242,995 results match your criteria Fever in the Neonate and Young Child

Recurrent parvovirus B19 viremia resulting in two episodes of hemophagocytic lymphohistiocytosis.

Virol J 2022 Jun 25;19(1):107. Epub 2022 Jun 25.

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition with uncontrolled activation of lymphocytes and macrophages. Besides a primary (genetic) form, HLH can also be triggered by malignant, autoimmune and infectious diseases. HLH recurrences are rarely described, usually only in primary HLH. Read More

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Symptom control and survival for people severely ill with COVID: a multicentre cohort study (CovPall-Symptom).

J Pain Symptom Manage 2022 Jun 22. Epub 2022 Jun 22.

International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, UK.

Context: Evidence of symptom control outcomes in severe COVID is scant.

Objective: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival.

Methods: Multicentre cohort study of people with COVID across England and Wales supported by palliative care services, during the pandemic in 2020 and 2021. Read More

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Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF-α secretion.

Biochim Biophys Acta Mol Basis Dis 2022 Jun 22:166472. Epub 2022 Jun 22.

BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address:

During the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. Read More

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A recent chikungunya outbreak associated with the occurrence of Aedes vectors (Diptera: Culicidae) in Kassala state, eastern Sudan in 2018.

Parasitol Int 2022 Jun 22:102613. Epub 2022 Jun 22.

Entomology Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

Aedes aegypti and Ae. albopictus (Diptera: Culicidae) are primary vectors of human arboviral diseases such as dengue, chikungunya, yellow fever, and Zika viruses. Aedes aegypti is well distributed in Sudan, except in Northern and Khartoum states, while Ae. Read More

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A case report of ulceroglandular tularemia caused by Francisella tularensis subsp. holarctica in Iran.

Acta Trop 2022 Jun 22:106570. Epub 2022 Jun 22.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: Tularemia is a zoonotic disease that has been reported in many countries of the Northern Hemisphere. However, in some countries, such as Iran, this disease has been neglected by the health care system, and it is under-reported.

Case Presentation: Here we report an unusual case of ulceroglandular tularemia occurring in a 35-year-old woman who presented with a skin lesion of the left flank, inguinal lymphadenopathy, and an abdominal abscess. Read More

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Immunoassay for quantification of antigen-specific IgG fucosylation.

EBioMedicine 2022 Jun 22;81:104109. Epub 2022 Jun 22.

Department of Experimental Immunohematology, Sanquin Research, Amsterdam, the Netherlands; Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands. Electronic address:

Background: Immunoglobulin G (IgG) antibodies serve a crucial immuno-protective function mediated by IgG Fc receptors (FcγR). Absence of fucose on the highly conserved N-linked glycan in the IgG Fc domain strongly enhances IgG binding and activation of myeloid and natural killer (NK) cell FcγRs. Although afucosylated IgG can provide increased protection (malaria and HIV), it also boosts immunopathologies in alloimmune diseases, COVID-19 and dengue fever. Read More

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Skin involvement in Francisella tularensis infection: a case report of two clinical cases.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):89-92

Department of Infectious Diseases, University Medical Center Maribor, Maribor, Slovenia.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. Read More

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Early report on the severity of COVID-19 in hematologic patients infected with the SARS-CoV2 omicron variant.

Eur J Haematol 2022 Jun 25. Epub 2022 Jun 25.

Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Patients with hematologic disease are at high risk of morbidity and mortality from COVID-19 due to disease-inherent and therapy-related immunodeficiency. Whether infection with the SARS-CoV2 omicron variant leads to attenuated disease severity in these patients is currently unknown. Here, we report on the clinical spectrum and outcomes of 61 omicron-infected hematologic patients. Read More

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Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Building 9312, Henrik Harpestrengs Vej 4C, 2100 Copenhagen, Denmark.

Aims: To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs).

Methods And Results: A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker. Read More

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pneumonia in a patient receiving chemotherapy for advanced prostatic cancer: a case report.

J Int Med Res 2022 Jun;50(6):3000605221105358

Department of Pulmonary Medicine and Critical Medicine, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

pneumonia (PJP) in advanced prostatic cancer patients not receiving high-dose glucocorticoids has been reported rarely. A 73-year-old man underwent chemotherapy with cisplatin and docetaxel for advanced prostatic cancer. After nine cycles of chemotherapy, he developed a high fever, dry cough, shortness of breath, and severe fatigue, with rapid-onset hypoxic respiratory failure. Read More

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Effect of percutaneous nephrolithotripsy under guidance of B-ultrasound for the treatment of complex renal calculi.

J Pak Med Assoc 2022 Jun;72(6):1198-1200

Department of Urology, The Second Affiliated Hospital of Guilin Medical College China.

The purpose of this study was to investigate the effect of percutaneous nephrolithotripsy guided by B-ultrasound in the treatment of complex renal calculi. A total of 82 patients with complex renal calculi were selected, who underwent percutaneous nephrolithotripsy guided by B-ultrasound. The average operation time was 101. Read More

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Short- and long-term mortality in patients with urosepsis caused by Escherichia coli susceptible and resistant to 3rd generation cephalosporins.

BMC Infect Dis 2022 Jun 24;22(1):571. Epub 2022 Jun 24.

Infectious Disease Unit, Wolfson Medical Center, 62 Halochamim Street, 58100, Holon, Israel.

Background: The aim of this study was to compare short- and long-term mortality among patients with urosepsis caused by Escherichia coli susceptibile (EC-SC) and resistant (EC-RC) to 3rd generation cephalosporins.

Methods: A retrospective cohort study that included all patients with E. coli urosepsis admitted to a 700-bed hospital from January 2014 until December 2019. Read More

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A Cross-Sectional Study of Untoward Reactions Following Homologous and Heterologous COVID-19 Booster Immunizations in Recipients Seventeen Years of Age and Older.

J Community Health 2022 Jun 25. Epub 2022 Jun 25.

Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via De Sanctis, 86100, Campobasso, Italy.

A booster dose after primary COVID-19 vaccination series was considered crucial after the emergence of the B.1.617. Read More

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[Clinical characteristics and vaccination status of SARS-CoV-2 Omicron variant infected children].

Zhonghua Er Ke Za Zhi 2022 Jun 15;60(7):671-675. Epub 2022 Jun 15.

Department of Infection,Tianjin Children's Hospital (Children's Hospital of Tianjin University) Machang Campus, Tianjin 300074, China.

To investigate the clinical characteristics and vaccination status of SARS-CoV-2 Omicron variant infected children. A total of 105 children infected with Omicron variant admitted to Tianjin Haihe Hospital (designated referral hospital for SARS-CoV-2 infection in Tianjin) from January 8, 2022 to February 3 were included for a retrospective study. The cases were divided into pneumonia group and non-pneumonia group according to chest imaging. Read More

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A typhoid fever protein capsular matrix vaccine candidate formulated with Advax-CpG adjuvant induces a robust and durable anti-typhoid Vi polysaccharide antibody response in mice, rabbits and nonhuman primates.

Vaccine 2022 Jun 21. Epub 2022 Jun 21.

Vaxine Pty Ltd, 11 Walkley Avenue, Warradale, Adelaide, Australia; School of Medicine and Public Health, Flinders University, Adelaide, Australia. Electronic address:

Typhax is an investigational typhoid fever vaccine candidate that is comprised of Vi polysaccharide from Salmonella enterica serovar typhi (S. Typhi) non-covalently entrapped in a glutaraldehyde catalyzed, cross-linked α-poly-L-lysine and CRM protein matrix. A previous Phase 1 trial of an aluminum phosphate adjuvanted Typhax formulation showed it induced Vi IgG after a single dose but that subsequent doses failed to further boost Vi IgG levels. Read More

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The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study.

Lancet Microbe 2022 Jun 21. Epub 2022 Jun 21.

Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA. Electronic address:

Background: The emergence of increasingly antimicrobial-resistant Salmonella enterica serovar Typhi (S Typhi) threatens to undermine effective treatment and control. Understanding where antimicrobial resistance in S Typhi is emerging and spreading is crucial towards formulating effective control strategies.

Methods: In this genomic epidemiology study, we sequenced the genomes of 3489 S Typhi strains isolated from prospective enteric fever surveillance studies in Nepal, Bangladesh, Pakistan, and India (between 2014 and 2019), and combined these with a global collection of 4169 S Typhi genome sequences isolated between 1905 and 2018 to investigate the temporal and geographical patterns of emergence and spread of antimicrobial-resistant S Typhi. Read More

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Estimating typhoid incidence from community-based serosurveys: a multicohort study.

Lancet Microbe 2022 Jun 21. Epub 2022 Jun 21.

Center for Celiac Research and Treatment, MassGeneral Hospital for Children, Boston, MA, USA; Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA, USA; Harvard Medical School, Harvard University, Boston, MA, USA.

Background: The incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim of this study was to evaluate whether new diagnostic serological markers for typhoidal Salmonella can reliably estimate population-level incidence.

Methods: We collected longitudinal blood samples from patients with blood culture-confirmed enteric fever enrolled from surveillance studies in Bangladesh, Nepal, Pakistan, and Ghana between 2016 and 2021 and conducted cross-sectional serosurveys in the catchment areas of each surveillance site. Read More

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Rare case of pelvic schwannoma mimicking intra-ligamenter uterine fibroid: A case report.

Int J Surg Case Rep 2022 Jun 20;96:107327. Epub 2022 Jun 20.

Division of Oncology Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia.

Introduction And Importance: Schwannomas are benign tumors originating from Schwann cells of nerve fibers. Pelvic schwannomas are extremely rare. Here, we present a case of a 48-year-old woman with a pelvic schwannoma imitating degenerating cystic leiomyoma. Read More

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Ischemic stroke in patients that recover from COVID-19: Comparisons to historical stroke prior to COVID-19 or stroke in patients with active COVID-19 infection.

PLoS One 2022 24;17(6):e0270413. Epub 2022 Jun 24.

University of Alberta, Edmonton, Alberta, Canada.

Background And Purpose: Understanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic historical stroke (Pre-C), cases in acute COVID infection (Active-C) and in patients who have recovered from COVID-19 infection (Post-C).

Methods: We interrogated the Qatar stroke database for all stroke admissions between Jan 2019 and Feb 2020 (Pre-C) to Active-C (Feb2020-Feb2021) and Post-C to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak. Read More

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The prevalence of AstraZeneca COVID-19 vaccine side effects among Nigist Eleni Mohammed memorial comprehensive specialized hospital health workers. Cross sectional survey.

PLoS One 2022 24;17(6):e0265140. Epub 2022 Jun 24.

Department of Dentistry, College of Medicine and Health Sciences, Wachemo University, Hosanna, Ethiopia.

Introduction: The best way to eradicate corona virus disease (COVID-19) viral infection is mass vaccination. Many studies demonstrate vaccination is associated with some local and systemic side effects. This study aimed to provide evidence on AstraZeneca COVID-19 vaccine side effects. Read More

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Bartonella quintana Infection in People Experiencing Homelessness in the Denver Metropolitan Area.

J Infect Dis 2022 Jun 24. Epub 2022 Jun 24.

Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, U.S.A.

Background: Bartonella quintana is an important cause of infection amongst people experiencing homelessness that is underdiagnosed due to its non-specific clinical manifestations. We reviewed cases identified in the Denver Metropolitan Area from 2016-2021.

Methods: The electronic medical records from two large academic medical centers in Colorado were reviewed for demographic, clinical, and laboratory features of patients with B. Read More

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Serum Brain-Derived Neurotrophic Factor (BDNF) in COVID-19 Patients and its Association with the COVID-19 Manifestations.

J Mol Neurosci 2022 Jun 24. Epub 2022 Jun 24.

Department of Microbiology, Parasitology, and Immunology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

COVID-19 is a systematic disease that frequently implies neurological and non-neurological manifestations, predominantly by inducing hypoxia. Brain-derived neurotrophic factor (BDNF) is a key factor in regulating functions of nervous and respiratory systems and has been strongly related to hypoxia. Therefore, this study planned to investigate BDNF association with the COVID-19 manifestations especially neurological impairments and the infection-induced hypoxia. Read More

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Prognostic impact of C-reactive protein and alpha-fetoprotein in immunotherapy score in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab: a multicenter retrospective study.

Hepatol Int 2022 Jun 24. Epub 2022 Jun 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

Aim: This study aimed to investigate the utility of C-reactive protein (CRP) and alpha-fetoprotein (AFP) in immunotherapy (CRAFITY) score in hepatocellular carcinoma (HCC) patients receiving atezolizumab and bevacizumab (Atez/Bev).

Methods: This retrospective cohort study included a total of 297 patients receiving Atez/Bev from September 2020 to November 2021 at 21 different institutions and hospital groups in Japan. Patients with AFP ≥ 100 ng/mL and those with CRP ≥ 1 mg/dL were assigned a CRAFITY score of 1 point. Read More

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Antibiotic Use and Stewardship Practices in a Pediatric Community-Based Cohort Study in Peru: Shorter Would be Sweeter.

Clin Infect Dis 2022 Jun 24. Epub 2022 Jun 24.

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.

Background: There is a need to evaluate antibiotic use, duration of therapy and stewardship in low- and middle-income countries to guide the development of appropriate stewardship programs that are global in scope and effectively decrease unnecessary antibiotic use.

Methods: We prospectively collected information on illness occurrence and antibiotic use from a cohort of 303 children. We evaluated the incidence, duration of therapy and appropriateness of antibiotic prescriptions by five main antibiotic prescribers (physicians and nurses, pharmacists, nursing assistants, self-prescriptions and neighbors or family members). Read More

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Epidemiology of Kawasaki Disease in children in Switzerland: a national prospective cohort study.

Swiss Med Wkly 2022 May 26;152:w30171. Epub 2022 May 26.

Division of Pediatric Cardiology, Department of women-mother-child, Lausanne University Hospital, Lausanne, Switzerland.

Aim Of The Study: Kawasaki disease is a febrile illness which can lead to significant coronary artery lesions. Its incidence varies among countries and is highest in Japan (330.2 children under 5 years old/100,000 per year). Read More

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Safety and risk of febrile recurrence after early antibiotic discontinuation in high-risk neutropenic patients with haematological malignancies: a multicentre observational study.

J Antimicrob Chemother 2022 Jun 24. Epub 2022 Jun 24.

Department of Infectious Diseases, University Hospital of Nantes and CIC 1413, Nantes, France.

Background: Early antibiotic discontinuation according to the Fourth European Conference on Infections in Leukaemia (ECIL-4) recommendations is not systematically applied in high-risk neutropenic patients with haematological malignancies.

Methods: A retrospective multicentre observational study was conducted over 2 years to evaluate the safety of early antibiotic discontinuation for fever of unknown origin (FUO) during neutropenia after induction chemotherapy or HSCT, in comparison with a historical cohort. We used Cox proportional hazards models, censored on neutropenia resolution, to analyse factors associated with febrile recurrence. Read More

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Acute gastrointestinal graft-versus-host disease with CMV and EBV superinfection in a patient with COVID-19.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastroenterology , Centro Hospitalar Universitário de São João, Portugal.

A 60-year-old female was diagnosed with acute myeloid leukemia. After initial remission with chemotherapy, she relapsed and underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two months later, she presented to emergency department with watery diarrhea, abdominal pain and fever. Read More

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Evaluation of the tolerability of monoclonal antibody therapy for pregnant patients with COVID-19.

J Obstet Gynaecol Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Mie University Faculty Medicine, Mie, Japan.

Aim: To evaluate the tolerability of casirivimab and imdevimab (CAS/IMB) therapy in pregnant women with COVID-19 in Japan and its impact on the neonate and process of delivery.

Methods: Eight cases of pregnancy complicated by COVID-19 and requiring hospitalization during the delta variant epidemic were included. Gestational age, initial symptoms, pregnancy complications and outcome, severity of illness, blood test findings at the time of treatment initiation and on days 3-5 after administration, body temperature at administration, and 8, 24, and 48 h post-administration, delivery outcome, and neonatal findings were recorded. Read More

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Neonates with SARS-CoV-2 infection: spectrum of disease from a prospective nationwide observational cohort study.

Swiss Med Wkly 2022 May 27;152:w30185. Epub 2022 May 27.

Paediatrics and Paediatric Infectious Diseases, Children's Hospital Lucerne, Cantonal Hospital Lucerne, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) can be more severe in infants than in older children. To date, only a few case series have reported data on neonates with COVID-19, including mostly asymptomatic neonates who were tested because of exposure to maternal SARS-CoV-2 infection. This study summarises nationwide epidemiological data, clinical characteristics, treatment and outcomes of neonates presenting with symptomatic SARS-CoV-2 infection. Read More

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