23,289 results match your criteria Fetal Growth Restriction


Prenatal imaging of genital defects: clinical spectrum and predictive factors for severe forms.

BJU Int 2019 Feb 18. Epub 2019 Feb 18.

Unité de Chirurgie Viscérale et Urologique Pédiatrique, Hôpital Lapeyronie - CHU Montpellier, France, et Université de Montpellier, France.

Objectives: 1-To report the clinical spectrum of genital defects diagnosed before birth, 2- to identify predictive factors for severe phenotypes at birth 3- to determine the rate of associated malformations.

Methods: A retrospective study (2008-2017) of 4580 fetuses identified prenatally with abnormalities evaluated by our Reference Center for Fetal Medicine included cases with fetal sonographic finding of abnormal genitalia or uncertainty of fetal sex determination. Familial, prenatal and postnatal data were collected through a standardized questionnaire. Read More

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http://dx.doi.org/10.1111/bju.14714DOI Listing
February 2019

A Pregnancy Cohort to Study Multidimensional Correlates of Preterm Birth in India: Study Design, Implementation, and Baseline Characteristics of the Participants.

Am J Epidemiol 2019 Feb 16. Epub 2019 Feb 16.

Regional Centre for Biotechnology, National Capital Region Biotech Cluster, Faridabad, Delhi NCR, India.

Globally, preterm birth is a major public health problem. In India, 3.6 million of the 27 million infants born annually are preterm. Read More

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http://dx.doi.org/10.1093/aje/kwy284DOI Listing
February 2019

A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks.

J Clin Endocrinol Metab 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynaecology, NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Context: Previous studies have shown reduced placental levels of 11-beta-hydroxysteroid dehydrogenase-type 2 (11βHSD2) in preeclampsia. However, it is not known if the maternal cortisol to cortisone ratio is predictive of placental complications of pregnancy.

Objective: To determine the relationship between the maternal serum cortisol to cortisone ratio at different stages of pregnancy and the risk of preeclampsia or fetal growth restriction (FGR). Read More

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http://dx.doi.org/10.1210/jc.2018-02312DOI Listing
February 2019

The placenta: A site of end-organ damage after Fontan operation. A case series.

Int J Cardiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL, United States of America.

Background: Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology.

Methods: We reviewed clinical charts and placental pathology from 7 women with Fontan physiology who had pregnancies at Mayo Clinic, Rochester, Minnesota. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.002DOI Listing
February 2019

Neurological development may be accelerated in growth-restricted fetuses: a 4D ultrasound study.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine, Miki, Kagawa, Japan.

Objective To assess whether neurological maturation and development are accelerated in fetal growth restriction (FGR) in utero using four-dimensional (4D) ultrasound. Methods The facial expressions of 50 appropriate-for-gestational-age (AGA) and 34 FGR fetuses aged between 28 and 35 gestational weeks were assessed using 4D ultrasound. Subsequently, they were differentiated into two gestational age groups (19 aged 28-31 weeks and 31 aged 32-35 weeks in AGA, and 15 aged 28-31 weeks and 19 aged 32-35 weeks in FGR). Read More

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http://dx.doi.org/10.1515/jpm-2018-0379DOI Listing
February 2019

Apparent Diffusion Coefficient of the Placenta and Fetal Organs in Intrauterine Growth Restriction.

J Comput Assist Tomogr 2019 Feb 11. Epub 2019 Feb 11.

From the Departments of Diagnostic Radiology and Obstetrics and Gynecology, Mansoura Faculty of Medicine, Mansoura. Egypt.

Purpose: This study aimed to assess apparent diffusion coefficient (ADC) of the placenta and fetal organs in intrauterine growth restriction (IUGR).

Materials And Methods: A prospective study of 30 consecutive pregnant women (aged 21-38 years with mean age of 31.5 years and a mean gestational week of 35 ± 2. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000844DOI Listing
February 2019

Third trimester uterine artery Doppler indices as predictors of preeclampsia and neonatal small for gestational age.

J Matern Fetal Neonatal Med 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Obstetrics and Gynecology , University of South Florida Morsani College of Medicine , Tampa , FL , USA.

Objective: To test the hypothesis that third-trimester uterine artery Doppler (UAD) predicts adverse pregnancy and neonatal outcomes in a high-risk population.

Study Design: This is a nested case control study of women with singleton gestations referred for a fetal growth ultrasound between 24 and 36 weeks. Third-trimester UAD was performed if estimated fetal weight (Hadlock's chart) was <20th percentile as these patients were considered high risk for poor pregnancy outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1575804DOI Listing
February 2019

Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 13. Epub 2019 Feb 13.

Perinatal Research Center, University of Colorado School of Medicine, United States.

Intrauterine growth restricted (IUGR) fetal sheep have increased hepatic glucose production (HGP) that is resistant to suppression during a hyperinsulinemic-isoglycemic clamp (insulin-clamp). We hypothesized that the IUGR fetal liver would have activation of metabolic and signaling pathways that support HGP and inhibition of insulin signaling pathways. To test this, we used transcriptomic profiling with liver samples from control (CON) and IUGR fetuses receiving saline or an insulin-clamp. Read More

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http://dx.doi.org/10.1152/ajpregu.00359.2018DOI Listing
February 2019

p53-Mediated activities in NS-5 neural stem cells: effects of ethanol.

Authors:
Michael W Miller

Alcohol Clin Exp Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Neuroscience and Physiology, State University of New York- Upstate Medical University, Syracuse, NY, 13210, USA.

Background: Transforming growth factor (TGF) β1 and ethanol powerfully inhibit the proliferation, DNA repair, and survival of neural stem cells (NSCs). The present study tests the hypothesis that the ethanol-induced DNA damage response is mediated through p53 pathways and influenced by growth factor signals.

Methods: Cultures of non-immortalized NSCs, NS-5 cells, were transfected with p53 siRNA, exposed to either the mitogenic fibroblast growth factor (FGF) 2 or anti-mitogenic TGFβ1, and to ethanol. Read More

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http://dx.doi.org/10.1111/acer.13976DOI Listing
February 2019

Lvrn expression is not critical for mouse placentation.

J Reprod Dev 2019 Feb 10. Epub 2019 Feb 10.

Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

Preeclampsia is a systemic disease caused by abnormal placentation that affects both mother and fetus. It was reported that Laeverin (LVRN, also known as Aminopeptidase Q) was up-regulated in the placenta of preeclamptic patients. However, physiological and pathological functions of LVRN remained to be unknown. Read More

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https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_201
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http://dx.doi.org/10.1262/jrd.2018-157DOI Listing
February 2019
7 Reads

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

Placenta 2019 Feb 4. Epub 2019 Feb 4.

Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address:

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.02.002DOI Listing
February 2019
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Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring.

Reprod Sci 2019 Feb 11:1933719119828041. Epub 2019 Feb 11.

1 Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Background:: The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown. Read More

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http://dx.doi.org/10.1177/1933719119828041DOI Listing
February 2019

Plasticity of the Maternal Vasculature During Pregnancy.

Annu Rev Physiol 2019 Feb;81:89-111

Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit. Read More

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http://dx.doi.org/10.1146/annurev-physiol-020518-114435DOI Listing
February 2019
2 Reads

The controversial role of the Ductus Venosus in hypoxic human fetuses.

Acta Obstet Gynecol Scand 2019 Feb 11. Epub 2019 Feb 11.

Department of Clinical Science, Intervention and Technology, Karolinska Institute and Center for Fetal Medicine, Karolinska University Hospital, Stockholm, Sweden.

The ductus venosus plays a critical role in circulatory adaptation to hypoxia in fetal growth restriction, but the mechanisms still remain controversial. Increased shunting of blood through the ductus venosus under hypoxic conditions has been shown in animal and human studies. The hemodynamic laws governing the accelerated flow in this vessel suggest that any dilatation at its isthmus, which increases the blood flow shunting to the heart, is associated with a low, absent or reversed a-wave, and a high pulsatility index. Read More

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http://dx.doi.org/10.1111/aogs.13572DOI Listing
February 2019

Increased Autophagy and Apoptosis in the Kidneys of Intrauterine Growth Restricted Rats.

Fetal Pediatr Pathol 2019 Feb 11:1-10. Epub 2019 Feb 11.

a Louisiana State University, Health Sciences Center , New Orleans , Louisiana , USA.

Background: IUGR has been associated with nephron loss and chronic kidney disease (CKD).

Materials And Methods: We examined autophagy and apoptosis markers in the kidneys of IUGR Sprague Dawley rats induced by maternal low protein diet (LP), comparing them to controls. The autophagy marker LC3B, the pro-apoptotic protein Bax, and the anti-apoptotic protein Bcl-2 were determined by quantitative immunoblotting. Read More

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http://dx.doi.org/10.1080/15513815.2018.1564160DOI Listing
February 2019

Umbilical artery pulsatility index and half-peak systolic velocity deceleration time in fetuses with trisomy 21.

J Matern Fetal Neonatal Med 2019 Feb 10:1-7. Epub 2019 Feb 10.

b Fetal Imaging Unit , FETALMED-Maternal-Fetal Diagnostic Center , Santiago , Chile.

Objective: To analyze placental vascular resistance and the role of placental insufficiency in the etiology of reduced fetal growth in fetuses with trisomy 21 as determined by umbilical artery (UA) Doppler velocimetry.

Methods: Second- and third-trimester UA Doppler ultrasound studies were performed in fetuses with trisomy 21 at the time of clinically indicated obstetric ultrasound assessment. The UA pulsatility index (PI) and half-peak systolic velocity deceleration time (hPSV-DT) were measured and recorded. Read More

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http://dx.doi.org/10.1080/14767058.2019.1575357DOI Listing
February 2019
1 Read

Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Sendai, 980-8578, Japan; Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. Electronic address:

Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia (PE). The flares of SLE during pregnancy or after delivery are also problematic. We have previously demonstrated that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress and improves PE-like phenotype and pregnancy outcomes in the mouse models of PE. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.110DOI Listing
February 2019
1 Read

Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception.

Horm Mol Biol Clin Investig 2019 Feb 11. Epub 2019 Feb 11.

Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.

Allopregnanolone (ALLO) has a crucial role in brain development and remodeling. Reproductive transitions associated with endocrine changes affect synthesis and activity of ALLO with behavioral/affective consequences. Pregnancy is characterized by an increased synthesis of progesterone/ALLO by the placenta, maternal and fetal brains. Read More

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http://dx.doi.org/10.1515/hmbci-2018-0032DOI Listing
February 2019
2 Reads

Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries.

Am J Obstet Gynecol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Rome, Italy.

We explore the potential role of the endothelial lining of uteroplacental arteries in the pathogenesis of preeclampsia, a severe pregnancy disorder characterized by incomplete invasion of the uterine vasculature by extravillous trophoblast and angiogenic imbalance. In normal pregnancy, the endothelium disappears progressively from the uteroplacental arteries and is replaced by trophoblast and deposition of fibro-fibrinoid structure, underpinning the so-called physiological transformation of uterine spiral arteries. We hypothesize that partial persistence of the endothelium, albeit injured, initiates a chain of events leading to the emergence of preeclampsia in three sequential stages. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.239DOI Listing
February 2019
2 Reads

Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy.

Immunity 2019 Jan 30. Epub 2019 Jan 30.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Zika virus (ZIKV) has recently been associated with birth defects and pregnancy loss after maternal infection. Because dengue virus (DENV) and ZIKV co-circulate, understanding the role of antibody-dependent enhancement in the context of pregnancy is critical. Here, we showed that the presence of DENV-specific antibodies in ZIKV-infected pregnant mice significantly increased placental damage, fetal growth restriction, and fetal resorption. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.005DOI Listing
January 2019
2 Reads

Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression.

J Physiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Physiology, The University of Melbourne, Parkville, VIC, 3010, Australia.

Key Points: Fetal growth is dependent on effective placental nutrient transportation, which is regulated by mTORC1 modulation of nutrient transporter expression. These transporters are dysregulated in pregnancies affected by uteroplacental insufficiency and maternal obesity. Nutrient transporters and mTOR were altered in placentae of mothers born growth restricted compared to normal birth weight dams, with maternal diet- and fetal sex-specific responses. Read More

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http://dx.doi.org/10.1113/JP277227DOI Listing
February 2019
1 Read

Reference charts for umbilical Doppler pulsatility index in fetuses with isolated two-vessel cord.

Arch Gynecol Obstet 2019 Feb 7. Epub 2019 Feb 7.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC), Sant' Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To determine reference values for umbilical Doppler pulsatility index in fetuses with isolated two-vessel cord and to compare these values with standard umbilical Doppler pulsatility index curves from 23 to 40 gestational weeks.

Methods: A retrospective longitudinal cohort study was conducted between January 2014 and December 2017 in a tertiary referral hospital and included 62 pregnant women with isolated single umbilical artery (two-vessel cord) and 174 measurements. Only uncomplicated term pregnancies were included. Read More

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http://dx.doi.org/10.1007/s00404-019-05086-zDOI Listing
February 2019

Response to: Placenta in intrauterine fetal demise (IUFD): a comprehensive study from a tertiary care hospital.

J Matern Fetal Neonatal Med 2019 Feb 6:1-11. Epub 2019 Feb 6.

a Brighton and Sussex Medical School , Eastern Road, Brighton , United Kingdom.

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http://dx.doi.org/10.1080/14767058.2019.1580261DOI Listing
February 2019

Vasoactive Intestinal Peptide shapes first trimester placenta trophoblast, vascular and immune cell cooperation.

Br J Pharmacol 2019 Feb 6. Epub 2019 Feb 6.

Maternal and Fetal Health Research Centre, University of Manchester, Manchester Academic Health Sciences Centre, St. Mary's Hospital, Manchester, M13 9WL, UK.

Background And Purpose: Extravillous trophoblast cells (EVT) are responsible for decidual stromal invasion, vascular transformation and the recruitment and functional modulation of maternal leukocytes in the first trimester pregnant uterus. An early disruption of EVT function leads to placental insufficiency underlying pregnancy complications such as preeclampsia and fetal growth restriction. Vasoactive intestinal peptide (VIP) is a vasodilating and immune modulatory factor synthesized by trophoblast cells. Read More

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http://dx.doi.org/10.1111/bph.14609DOI Listing
February 2019
2 Reads

Advances in the proteomics of amniotic fluid to detect biomarkers for chromosomal abnormalities and fetomaternal complications during pregnancy.

Expert Rev Proteomics 2019 Feb 5:1-10. Epub 2019 Feb 5.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM'S NMIMS , V.L. Mehta Road, Vile Parle west, Mumbai - 400056 , India.

Introduction: Amniotic fluid (AF) is a dynamic and complex mixture that reflects the physiological condition of developing fetus. In the last decade, proteomic analysis of AF for 16-18 weeks normal pregnancy has been done for the composition and functions of this fluid. Other body fluids such as urine, sweat, tears, etc. Read More

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http://dx.doi.org/10.1080/14789450.2019.1578213DOI Listing
February 2019
1 Read

The Subplate: A Potential Driver of Cortical Folding?

Cereb Cortex 2019 Feb 4. Epub 2019 Feb 4.

The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

In many species of Mammalia, the surface of the brain develops from a smooth structure to one with many fissures and folds, allowing for vast expansion of the surface area of the cortex. The importance of understanding what drives cortical folding extends beyond mere curiosity, as conditions such as preterm birth, intrauterine growth restriction, and fetal alcohol syndrome are associated with impaired folding in the infant and child. Despite being a key feature of brain development, the mechanisms driving cortical folding remain largely unknown. Read More

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https://academic.oup.com/cercor/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/cercor/bhz003DOI Listing
February 2019
3 Reads

Postnatal Expression Profile of microRNAs Associated with Cardiovascular and Cerebrovascular Diseases in Children at the Age of 3 to 11 Years in Relation to Previous Occurrence of Pregnancy-Related Complications.

Int J Mol Sci 2019 Feb 2;20(3). Epub 2019 Feb 2.

Institute for the Care of the Mother and Child, Third Faculty of Medicine, Charles University, 14700 Prague, Czech Republic.

Children descending from pregnancies complicated by gestational hypertension (GH), preeclampsia (PE) or fetal growth restriction (FGR) have a lifelong cardiovascular risk. The aim of the study was to verify if pregnancy complications induce postnatal alterations in gene expression of microRNAs associated with cardiovascular/cerebrovascular diseases. Twenty-nine microRNAs were assessed in peripheral blood, compared between groups, and analyzed in relation to both aspects, the current presence of cardiovascular risk factors and cardiovascular complications and the previous occurrence of pregnancy complications with regard to the clinical signs, dates of delivery, and Doppler ultrasound examination. Read More

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http://dx.doi.org/10.3390/ijms20030654DOI Listing
February 2019
2 Reads

Isolated acute funisitis in the absence of acute chorioamnionitis: What does it mean?

Placenta 2019 Jan 5;75:42-44. Epub 2018 Dec 5.

Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, 520 E 70th St, New York, NY, 10065, USA. Electronic address:

Objective: Acute funisitis (AF) is most commonly associated with acute chorioamnionitis (AC) and ascending infection. The significance of cases of AF without associated AC or isolated funisitis (IF) is unknown. Our objective was to evaluate clinical and pathologic features of IF and to determine its significance. Read More

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http://dx.doi.org/10.1016/j.placenta.2018.12.002DOI Listing
January 2019
1 Read

The prognostic accuracy of short term variation of fetal heart rate in early-onset fetal growth restriction: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 22;234:179-184. Epub 2019 Jan 22.

Amsterdam UMC, University of Amsterdam, Department of Obstetrics and Gynecology, Meibergdreef 9, Amsterdam, the Netherlands.

Objective: Cardiotocography (CTG) is an important tool for fetal surveillance in severe early-onset fetal growth restriction (FGR). Assessment of the CTG is usually performed visually (vCTG). However, it is suggested that computerized analysis of the CTG (cCTG) including short term variability (STV) could more accurately detect fetal compromise. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.005DOI Listing
January 2019

Critical time window of fenvalerate-induced fetal intrauterine growth restriction in mice.

Ecotoxicol Environ Saf 2019 Jan 29;172:186-193. Epub 2019 Jan 29.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui, China. Electronic address:

Fenvalerate (FEN), a representative type II pyrethroid, is a widely used pyrethroid insecticide and a potential environmental contaminant. Several studies demonstrated that gestational FEN exposure induced intrauterine growth restriction (IUGR). However, the critical time window of FEN-induced fetal IUGR remains obscure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193006
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http://dx.doi.org/10.1016/j.ecoenv.2019.01.054DOI Listing
January 2019
2 Reads

Prediction of small for gestational age neonates: Screening by maternal factors, fetal biometry and biomarkers at 35-37 weeks' gestation.

Am J Obstet Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Fetal Medicine Research Institute, King's College Hospital, London, UK. Electronic address:

Background: Small for gestational age (SGA) neonates are at increased risk of perinatal mortality and morbidity, but the risks can be substantially reduced if the condition is identified prenatally, because in such cases close monitoring and appropriate timing of delivery and prompt neonatal care can be undertaken. The traditional approach of identifying pregnancies with SGA fetuses is maternal abdominal palpation and serial measurements of symphysial-fundal height, but the detection rate of this approach is less than 30%. A higher performance of screening for SGA is achieved by sonographic fetal biometry during the third trimester; screening at 30-34 weeks' gestation identifies about 80% of SGA neonates delivering preterm but only 50% of those delivering at term, at screen positive rate of 10%. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.227DOI Listing
January 2019
2 Reads

Current and emerging pharmacotherapy for emergency management of preeclampsia.

Expert Opin Pharmacother 2019 Feb 1:1-12. Epub 2019 Feb 1.

a Ritchie Centre, Department of Obstetrics and GynaecologySchool of Clinical Sciences , Monash University , Clayton , Australia.

Introduction: Preeclampsia is a disease specific to pregnancy characterised by new onset hypertension with maternal organ dysfunction and/or fetal growth restriction. It remains a major cause of maternal and perinatal morbidity and mortality. For fifty years, antihypertensives have been the mainstay of treating preeclampsia, reducing maternal morbidity and mortality. Read More

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http://dx.doi.org/10.1080/14656566.2019.1570134DOI Listing
February 2019
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Association of Fetal Growth Restriction With Neurocognitive Function After Repeated Antenatal Betamethasone Treatment vs Placebo: Secondary Analysis of the ACTORDS Randomized Clinical Trial.

JAMA Netw Open 2019 Feb 1;2(2):e187636. Epub 2019 Feb 1.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Importance: Repeated doses of antenatal betamethasone are recommended for women at less than 32 weeks' gestation with ongoing risk of preterm birth. However, concern that this therapy may be associated with adverse neurocognitive effects in children with fetal growth restriction (FGR) remains.

Objective: To determine the influence of FGR on the effects of repeated doses of antenatal betamethasone on neurocognitive function in midchildhood. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7636DOI Listing
February 2019
5 Reads

Neu Laxova syndrome.

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):149-152

Department of Pathology, KLE University's Jawaharlal Nehru Medical College, Belagavi, Karnataka, India.

NeuLaxova syndrome (NLS) is a rare congenital abnormality involving multiple systems. Until date, only 60 cases of this syndrome have been reported in the literature. A stillborn fetus from a 23-year-old female with bad obstetrics history and consanguinity marriage, presented at 41 weeks gestation and not appreciating fetal movements for the past 3 days. Read More

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http://www.ijpmonline.org/text.asp?2019/62/1/149/251249
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http://dx.doi.org/10.4103/IJPM.IJPM_351_17DOI Listing
February 2019
2 Reads

Prenatal exposure to particulate matter and ozone: bulky DNA adducts, plasma isoprostanes, allele risk variants and neonate susceptibility in the Mexico City Metropolitan Area (MCMA).

Environ Mol Mutagen 2019 Jan 31. Epub 2019 Jan 31.

Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México.

Mexico City's Metropolitan Area (MCMA) includes Mexico City and 60 municipalities of the neighbor states. Inhabitants are exposed to emissions from over 5 million vehicles and stationary sources of air pollutants such as particulate matter (PM) and ozone. MCMA PM contains elemental (EC) and organic carbon (OC). Read More

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http://doi.wiley.com/10.1002/em.22276
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http://dx.doi.org/10.1002/em.22276DOI Listing
January 2019
2 Reads

Mortality in the UK STRIDER trial of sildenafil therapy for the treatment of severe early-onset fetal growth restriction.

Lancet Child Adolesc Health 2019 Mar 29;3(3):e2-e3. Epub 2019 Jan 29.

Department of Women's and Children's Health, University of Liverpool, Liverpool, L8 7SS, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(19)30020-3DOI Listing
March 2019
1 Read

Placental mesenchymal dysplasia: An underdiagnosed placental pathology with various clinical outcomes.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 17;234:155-164. Epub 2019 Jan 17.

Materno-Fetal and Obstetrics Research Unit, Department of Obstetrics and Gynecology, University Hospital, Lausanne, Switzerland. Electronic address:

Background: Placental mesenchymal dysplasia (PMD) is a rare vascular and connective placental anomaly, which is often associated with severe fetal and/or maternal complications. The diversity of presentation of PMD challenges diagnosis and effective pregnancy management.

Objective: We aimed to review cases presenting at 7 tertiary centers worldwide over the last decade and to study the occurrence of obstetric and neonatal complications. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.014DOI Listing
January 2019
2 Reads

Retardation of Axonal and Dendritic Outgrowth Is Associated with the MAPK Signaling Pathway in Offspring Mice Following Maternal Exposure to Nanosized Titanium Dioxide.

J Agric Food Chem 2019 Feb 13. Epub 2019 Feb 13.

Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection , Huaiyin Normal University , Huaian 223300 , China.

Exposure to nanosized titanium oxide (nano-TiO) has been proven to suppress brain growth in mouse offspring; however, whether retardation of axonal or dendritic outgrowth is associated with activation of the mitogen-activated protein kinase (MAPK) pathway remains unclear. In the present study, pregnant mice were exposed to nano-TiO at 1.25, 2. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06992DOI Listing
February 2019

In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging.

Pediatr Res 2019 Jan 25. Epub 2019 Jan 25.

Division of Diagnostic Imaging & Radiology, Children's National Health System, 111 Michigan Ave. NW, Washington, DC, 20010, USA.

Background: The objective of this study was to characterize structural changes in the healthy in vivo placenta by applying morphometric and textural analysis using magnetic resonance imaging (MRI), and to explore features that may be able to distinguish placental insufficiency in fetal growth restriction (FGR).

Methods: Women with healthy pregnancies or pregnancies complicated by FGR underwent MRI between 20 and 40 weeks gestation. Measures of placental morphometry (volume, elongation, depth) and digital texture (voxel-wise geometric and signal-intensity analysis) were calculated from T2W MR images. Read More

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http://dx.doi.org/10.1038/s41390-019-0311-1DOI Listing
January 2019

Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: protocol for an international cohort study.

BMJ Open 2019 Jan 29;9(1):e027941. Epub 2019 Jan 29.

School of Public Health, Curtin University, Bentley, Western Australia, Australia.

Introduction: Short interpregnancy interval (IPI) has been linked to adverse pregnancy outcomes. WHO recommends waiting at least 2 years after a live birth and 6 months after miscarriage or induced termination before conception of another pregnancy. The evidence underpinning these recommendations largely relies on data from low/middle-income countries. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02794
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http://dx.doi.org/10.1136/bmjopen-2018-027941DOI Listing
January 2019
2 Reads

Klotho Gene and Protein in Human Placentas According to Birth Weight and Gestational Age.

Front Endocrinol (Lausanne) 2018 15;9:797. Epub 2019 Jan 15.

School of Medicine, Maternal and Child Research Institute (IDIMI), University of Chile, Santiago, Chile.

Fetal growth restriction may be the consequence of maternal, fetal, or placental factors. The insulin-like growth factors (IGFs) are major determinants of fetal growth, and are expressed in the mother, fetus and placenta in most species. Previously we reported higher placental protein content of IGF-I, IGF-IR, and AKT in small (SGA) compared with those from appropriate for gestational age (AGA) placentas. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00797
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http://dx.doi.org/10.3389/fendo.2018.00797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340928PMC
January 2019
2 Reads

Single nucleotide polymorphism (SNP) based chromosomal microarray analysis provides clues and insights into disease mechanisms.

Ultrasound Obstet Gynecol 2019 Jan 28. Epub 2019 Jan 28.

Department of Genetics and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Chromosomal microarray analysis (CMA) in pregnancy is the modality of choice for prenatal diagnosis of fetal malformations, diagnosing microdeletion/duplication syndromes. We demonstrate further utilities of CMA, by diagnosing monogenic disease, imprinting disorders and uniparental disomy (UPD).

Methods: We performed CMA using Affymetrix CytoScan array for 6995 pregnancies for all indications since November 2013 in a tertiary referral hospital. Read More

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http://dx.doi.org/10.1002/uog.20230DOI Listing
January 2019
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Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial).

Trials 2019 Jan 28;20(1):85. Epub 2019 Jan 28.

King's College London, London, UK.

Background: Pre-eclampsia is a pregnancy disorder, characterised by hypertension and multisystem complications in the mother. The adverse outcomes of pre-eclampsia include severe hypertension, stroke, renal and hepatic injury, haemorrhage, fetal growth restriction and even death. The optimal time to instigate delivery to prevent morbidity when pre-eclampsia occurs between 34 and 37 weeks' gestation, without increasing problems related to infant immaturity or complications, remains unclear. Read More

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http://dx.doi.org/10.1186/s13063-018-3150-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350286PMC
January 2019
3 Reads

Association of cord blood ischemia-modified albumin level with abnormal foetal Doppler parameters in intrauterine growth-restricted foetuses.

J Matern Fetal Neonatal Med 2019 Jan 28:1-6. Epub 2019 Jan 28.

b Department of Biochemistry, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.

Objective: To investigate cord blood ischemia-modified albumin (IMA) levels in pregnancies with intrauterine growth restriction (IUGR) and to determine its association with abnormal fetal Doppler findings.

Methods: Umbilical cord IMA levels were assessed in 34 pregnant women with IUGR and 32 pregnancies with normal fetal development. Associations of IMA with abnormal umbilical artery Doppler findings, preeclampsia, and oligohydramnios were investigated. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1569623DOI Listing
January 2019
1 Read

Obstetric management, tests, and technologies that impact childhood development.

Dev Med Child Neurol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gynecology and Obstetrics, Division of Maternal-Fetal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Childhood brain development begins before birth, and obstetric management, tests, and technologies designed to diagnose and treat fetal conditions can have an impact on development. Preconception counseling for maternal diabetes and hypertension affect the risk of fetal congenital anomalies and growth restriction. Patients with risk factors for pre-existing maternal diabetes are offered early diabetic screening because earlier diagnosis and treatment can decrease the risk of fetal and neonatal complications. Read More

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http://dx.doi.org/10.1111/dmcn.14160DOI Listing
January 2019
4 Reads

Associations of antenatal glucocorticoid exposure with mental health in children.

Psychol Med 2019 Jan 28:1-11. Epub 2019 Jan 28.

Department of Psychology and Logopedics,Faculty of Medicine,University of Helsinki,Helsinki,Finland.

Background: Synthetic glucocorticoids, to enhance fetal maturation, are a standard treatment when preterm birth before 34 gestational weeks is imminent. While morbidity- and mortality-related benefits may outweigh potential neurodevelopmental harms in children born preterm (<37 gestational weeks), this may not hold true when pregnancy continues to term (⩾37 gestational weeks). We studied the association of antenatal betamethasone exposure on child mental health in preterm and term children. Read More

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https://www.cambridge.org/core/product/identifier/S003329171
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http://dx.doi.org/10.1017/S0033291718004129DOI Listing
January 2019
4 Reads

Early Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation.

Am J Perinatol 2019 Jan 27. Epub 2019 Jan 27.

Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Objective:  To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins with inflammatory, neurotrophic, or angiogenic properties.

Design:  Using multiplex immunoassays, we measured the concentrations of IGF-1 and IGFBP-1, as well as 25 other proteins in blood spots collected weekly from ≥ 880 infants born before the 28th week of gestation, and sought correlates of concentrations in the top and bottom quartiles for gestational age and day the specimen was collected.

Results:  Medically indicated delivery and severe fetal growth restriction (sFGR) were associated with low concentrations of IGF-1 on the first postnatal day and with high concentrations of IGFBP-1 on almost all days. Read More

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http://dx.doi.org/10.1055/s-0038-1677472DOI Listing
January 2019
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Maternal Haematological Parameters and Placental and Umbilical Cord Histopathology in Intrauterine Growth Restriction.

Med Princ Pract 2019 Jan 27. Epub 2019 Jan 27.

Objective:

There are literature data on the relationship between pregnancy outcomes and placental morphology, ultrasonic fetal biometry and arterial Doppler flow velocimetry in relation to placental morphometry We investigated the placental and umbilical cord histopathology in IUGR, and their relation with second trimester maternal haematological parameters.

Materials (Subjects) and Methods

Women were followed up with ultraonography and blood samples were taken between the 20-24th gestational weeks and they were selected for IUGR group based on estimated fetal weight below the 10th percentile. Patients were recruited in the control group randomly. Read More

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http://dx.doi.org/10.1159/000497240DOI Listing
January 2019
2 Reads

Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 23. Epub 2019 Jan 23.

Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado, Anschutz Medical Campus, Aurora, USA. Electronic address:

The most common cause of intrauterine growth restriction (IUGR) in the developed world is placental insufficiency, a concept often used synonymously with reduced utero-placental and umbilical blood flows. However, placental insufficiency and IUGR are associated with complex, coordinated and highly regulated changes in placental signaling and nutrient transport including inhibition of insulin and mTOR signaling and down-regulation of specific amino acid transporters, Na/K-ATPase, the NaH-exchanger, folate and lactate transporters. In contrast, placental glucose transport capacity is unaltered and Ca-ATPase activity and the expression of proteins involved in placental lipid transport are increased in IUGR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183051
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http://dx.doi.org/10.1016/j.bbadis.2018.12.024DOI Listing
January 2019
5 Reads

A double-hit pre-eclampsia model results in sex-specific growth restriction patterns.

Dis Model Mech 2019 Feb 8;12(2). Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands

Pre-eclampsia is a multifactorial pregnancy-associated disorder characterized by angiogenic dysbalance and systemic inflammation; however, animal models that combine these two pathophysiological conditions are missing. Here, we introduce a novel double-hit pre-eclampsia mouse model that mimics the complex multifactorial conditions present during pre-eclampsia and allows for the investigation of early consequences for the fetus. Adenoviral overexpression of soluble fms-like tyrosine kinase (sFlt-1) and lipopolysaccharide (LPS) administration at mid-gestation in pregnant mice resulted in hypertension and albuminuria comparable to that of the manifestation in humans. Read More

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http://dx.doi.org/10.1242/dmm.035980DOI Listing
February 2019
1 Read