24,897 results match your criteria Fetal Growth Restriction


Maternal sildenafil impairs the cardiovascular adaptations to chronic hypoxemia in fetal sheep.

J Physiol 2020 Aug 4. Epub 2020 Aug 4.

The Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynecology, Monash University, Melbourne, Australia.

Key Points: Fetal growth restriction induces a hemodynamic response which aims to maintain blood flow to vital organs such as the brain, in the face of chronic hypoxemia Maternal sildenafil treatment impairs the hypoxemia-driven hemodynamic response and potentially compromises fetal development.

Abstract: Background Inadequate substrate delivery to a fetus results in hypoxemia and fetal growth restriction (FGR). In response, fetal cardiovascular adaptations redirect cardiac output to essential organs to maintain oxygen delivery and sustain development. Read More

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http://dx.doi.org/10.1113/JP279248DOI Listing

Effect and mechanism of prophylactic use of tadalafil during pregnancy on l-NAME-induced preeclampsia-like rats.

Placenta 2020 Jul 20;99:35-44. Epub 2020 Jul 20.

Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, 300162, China. Electronic address:

Introduction: Preeclampsia (PE) is a serious maternal inflammatory disease with endothelial cell dysfunction, and there is a lack of effective treatment and prevention. Tadalafil is considered to be a promising drug for PE. This study aimed to determine whether and how tadalafil use during early pregnancy alleviates PE induced by N-nitro-l-arginine-methyl-ester (l-NAME), an antagonist of nitric oxide synthase, in rats. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.06.015DOI Listing

Placental SARS-CoV-2 in a Pregnant Woman with Mild COVID-19 Disease.

J Med Virol 2020 Aug 4. Epub 2020 Aug 4.

MU Center for Research on Influenza Systems Biology (CRISB), University of Missouri, Columbia, MO, USA.

Background: The full impact of COVID-19 on pregnancy remains uncharacterized. Current literature suggests minimal maternal, fetal, and neonatal morbidity and mortality. COVID-19 manifestations appear similar between pregnant and non-pregnant women. Read More

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http://dx.doi.org/10.1002/jmv.26386DOI Listing

Quantification of Wave Reflection in the Human Umbilical Artery from Asynchronous Doppler Ultrasound Measurements.

IEEE Trans Med Imaging 2020 Jun 23;PP. Epub 2020 Jun 23.

Elevated umbilical artery pulsatility is a widely used biomarker for placental pathology leading to intra-uterine growth restriction and, in severe cases, still-birth. It has been hypothesized that placental pathology modifies umbilical artery pulsatility by altering the degree to which the pulse pressure wave, which originates from the fetal heart, is reflected from the placental vasculature to interfere with the incident wave. Here we present a method for estimating the reflected pulse wave in the umbilical artery of human fetuses using asynchronously acquired Doppler ultrasound measurements from the two ends of the umbilical cord. Read More

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http://dx.doi.org/10.1109/TMI.2020.3004511DOI Listing

The relationship between circadian blood pressure variability and maternal/perinatal outcomes in women with preeclampsia with severe features.

Hypertens Pregnancy 2020 Aug 3:1-6. Epub 2020 Aug 3.

Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong , Hong Kong.

Objective: To determine whether circadian blood pressure (BP) variation of women with preeclampsia (PE) with severe features was associated with adverse maternal/perinatal outcomes.

Methods: 173 women with PE with severe features were recruitedand categorized into three groups: dipper, non-dipper and reverse dipper type BP group.. Read More

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http://dx.doi.org/10.1080/10641955.2020.1797777DOI Listing

Hyperphosphorylation of fetal liver IGFBP-1 precedes slowing of fetal growth in nutrient restricted baboons and may be a mechanism underlying IUGR.

Am J Physiol Endocrinol Metab 2020 Aug 3. Epub 2020 Aug 3.

Biochemistry and Pediarics, University of Western Ontario, Canada.

In cultured fetal liver cells, IGFBP-1 hyperphosphorylation in response to hypoxia and amino acid deprivation is mediated by inhibition of mechanistic target of rapamycin (mTOR) and activation of amino acid response (AAR) signalling and casein kinase CK2. We hypothesized that fetal liver mTOR inhibition, activation of AAR and CK2, and IGFBP-1 hyperphosphorylation occur prior to development of intrauterine growth restriction (IUGR). Pregnant baboons were fed a Control (C) or a Maternal Nutrient Restriction (MNR; 70% calories of Control) diet starting at gestational day (GD) 30 (Term GD185). Read More

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http://dx.doi.org/10.1152/ajpendo.00220.2020DOI Listing

Advanced maternal age and adverse pregnancy outcomes.

Best Pract Res Clin Obstet Gynaecol 2020 Jul 15. Epub 2020 Jul 15.

St George's University Hospital NHS Foundation Trust, Fetal Medicine Unit, 4th Floor, Lanesborough Wing, Blackshaw Road, Tooting, SW17 0QT, UK. Electronic address:

A wide range of adverse pregnancy outcomes are associated with women of advanced maternal age (AMA). These include increased risks for miscarriage, chromosomal abnormalities, stillbirth, foetal growth restriction, preterm birth, pre-eclampsia, gestational diabetes mellitus and caesarean section. While a wide body of literature has reported on these risks, varying definitions in both AMA and reported outcomes can make synthesizing the information difficult when counselling an individual women about her specific risks. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2020.07.005DOI Listing

Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice.

BMC Dev Biol 2020 Aug 3;20(1):17. Epub 2020 Aug 3.

Molecular Cell Biology Unit, Center for Inflammation Research, VIB, Technologiepark 71, B-9052, Ghent, Belgium.

Background: p120 catenin (p120ctn) is an important component in the cadherin-catenin cell adhesion complex because it stabilizes cadherin-mediated intercellular junctions. Outside these junctions, p120ctn is actively involved in the regulation of small GTPases of the Rho family, in actomyosin dynamics and in transcription regulation. We and others reported that loss of p120ctn in mouse embryos results in an embryonic lethal phenotype, but the exact developmental role of p120ctn during brain formation has not been reported. Read More

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http://dx.doi.org/10.1186/s12861-020-00222-4DOI Listing

Proposing a new approach to measuring birth size asymmetry.

Paediatr Perinat Epidemiol 2020 Jun 17. Epub 2020 Jun 17.

School of Public Health, Curtin University, Perth, WA, Australia.

Background: Existing methods of measuring birth size asymmetry based on ratios of growth parameters are clinically useful but simplistic, and as such may have limited usefulness in studies of aetiology.

Objectives: We aimed to develop a novel method of measuring asymmetric fetal growth at birth and demonstrate its utility in characterising the perturbed growth associated with a number of prenatal exposures and neonatal outcomes.

Methods: Data were drawn from the Queensland (QLD) Perinatal Data Collection, which included all livebirths in the Australian state of QLD between July 2010 and December 2015, with analyses restricted to babies born between 32 and 42 weeks of gestation (n = 280 084). Read More

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http://dx.doi.org/10.1111/ppe.12684DOI Listing

Survival Outcomes by Fetal Weight Discordance after Laser Surgery for Twin-Twin Transfusion Syndrome Complicated by Donor Fetal Growth Restriction.

Fetal Diagn Ther 2020 Jul 31:1-10. Epub 2020 Jul 31.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA,

Introduction: Management options for treatment of twin-twin transfusion syndrome (TTTS) with severe donor intrauterine growth restriction (IUGR) include fetoscopic laser surgery and umbilical cord occlusion (UCO). We studied perinatal survival outcomes in this select group after laser surgery, stratifying patients by preoperative estimated fetal weight (EFW) discordance.

Methods: In this retrospective study of monochorionic diamniotic twin gestations with TTTS and selective donor IUGR who underwent laser surgery (2006-2017), preoperative EFW discordance was calculated ([(larger twin - smaller twin)/(larger twin)] × 100) and cases were divided into discordance strata. Read More

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http://dx.doi.org/10.1159/000509032DOI Listing

Adverse intrapartum outcome in pregnancies complicated by small for gestational age and late fetal growth restriction undergoing induction of labor with Dinoprostone, Misoprostol or mechanical methods: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2020 Jul 18;252:455-467. Epub 2020 Jul 18.

Department of Obstetrics and Gynecology, Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address:

Objective: To investigate the outcome of pregnancies with small baby, including both small for gestational age (SGA) and late fetal growth restriction (FGR) fetuses, undergoing induction of labor (IOL) with Dinoprostone, Misoprostol or mechanical methods.

Study Design: Medline, Embase and Cochrane databases were searched. Inclusion criteria were non-anomalous singleton pregnancies complicated by the presence of a small fetus, defined as a fetus with estimated fetal weight (EFW) or abdominal circumference (AC) <10th centile undergoing IOL from 34 weeks of gestation with vaginal Dinoprostone, vaginal misoprostol, or mechanical methods (including either Foley or Cook balloon catheters). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.07.020DOI Listing

ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction.

Ultrasound Obstet Gynecol 2020 Aug;56(2):298-312

Department of Maternal Fetal Medicine, Royal Women's Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/uog.22134DOI Listing

Factors Associated with Occurrence of Stillbirth before 32 Weeks of Gestation in a Contemporary Cohort.

Am J Perinatol 2020 Jul 31. Epub 2020 Jul 31.

Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Objective:  We sought to quantify the distribution of stillbirths by gestational age (GA) in a contemporary cohort and to determine identifiable risk factors associated with stillbirth prior to 32 weeks of gestation.

Study Design:  Population-based case-control study of all stillbirths in the United States during the year 2014, utilizing vital statistics data, obtained from the National Center for Health Statistics. Distribution of stillbirths were stratified by 20 to 44 weeks of GA, in women diagnosed with stillbirth in the antepartum period. Read More

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http://dx.doi.org/10.1055/s-0040-1714421DOI Listing

Elective cesarean delivery and long-term cardiovascular morbidity in the offspring - a population-based cohort analysis.

J Matern Fetal Neonatal Med 2020 Jul 30:1-8. Epub 2020 Jul 30.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: To evaluate the impact of cesarean delivery (CD) on offspring risk for long-term cardiovascular morbidity.

Study Design: A population-based cohort analysis was performed, including all singleton term deliveries occurring between 1991 and 2014 at a single tertiary medical center. A comparison was performed between children delivered via CD and those delivered vaginally. Read More

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http://dx.doi.org/10.1080/14767058.2020.1797668DOI Listing

Outcomes of radiofrequency ablation for selective fetal reduction in complicated monochorionic pregnancies performed before 16 gestational weeks and thereafter.

Ultrasound Obstet Gynecol 2020 Jul 30. Epub 2020 Jul 30.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

Objective: To investigate the risk factors associated the loss of the co-twin after selective fetal reduction in monochorionic (MC) multiple pregnancies using radiofrequency ablation (RFA) performed before 16 gestational weeks and thereafter.

Methods: This was a single-center retrospective analysis of 63 consecutive RFA indicated for twin reversed arterial perfusion sequence (13 cases), twin-to-twin transfusion syndrome (12 cases), twin anemia-polycythemia sequence (2 cases), selective fetal growth restriction (10 cases), discordant anomalies (17 cases), and multifetal pregnancy reduction (9 cases) for triplets or quadruplets with a MC pair. Twenty-six of them (41. Read More

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http://dx.doi.org/10.1002/uog.22160DOI Listing

Severe fever with thrombocytopenia syndrome virus infection during pregnancy in C57/BL6 mice causes fetal damage.

PLoS Negl Trop Dis 2020 Jul 30;14(7):e0008453. Epub 2020 Jul 30.

Department of Microbiological Laboratory Technology, School of Public Health, Cheeloo College of Medicine, Shandong University, Key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, Shandong Province, China.

Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne phlebovirus, which is listed in the most dangerous pathogens by the World Health Organization, and has 12-30% fatality rates. SFTSV antibodies were reported in minks that experienced abortion or reproductive failure. The aim of this study was to determine whether SFTSV infection causes an adverse pregnancy outcome in the fetus using a pregnant mouse model. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008453DOI Listing

Impact of implementation of a breech clinic in a tertiary hospital.

BMC Pregnancy Childbirth 2020 Jul 29;20(1):435. Epub 2020 Jul 29.

Department of Obstetrics and Gynecology, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Université Libre de Bruxelles (ULB), 808 route de Lennik, B-1070, Bruxelles, Belgium.

Background: The incidence of breech presentation in single pregnancies at term is between three to 5 %. In order to support eligible women in their choice of mode of delivery, a dedicated breech clinic with a care pathway was developed in December 2015 in a tertiary referral centre in Brussels. The primary objective of this study was to evaluate the vaginal birth rate before and after the introduction of a dedicated breech clinic. Read More

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http://dx.doi.org/10.1186/s12884-020-03122-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391516PMC

Understanding and Preventing Placenta-Mediated Pregnancy Complications.

Hamostaseologie 2020 Aug 29;40(3):356-363. Epub 2020 Jul 29.

Department of Haematology, School of Medicine, University College Dublin, Rotunda Hospital and Mater University Hospital, Irish Network for VTE Research (INViTE), Dublin, Ireland.

Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evolving. In this narrative review, we will present the latest evidence to better understand hemostatic mechanisms of preeclampsia, as well as in women with placenta-mediated pregnancy complications and inherited thrombophilia or antiphospholipid antibodies. Read More

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http://dx.doi.org/10.1055/a-1184-8388DOI Listing

RELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR TYPE 1 AND INTRAUTERINE GROWTH.

Acta Clin Croat 2020 Mar;59(1):91-96

1Department of Neonatology, Clinical Center of Montenegro, Podgorica, Montenegro; 2Institute of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; 3Center for Physical Medicine and Rehabilitation, Clinical Center of Montenegro, Podgorica, Montenegro; 4Institute of Children's Diseases, Clinical Center of Montenegro, Podgorica, Montenegro; 5The Obstetrics and Gynaecology Clinic Narodni Front, Belgrade, Serbia.

Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. Read More

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http://dx.doi.org/10.20471/acc.2020.59.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382880PMC

Adverse perinatal outcomes of chronic intervillositis of unknown etiology: an observational retrospective study of 122 cases.

Sci Rep 2020 Jul 28;10(1):12611. Epub 2020 Jul 28.

Department of Internal Medicine, Bordeaux University Hospital, Bordeaux, France.

Our study aimed to assess perinatal outcomes and recurrence rate of Chronic Intervillositis of Unknown Etiology (CIUE). We conducted an observational retrospective study in a tertiary care university hospital in France from January 1, 1997 to July 31, 2018. 122 pregnancies (102 women) with CIUE were included. Read More

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http://dx.doi.org/10.1038/s41598-020-69191-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387519PMC

Critical Coarctation of the Aorta in Selective Fetal Growth Restriction and the Role of Coronary Stent Implantation.

Fetal Diagn Ther 2020 Jul 27:1-9. Epub 2020 Jul 27.

Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Leuven, Belgium,

Introduction: Monochorionic twins are at increased risk of congenital heart defects (CHDs). Up to 26% have a birth weight <1,500 g, a CHD requiring neonatal surgery, therefore, poses particular challenges.

Objective: The aim of the study was to describe pregnancy characteristics, perinatal management, and outcome of monochorionic twins diagnosed with critical coarctation of the aorta (CoA). Read More

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http://dx.doi.org/10.1159/000508305DOI Listing

Long-term renal disease after prematurity or fetal growth restriction: who is at risk?

Nephrol Dial Transplant 2020 Jul 28. Epub 2020 Jul 28.

Department of Obstetrics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfaa167DOI Listing

Influence of Environmental Tobacco Smoke and Air Pollution on Fetal Growth: A Prospective Study.

Int J Environ Res Public Health 2020 Jul 23;17(15). Epub 2020 Jul 23.

Department of Nursing and Graduate Institute of Nursing, College of Nursing, Chang Gung University of Science and Technology (CGUST), Chiayi County, Puzi 613016, Taiwan.

Exposure to air pollution during pregnancy leads to adverse pregnancy outcomes. Few studies have evaluated the influences of air quality, including environmental tobacco smoke (ETS) and particulate matter (PM), on fetal development, which this study examined. This longitudinal correlation study used multiple linear regression data analysis of PM/PM, self-reported ETS exposure, urinary cotinine level, maternal characteristics, and birth parameters (gestational week, body weight, body length, head, and chest circumferences) with the effect of air quality on fetal growth. Read More

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http://dx.doi.org/10.3390/ijerph17155319DOI Listing

Population-Based Birth Cohort Studies in Epidemiology.

Int J Environ Res Public Health 2020 Jul 23;17(15). Epub 2020 Jul 23.

Laboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.

Birth cohort studies are the most appropriate type of design to determine the causal relationship between potential risk factors during the prenatal or postnatal period and the health status of the newborn up to childhood and potentially adulthood. To date, there has been a growth in interest regarding observational population-based studies which are performed to provide answers to specific research questions for defined populations, for instance, assessing the exposure to environmental pollutants or drugs on the risk of developing a disease. Birth cohorts based on the recruitment and active follow-up of mothers and children allow the collection of biological material, and specific clinical and genetic information. Read More

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http://dx.doi.org/10.3390/ijerph17155276DOI Listing

Protease-activated receptor 2 contributes to placental development and fetal growth in mice.

Thromb Res 2020 Jul 2;193:173-179. Epub 2020 Jul 2.

Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan; Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Sendai 980-8578, Japan. Electronic address:

Background: Protease-activated receptor 2 (PAR2) is activated by serine proteases such as coagulation tissue factor/VIIa complex, factor Xa or trypsin and is pro-angiogenic in several disease models. Impaired angiogenesis in placenta causes placental dysfunction and fetal growth restriction. PAR2 is expressed in the placenta trophoblast. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.06.039DOI Listing

Albumin promotes the progression of fibroblasts through late G into S-phase in the absence of growth factors.

Cell Cycle 2020 Jul 26:1-10. Epub 2020 Jul 26.

Department of Biological Sciences, Hunter College of the City University of New York , New York, NY, USA.

G cell cycle progression is controlled largely by growth factors in early G indicating that it is appropriate to divide and by nutrients in late G indicating sufficient raw material for cell division. We previously mapped a late G cell cycle checkpoint for lipids upstream from a mammalian target of rapamycin complex 1 (mTORC1)-mediated checkpoint and downstream from a mid-G checkpoint known as the Restriction point. We therefore investigated a role for lipids in progression through late G into S-phase. Read More

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http://dx.doi.org/10.1080/15384101.2020.1795999DOI Listing

Risk factors for antepartum death in term pregnancies.

J Matern Fetal Neonatal Med 2020 Jul 26:1-6. Epub 2020 Jul 26.

Clinical Research Center, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Objective: To identify risk factors for antepartum fetal death (APD) in term pregnancies while considering maternal, pregnancy and fetal characteristics.

Materials And Methods: Our study took place between the years 1988-2013. A total of 272,527 singleton births at term were recorded during this time period, including 524 cases of APD (0. Read More

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http://dx.doi.org/10.1080/14767058.2020.1797664DOI Listing

Epidemiological studies regarding hypertensive disorders of pregnancy: A review.

J Obstet Gynaecol Res 2020 Jul 26. Epub 2020 Jul 26.

Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.

A hypertensive disorder of pregnancy (HDP) is defined as hypertension emerging after 20 weeks of gestation and resolving up to 12 weeks post-partum, and occurs in about 5% of all pregnancies. Complications associated with HDP have poor prognoses, and maternal deaths attributable to HDP are predicted to exceed 70 000 per year worldwide. Understanding the pathogenesis and risk factors of hypertensive disorders of pregnancy is important, and they are often investigated in observational studies. Read More

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http://dx.doi.org/10.1111/jog.14383DOI Listing

Hemodynamic Complications in Pregnancy: Preeclampsia and Beyond.

Clin Perinatol 2020 Sep 20;47(3):653-670. Epub 2020 May 20.

The Centre for Women's and Infant's Health, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Canada; Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Sinai Health System, University of Toronto, Canada.

Normal pregnancy is a complex and dynamic process that requires significant adaptation from the maternal system. Failure of this adaptive process in pregnancy contributes to many pregnancy related disorders, including the hypertensive disorders of pregnancy. This article discusses placental development and how abnormalities in the process of vascular remodeling contribute to the multisystem maternal and fetal disease that is preeclampsia and fetal growth restriction. Read More

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http://dx.doi.org/10.1016/j.clp.2020.05.014DOI Listing
September 2020

Cerebral Autoregulation in Sick Infants: Current Insights.

Clin Perinatol 2020 Sep 14;47(3):449-467. Epub 2020 May 14.

Division of Neonatology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands.

Cerebrovascular autoregulation is the ability to maintain stable cerebral blood flow within a range of cerebral perfusion pressures. When cerebral perfusion pressure is outside the limits of effective autoregulation, the brain is subjected to hypoperfusion or hyperperfusion, which may cause vascular injury, hemorrhage, and/or hypoxic white matter injury. Infants born preterm, after fetal growth restriction, with congenital heart disease, or with hypoxic-ischemic encephalopathy are susceptible to a failure of cerebral autoregulation. Read More

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http://dx.doi.org/10.1016/j.clp.2020.05.003DOI Listing
September 2020

The melatonin and enriched environment ameliorated Low protein-induced intrauterine growth retardation by IGF-1 and mTOR signaling pathway and autophagy inhibition in rats.

Curr Mol Med 2020 Jul 26. Epub 2020 Jul 26.

Department of basic medical, HE's University, Shenyang, Liaoning 110163. China.

Aim: The present study investigated whether melatonin (MEL) and enriched environment (EE) might protect against intrauterine growth retardation (IUGR) rats.

Methods: Sprague-Dawley rats were randomly allocated to 3 groups: control (C), model (M) and EE+MEL group. Animals were housed in enriched environment (EE+MEL group) or remained in a standard environment (C group, M group). Read More

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http://dx.doi.org/10.2174/1566524020666200726221735DOI Listing

Association between in vitro fertilization and ischemic placental disease by gestational age.

Fertil Steril 2020 Jul 21. Epub 2020 Jul 21.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Electronic address:

Objective: To evaluate the association between in vitro fertilization (IVF) and ischemic placental disease (IPD), stratified by gestational age.

Design: We performed a secondary analysis of a retrospective cohort study of deliveries.

Setting: Deliveries were performed over 15 years at a single tertiary hospital. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.04.029DOI Listing

sFlt-1/PlGF ratio for the prediction of delivery within 48 hours and adverse outcomes in expectantly managed early-onset preeclampsia.

Pregnancy Hypertens 2020 Jul 15;22:17-23. Epub 2020 Jul 15.

Fetal Medicine Unit, Maternal and Child Health and Development Network (Red SAMID-RD12/0026/0016), Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital, 12 de Octubre (imas12). Av. de Córdoba, s/n, 28041 Madrid, Spain; Universidad Complutense de Madrid, Av. Séneca, 2, 28040 Madrid, Spain. Electronic address:

Objective: To analyze if sFlt-1/PlGF ratio is more useful than other parameters at diagnosis of early-onset (<34 weeks) preeclampsia (PE) in the prediction of delivery within 48 h and adverse maternal and perinatal outcomes.

Method: Observational retrospective study of a cohort of 76 singleton pregnancies with early-onset PE and expectant management. The predictive value of sFlt-1/PlGF ratio, blood pressure, proteinuria, creatinine, liver enzymes and platelets at diagnosis for delivery < 48 h and adverse outcomes was determined. Read More

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http://dx.doi.org/10.1016/j.preghy.2020.07.007DOI Listing

The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude.

J Dev Orig Health Dis 2020 Jul 24:1-12. Epub 2020 Jul 24.

Laboratory of Vascular Function and Reactivity, Pathophysiology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Chronic hypoxia during gestation induces greater occurrence of perinatal complications such as intrauterine growth restriction, fetal hypoxia, newborn asphyxia, and respiratory distress, among others. This condition may also cause a failure in the transition of the fetal to neonatal circulation, inducing pulmonary arterial hypertension of the neonate (PAHN), a syndrome that involves pulmonary vascular dysfunction, increased vasoconstrictor tone and pathological remodeling. As this syndrome has a relatively low prevalence in lowlands (~7 per 1000 live births) and very little is known about its prevalence and clinical evolution in highlands (above 2500 meters), our understanding is very limited. Read More

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http://dx.doi.org/10.1017/S2040174420000616DOI Listing
July 2020
0.765 Impact Factor

Pregnancy environment, and not preconception, leads to fetal growth restriction and congenital abnormalities associated with diabetes.

Sci Rep 2020 Jul 23;10(1):12254. Epub 2020 Jul 23.

Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, 1960 East-West Rd, Honolulu, HI, 96822, USA.

Maternal diabetes can lead to pregnancy complications and impaired fetal development. The goal of this study was to use a mouse model of reciprocal embryo transfer to distinguish between the preconception and gestational effects of diabetes. To induce diabetes female mice were injected with a single high dose of streptozotocin and 3 weeks thereafter used as oocyte donors for in vitro fertilization (IVF) and as recipients for embryo transfer. Read More

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http://dx.doi.org/10.1038/s41598-020-69247-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378839PMC

Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency.

Cell Death Dis 2020 Jul 23;11(7):560. Epub 2020 Jul 23.

Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, and Charité - Universitätsmedizin Berlin, Berlin, Germany.

Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity and mortality. To date, no approved treatment is available for pregnant women affected with FGR. Read More

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http://dx.doi.org/10.1038/s41419-020-02791-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378206PMC

Micro-anatomic alterations of the placenta in a non-human primate model of gestational protein-restriction.

PLoS One 2020 23;15(7):e0235840. Epub 2020 Jul 23.

Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.

Objectives: Maternal protein malnutrition is associated with impaired fetal growth, and lifetime consequences for the offspring. Our group has previously developed a model of protein-restriction in the non-human primate, which was associated with fetal growth restriction, stillbirth, decreased placental perfusion, and evidence of fetal hypoxia, suggesting perturbed vascular development. Our objective was to histologically characterize the micro-anatomic alterations associated with adverse pregnancy outcomes taking an approach that permits investigation of the 3D vascular structure and surrounding histology without the requirement for 3D vascular casting or relying on 2D stereology which both have methodological limitations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235840PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377450PMC

Testosterone Decreases Placental Mitochondrial Content and Cellular Bioenergetics.

Biology (Basel) 2020 Jul 20;9(7). Epub 2020 Jul 20.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA.

Placental mitochondrial dysfunction plays a central role in the pathogenesis of preeclampsia. Since preeclampsia is a hyperandrogenic state, we hypothesized that elevated maternal testosterone levels induce damage to placental mitochondria and decrease bioenergetic profiles. To test this hypothesis, pregnant Sprague-Dawley rats were injected with vehicle or testosterone propionate (0. Read More

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http://dx.doi.org/10.3390/biology9070176DOI Listing

Placental growth factor as a predictive marker of preeclampsia - PREBIO study - PREeclampsia BIOchemical study.

J Matern Fetal Neonatal Med 2020 Jul 20:1-7. Epub 2020 Jul 20.

Department of Obstetrics and Gynecology, University of Milano-Bicocca, MBBM Foundation, S. Gerardo Hospital, Monza, Italy.

Introduction: To evaluate the clinical utility of placental growth factor (PlGF) for the prediction of preeclampsia (PE).

Materials And Methods: This prospective cohort study included women divided into three groups: (1) pregnancies without preconceptional risk of developing PE; (2) pregnancies with a preconceptional and/or current risk of developing PE; (3) PE-complicated pregnancies (control group). Blood samples were collected every 4-5 weeks or during hospitalization from early second trimester until delivery in the group 1 and 2, at the diagnosis of PE in the group 3. Read More

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http://dx.doi.org/10.1080/14767058.2020.1792878DOI Listing

Maternal irisin level in last trimester isolated intrauterine growth-restriction.

J Matern Fetal Neonatal Med 2020 Jul 20:1-7. Epub 2020 Jul 20.

Department of Perinatology, Zekai Tahir Burak Women Health Care Education and Research Hospital, Ankara, Turkey.

Purpose: Intrauterine Growth Restriction (IUGR) is the inability of the fetus to achieve the biologically accessible growth potential. Irisin is a recently discovered adipomyokine with a crucial role in energy metabolism. Our current study aimed to investigate the relationship between the isolated IUGR in the third trimester and maternal serum irisin level. Read More

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http://dx.doi.org/10.1080/14767058.2020.1793315DOI Listing

Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress.

Hypertension 2020 Jul 20:HYPERTENSIONAHA12015235. Epub 2020 Jul 20.

From the Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, CA.

Hypoxia during pregnancy profoundly affects uterine vascular adaptation and increases the risk of pregnancy complications, including preeclampsia and fetal intrauterine growth restriction. We recently demonstrated that increases in Ca sparks and spontaneous transient outward currents (STOCs) played an essential role in pregnancy-induced uterine vascular adaptation. In the present study, we hypothesize that gestational hypoxia suppresses Ca sparks/STOCs coupling leading to increased uterine vascular tone via enhanced endoplasmic reticulum (ER)/oxidative stress. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15235DOI Listing

First trimester preeclampsia screening and prediction.

Am J Obstet Gynecol 2020 Jul 16. Epub 2020 Jul 16.

Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR. Electronic address:

Preeclampsia is a major cause of maternal and perinatal morbidity and mortality. Early onset disease requiring preterm delivery is associated with a higher risk of complications in both mothers and babies. Evidence suggests that the administration of low dose aspirin initiated prior to 16 weeks' gestation significantly reduces the rate of preterm preeclampsia. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.07.020DOI Listing

Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study.

J Steroid Biochem Mol Biol 2020 Jul 15;203:105729. Epub 2020 Jul 15.

Department of Obstetrics and Gynecology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, United States; Lawrence D. Longo MD Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, United States. Electronic address:

Vitamin D deficiency has been associated with preeclampsia, however, vitamin D supplementation studies have shown equivocal data on amelioration of this disease. We hypothesize that women with preeclampsia have an altered endogenous vitamin D homeostasis that counteracts the beneficial effects of vitamin D supplementation. Our study population consisted of 66 maternal/neonate dyads: 16 early-onset (<34 weeks) preeclampsia (EOP), 16 early-onset controls (EOC), 17 late-onset (≥34 weeks) preeclampsia (LOP), and 17 late-onset controls (LOC). Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105729DOI Listing

Maternal total cell-free DNA in preeclampsia with and without intrauterine growth restriction.

Sci Rep 2020 Jul 16;10(1):11848. Epub 2020 Jul 16.

Center for Prenatal Biomarker Research, CHA Advanced Research Institute, Seongnam, Korea.

Elevation of total cell-free DNA (cfDNA) in patients with preeclampsia is well-known; however, whether this change precedes the onset of symptoms remains inconclusive. Here, we conducted a nested case-control study to determine the elevation of cfDNA levels in women who subsequently developed preeclampsia. Methylated HYP2 (m-HYP2) levels were determined in 68 blood samples collected from women with hypertensive disorders of pregnancy, along with 136 control samples, using real-time quantitative PCR. Read More

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http://dx.doi.org/10.1038/s41598-020-68842-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367308PMC

BAFF attenuates oxidative stress-induced cell death by the regulation of mitochondria membrane potential via Syk activation in WiL2-NS B lymphoblasts.

Sci Rep 2020 Jul 16;10(1):11784. Epub 2020 Jul 16.

Department of Integrative Bioscience and Biotechnology, Sejong University, 209 Neungdong-ro Kwangjin-gu, Seoul, 05006, Republic of Korea.

Cell survival is facilitated by the maintenance of mitochondrial membrane potential (MMP). B cell activating factor (BAFF) plays a role in survival, differentiation, and maturation of B cells. In the present study, we examined whether BAFF could attenuate oxidative stress-induced B cell death by the regulation of MMP collapse via spleen tyrosine kinase (Syk) activation using WiL2-NS human B lymphoblast cells. Read More

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http://dx.doi.org/10.1038/s41598-020-68628-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366908PMC

Characterizing placental stiffness using ultrasound shear-wave elastography in healthy and preeclamptic pregnancies.

Arch Gynecol Obstet 2020 Jul 16. Epub 2020 Jul 16.

School of Medicine and Health Sciences, The George Washington University, Washington, D.C., USA.

Purpose: To measure the stiffness of the placenta in healthy and preeclamptic patients in the second and third trimesters of pregnancy using ultrasound shear-wave elastography (SWE). We also aimed to evaluate the effect of age, gestational age, gravidity, parity and body mass index (BMI) on placental stiffness and a possible correlation of stiffness with perinatal outcomes.

Methods: In a case-control study, we recruited a total of 47 singleton pregnancies in the second and third trimesters of which 24 were healthy and 23 were diagnosed with preeclampsia. Read More

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http://dx.doi.org/10.1007/s00404-020-05697-xDOI Listing

Premature or Small for Gestational Age Discrimination: International Multicenter Trial Protocol for Classification of the Low-Birth-Weight Newborn Through the Optical Properties of the Skin.

JMIR Res Protoc 2020 Jul 14;9(7):e16477. Epub 2020 Jul 14.

Faculty of Medicine, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Brazil.

Background: A low birth weight is an independent risk factor for adverse infant outcomes and a predictor of chronic disease in adulthood. In these situations, differentiating between prematurity and small for gestational age (SGA) or simultaneous conditions is essential to ensuring adequate care. Such diagnoses, however, depend on reliable pregnancy dating, which can be challenging in developing countries. Read More

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http://dx.doi.org/10.2196/16477DOI Listing

Twin pregnancy after kidney transplantation: case report and systematic review.

J Bras Nefrol 2020 Jul 15. Epub 2020 Jul 15.

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Divisão de Nefrologia, Unidade de Transplante Renal, Laboratório de Investigação em Transplante, Campinas, SP, Brasil.

Background: Kidney transplantation is associated with fertility restoration in more than 50% of women with chronic kidney disease. Pregnancy after transplantation may affect women's health and fetal development, with higher rates of abortion, fetal growth restriction, and neonatal deaths. Twin pregnancy is a condition of high-risk for adverse maternal and perinatal outcomes, and its occurrence in women with previous kidney transplantation is rare. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2020-0016DOI Listing

A long-term study of the effects of SLC12A1 homozygous mutation (g.62382825G>A, p.Pro372Leu) in Japanese Black cattle.

Anim Sci J 2020 Jan;91(1):e13415

Faculty of Agriculture, University of the Ryukyus, Nishihara, Okinawa, Japan.

Recessive missense mutation in the solute carrier family 12, member 1 (SLC12A1) gene (g.62382825G>A) is associated with hydrallantois, which is the accumulation of fluid in the allantoic cavity of a pregnant animal, and usually causes fetal death in Japanese Black cattle. However, the symptoms of a homozygote with this mutation that do not result in fetal death have not previously been tracked and evaluated. Read More

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http://dx.doi.org/10.1111/asj.13415DOI Listing
January 2020

A Novel Frame Shift Variant (c.7511delA) Causing Osteodysplastic Primordial Dwarfism of Majewski Type 2 (MOPD II).

Front Pediatr 2020 25;8:340. Epub 2020 Jun 25.

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Microcephalic osteodysplastic primordial dwarfism type II (MOPD II) is an autosomal recessive and skeletal disorder included wide spectrum of clinical abnormalities such as fetal growth restriction, disproportionate face, microcephaly, post-natal growth retardation, adult height under 100 cm, abnormal skin pigmentation, insulin resistance, and susceptibility to cerebrovascular and hematologic abnormalities. Due to heterogeneous feature of MOPDs diseases and common clinical features among the different subtypes, mutation analysis can be considered as fundamental in the accurate diagnosis and confirmation of the MOPD II disease. Some studies revealed that, variants of gene encoding Pericentrin protein, , were associated with MOPD II. Read More

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http://dx.doi.org/10.3389/fped.2020.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330014PMC