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Clin Rheumatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Internal Medicine, Division of Rheumatology, Hacettepe University Medical School, Sihhiye, 06100, Ankara, Turkey.

The author regrets that the original version of this article contained error. Figure 1 was shown in the wrong version, thus corrected figure is shown in this article. Read More

Clin Lab 2019 Jan;65(1)

Background: Fever of unknown origin (FUO) is one of the greatest challenges for clinicians and patients. There are more than 200 etiological agents of FUO, among these the most common is the role of infection, neoplasms, and diseases of connective tissue. The aim of the present study is to investigate the role of the infectious agents parvovirus B19 (B19V) and Coxiella burnetii (C. Read More

Clin Infect Dis 2019 Feb;68(Supplement_1):S10-S15

Department of Medicine, University of Cambridge, United Kingdom.

Background: Salmonella infections cause a disproportionately high number of deaths in Africa, especially among poor urban populations. The increasing level of multidrug-resistant (MDR) infections is a major cause of concern in these settings where alternative effective treatment is unavailable. Other options for management of these infections must be sought. Read More

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Clinics of Nuclear Medicine, and.

Unexpected inflammatory activity of tumoral calcinosis periarticular to the shoulders and hips in a man with recurrent fever of unknown origin and dialysis-dependent kidney insufficiency was revealed by FDG PET/CT. In absence of other pathologies, the calcinosis was deemed to be the cause of the fever. An infectious or malignant disease could be ruled out, so further therapeutic steps were enabled. Read More

Internist (Berl) 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Infektiologie und Spitalhygiene, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz.

A patient with acute myeloid leukemia developed disseminated tuberculosis with cerebral involvement in the early phase of induction chemotherapy before allogenic stem cell transplantation. He presented with persisting fever of unknown origin, and initially misinterpreted organ lesions in CT scans. Read More

Dermatol Ther 2019 Feb 13:e12860. Epub 2019 Feb 13.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul.

Pemphigus vulgaris (PV) is an autoimmune blistering skin disease that, may require multiagent immunosuppressive drug therapies in severe cases. In addition to the well established corticosteroid sparing agents azathioprine, mycophenolate mofetil, and methotrexate, rituximab is being increasingly used alone or in combination in the management of PV. Due to the chronic course of the disease, the cumulative effects of these therapy agents over long follow-up periods may result in various adverse reactions, including bacterial and viral infections. Read More

Eur J Case Rep Intern Med 2019 10;6(1):001023. Epub 2019 Jan 10.

Department of Medicine, Hospital Pedro Hispano, Unidade Local de Saúde Matosinhos, Matosinhos, Portugal.

We report a clinical case of adult-onset Still's disease. In addition to the imaging features of the case, the following aspects are also briefly described: clinical presentation (prolonged fever associated with migratory polyarthritis and skin rash), treatment performed (resort to anti-inflammatory and corticoid), and clinical evolution of the patient after having performed the adult-onset. The treatment was found to be appropriate as the patient presented a favourable clinical evolution. Read More

Eur J Case Rep Intern Med 2018 27;5(9):000881. Epub 2018 Sep 27.

Department of Internal Medicine, Centro Hospitalar Conde São Januário, Macau SAR.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory condition characterized by tumefactive lesions that can affect multiple organs. Serum IgG4 levels may be elevated. Early recognition is sometimes difficult but is important to avoid irreversible organ damage. Read More

Eur J Case Rep Intern Med 2018 22;5(2):000772. Epub 2018 Feb 22.

Haematology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.

We present the case of a 70-year-old male patient with fever of unknown origin after a long period of convalescence from a previous admission to a chronic care hospital. During the admission, multiple combinations of antibiotic and antifungal treatments were prescribed, but with persistent fever and, eventually, neutropenia (200 lymphocytes, 0 neutrophils). Given the suspicion of infection at bone marrow level, a biopsy was performed as was serology of , both diagnostic determinations. Read More

Asia Pac Allergy 2019 Jan 14;9(1):e3. Epub 2019 Jan 14.

Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. Read More

Hemodial Int 2019 Feb 7. Epub 2019 Feb 7.

Department of Kidney Disease, Kawashima Hospital, 1-39 Kitasakoichiban-cho, Tokushima, 770-0011, Japan.

Hemodialysis patients have weakened immune systems and can exhibit fever due to various causes. Herein, we describe the case of a 61-year-old hemodialysis patient who exhibited intermittent low-grade fever after a pacemaker had been implanted 2 months before due to sick sinus syndrome. She had a medical history of subcutaneous sarcoidosis and uveitis. Read More

Euro Surveill 2019 Jan;24(5)

Authors contributed equally to the work and share last authorship.

BackgroundCrimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, ticks.AimsTo review scientific literature and collect experts' opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Read More

J Gastrointest Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Surgery, University of Chicago Medical Center, Transplantation Institute, 5841 S. Maryland Ave. MC5027, Room J-517, Chicago, IL, 60637, USA.

Introduction: We assessed whether positive microbiological cultures from the islet preparation had any effect on the risk of infectious complications (IC) after total pancreatectomy with islet autotransplantation (TPIAT) in our center.

Methods: We analyzed preservation fluid and final islet product surveillance cultures with reference to clinical data of patients undergoing TPIAT. All patients received routine prophylactic broad-spectrum antibiotics. Read More

Glob Pediatr Health 2019 23;6:2333794X18822999. Epub 2019 Jan 23.

Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Fever of unknown origin is an important diagnostic challenge in pediatrics that requires a thoughtful approach. The differential diagnosis is broad and includes infectious, autoimmune, oncologic, neurologic, genetic, and iatrogenic causes. Infection remains the most common etiology, and uncommon presentations of infections are still more likely than classic presentations of rare conditions. Read More

Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, Division of Rheumatology, Hacettepe University Medical School, Sihhiye, 06100, Ankara, Turkey.

Objective: To identify several clinical and/or laboratory parameters which can differentiate adult-onset Still's disease (AOSD) from other causes of fever of unknown origin (FUO) and create a clinician-friendly algorithm for this purpose.

Methods: FUO patients hospitalized between March 2015 and September 2017 were recruited prospectively. AOSD patients diagnosed between 2001 and 2017 in our department were analyzed. Read More

Zhonghua Er Ke Za Zhi 2019 Feb;57(2):118-124

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To explore clinical features and the effect of treatment of neuromyelitis optica spectrum disorders (NMOSD) in childhood. Children who were hospitalized in Department of Pediatrics, Peking University First Hospital from January 2013 to June 2018 and meeting diagnostic criteria of NMOSD proposed by the International Panel for NMOSD Diagnosis in 2015 were summarized and followed up. The basic information, symptoms of each attack, locations and patterns of new lesions, features of cerebrospinal fluid, serologic markers, treatments and outcomes in these patients were analyzed. Read More

Front Neurosci 2018 14;12:1054. Epub 2019 Jan 14.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.

Brain abscess, a severe intracranial infectious disease, refers to the parenchyma abscess caused by local infection or remote spread. Recently, advancements in modern medicine, especially the wide application of antimicrobial drugs, have contributed to the gradual decrease in the prevalence of this disease. However, cases of cryptogenic brain abscess that feature an unknown origin and atypical symptoms are rising. Read More

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):63-65

Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Isolated sphenoid sinusitis is a rare disorder and may present with severe complications due to its proximity to the orbital and intracranial areas. We report a 13-year-old boy hospitalized for septic shock with fever of unknown origin. Facial palsy was later noted. Read More

Expert Rev Anti Infect Ther 2019 Jan 28. Epub 2019 Jan 28.

d Department of Hematology and Oncology , Medical Center, Otto-von-Guericke University , Magdeburg , Germany .

Introduction: Infections are among the most frequent complications in patients with hematological and oncological diseases. They might be classified as fever of unknown origin, and microbiologically or clinically documented infections. Optimal duration of antimicrobial treatment is still unclear in these patients. Read More

J Med Case Rep 2019 Jan 27;13(1):24. Epub 2019 Jan 27.

QEII Health Sciences Centre, Room 409 Bethune Building, 1276 South Park Street, Halifax, NS, B3H 2Y9, Canada.

Background: Fever of unknown origin is often a diagnostic dilemma for clinicians due to its extremely broad differential. One of the rarer categories of disease causing fever of unknown origin is malignancies; of these, soft tissue sarcoma is one of the least common. Soft tissue sarcomas make up < 1% of all adult malignancies and often do not present with any systemic manifestations or neoplastic fevers. Read More

Intern Med J 2019 Jan 22. Epub 2019 Jan 22.

Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.

Background: Preliminary studies have reported promising results for the utility of Ga-68 citrate PET-CT for infection imaging. This technique offers reduced radiation dose to patients, shorter time between injection and imaging and reduced time for image acquisition compared to the 'gold standard' nuclear imaging technique: Ga-67 citrate scintigraphy.

Aims: To compare the two imaging modalities to ascertain whether Ga-68 citrate PET-CT is of equivalent diagnostic efficacy for bone and joint infection or pyrexia of unknown origin (PUO) and to assess image quality and reporter confidence. Read More

Acta Biomed 2019 Jan 15;89(4):585-588. Epub 2019 Jan 15.

Department of Imaging, Bambino Gesù Children's Hospital, Rome, Italy.

Cat-scratch disease (CSD) is usually a self-limiting infection that in the majority of cases occurs as lymphadenitis in children who have been scratched or bitten by a cat. Rarely, Bartonella henselae is cause of fever of unknown origin (FUO), with dissemination to various organs, mimicking an inflammatory rather than a lymphoproliferative disease. This manuscript will present a case of thoracic manifestations of CSD in an immunocompetent 2-years baby without history of cat contact, with fever of unknown origin, investigated by chest CT and MRI. Read More

J Infect Chemother 2019 Jan 11. Epub 2019 Jan 11.

Department of Infectious Diseases, The University of Tokyo; Department of Infection Control and Prevention, The University of Tokyo.

Chronic granulomatous disease (CGD) is a primary immunodeficiency disease characterized by severe recurrent infections such as pneumonia, liver and skin infections. However, prostatic abscesses are rare as only two cases have been reported thus far. We present the case of a 41-year-old patient with CGD who was admitted to the hospital with fever and subsequently, Klebsiella pneumoniae was identified on blood culture. Read More

J Clin Neurosci 2019 Jan 9. Epub 2019 Jan 9.

Department of Radiology, Assistance Publique-Hôpitaux de Paris, Bichat University Hospital, 46 rue Henri Huchard, 75018 Paris, France; INSERM U738, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, France. Electronic address:

Acute subdural hematoma (ASDH) revealing mycotic aneurysm (MA) is an exceptional occurrence. We report 2 cases of MA-related pure ASDH in the course of infective endocarditis (IE) without history of head trauma, hypertension or coagulopathy. Case 1: A 54-year-old man presented with a 10-day history of headache, fever. Read More

Case Rep Infect Dis 2018 2;2018:7956890. Epub 2018 Dec 2.

First Department of Internal Medicine, G. Papanikolaou General Hospital, Thessaloniki, Greece.

has mainly been reported to cause infections in animals. Its clinical significance as a human pathogen has not yet been fully elucidated and needs further investigation. We describe here a case of bacteremia attributed to in a 55-year-old female patient admitted to our department due to fever of unknown origin. Read More

Med Mycol Case Rep 2019 Mar 21;23:53-54. Epub 2018 Dec 21.

Division of Infectious Disease, Department of Internal Medicine, St. John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Detroit 48236, MI, United States of America.

Hematopoietic and solid organ transplant recipients are at increased risk of opportunistic infections and infections usually are severe due to impaired cell mediated immunity. We report an unusual case of disseminated histoplasmosis in a renal transplant recipient manifesting with a chronic progressive course over several years. After starting treatment with itraconazole, the patient showed marked improvement in his symptoms and had clinical resolution. Read More

Cochrane Database Syst Rev 2019 Jan 3;1:CD012184. Epub 2019 Jan 3.

Division of Infectious Diseases, Rambam Health Care Campus, Ha-aliya 8 St, Haifa, Israel, 33705.

Background: People with cancer with febrile neutropenia are at risk of severe infections and mortality and are thus treated empirically with broad-spectrum antibiotic therapy. However, the recommended duration of antibiotic therapy differs across guidelines.

Objectives: To assess the safety of protocol-guided discontinuation of antibiotics regardless of neutrophil count, compared to continuation of antibiotics until neutropenia resolution in people with cancer with fever and neutropenia, in terms of mortality and morbidity. Read More

Trop Doct 2018 Dec 28:49475518819622. Epub 2018 Dec 28.

1 Registrar, Department of Infectious Diseases, Apollo Hospitals, Hyderabad, Telangana, India.

We present an unusual case of fever of unknown origin with bilateral adrenal masses in a patient with compensated chronic liver disease (compensated) due to hepatitis C who had been treated elsewhere with four months of anti-tuberculous therapy for suspected disseminated tuberculosis (TB). At our institution, he underwent a CT-guided biopsy of the adrenal lesion which to our surprise did not reveal any evidence of TB but a close mimic. Read More

Indian Pediatr 2018 Nov;55(11):997-998

Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research and Dr Ram Manohar Lohia Hospital, New Delhi, India.

Background: Urinoma is an encapsulated collection of extravasated urine, secondary to trauma or obstructive uropathy. Spontaneous bilateral urinoma is rare.

Case Characteristics: 7-year-old boy with cyanotic heart disease and fever of unknown origin. Read More

J Adv Res 2019 Jan 18;15:111-116. Epub 2018 Jul 18.

Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon and life-threatening disorder that may rarely complicate the clinical course of Orientia tsutsugamushi disease (scrub typhus). Here, we describe the clinical features, laboratory parameters, management, and outcome of 16 children with scrub typhus-associated HLH. All patients satisfied the HLH-2004 diagnostic criteria. Read More

Mediators Inflamm 2018 26;2018:4869329. Epub 2018 Nov 26.

Pediatrics, Università degli Studi di Milano, Milan, Italy.

Introduction: Among neonates and infants <3 months of age with fever without a source (FWS), 5% to 15% of cases are patients with fever caused by a serious bacterial infection (SBI). To favour the differentiation between low- and high-risk infants, several algorithms based on analytical and clinical parameters have been developed. The aim of this review is to describe the management of young infants with FWS and to discuss the impact of recent knowledge regarding FWS management on clinical practice. Read More

Rev Esp Quimioter 2019 Feb 20;32(1):91-92. Epub 2018 Dec 20.

Jordi Reina, Unidad de Virología, Hospital Universitario Son Espases Carretera Valldemossa s/n, 07010 Palma de Mallorca. Spain.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

A 58-year-old immunocompetent woman presented with fever and significant weight loss of 4-month duration. She had mild pallor; rest of the examination was unremarkable. Investigations revealed anaemia with raised inflammatory markers. Read More

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Paediatrics, Kasturba Medical College, Manipal, Karnataka, India.

Scrub typhus caused by is an important cause for fever of unknown origin in endemic areas including India. The vasculitis associated with the disease leads to a variety of clinical manifestations. However, the joint involvement is quite rare and not reported in children. Read More

Clin Nucl Med 2019 Mar;44(3):251-254

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Focal myositis is an uncommon inflammatory pseudotumor of the skeletal muscle that may mimic neoplastic and inflammatory diseases. We present one case of focal myositis involving the left proximal vastus lateralis and vastus intermedius, and left soleus showing intense FDG uptake on FDG PET/CT. This case indicates that focal myositis should be considered as a differential diagnosis in patients with focal hypermetabolic muscular lesions, including benign and malignant tumors, necrotizing autoimmune myopathy, nodular fasciitis, myositis ossificans, and muscular sarcoidosis. Read More

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Zentralinstitut für Seelische Gesundheit, AG Schizophrenieforschung; Medizinische Fakultät Mannheim / Universität Heidelberg.

The concept of mental disorder has many facets. Specific concepts of disease or disorder stand for individual entities, classified as diagnoses. Ideally, they are based on discrete physical, neurobiological or - as is the case with hereditary diseases - genetic findings. Read More

Arch Pediatr 2019 Jan 13;26(1):16-20. Epub 2018 Dec 13.

UMR_A 1341, UMR_S 1241, Inra, Inserm, institut NUMECAN, université de Rennes, 2 rue Henri-le-Guilloux, 35000 Rennes, France; Service de chirurgie pédiatrique, université de Rennes, CHU de Rennes, hôpital Sud16, boulevard de Bulgarie, , 35203 Rennes cedex 2, France.

Introduction: Since April 2015, the French Society of Pediatrics has encouraged suprapubic aspiration (SA) and urethral catheterization (UC) for urine collection in non-toilet-trained children suspected of having urinary tract infections (UTIs) and has tried to reduce the use of urine bag (UB).

Objective: To analyze the medical practices concerning urine collection methods used for non-toilet-trained children in pediatric emergency departments in France.

Methods: We conducted a descriptive medical practice study in October 2017. Read More

Clin Ter 2018 Nov-Dec;169(6):e274-e276

Department of Infectious Diseases, Military Medical Academy, Sofia, Bulgaria.

We present a case of 68-year-old female with four months history of fever, fatigue, and weight loss. She was classified as case of fever of unknown origin. The physical examination was normal, the laboratory tests showed anemia, elevation of C-reactive protein, erythrocyte sedimentation rate and fibrinogen. Read More

PLoS One 2018 13;13(12):e0208622. Epub 2018 Dec 13.

Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama, United States of America.

Objectives: Lumbar puncture (LP) is an important technique for assessing and treating neurological symptoms. The objective of this study was to describe the characteristics of diagnostic lumbar punctures performed on hospitalized patients in the United States.

Methods: We analyzed data from the 2010 National Inpatient Sample (NIS) and the National Emergency Department Survey (NEDS). Read More

Curr Med Sci 2018 Dec 7;38(6):1025-1031. Epub 2018 Dec 7.

Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

The present study aimed to establish a list of parameters indicative of pathogen invasion and develop a predictive model to distinguish the etiologies of fever of unknown origin (FUO) into infectious and non-infectious causes. From January 2014 to September 2017, 431 patients with FUO were prospectively enrolled in the study population. This study established a list of 26 variables from the following 4 aspects: host factors, epidemiological factors, behavioral factors, and iatrogenic factors. Read More

Int J Infect Dis 2019 Jan 25;78:121-127. Epub 2018 Oct 25.

Bundeswehr Institute of Microbiology, Department Virology and Intracellular Agents, German Centre for Infection Research, Munich Partner Site, Munich, Germany. Electronic address:

Objectives: The aim of this study was to detect the seroprevalence of Crimean-Congo haemorrhagic fever virus (CCHFV) in patients with fever of unknown origin (FUO) in endemic (Kyzylorda) and non-endemic (Almaty) oblasts of Kazakhstan.

Methods: Paired serum samples from 802 patients with FUO were collected. Serum samples were investigated by ELISA to detect IgG and IgM antibodies against CCHFV. Read More

Saudi Med J 2018 Dec;39(12):1195-1199

Department of Pathology, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To evaluate the presence of Coxiella burnetii  (C. brunetii) infection among patients presenting with fever of unknown origin (FUO).

Methods: A cross-sectional study of 100 patients (54 men and 46 women; mean age: 34. Read More

Top Companion Anim Med 2018 Dec 29;33(4):97-99. Epub 2018 Aug 29.

Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

An 18-month-old domestic short hair male castrated cat presented with a history of fever of unknown origin of 1-year duration. Abdominal ultrasound revealed a mixed echogenicity mass. Cytological examination of the fluid obtained through fine needle aspiration was consistent with a retroperitoneal abscess. Read More

Einstein (Sao Paulo) 2018 Nov 29;16(4):eRC4505. Epub 2018 Nov 29.

Serviço de Pediatria Médica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Idiopathic pulmonary hemosiderosis is a potentially fatal disease that results from episodes of alveolar hemorrhage of unknown origin. The clinical spectrum is varied, and anemia may constitute the only manifestation of illness, preceding other signs and symptoms by several months. We present the case of a 4 year-old child presenting with fever, vomiting and prostration, associated with pallor. Read More

Infection 2018 Nov 29. Epub 2018 Nov 29.

Department of Infectious Diseases and Clinical Microbiology, Ege University Faculty of Medicine, Izmir, Turkey.

Purpose: In this multicentre, retrospective, matched cohort study we aimed to evaluate the outcomes of neutropenic fever cases that were treated with daptomycin or a glycopeptide (vancomycin or teicoplanin).

Methods: Data and outcomes of adult (aged > 18-years old) patients with neutropenic fever [(1) without clinical and radiological evidence of pneumonia, (2) who were treated with daptomycin or a glycopeptide (teicoplanin or vancomycin) for any reason and for at least 72 h] were extracted from the hospital databases. Matching was performed with all of the three following criteria: (1) underlying disease, (2) reason for starting daptomycin or glycopeptide (microbiologic evidence vs. Read More

Case Rep Endocrinol 2018 25;2018:5041724. Epub 2018 Oct 25.

Monmouth Medical Center, Long Branch, NJ 07740, USA.

An 80-year-old Caucasian male presented with fever of 3-week duration. Outpatient workup for infectious etiologies was negative and due to persistent fever, he was hospitalized for further evaluation of fever of unknown origin (FUO). Physical examination and laboratory studies remained unremarkable; however a follow-up CT scan of chest, abdomen, and pelvis with contrast done to rule out malignancy as an underlying cause of FUO revealed heterogeneous thyroid gland with surrounding hazy changes suggestive of thyroiditis. Read More

Rev Esp Med Nucl Imagen Mol 2018 Nov - Dec;37(6):354-358. Epub 2018 Jun 28.

Servicio de Enfermedades Infecciosas, Complejo Hospitalario Universitario de Badajoz, Badajoz, España.

Introduction And Objective: Febrile syndromes of unknown origin (FSUO) are complex processes in hospital practice. Their management includes an exhaustive medical history and examination, as well as an extensive number of biochemical tests. If these are inconclusive, diagnostic imaging techniques such as SPECT/CT with -Gallium Citrate (Ga-SPECT/CT) could play an important role. Read More

Pediatr Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Pediatric Rheumatology Division, Pediatrics Department, Universidade Federal de São Paulo, São Paulo, Brazil.

Pediatr Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Pediatric Rheumatology Division, Pediatrics Department, Universidade Federal de São Paulo, São Paulo, Brazil.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of General Internal Medicine, Hiroshima University Hospital, Japan.

A 78-year-old woman with fever of unknown origin that had persisted for 3 months, systemic edema, and cervical lymphadenopathy was admitted to our hospital. Skin purpura and jaw claudication were subsequently observed. Histopathological examinations of the lymph nodes, skin, and temporal artery revealed findings characteristic of eosinophilic granulomatosis with polyangiitis (EGPA). Read More