/7657294/
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http://dx.doi.org/10.1155/2019/7657294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393882PMC
February 2019
5 Reads

MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta.

Mol Ther Nucleic Acids 2019 Feb 26;16:206-217. Epub 2019 Feb 26.

Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing 100069, China. Electronic address:

Here microRNAs (miRNAs) with potentially therapeutic effects were screened and explored during liver fibrogenesis and angiogenesis via targeting the important mediators. Chimera mice with EGFP bone marrow mesenchymal stromal cells (BMSCs) were fed with methionine-choline-deficient and high-fat (MCDHF) diet to induce liver injury. Increased expression of platelet-derived growth factor receptor-beta (PDGFR-β) was detected in MCDHF mice, with a positive correlation to fibrosis and angiogenesis markers. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426711PMC
February 2019
3 Reads

Green tea activity and iron overload induced molecular fibrogenesis of rat liver.

Saudi J Biol Sci 2019 Mar 18;26(3):531-540. Epub 2017 Aug 18.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Iron overload toxicity was shown to associate with chronic liver diseases which lead to hepatic fibrosis and subsequently the progression to cancer through oxidative stress and apoptotic pathways. Green tea potential activity as chelating, anti-oxidative, or anti-apoptotic mechanisms against metal toxicity was poorly clarified. Here, we are trying to evaluate the anti-oxidant and anti-apoptotic properties of green tea in the regulation of serum hepcidin levels, reduction in iron overloads, and improve of liver fibrosis in iron overloaded experimental rats. Read More

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http://dx.doi.org/10.1016/j.sjbs.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408694PMC
March 2019
1 Read

Sarcopenic obesity in fatty liver.

Curr Opin Clin Nutr Metab Care 2019 May;22(3):185-190

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Purpose Of Review: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato hepatitis have an increasing prevalence among liver diseases. Overweight and obesity are frequently associated conditions in patients with fatty liver. Skeletal muscle mass depletion may also coexist with chronic liver disease even in obese patients. Read More

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http://dx.doi.org/10.1097/MCO.0000000000000558DOI Listing
May 2019
1 Read

Targeted Drug Delivery to Hepatic Stellate Cells for the Treatment of Liver Fibrosis.

J Pharmacol Exp Ther 2019 Mar 18. Epub 2019 Mar 18.

University of Missouri-Kansas City

Liver fibrosis is caused by excessive accumulation of extracellular matrix during chronic liver injuries. Although clinical evidences suggest that liver fibrosis can be reversed, there is no standard therapy for liver fibrosis. Moreover, there is a lack of diagnostic tools to detect early-stage liver fibrosis. Read More

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http://dx.doi.org/10.1124/jpet.118.256156DOI Listing
March 2019
1 Read

Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition.

Int J Mol Sci 2019 Mar 16;20(6). Epub 2019 Mar 16.

School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan.

Oral submucous fibrosis (OSF) is an oral precancerous condition associated with the habit of areca nut chewing and the TGF-β pathway. Currently, there is no curative treatment to completely heal OSF, and it is imperative to alleviate patients' symptoms and prevent it from undergoing malignant transformation. Arctigenin, a lignan extracted from , has been reported to have a variety of pharmacological activities, including anti-fibrosis. Read More

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http://dx.doi.org/10.3390/ijms20061328DOI Listing

Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats.

Environ Toxicol Pharmacol 2019 May 8;68:109-119. Epub 2019 Mar 8.

Institute of Clinical Pharmacology of Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine of Education Ministry, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, 230032, Anhui, China. Electronic address:

Di(2-ethylhexyl) phthalate (DEHP) is an environmental pollutant that is widely used in medical and consumer products. An epidemiological study has suggested that a large daily intake of DEHP from phthalate-contaminated food may be a risk factor for liver dysfunction. Long-term exposure to DEHP is associated with liver disease and exacerbates the progression of chronic liver injury. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.008DOI Listing

Bone morphogenetic protein-6 inhibits fibrogenesis in scleroderma offering new treatment options of fibrotic skin disease.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Biochemistry, Emil-Fischer-Center, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany. Electronic address:

Bone morphogenetic protein-6 (BMP6) is known to be crucial for regulating embryonic skin development. This study assessed the role of BMP6 in dermal fibrosis. We detected that BMP6 is significantly increased in skin-derived fibroblasts of patients with localized scleroderma. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.020DOI Listing

Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway.

Biomed Pharmacother 2019 May 13;113:108705. Epub 2019 Mar 13.

Pharmaceutical College, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address:

Background: Hyperglycemia stimulated epithelial-mesenchymal transition (EMT) plays a critical role in initiating and progressing renal fibrosis in diabetic kidney disease (DKD). It is crucial to explore novel renal protective drugs for the treatment of DKD.

Objective: The present study is to confirm our hypothesis and to accumulate the information for the application of DMDD (2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione) as a novel therapeutic agent to potentially inhibit renal fibrogenesis and EMT in the DKD. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108705DOI Listing

Ischemic Duration and Frequency Determines AKI-to-CKD Progression Monitored by Dynamic Changes of Tubular Biomarkers in IRI Mice.

Front Physiol 2019 26;10:153. Epub 2019 Feb 26.

Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Ischemia reperfusion injury (IRI) is one of the most common causes of acute kidney injury (AKI). However, the pathogenesis and biomarkers predicting the progression of IRI-induced AKI to chronic kidney disease (CKD) remain unclear. A side-by-side comparison between different IRI animal models with variable ischemic duration and episodes was performed. Read More

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http://dx.doi.org/10.3389/fphys.2019.00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401609PMC
February 2019
1 Read

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension.

Gastroenterology 2019 Mar 11. Epub 2019 Mar 11.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester MN, USA.

Background & Aims: Mechanical forces contribute to portal hypertension (PHTN) and fibrogenesis. We investigated the mechanisms by which forces are transduced by liver sinusoidal endothelial cells (LSECs) into pressure and matrix changes.

Methods: We isolated primary LSECs from mice and induced mechanical stretch with a Flexcell device, to recapitulate the pulsatile forces induced by congestion, and performed microarray and RNA-sequencing analyses to identify gene expression patterns associated with stretch. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.013DOI Listing
March 2019
4 Reads
16.716 Impact Factor

Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis.

Allergol Int 2019 Mar 11. Epub 2019 Mar 11.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Periostin is an established biomarker of Th2 immune response and fibrogenesis. Recent research has indicated that periostin plays an important role in the pathogenesis of idiopathic interstitial pneumonias. To clarify the relationship between periostin and pathogenesis in chronic bird-related hypersensitivity pneumonitis (HP) and to reveal the usefulness of serum periostin levels in diagnosing and managing chronic bird-related HP. Read More

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http://dx.doi.org/10.1016/j.alit.2019.02.007DOI Listing
March 2019
2 Reads