102,997 results match your criteria Fertility and sterility[Journal]


miR-505-3p is a repressor of the puberty onset in female mice.

J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

J Xiao, The College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.

Puberty onset is a complex trait regulated by multiple genetic and environmental factors. In this study, we narrowed a puberty related QTL region down to a 1.7 Mb region on chromosome X in female mice and inferred miR-505-3p as the functional gene. Read More

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December 2018

Corrigendum: Urinary Luteinizing Hormone Tests: Which Concentration Threshold Best Predicts Ovulation?

Front Public Health 2018 30;6:345. Epub 2018 Nov 30.

Service de Biostatistique, Hospices Civils de Lyon, Lyon, France.

[This corrects the article DOI: 10.3389/fpubh.2017. Read More

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November 2018

Effects of . on Matured Mouse Oocytes and Granulosa Cells.

Avicenna J Med Biotechnol 2018 Oct-Dec;10(4):220-226

Department of Biology, Faculty of Sciences, Shiraz University, Shiraz, Iran.

Background: According to previous studies, L. (dill) aqueous extracts decreased the fertility of female rats. Therefore, the present study aimed to examine the effects of this herb on cultured granulosa cells and immature oocytes. Read More

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December 2018

Molecular mechanisms regulating lifespan and environmental stress responses.

Inflamm Regen 2018 10;38:22. Epub 2018 Dec 10.

RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047 Japan.

Throughout life, organisms are subjected to a variety of environmental perturbations, including temperature, nutrient conditions, and chemical agents. Exposure to external signals induces diverse changes in the physiological conditions of organisms. Genetically identical individuals exhibit highly phenotypic variations, which suggest that environmental variations among individuals can affect their phenotypes in a cumulative and inhomogeneous manner. Read More

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December 2018

The Influence of Pentraxin 3 on the Ovarian Function and Its Impact on Fertility.

Front Immunol 2018 29;9:2808. Epub 2018 Nov 29.

Histology and Embryology Section, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy.

Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in order to obtain a follicle with full ovulatory and steroidogenic capability. A low-grade inflammation can alter such processes leading to premature arrest of follicular growth and female reproductive failure. Read More

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November 2018
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Endometriosis Is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis?

Front Endocrinol (Lausanne) 2018 29;9:725. Epub 2018 Nov 29.

Pannon Reproduction Institute, Tapolca, Hungary.

Approximately, 10-15% of women of reproductive age are affected by endometriosis, which often leads to infertility. Endometriosis often has an inherited component, and several causative predisposing factors are hypothesized to underlie the pathogenesis of endometriosis. One working hypothesis is the theory of retrograde menstruation. Read More

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November 2018

Mid-Luteal 17-OH Progesterone Levels in 614 Women Undergoing IVF-Treatment and Fresh Embryo Transfer-Daytime Variation and Impact on Live Birth Rates.

Front Endocrinol (Lausanne) 2018 29;9:690. Epub 2018 Nov 29.

The Fertility Clinic, Herlev University Hospital, Herlev, Denmark.

Corpus luteum (CL) produces progesterone (P) and 17-OH progesterone (17-OH P) during the luteal phase. Contrary to P, 17-OH P is not supplied as part of the luteal phase support following IVF-treatment. Therefore, measuring endogenous serum 17-OH P levels may more accurately reflect the CL function compared to monitoring serum P concentrations. Read More

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November 2018

Maternal Age and Offspring's Educational Attainment.

J Marriage Fam 2018 Aug 22;80(4):853-870. Epub 2018 May 22.

Department of Sociology, University of North Carolina-Chapel Hill, Hamilton Hall, Chapel Hill, NC 27599.

Utilizing data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), the current study examines which maternal age at birth provides offspring with optimal opportunities for higher educational attainment. The results show that maternal age has a curvilinear relationship with offspring's educational attainment, i.e. Read More

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Age × stage-classified demographic analysis: a comprehensive approach.

Ecol Monogr 2018 Nov 11;88(4):560-584. Epub 2018 Jul 11.

Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands.

This paper presents a comprehensive theory for the demographic analysis of populations in which individuals are classified by both age and stage. The earliest demographic models were age classified. Ecologists adopted methods developed by human demographers and used life tables to quantify survivorship and fertility of cohorts and the growth rates and structures of populations. Read More

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November 2018

Factors Associated With Intention of Future Pregnancy Among Women Affected by the Fukushima Nuclear Accident: Analysis of Fukushima Health Management Survey Data From 2012 to 2014.

J Epidemiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine.

Background: Little is known about the association between the anxiety toward the effects of radiation on reproduction caused by the Fukushima nuclear accident and the birth rate of people in Fukushima. Therefore, we examined changes and associated factors of future pregnancy intention among mothers in Fukushima Prefecture.

Methods: Using data from three postal surveys among women who registered their pregnancies in the prefecture (N = 6,751 in 2012, N = 6,871 in 2013, and N = 6,725 in 2014), we analyzed the factors associated with women's intention of future pregnancy using multivariable logistic regression models. Read More

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December 2018

Genomewide identification of PPR gene family and prediction analysis on restorer gene in .

J Genet 2018 Dec;97(5):1083-1095

Laboratory of Cotton Genetics, Genomics and Breeding/Key Laboratory of Crop Heterosis and Utilization of Ministry of Education/Beijing Key Laboratory of Crop Genetic Improvement, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, People's Republic of China.

Pentatricopeptide repeat (PPR) gene family plays an essential role in the regulation of plant growth and organelle gene expression. Some PPR genes are related to fertility restoration in plant, but there is no detailed information in . In the present study, we identified 482 and 433 PPR homologues in (D) and (A) genomes, respectively. Read More

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December 2018

Five financial incentives to revive the Gulf of Mexico dead zone and Mississippi basin soils.

J Environ Manage 2018 Dec 13;233:30-38. Epub 2018 Dec 13.

The Nature Conservancy, Arlington, VA, USA.

A central challenge in the Mississippi River Basin is how to continue to support profitable agricultural production, provide water supply, flood control, transportation, and other benefits, while reducing the current burden of environmental degradation. Several practices have been shown to reduce nutrient runoff and water pollution, and improve soil fertility, while often yielding profits for farmers. Yet many of these beneficial practices remain underutilized. Read More

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December 2018
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Testicular morphology and spermatogenesis in harbour porpoises (Phocoena phocoena).

Theriogenology 2018 Nov 28;126:177-186. Epub 2018 Nov 28.

Institute for Anatomy, University of Veterinary Medicine Hanover Foundation, Bischofsholer Damm 15, 30173, Hanover, Germany. Electronic address:

Knowledge about reproductive parameters in male harbour porpoises such as testicular histology and germ cell maturation as well as seasonal changes in spermatogenesis is scarce. Thus, the aim of the present study was to report changes in the histological appearance of the testicular morphology of neonatal and juvenile harbour porpoises during maturation, to identify stages of spermatogenesis in adult males and to detect seasonal modifications. The identification of these stages can be used to assess the developmental profile of gene expression during spermatogenesis and to identify defects in spermatogenesis arising in pathological conditions. Read More

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November 2018

Surrogacy and ethics in women with cancer.

Authors:
Susan V Carr

Best Pract Res Clin Obstet Gynaecol 2018 Nov 9. Epub 2018 Nov 9.

Faculty of Medicine, University of Melbourne, Parkville, Australia. Electronic address:

Women diagnosed with gynaecological cancer may face unwanted loss of fertility as well as all the other life-changing issues with which cancer and its treatments are associated. The decision to harvest and store gametes has to be made before commencement of treatment, and advances in these techniques have made this successful. Fertility sparing therefore must be discussed and offered at an early stage post diagnosis. Read More

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November 2018

Assisted reproductive technologies in Africa: first results from the African Network and Registry for Assisted Reproductive Technology, 2013.

Reprod Biomed Online 2018 Nov 22. Epub 2018 Nov 22.

African Fertility Society.

Research Question: What were utilization, outcomes and practices in assisted reproductive technology (ART) in Africa in 2013?

Design: To initiate a data registry in Africa, retrospective summary data were collected in a cross-sectional survey.

Results: Forty ART centres from 13 countries collectively reported 25,770 initiated cycles. Regional ART utilization could not be established due to large inter-country variations and insufficient data. Read More

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November 2018

Reproductive response to male joining with ewes with different allelic variants of the MTNR1A gene.

Anim Reprod Sci 2018 Nov 28. Epub 2018 Nov 28.

Department of Veterinary Medicine, Sassari University, Via Vienna 2, 07100, Sassari, Italy. Electronic address:

The aims were to evaluate the reproductive response to ram placement with Sarda ewes with different allelic variants at position g.15099485 A > G of the MTNR1 A gene. Ram placements occurred between the early and late spring and there was analysis of whether this polymorphism is associated with other nucleotide substitutions. Read More

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November 2018

Radiations and female fertility.

Reprod Biol Endocrinol 2018 Dec 16;16(1):112. Epub 2018 Dec 16.

Department of Medical and Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Faculty of Medicine and Psychology, University of Rome "Sapienza", Rome, Italy.

Hundreds of thousands of young women are diagnosed with cancer each year, and due to recent advances in screening programs, diagnostic methods and treatment options, survival rates have significantly improved. Radiation therapy plays an important role in cancer treatment and in some cases it constitutes the first therapy proposed to the patient. However, ionizing radiations have a gonadotoxic action with long-term effects that include ovarian insufficiency, pubertal arrest and subsequent infertility. Read More

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December 2018

Fms-like tyrosine kinase 3 is a key factor of male fertility.

Theriogenology 2018 Dec 8;126:145-152. Epub 2018 Dec 8.

Department of Animal Science & Technology, Chung-Ang University, Anseong, Gyeonggi-Do, 17546, Republic of Korea. Electronic address:

Fms-like tyrosine kinase 3 (FLT3) is a type III kinase that is highly expressed in seminal plasma of infertile men. FLT3 activation can be blocked by inhibition of its phosphorylation using the nontoxic and selective inhibitor, quizartinib. We investigated the function of FLT3 and the corresponding effects of quizartinib in mouse spermatozoa. Read More

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December 2018
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Demarcating the dirty work: Canadian Fertility professionals' use of boundary-work in contentious egg donation.

Authors:
Skye A Miner

Soc Sci Med 2018 Dec 1;221:19-26. Epub 2018 Dec 1.

Department of Sociology, McGill University, Room 712, Leacock Building, 855 Sherbrooke Street West, Montreal, QC, H3A 2T7, Canada. Electronic address:

The potential medical risks to egg donors, in addition to the concern over the commodification of life, has led to debates surrounding the ethics of paying donors. In Canada, payment for eggs is prohibited by law; however, what is considered payment is contentious and has yet to be defined. The lack of legislative clarity coupled with increased ethical concerns over paying a donor has shifted egg donation from a medically-controlled procedure to a legal and social endeavor involving multiple professionals. Read More

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December 2018

Design of a randomized controlled trial on the efficacy of a reproductive health survivorship care plan in young breast cancer survivors.

Contemp Clin Trials 2018 Dec 12. Epub 2018 Dec 12.

Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Dr. La Jolla, CA 92093-090, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, 9300 Campus Pointe Drive, MC 7433, La Jolla, CA 92037, USA. Electronic address:

Background: Young breast cancer survivors (YBCS) have unmet needs for managing hot flashes, fertility-related concerns, sexual health and contraception.

Purpose: Describe the design and participant characteristics of a randomized controlled trial testing the efficacy of the survivorship care plan on reproductive health (SCP-R) intervention on improving hot flashes, fertility-related concerns, sexual health, and contraception in YBCS.

Methods: SCP-R is a web-based intervention with text message support encompassing evidence- based practices on four reproductive health issues. Read More

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December 2018

Operative hysteroscopy for retained products of conception: Efficacy and subsequent fertility.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

AP-HP, Department of Gynecology and Obstetrics, Hospital Bicêtre, GHU Sud, F-94276, Le Kremlin Bicêtre, France; INSERM, U1018, Centre of research in Epidemiology and population health (CESP), F-94276, Le Kremlin Bicêtre, France; Faculty of medicine, University Paris Saclay, F-94276, Le Kremlin Bicêtre, France.

Retained product of conception complicates nearly 1% of pregnancies and can lead to synechiae and compromise ulterior fertility. The aim of this study is to evaluate efficiency of operative hysteroscopy in management of retained products of conception (RPOC). Secondary objectives are assessments of intra-uterine adhesions rate and later fertility. Read More

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December 2018
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Proteins, transcripts, and genetic architecture of seminal fluid and sperm in the mosquito .

Mol Cell Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Biology & Biochemistry, Syracuse University, United States of America

The yellow fever mosquito, , transmits several viruses causative of serious diseases, including dengue, Zika, and chikungunya. Some proposed efforts to control this vector involve manipulating reproduction to suppress wild populations or to replace them with disease-resistant mosquitoes. The design of such strategies requires an intimate knowledge of reproductive processes, yet our basic understanding of reproductive genetics in this vector remains largely incomplete. Read More

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December 2018
2 Reads

Cytochrome P450 (CYP450,2D6*A), N-Acetyltransferase-2 (NAT2*7, A) and Multidrug Resistance 1 (MDR1 3435 T) Alleles Collectively Increase Risk of Ulcerative Colitis.

Arch Iran Med 2018 Nov 1;21(11):530-535. Epub 2018 Nov 1.

Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: Discovering the association between genetic variations of metabolizing enzymes with idiopathic diseases such as ulcerative colitis (UC) may not only be an auxiliary agent in diagnosis but also could be an effective pharmacotherapy for inflammatory bowel disease (IBD). The aim of the present case-control study was to determine the association of cytochrome P450 2D6 (CYP2D6 *4), N-acteyltransferase-2 (NAT2*7) and multidrug resistance 1 (MDR1) 3435 C/T genotypes with UC susceptibility and thiopurine methyltransferase (TPMT) enzyme activity.

Methods: TPMT activity was measured by high performance liquid chromatography (HPLC) and genotypes for the 3 mentioned polymorphisms were determined in 215 unrelated UC patients and 212 unrelated healthy controls by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) in a Kurdish population from Iran. Read More

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November 2018

Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?

Biomed Pharmacother 2019 Jan 6;109:1126-1139. Epub 2018 Nov 6.

Dental School of São Paulo State University, Department of Morphology, Araraquara, Brazil. Electronic address:

The selective serotonin reuptake inhibitor fluoxetine has been used for the treatment of depression. Although sexual disorders have been reported in male patients, few studies have demonstrated the fluoxetine effect on the reproductive histophysiology, and the target of this antidepressant in testes is unknown. We evaluated the impact of short-term treatment with fluoxetine on the adult rat testes, focusing on steroidogenesis by Leydig cells (LC) and androgen-dependent testicular parameters, including Sertoli cells (SC) and peritubular myoid cells (PMC). Read More

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January 2019

Long-term follow-up of vitrified and autografted baboon (Papio anubis) ovarian tissue.

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, Brussels 1200, Belgium.

Study Question: Can vitrified baboon ovarian tissue survive >5 months after autotransplantation and subsequently restore fertility?

Summary Answer: Our results show that ovarian tissue grafts can survive at least 18 months, but fertility restoration could not be confirmed due to lack of pregnancy.

What Is Known Already: Ovarian function in baboons can be re-established after autografting of vitrified-warmed ovarian tissue fragments.

Study Design, Size, Duration: Ovaries from five adult female baboons were used for this study. Read More

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December 2018
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Ostrich egg yolk improves post thaw quality and in vivo fertility of Nili Ravi buffalo (Bubalus bubalis) bull spermatozoa.

Theriogenology 2018 Dec 6;126:140-144. Epub 2018 Dec 6.

Semen Production Unit Qadirabad, Sahiwal, Pakistan. Electronic address:

Egg yolk containing higher ratio of phospholipids and cholesterol may have better cryoprotective effect to buffalo spermatozoa during cryopreservation. Our objectives were to ascertain the comparison of Ostrich and chicken egg yolk in semen extender on post thaw quality, motion dynamics and in vivo fertility of Nili Ravi buffalo (Bubalus bubalis) bull spermatozoa. Semen samples (n = 45) from five bulls were collected once a week for a period of nine weeks and diluted in Triladyl extender having different concentrations of Ostrich egg yolk (10%, 15%, 20%) and 20% chicken egg yolk as control at 37 °C. Read More

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December 2018

Impact of selenium nano-particles in semen extender on bull sperm quality after cryopreservation.

Theriogenology 2018 Dec 5;126:121-127. Epub 2018 Dec 5.

Animal Production Research Institute, Dokki, Giza, Egypt.

The aim of this study was to evaluate the effect of adding different concentrations of selenium nano-particles (Se-NPs) in semen extender on bull sperm cryopreservation. Five healthy, fertile Friesian bulls were used, and the ejaculates were obtained using an artificial vagina. Semen of all bulls were pooled and diluted in a tris-yolk fructose (TYF) extender supplemented with Se-NPs at concentrations of 0 (T1, control), 0. Read More

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December 2018
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Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs.

Mol Cell Endocrinol 2018 Dec 11. Epub 2018 Dec 11.

Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address:

The aim of the present study was to compare the effect of oral and subcutaneous exposure to a glyphosate-based herbicide (GBH) on the female reproductive system, specifically in the ovaries and uterus of prepubertal lambs. To this end, ewe lambs were exposed to a s.c. Read More

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December 2018

Development and initial validation of the Positive Sexuality Scale for female adults.

Authors:
Giulia Casu

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, University of Bologna, Bologna, Italy.

Aim And Objectives: To develop and initially validate the Positive Sexuality Scale (PSS) to assess adult female positive sexuality.

Background: While traditional approaches focus on negative sexual experiences and sexual dysfunctions, within the positive psychology framework positive sexuality is a subjective experience of happiness and fulfillment with one's sexual expression, which contributes to well-being. No measure exists that specifically measures adult female positive sexuality and can be confidently used with women of any fertility/childlessness status. Read More

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December 2018
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Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment.

PLoS One 2018 14;13(12):e0209417. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.

Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice. Read More

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December 2018

Decrease in American birth rates makes it imperative for the United States to implement state mandated fertility coverage.

J Med Econ 2018 Dec 14:1-5. Epub 2018 Dec 14.

a McGill University Reproductive Center , 888 Boulevard de Maisonneuve East , Montréal , QC H2L 4S8 , Quebec , Canada.

In recent years, the prevalence of infertility has increased due to delayed child bearing and increase in the rate of male infertility. Given the high cost of fertility treatment, this option is not valid for families with low income, and those who can afford it usually choose to have multiple embryo transfers, which has led to an increase in multiple birth rates and increase in the cost of perinatal care. Due to the expected increase in infertility and decrease in the national live birth rate, the United States should set a plan to fund infertility treatment and lead a policy for single embryo transfer. Read More

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December 2018

Preconception management of women with obesity: A systematic review.

Obes Rev 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine (Austin Health), University of Melbourne, Heidelberg Heights, Victoria, Australia.

The prevalence of women of child-bearing age with obesity continues to rise at an alarming rate. This has significant implications for both the short-term and long-term health of mother and offspring. Given the paucity of evidence-based literature in this field, the preconception management of women with obesity is highly variable both between institutions and around the world. Read More

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December 2018
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Differential gene expression profile in monocytic myeloid-derived suppressor cells at maternal-fetal interface in a mouse model of spontaneous abortion.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Abstractbackground: Monocytic myeloid-derived suppressor cells (MO-MDSCs) play an important role in maintaining normal pregnancy. However, it is still not clear what kind of changes in MO-MDSCs may lead to miscarriage, and which gene expression changes take place when MO-MDSCs migrate to the uterus as bone marrow-derived cells.

Methods: We used flow sorting technology to obtain MO-MDSCs from the maternal-fetal interface and bone marrow, respectively. Read More

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December 2018
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Carry-over effects of early thermal conditions on somatic and germline oxidative damages are mediated by compensatory growth in sticklebacks.

J Anim Ecol 2018 Nov 22. Epub 2018 Nov 22.

Departamento de Ecoloxía e Bioloxía Animal, Universidade de Vigo, Vigo, Spain.

Most studies of climate change impacts focus on the effects of summer temperatures, which can immediately impact fitness of breeders, but winter temperatures are expected to have a greater impact on development and growth of animals with long-lasting consequences. Exposure to warmer temperatures can increase cellular oxidative damage in ectotherms. Yet, it is unknown whether thermal stress during early life has prolonged effects on oxidative status during adulthood. Read More

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November 2018

Cancer risk among children conceived by fertility treatment.

Int J Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Hunan, China.

Prior studies on the association between fertility treatment and childhood cancer risk have generated inconsistent results. We performed a systematic review and meta-analysis of observation studies to summarize the evidence regarding the relation of fertility treatment with childhood cancer risk. A systematic literature search of several databases was conducted through April 2018 to identify relevant studies. Read More

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December 2018
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Uranium exposure increases spermatocytes metaphase apoptosis in rats: inhibitory effect of thymoquinone and N-acetylcysteine.

Gen Physiol Biophys 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Physiology, Department of Zoology, Faculty of Sciences, Assiut University, Assiut, Egypt.

Uranyl acetate (UA), a commercial stock from depleted uranium (DU), has a combined effect of chemical toxicity and mild radioactivity. Here, we investigated the potential antioxidant, antiapoptotic and cytoprotective effects of thymoquinone (TQ) and N-acetylcysteine (NAC) against UA-induced testicular damage in rats. UA reduced testicular superoxide dismutase (SOD) activity and nitric oxide (NO) and glutathione (GSH) levels relative to the control group. Read More

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December 2018

Multiple-Partner Fertility in the United States: A Demographic Portrait.

Authors:
Lindsay M Monte

Demography 2018 Dec 13. Epub 2018 Dec 13.

Fertility & Family Statistics Branch, U.S. Census Bureau, 4600 Silver Hill Road, Washington, DC, 20233, USA.

Multiple-partner fertility (MPF) occurs when a person has biological children with more than one partner. The 2014 Survey of Income and Program Participation (SIPP), a nationally representative panel study of individuals and households in the United States, is the first such survey to include a direct question about whether respondents are MPF parents. Understanding the prevalence of such families is important given the known socioeconomic correlates of MPF and the ramifications of entering MPF for both individuals and families. Read More

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December 2018

Lower follicular n-3 polyunsaturated fatty acid levels are associated with a better response to ovarian stimulation.

J Assist Reprod Genet 2018 Dec 13. Epub 2018 Dec 13.

Free Radicals and Oxidative Stress (FROS) Research Group of the Department of Physiology, Medicine and Nursing School, University of the Basque Country UPV/EHU, 48940, Leioa, Spain.

Objectives: To analyze in detail the fatty acid (FA) composition of follicular fluid (FF) from two-sized follicles at oocyte retrieval and to determine associations of the FAs from large follicles with the woman's age and the response to ovarian stimulation.

Design: Observational study.

Setting: University and fertility clinic. Read More

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December 2018
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Thyroid Hormone Deiodination and Action in the Gonads.

Authors:
Arturo Hernandez

Curr Opin Endocr Metab Res 2018 Oct 7;2:18-23. Epub 2018 Feb 7.

Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine, USA.

Alterations in thyroid hormone (TH) status during developmental or adult age are associated with abnormal gonadal development and function in human and animal models. In the developing testis, aberrant levels of TH action lead to disruptions in cell proliferation and differentiation, ultimately influencing testicular size, spermatogenesis, steroidogenesis and male fertility. Recent work is increasingly identifying the systems and signaling pathways in gonadal cells that are affected by TH, as well as delineating the major factors that determine TH signaling in gonadal tissue. Read More

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October 2018
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What makes people ready to conceive? Findings from the International Fertility Decision-Making Study.

Reprod Biomed Soc Online 2018 Aug 10;6:90-101. Epub 2018 Nov 10.

School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK.

This study investigated fertility decision-making in people currently trying to conceive, and examined whether factors that make people ready to conceive differ by gender and country. The study used data from the International Fertility Decision-Making Study, a cross-sectional study of 10,045 participants (1690 men and 8355 women) from 79 countries. Respondents were aged 18-50 years (mean 31. Read More

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Infertility patients' need and preferences for online peer support.

Reprod Biomed Soc Online 2018 Aug 15;6:80-89. Epub 2018 Nov 15.

Jewish General Hospital, Department of Psychiatry, Montreal, Quebec, Canada.

This study sought to determine the level of interest in online peer support among infertility patients, factors associated with such interest, and preferences for features of an online peer support network. A sample of 236 men and 283 women ( = 519) seeking fertility treatment were recruited from four clinics in Ontario and Quebec, Canada. Participants completed an anonymous online questionnaire assessing demographics, perceived stress and fertility characteristics, in addition to interest in and preferences for online infertility peer support. Read More

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August 2018
2 Reads

Live birth following laparoscopic fertility-sparing surgery for papillary thyroid carcinoma arising from mature ovarian cystic teratoma: A case report.

Mol Clin Oncol 2018 Dec 5;9(6):613-616. Epub 2018 Oct 5.

Department of Obstetrics and Gynecology, Hashimoto Municipal Hospital, Hashimoto, Wakayama 648-0005, Japan.

Papillary thyroid carcinoma arising from ovarian mature cystic teratoma is clinically rare. We herein present a case of live birth following two laparoscopic surgeries for papillary thyroid carcinoma arising in a mature ovarian cystic teratoma. A 30-year-old female patient, gravida 1 para 1, was treated by laparoscopic bilateral ovarian cystectomy for suspicion of bilateral mature cystic teratoma. Read More

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December 2018

Cancers among adolescents and young adults at one institution in Japan.

Oncol Lett 2018 Dec 1;16(6):7212-7222. Epub 2018 Oct 1.

Department of Medical Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

Adolescents and young adults (AYAs) with cancer often live long lives following treatment and face many life events. No detailed studies of cancers in AYAs have described the epidemiology, treatment outcome, and social status in Japan. The present study defined AYAs as those aged 15-29 years old based on the US National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program. Read More

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December 2018

27 years of prenatal diagnosis for Huntington disease in the United Kingdom.

Genet Med 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Purpose: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced.

Methods: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015. Read More

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December 2018
1 Read

Fresh-blood-free diet for rearing malaria mosquito vectors.

Sci Rep 2018 Dec 13;8(1):17807. Epub 2018 Dec 13.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisboa, Portugal.

Mosquito breeding depends on the supply of fresh vertebrate blood, a major bottleneck for large-scale production of Anopheles spp. Feeding alternatives to fresh blood are thus a priority for research, outdoor large-cage trials and control interventions. Several artificial meal compositions were tested and Anopheles oogenesis, egg laying and development into the next generation of adult mosquitoes were followed. Read More

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December 2018

Maternal Education, Fertility, and Child Survival in Comoros.

Int J Environ Res Public Health 2018 12 10;15(12). Epub 2018 Dec 10.

Department of Agricultural Economics and Extension, North-West University Mafikeng Campus, Mmabatho 2735, South Africa.

Reduction in child mortality is a demographic progress of significant socioeconomic development relevance in Africa. This paper analyzed the effect of maternal education and fertility on child survival in the Islands of Comoros. The 2012 Demographic and Health Survey (DHS) data were used. Read More

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December 2018

How to Measure Population Aging? The Answer Is Less than Obvious: A Review.

Gerontology 2018 Dec 13:1-9. Epub 2018 Dec 13.

Rockefeller University, New York, New York, USA.

Usually, population aging is measured to inform fiscal and social planning because it is considered to indicate the burden that an elderly population presents to the economic, social security, and health systems of a society. Measures of population aging are expected to indicate shifts in the distribution of individuals' attributes (e.g. Read More

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December 2018

The unintended effects of place based programs: Fertility and health effects of urban empowerment zones.

Authors:
Daniel Grossman

J Health Econ 2018 Nov 29;63:114-127. Epub 2018 Nov 29.

Department of Economics College of Business and Economics, West Virginia University, Morgantown, WV 26506-6025, United States. Electronic address:

Whether place-based welfare programs affect fertility and health outcomes is an understudied question. I estimate the health impacts of the Empowerment Zone (EZ) program-a federal program that gave sizeable grants and tax breaks to certain high-poverty census tracts in selected cities. Using difference-in-differences methods, I find that the EZ program decreased fertility rates by 11 percent and improved birth outcomes. Read More

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November 2018

Effect of cryopreservation techniques on proliferation and apoptosis of cultured equine ovarian tissue.

Theriogenology 2018 Dec 1;126:88-94. Epub 2018 Dec 1.

Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, lllinois, USA. Electronic address:

Preservation of cellular integrity and its mechanisms after ovarian tissue cryopreservation (OTC) and in vitro culture (IVC) procedures are crucial aspects for the success of preservation and recovery of female fertility. This study aimed to evaluate the effects of two cryopreservation methods (slow-freezing, SF, and vitrification, VIT) on the equine ovarian tissue after 1, 3, and 7 days of IVC by assessing: (i) preantral follicle morphology and distribution of follicle classes; (ii) protein expression of markers of cell proliferation for EGFR and Ki-67; (iii) markers of apoptosis for Bax and Bcl-2; and (iv) DNA fragmentation. Percentages of normal primordial follicles were similar (P > 0. Read More

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December 2018
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Video-assisted ablation of pilonidal sinus (VAAPS) versus sinusectomy for treatment of chronic pilonidal sinus disease: a comparative study.

Updates Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.

Since its first description in 1883, different treatments for pilonidal sinus disease have been proposed, but we are still far from the identification of an ideal approach. The objective of this study is to determine if video-assisted ablation of pilonidal sinus (VAAPS) could be considered superior/non-inferior to standard sinusectomy for treatment of pilonidal sinus disease. After applying propensity score analysis, data from 40 patients who underwent sinusectomy and 40 patients who underwent VAAPS, from March 2011 to August 2013, were collected. Read More

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December 2018