17,791 results match your criteria Femoral Neck Fracture

Quantitating Age-Related BMD Textural Variation from DXA Region-Free-Analysis: A Study of Hip Fracture Prediction in Three Cohorts.

J Bone Miner Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Oncology and Metabolism, The University of Sheffield, Sheffield, S10 2RX, U.K.

The risk of osteoporotic fracture is inversely related to bone mineral density (BMD), but how spatial BMD pattern influences fracture risk remains incompletely understood. This study used a pixel-level spatio-temporal atlas of proximal femoral BMD in 13,338 white European women (age 20 to 97 years) to quantitate age-related texture variation in BMD maps and generate a 'reference' map of bone ageing. We introduce a new index, called Densitometric Bone Age (DBA), as the age at which an individual site-specific BMD map (the proximal femur is studied here) best matches the median ageing trajectory at that site in terms of the root mean squared error (RMSE). Read More

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Primary Hemiarthroplasty for the Treatment of Basicervical Femoral Neck Fractures.

Cureus 2022 May 22;14(5):e25210. Epub 2022 May 22.

Orthopaedic Surgery, Wright State University, Dayton, USA.

Purpose Basicervical femoral neck fractures are uncommon injuries that occur at the extracapsular base of the femoral neck at its transition with the intertrochanteric line. Controversy remains in the orthopedic literature as to the optimal method of treatment for this fracture type given the inherent instability and greater rate of implant failure with traditional fixation constructs. The purpose of this study is to quantify the incidence and preferred treatment methods of basicervical hip fractures at a single, regional, Level 1 trauma center and to identify differences in postoperative complications between treatment options. Read More

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Dipeptidyl Peptidase 3 Activity as a Promising Biomarker of Bone Fragility in Postmenopausal Women.

Molecules 2022 Jun 19;27(12). Epub 2022 Jun 19.

Unit of Metabolic Bone and Thyroid Disorders, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

The dipeptidyl peptidase 3 () is a ubiquitous zinc-dependent aminopeptidase, participating in the activation or degradation of signaling peptides and in the Keap1-Nrf2 antioxidant pathway. The absence of in the knockout mouse model causes increased osteoclast activity, altered osteogenic function, sustained oxidative stress in the bone tissue, and bone loss. We aimed to assess the association of activity with bone fragility in postmenopausal osteoporosis and the impact of denosumab on enzymatic activity. Read More

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Avascular Necrosis of Femoral Head-Overview and Current State of the Art.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland.

Avascular necrosis (AVN) of the femoral head is caused by disruption of the blood supply to the proximal femur. The alterations in the blood supply may occur following a traumatic event or result from a non-traumatic cause. Femoral neck fracture and hip dislocation and associated surgical procedures, corticosteroid therapy, and alcohol abuse frequently lead to AVN development. Read More

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Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes.

Biomedicines 2022 Jun 8;10(6). Epub 2022 Jun 8.

BG Trauma Center Bergmannstrost, 06112 Halle (Saale), Germany.

Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators. Hip chondrocytes from patients with OA or femoral neck fracture (non-OA) were stimulated with IL-1β, TNF, forskolin and opioid peptides. Read More

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Risk Stratification and Pain Outcomes Following Revision Total Hip Arthroplasty for Adverse Local Tissue Reactions.

J Arthroplasty 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA; Department of Bioengineering, and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA. Electronic address:

Introduction: Revision total hip arthroplasty (THA) for adverse local tissue reactions (ALTRs) secondary to head-neck taper corrosion is associated with a high complication rate. Diagnosis of ALTR is based on risk stratification using the patient's history and examination, implant risk, serum metal ion levels, and imaging. The purpose of this study was to determine if stratification using similar risk factors is predictive of outcomes following revision THA for metal-on-polyethylene (MoP) ALTR. Read More

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A quantitative study of bone defects in displaced femoral neck fractures based on virtual reduction techniques.

Comput Methods Programs Biomed 2022 Jun 16;222:106958. Epub 2022 Jun 16.

Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address:

Background: Bone defects in femoral neck fractures are strongly associated with the prognosis after internal fixation. However, qualitative analysis of bone defects in femoral neck fractures has already been performed, quantitative studies have not been reported. In this study, we aimed to systematically analyse the morphological characteristics of bone defects in patients with femoral neck fractures using computed tomography (CT) images combined with computer image analysis techniques. Read More

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Incidence and treatment of intracapsular femoral neck fractures in Germany.

Arch Orthop Trauma Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Trauma Surgery, University Medical Centre Regensburg, Franz‑Josef‑Strauss Allee 11, 93053, Regensburg, Germany.

Introduction: Intracapsular femoral neck fractures are one of the most common fractures in Germany. Nevertheless, the epidemiology and treatment modalities are not described comprehensively. For this reason, this study highlights the epidemiology of femoral neck fractures in different age groups and summarizes treatment strategies within the period from 2009 to 2019 based on nationwide data. Read More

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[Development and clinical application of an adjustable digital cannulated nail guide based on Mimics software].

Zhongguo Gu Shang 2022 Jun;35(6):520-6

Division of Sports Medicine and Adult Reconstructive Surgery, the Affiliated Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210000, Jiangsu, China.

Objective: To evaluate effectiveness of self-designed adjustable cannulated screw guide, and to provide an effective auxiliary tool for inverted triangular arrangement of compression cannulated screws in clinical treatment for transcervical femoral neck fractures.

Methods: The sketch of instrument was drawn with Solidworks software, and physical product was obtained after production. The data were obtained by Mimics software. Read More

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Relationship of pathogenic mutations and responses to zoledronic acid in a cohort of osteogenesis imperfecta children.

J Clin Endocrinol Metab 2022 Jun 21. Epub 2022 Jun 21.

Department of Endocrinology, Key Laboratory of Endocrinology of National Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Context: Osteogenesis imperfecta (OI) is a rare, heterogeneous genetic disorder characterized by bone fragility and recurrent fractures. Bisphosphonates (BPs) are the most commonly used medications for OI, but their efficacy has great variability.

Objective: We investigate the relationship of pathogenic gene mutations and responses to zoledronic acid (ZOL) in a large cohort of OI children. Read More

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Are there really specific risk factors for heterotopic ossifications? A case report of 'non-risk factor' after total hip replacement.

J Int Med Res 2022 Jun;50(6):3000605221095225

Department of Adult Orthopaedics, District Hospital of Orthopaedics and Trauma Surgery, Piekary Śląskie, Poland.

Femoral neck fractures are one of the most common fractures in the elderly population. Due to frequent complications of the fixation of these fractures, patients are more and more often eligible for hip replacement surgery. One of the most frequently mentioned postoperative complication is the formation of heterotopic ossification. Read More

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A localization method for guide pin insertion points in the treatment of femoral neck fracture with closed reduction and percutaneous cannulated screw fixation.

Ann Transl Med 2022 May;10(10):568

Department of Trauma Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Background: Closed reduction and percutaneous cannulated screw fixation is the preferred surgical method for treating femoral neck fractures in elderly patients under 70 years old. The key to the operation is the precise insertion of the guide pin after the successful reduction. However, there is no universally accepted standard for the localization of the guide pin insertion point. Read More

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Causes of revision after total hip arthroplasty in an orthopedics and traumatology regional center.

Med Pharm Rep 2022 Apr 28;95(2):179-184. Epub 2022 Apr 28.

Department of Orthopedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background And Aim: Despite the great success of primary total hip arthroplasty (THA), the number of revisions has significantly increased over the past years. The objectives of the study were to investigate the main causes that lead to revision of THA, the time interval between primary THA and revision, and the results of the revision surgery. We also assessed whether there was any correlation between the patients' age, BMI, diagnosis for primary THA and the cause of failure. Read More

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Functional and Radiological Outcomes of Unstable Proximal Femur Fractures Fixed With Anatomical Proximal Locking Compression Plate.

Cureus 2022 May 11;14(5):e24903. Epub 2022 May 11.

Orthopedics, Cardiff and Vale University Health Board, Cardiff, GBR.

Introduction Peritrochanteric fractures are the most frequent fractures of the proximal femur that accounts for nearly half of all proximal femur fractures. They are a major cause of disability in the elderly. The aim is to study the functional and radiological outcome of unstable proximal femur fractures fixed with proximal femur locking compression plate (PF-LCP) and its complications. Read More

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Higher BMI and lower femoral neck strength in males with type 2 diabetes mellitus and normal bone mineral density.

Am J Med Sci 2022 Jun 16. Epub 2022 Jun 16.

Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China. Electronic address:

Background: Type 2 diabetes mellitus (T2DM) and osteoporosis are two age-associated diseases. Body mass index (BMI) is positively associated with osteoporosis or osteopenia in T2DM population. Bone mineral density does not necessarily reflect the alterations in bone microarchitecture. Read More

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A case of fatal fulminant fat embolism syndrome following multiple fractures resulting from a fall.

J Forensic Sci 2022 Jun 17. Epub 2022 Jun 17.

Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Fat embolism syndrome is a life-threatening condition in which fatty substances enter the circulation and cause respiratory distress and neurological symptoms. It can occur following trauma and severe fat embolism occurring soon after trauma is known as fulminant fat embolism syndrome. Although fat staining of the lungs is helpful for diagnosing fat embolism syndrome at autopsy, clinical and other information is needed to determine the relationship between cause of death and the syndrome. Read More

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[Midterm effectiveness of percutaneous compression plate for femoral neck fractures in young and middle-aged patients].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Jun;36(6):708-713

Department of Orthopedics, the First Affiliated Hospital, Soochow University, Suzhou Jiangsu, 215008, P. R. China.

Objective: To analyze midterm effectiveness of percutaneous compression plate (PCCP) for femoral neck fractures in young and middle-aged patients.

Methods: The clinical data of 173 young and middle-aged patients with femoral neck fractures who met the selection criteria and were treated with PCCP internal fixation between January 2011 and March 2019 were retrospectively analyzed. Among them, there were 102 males and 71 females; the age ranged from 18 to 59 years, with an average age of 44. Read More

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Prevalence and correlative factors of hyperhomocysteinemia in elderly patients with femoral neck fracture: A cross-sectional study.

J Clin Lab Anal 2022 Jun 17:e24563. Epub 2022 Jun 17.

Department of Orthopedic Surgery, Ningbo No.6 Hospital, Ningbo City, China.

Aims: The occurrence of hyperhomocysteinemia (HHcy) in elderly patients with femoral neck fracture (FNF) draws little attention from surgeons preoperatively. The aim of our study was to determine the prevalence and correlative factors of HHcy in elderly patients (≥65 years) with FNF prior to surgery.

Methods: We retrospectively investigated 286 elderly FNF patients aged 65-98 years admitted to our institution from September 2020 to September 2021. Read More

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Incidence and Risk Factors for Surgical Site Infection after Femoral Neck Fracture Surgery: An Observational Cohort Study of 2218 Patients.

Biomed Res Int 2022 6;2022:5456616. Epub 2022 Jun 6.

Department of Orthopaedic Surgery, The 3rd Hospital of Hebei Medical University, Shijiazhuang, 050051 Hebei, China.

Background: Surgical site infection (SSI) was a formidable challenge for surgical management of femoral neck fractures; however, there was a lack of studies with comprehensive variables. We conducted this study to investigate the incidence and risk factors of SSI in elderly patients with femoral neck fractures.

Methods: This was a retrospective study of patients who presented with femoral neck fractures and underwent surgery in our institution between January 2016 and April 2020. Read More

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Treatment Failure in Femoral Neck Fractures in Adults Less Than 50 Years of Age: Analysis of 492 Patients Repaired at 26 North American Trauma Centers.

J Orthop Trauma 2022 06;36(6):271-279

Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA.

Objectives: To assess the operative results of femoral neck fractures (FNFs) in young adults in a large multicenter series, specifically focusing on risk factors for treatment failure.

Design: Large multicenter retrospective cohort series.

Setting: Twenty-six North American Level 1 trauma centers. Read More

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Total hip arthroplasty for treatment of femoral neck fracture due to hypophosphatemic osteomalacia: a retrospective case series with mean follow-up of five years.

Int Orthop 2022 Jun 14. Epub 2022 Jun 14.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: To retrospectively characterize the clinical characteristics and efficacy of total hip arthroplasty and the important factors needing attention in hypophosphatemic osteomalacia (HO) patients with hip involvement.

Patients And Methods: We performed a review of seven patients (two women and five men) referred to our clinic with a final diagnosis of HO who received total hip arthroplasty between 2010 and 2018. Five patients (Group 1) received proper medical management with or without aetiologic therapy, while the other two patients (Group 2) did not receive due to misdiagnosis. Read More

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Pericapsular nerve group block for hip fracture is feasible, safe and effective in the emergency department: A prospective observational comparative cohort study.

Emerg Med Australas 2022 Jun 14. Epub 2022 Jun 14.

Department of Emergency Medicine, Gold Coast University Hospital, Gold Coast, Queensland, Australia.

Objectives: The pericapsular nerve group (PENG) block was first described for analgesia of hip fracture in 2018. We hypothesised that the PENG block is safe and effective for patients with hip fracture when provided by emergency physicians and trainees in the ED.

Methods: This was an observational study of routine care. Read More

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Total Hip Arthroplasty Leads to Better Results After Low-Energy Displaced Femoral Neck Fracture in Patients Aged 55 to 70 Years: A Randomized Controlled Multicenter Trial Comparing Internal Fixation and Total Hip Arthroplasty.

J Bone Joint Surg Am 2022 May 31. Epub 2022 May 31.

Department of Orthopaedic Surgery, Akershus University Hospital, Lørenskog, Norway.

Background: The optimal treatment of displaced femoral neck fractures in patients 55 to 70 years old remains controversial. The aim of the present study was to assess the effect of closed reduction and internal fixation with cannulated screws (IF) compared with total hip arthroplasty (THA) on hip pain and function, with use of data for outcome measures, complications, and reoperations.

Methods: This multicenter randomized controlled trial included all patients 55 to 70 years old who presented with a low-energy displaced femoral neck fracture between December 2013 and December 2018. Read More

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Rate of conversion to secondary arthroplasty after femoral neck fractures in 796 younger patients treated with internal fixation: a Swedish national register-based study.

Acta Orthop 2022 Jun 14;93:547-553. Epub 2022 Jun 14.

Department of Orthopaedics, Lund University, Skåne University Hospital, Malmö, Sweden; Swedish Fracture Register, Gothenburg, Sweden; Swedish Arthroplasty Register, Gothenburg, Sweden.

Background And Purpose: In younger patients with a femoral neck fracture (FNF), internal fixation is the recommended treatment regardless of displacement. Healing complications are often treated with arthroplasty. We determined the rate of conversion to arthroplasty up to 5 years after fixation of either undisplaced FNFs (uFNFs) or displaced FNFs (dFNFs). Read More

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Hip fractures re-operation compared with death at two year in elderly patients: lowest risk of revision with dual mobility total hip arthroplasty than with bipolar hemiarthroplasty or internal fixation of Garden I and II.

Int Orthop 2022 Jun 14. Epub 2022 Jun 14.

Orthopedic Department, EpiCURA Baudour Hornu Ath Hospital, Hainaut, Belgium.

Purpose: This study determined at two year follow-up the lifetime risk of re-operation for elderly patients with hip fractures undergoing internal fixation, dual mobility total hip arthroplasty, or bipolar hemiarthroplasty, using death of the patient as a competing risk.

Materials And Methods: With the hypothesis that arthroplasties may have less complications without increasing mortality even for Garden I and Garden II fractures, we retrospectively reviewed 317 hips with femoral neck fractures operated between January 2015 and August 2019. The mean age at time of surgical intervention was 82. Read More

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Acetabular cartilage abnormalities in elderly patients with femoral neck fractures.

SICOT J 2022 14;8:24. Epub 2022 Jun 14.

Department of Orthopaedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Introduction: Both hemiarthroplasty (HA) and total hip arthroplasty (THA) are widely accepted surgical procedures for hip replacement following displaced femoral neck fractures. However, in cases involving an intact joint line before surgery, the choice between HA and THA remains debatable. This study investigated the prevalence of acetabular cartilage and labral abnormalities in elderly patients with femoral neck fractures. Read More

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Interdisciplinary Model-Informed Drug Development for Extending Duration of Elagolix Treatment in Patients with Uterine Fibroids.

Br J Clin Pharmacol 2022 Jun 13. Epub 2022 Jun 13.

Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, IL, United States.

Aim: Elagolix, a gonadotropin-releasing hormone receptor antagonist, was recently approved for heavy menstrual bleeding associated with uterine fibroids (UF, Oriahnn™) at a dose of 300 mg twice daily (BID) in combination with add-back therapy (estradiol 1 mg/norethindrone acetate 0.5 mg [E2/NETA] once daily) for 24 months use. The limited duration of treatment is related to elagolix dose- and duration-dependent decrease in estrogen that is mechanistically linked to changes in bone mineral density (BMD). Read More

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Antegrade insertion of a retrograde intramedullary femoral nail for treatment of a subtrochanteric pathological femoral shaft fracture in a patient with pre-existing coxa vara.

Radiol Case Rep 2022 Aug 8;17(8):2815-2819. Epub 2022 Jun 8.

Department of Trauma and Orthopaedics, Diana Princess of Wales Hospital, DN33 2BA, Grimsby, United Kingdom.

We report the unorthodox use of a retrograde intramedullary nail via antegrade technique for the treatment of a subtrochanteric pathological femur fracture in the presence of significant coxa vara. No similar use has been documented previously in literature. A standard approach to the proximal right femur was performed and standard antegrade technique used to introduce a guide wire into the proximal femur after which the femoral shaft was reamed. Read More

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High-Intensity Exercise and Geometric Indices of Hip Bone Strength in Postmenopausal Women on or off Bone Medication: The MEDEX-OP Randomised Controlled Trial.

Calcif Tissue Int 2022 Jun 12. Epub 2022 Jun 12.

Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, QLD, 4222, Australia.

To compare the effects of high-intensity resistance and impact training (HiRIT) to low-intensity, Pilates-based exercise (LiPBE) on proximal femur geometry and explore the influence of antiresorptive medication on those effects. Postmenopausal women with low bone mass, on or off antiresorptive bone medications were randomly allocated, stratified on medication intake, to eight months of twice-weekly, supervised HiRIT (Onero™) or LiPBE (Buff Bones®). 3D hip software was used to analyse proximal femur DXA scans. Read More

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Biomechanical comparison of the femoral neck system versus InterTan nail and three cannulated screws for unstable Pauwels type III femoral neck fracture.

Biomed Eng Online 2022 Jun 10;21(1):34. Epub 2022 Jun 10.

Department of Orthopaedic, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.

Background: There are a variety of internal fixation methods for unstable femoral neck fractures (FNFs), but the best method is still unclear. Femoral neck system (FNS) is a dynamic angular stabilization system with cross screws, and is a new internal fixation implant designed for minimally invasive fixation of FNFs. In this study, we conducted a biomechanical comparison of FNS, InterTan nail and three cannulated screws for the treatment of Pauwels III FNFs and investigate the biomechanical properties of FNS. Read More

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