216,992 results match your criteria Fever in the Neonate and Young Child


Genotypes of Epstein-Barr virus (EBV1/EBV2) in individuals with infectious mononucleosis in the metropolitan area of Belém, Brazil, between 2005 and 2016.

Braz J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Universidade Federal do Pará, Núcleo de Medicina Tropical, Belém, PA, Brazil; Instituto Evandro Chagas, Pós-Graduação em Virologia, Ananindeua, PA, Brazil.

Two types of Epstein Barr virus (EBV1/EBV2) have been shown to infect humans. Although their genomes are similar, the regions containing the EBNA genes differ. This study aimed to characterize the EBV genotypes of infectious mononucleosis (IM) cases in the metropolitan region of Belém, Brazil, from 2005 to 2016. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.06.004DOI Listing

Anakinra And Etanercept Combination Treatment in a Child With Severe, Nonresponsive Kawasaki Disease.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pediatric Cardiology and Pediatric Intensive Care, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Kawasaki disease (KD) patients' resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. Read More

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http://dx.doi.org/10.1097/INF.0000000000002810DOI Listing

Considerations for the otolaryngologist in the era of COVID-19: a review of the literature.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology - Head and Neck Surgery.

Purpose Of Review: The SARS-CoV-2 coronavirus pandemic, referred to as COVID-19, has spread throughout the globe since its first case in China in December 2019, leaving a significant number of people infected and clinically ill. The purpose of this review is to provide the current known clinical characteristics of and management for COVID-19 as it relates to otolaryngology.

Recent Findings: COVID-19 is a highly transmissible respiratory disease with common presenting symptoms of fever, cough, and fatigue. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000632DOI Listing

GABA-B Receptor Encephalitis Triggered by Enterovirus Encephalitis in a Patient With Small Cell Lung Cancer: A Case Report.

Neurologist 2020 Jul;25(4):106-108

Department of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Introduction: Encephalitis with gamma-aminobutyric acid (GABA)-B receptor antibodies (GABA-B receptor encephalitis) is known to have underlying neoplastic condition in half of the cases; however, there could be an additional event that could work as a trigger factor. Here, we report a patient with GABA-B receptor encephalitis associated with small cell lung cancer, which was probably triggered by enterovirus encephalitis.

Case Report: A 53-year-old man was admitted for a seizure, following fever and headache for 3 days. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000283DOI Listing

Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19).

Obstet Gynecol 2020 Jun 30. Epub 2020 Jun 30.

Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, the Division of Infectious Disease, Department of Internal Medicine, and the Department of Internal Medicine, Cedars Sinai Medical Center, Los Angeles, California.

Background: There are limited data regarding treatment options for pregnant women with severe coronavirus disease 2019 (COVID-19).

Case: A 35-year-old primigravid patient at 22 weeks of gestation presented with 7 days of fever, cough, anosmia, and dyspnea. Nasopharyngeal swab was positive for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and a chest X-ray demonstrated bilateral patchy infiltrates. Read More

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http://dx.doi.org/10.1097/AOG.0000000000004050DOI Listing

High neutralizing antibody titer in intensive care unit patients with COVID-19.

Emerg Microbes Infect 2020 Jul 3:1-30. Epub 2020 Jul 3.

AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Coronavirus disease 2019 (COVID-19) has a wide spectrum of disease severity from mild upper respiratory symptoms to respiratory failure. The role of neutralizing antibody (NAb) response in disease progression remains elusive. This study determined the seroprevalence of 733 non-COVID-19 individuals from April 2018 to February 2020 in the Hong Kong Special Administrative Region and compared the neutralizing antibody (NAb) responses of eight COVID-19 patients admitted to the intensive care unit (ICU) with those of 42 patients not admitted to the ICU. Read More

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http://dx.doi.org/10.1080/22221751.2020.1791738DOI Listing

The Covid-19 pandemic seen from the frontline.

Int Braz J Urol 2020 Jun 5;46. Epub 2020 Jun 5.

Emergency Service, Sierrallana Hospital, Cantabria, Spain.

COVID-19 disease caused by infection with the SARS-CoV-2 virus produces respiratory symptoms, predominantly of the upper airways, which can progress to pneumonia after 7 days with persistent fever, cough and dyspnea, and even develop a syndrome of acute respiratory distress (ARDS), multi-organ failure and death. Since COVID-19 disease was declared by the WHO there has been a redistribution of the healthcare system for these types of patients, especially in the front line, which is, in primary care, emergencies and in intensive care units (ICU). In primary care, the fundamental role is the diagnosis of the suspected patients, follow-up mainly by telemedicine (specially telephone calls) to detect warning signs in case of worsening and subsequent referral to the emergency department; as well as explaining home isolation measures. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2020.S123DOI Listing

How to handle the main drugs to treat autoinflammatory disorders and how we treat common autoinflammatory diseases.

G Ital Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Division of Pediatric Rheumatology, Bicêtre Hospital, APHP, University of Paris Sud Saclay, Le Kremlin-Bicêtre, France.

This article provides an overview of the main drugs to treat autoinflammatory disorders focusing on the four emblematic diseases within this group which represent, to date, the vast majority of patients with monogenic SAID; i.e. familial Mediterranean fever, mevalonate kinase deficiency, TNF receptor 1 deficiency and cryopyrin-associated periodic syndrome. Read More

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http://dx.doi.org/10.23736/S0392-0488.20.06708-5DOI Listing

Feasibility, Reproducibility, and Clinical Validity of a Quantitative Chest X-Ray Assessment for COVID-19.

Am J Trop Med Hyg 2020 Jul 2. Epub 2020 Jul 2.

Department of Radiology, ASST Fatebenefratelli Sacco, Milan, Italy.

Chest X-ray (CXR) is an essential first-line tool in COVID-19 pneumonia diagnosis and management. Our study aimed at assessing 1) CXR manifestations, frequency, and distribution; 2) the feasibility and repeatability of a CXR severity score; and 3) the correlation between the CXR severity score and clinical and laboratory parameters. We reviewed baseline CXRs and clinical data of consecutive patients who presented to our emergency department and resulted positive at SARS-CoV-2 reverse transcriptase-PCR oropharyngeal swab test from March 1, 2020 to April 6, 2020. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0535DOI Listing

Review of Burden, Clinical Definitions, and Management of COVID-19 Cases.

Am J Trop Med Hyg 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine, University of Melbourne, Melbourne, Australia.

Our understanding of SARS-CoV-2, the virus responsible for coronavirus disease 2019 (COVID-19), its clinical manifestations, and treatment options continues to evolve at an unparalleled pace. This review sought to summarize the key literature regarding transmission, case definitions, clinical management, and the burden of COVID-19. Our review of the literature showed that SARS-CoV-2 was mainly transmitted via inhalation of respiratory droplets containing the virus and had a mean incubation period of 4-6 days. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0564DOI Listing

Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.

J Med Virol 2020 Jul 3. Epub 2020 Jul 3.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: We conducted this systemic review and meta-analysis in an attempt to evaluate the efficacy and safety of umifenovir in COVID-19.

Methods: We searched PubMed, Web of Science, Embase, Cochrane Library, CNKI and medRxiv database. We included both retrospective and prospective studies. Read More

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http://dx.doi.org/10.1002/jmv.26256DOI Listing

Mood, anxiety and olfactory dysfunction in COVID-19: evidence of central nervous system involvement?

Laryngoscope 2020 Jul 2. Epub 2020 Jul 2.

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH, USA, 45267.

Introduction: The objective of this study was to determine the burden of depressed mood and anxiety in COVID-19, and associated disease characteristics.

Materials And Methods: This is a prospective, cross-sectional study of 114 COVID-19 positive patients diagnosed using RT-PCR-based testing over a 6-week period. The 2-item Patient Health Questionnaire (PHQ-2) and the 2-item Generalized Anxiety Disorder questionnaire (GAD-2) were used to measure depressed mood and anxiety level, respectively, at enrollment and for participants' baseline, pre-COVID-19 state. Read More

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http://dx.doi.org/10.1002/lary.28964DOI Listing

Necrosis of the Nissen-Sleeve Gastrectomy (N-SG) Wrap.

Obes Surg 2020 Jul 2. Epub 2020 Jul 2.

Whittington Hospital, London, UK.

Background: Sleeve gastrectomy (SG) is the highest performed bariatric procedure in the world. Gastro-oesophageal reflux disease (GERD) is widely debated topics after SG. Nissen-Sleeve gastrectomy (N-SG) technique was reported in 2016 as an alternative solution to this problem. Read More

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http://dx.doi.org/10.1007/s11695-020-04808-6DOI Listing

Identification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited setting.

Arch Virol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine, Faculty of Medicine, University of Kelaniya, P O Box 6, Thalagolla Road, Ragama, GQ, 11010, Sri Lanka.

Only a minority of dengue infections lead to plasma leakage (critical phase [CP]). Early identification of the risk for CP is helpful for triage of patients. This study aimed to identify early clinical predictors of CP that will aid in patient triage during early illness. Read More

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http://dx.doi.org/10.1007/s00705-020-04720-5DOI Listing

Ruxolitinib combined with doxorubicin, etoposide, and dexamethasone for the treatment of the lymphoma-associated hemophagocytic syndrome.

J Cancer Res Clin Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Hematology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangdong, China.

Purpose: Case reports suggest that ruxolitinib-containing treatment could increase the clinical response rate of patients with hemophagocytic syndrome (HPS). This study aimed to explore the effect of ruxolitinib-containing treatment for patients with lymphoma-associated hemophagocytic syndrome (LAHS).

Methods: This was a retrospective study of patients with LAHS hospitalized at the First Affiliated Hospital of Guangdong Pharmaceutical University between October 2017 and September 2019. Read More

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http://dx.doi.org/10.1007/s00432-020-03301-yDOI Listing

Haemophagocytic lymphohistiocytosis after heart transplantation: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Department of Transplant Institute, Sahlgrenska University Hospital, SE-413 25, Gothenburg, Sweden.

Background: Haemophagocytic lymphohistiocytosis (HLH) is an uncommon but serious systemic inflammatory response with high mortality rates. It can be triggered by malignancy or infectious agents, often in the context of immunosuppression. Literature covering HLH in heart transplantation (HTx) is scarce. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319853PMC

Infectious stentitis after treatment of coarctation of the aorta: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-5. Epub 2020 May 3.

Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Background: Aortitis is a rare condition that can be caused by inflammatory or infectious aetiologies. The clinical presentation of aortitis includes a heterogeneous range of symptoms and clinical signs.

Case Summary: We present a 53-year-old man whose medical history included presence of a ventricular septal defect, a bicuspid aortic valve, and coarctation of the aorta. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319810PMC

Diagnostic Value of Chest X-Ray in Patients With Suspected Infection and No Respiratory Signs or Symptoms.

Open Forum Infect Dis 2020 Jun 8;7(6):ofaa221. Epub 2020 Jun 8.

Department of Internal Medicine, Flevoziekenhuis, Almere, the Netherlands.

Suspicion of an infection without localizing signs or symptoms is a common problem. A chest x-ray (CXR) is often performed to rule out pneumonia. Our prospective cross-sectional study suggests that a CXR has no diagnostic value in patients without respiratory signs or symptoms, if a reliable medical history can be obtained. Read More

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http://dx.doi.org/10.1093/ofid/ofaa221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314582PMC

HIV Testing in Adults Presenting With Central Nervous System Infections.

Open Forum Infect Dis 2020 Jun 6;7(6):ofaa217. Epub 2020 Jun 6.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas (UT Health), McGovern Medical School, Houston, Texas, USA.

Background: Universal HIV testing in adults presenting to a health care setting was recommended by the Centers for Disease Control and Prevention (CDC) in 2006, but compliance in central nervous system (CNS) infections is unknown.

Methods: A multicenter study of adults presenting with CNS infections to 18 hospitals in Houston and New Orleans between 2000 and 2015 was done to characterize HIV testing and explore factors associated with a positive HIV test.

Results: A total of 1478 patients with a diagnosis of meningitis or encephalitis were identified; 180 were excluded because of known HIV diagnosis (n = 100) or were <17 years old (n = 80). Read More

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http://dx.doi.org/10.1093/ofid/ofaa217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320826PMC

Rat-Bite Fever in the United States: An Analysis Using Multiple National Data Sources, 2001-2015.

Open Forum Infect Dis 2020 Jun 7;7(6):ofaa197. Epub 2020 Jun 7.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Rat-bite fever is a rare disease associated with rat bites or direct/indirect rodent contact.

Methods: We examined rat-bite fever and rat-bite injury diagnoses in the United States during 2001-2015. We analyzed national, state, and Indian Health Service healthcare encounter datasets for rat-bite fever and rat-bite injury diagnoses. Read More

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http://dx.doi.org/10.1093/ofid/ofaa197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320832PMC

Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.

Open Forum Infect Dis 2020 Jun 26;7(6):ofaa194. Epub 2020 May 26.

Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Background: Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately identify bacterial and viral ARI in cohorts of European and African descent. We determined classifier performance in a South Asian cohort. Read More

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http://dx.doi.org/10.1093/ofid/ofaa194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314590PMC

Safety of Recombinant Influenza Vaccine Compared to Inactivated Influenza Vaccine in Adults: An Observational Study.

Open Forum Infect Dis 2020 Jun 20;7(6):ofaa179. Epub 2020 May 20.

Kaiser Permanente Vaccine Study Center, Oakland, California, USA.

Background: Recombinant trivalent influenza vaccine (RIV3) was initially licensed in 2013 and approved for all adults ≥18 in 2014. This study evaluated the safety of RIV3 compared with trivalent standard-dose, inactivated influenza vaccine (IIV3) in Kaiser Permanente Northern California (KPNC).

Methods: This Phase 4 observational, postmarketing safety study included persons ≥18 years vaccinated with RIV3 or IIV3 in KPNC during the 2015-2016 influenza season. Read More

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http://dx.doi.org/10.1093/ofid/ofaa179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316363PMC

Clinical Characteristics of Children with COVID-19.

AIMS Public Health 2020 6;7(2):258-273. Epub 2020 May 6.

Department of Paediatrics, Dr Gray's Hospital, NHS Grampian, Elgin, Scotland, United Kingdom.

Background: In December 2019, the infection caused by 2019 novel coronavirus (COVID-19) led to an outbreak in Wuhan, situated in the Hubei Province of China. Following this, there has been a rapid increase in the number of cases. On 12th March 2020, there were over 100,000 confirmed cases and almost 4,300 deaths worldwide. Read More

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http://dx.doi.org/10.3934/publichealth.2020022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327402PMC

Retrospective analysis of 1,641 cases of classic fever of unknown origin.

Ann Transl Med 2020 Jun;8(11):690

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3 °C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory investigations. It is a special type of fever and a common disease in internal medicine. Read More

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http://dx.doi.org/10.21037/atm-20-3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327343PMC

Coronavirus disease 2019 (COVID-19): chest CT characteristics benefit to early disease recognition and patient classification-a single center experience.

Ann Transl Med 2020 Jun;8(11):679

Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: The current outbreak of coronavirus disease 2019 (COVID-19), epi-centered in Wuhan, Hubei Province of the China, has become a global health emergency. Several studies from China have recently provided the evidence of epidemiological, clinical, laboratory, and outcomes of COVID-19 patients. Investigation on the role of chest CT in patient screening and management course in a large cohort remains paucity. Read More

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http://dx.doi.org/10.21037/atm-20-2119aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327362PMC

Incidence of intussusception in children less than five years of age: a pre-rotavirus vaccine survey from Iran, 2010-2015.

Med J Islam Repub Iran 2020 29;34:40. Epub 2020 Apr 29.

Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The aim of this study was to determine the baseline statistics of intussusception in the under-five- year age group in Iran to facilitate the monitoring of potential side effects after administration of rotavirus vaccine. This hospital-based historical cohort study reviewed children under 60 months of age with the final diagnosis of intussusception, ICD-10 code K56.1, using census in all hospitals of Tehran, Iran from March 2010-2015. Read More

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http://dx.doi.org/10.34171/mjiri.34.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320972PMC

Lyme Disease and Severe Hyperbilirubinemia: A Rare Presentation of Lyme Disease.

Cureus 2020 May 30;12(5):e8363. Epub 2020 May 30.

Internal Medicine, Saint James School of Medicine, Chicago, USA.

A 39-year-old-man presented to the emergency room with a complaint of febrile jaundice and diffuse arthralgia. The patient had a temperature of 100°F, severe jaundice, and scleral icterus. Laboratory workup showed severe hyperbilirubinemia and elevated serum creatinine, and the rest of the serum chemistry was unremarkable. Read More

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http://dx.doi.org/10.7759/cureus.8363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325384PMC

Brugada Pattern Type 2 Diagnosis Unmasked by Aspiration Pneumonia.

Cureus 2020 May 28;12(5):e8331. Epub 2020 May 28.

Cardiology, Detroit Medical Center, Detroit, USA.

Brugada syndrome (BrS) is a rare autosomal dominant mutation affecting sodium channels. Electrocardiography can show two Brugada patterns (BrP). Type 1 BrP usually causes sudden cardiac arrest (SCA). Read More

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http://dx.doi.org/10.7759/cureus.8331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325341PMC

Hydroxychloroquine-induced Stevens-Johnson syndrome in COVID-19: a rare case report.

Oxf Med Case Reports 2020 Jun 25;2020(6):omaa042. Epub 2020 Jun 25.

Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

The international outbreak of respiratory illness termed coronavirus disease 2019 (COVID-19) began in December 2019 that has affected >0.8 million individuals. Self-limiting respiratory tract involvement, severe pneumonia, multiorgan failure and death are the spectrum of COVID-19. Read More

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http://dx.doi.org/10.1093/omcr/omaa042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315925PMC

Isolation of Oxyberberine and -Sitosterol from Royle Root Bark Extract and Cytotoxicity against Liver and Lung Cancer Cell Lines.

Evid Based Complement Alternat Med 2020 15;2020:2596082. Epub 2020 Jun 15.

Department of Botany, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi 46300, Pakistan.

Royle has been traditionally used to cure rheumatism, eye and ear diseases, malarial fever, diabetes, stomach disorders, and skin diseases. There is a least amount of data available on cytotoxic capacity of from Pakistani origin, so on this basis, the present study was aimed to screen root bark extracts for cytotoxicity against cancer cell lines and isolation of chemical constituents from the most cytotoxic extract. Initial screening of extracts was performed on HepG2 cells at 100 g/mL for 72 hours of treatment by using an MTT assay. Read More

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http://dx.doi.org/10.1155/2020/2596082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315281PMC

Are Symptoms Sufficient in the Decision to Start Antibiotics in Tonsillopharyngitis?

Sisli Etfal Hastan Tip Bul 2020 10;54(2):201-205. Epub 2020 Jun 10.

Department of Family Medicine, University of Health Sciences Turkey, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: Unnecessary use of antibiotics is one of the causes of antibiotic resistance. Rapid Antigen Test (RAT) is recommended to prevent unnecessary use of antibiotics by providing bacteria/virus isolation in patients with tonsillopharyngitis. However, in patients with typical symptoms, false-negative test results may lead to doubt in doctors. Read More

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http://dx.doi.org/10.14744/SEMB.2018.01336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326667PMC

Management of Breast Cancer during the COVID-19 Pandemic.

Sisli Etfal Hastan Tip Bul 2020 10;54(2):132-135. Epub 2020 Jun 10.

Department of General Surgery, Sisli Hamidiye Etfal Medical Practice and Research Center, University of Health Sciences, Istanbul, Turkey.

The novel coronavirus disease (COVID-19) arises from the virus SARS-CoV-2 which is similar to the original SARS virus. The most common symptoms of the COVID-19 infection are fever, coughing and shortness of breath. According to the current data, the primary mode of transmission for the COVID-19 virus is between people through respiratory droplets and contact routes. Read More

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http://dx.doi.org/10.14744/SEMB.2020.23326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326681PMC

Estimation of parasite age and synchrony status in Plasmodium falciparum infections.

Sci Rep 2020 Jul 2;10(1):10925. Epub 2020 Jul 2.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Human malaria parasites have complex but poorly understood population dynamics inside their human host. In some but not all infections, parasites progress synchronously through the 48 h lifecycle following erythrocyte invasion, such that at any one time there is a limited spread of parasites at a particular time (hours) post-invasion. Patients presenting with older parasites, and with asynchronous infections, have been reported to have higher risks of fatal outcomes, associated with higher parasite biomass and multiplication rates respectively. Read More

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http://dx.doi.org/10.1038/s41598-020-67817-6DOI Listing

[Preliminary Study on Clinical Features and CT Findings of Common-type Coronavirus Disease 2019 Patients in Peking Union Medical College Hospital].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Jun;42(3):376-382

Department of Radiology.

To summarize the clinical characteristics and chest CT findings of coronavirus disease 2019(COVID-19)patients in Peking Union Medical College Hospital(PUMCH). A total of 13 patients with COVID-19 confirmed at PUMCH from January 20 to February 6,2020 were selected as the research subjects.Their epidemiological histories,clinical characteristics,laboratory tests,and chest CT findings were analyzed retrospectively. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.12588DOI Listing

Why Semmelweis's doctrine was rejected: evidence from the first publication of his results by Friedrich Wieger, and an editorial commenting on the results.

Br J Hist Sci 2020 Jul 3:1-6. Epub 2020 Jul 3.

Retired physician and independent scholar. Email:

We present English translations of two French documents to show that the main reason for the rejection of Semmelweis's theory of the cause of childbed (puerperal) fever was because his proof relied on the post hoc ergo propter hoc fallacy, and not because Joseph Skoda referred only to cadaveric particles as the cause in his lecture to the Academy of Science on Semmelweis's discovery. Friedrich Wieger (1821-1890), an obstetrician from Strasbourg, published an accurate account of Semmelweis's theory six months before Skoda's lecture, and reported a case in which the causative agent originated from a source other than cadavers. Wieger also presented data showing that chlorine hand disinfection reduced the annual maternal mortality rate from childbed fever (MMR) from more than 7 per cent for the years 1840-1846 to 1. Read More

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http://dx.doi.org/10.1017/S0007087420000229DOI Listing

Hydroxychloroquine efficacy and safety in preventing SARS-CoV-2 infection and COVID-19 disease severity during pregnancy (COVID-Preg): a structured summary of a study protocol for a randomised placebo controlled trial.

Trials 2020 Jul 2;21(1):607. Epub 2020 Jul 2.

ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain.

Objectives: The primary objectives of the study are: 1. To assess the effect of hydroxychloroquine (HCQ) in reducing SARS-CoV-2 viral shedding by PCR in infected pregnant women with mild symptoms. 2. Read More

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http://dx.doi.org/10.1186/s13063-020-04557-yDOI Listing

Epidemiology and genetic diversity of circulating dengue viruses in Medellin, Colombia: a fever surveillance study.

BMC Infect Dis 2020 Jul 2;20(1):466. Epub 2020 Jul 2.

Department of Pathobiological Sciences, University of Wisconsin, 500 Lincoln Dr, Madison, WI, 53706, USA.

Background: Dengue fever is a major public health problem in Colombia. A fever surveillance study was conducted for evaluation of the clinical, epidemiological, and molecular patterns of dengue, prior to Chikungunya and Zika epidemics.

Methods: In November 2011-February 2014, a passive facility-based surveillance was implemented in Santa Cruz Hospital, Medellin, and enrolled eligible febrile patients between 1 and 65 years-of-age. Read More

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http://dx.doi.org/10.1186/s12879-020-05172-7DOI Listing

An insight into the transmission role of insect vectors based on the examination of gene characteristics of African swine fever virus originated from non-blood sucking flies in pig farm environments.

BMC Vet Res 2020 Jul 2;16(1):227. Epub 2020 Jul 2.

Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, No.120, Dongling Road, Shenhe District, Shenyang, 110866, PR China.

Background: Insect vector transmitted pathogens from contaminated environments are a key potential risk for public health. Meanwhile, transmission by non-blood sucking flies needs to be considered. Sequencing and phylogenetic tree analyses were used to study African swine fever virus (ASFV) genes derived from flies collected from pig farms that were infected with ASFV. Read More

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http://dx.doi.org/10.1186/s12917-020-02420-5DOI Listing

Identification of Enterococcus faecalis in a patient with urinary-tract infection based on metagenomic next-generation sequencing: a case report.

BMC Infect Dis 2020 Jul 2;20(1):467. Epub 2020 Jul 2.

Department of Intensive Care Medicine, The Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

Background: Urinary tract infection (UTI) caused by various pathogenic microorganisms is ubiquitous in the parts of the urinary system such as kidney, ureter, bladder, and urethra. Currently, clinical detection of UTI is mainly focused on urine culture; however, the diagnostic value of urine culture remains limited due to the time-consuming procedure and low detection rate, especially in patients who have used antibiotics. Generally, treatment for UTI relies on empirical medication rather than pathogen diagnosis, which leads to the inappropriate use of antimicrobial agents and a significant increase in resistant strains. Read More

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http://dx.doi.org/10.1186/s12879-020-05179-0DOI Listing

[Hepatolienal candidosis as a rare differential diagnosis of disseminated small parenchym lesions].

Dtsch Med Wochenschr 2020 Jul 2;145(13):912-916. Epub 2020 Jul 2.

Klinik für Diagnostische und Interventionelle Radiologie, Uniklinikum Ulm, Ulm.

History:  We report about a 17-year-old patient with the secondary malignancy of acute myeloid leukemia (AML). He developed fever of unclear origin during the hematopoietic stem cell transplantation.History We report about a 17-year-old patient with the secondary malignancy of acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1055/a-1164-0043DOI Listing

Single nucleotide polymorphism (SNP) rs3751143 in P2RX7 is associated with therapy failure in chronic Q fever while rs7125062 in MMP1 is associated with fewer complications.

Clin Microbiol Infect 2020 Jun 29. Epub 2020 Jun 29.

Radboud Expertise Center for Q fever, Radboud Center for Infectious Diseases, Department of Internal Medicine, Division of Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.

Objectives: Chronic Q fever is a persistent infection with the intracellular bacterium Coxiella burnetii. Development of chronic Q fever is associated with single nuclear polymorphisms (SNPs) in genes encoding for pattern recognition receptors, for phagolysosomal pathway components and for matrix metalloproteinases (MMPs). In the current study we evaluated the association of SNPs in these innate immunity and MMP genes with clinical outcomes. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.06.016DOI Listing

House dust microbiota in relation to adult asthma and atopy in a U.S. farming population.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Dept. of Health and Human Services (DHHS), Research Triangle Park (RTP), North Carolina (NC), USA. Electronic address:

Background: Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear.

Objective: To examine associations of house dust microbiota with adult asthma, atopy, and hay fever.

Methods: Vacuumed bedroom dust samples from the homes of 879 participants (average age 62) in the Agricultural Lung Health Study, a case-control study of asthma nested within a farming cohort, were subjected to 16S rRNA amplicon sequencing to characterize bacterial communities. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.013DOI Listing

Knowledge, attitudes and bite prevention practices and estimation of productivity of vector breeding sites using a Habitat Suitability Score (HSS) among households with confirmed dengue in the 2014 outbreak in Dar es Salaam, Tanzania.

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0007278. Epub 2020 Jul 2.

Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Tanzania.

Background: The frequency and magnitude of dengue epidemics has increased dramatically throughout the tropics in the past 40 years due to unplanned urbanization, globalization and lack of effective mosquito control. The commercial capital of Tanzania, Dar es Salaam, is now experiencing regular dengue outbreaks. Three dengue serotypes have been detected in Dar es Salaam (DNV 1, 2 and 3). Read More

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http://dx.doi.org/10.1371/journal.pntd.0007278DOI Listing

Recent influenza activity in tropical Puerto Rico has become synchronized with mainland US.

Influenza Other Respir Viruses 2020 Jul 2. Epub 2020 Jul 2.

Centers for Disease Control and Prevention, San Juan, Puerto Rico.

Background: We used data from the Sentinel Enhanced Dengue Surveillance System (SEDSS) to describe influenza trends in southern Puerto Rico during 2012-2018 and compare them to trends in the United States.

Methods: Patients with fever onset ≤ 7 days presenting were enrolled. Nasal/oropharyngeal swabs were tested for influenza A and B viruses by PCR. Read More

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http://dx.doi.org/10.1111/irv.12744DOI Listing

Fatal complication of sickle cell anemia in an immigrant patient rescued from the mediterranean sea.

Clin Ter 2020 Jul-Aug;171(4):e291-e294

Department Pro.Mi.Se., University of Palermo.

The aim of this case report is to share with the forensic science community the experience of a rare complication of sickle cell anemia: acute chest syndrome. In October 2016, at the port of the city of Trapani (Sicily, Italy), the landing of an ONG "Médecins Sans Frontières" ship took place with 548 non-EU citizens and a corpse on board. The man, in the hours before his death, complained of severe chest pain and respiratory difficulties, and, despite of the therapeutic aids and resuscitation maneuvers, lastly died. Read More

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http://dx.doi.org/10.7417/CT.2020.2230DOI Listing

Do All Colchicine Preparations Have the Same Effectiveness in Patients with Familial Mediterranean Fever?

Mod Rheumatol 2020 Jul 2:1-11. Epub 2020 Jul 2.

Dr Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Department of Pediatric Rheumatology Ankara, Turkey.

AimColchicine is the primary treatment for familial Mediterranean fever (FMF). Several colchicine preparations are currently using available globally. This study aimed to describe the demographic, clinical, and genetic features of FMF patients treated with multiple colchicine preparations. Read More

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http://dx.doi.org/10.1080/14397595.2020.1790139DOI Listing

Mitigating the risk of African swine fever virus in feed with antiviral chemical additives.

Transbound Emerg Dis 2020 Jul 2. Epub 2020 Jul 2.

Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America.

African swine fever (ASF) is currently considered the most significant global threat to pork production worldwide. Disease caused by the ASF virus (ASFV) results in high case fatality of pigs. Importantly, ASF is a trade-limiting disease with substantial implications on both global pork and agricultural feed commodities. Read More

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http://dx.doi.org/10.1111/tbed.13699DOI Listing

Chik sign in chikungunya fever.

Infection 2020 Jul 1. Epub 2020 Jul 1.

Department of Dermatology, Venereology, and Leprosy, R.G.Kar Medical College, 1, Khudiram Bose Sarani, West Bengal, 700004, Kolkata, India.

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http://dx.doi.org/10.1007/s15010-020-01472-xDOI Listing

Rapid Screening and Identification of Chemical Constituents From Ophiopogon japonicus by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.

J Chromatogr Sci 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.

Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), which is named as "Maidong" in China, is widely used in traditional Chinese medicine for treating fever, cough, inflammation, epistaxis, constipation, respiratory disease and gastrointestinal disorders. However, the systematic analysis of chemical constituents of O. Read More

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http://dx.doi.org/10.1093/chromsci/bmaa029DOI Listing

Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis.

Heliyon 2020 Jun 20;6(6):e04248. Epub 2020 Jun 20.

Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.

Background: Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322251PMC