201,851 results match your criteria Fever of Unknown Origin


Overcoming the challenges of pen-side molecular diagnosis of African swine fever to support outbreak investigations under field conditions.

Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.

National Veterinary Institute, Uppsala, Sweden.

African swine fever (ASF) is a devastating disease of pigs. Without a vaccine, early detection and rapid diagnosis of ASF is a crucial step towards effective disease control. In many countries where ASF is endemic, laboratory infrastructure including sampling and sample shipment is inadequate, and a rapid laboratory confirmation would require that the diagnosis is performed at regional laboratories close to the pig farms of concern, or even at the farm-side. Read More

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December 2018

A new approach of assessing patient safety aspects in routine practice using the example of "doctors handwritten prescriptions".

J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.

Research Unit for Safety in Health, c/o Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Austria.

Aims And Objectives: The aim of this study was to test the method of self- and external assessment as a feedback system to decrease illegibility and incorrectness of handwritten prescriptions and to reduce additional workload for nursing staff.

Background: Illegibility and incorrectness of handwritten prescriptions occur very often and are the most crucial factors affecting patient safety.

Design: Self- versus external assessment using a 15 items checklist. Read More

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December 2018

Giant-cell arteritis without cranial manifestations presenting as fever of unknown origin: a diagnostic value of 18F-FDG PET/CT.

Clin Ter 2018 Nov-Dec;169(6):e274-e276

Department of Infectious Diseases, Military Medical Academy, Sofia, Bulgaria.

We present a case of 68-year-old female with four months history of fever, fatigue, and weight loss. She was classified as case of fever of unknown origin. The physical examination was normal, the laboratory tests showed anemia, elevation of C-reactive protein, erythrocyte sedimentation rate and fibrinogen. Read More

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December 2018
3 Reads

Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

S.R. Johnson MD PhD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. D. Khanna MD MS, Division of Rheumatology, Department of Medicine, University of Michigan, USA. R. Cervera MD PhD FRCP, Hospital Clínic, Barcelona, Spain. N. Costedoat-Chalumeau MD PhD AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris, France ; Université Paris Descartes-Sorbonne Paris Cité, Paris, France ; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. D.D. Gladman MD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. B.H. Hahn MD, University of California Los Angeles, Los Angeles, USA. F. Hiepe MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. J. Sánchez-Guerrero MD MSc, Division of Rheumatology, Department of Medicine Mount Sinai Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada; and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. E. Massarotti MD, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston, USA. D.T. Boumpas MD FACP FACR, National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece. K.H Costenbader MD MPH, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, USA. D. Daikh MD, University of California, San Francisco, USA. D. Jayne MD FRCP FRCPE FMedSci, Department of Medicine, University of Cambridge, United Kingdom. T. Dörner MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. D.L. Kamen MD MSCR, Medical University of South Carolina, Charleston, USA. M. Mosca MD PhD, University of Pisa, Italy. R. Ramsey-Goldman MD DrPH, Northwestern University Feinberg School of Medicine, Chicago, USA. J.S. Smolen MD, Medical University of Vienna, Austria. D. Wofsy MD, University of California, San Francisco, USA. M. Aringer MD, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. Address correspondence to Sindhu Johnson MD PhD, Division of Rheumatology, Ground Floor, East Wing, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8. Phone 1-416-603-6417 Fax.1-416-603- 4348. Email:

Objective: Given the complexity and heterogeneity of systemic lupus erythematosus (SLE), high performing classification criteria are critical to advancing research and clinical care. A collaborative effort by EULAR and ACR was undertaken to generate candidate criteria, and then to reduce them to a smaller set. The objective of the current study was to select a set of criteria that maximizes the likelihood of accurate classification of SLE, particularly early disease. Read More

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December 2018

Genetic diversity of Culicoides species within the Pulicaris complex (Diptera: Ceratopogonidae) in Turkey inferred from mitochondrial COI gene sequences.

Acta Trop 2018 Dec 13. Epub 2018 Dec 13.

Erciyes University, Faculty of Veterinary Medicine, Parasitology Department, Kayseri, Turkey; Vectors and Vector-Borne Diseases Implementation and Research Center, Erciyes University, Kayseri, Turkey.

Identification of Culicoides (Diptera: Ceratopogonidae) biting midges to species has become important due to their potential role in the transmission of arboviruses such as bluetongue virus, bovine ephemeral fever virus, Akabane virus, African horse sickness virus, epizootic haemorrhagic disease virus and Schmallenberg virus. In several studies, molecular tools, used for the identification of biting midges, revealed the presence of cryptic and undescribed species especially within Pulicaris complex. The presence of cryptic species within species complexes raise questions about their role in viral disease transmission as there are apparent differences in the vectorial capacity between closely related species. Read More

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December 2018

An unusual case of gastrointestinal basidiobolomycosis mimicking colon cancer; literature and review.

J Mycol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Mycology/Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Gastrointestinal basidiobolomycosis (GIB), a rare fungal infection associated with high mortality, has been reported worldwide mainly from tropical and subtropical regions of Asia, USA, and Latin America. The clinical manifestations are highly diverse and non-specific depending on the underlying disease, but fever, abdominal pain, weight loss, diarrhea, constipation and chills have been observed. There are no prominent risk factors for GIB but climatic conditions and life style are related to this infection in arid and semi-arid regions. Read More

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December 2018

ARBOVIRUS INVESTIGATION IN PATIENTS FROM MATO GROSSO DURING ZIKA AND CHIKUNGUNYA VIRUS INTRODUTION IN BRAZIL, 2015-2016.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Programa de Pós-Graduação em Ciências da Saúde, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Av. Fernando Correa da Costa, n. 2367, CCBS-I, sala 82, CEP 78060-900, Cuiabá, Mato Grosso, Brazil. Electronic address:

Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) during the period of ZIKV and CHIKV dissemination in Brazil. To achieve that, 453 human serum samples of patients suspected of Dengue (DENV), Yellow Fever (YFV), ZIKV or CHIKV collected in health units of 31 cities of MT were subjected to RT-PCR protocols for 10 flaviviruses, 5 alphaviruses and orthobunyaviruses from Simbu serogroup, nucleotide sequencing and viral isolation. Read More

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December 2018
2 Reads

What's new in autoinflammation?

Authors:
Seza Ozen

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

The pathogenesis of autoinflammatory diseases has shed light on the concept of inflammation in general and on our understanding of the role of the innate immune system. The autoinflammatory diseases have a large spectrum with varying features of inflammation. The most common autoinflammatory diseases are those associated with periodic fevers. Read More

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December 2018
1 Read

Proteins, transcripts, and genetic architecture of seminal fluid and sperm in the mosquito .

Mol Cell Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Biology & Biochemistry, Syracuse University, United States of America

The yellow fever mosquito, , transmits several viruses causative of serious diseases, including dengue, Zika, and chikungunya. Some proposed efforts to control this vector involve manipulating reproduction to suppress wild populations or to replace them with disease-resistant mosquitoes. The design of such strategies requires an intimate knowledge of reproductive processes, yet our basic understanding of reproductive genetics in this vector remains largely incomplete. Read More

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December 2018
1 Read

F-FDG-PET/CT-guided treatment duration in patients with high-risk Staphylococcus aureus bacteremia: a proof of principle.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Dept of Internal Medicine & Radboud Center for Infectious Diseases, Radboud university medical ctr.

Current guidelines recommend intravenous antibiotic therapy for at least 4 weeks in patients with high-risk Staphylococcus aureus bacteremia (SAB), because of the risk for metastatic infection. We evaluated the safety of shorter duration of treatment in patients with high-risk SAB without signs of metastatic infection at presentation, using standard F-FDG PET/CT and echocardiography. Retrospective analyses were performed of patients with SAB admitted between 2013 and 2017 in two medical centers. Read More

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December 2018

Postdischarge Mortality Prediction in Sub-Saharan Africa.

Pediatrics 2018 Dec 14. Epub 2018 Dec 14.

Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique;

Background: Although the burden of postdischarge mortality (PDM) in low-income settings appears to be significant, no clear recommendations have been proposed in relation to follow-up care after hospitalization. We aimed to determine the burden of pediatric PDM and develop predictive models to identify children who are at risk for dying after discharge.

Methods: Deaths after hospital discharge among children aged <15 years in the last 17 years were reviewed in an area under demographic and morbidity surveillance in Southern Mozambique. Read More

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December 2018

[Sweet's syndrome induced by pegfilgrastim during a myelodysplastic syndrome AREB2: A case report].

Rev Med Interne 2018 Dec 11. Epub 2018 Dec 11.

Service d'hématologie-oncologie, CHU Brugmann, 4, place Arthur Van Gehuchten, 1020 Bruxelles, Belgique.

Introduction: Sweet's syndrome is an acute neutrophilic dermatosis characterized by abrupt onset of skin lesions accompanied by fever, arthralgia, leukocytosis and diffuse neutrophilic infiltration of the dermis, as well as an excellent response to corticosteroid therapy.

Case Report: A 46-year-old patient with myelodysplastic syndrome was admitted for chemotherapy. On the eighth day of chemotherapy, he received a single dose of pegfilgrastim. Read More

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December 2018
2 Reads

Frequency of Adverse Events Following Q Fever Immunisation in Young Adults.

Vaccines (Basel) 2018 Dec 13;6(4). Epub 2018 Dec 13.

National Centre for Immunisation Research and Surveillance, Westmead, NSW 2145, Australia.

Q fever is a zoonosis of concern in many countries. Vaccination is the most effective means of prevention, and since 1989, Australia has had a licensed Q fever vaccine, Q-VAX. This vaccine was also used in the Netherlands in 2011 following the largest recorded Q fever outbreak globally. Read More

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December 2018

Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Filoviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleoprotein (NP), viral protein 35 (VP35), viral protein 30 (VP30) and large protein (L). Read More

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December 2018

West Nile virus epizootic in Germany, 2018.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Greifswald-Insel Riems, Germany. Electronic address:

The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered the further expansion and the efficient propagation of the zoonotic arthropod-borne West Nile virus in many Southern/Southeastern and even Central European countries. WNV infections were detected for the first time in resident wild and aviary birds, such as common blackbirds, northern goshawks and great grey owls in Eastern and Southeastern Germany. Read More

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December 2018

Risk Factors for Severe Dry Eye Disease: Crowdsourced Research Using DryEyeRhythm.

Ophthalmology 2018 Dec 11. Epub 2018 Dec 11.

Juntendo University Faculty of Medicine, Department of Ophthalmology, Tokyo Japan.

This large-scale crowdsourced study using the iPhone application DryEyeRhythm identified the risk factors for severe dry eye disease-type symptoms, which included female sex, collagen disease, hay fever, depression, current contact-lens use, extended screen time, and smoking. Read More

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December 2018
1 Read

Economic impact of dengue in Mexico considering reported cases for 2012 to 2016.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

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December 2018

[The clinical laboratory characteristic of primary acute cytomegalovirus infection in non-immunocompromised adult patients].

Klin Lab Diagn 2018 ;63(1):51-54

The state budget institution of health care "The clinical center of prevention and struggle with AIDS" of the Minzdrav of the Krasnodar kraii, 350015, Krasnodar, Russia.

The purpose of study is the clinical laboratory characteristic of acquired acute cytomegalovirus infection in nonimmunocompromised adult patients. The sampling included 75 patients with acquired acute cytomegalovirus infection admitted to the specialized clinical infection hospital of the Minzdrav of the Krasnodar kraii. The verifcation of diagnosis was implemented using serological tests and polymerase chain reaction. Read More

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January 2018
1 Read

Clinical, Epidemiological, and Etiological Changes in Erythema Nodosum.

Isr Med Assoc J 2018 Dec;20(12):770-772

Department of Internal Medicine F, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Erythema nodosum (EN) is the most common type of panniculitis, commonly secondary to infectious diseases.

Objectives: To elucidate the causative factors and the clinical presentation of patients with EN (2004-2014) and to compare their data to those reported in a previous study.

Methods: A retrospective study was conducted of all patients diagnosed with EN who were hospitalized at Soroka University Medical Center (2004-2014). Read More

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December 2018

Tetanus outbreak in a sheep flock due to ear tagging.

Vet Med Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Tetanus is an acute, often fatal, infectious neuromuscular disease in all farmed mammals caused by Clostridium tetani. The disease is sporadic but outbreaks of tetanus have been described, as a result of wound contaminated with spores of C. tetani, which sporulates to the vegetative form and produce toxins. Read More

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December 2018

Re-emergence of genotype I of African swine fever virus in Ivory-Coast.

Transbound Emerg Dis 2018 Dec 12. Epub 2018 Dec 12.

Animal Production and Health Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Wagramer Strasse 5, P.O. Box 100, A-1400, Vienna, Austria.

In July 2014, an outbreak of severe hemorrhagic disease in a domestic pig population, was reported in San-Pedro, the second seaport city of Ivory-Coast. Animals of all age groups developed clinical signs consistent with African swine fever (ASF). Tissue and serum samples from dead pigs were sent to the laboratory for diagnostic confirmation and molecular characterization based on the partial B646L (p72), the full E183L (p54) gene and the central variable region of the B602L gene. Read More

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December 2018

Unusual Presentation of Q Fever in a Kidney-Pancreas Transplant Recipient.

Transpl Infect Dis 2018 Dec 12:e13037. Epub 2018 Dec 12.

Division of Infectious Diseases, Carver College of Medicine University of Iowa, Iowa City, IA, USA.

Q fever is uncommon in solid organ transplant (SOT) recipients. We describe a case of granulomatous lung disease as an unusual presentation of chronic Q fever in a kidney-pancreas transplant recipient. This article is protected by copyright. Read More

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December 2018

Incidence, Causes, and Correlates of Maternal Near-Miss Morbidity: a multi-centre cross-sectional study.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

University of Michigan, Ann Arbor, Michigan, USA.

Objective: To explore the incidence and factors associated with maternal near-miss.

Design: Cross-sectional study with an embedded case-control study.

Setting: Three tertiary referral hospitals in southern Ghana. Read More

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December 2018

Chikungunya Virus: History, Geographic Distribution, Clinical Picture, and Treatment.

P R Health Sci J 2018 Dec;37(4):187-194

Third-year medical student, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Chikungunya fever (CHIKF) is a re-emerging mosquito-borne disease caused by a virus endemic to Africa and Asia. Due to the ease with which its vectors propagate, the virus has spread to India and Europe, and more recently it arrived to the Caribbean, eventually extending into North, Central, and South America. According to the World Health Organization (WHO), the most common clinical manifestations are abrupt fever, polyarthralgia, headache, maculopapular rash, myalgia, and nausea/vomiting. Read More

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December 2018

Genetic variability of the Aedes aegypti (Diptera: Culicidae) mosquito in El Salvador, vector of dengue, yellow fever, chikungunya and Zika.

Parasit Vectors 2018 Dec 14;11(1):637. Epub 2018 Dec 14.

Departmento de Biología, Universidad de El Salvador, Final de Av. Mártires y Héroes del 30 Julio, San Salvador, El Salvador.

Background: Aedes aegypti is associated with dengue, yellow fever, chikungunya and Zika viruses. This vector is widespread in tropical and subtropical areas, and can also occur in temperate areas at higher latitudes. The geographical distribution of Ae. Read More

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December 2018

Intra-epidemic genome variation in highly pathogenic African swine fever virus (ASFV) from the country of Georgia.

Virol J 2018 Dec 14;15(1):190. Epub 2018 Dec 14.

Laboratory of the Ministry of Agriculture, Tbilisi, Georgia.

Background: African swine fever virus (ASFV) causes an acute hemorrhagic infection in suids with a mortality rate of up to 100%. No vaccine is available and the potential for catastrophic disease in Europe remains elevated due to the ongoing ASF epidemic in Russia and Baltic countries. To date, intra-epidemic whole-genome variation for ASFV has not been reported. Read More

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December 2018

Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana.

Malar J 2018 Dec 14;17(1):468. Epub 2018 Dec 14.

Worldwide Universities Network, University of Ghana, P.O. Box LG 13, Legon, Accra, Ghana.

Background: This study seeks to compare the performance of HRP2 (First Response) and pLDH/HRP2 (Combo) RDTs for falciparum malaria against microscopy and PCR in acutely ill febrile children at presentation and follow-up.

Methods: This is an interventional study that recruited children < 5 years who reported to health facilities with a history of fever within the past 72 h or a documented axillary temperature of 37.5 °C. Read More

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December 2018

Leptotrichia trevisanii bacteremia in a woman with systemic lupus erythematosus receiving high-dose chemotherapy.

BMC Infect Dis 2018 Dec 14;18(1):661. Epub 2018 Dec 14.

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1095#, Wuhan, 430030, China.

Background: Leptotrichia species are aerotolerant, Gram-negative fusiform bacteria. Cases of bacteremia caused by Leptotrichia trevisanii in immunocompromised patients have been rarely reported.

Case Presentation: A 33-year-old female with systemic lupus erythematosus (SLE) was admitted to the department of rheumatology with bleeding from a mucosal ulcer. Read More

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December 2018
1 Read

In Silico Characterization of B Cell and T Cell Epitopes for Subunit Vaccine Design of Salmonella typhi PgtE: A Molecular Dynamics Simulation Approach.

J Comput Biol 2018 Dec 14. Epub 2018 Dec 14.

4 Data Mining and Text Mining Laboratory, Department of Bioinformatics, Bharathiar University , Coimbatore, India .

Typhoid fever is an acute illness in humans, caused by Salmonella typhi, a gram-negative bacterium. Outer membrane proteins of S. typhi have strong potential for its use in the development of subunit vaccine against typhoid. Read More

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December 2018

Efficacy of Telephone Follow-Up in Children Tonsillectomy with Day Surgery.

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of ENT, Affiliated Renhe Hospital of China, Three Gorges University, Second Clinical Medical College of China, No. 410 Yiling Road, Yi Chang, Hubei, China.

Objective: Day surgery for tonsillectomy has become more and more popular in China. However, many parents face difficulties to cope up with the pain and side effects after surgery. The present study was aimed to examine the efficacy of telephone follow-up on children's post-discharge recovery after tonsillectomy. Read More

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December 2018
1 Read

A Rare Case of Laryngopyocele with Airway Obstruction.

J Clin Imaging Sci 2018 15;8:42. Epub 2018 Nov 15.

Department of Radiology, Tuen Mun Hospital, Tuen Mun, Hong Kong.

Laryngocele is a rare entity and can be defined as an abnormal cystic dilatation of saccule of the laryngeal ventricle with communication to the lumen of larynx. Laryngopyocele is a rare complication of laryngocele when it is infected. Patients may present with fever, neck swelling, shortness of breath, and hoarseness. Read More

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November 2018

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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November 2018
1 Read

Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report.

Oncol Lett 2018 Dec 1;16(6):6998-7007. Epub 2018 Oct 1.

Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong 518120, P.R. China.

This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. Read More

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December 2018
0.987 Impact Factor

Rare case of idiopathic sclerosing cholangitis, which was difficult to distinguish from cholangiocarcinoma: A case report.

Exp Ther Med 2018 Dec 5;16(6):5224-5226. Epub 2018 Oct 5.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.

It is often difficult to correctly diagnose patients who present with dilation of the bile duct. Cholangiocarcinoma, primary sclerosing cholangitis (PSC) and immunoglobulin (Ig)G4-related sclerosing cholangitis must be considered as potential diagnoses for these cases. The current study presents a 73-year-old female patient who presented with a high fever and abdominal pain. Read More

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December 2018

Treatment with a 5-day versus a 10-day schedule of decitabine in older patients with newly diagnosed acute myeloid leukaemia: a randomised phase 2 trial.

Lancet Haematol 2018 Dec 10. Epub 2018 Dec 10.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Hypomethylating agents, such as decitabine, are the standard of care for older patients with newly diagnosed acute myeloid leukaemia. Single-arm studies have suggested that a 10-day schedule of decitabine cycles leads to better outcomes than the usual 5-day schedule. We compared the efficacy and safety of these two schedules. Read More

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December 2018

Cardiac Involvement by Yellow Fever(from the PROVAR+ Study).

Am J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Serviço de Cardiologia e Cirurgia Cardiovascular e Centro de Telessaúde do Hospital das Clínicas da UFMG, Belo Horizonte, Minas Gerais, Brazil; Departamento de Clínica Médica, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Incidence of Yellow Fever (YF) has increased in Brazil, and cardiac findings such as bradyarrhythmias and conduction abnormalities have been described. We aimed to perform a comprehensive cardiac evaluation of patients with YF, and to assess the association between cardiac involvement and disease severity. Patients hospitalized with YF from February to March 2018 underwent clinical and laboratory evaluation, focused bedside echocardiography (GE Vivid IQ), electrocardiogram and, in case of alterations, 24-hours Holter. Read More

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December 2018
1 Read

Diversity of Rickettsia species in border regions of northwestern China.

Parasit Vectors 2018 Dec 13;11(1):634. Epub 2018 Dec 13.

Department of Basic Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, Uygur Autonomous Region, China.

Background: Rickettsia species belonging to the spotted fever group (SFG) cause infections in humans, domestic animals and wildlife. At least ten SFG Rickettsia species are known to occur in China. However, the distribution of rickettsiae in ticks and fleas in the border region of northwestern China have not been systematically studied to date. Read More

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December 2018

RVFV Infection in Goats by Different Routes of Inoculation.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.

Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. Infection causes abortions in pregnant animals, high mortality in neonate animals, and mild to severe symptoms in both people and animals. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. Read More

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December 2018

Host-Driven Phosphorylation Appears to Regulate the Budding Activity of the Lassa Virus Matrix Protein.

Pathogens 2018 Dec 9;7(4). Epub 2018 Dec 9.

Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, VT 05405, USA.

Lassa mammarenavirus (LASV) is an enveloped RNA virus that can cause Lassa fever, an acute hemorrhagic fever syndrome associated with significant morbidity and high rates of fatality in endemic regions of western Africa. The arenavirus matrix protein Z has several functions during the virus life cycle, including coordinating viral assembly, driving the release of new virus particles, regulating viral polymerase activity, and antagonizing the host antiviral response. There is limited knowledge regarding how the various functions of Z are regulated. Read More

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December 2018

Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus.

Viruses 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Pathology and Laboratory Medicine, University of Wisconsin⁻Madison, Madison, WI 53711, USA.

Simarteriviruses (: ) are commonly found at high titers in the blood of African monkeys but do not cause overt disease in these hosts. In contrast, simarteriviruses cause severe disease in Asian macaques upon accidental or experimental transmission. Here, we sought to better understand the host-dependent drivers of simarterivirus pathogenesis by infecting olive baboons (n = 4) and rhesus monkeys (n = 4) with the simarterivirus Southwest baboon virus 1 (SWBV-1). Read More

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December 2018

HPLC-ESI-MS/MS Profiling of Polyphenolics of a Leaf Extract from (Zingiberaceae) and Its Anti-Inflammatory, Anti-Nociceptive, and Antipyretic Activities In Vivo.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 44883-2462 Heidelberg, Germany.

Reactive oxygen species (ROS) have been linked to several health conditions, among them inflammation. Natural antioxidants may attenuate this damage. Our study aimed to investigate the chemical composition of a methanol leaf extract from and its possible antioxidant, anti-inflammatory, anti-nociceptive, and antipyretic effects. Read More

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December 2018

Myocardial calcification found in Epstein-Barr viral myocarditis and rhabdomyolysis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13582

Department of Critical Care Medicine, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, China.

Rationale: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis.

Patient Concerns: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. Read More

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December 2018

Hyperamylasemia may indicate the presence of ovarian carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

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December 2018
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Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13243

Institute for Applied Epistemology and Medical Methodology (IFAEMM) at the University of Witten/Herdecke, Freiburg i. Brsg., Germany.

Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)-widely used as an adjunct to cancer treatment-have cytotoxic, apoptogenic, and immune stimulatory properties. Read More

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December 2018
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Obesity and risk of urinary tract infection in young children presenting with fever.

Medicine (Baltimore) 2018 Dec;97(49):e13006

Department of Pediatrics, Tri-Service General Hospital, Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.

Obesity may increase the risk of infection, but the association between obesity and febrile urinary tract infection (fUTI) is controversial. Although the prevalence of infant and childhood obesity has been increasing worldwide, the results of previous investigations on the association with urinary tract infection (UTI) are conflicting. The purpose of this study was to evaluate the relationship between overweight and obesity and UTI in febrile children. Read More

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December 2018

Autopsing history: The mummy of Charlemagne (c. 747 - 814 AD), father of Europe.

Econ Hum Biol 2018 Nov 27;32:11-17. Epub 2018 Nov 27.

Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

In this article, a complete history of Charlemagne's mortal remains is outlined, including the first publication reporting on the most recent tomb opening in 1988. Besides exclusive bioarchaeological details - namely that his body was indeed mummified - a full clinical interpretation of the Emperor's final illnesses and death is given: a likely combination of osteoarthritis, gout and a recurrent fever caused by an infectious disease. Read More

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November 2018

Chronic Q fever-related complications and mortality: data from a nationwide cohort.

Clin Microbiol Infect 2018 Dec 10. Epub 2018 Dec 10.

University Medical Centre Utrecht, Utrecht, The Netherlands.

Objectives: Chronic infection with Coxiella burnetii (chronic Q fever) can cause life threatening conditions such as endocarditis, infected vascular prostheses and infected arterial aneurysms. We aimed to assess prognosis of chronic Q fever patients in terms of complications and mortality.

Methods: A large cohort of chronic Q fever patients was assessed to describe complications, overall mortality and chronic Q fever-related mortality. Read More

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December 2018

Role of Adverse Events in Unscheduled Hospitalizations Among Patients With Solid Tumors Who Receive Medical Oncology Treatment.

J Oncol Pract 2018 Dec 13:JOP1800319. Epub 2018 Dec 13.

Dana-Farber Cancer Institute; Boston Children's Hospital; Beth Israel Deaconess Medical Center, and Boston University School of Public Health, Boston, MA.

Purpose:: The development of strategies to prevent or mitigate cancer treatment-related adverse events (AEs) is necessary to improve patient experience, safety, and cost containment. To develop a strategy to easily identify and mitigate AEs, we sought to understand the frequency and severity of those that resulted in hospitalizations.

Methods:: We retrospectively characterized hospitalizations of ambulatory adult patients with solid tumor cancers within 30 days of chemotherapy administration using medical record data abstraction. Read More

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December 2018

Genetically modified pigs are protected from classical swine fever virus.

PLoS Pathog 2018 Dec 13;14(12):e1007193. Epub 2018 Dec 13.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, College of Animal Sciences, Jilin University, 130062, Changchun, Jilin Province, People's Republic of China.

Classical swine fever (CSF) caused by classical swine fever virus (CSFV) is one of the most detrimental diseases, and leads to significant economic losses in the swine industry. Despite efforts by many government authorities to stamp out the disease from national pig populations, the disease remains widespread. Here, antiviral small hairpin RNAs (shRNAs) were selected and then inserted at the porcine Rosa26 (pRosa26) locus via a CRISPR/Cas9-mediated knock-in strategy. Read More

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December 2018

Epidemiology of lumbar punctures in hospitalized patients in the United States.

PLoS One 2018 13;13(12):e0208622. Epub 2018 Dec 13.

Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama, United States of America.

Objectives: Lumbar puncture (LP) is an important technique for assessing and treating neurological symptoms. The objective of this study was to describe the characteristics of diagnostic lumbar punctures performed on hospitalized patients in the United States.

Methods: We analyzed data from the 2010 National Inpatient Sample (NIS) and the National Emergency Department Survey (NEDS). Read More

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December 2018
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