23,457 results match your criteria Fetal Growth Restriction


CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34 + cell presence, and autophagy in the endometrium.

Biol Reprod 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA.

Placenta development is characterized by extensive angiogenesis and vascularization but if these processes are compromised placental dysfunction occurs, which is the underlying cause of pregnancy complications such as preeclampsia and intrauterine growth restriction. Dysregulation of placental angiogenesis has emerged as one of the main pathophysiological features in the development of placental insufficiency and its clinical consequences. The signaling axis initiated by chemokine ligand 12 (CXCL12) and its receptor CXCR4 stimulate angiogenesis in other tissues, and may be central to placental vascularization. Read More

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http://dx.doi.org/10.1093/biolre/ioz073DOI Listing

SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats.

PLoS One 2019 19;14(4):e0215611. Epub 2019 Apr 19.

Department of Physiology & Pharmacology, The University of Western Ontario, London, Ontario, Canada.

Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215611PLOS

Memory T Cells in Pregnancy.

Front Immunol 2019 2;10:625. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Adaptations of the maternal immune response are necessary for pregnancy success. Insufficient immune adaption is associated with pregnancy pathologies such as infertility, recurrent miscarriage, fetal growth restriction, spontaneous preterm birth, and preeclampsia. The maternal immune system is continuously exposed to paternal-fetal antigens; through semen exposure from before pregnancy, through fetal cell exposure in pregnancy, and through microchimerism after pregnancy. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00625
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http://dx.doi.org/10.3389/fimmu.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455355PMC
April 2019
1 Read

Evaluation of Placental Perfusion Based on Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Its Predictive Value for Late-Onset Fetal Growth Restriction.

Geburtshilfe Frauenheilkd 2019 Apr 12;79(4):396-401. Epub 2018 Dec 12.

Department of Medical Image, Guangzhou Women and Children's Medical Center, Guangzhou, China.

The aim of this study was to investigate placental blood perfusion in middle and late pregnancy and explore its predictive value for fetal growth restriction (FGR). All pregnant women included in the study were examined using placental intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Three IVIM parameters (D, f, D*) were obtained for each pregnant woman and analyzed using Image J software. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0717-5275
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http://dx.doi.org/10.1055/a-0717-5275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461467PMC
April 2019
1 Read

Massive subchorionic hematoma (Breus' mole) presents a variety of ultrasonic appearances: A case report and literature review.

Clin Case Rep 2019 Apr 5;7(4):744-748. Epub 2019 Mar 5.

Department of Obstetrics and Gynecology Yokohama City University Hospital Yokohama Japan.

Massive subchorionic hematoma (MSH) presents a variety of ultrasonic appearances. Placentomegaly with fetal growth restriction should be included as one of the differential diagnoses for intraplacental MSH. Care management of MSH requires to be tailored to each individual's responses while taking the NICU's capabilities and the patient's wishes into consideration. Read More

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http://dx.doi.org/10.1002/ccr3.2036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452457PMC

miRNA-210-3p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Fetal Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Selective intrauterine growth restriction (sIUGR), which affects approximately 10%-15% of monochorionic (MC) twin pregnancies, is highly associated with intrauterine foetal death and neurological impairment in both twins. Data suggest that unequal sharing of the single placenta is the main contributor to birth weight discordance. While MC twins and their placenta derive from a single zygote and harbour almost identical genetic material, the underlying mechanisms of phenotypic discrepancies in MC twins remain unclear. Read More

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http://dx.doi.org/10.1111/jcmm.14335DOI Listing
April 2019
1 Read

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.

Front Endocrinol (Lausanne) 2019 29;10:188. Epub 2019 Mar 29.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

Intrauterine growth restriction (IUGR) is a complex global healthcare issue. Concerted research and clinical efforts have improved our knowledge of the neurodevelopmental sequelae of IUGR which has raised the profile of this complex problem. Nevertheless, there is still a lack of therapies to prevent the substantial rates of fetal demise or the constellation of permanent neurological deficits that arise from IUGR. Read More

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http://dx.doi.org/10.3389/fendo.2019.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449431PMC

School Age Neurological and Cognitive Outcomes of Fetal Growth Retardation or Small for Gestational Age Birth Weight.

Front Endocrinol (Lausanne) 2019 28;10:186. Epub 2019 Mar 28.

School of Psychology, University of East London, London, United Kingdom.

Children who were growth restricted (FGR) and are born small for gestational age (SGA) may experience poorer long term neurological and cognitive outcomes. Those also born preterm may have particular difficulties. The objective of this paper was to review the literature on school age neurocognitive outcome for term and preterm children that was published in the last 15 years. Read More

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http://dx.doi.org/10.3389/fendo.2019.00186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447606PMC
March 2019
1 Read

Fetal growth restriction is associated with an altered cardiopulmonary and cerebral hemodynamic response to surfactant therapy in preterm lambs.

Pediatr Res 2019 Apr 14. Epub 2019 Apr 14.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.

Background: Efficacy of surfactant therapy in fetal growth restricted (FGR) preterm neonates is unknown.

Methods: Twin-bearing ewes underwent surgery at 105 days gestation to induce FGR in one twin by single umbilical artery ligation. At 123-127 days, catheters and flow probes were implanted in pulmonary and carotid arteries to measure flow and pressure. Read More

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http://dx.doi.org/10.1038/s41390-019-0398-4DOI Listing

Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity.

Mol Cell Endocrinol 2019 Apr 11. Epub 2019 Apr 11.

Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.

In the human placenta, extravillous trophoblasts (EVTs) invade maternal decidual tissues (interstitial trophoblasts) and maternal spiral arteries (endovascular trophoblasts). Although endovascular trophoblasts are directly exposed to maternal blood containing complement components, they are not eliminated by complement-dependent cytotoxicity (CDC). In this study, we investigated the expression and possible function of CD59, one of the membrane-bound complement regulators, in EVTs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03037207193010
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http://dx.doi.org/10.1016/j.mce.2019.04.006DOI Listing
April 2019
2 Reads

Pathogenic roles of anti-C1q antibodies in recurrent pregnancy loss.

Clin Immunol 2019 Apr 8;203:37-44. Epub 2019 Apr 8.

Department of Rheumatology, Endocrinology and Nephrology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan.

Recurrent pregnancy loss (RPL) is often considered idiopathic, however excessive complement activation has been observed in pregnancy related manifestations. Anti-C1q antibodies (anti-C1q) are associated with the activation of complement pathway in lupus patients, while it remains unclear in RPL. Firstly, we showed that both the prevalence and titre of anti-C1q were significantly higher in unexplained RPL than in healthy parous individuals. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.005DOI Listing
April 2019
2 Reads

Three consecutive pregnancies in a patient with chronic autoimmune thyroid disease associated with hypothyroidism and extremely high levels of anti-TSH receptor antibodies.

Thyroid 2019 Apr 11. Epub 2019 Apr 11.

Centre Hospitalier Universitaire de Reims, 26992, Service d'Endocrinologie - Diabète - Nutrition, Reims, Champagne-Ardenne, France.

Background: Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications.

Patient Findings: We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). Read More

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https://www.liebertpub.com/doi/10.1089/thy.2018.0098
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http://dx.doi.org/10.1089/thy.2018.0098DOI Listing
April 2019
3 Reads

Combined antenatal and postnatal steroid effects on fetal and postnatal growth, and neurological outcomes in neonatal rats.

Am J Transl Res 2019 15;11(3):1697-1710. Epub 2019 Mar 15.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of California, Irvine Medical Center Orange, CA, USA.

Preterm infants are often exposed to both antenatal and postnatal glucocorticoids (GCs). We tested the hypothesis that combined antenatal and postnatal GCs have long-lasting adverse effects on fetal and neonatal growth, growth factors, and neurological outcomes. Pregnant rats were administered a single IM dose of betamethasone (0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456541PMC
March 2019
1 Read

Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment.

Front Endocrinol (Lausanne) 2019 26;10:179. Epub 2019 Mar 26.

Division of Obstetrics and Gynecology, Department of Women-Children-Teenagers, University Hospitals Geneva, Geneva, Switzerland.

The environment in which a fetus develops is not only important for its growth and maturation but also for its long-term postnatal health and neurodevelopment. Several hormones including glucocorticosteroids, estrogens and progesterone, insulin growth factor and thyroid hormones, carefully regulate the growth of the fetus and its metabolism during pregnancy by controlling the supply of nutrients crossing the placenta. In addition to fetal synthesis, hormones regulating fetal growth are also expressed and regulated in the placenta, and they play a key role in the vulnerability of the developing brain and its maturation. Read More

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http://dx.doi.org/10.3389/fendo.2019.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443724PMC

A cohort study of the association between maternal serum Inhibin-A and adverse pregnancy outcomes: a population-based study.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):124. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Background: To compare the rates of adverse pregnancy outcomes between women with normal and abnormal inhibin-A levels.

Methods: Based on a prospective database of Down syndrome screening program, the consecutive records were comprehensively reviewed. Pregnancies were classified into three groups: normal, high (> 2 MoM) and low (< 0. Read More

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http://dx.doi.org/10.1186/s12884-019-2266-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458687PMC
April 2019
6 Reads

Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia.

Lupus 2019 Apr 10:961203319843343. Epub 2019 Apr 10.

1 Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Hydroxychloroquine (HCQ) is regarded as a mainstay in the treatment of systemic lupus erythematosus (SLE) because of its efficacy in preventing flares, achieving remission, and reducing overall mortality. However, the impact of HCQ on pregnancy outcomes remains controversial.

Objective: We aimed to investigate the effect of HCQ on pregnancy outcomes in patients with SLE. Read More

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http://dx.doi.org/10.1177/0961203319843343DOI Listing
April 2019
4 Reads

Feasibility of Postmortem Imaging Assessment of Brain: Liver Volume Ratios with Pathological Validation.

Fetal Diagn Ther 2019 Apr 10:1-8. Epub 2019 Apr 10.

Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Introduction: Organ volumes at postmortem magnetic resonance imaging (PMMR) should reflect autopsy organ weights, and thus brain:liver volume ratios on imaging could be a surrogate for weight volume ratios at autopsy to indicate fetal growth restriction (FGR). This study aims to determine whether imaging-based organ volume ratios can replace autopsy organ weight ratios. Materials and Meth ods: An unselected cohort of perinatal deaths underwent PMMR prior to autopsy. Read More

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http://dx.doi.org/10.1159/000497158DOI Listing
April 2019
2 Reads

Herbal Medicinal Product Use During Pregnancy and the Postnatal Period: A Systematic Review.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Institute of Applied Health Sciences, Aberdeen University, Aberdeen, Scotland, United Kingdom; School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, Scotland, UK, and College of Pharmacy, Qatar University, Doha, Qatar; and NHS Grampian, Foresterhill Health Campus, Aberdeen, Scotland, United Kingdom.

Objective: To report the incidence and nature of herbal medicinal products' adverse events and herb-drug interactions used by some pregnant and postnatal women.

Data Sources: The Allied and Complementary Medicine Database, the Cumulative Index to Nursing and Allied Health Literature, EMBASE, the Cochrane Library, MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov were searched from inception until August 2018. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003217DOI Listing
April 2019
1 Read

In utero sFlt-1 exposure differentially affects gene expression patterns in fetal liver.

J Dev Orig Health Dis 2019 Apr 10:1-9. Epub 2019 Apr 10.

1Department of Obstetrics and Gynecology,University of Groningen,University Medical Center Groningen,The Netherlands.

The soluble fms-like tyrosine kinase factor 1 (sFlt-1) is a major contributor to antiangiogenesis during preeclampsia. However, little is known about the effects of sFlt-1 on fetal health. In this study we aim to evaluate the effects of the sFlt-1 concentration during pregnancy on fetal liver physiology. Read More

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http://dx.doi.org/10.1017/S2040174418000831DOI Listing
April 2019
2 Reads

Preeclampsia link to gestational hypoxia.

Authors:
W Tong D A Giussani

J Dev Orig Health Dis 2019 Apr 10:1-12. Epub 2019 Apr 10.

1Department of Physiology Development & Neuroscience,University of Cambridge,Cambridge,UK.

Complications of pregnancy remain key drivers of morbidity and mortality, affecting the health of both the mother and her offspring in the short and long term. There is lack of detailed understanding of the pathways involved in the pathology and pathogenesis of compromised pregnancy, as well as a shortfall of effective prognostic, diagnostic and treatment options. In many complications of pregnancy, such as in preeclampsia, there is an increase in uteroplacental vascular resistance. Read More

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http://dx.doi.org/10.1017/S204017441900014XDOI Listing
April 2019
1 Read

Primary Thrombophilia in Mexico XIII: Localization of the Thrombotic Events in Mexican Mestizos With the Sticky Platelet Syndrome.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619841700

1 Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico.

The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both. The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. Read More

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http://dx.doi.org/10.1177/1076029619841700DOI Listing
April 2019
1 Read
1.575 Impact Factor

Rubella (German measles) revisited.

Hong Kong Med J 2019 Apr 10;25(2):134-141. Epub 2019 Apr 10.

Department of Pediatric Institute, Kuala Lumpur General Hospital, Malaysia.

Rubella is generally a mild and self-limited disease in children. During pregnancy, rubella can have potentially devastating effects on the developing fetus. Postnatal rubella is transmitted primarily by inhalation of virus-laden airborne droplets or direct contact with infected nasopharyngeal secretions. Read More

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http://dx.doi.org/10.12809/hkmj187785DOI Listing
April 2019
1 Read

Sildenafil therapy in early-onset fetal growth restriction: waiting for the individual patient data meta-analysis.

BJOG 2019 Apr 7. Epub 2019 Apr 7.

Hospital Clinic de Barcelona, Sabino de Arana 1 Barcelona, Barcelona, 08028, Spain.

The Sildenafil TheRapy In Dismal prognosis Early-onset intrauterine growth Restriction (STRIDER) Consortium was set up in 2011 to assess the effects of sildenafil for the treatment of fetal growth restriction (FGR). The project included 4 trials with different but related main outcomes. Once completed, it was planned an individual patient data (IPD) meta-analysis of the four trials to address with adequate statistical power the effects on hard perinatal outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1471-0528.15
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http://dx.doi.org/10.1111/1471-0528.15753DOI Listing
April 2019
7 Reads

An Analysis of Cause of Stillbirth in a Tertiary Care Hospital of Delhi: A Contribution to the WHO SEARO Project.

J Obstet Gynaecol India 2019 Apr 10;69(2):155-160. Epub 2018 Aug 10.

Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Shahid Bhagat Singh Marg, New Delhi, 110001 India.

Background: Over 98% of the world's total stillbirths are believed to occur in developing countries and still have received very little research, programmatic or policy attention.

Aims And Objective: To collect data on epidemiological profile of cases experiencing stillbirths, to assess the associated antenatal high risk factors present and to find out the probable cause of stillbirth.

Materials And Methods: This was a cross-sectional, observational study, which was done as part of WHO SEARO project after ethical clearance. Read More

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http://dx.doi.org/10.1007/s13224-018-1161-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430444PMC
April 2019
3 Reads

Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing.

Placenta 2019 Mar 12;78:44-53. Epub 2019 Mar 12.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Introduction: Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways.

Methods: Rats were fed a normal or HFD diet for 10 weeks before conception and during gestation. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.03.004DOI Listing
March 2019
1 Read

Fetal alcohol spectrum disorders - diagnostic difficulties in the neonatal period and new diagnostic approaches.

Dev Period Med 2019 ;23(1):60-66

Student of Medical University of Gdansk, Poland.

Fetal alcohol spectrum disorders (FASD) is a group of disorders that can occur in children whose mothers consumed alcohol in pregnancy. Diagnosis of fetal alcohol syndrome is based on the appearance of growth deficiency, the presence of the three key features of facial dysmorphism (short palpebral fissures, thin upper lip, smooth or flattend philtrum) and/or disorders in the central nervous system (minimum 3) and prenatal exposure to alcohol (confirmed if possible). Early diagnosis of fetal alcohol syndrome - after birth or in infancy - is very often impossible or very difficult due to the incomplete manifestation of the key dysmorphic features. Read More

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January 2019
5 Reads

Proportionality at birth and left ventricular hypertrophy in healthy adolescents.

Early Hum Dev 2019 Apr 3;132:24-29. Epub 2019 Apr 3.

Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA, USA; Vascular Biology Center, Augusta University, Augusta, GA, USA. Electronic address:

Background: Perinatal growth has important implications for cardiac development. Low birth weight is associated with cardiovascular (CV) events and mortality, and animal studies have shown that fetal growth restriction is associated with cardiac remodeling in the perinatal period leading to a permanent loss of cardiomyocyte endowment and compensatory hypertrophy.

Aims: To determine associations of birthweight (BW) and multiple proportionality indexes (body mass index (BMI); weight/length and Ponderal index (PI); weight/length) at birth on one hand, with left ventricular (LV) structure and function during adolescence. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.03.018DOI Listing
April 2019
3 Reads
1.931 Impact Factor

The effect of parity on longitudinal maternal hemodynamics.

Am J Obstet Gynecol 2019 Apr 2. Epub 2019 Apr 2.

Fetal Medicine Research Institute, King's College London. Electronic address:

Background: Parous women have a lower risk for pregnancy complications, such as preeclampsia (PE) or delivery of small for gestational age (SGA) neonates. However, parous women are a heterogeneous group of patients as they contain a low-risk cohort with previously uncomplicated pregnancies and a high-risk cohort with previous pregnancies complicated by PE and / or SGA. Previous studies examining the effect of parity on maternal hemodynamics, including cardiac output (CO) and peripheral vascular resistance (PVR), did not distinguish between parous women with and without a history of PE or SGA and reported contradictory results. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.027DOI Listing
April 2019
2 Reads

Is prenatal identification of small-for-gestational-age fetuses useful?

Ultrasound Obstet Gynecol 2019 Apr 4. Epub 2019 Apr 4.

AUDIPOG (Association des Utilisateurs de Dossiers informatisés en Pédiatrie, Obstétrique et Gynécologie), Faculty of Medicine RTH Laennec, 7 rue Guillaume Paradin, 69008, Lyon, France.

Objective: To assess whether prenatal identification of small-for-gestational-age (SGA) fetuses would reduce the rates of the primary composite outcome of 'stillbirths and neonatal complications', and secondary outcomes of stillbirth and low 5-min Apgar score.

Methods: This historical cohort study was conducted with women who had singleton delivery (≥ 32 weeks), in 247 French maternity units. Medical terminations of pregnancy, infants with malformations, and women with missing delivery data were excluded. Read More

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http://dx.doi.org/10.1002/uog.20282DOI Listing
April 2019
1 Read

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model.

Front Endocrinol (Lausanne) 2019 21;10:165. Epub 2019 Mar 21.

Department of Gynecology and Obstetrics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

The anti-angiogenic soluble fms-like tyrosine kinase 1 (sFLT1) is one of the candidates in the progression of preeclampsia, often associated with fetal growth restriction (FGR). Therapeutic agents against preeclampsia with/without FGR, as well as adequate transgenic sFLT1 mouse models for testing such agents, are still missing. Much is known about sFLT1-mediated endothelial dysfunction in several tissues; however, the influence of sFLT1 on placental and fetal development is currently unknown. Read More

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http://dx.doi.org/10.3389/fendo.2019.00165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437783PMC
March 2019
1 Read

Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction.

Front Endocrinol (Lausanne) 2019 20;10:160. Epub 2019 Mar 20.

Research Centre for Women's and Infants' Health, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.

Failure of uterine vascular transformation is associated with pregnancy complications including Intra Uterine Growth Restriction (IUGR). The decidua and its immune cell populations play a key role in the earliest stages of this process. Here we investigate the hypothesis that abnormal decidualization and failure of maternal immune tolerance in the second trimester may underlie the uteroplacental pathology of IUGR. Read More

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http://dx.doi.org/10.3389/fendo.2019.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436182PMC
March 2019
5 Reads

Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial.

Lancet 2019 Apr 1. Epub 2019 Apr 1.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK. Electronic address:

Background: Previous prospective cohort studies have shown that angiogenic factors have a high diagnostic accuracy in women with suspected pre-eclampsia, but we remain uncertain of the effectiveness of these tests in a real-world setting. We therefore aimed to determine whether knowledge of the circulating concentration of placental growth factor (PlGF), an angiogenic factor, integrated with a clinical management algorithm, decreased the time for clinicians to make a diagnosis in women with suspected pre-eclampsia, and whether this approach reduced subsequent maternal or perinatal adverse outcomes.

Methods: We did a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial in 11 maternity units in the UK, which were each responsible for 3000-9000 deliveries per year. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)33212-4DOI Listing
April 2019
2 Reads

Prenatal diagnosis of de novo monosomy 18p deletion syndrome by chromosome microarray analysis: Three case reports.

Medicine (Baltimore) 2019 Apr;98(14):e15027

Rationale: Monosomy 18p deletion syndrome refers to a rare chromosomal disorder resulting from the part deletion of the short arm of chromosome 18. Prenatal diagnosis of de novo 18p deletion syndrome is a challenge due to its low incidence and untypical prenatal clinical presentation.

Patient Concerns: Three cases received amniocentesis due to increased nuchal translucency (INT), high risk for Down syndrome, and INT combined intrauterine growth retardation (IUGR), respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000015027DOI Listing
April 2019
1 Read

Prenatal Malnutrition-Induced Epigenetic Dysregulation as a Risk Factor for Type 2 Diabetes.

Int J Genomics 2019 28;2019:3821409. Epub 2019 Feb 28.

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko, 76018 Ivano-Frankivsk, Ukraine.

Type 2 diabetes (T2D) is commonly regarded as a disease originating from lifestyle-related factors and typically occurring after the age of 40. There is, however, consistent experimental and epidemiological data evidencing that the risk for developing T2D may largely depend on conditions early in life. In particular, intrauterine growth restriction (IUGR) induced by poor or unbalanced nutrient intake can impair fetal growth and also cause fetal adipose tissue and pancreatic -cell dysfunction. Read More

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http://dx.doi.org/10.1155/2019/3821409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421750PMC
February 2019
1 Read

A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report.

BMC Pregnancy Childbirth 2019 Apr 3;19(1):116. Epub 2019 Apr 3.

Department of cardiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing's disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension, diabetes mellitus and an increased risk of fetal and maternal morbidity. Approximately 200 cases have been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12884-019-2262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448298PMC
April 2019
2 Reads

A case of immune-mediated type 1 diabetes mellitus due to congenital rubella ınfection.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):68-70. Epub 2019 Mar 31.

Child and Adolescent Psychiatry Unit, Dokuz Eylul University Hospital, Izmir, Turkey.

Congenital rubella infection is a transplacental infection that can cause intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and severe fetal injury. It has been shown that type 1 diabetes mellitus develops in 12%-20% of patients with congenital rubella infection, and disorders in the oral glucose tolerance test is observed in 40% of patients. No biochemical or serological markers exist which could indicate that type 1 diabetes was caused by a congenital rubella infection. Read More

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http://dx.doi.org/10.6065/apem.2019.24.1.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449622PMC

Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling.

J Cell Mol Med 2019 Apr 2. Epub 2019 Apr 2.

Muscle Research and Mitochondrial Function Laboratory, Faculty of Medicine and Health Sciences, Internal Medicine Service-Hospital Clínic of Barcelona, Cellex-IDIBAPS, University of Barcelona, Barcelona, Spain.

Intrauterine growth restriction (IUGR) is an obstetric complication characterised by placental insufficiency and secondary cardiovascular remodelling that can lead to cardiomyopathy in adulthood. Despite its aetiology and potential therapeutics are poorly understood, bioenergetic deficits have been demonstrated in adverse foetal and cardiac development. We aimed to evaluate the role of mitochondria in human pregnancies with IUGR. Read More

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http://dx.doi.org/10.1111/jcmm.14282DOI Listing
April 2019
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Hormonal Biomarkers for Evaluating the Impact of Fetal Growth Restriction on the Development of Chronic Adult Disease.

Rev Bras Ginecol Obstet 2019 Apr 2. Epub 2019 Apr 2.

Clinical Research Unit, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

The hypothesis of fetal origins to adult diseases proposes that metabolic chronic disorders, including cardiovascular diseases, diabetes, and hypertension originate in the developmental plasticity due to intrauterine insults. These processes involve an adaptative response by the fetus to changes in the environmental signals, which can promote the reset of hormones and of the metabolism to establish a "thrifty phenotype". Metabolic alterations during intrauterine growth restriction can modify the fetal programming. Read More

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http://dx.doi.org/10.1055/s-0039-1683904DOI Listing
April 2019
1 Read

Molecular Principles of Intrauterine Growth Restriction in Plasmodium Falciparum Infection.

Front Endocrinol (Lausanne) 2019 1;10:98. Epub 2019 Mar 1.

Placenta Lab, Department of Obstetrics, Jena University Hospital, Jena, Germany.

Malaria in pregnancy still constitutes a particular medical challenge in tropical and subtropical regions. Of the five species that are pathogenic to humans, infection with leads to fulminant progression of the disease with massive impact on pregnancy. Severe anemia of the mother, miscarriage, stillbirth, preterm delivery and intrauterine growth restriction (IUGR) with reduced birth weight are frequent complications that lead to more than 10,000 maternal and 200,000 perinatal deaths annually in sub-Saharan Africa alone. Read More

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http://dx.doi.org/10.3389/fendo.2019.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405475PMC
March 2019
2 Reads

Comparison of fetal size standards obtained with conventional methods and individualized assessment: the effect of adjusting for differences in growth potential.

J Matern Fetal Neonatal Med 2019 Mar 28:1-201. Epub 2019 Mar 28.

b Tulane University , New Orleans , Louisiana , USA.

Objective: Detection of fetal growth restriction depends on the biometric standard definitions of normal variability. We examined the impact of correcting for differences in fetal growth potential on the variability of third trimester size standards.

Methods: Size standards, corrected differences in growth potential using Individualized Growth Assessment [IGA], were obtained in 119 pregnancies with normal neonatal growth outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1601695DOI Listing
March 2019
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Placental expression of angiogenesis-related genes and their receptors in IUGR pregnancies: correlation with fetoplacental and maternal parameters.

J Matern Fetal Neonatal Med 2019 Mar 28:1-8. Epub 2019 Mar 28.

f Division of Molecular Medicine, St. John's Research Institute , St. John's National Academy of Health Sciences , Bangalore , India.

Objectives: Aberrations in placental vascular development compromising fetal supply of oxygen and essential nutrients can be a significant contributor to intrauterine growth restriction (IUGR). The development of placental vascular tree is under the influence of two families of growth factors, namely the vascular endothelial growth factor (VEGF) family and angiopoietin/TEK family. In this study, we have examined the expression of angiogenesis-related growth factors, mainly VEGF family and angiopoietin-TEK (endothelial-specific receptor tyrosine kinase) family genes in placentae from IUGR pregnancies uncomplicated by preeclampsia (PE) compared to normal pregnancies. Read More

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http://dx.doi.org/10.1080/14767058.2019.1593362DOI Listing
March 2019
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Genesis of placental sequestration in malaria and possible targets for drugs for placental malaria.

Authors:
Robert L Clark

Birth Defects Res 2019 Mar 28. Epub 2019 Mar 28.

Artemis Pharmaceutical Research, Jacksonville, Florida.

Malaria during pregnancy results in intrauterine growth restriction, fetal anemia, and infant mortality. Women are more susceptible to malaria during pregnancy due to malaria-induced inflammation and the sequestration of infected red blood cells in the placenta, which bind to the chondroitin sulfate portion of syndecan-1 on the syncytiotrophoblast and in the intervillous space. Syndecan-1 is a dimeric proteoglycan with an extracellular ectodomain that is cleaved from the transmembrane domain (referred to as "shedding") by matrix metalloproteinases (MMPs), likely the secreted MMP-9. Read More

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http://dx.doi.org/10.1002/bdr2.1496DOI Listing
March 2019
3 Reads

Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.

J Immunol 2019 Mar 27. Epub 2019 Mar 27.

Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Detroit, MI 48201;

Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity and mortality worldwide. Most research has focused on establishing a causal link between innate immune activation and pathological inflammation leading to preterm labor and birth. However, the role of maternal effector/activated T cells in the pathogenesis of preterm labor/birth is poorly understood. Read More

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http://dx.doi.org/10.4049/jimmunol.1801350DOI Listing
March 2019
2 Reads
4.922 Impact Factor

Placenta Transcriptome Profiling in Intrauterine Growth Restriction (IUGR).

Int J Mol Sci 2019 Mar 26;20(6). Epub 2019 Mar 26.

Department of Human Physiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Warszawska Str 30, 10-082 Olsztyn, Poland.

Intrauterine growth restriction (IUGR) is a serious pathological complication associated with compromised fetal development during pregnancy. The aim of the study was to broaden knowledge about the transcriptomic complexity of the human placenta by identifying genes potentially involved in IUGR pathophysiology. RNA-Seq data were used to profile protein-coding genes, detect alternative splicing events (AS), single nucleotide variant (SNV) calling, and RNA editing sites prediction in IUGR-affected placental transcriptome. Read More

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http://dx.doi.org/10.3390/ijms20061510DOI Listing
March 2019
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Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential.

Clinics (Sao Paulo) 2019 03 21;74:e894. Epub 2019 Mar 21.

Departamento de Ginecologia e Obstetricia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, BR.

The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and "omics" sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Read More

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http://dx.doi.org/10.6061/clinics/2019/e894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438130PMC
March 2019
2 Reads

Influence of Low Protein Diet-Induced Fetal Growth Restriction on the Neuroplacental Corticosterone Axis in the Rat.

Front Endocrinol (Lausanne) 2019 11;10:124. Epub 2019 Mar 11.

Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Placental steroid metabolism is linked to the fetal hypothalamus-pituitary-adrenal axis. Intrauterine growth restriction (IUGR) might alter this cross-talk and lead to maternal stress, in turn contributing to the pathogenesis of anxiety-related disorders of the offspring, which might be mediated by fetal overexposure to, or a reduced local enzymatic protection against maternal glucocorticoids. So far, direct evidence of altered levels of circulating/local glucocorticoids is scarce. Read More

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http://dx.doi.org/10.3389/fendo.2019.00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421269PMC
March 2019
2 Reads

Silencing of maternal hepatic glucocorticoid receptor is essential for normal fetal development in mice.

Commun Biol 2019 15;2:104. Epub 2019 Mar 15.

Signal Transduction Laboratory, Research Triangle Park, North Carolina USA.

Excessive or chronic stress can lead to a variety of diseases due to aberrant activation of the glucocorticoid receptor (GR), a ligand activated transcription factor. Pregnancy represents a particular window of sensitivity in which excessive stress can have adverse outcomes, particularly on the developing fetus. Here we show maternal hepatic stress hormone responsiveness is diminished via epigenetic silencing of the glucocorticoid receptor during pregnancy. Read More

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http://www.nature.com/articles/s42003-019-0344-3
Publisher Site
http://dx.doi.org/10.1038/s42003-019-0344-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420645PMC
March 2019
5 Reads

Postnatal Myocardial Function in Monochorionic Diamniotic Twins with Twin-to-Twin Transfusion Syndrome following Selective Laser Photocoagulation of the Communicating Placental Vessels.

J Am Soc Echocardiogr 2019 Mar 22. Epub 2019 Mar 22.

Department of Neonatology, The Rotunda Hospital, Dublin, Ireland; School of Medicine, Department of Pediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address:

Background: Monochorionic diamniotic (MCDA) twins are at risk for developing twin-to-twin transfusion syndrome (TTTS) throughout pregnancy. This may lead to myocardial dysfunction in the recipient and/or donor twin that persists beyond delivery. Selective laser photocoagulation of the communicating placental vessels (SLPCV) attempts to mitigate the cardiovascular outcomes. Read More

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http://dx.doi.org/10.1016/j.echo.2019.02.004DOI Listing
March 2019
1 Read

Prenatal findings and molecular cytogenetic analyses of a de novo interstitial deletion of 1q23.3 encompassing PBX1 gene.

Taiwan J Obstet Gynecol 2019 Mar;58(2):292-295

Prenatal Diagnostic Center, Dongguan Maternal and Children Health Hospital, Dongguan, Guangdong, People's Republic of China. Electronic address:

Objectives: To present the prenatal findings and the molecular cytogenetic analyses of a de novo interstitial deletion of 1q23.3 encompassing PBX1 gene.

Case Report: A 32-year-old woman (gravida 1, para 0) underwent amniocentesis at 26 weeks' gestation because of constant small fetal kidneys on prenatal ultrasound. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.022DOI Listing
March 2019
2 Reads