27,340 results match your criteria Fetal Growth Restriction

Evaluation of placental oxygenation in fetal growth restriction using blood oxygen level-dependent magnetic resonance imaging.

Placenta 2022 Jun 18;126:40-45. Epub 2022 Jun 18.

Department of Obstetrics and Gynecology, Mie University Faculty Medicine, Mie, Japan.

Introduction: Abnormalities in placental function can lead to fetal growth restriction (FGR), but there is no consensus on their evaluation. Using blood oxygen level-dependent magnetic resonance imaging (BOLD MRI), we compared placental oxygenation between FGR cases and previously reported normal pregnancies.

Methods: Eight singleton pregnant women (>32 weeks of gestation) diagnosed with fetal growth failure during pregnancy were recruited. Read More

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Severe smallness as predictor of adverse neonatal outcome in suspected late SGA fetuses: systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2022 Jun 24. Epub 2022 Jun 24.

Fetal Medicine Research Center, BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Universitat de Barcelona, Barcelona, Catalonia, Spain.

Objective: To investigate the performance of severe smallness (estimated fetal weight [EFW] <3rd percentile) among suspected small-for-gestational-age (SGA) fetuses for the prediction of adverse perinatal outcomes.

Methods: A systematic search was launched to identify relevant studies held by the most relevant electronic databases. Random-effects modelling served to generate hierarchical summary receiver-operating characteristic curves (HSROCs). Read More

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Preeclampsia-induced alterations in brain and liver gene expression and DNA methylation patterns in fetal mice.

J Dev Orig Health Dis 2022 Jun 24:1-6. Epub 2022 Jun 24.

Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Exposure to pregnancy complications, including preeclampsia (PE), has lifelong influences on offspring's health. We have previously reported that experimental PE, induced in mice by administration of adenoviral sFlt1 at gestational day 8.5 combined with LPS at day 10. Read More

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Machine Learning Model for Classifying the Results of Fetal Cardiotocography Conducted in High-Risk Pregnancies.

Yonsei Med J 2022 Jul;63(7):692-700

Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Fetal well-being is usually assessed via fetal heart rate (FHR) monitoring during the antepartum period. However, the interpretation of FHR is a complex and subjective process with low reliability. This study developed a machine learning model that can classify fetal cardiotocography results as normal or abnormal. Read More

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The Effect of Von Willebrand Disease on Pregnancy, Delivery, and Postpartum Period: A Retrospective Observational Study.

Medicina (Kaunas) 2022 Jun 7;58(6). Epub 2022 Jun 7.

Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia.

Several reports indicate that women with von Willebrand disease (VWD) are at an increased risk of bleeding and other complications during pregnancy and childbirth. The aim of this study was to investigate the effect of VWD on the course of pregnancy, childbirth, and the postpartum period. This was a retrospective study that compared many variables between women with VWD ( = 26) and women without VWD ( = 297,111) who gave birth between 2002 and 2016 in Slovenia. Read More

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Umbilical Cord Knots: Is the Number Related to Fetal Risk?

Medicina (Kaunas) 2022 May 25;58(6). Epub 2022 May 25.

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34137 Trieste, Italy.

True knots of the umbilical cord (UC) are a rare occurrence and are reported in 0.4-1.2% of deliveries. Read More

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The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review.

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

Department of Obstetrics and Perinatology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.

Kisspeptins are the family of neuropeptide products of the gene that exert the biological action by binding with the G-protein coupled receptor 54 (GPR54), also known as the KISS-1 receptor. The kisspeptin level dramatically increases during pregnancy, and the placenta is supposed to be its primary source. The role of kisspeptin has already been widely studied in hypogonadotropic hypogonadism, fertility, puberty disorders, and insulin resistance-related conditions, including type 2 diabetes mellitus, polycystic ovary syndrome, and obesity. Read More

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Placental Syndromes-A New Paradigm in Perinatology.

Int J Environ Res Public Health 2022 Jun 16;19(12). Epub 2022 Jun 16.

2nd Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 01-809 Warsaw, Poland.

Placental syndromes include pregnancy loss, fetal growth restriction, preeclampsia, preterm delivery, premature rupture of membranes, placental abruption and intrauterine fetal demise. This paper discusses the common etiopathogenesis of those syndromes and the role of angiogenic biomarkers in their development. Pregnancy implantation, placental development and maternal adaptation are complex processes in which fetal and maternal cells interact. Read More

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Maternal HPV Infection and the Estimated Risks for Adverse Pregnancy Outcomes-A Systematic Review.

Diagnostics (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Obstetrics and Gynecology Clinic, Department of Obstetrics and Gynecology, Faculty of General Medicine, Elias University Hospital, Carol Davila University of Medicine and Pharmacy, 011461 Bucharest, Romania.

Background: Human Papilloma Virus (HPV) represents the most prevalent genital infection in young women of reproductive age.

Objective: This systematic review aims to estimate the effect of HPV infection during pregnancy and assess the correlation between HPV and adverse pregnancy outcomes.

Materials And Methods: The search strategy has been developed based on the PICOS framework: Population (pregnant women infected with HPV), Intervention (HPV infection confirmed by molecular tests), Comparator (pregnant women without HPV infection), Outcomes (adverse pregnancy outcomes) and Study design (observational studies). Read More

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Altered Transmission of Cardiac Cycles to Ductus Venosus Blood Flow in Fetal Growth Restriction: Why Ductus Venosus Reflects Fetal Circulatory Changes More Precisely.

Diagnostics (Basel) 2022 Jun 4;12(6). Epub 2022 Jun 4.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi Abeno-ku Osaka, Osaka 545-8585, Japan.

We aimed to investigate the relation between the time intervals of the flow velocity waveform of ductus venosus (DV-FVW) and cardiac cycles. We defined Delta A as the difference in the time measurements between DV-FVW and cardiac cycles on the assumption that the second peak of ductus venosus (D-wave) starts simultaneously with the opening of the mitral valve (MV). As well, we defined Delta B as the difference of the time measurements between DV-FVW and cardiac cycles on the assumption that the D-wave starts simultaneously with the closure of the aortic valve (AV). Read More

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A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism.

Biomedicines 2022 Jun 15;10(6). Epub 2022 Jun 15.

Unité Mixte de Recherche (UMR) MITOVASC, Structure Fédérative de Recherche (SFR) ICAT, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers, F-49000 Angers, France.

(1) Background: Intrauterine growth restriction (IUGR) involves metabolic changes that may be responsible for an increased risk of metabolic and cardiovascular diseases in adulthood. Several metabolomic profiles have been reported in maternal blood and urine, amniotic fluid, cord blood and newborn urine, but the placenta has been poorly studied so far. (2) Methods: To decipher the origin of this metabolic reprogramming, we conducted a targeted metabolomics study replicated in two cohorts of placenta and one cohort of cord blood by measuring 188 metabolites by mass spectrometry. Read More

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Comparative Characteristics of Sialoglycans Expression Disorders in the Placental Barrier Structures in Preeclampsia and Fetal Growth Restriction.

Bull Exp Biol Med 2022 Jun 24. Epub 2022 Jun 24.

V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

We compared the expression profiles of α2,3- and α2,6-sialoglycans in the glycocalyx of the placental barrier structures in early and late forms of preeclampsia and fetal growth restriction using the method of lectin histochemistry. It was found that the expression of α2,3-sialoglycans in the syncytiotrophoblast and fetal endothelium of the terminal villi of the placenta was reduced in preeclampsia in comparison with normal placenta and, on the contrary, was increased in fetal growth restriction. Significant differences were found in both clinical phenotypes of preeclampsia and fetal growth restriction. Read More

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Acta Clin Croat 2021 Dec;60(4):651-656

Institute of Neonatology, Belgrade, Serbia.

Germinal matrix-intraventricular brain hemorrhage is mostly found in preterm neonates, but may also occur in term neonates. The aim of this study was to analyze the prevalence and severity of this type of hemorrhage in moderate and late preterm and early term neonates with intrauterine growth restriction. In the prospective analysis, 100 newborns were examined, i. Read More

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December 2021

Efficacy of Pulsatility Index of Fetal Vessels in Predicting Adverse Perinatal Outcomes in Fetuses with Growth Restriction - Differences in Early- and Late-Onset Fetal Growth Restriction.

Maedica (Bucur) 2022 Mar;17(1):107-115

Nice Hospitals, Hyderabad, India.

Doppler ultrasound of fetal vessels plays an important role in diagnosing fetal growth restriction (FGR). It also aids in early detection of fetal compromise and clinical decision making. To determine the efficacy of the pulsatility index (PI) of the fetal umbilical artery (UA) and middle cerebral artery (MCA) in the third trimester of pregnancy for predicting adverse perinatal outcomes in the growth restricted fetuses. Read More

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Machine learning methods to predict attrition in a population-based cohort of very preterm infants.

Sci Rep 2022 Jun 22;12(1):10587. Epub 2022 Jun 22.

Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.

The timely identification of cohort participants at higher risk for attrition is important to earlier interventions and efficient use of research resources. Machine learning may have advantages over the conventional approaches to improve discrimination by analysing complex interactions among predictors. We developed predictive models of attrition applying a conventional regression model and different machine learning methods. Read More

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Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN cluster randomised trial.

PLoS Med 2022 Jun 21;19(6):e1004004. Epub 2022 Jun 21.

Department of Women and Children's Health, King's College London, London, United Kingdom.

Background: Antenatal detection and management of small for gestational age (SGA) is a strategy to reduce stillbirth. Large observational studies provide conflicting results on the effect of the Growth Assessment Protocol (GAP) in relation to detection of SGA and reduction of stillbirth; to the best of our knowledge, there are no reported randomised control trials. Our aim was to determine if GAP improves antenatal detection of SGA compared to standard care. Read More

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Detecting fetal growth restriction with customised assessment: Is the jury still out?

PLoS Med 2022 Jun 21;19(6):e1004028. Epub 2022 Jun 21.

Maternal & Fetal Health Research Centre, Division of Developmental Biology & Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

In this Perspective, Kate Duhig and Jenny Myers discuss strategies to improve the detection of abnormal fetal growth trajectories in the antenatal period. Read More

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Effects of Ponderal Index on Neonatal Mortality and Morbidities in Extremely Premature Infants.

J Korean Med Sci 2022 Jun 20;37(24):e198. Epub 2022 Jun 20.

Department of Pediatrics, Hanyang University Guri Hospital, Guri, Korea.

Background: To evaluate how intrauterine stress affects extremely premature infants in terms of intrauterine growth restriction. We hypothesized that extremely premature infants with mildly-low ponderal index (MPI) would have better neonatal outcomes.

Methods: We selected 2,721 subjects of 23 to 28 weeks of gestation between 2013 and 2015 from Korean Neonatal Network database. Read More

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Worth the paper it's written on? A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK.

Int J Epidemiol 2022 Jun 20. Epub 2022 Jun 20.

United Kingdom Audit and Research Collaborative in Obstetrics and Gynaecology, UK.

Background: The Medical Certificate of Stillbirth (MCS) records data about a baby's death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies.

Methods: A multicentre evaluation was conducted, examining MCS issued 1 January 2018 to 31 December 2018 in 76 UK obstetric units. Read More

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Effect of porcine reproductive and respiratory syndrome virus 2 on angiogenesis and cell proliferation at the maternal-fetal interface.

Vet Pathol 2022 Jun 20:3009858221105053. Epub 2022 Jun 20.

University of Saskatchewan, Saskatoon, SK, Canada.

Angiogenesis and cell proliferation in reproductive tissues are essential events for the maintenance of pregnancy, and alterations can lead to compromised fetal development and survival. Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) induces reproductive disease with negative financial and production impact on the swine industry. PRRSV-2 infection alters placental physiology through inflammatory and apoptotic pathways, yet fetal susceptibility varies. Read More

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Reducing Perinatal Mortality in India: Two-Years Results of the IRIA Fetal Radiology Samrakshan Program.

Indian J Radiol Imaging 2022 Mar 19;32(1):30-37. Epub 2022 Apr 19.

Department of Radiodiagnosis, Sampurna Sodani Diagnostic Clinic, Indore, Madhya Pradesh, India.

 The aim of the study is to determine improvements in perinatal mortality at the end of the first 2 years from the initiation of the Samrakshan program of the Indian Radiological and Imaging Association.  Samrakshan is a screening program of pregnant women that uses trimester-specific risk assessment protocols including maternal demographics, mean arterial pressure, and fetal Doppler studies to classify women as high risk or low risk for preterm preeclampsia (PE) and fetal growth restriction (FGR). Low dose aspirin 150 mg daily once at bedtime was started for pregnant women identified as high risk in the 11-13 weeks screening. Read More

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Outcomes With Levothyroxine Treatment in Early Pregnancy With Subclinical Hypothyroidism.

Cureus 2022 May 14;14(5):e24984. Epub 2022 May 14.

Department of Medicine, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, IND.

Introduction Adverse pregnancy outcomes in women with subclinical hypothyroidism (SCH) are well documented, whereas data regarding the risk and benefit of levothyroxine treatment in such cases are insufficient and inconsistent. Our study aimed to evaluate the effects of levothyroxine treatment on pregnancy outcomes in these women. Materials and methods Healthy women with a singleton pregnancy were screened before 12 weeks of gestation for subclinical hypothyroidism using 2017 American Thyroid Association guidelines. Read More

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Placental pathology in sudden intrauterine death (SIUD) in SARS-CoV-2-positive oligosymptomatic women.

Arch Gynecol Obstet 2022 Jun 18. Epub 2022 Jun 18.

Division of Breast Gynecologic and Perinatal Pathology, Institute of Pathology, University Hospital of Leipzig, Liebigstrasse 26, 04103, Leipzig, Germany.

Background: Pregnant women are also susceptible to SARS-CoV-2. Although an infection of the placenta may be rare, pregnancy may occasionally be affected by intrauterine failure. The knowledge of placental morphology on sudden intrauterine demise is still limited. Read More

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Prenatal detection of pure proximal 6q14.1 microduplication encompassing LCA5 gene: A variant of likely benign.

Medicine (Baltimore) 2022 Jun 17;101(24):e29369. Epub 2022 Jun 17.

Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China.

Abstract: Trisomy 6q is a recognizable syndrome which exhibits psychomotor/growth retardation, developmental/intellectual disabilities, feeding difficulties, facial dysmorphism, hearing loss, brain and heart malformations. The purpose of this study was to delineate the prenatal features of proximal 6q14.1 duplication in fetal period, which was rarely reported in clinic. Read More

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Risk Stratification for Pregnancies Diagnosed With Fetal Growth Restriction Based on Placental MRI.

J Magn Reson Imaging 2022 Jun 17. Epub 2022 Jun 17.

Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Diagnosis of fetal growth restriction (FGR) entails difficulties with differentiating fetuses not fulfilling their growth potential because of pathologic conditions, such as placental insufficiency, from constitutionally small fetuses. The feasibility of placental MRI for risk stratification among pregnancies diagnosed with FGR remains unexplored.

Purpose: To explore quantitative MRI features useful to identify pregnancies with unfavorable outcomes and to assess the diagnostic performance of visual analysis of MRI to detect pregnancies with unfavorable outcomes, among pregnancies diagnosed with FGR. Read More

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High miR-200a-3p expression has high diagnostic values for hypertensive disorders complicating pregnancy and predicts adverse pregnancy outcomes.

Xin He Danni Ding

BMC Pregnancy Childbirth 2022 Jun 15;22(1):490. Epub 2022 Jun 15.

Department of Obstetrics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, 61 Jiefang West Road, Changsha, 410005, Hunan, China.

Background: Hypertensive disorders complicating pregnancy (HDCP) are various heterogeneous conditions. microRNA (miR)-200a-3p is involved in HDCP diagnosis. This study explored the effects of miR-200a-3p on HDCP patients. Read More

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Perinatal outcomes in twin late preterm pregnancies: results from an Italian area-based, prospective cohort study.

Ital J Pediatr 2022 Jun 16;48(1):101. Epub 2022 Jun 16.

Obstetrics and Gynecology Unit, Mother-Infant and Adult Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41125, Modena, Italy.

Background: Multiple gestations represent a considerable proportion of pregnancies delivering in the late preterm (LP) period. Only 30% of LP twins are due to spontaneous preterm labor and 70% are medically indicated; among this literature described that 16-50% of indicated LP twin deliveries are non-evidence based. As non-evidence-based delivery indications account for iatrogenic morbidity that could be prevented, the objective of our observational study is to investigate first neonatal outcomes of LP twin pregnancies according to gestational age at delivery, chorionicity and delivery indication, then non evidence-based delivery indications. Read More

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Gestational weight gain during the second and third trimesters and adverse pregnancy outcomes, results from a prospective pregnancy cohort in urban Tanzania.

Reprod Health 2022 Jun 16;19(1):140. Epub 2022 Jun 16.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.

Background: Appropriate gestational weight gain (GWG) is important for optimal pregnancy outcomes. This study prospectively evaluated the associations between GWG during the second and third trimesters of pregnancy and adverse pregnancy outcomes in an urban Tanzanian pregnancy cohort.

Methods: We used data from a randomized clinical trial conducted among pregnant women recruited by 27 weeks of gestation in Dar es Salaam, Tanzania (N = 1230). Read More

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Impact of a hybrid model of prenatal care on the diagnosis of fetal growth restriction.

Am J Perinatol 2022 Jun 16. Epub 2022 Jun 16.

Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, United States.

Objective: Fetal growth restriction (FGR) is associated with poor neonatal outcomes and stillbirth, and screening via fundal height or ultrasound is routinely performed. During the COVID-19 pandemic, we developed a hybrid model of prenatal care which decreased the frequency of in-person visits and incorporated telemedicine visits. We sought to determine if prenatal FGR diagnoses decreased with this hybrid model compared to routine prenatal care. Read More

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Detection of small- and large-for-gestational age using different combinations of prenatal and postnatal charts.

Ultrasound Obstet Gynecol 2022 Jun 16. Epub 2022 Jun 16.

Fetal Medicine Unit, John Radcliffe Hospital, Oxford, UK.

Objective: To determine the extent to which the detection rate of small for gestational age (SGA) and large for gestational age (LGA) are influenced by the combination of different estimated fetal weight (EFW) and birthweight (BW) charts.

Methods: Cohort study of all pregnant women with a singleton term birth in a university hospital during a 3-year period. All participants had a universal 36 week ultrasound scan for EFW measurement; and BW was recorded at delivery. Read More

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