435,123 results match your criteria Fetal and Pediatric Pathology [Journal]


New evidences and clarifications by world leaders in maternal fetal medicine.

Authors:
Giovanni Sisti

Minerva Ginecol 2018 Dec 14. Epub 2018 Dec 14.

Department of Health Sciences, AOU Careggi, University of Florence, Florence, Italy -

View Article
December 2018
1 Read

Fetal Echocardiographic Measures to Improve the Prenatal Diagnosis of Coarctation of the Aorta.

Pediatr Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Pediatric Cardiology, Yale School of Medicine, 333 Cedar St, LLCI 302, New Haven, CT, 06510, USA.

The objective of this study is to identify fetal echocardiographic measures that predict postnatal coarctation of the aorta (CoA). A retrospective review of patients from 2013 to 2017 identified 13 cases of prenatal diagnosis of CoA confirmed postnatally and 14 cases of prenatal diagnosis of CoA with normal arches postnatally. There were 30 controls. Read More

View Article
December 2018
1 Read

The spectrum of cloacal malformations: how to differentiate each entity prenatally with fetal MRI.

Pediatr Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Diagnostic Radiology, Division of Pediatric Radiology,, Children's Hospital Colorado,, 13123 East 16th Ave., Mailbox B-463,, Aurora, CO, 80045, USA.

The term cloacal malformation is commonly used to describe the classic cloacal malformation where there is a single common urogenital and intestinal channel located at the expected site of the urethra. There is, however, a spectrum of cloacal abnormalities that differ from this classic type and are less well discussed in the radiologic and surgical literature. The aim of this pictorial essay is to familiarize radiologists with the anatomy, appropriate terminology and key prenatal imaging findings that differentiate the six entities that constitute the spectrum of cloacal abnormalities. Read More

View Article
December 2018
1 Read

Exploration of the regulation and control mechanisms of miR-145 in trophoblast cell proliferation and invasion.

Exp Ther Med 2018 Dec 23;16(6):5298-5304. Epub 2018 Oct 23.

Department of Obstetrics, Huai'an First People's Hospital, Huai'an, Jiangsu 223300, P.R. China.

Preeclampsia (PE) is the leading cause of maternal and fetal mortality and morbidity. Furthermore, recent studies have reported that miR-145 within the preeclamptic trophoblast debris may cause the high blood pressure via interacting with the maternal endothelium. The aim of the present study was to investigate the functions of miR-145 in PE. Read More

View Article
December 2018

Regulation of matrix metalloproteinase-3 gene expression in inflammation: A molecular study.

J Conserv Dent 2018 Nov-Dec;21(6):592-596

Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Introduction: Matrix metalloproteinases (MMPs) play a significant role in the efficient tissue turnover and remodeling. This study focuses on the regulation of the MMPs by the protein kinases at the level of gene expression and their signaling pathways.

Materials And Methods: Lipopolysaccharide-induced murine macrophage-like RAW 264. Read More

View Article
December 2018

Spatiotemporal transcriptomic divergence across human and macaque brain development.

Science 2018 Dec 13;362(6420). Epub 2018 Dec 13.

Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.

Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a late fetal-to-infancy (perinatal) convergence. Read More

View Article
December 2018

Integrative functional genomic analysis of human brain development and neuropsychiatric risks.

Science 2018 Dec;362(6420)

To broaden our understanding of human neurodevelopment, we profiled transcriptomic and epigenomic landscapes across brain regions and/or cell types for the entire span of prenatal and postnatal development. Integrative analysis revealed temporal, regional, sex, and cell type-specific dynamics. We observed a global transcriptomic cup-shaped pattern, characterized by a late fetal transition associated with sharply decreased regional differences and changes in cellular composition and maturation, followed by a reversal in childhood-adolescence, and accompanied by epigenomic reorganizations. Read More

View Article
December 2018
1 Read

Transcriptome and epigenome landscape of human cortical development modeled in organoids.

Science 2018 Dec;362(6420)

Genes implicated in neuropsychiatric disorders are active in human fetal brain, yet difficult to study in a longitudinal fashion. We demonstrate that organoids from human pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception. A multiomics analysis revealed differentially active genes and enhancers, with the greatest changes occurring at the transition from stem cells to progenitors. Read More

View Article
December 2018
1 Read

An analysis of online pregnancy message boards: Mother-to-mother advice on medication use.

Women Birth 2018 Dec 10. Epub 2018 Dec 10.

Department of Athletics, Georgetown University, 37th Street Northwest, Washington, DC 20007, United States.

Problem And Background: Psychotropic medication use is increasingly common among pregnant women. Many women solicit information from other mothers about the safety of these medications for use during pregnancy, yet little is known about the specific advice they receive.

Aim: The purpose of the current study was to examine the type of feedback women receive on a popular internet message board about psychotropic medication use during pregnancy. Read More

View Article
December 2018
1 Read

In reply.

Int J Obstet Anesth 2018 Nov 17. Epub 2018 Nov 17.

The University of Queensland, Faculty of Medicine and Department of Obstetrics and Gynaecology and Obstetric Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

View Article
November 2018

Neuraxial labor analgesia, obstetrical outcomes, and the Robson 10-Group Classification.

Int J Obstet Anesth 2018 Nov 27. Epub 2018 Nov 27.

Department of Anesthesiology and Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, USA.

View Article
November 2018

Fetal distress and urgent cesarean delivery due to new-onset peripartum Crohn's disease.

Taiwan J Obstet Gynecol 2018 Dec;57(6):901-902

Department of Gastroenterology, Shaare Zedek Medical Center, Hebrew University Medical School of Jerusalem, Jerusalem, Israel.

View Article
December 2018

Prenatal diagnosis of coarctation of the aorta with ventricular septal defect: A case report.

Taiwan J Obstet Gynecol 2018 Dec;57(6):885-889

Taiji Clinic, Taipei, Taiwan. Electronic address:

Objective: To present an accurate prenatal diagnosis of coarctation of the aorta with ventricular septal defect and to illustrate how early diagnosis in prenatal period with proper referral and counseling can optimize management.

Case Report: A case with coarctation of the aorta with ventricle septal defect was found to have an abnormal three vessel view at 12 weeks, and with close follow-ups, coarctation of the aorta with ventricle septal defect was diagnosed at 24 weeks. Following the support from a multidisciplinary team that provided counseling, diagnosis, and follow-ups, the pregnant woman decided to continue with the pregnancy and had a vaginal delivery at a medical center. Read More

View Article
December 2018
1 Read

Digynic triploidy in a fetus presenting with semilobar holoprosencephaly.

Taiwan J Obstet Gynecol 2018 Dec;57(6):881-884

Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Bioengineering, Tatung University, Taipei, Taiwan.

Objective: We present digynic triploidy in a fetus with semilobar holoprosencephaly (HPE).

Case Report: A 32-year-old, gravid 1, para 0, woman underwent prenatal ultrasound examination at 12 weeks of gestation, and the ultrasound showed relative macrocephaly, a small non-cystic placenta, and a fetus with absent nasal bone and semilobar HPE. The pregnancy was terminated subsequently, and a 50-g fetus was delivered with a relatively enlarged head and premaxillary agenesis. Read More

View Article
December 2018

A case control study of risk factors and neonatal outcomes of preterm birth.

Taiwan J Obstet Gynecol 2018 Dec;57(6):814-818

Clinical Medical College, Yangzhou University, Yangzho, 225001, Jiangsu, China; Department of Gynecology and Obstetrics, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China. Electronic address:

Objective: The aim is to examine risk factors and neonatal outcomes of preterm birth and to provide basis in preventing preterm birth.

Materials And Methods: we carried out our study on 1328 term controls and 1328 preterm birth cases. By using multivariable logistic regression procedures we estimated odds ratio (OR) of potential preterm birth risk factors. Read More

View Article
December 2018
1 Read

Magnitude of fetal macrosomia and its associated factors at public health institutions of Hawassa city, southern Ethiopia.

BMC Res Notes 2018 Dec 13;11(1):888. Epub 2018 Dec 13.

School of Public Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Objectives: This study aimed to determine the magnitude of fetal macrosomia and associated factors at public health institutions of Hawassa city, southern Ethiopia.

Results: In this study, the magnitude of fetal macrosomia found to be 11.86%. Read More

View Article
December 2018
1 Read

Herbal medicine use by pregnant women in Bangladesh: a cross-sectional study.

BMC Complement Altern Med 2018 Dec 13;18(1):333. Epub 2018 Dec 13.

Institute of Health Services Management, Hanyang University, Seoul, South Korea.

Background: Herbal medicines in pregnancy are increasingly used worldwide with prevalence of up to 67%. Although this popularity is mainly because of the common belief that these medicines are safe, recent reports suggest that several herbal medicines are potentially harmful to mother and fetus if used in pregnancy.

Methods: This cross-sectional study was conducted in July and August of year 2017, at maternity wards of two public hospitals in Dhaka, Bangladesh. Read More

View Article
December 2018

The Prenatal Microbiome: A New Player for Human Health.

High Throughput 2018 Dec 11;7(4). Epub 2018 Dec 11.

CEINGE-BiotecnologieAvanzate, via G. Salvatore via G. Salvatore 486, 80145 Naples, Italy.

The last few years have featured an increasing interest in the study of the human microbiome and its correlations with health status. Indeed, technological advances have allowed the study of microbial communities to reach a previously unthinkable sensitivity, showing the presence of microbes also in environments usually considered as sterile. In this scenario, microbial communities have been described in the amniotic fluid, the umbilical blood cord, and the placenta, denying a dogma of reproductive medicine that considers the uterus like a sterile womb. Read More

View Article
December 2018

Compressive radial neuropathy by a synovial cyst during pregnancy: A clinical case report.

Medicine (Baltimore) 2018 Dec;97(49):e13455

Department of Physical Medicine and Rehabilitation, Tung's Taichung Metroharbor Hospital, Taichung, Taiwan.

Rationale: Compressive radial neuropathy by a synovial cyst in the radial tunnel during pregnancy is a rare occurrence. The management of radial nerve compression caused by a synovial cyst in a pregnant patient is a surgical dilemma owing to the fetal and maternal risks of treatment.

Patient Concerns And Diagnosis: A 37-year-old pregnant woman presented with progressive forearm pain at the gestational age of 12 weeks. Read More

View Article
December 2018
1 Read

Targeted next-generation sequencing identifies a novel mutation of LAMB3 in a Chinese neonatal patient presented with junctional epidermolysis bullosa.

Medicine (Baltimore) 2018 Dec;97(49):e13225

Department of Obstetrics and Gynecology, Wuhan Medical & Health Center for Women and Children, Wuhan, Hubei.

Rationale: Epidermolysis bullosa (EB) refers to a group of rare inherited mechanobullous disorders that present with great clinical and genetic heterogeneity. Its severity ranges from mild blistering to life-threatening. However, the clinical symptoms of different types of EB overlap significantly, especially at an early stage. Read More

View Article
December 2018

Targeting IL-13Rα2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models.

Authors:

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEMalignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that harbor a high potential for metastasis and have a devastating prognosis. Combination chemoradiation aids in tumor control and decreases tumor recurrence but causes deleterious side effects and does not extend long-term survival. An effective treatment with limited toxicity and enhanced efficacy is critical for patients suffering from MPNSTs. Read More

View Article
November 2018

Safety of atovaquone-proguanil during pregnancy.

J Travel Med 2018 Dec 13. Epub 2018 Dec 13.

Malaria Branch, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA USA.

Background: Malaria during pregnancy increases the risk of maternal and fetal complications. There are very limited options available for prophylaxis in pregnant travelers. Atovaquone-Proguanil (AP or Malarone®) is an effective and well-tolerated antimalarial medication, but is not recommended for use in pregnancy due to limited data on safety. Read More

View Article
December 2018

Uterine microbiome-low biomass and high expectations.

Biol Reprod 2018 Dec 13. Epub 2018 Dec 13.

Igenomix Foundation, Instituto de Investigación Sanitaria Hospital Clínico (INCLIVA), Valencia, Spain.

The existence of different bacterial communities throughout the female reproductive tract has challenged the traditional view of human fetal development as a sterile event. There is still no consensus on what physiological microbiota exists in the upper reproductive tract of the vast majority of women who are not in periods of infection or pregnancy, and the role of bacteria that colonize the upper reproductive tract in uterine diseases or pregnancy outcomes is not well established. Despite published studies and advances in uterine microbiome sequencing, some study aspects-such as study design, sampling method, DNA extraction, sequencing methods, downstream analysis, and assignment of taxa-have not yet been improved and standardized. Read More

View Article
December 2018

The unintended effects of place based programs: Fertility and health effects of urban empowerment zones.

Authors:
Daniel Grossman

J Health Econ 2018 Nov 29;63:114-127. Epub 2018 Nov 29.

Department of Economics College of Business and Economics, West Virginia University, Morgantown, WV 26506-6025, United States. Electronic address:

Whether place-based welfare programs affect fertility and health outcomes is an understudied question. I estimate the health impacts of the Empowerment Zone (EZ) program-a federal program that gave sizeable grants and tax breaks to certain high-poverty census tracts in selected cities. Using difference-in-differences methods, I find that the EZ program decreased fertility rates by 11 percent and improved birth outcomes. Read More

View Article
November 2018

Noninvasively diagnosing for fetal trisomy 21 by examining heterozygous single nucleotide polymorphisms in the placental specific genes on chromosome 21.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 12;233:19-25. Epub 2018 Sep 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address:

Objective: Noninvasive prenatal diagnosing for fetal trisomy 21 could help to avoid unnecessary amniocentesis. It is feasible to target the cell-free placental-specific mRNA in maternal plasma, thus eliminating the interference from the maternal genetic background.

Study Design: In this study, placental-specific genes on chromosome 21 were identified by searching the TiGER database and reviewing the published literature. Read More

View Article
September 2018

Indications leading to termination of pregnancy between 22 and 31 weeks of gestational age in France: A population-based cohort study.

Eur J Obstet Gynecol Reprod Biol 2018 Dec 3;233:12-18. Epub 2018 Dec 3.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France.

Objective: To estimate the prevalence and indications of terminations of pregnancy (TOP) between 22 and 31 weeks of gestational age in France and to examine the characteristics of women by indication of TOP.

Study Design: From the EPIPAGE 2 population-based cohort study of preterm births in France in 2011, we selected 5009 singleton live births, stillbirths and TOP that occurred between 22 and 31 weeks. We estimated the proportion of TOP by gestational age. Read More

View Article
December 2018

Neurodevelopmental outcomes in individuals with fetal alcohol spectrum disorder (FASD) with and without exposure to neglect: Clinical cohort data from a national FASD diagnostic clinic.

Alcohol 2018 Jun 12;76:23-28. Epub 2018 Jun 12.

School of Health and Society, University of Salford, Salford, England, United Kingdom.

Disentangling the relative developmental impact of prenatal alcohol exposure from postnatal neglect is clinically valuable for informing future service provision. In this study, developmental outcomes across groups are compared in a 'natural experiment'.

Methods: Clinical data from 99 persons with fetal alcohol spectrum disorder (FASD) diagnoses were audited. Read More

View Article

Field ultrasound evaluation of some gestational parameters in jennies.

Theriogenology 2018 Nov 22;126:95-105. Epub 2018 Nov 22.

Department of Veterinary Science, University of Torino, Largo Braccini 2/4, 10095, Grugliasco, TO, Italy.

The aim of this study was to collect and analyze ultrasound measurements of fetal-maternal structures during normal and pathological pregnancies in jennies, a livestock species of growing interest. For two breeding seasons, 38 jennies of different breeds and crossbreeds aged between 3 and 18 years were monitored weekly by transrectal examination using a portable Esaote ultrasound (MyLab™ 30 GOLD VET) with a 5-7.5 MHz probe. Read More

View Article
November 2018

Down-regulated expressed protein HMGB3 inhibits proliferation and migration, promotes apoptosis in the placentas of fetal growth restriction.

Int J Biochem Cell Biol 2018 Dec 10. Epub 2018 Dec 10.

Department of Obstetrics and Gynecology, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing, 210004, China. Electronic address:

Fetal growth restriction (FGR) is one of the major complications of pregnancy, which can lead to serious short-term and long-term diseases. High-mobility group box 3 (HMGB3) has been found to contribute to the development of many cancers. However, the role of HMGB3 in the pathogenesis of FGR is blank. Read More

View Article
December 2018

Adaptation of a skin sensitization assay to a chemically defined culture.

Toxicol In Vitro 2018 Dec 10. Epub 2018 Dec 10.

Department of Science and Technology, Science and Technology Institute, Federal University of São Paulo (UNIFESP), São José dos Campos, SP, Brazil; Rua Talim, 330, Vila Nair, São José dos Campos, SP CEP: 04021-001, Brazil.

There are currently three in vitro methods adopted by the Organization for the Economic Co-operation and Development for testing chemicals based on the third key event of the skin sensitization adverse outcome pathway, the activation of dendritic cells. All of them use culture medium supplemented with fetal bovine serum (FBS), which brings technical disadvantages and animal welfare concerns. The objective of this study was to analyze the possibility of eliminating the use of FBS in the human Cell Line Activation Test (h-CLAT). Read More

View Article
December 2018

Quantification of fetal steroids in nails of neonates to quantify prenatal stress and growth restriction.

Biol Psychol 2018 Dec 10. Epub 2018 Dec 10.

General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich-Heine-University, Moorenstraße 5, 40225, Düsseldorf, Germany. Electronic address:

This study assesses the impact of prenatal stress and intrauterine growth restriction (IUGR) on the dehydroepiandrosterone (DHEA) and dehydroepiandrosteronesulfate (DHEAS) concentrations in nails of newborns. Nail samples were gained from 56 newborn infants. The concentration of DHEA and DHEAS was measured by liquid chromatography/tandem mass spectrometry. Read More

View Article
December 2018

Clinical Opinion Letters Regarding Breastfeeding and Neonatal Abstinence Syndrome for Child Apprehension Family Court Proceedings.

J Hum Lact 2018 Dec 13:890334418818421. Epub 2018 Dec 13.

1 Dalhousie University School of Nursing, Halifax, NS, Canada.

The accelerating reach of opioid use disorder in North America includes increasing prevalence among pregnant people. In Canada, the rate of Neonatal Abstinence Syndrome (NAS) rose 27% between 2012-2013 and 2016-2017, and it is estimated that 0.51% of all infants now experience NAS after delivery. Read More

View Article
December 2018

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

PLoS Genet 2018 Dec 13;14(12):e1007845. Epub 2018 Dec 13.

Institute of Molecular Biology and Medicine, Laboratory Biology of the Cell Nucleus, Université Libre de Bruxelles (ULB), Gosselies, Belgium.

Nucleoporins build the nuclear pore complex (NPC), which, as sole gate for nuclear-cytoplasmic exchange, is of outmost importance for normal cell function. Defects in the process of nucleocytoplasmic transport or in its machinery have been frequently described in human diseases, such as cancer and neurodegenerative disorders, but only in a few cases of developmental disorders. Here we report biallelic mutations in the nucleoporin NUP88 as a novel cause of lethal fetal akinesia deformation sequence (FADS) in two families. Read More

View Article
December 2018

Lack of mutagenicity, genotoxicity and developmental toxicity in safety assessment tests of Lactobacillus mali APS1.

PLoS One 2018 13;13(12):e0208881. Epub 2018 Dec 13.

Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.

Lactobacillus (L.) mali APS1 isolated from sugary kefir grains has been proven to affect energy and glucose homeostasis. However, without proper safety assessment it cannot be recommended as probiotics for human consumption. Read More

View Article
December 2018

Recognizing Congenital Pressure Injuries: A Case Series.

Authors:
Deanna E Johnson

J Wound Ostomy Continence Nurs 2018 Dec 10. Epub 2018 Dec 10.

Deanna E. Johnson, MA, APRN, NNP-BC, CWON, Children's Hospital and Clinics, Minneapolis, Minnesota.

Background: Soft tissue injuries recognized at birth are a common occurrence and well described in the medical literature. Despite this, there has been no discussion of congenital pressure injuries. In this Clinical Challenges article, I describe 3 cases in which congenital skin injuries have occurred, all of which meet the National Pressure Ulcer Advisory Panel definition for a pressure injury and are demonstrably not the result of other etiologies. Read More

View Article
December 2018

Horner's Syndrome and Upper Extremity Weakness After Quadratus Lumborum Block for Postcesarean Section Analgesia: A Case Report.

A A Pract 2018 Dec 11. Epub 2018 Dec 11.

Boston University School of Medicine, Boston, Massachusetts.

A healthy, 34-year-old primigravida at 41 weeks gestational age presented for cesarean delivery due to a category 2 fetal heart tracing remote from delivery. After completion of the surgery under epidural anesthesia, bilateral quadratus lumborum blocks were performed for postoperative pain. Approximately 4 hours later, the patient developed left-sided arm weakness, left miosis, and ptosis. Read More

View Article
December 2018

A Biomimetic Nanodecoy Traps Zika Virus to Prevent Viral Infection and Fetal Microcephaly Development.

Nano Lett 2018 Dec 13. Epub 2018 Dec 13.

Zika virus (ZIKV) has emerged as a global health threat due to its unexpected causal link to devastating neurological disorders such as fetal microcephaly. However, to date, no approved vaccine or specific treatment is available for ZIKV infection. Here, we develop a biomimetic nanodecoy (ND) that can trap ZIKV, divert ZIKV away from its intended targets, and inhibit ZIKV infection. Read More

View Article
December 2018

Intrauterine Inflammation Damages Placental Angiogenesis via Wnt5a-Flt1 Activation.

Inflammation 2018 Dec 12. Epub 2018 Dec 12.

Department of Neonatology, Guangdong Women and Children Hospital, Guang Zhou Medical University, Guangzhou, 510010, Guangdong, China.

Intrauterine inflammation is the main reason for neonatal adverse outcomes and normal placenta perfusion plays an important role in fetal development. However, whether inflammation will affect placental angiogenesis and the underlying mechanism are still poorly understood. To investigate lipopolysaccharide (LPS)-induced intrauterine inflammation on placenta angiogenesis and Wnt5a-Flt1 expression. Read More

View Article
December 2018

The Origin of a New Progenitor Stem Cell Group in Human Development.

Adv Anat Embryol Cell Biol 2019 ;230:1-70

Department of Cellular and Molecular Medicine, University of Copenhagen, København N, Denmark.

The observation of two precursor groups of the early stem cells (Groups I and II) leads to the realization that a first amount of fetal stem cells (Group I) migrate from the AMG (Aortal-Mesonephric-Gonadal)-region into the aorta and its branching vessels. A second group (Group II) gains quite a new significance during human development. This group presents a specific developmental step which is found only in the human. Read More

View Article
January 2019

Trends in the Mode of Delivery of Pregnant Women in Rural Guatemala from a Quality Improvement Database.

Matern Child Health J 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.

Purpose To evaluate trends and factors associated with mode of delivery in the rural Southwest Trifinio region of Guatemala. Description We conducted a retrospective analysis of self-reported antepartum factors and postpartum outcomes recorded in a quality improvement database among 430 women enrolled in a home-based maternal healthcare program between June 1, 2015 and August 1, 2017. Assessment Over the study period, the rates of cesarean delivery (CD) increased (from 30 to 45%) and rates of vaginal delivery (VD) decreased (70-55%) while facility-based delivery attendance remained stable around 70%. Read More

View Article
December 2018

Morphometric study of the primary ossification center of the fibular shaft in the human fetus.

Surg Radiol Anat 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology and Oncology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Toruń, Poland.

Purposes: Precise morphometric data on the development of ossification centers in human fetuses may be useful in the early detection of skeletal dysplasias associated with delayed ossification center development and mineralization. The present study was performed to quantitatively examine the primary ossification center of the fibular shaft with respect to its linear, planar and volumetric parameters.

Materials And Methods: Using methods of CT, digital-image analysis (Osirix 3. Read More

View Article
December 2018

Intrauterine fetal MR versus postmortem MR imaging after therapeutic termination of pregnancy: evaluation of the concordance in the detection of brain abnormalities at early gestational stage.

Eur Radiol 2018 Dec 12. Epub 2018 Dec 12.

Pediatric Radiology and Neuroradiology Department, Children's Hospital V. Buzzi - ASST Fatebenefratelli-Sacco, Via Castelvetro 32, 20154, Milan, Italy.

Background And Purpose: Fetal postmortem MR Imaging (pmMRI) has been recently used as an adjuvant tool to conventional brain autopsy after termination of pregnancy (TOP). Our purpose was to compare the diagnostic performance of intrauterine MRI (iuMRI) and pmMRI in the detection of brain anomalies in fetuses at early gestational age (GA).

Material And Methods: We retrospectively collected 53 fetuses who had undergone iuMRI and pmMRI for suspected brain anomalies. Read More

View Article
December 2018

An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B in rats and rabbits.

Toxicol Res (Camb) 2018 Nov 28;7(6):1225-1235. Epub 2018 Aug 28.

School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , China . Email: ; Email:

(a herbal product) has long been used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Ginkgolide B is one of the important pharmacologically active components of . Dimethylaminoethyl ginkgolide B (a novel ginkgolide B derivative) has been developed to overcome the poor water-solubility of natural drugs and to achieve higher bioavailability. Read More

View Article
November 2018

Role of serum vitamin A and E in pregnancy.

Exp Ther Med 2018 Dec 5;16(6):5185-5189. Epub 2018 Oct 5.

Haidian Maternal and Child Health Hospital, Beijing 100080, P.R. China.

Serum levels of vitamin A and E in early, middle and late pregnancy were analyzed to evaluate vitamin nutritional status in pregnancy, and provide guidance for pregnant women about vitamin supplements in pregnancy. In total, 28,023 serum samples were randomly selected from pregnant women in early, middle and late pregnancy between January 2013 and June 2014 in Beijing. High performance liquid chromatography (HPLC) method was used to determine the concentration of serum vitamin A and E in pregnancy. Read More

View Article
December 2018

Factors influencing referrals for ultrasound-diagnosed complications during prenatal care in five low and middle income countries.

Reprod Health 2018 Dec 12;15(1):204. Epub 2018 Dec 12.

RTI International, Research Triangle Park, NC, USA.

Background: Ultrasound during antenatal care (ANC) is proposed as a strategy for increasing hospital deliveries for complicated pregnancies and improving maternal, fetal, and neonatal outcomes. The First Look study was a cluster-randomized trial conducted in the Democratic Republic of Congo, Guatemala, Kenya, Pakistan and Zambia to evaluate the impact of ANC-ultrasound on these outcomes. An additional survey was conducted to identify factors influencing women with complicated pregnancies to attend referrals for additional care. Read More

View Article
December 2018

Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study.

BMC Pregnancy Childbirth 2018 Dec 12;18(1):488. Epub 2018 Dec 12.

The University of North Carolina at Chapel Hill School of Medicine, Campus Box 7516, Chapel Hill, NC, 27599-7516, USA.

Background: Annually in the US, over 100,000 pregnant women with overt type 2 diabetes give birth. Strict maternal glycemic control is the key to optimizing infant outcomes. Medical treatment of type 2 diabetes in pregnancy is generally restricted to insulin, as data on the safety and efficacy of oral hypoglycemic agents in pregnancy are limited. Read More

View Article
December 2018

Cytokine Changes in Maternal Peripheral Blood Correlate With Time-to-Delivery in Pregnancies Complicated by Premature Prelabor Rupture of the Membranes.

Reprod Sci 2018 Dec 12:1933719118815590. Epub 2018 Dec 12.

2 Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada.

Premature prelabor rupture of the membranes (PPROM) causes one-third of preterm births worldwide and is most likely caused by subclinical intrauterine infection and/or inflammation. We proposed that women with systemic inflammation at the time of PPROM would have shorter latency. Peripheral blood samples were collected from 20 singleton pregnant women with PPROM between 23 ± 1 and 33 ± 6 weeks. Read More

View Article
December 2018

Use and experiences with external fetal monitoring devices among obstetrical providers.

J Matern Fetal Neonatal Med 2018 Dec 12:1-6. Epub 2018 Dec 12.

a Department of Obstetrics and Gynecology , The Ohio State University College of Medicine , Columbus , OH , USA.

Introduction: Fetal heart rate monitoring presents one of the few available methods for evaluating the fetus prior to birth. However, current devices on the market have significant shortcomings. We sought to describe the use and experiences with external fetal monitoring (EFM) devices among obstetrical providers. Read More

View Article
December 2018

Acceptability of Intrapartum Ultrasound Monitoring - Experience from a Romanian Longitudinal Study.

Curr Health Sci J 2015 Oct-Dec;41(4):355-360. Epub 2015 Dec 22.

Department of Obstetrics and Gynecology, Prenatal Diagnostic Unit, University of Medicine and Pharmacy of Craiova, University Emergency County Hospital Craiova, Romania.

Objectives: To assess the acceptability of intrapartum ultrasound (IPUS) labor monitoring in unselected Romanian women attending a tertiary maternity unit and the patients' experience of the examination (i.e. the perceived difficulty regarding the evaluation protocol). Read More

View Article
December 2015