6,388 results match your criteria Fever of Unknown Origin


Clinical activity at the UK military level 2 hospital in Bentiu, South Sudan during Op TRENTON from June to September 2017.

J R Army Med Corps 2019 Apr 20. Epub 2019 Apr 20.

Academic Department of Military Medicine, Royal Centre for Defence Medicine, Birmingham, UK.

Introduction: Diseases and non-battle injuries (DNBIs) are common on UK military deployments, but the collection and analysis of clinically useful data on these remain a challenge. Standard medical returns do not provide adequate clinical information, and clinician-led approaches have been laudable, but not integrated nor standardised nor used long-term. Op TRENTON is a novel UK military humanitarian operation in support of the United Nations Mission in South Sudan, which included the deployment of UK military level 1 and level 2 medical treatment facilities at Bentiu to provide healthcare for UK and United Nations (UN) personnel. Read More

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http://dx.doi.org/10.1136/jramc-2018-001154DOI Listing

Influenza A (H1N1) pdm09 virus infection in a patient with incomplete Kawasaki disease: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15009

Department Second of Infectious Diseases.

Rationale: Kawasaki disease (KD) is a vasculitic illness of childhood associated with coronary artery dilatation, coronary artery aneurysm, arrhythmia, sudden death, and other serious cardiovascular diseases. Up to date, the etiology of KD remains unclear; however, epidemiological characteristics indicate that it may be related to as-yet-undefined pathogen infection.

Patient Concerns: A 19-month-old boy had a fever of unknown origin at 38°C for 9 days without rash, runny nose and cough. Read More

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http://dx.doi.org/10.1097/MD.0000000000015009DOI Listing
April 2019
2 Reads

Evaluation of loop-mediated isothermal amplification assay for detection of scrub typhus in patients with acute febrile illness presenting to a Tertiary Care Center in Puducherry, India.

J Lab Physicians 2019 Jan-Mar;11(1):82-86

Department of Microbiology, Pondicherry Institute of Medical Sciences, Puducherry, India.

Purpose: Scrub typhus an acute febrile illness has diverse clinical manifestations, which overlap with other febrile illnesses. Due to this reason, it is misdiagnosed, leading to inappropriate treatment, sometimes resulting in fatality. Thus, accurate diagnosis of scrub typhus is important for appropriate treatment. Read More

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http://dx.doi.org/10.4103/JLP.JLP_148_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437831PMC
April 2019
1 Read

Cervical syphilitic lymphadenitis causing fever of unknown origin followed by rash of secondary syphilis.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):339-340

Division of Infectious Diseases, Northport Veterans Affairs Medical Center, Northport, NY 11768, USA.

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http://dx.doi.org/10.4103/IJPM.IJPM_188_18DOI Listing
April 2019
1 Read

Acute rheumatic fever associated with tenosynovitis and a unique cytokine profile.

Immunol Med 2018 Mar 3;41(1):43-45. Epub 2018 Apr 3.

a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.

Acute rheumatic fever (ARF), caused by group A β-hemolytic streptococcus infection, is characterized by inflammation affecting several organs. There are few reports on magnetic resonance imaging (MRI) findings in patients with ARF. An 8-year-old Japanese boy presented with a prolonged fever of unknown cause and swelling of his right hand. Read More

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http://dx.doi.org/10.1080/09114300.2018.1451617DOI Listing
March 2018
10 Reads

Etiology of Classic Fever of Unknown Origin (FUO) among Immunocompetent Indian Adults.

J Assoc Physicians India 2019 Jan;67(1):21-26

Professor, Department of Geriatrics, Department of Biostatistics, Christian Medical College and Hospital, Vellore, Tamil Nadu.

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January 2019
2 Reads

A Case of Pancytopenia with Many Possible Causes: How Do You Tell Which is the Right One?

Eur J Case Rep Intern Med 2019 30;6(2):001012. Epub 2019 Jan 30.

Department of Internal Medicine, Cascais Hospital, Cascais, Portugal.

Systemic lupus erythematosus (SLE) often presents with cytopenia(s); however, pancytopenia is found less commonly, requiring the consideration of possible aetiologies other than the primary disease. The authors describe the case of a female patient with a recent diagnosis of SLE admitted through the Emergency Department with fever of unknown origin and severe pancytopenia. She was medicated with prednisolone, hydroxychloroquine, azathioprine, amlodipine and sildenafil. Read More

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http://dx.doi.org/10.12890/2019_001012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432823PMC
January 2019
1 Read

The impact of temporal artery biopsy for the diagnosis of giant cell arteritis in clinical practice in a tertiary university hospital.

PLoS One 2019 29;14(3):e0210845. Epub 2019 Mar 29.

Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Background: Temporal artery biopsy (TAB) is useful in assisting with giant cell arteritis (GCA) diagnosis but lacks sensitivity. The aim of our study was to assess the diagnostic impact of TAB histology in patients with suspected GCA on hospital admission.

Methods: A prospectively maintained database was queried for all TABs performed between 1-1-2000 until 31-12-2017 at the University Hospital of Ioannina. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210845PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440612PMC
March 2019
2 Reads
3.234 Impact Factor

Clinical Characteristics of Saffold Virus Infection in Children.

Pediatr Infect Dis J 2019 Mar 21. Epub 2019 Mar 21.

Department of Pediatrics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Background: Saffold virus (SAFV) is a novel human cardiovirus that was identified in 2007. Recently, SAFV has been isolated from nasal and stool specimens of infants presenting with respiratory and gastrointestinal symptoms and from cerebrospinal fluid (CSF) specimens of children with central nervous system infection. However, little is known regarding clinical characteristics of SAFV in children. Read More

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http://dx.doi.org/10.1097/INF.0000000000002298DOI Listing
March 2019
12 Reads

[One case of refractory gout with high fever].

Zhonghua Shao Shang Za Zhi 2019 Mar;35(3):224-227

Skin Wound Repair Center of Department of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan 430070, China.

On 17th June 2017, a 50 years old man with refractory gout was admitted in our hospital. During the treatment, he was accompanied by intermittent fever (39 to 40 ℃) of unknown origin for 60 days and gastrointestinal bleeding, with difficult wound repair. After comprehensive treatment of thorough debridement, vacuum sealing drainage, skin graft, skin flap repair, and drug administration, the patient was discharged fully recovered on post hospitalization day 104. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.03.012DOI Listing
March 2019
1 Read

Fever of unknown origin: a retrospective review of pediatric patients from an urban, tertiary care center in Washington, DC.

World J Pediatr 2019 Mar 19. Epub 2019 Mar 19.

Division of Pediatric Rheumatology, Children's National Health System, Washington, DC, USA.

Background: Fever of unknown origin (FUO) continues to challenge clinicians to determine an etiology and the need for treatment. This study explored the most common etiologies, characteristics, and average cost of hospitalization for FUO in a pediatric population at an urban, tertiary care hospital in Washington, DC.

Methods: Records from patients admitted to Children's National Health System between September 2008 and April 2014 with an admission ICD-9 code for fever (780. Read More

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http://dx.doi.org/10.1007/s12519-019-00237-3DOI Listing
March 2019
1 Read

Management of acute mitochondriopathy and encephalopathy syndrome in pediatric intensive care unite: a new clinical entity.

Acta Neurol Belg 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Acute mitochondriopathy and encephalopathy syndrome (AMES) is described differently by different authors in the literature. As a new clinical entity, we aimed to present the clinical signs and symptoms, diagnosis and treatment algorithm of our patients with AMES. 56 patients aged between 2 months and 18 years who were followed up in pediatric intensive care units of Konya Training and Research Hospital and Selcuk University Medical Faculty Hospital, between January 2010 and June 2017 were included. Read More

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http://dx.doi.org/10.1007/s13760-019-01125-3DOI Listing
March 2019
1 Read

Four-extremity venous duplex ultrasound for suspected deep venous thrombosis is an anachronism.

J Vasc Surg Venous Lymphat Disord 2019 May 15;7(3):325-332.e1. Epub 2019 Mar 15.

Division of Vascular Disease and Surgery, Department of Surgery, The Ohio State University, Columbus, Ohio. Electronic address:

Background: Duplex ultrasound is the "gold standard" for diagnosis of acute deep venous thrombosis (DVT) because of its high specificity, sensitivity, safety, and portability. However, unnecessary testing epitomizes inefficient use of scarce health care resources. Here we hypothesize that the majority of simultaneous four-extremity duplex ultrasound (FED) examinations are unnecessary. Read More

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http://dx.doi.org/10.1016/j.jvsv.2018.11.004DOI Listing
May 2019
1 Read

Monoclonal gammopathy, arthralgias, and recurrent fever syndrome: a new autoinflammatory syndrome?

J Rheumatol 2019 03 15. Epub 2019 Mar 15.

Hôpital Tenon (AP-HP) - Service de Médecine Interne, Paris, France

Objective: The objective of this work was to describe a new autoinflammatory syndrome with recurrent fever and monoclonal gammopathy that differs from Schnitzler syndrome.

Methods: We conducted a retrospective study of patients with monoclonal gammopathy and recurrent fever of unknown origin.

Results: Five patients were included in the description. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.181204
Publisher Site
http://dx.doi.org/10.3899/jrheum.181204DOI Listing
March 2019
3 Reads

A novel diagnostic algorithm equipped on an automated hematology analyzer to differentiate between common causes of febrile illness in Southeast Asia.

PLoS Negl Trop Dis 2019 03 14;13(3):e0007183. Epub 2019 Mar 14.

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands.

Background: Distinguishing arboviral infections from bacterial causes of febrile illness is of great importance for clinical management. The Infection Manager System (IMS) is a novel diagnostic algorithm equipped on a Sysmex hematology analyzer that evaluates the host response using novel techniques that quantify cellular activation and cell membrane composition. The aim of this study was to train and validate the IMS to differentiate between arboviral and common bacterial infections in Southeast Asia and compare its performance against C-reactive protein (CRP) and procalcitonin (PCT). Read More

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http://dx.doi.org/10.1371/journal.pntd.0007183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435198PMC
March 2019
5 Reads

The changing pattern of fever of unknown origin in Republic of North Macedonia.

Rom J Intern Med 2019 Mar 11. Epub 2019 Mar 11.

University Hospital for Infectious diseases and febrile conditions, Medical Faculty "Ss Cyril and Methodius" University, Skopje, Republic of North Macedonia.

Introduction: The study aimed to compare the etiologic spectrum of diseases causing fever of unknown origin (FUO) and methods for definitive diagnosis in a tertiary care hospital in Republic of North Macedonia during two different time periods.

Patients And Methods: retrospectively were analysed the causes for FUO and final diagnostic approaches in 185 patients with classic FUO that were treated at the University Hospital for Infectious diseases in Skopje during two time periods. Seventy nine patients were treated during 1991 to 1995 and 106 patients during 2011 to 2015. Read More

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http://dx.doi.org/10.2478/rjim-2019-0007DOI Listing
March 2019
2 Reads

Comparison of the Power of Procalcitonin and C-Reactive Protein to Discriminate between Different Aetiologies of Fever in Prolonged Profound Neutropenia: A Single-Centre Prospective Observational Study.

Mediterr J Hematol Infect Dis 2019 1;11(1):e2019023. Epub 2019 Mar 1.

Department of Haematology, Antwerp University Hospital, Edegem, Belgium.

Management of fever in prolonged, profound neutropenia remains challenging with many possible infectious and non-infectious causes. We investigated whether procalcitonin (PCT) is superior to C-reactive protein (CRP) in discriminating between different aetiologies of fever in this setting. CRP and PCT were tested daily during 93 neutropenic episodes in 66 patients. Read More

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http://dx.doi.org/10.4084/MJHID.2019.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402549PMC
March 2019
1 Read

Fever of unknown origin and Q-fever: a case series in a Bulgarian hospital.

Caspian J Intern Med 2019 ;10(1):102-106

Department of Infectious Diseases, Military Medical Academy, Sofia, Bulgaria.

Background: Fever of unknown origin (FUO) is a perplexing medical problem. The causes for FUO are more than 200 diseases. The aim of the study was to present human clinical cases of infection debuting as FUO. Read More

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http://dx.doi.org/10.22088/cjim.10.1.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386320PMC
January 2019
3 Reads

An investigation of pyrexia of unknown origin in Shamva District, Zimbabwe, September 2015.

Pan Afr Med J 2018 18;30(Suppl 1):10. Epub 2018 May 18.

African Field Epidemiology Network, Accra, Ghana.

Outbreak investigation is a key component of public health training. A good outbreak investigation can go beyond determining the causative agent by recommending policies to be formulated by policy makers. This case study simulates a real-life investigation of pyrexia of unknown origin in Shamva District, Zimbabwe, during the period of September to October 2015. Read More

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http://dx.doi.org/10.11604/pamj.supp.2018.30.1.15270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379557PMC

Diagnostic utility of F-FDG PET/CT in fever of unknown origin among patients with end-stage renal disease treated with renal replacement therapy.

Hell J Nucl Med 2019 Jan-Apr;22(1):70-75. Epub 2019 Mar 7.

Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria 0001, South Africa.

Objective: To evaluate the role of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in identifying the cause of fever of unknown origin (FUO) in patients on renal replacement therapy (RRT) for end-stage renal disease (ESRD).

Subjects And Methods: We retrospectively reviewed the F-FDG PET/CT scans of 46 patients with a mean age of 39.28±12. Read More

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http://dx.doi.org/10.1967/s002449910962DOI Listing
March 2019
0.925 Impact Factor

Unusual Manifestation of Ulcerative Colitis.

Case Rep Pediatr 2019 31;2019:5163213. Epub 2019 Jan 31.

Pediatric Gastroenterology Division, Children's Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.

The relationship of inflammatory bowel disease (IBD) and chronic recurrent multifocal osteomyelitis (CRMO) is understood as extraintestinal rheumatic manifestations. CRMO is a chronic, relapsing, inflammatory, noninfectious disorder of the skeletal system of unknown origin. The disease course is not always recurrent. Read More

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http://dx.doi.org/10.1155/2019/5163213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374790PMC
January 2019
5 Reads

[Application of multiplex PCR assay to study early multiple herpesviruses infection during HSCT].

Zhonghua Xue Ye Xue Za Zhi 2019 Feb;40(2):125-131

The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Institute of Blood and Marrow Transplantation, Suzhou 215006, China.

To investigate herpesvirus infection in early stage of hematopoietic stem cell transplantation (HSCT) by multiplex polymerase chain reaction (PCR), and to explore the association between multiple herpesviruses infection and clinical characteristics in HSCT patients and its impact on post-transplant complications and prognosis. A total of 734 peripheral blood samples were collected from 90 patients undergoing HSCT in the Department of Hematology, the First Affiliated Hospital of Soochow University between February 2017 and August 2017. The peripheral blood specimens were obtained before and within 90 days after transplantation at different time points. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.02.006DOI Listing
February 2019
1 Read

Discontinuation of antimicrobial therapy in adult neutropenic haematology patients: A prospective cohort.

Int J Antimicrob Agents 2019 Mar 2. Epub 2019 Mar 2.

Service de réanimation et maladies infectieuses, CH Tourcoing, 59208 Tourcoing, France.

Objectives: Antibiotics for febrile neutropenia (FN) in acute myeloid leukaemia (AML) patients undergoing intensive chemotherapy are usually maintained until neutropenia resolution, because of the risk of uncontrolled sepsis in this vulnerable population. This leads to unnecessarily prolonged antimicrobial therapy.

Methods: Based on ECIL-4 recommendations, we modified our management strategy and discontinued antibiotics after a pre-established duration in patients treated for a first episode of FN between August 2014 and October 2017. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.020DOI Listing
March 2019
3 Reads

Disseminated Infection Visualized by [F]FDG-PET/CT and MRI.

Diagnostics (Basel) 2019 Mar 1;9(1). Epub 2019 Mar 1.

Department of Internal Medicine, Zealand University Hospital, 4000 Roskilde, Denmark.

We describe the clinical course of a 24-year old male with Crohn's disease in immunosuppressive therapy admitted with a 6-week history of fever, weight loss, night sweat, and general malaise. The patient received extensive workup for a fever of unknown origin and received empiric antibiotics. Workup with Fluorine-18 fluoro-2-deoxy-d-glucose ([F]FDG) positron-emission tomography (PET/CT), and magnetic resonance imaging (MRI) with intravenous contrast showed multifocal ostitis of the columna and os sacrum, as well as abscesses in m. Read More

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http://dx.doi.org/10.3390/diagnostics9010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468605PMC

Clinical features and outcomes of patients with fever of unknown origin: a retrospective study.

BMC Infect Dis 2019 Feb 27;19(1):198. Epub 2019 Feb 27.

Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1st Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Few studies have reported the long-term clinical outcome of patients discharged with undiagnosed fever of unknown origin (FUO). In this study, the clinical features and outcomes of patients with unexplained fever were explored to improve our understanding of FUO.

Method: Patients diagnosed with FUO at admission and discharged without final diagnoses after systematic examination in the department of infectious diseases at Peking Union Medical College Hospital between 2004 and 2010 were followed up by telephone. Read More

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http://dx.doi.org/10.1186/s12879-019-3834-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391771PMC
February 2019
6 Reads

Shunt Infection as a Rare Presentation of Neurobrucellosis.

Case Rep Infect Dis 2019 21;2019:7291482. Epub 2019 Jan 21.

Infectious Diseases Specialist, Full Professor, Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Brucellosis, as a systemic infection with potential to involving virtually all organ systems, is an endemic zoonosis in Iran. This is the history of a 17-year-old boy with a ventriculoperitoneal (VP) shunt who presented with prolonged fever, constipation, and abdominal pain. Laboratory studies, including cerebrospinal fluid (CSF) and blood tests, revealed a VP shunt infection with spp. Read More

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http://dx.doi.org/10.1155/2019/7291482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360539PMC
January 2019
1 Read

Heterotopic ossification with fever of unknown origin.

CMAJ 2019 Feb;191(8):E232

Department of Cardiovascular Medicine (Godo), Tohoku University Graduate School of Medicine; Department of Emergency and Critical Care Medicine (Godo, Kushimoto), Tohoku University Hospital; Division of Emergency and Critical Care Medicine (Kushimoto), Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1503/cmaj.180617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389456PMC
February 2019
1 Read

Suspected phenobarbital-induced fever in a cat.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919830214. Epub 2019 Feb 18.

VCA Animal Specialty Center of South Carolina, Columbia, SC, USA.

Case Summary: A 3-year-old spayed female domestic shorthair cat developed a fever 1 week after starting the anticonvulsant phenobarbital. A diagnostic work-up for seizures and subsequent onset of fever of unknown origin, consisting of MRI of the brain, cerebrospinal fluid analysis and infectious disease testing, was unremarkable. The cat was switched from phenobarbital onto pregabalin with complete resolution of the fever within 24 h, consistent with a drug-induced fever following phenobarbital administration. Read More

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http://dx.doi.org/10.1177/2055116919830214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379798PMC
February 2019
3 Reads

Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions.

Yonsei Med J 2019 Mar;60(3):312-314

Department of Pediatrics, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan.

We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-old girl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.3.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391528PMC
March 2019
1 Read

Correction to: Proposal for a simple algorithm to differentiate adult-onset Still's disease with other fever of unknown origin causes: a longitudinal prospective study.

Clin Rheumatol 2019 Apr;38(4):1193-1194

Department of Internal Medicine, Division of Rheumatology, Hacettepe University Medical School, Sihhiye, 06100, Ankara, Turkey.

The author regrets that the original version of this article contained error. Figure 1 was shown in the wrong version, thus corrected figure is shown in this article. Read More

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http://dx.doi.org/10.1007/s10067-019-04479-4DOI Listing
April 2019
2 Reads

Combined Laboratory Approach to Detection of Parvovirus B19 and Coxiella Burnetii in Patients with Fever of Unknown Origin.

Clin Lab 2019 Jan;65(1)

Background: Fever of unknown origin (FUO) is one of the greatest challenges for clinicians and patients. There are more than 200 etiological agents of FUO, among these the most common is the role of infection, neoplasms, and diseases of connective tissue. The aim of the present study is to investigate the role of the infectious agents parvovirus B19 (B19V) and Coxiella burnetii (C. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180617DOI Listing
January 2019
1 Read

Multidrug-resistant Nontyphoidal Salmonella Hotspots as Targets for Vaccine Use in Management of Infections in Endemic Settings.

Clin Infect Dis 2019 Feb;68(Supplement_1):S10-S15

Department of Medicine, University of Cambridge, United Kingdom.

Background: Salmonella infections cause a disproportionately high number of deaths in Africa, especially among poor urban populations. The increasing level of multidrug-resistant (MDR) infections is a major cause of concern in these settings where alternative effective treatment is unavailable. Other options for management of these infections must be sought. Read More

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http://dx.doi.org/10.1093/cid/ciy898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376148PMC
February 2019
3 Reads

Inflammatory Activity of Tumoral Calcinosis in a Patient With Fever of Unknown Origin.

Clin Nucl Med 2019 Apr;44(4):e289-e290

From the Clinics of Nuclear Medicine, and.

Unexpected inflammatory activity of tumoral calcinosis periarticular to the shoulders and hips in a man with recurrent fever of unknown origin and dialysis-dependent kidney insufficiency was revealed by FDG PET/CT. In absence of other pathologies, the calcinosis was deemed to be the cause of the fever. An infectious or malignant disease could be ruled out, so further therapeutic steps were enabled. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002497DOI Listing
April 2019
1 Read

[Disseminated tuberculosis during induction chemotherapy in acute myeloid leukemia].

Internist (Berl) 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Infektiologie und Spitalhygiene, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz.

A patient with acute myeloid leukemia developed disseminated tuberculosis with cerebral involvement in the early phase of induction chemotherapy before allogenic stem cell transplantation. He presented with persisting fever of unknown origin, and initially misinterpreted organ lesions in CT scans. Read More

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http://dx.doi.org/10.1007/s00108-019-0565-zDOI Listing
February 2019
1 Read

Infective endocarditis in two patients with pemphigus vulgaris under multiagent immunosuppressive drug therapy: A rare entity to remember in the differential diagnosis of fever of unknown origin.

Dermatol Ther 2019 Feb 13:e12860. Epub 2019 Feb 13.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Pemphigus vulgaris (PV) is an autoimmune blistering skin disease that may require multiagent immunosuppressive drug therapies in severe cases. In addition to the well-established corticosteroid sparing agents azathioprine, mycophenolate mofetil, and methotrexate, rituximab is being increasingly used alone or in combination in the management of PV. Due to the chronic course of the disease, the cumulative effects of these therapy agents over long follow-up periods may result in various adverse reactions, including bacterial and viral infections. Read More

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http://dx.doi.org/10.1111/dth.12860DOI Listing
February 2019
2 Reads

Skin Rash and Fever of Unknown Origin A Diagnostic Challenge.

Eur J Case Rep Intern Med 2019 10;6(1):001023. Epub 2019 Jan 10.

Department of Medicine, Hospital Pedro Hispano, Unidade Local de Saúde Matosinhos, Matosinhos, Portugal.

We report a clinical case of adult-onset Still's disease. In addition to the imaging features of the case, the following aspects are also briefly described: clinical presentation (prolonged fever associated with migratory polyarthritis and skin rash), treatment performed (resort to anti-inflammatory and corticoid), and clinical evolution of the patient after having performed the adult-onset. The treatment was found to be appropriate as the patient presented a favourable clinical evolution. Read More

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http://dx.doi.org/10.12890/2019_001023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372044PMC
January 2019
1 Read

IgG4-Related Aortitis.

Eur J Case Rep Intern Med 2018 27;5(9):000881. Epub 2018 Sep 27.

Department of Internal Medicine, Centro Hospitalar Conde São Januário, Macau SAR.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory condition characterized by tumefactive lesions that can affect multiple organs. Serum IgG4 levels may be elevated. Early recognition is sometimes difficult but is important to avoid irreversible organ damage. Read More

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http://dx.doi.org/10.12890/2018_000881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346820PMC
September 2018
1 Read

Fever of Unknown Origin: Don't Forget Kala-Azar Even in Europe.

Eur J Case Rep Intern Med 2018 22;5(2):000772. Epub 2018 Feb 22.

Haematology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.

We present the case of a 70-year-old male patient with fever of unknown origin after a long period of convalescence from a previous admission to a chronic care hospital. During the admission, multiple combinations of antibiotic and antifungal treatments were prescribed, but with persistent fever and, eventually, neutropenia (200 lymphocytes, 0 neutrophils). Given the suspicion of infection at bone marrow level, a biopsy was performed as was serology of , both diagnostic determinations. Read More

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http://dx.doi.org/10.12890/2017_000772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346938PMC
February 2018
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A case of anhidrotic ectodermal dysplasia presenting with pyrexia, atopic eczema, and food allergy.

Asia Pac Allergy 2019 Jan 14;9(1):e3. Epub 2019 Jan 14.

Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365661PMC
January 2019
4 Reads

Granulomatous hepatitis by Nocardia species: An unusual case.

Int J Infect Dis 2019 Apr 4;81:97-99. Epub 2019 Feb 4.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

A case of granulomatous hepatitis due to Nocardia is reported here. The case patient was a 63-year-old immunocompetent man who presented with persistent fever, weight loss, and malaise. Radiology suggested an enlarged liver with dense diffuse to multiple tiny micronodular areas of parenchymal involvement, possibly granulomatous. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.046DOI Listing
April 2019
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Clinical evaluation of postoperative fever in patients that had oral and maxillofacial surgery in university of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.

Niger J Clin Pract 2019 Feb;22(2):181-185

Department of Oral and Maxillofacial Surgery, University of Port Harcourt, Port Harcourt, River State, Nigeria.

Background: Postoperative fever (POF) is often encountered after major oral and maxillofacial surgical procedures. This could become an unwanted complication, requiring detailed clinical evaluation and investigations to determine the cause.

Aim: The aim is to determine the major causes of POF in patients that had oral and maxillofacial surgery under general anesthesia at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu. Read More

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http://dx.doi.org/10.4103/njcp.njcp_467_18DOI Listing
February 2019

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review.

Hemodial Int 2019 Apr 7;23(2):E53-E58. Epub 2019 Feb 7.

Department of Kidney Disease, Kawashima Hospital, 1-39 Kitasakoichiban-cho, Tokushima, 770-0011, Japan.

Hemodialysis patients have weakened immune systems and can exhibit fever due to various causes. Herein, we describe the case of a 61-year-old hemodialysis patient who exhibited intermittent low-grade fever after a pacemaker had been implanted 2 months before due to sick sinus syndrome. She had a medical history of subcutaneous sarcoidosis and uveitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hdi.12695
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http://dx.doi.org/10.1111/hdi.12695DOI Listing
April 2019
11 Reads

Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks.

Euro Surveill 2019 Jan;24(5)

Authors contributed equally to the work and share last authorship.

BackgroundCrimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, ticks.AimsTo review scientific literature and collect experts' opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386216PMC
January 2019
6 Reads

Early Infectious Complications After Total Pancreatectomy with Islet Autotransplantation: a Single Center Experience.

J Gastrointest Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Surgery, University of Chicago Medical Center, Transplantation Institute, 5841 S. Maryland Ave. MC5027, Room J-517, Chicago, IL, 60637, USA.

Introduction: We assessed whether positive microbiological cultures from the islet preparation had any effect on the risk of infectious complications (IC) after total pancreatectomy with islet autotransplantation (TPIAT) in our center.

Methods: We analyzed preservation fluid and final islet product surveillance cultures with reference to clinical data of patients undergoing TPIAT. All patients received routine prophylactic broad-spectrum antibiotics. Read More

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http://dx.doi.org/10.1007/s11605-019-04118-yDOI Listing
February 2019
10 Reads

A Toddler With Prolonged Fever and Intermittent Cough.

Glob Pediatr Health 2019 23;6:2333794X18822999. Epub 2019 Jan 23.

Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Fever of unknown origin is an important diagnostic challenge in pediatrics that requires a thoughtful approach. The differential diagnosis is broad and includes infectious, autoimmune, oncologic, neurologic, genetic, and iatrogenic causes. Infection remains the most common etiology, and uncommon presentations of infections are still more likely than classic presentations of rare conditions. Read More

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http://dx.doi.org/10.1177/2333794X18822999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348535PMC
January 2019
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Proposal for a simple algorithm to differentiate adult-onset Still's disease with other fever of unknown origin causes: a longitudinal prospective study.

Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine, Division of Rheumatology, Hacettepe University Medical School, Sihhiye, 06100, Ankara, Turkey.

Objective: To identify several clinical and/or laboratory parameters which can differentiate adult-onset Still's disease (AOSD) from other causes of fever of unknown origin (FUO) and create a clinician-friendly algorithm for this purpose.

Methods: FUO patients hospitalized between March 2015 and September 2017 were recruited prospectively. AOSD patients diagnosed between 2001 and 2017 in our department were analyzed. Read More

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http://dx.doi.org/10.1007/s10067-019-04455-yDOI Listing
February 2019
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[Clinical analysis of neuromyelitis optica spectrum disorders in childhood].

Zhonghua Er Ke Za Zhi 2019 Feb;57(2):118-124

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To explore clinical features and the effect of treatment of neuromyelitis optica spectrum disorders (NMOSD) in childhood. Children who were hospitalized in Department of Pediatrics, Peking University First Hospital from January 2013 to June 2018 and meeting diagnostic criteria of NMOSD proposed by the International Panel for NMOSD Diagnosis in 2015 were summarized and followed up. The basic information, symptoms of each attack, locations and patterns of new lesions, features of cerebrospinal fluid, serologic markers, treatments and outcomes in these patients were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.02.011DOI Listing
February 2019
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A Clinical Report of Two Cases of Cryptogenic Brain Abscess and a Relevant Literature Review.

Front Neurosci 2018 14;12:1054. Epub 2019 Jan 14.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.

Brain abscess, a severe intracranial infectious disease, refers to the parenchyma abscess caused by local infection or remote spread. Recently, advancements in modern medicine, especially the wide application of antimicrobial drugs, have contributed to the gradual decrease in the prevalence of this disease. However, cases of cryptogenic brain abscess that feature an unknown origin and atypical symptoms are rising. Read More

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http://dx.doi.org/10.3389/fnins.2018.01054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339901PMC
January 2019
4 Reads

A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):63-65

Department of Pediatrics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Isolated sphenoid sinusitis is a rare disorder and may present with severe complications due to its proximity to the orbital and intracranial areas. We report a 13-year-old boy hospitalized for septic shock with fever of unknown origin. Facial palsy was later noted. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_1_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334571PMC
January 2019
3 Reads

Management of febrile neutropenia in the perspective of antimicrobial de-escalation and discontinuation.

Expert Rev Anti Infect Ther 2019 Jan 28:1-13. Epub 2019 Jan 28.

d Department of Hematology and Oncology, Medical Center , Otto-von-Guericke University , Magdeburg , Germany.

Introduction: Infections are among the most frequent complications in patients with hematological and oncological diseases. They might be classified as fever of unknown origin and microbiologically or clinically documented infections. Optimal duration of antimicrobial treatment is still unclear in these patients. Read More

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http://dx.doi.org/10.1080/14787210.2019.1573670DOI Listing
January 2019