1,201 results match your criteria Femoral Mononeuropathy

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.

Nat Commun 2021 06 2;12(1):3285. Epub 2021 Jun 2.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

In peripheral nerves, Schwann cells form myelin and provide trophic support to axons. We previously showed that the mitochondrial protein prohibitin 2 can localize to the axon-Schwann-cell interface and is required for developmental myelination. Whether the homologous protein prohibitin 1 has a similar role, and whether prohibitins also play important roles in Schwann cell mitochondria is unknown. Read More

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Treatment of meralgia paresthetica (Lateral Femoral Cutaneous Neuropathy): A meta-analysis of ultrasound-guided injection versus surgery.

Eur J Radiol 2021 Jun 26;139:109736. Epub 2021 Apr 26.

Department of Health Sciences (DISSAL). University of Genoa, Genoa, Italy. Electronic address:

Purpose: To compare ultrasound (US)-guided injections and surgery for the treatment of meralgia paresthetica (lateral femoral cutaneous neuropathy).

Methods: Two reviewers, independently, up to 10 October 2020 retrieved Studies that assessed the outcome of US-guided injections and surgery for the treatment of meralgia paresthetica from major medical libraries. Predefined inclusion and exclusion criteria were adopted. Read More

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The Effect of Lutein on Ischemia-reperfusion-induced Vasculitic Neuropathic Pain and Neuropathy in Rats.

In Vivo 2021 May-Jun;35(3):1537-1543

Department of Neurosurgery, Adatip Hospital, Istanbul, Turkey

Background/aim: Neuropathic pain and neuropathy is commonly seen after ischemia-reperfusion injuries. Our aim was to evaluate the effect of lutein on ischemia-reperfusion (I/R)-induced vasculitic neuropathic pain and neuropathy in rats.

Materials And Methods: An hour before anesthesia, 6 Albino Wistar male rats with I/R were orally administered with 1 mg/kg lutein (LIR group). Read More

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January 2021

Popliteal Entrapment Syndrome as a Cause of Chronic Lower Extremity Pain in a 16-Year Old.

Cureus 2021 Mar 5;13(3):e13723. Epub 2021 Mar 5.

Internal Medicine-Pediatrics, Icahn School of Medicine at Mount Sinai, New York, USA.

Popliteal entrapment syndrome is an uncommon cause of intermittent claudication in young patients lacking atherosclerotic risk factors. ZS is a 16-year-old cisgender female with type 1 diabetes complicated by microalbuminuria, obesity (body mass index (BMI) = 45.86 kg/m²), and a history of perinatal stroke with residual right-sided hemiparesis, who presented with six months of worsening bilateral, exertional lower extremity pain. Read More

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Guided growth in the correction of knee deformity in patients with congenital insensitivity to pain.

J Orthop Surg Res 2021 Mar 11;16(1):184. Epub 2021 Mar 11.

Joint Reconstruction Research Center, Department of Orthopedics, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran, 1419733141, Iran.

Background: Orthopedic manifestations of congenital insensitivity to pain (CIP) can be devastating if left untreated. Knee deformities are common in patients with CIP and might lead to joint destruction and loss of walking ability. The purpose of the present study was to report the results and complications of guided growth procedures around the knee in patients with CIP. Read More

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AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy.

Gene Ther 2021 Mar 10. Epub 2021 Mar 10.

Neuroscience Department, The Cyprus Institute of Neurology and Genetics and Cyprus School of Molecular Medicine, Nicosia, Cyprus.

Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32), cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We developed a gene therapy approach for CMT1X using an AAV9 vector to deliver the GJB1/Cx32 gene under the myelin protein zero (Mpz) promoter for targeted expression in Schwann cells. Lumbar intrathecal injection of the AAV9-Mpz. Read More

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Meralgia paresthetica attributable to surgery in the park-bench position.

J Nippon Med Sch 2021 Mar 9. Epub 2021 Mar 9.

Department of Neurosurgery, Nippon Medical School.

Objective: Meralgia paresthetica (MP) is an entrapment neuropathy of the lateral femoral cutaneous nerve (LFCN). We report a rare MP complication after microvascular decompression (MVD) surgery in the park-bench position in a patient with hemi-facial spasm.

Case: The patient was a 46-year-old female (height: 155 cm, weight: 42 kg). Read More

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Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population.

BMC Musculoskelet Disord 2021 Mar 10;22(1):261. Epub 2021 Mar 10.

Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.

Background: Altered circulating levels and genetic variation of B-type natriuretic peptide (BNP), has been associated with lower bone mineral density (BMD) values and incidence of osteoporosis in peritoneal dialysis patients, renal transplant recipients, and postmenopausal women. The potential relationship of circulating BNP with osteoporosis in patients with type 2 diabetes mellitus (T2DM), however, has not yet been studied.

Methods: Circulating BNP levels were measured in 314 patients with T2DM, and participants were divided into normal BMD group (n = 73), osteopenia group (n = 120), and osteoporosis group (n = 121). Read More

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Traditional and non-traditional risk factors for peripheral artery disease development/progression in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study.

Cardiovasc Diabetol 2021 02 27;20(1):54. Epub 2021 Feb 27.

Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rua Croton, 72, Jacarepagua, Rio de Janeiro, RJ, CEP: 22750-240, Brazil.

Background: The prognostic importance of non-traditional risk factors for peripheral artery disease (PAD) development/progression is scarcely studied in diabetes. We investigated if carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) added prognostic information beyond traditional cardiovascular risk markers for PAD outcomes.

Methods: Ankle-brachial index (ABI) was measured at baseline and after a median of 91 months of follow-up in 681 individuals with type 2 diabetes. Read More

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February 2021

Lateral femoral cutaneous neuropathy caused by prone positioning to treat COVID-19-associated acute respiratory distress syndrome.

Lan Zhou Peter Siao

Muscle Nerve 2021 06 27;63(6):E50-E52. Epub 2021 Mar 27.

Department of Neurology, Boston Medical Center, Boston, Massachusetts, USA.

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Medical and surgical treatment of meralgia paresthetica.

Pain Manag 2021 Apr 11;11(4):389-393. Epub 2021 Feb 11.

Department of Orthopedics & Traumatology, University of Health Sciences, Derince Training & Research Hospital, Kocaeli, Turkey.

Meralgia paresthetica (MP) is a painful mononeuropathy that causes paresthesia, tingling, stinging or a burning sensation in the thigh's anterolateral part due to the entrapment of the lateral femoral cutaneous nerve under the inguinal ligament. The treatment options for MP include conservative or interventional management and must follow an algorithm. The objective is to eliminate the underlying cause if known. Read More

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[Meralgia paresthetica after prolonged prone position at the intensive care unit among COVID-19 patients. A case report].

Lakartidningen 2021 02 3;118. Epub 2021 Feb 3.


Meralgia paresthetica (MP) is an entrapment syndrome that may cause loss of sensation, numbness, paresthesia and pain within the distribution of the lateral femoral cutaneous nerve. This condition is more common in persons with diabetes mellitus, obesity and in old age. MP has previously been described in patients that have undergone surgery in the prone position (PP) and in a case report of a patient with ARDS (Acute Respiratory Distress Syndrome) who was cared for in the intensive care unit (ICU). Read More

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February 2021

Spontaneous iliacus haematoma with femoral nerve palsy: an appeal to involve surgical teams early.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Orthopaedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.

We report the case of a 68-year-old man who was placed on heparin as bridge therapy and subsequently developed an iliacus haematoma with associated femoral nerve palsy. His team involved the orthopaedic surgery team in delayed fashion after his symptom onset. Due to his active medical conditions, he did not undergo surgical decompression of his haematoma until late into his hospital course. Read More

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January 2021

Post-Surgical Inflammatory Neuropathy: An Underappreciated but Critical and Treatable Cause of Postoperative Neuropathy.

Cureus 2020 Dec 5;12(12):e11927. Epub 2020 Dec 5.

Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, USA.

The diagnosis and management of postoperative nerve injury can be a challenging and frustrating proposition for the patient, surgeon, and anesthesia provider. Unfortunately, in many cases, the true etiology is never elucidated and the injury is ascribed to positioning or a nerve block with "expectant management" being the order of the day, which can result in persistent disability for the patient. However, there is a rare subset of disorders affecting the nervous system that can masquerade as a peripheral nerve injury that warrants further investigation of risk factors and co-morbidities when other common causes of nerve injury are ruled out. Read More

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December 2020

Femoral nerve compression caused by a hibernoma in the right thigh: a case report and literature review.

BMC Surg 2021 Jan 7;21(1):30. Epub 2021 Jan 7.

Department of Hand Surgery, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin, China.

Background: A hibernoma, also known as a brown fat tumor, is a rare benign soft tissue tumor, which originates from brown adipose tissue remaining in the fetus after the gestational period. It is often detected in adult men, presenting as a painless slow-growing mass. Hibernomas of the thigh have been reported; however, motor and sensory disorders caused by the tumors compressing the femoral nerve have not been reported. Read More

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January 2021

Case report: Hybrid approach in the management of a complete persistent sciatic artery aneurysm.

Int J Surg Case Rep 2020 19;77:787-790. Epub 2020 Nov 19.

Department of Endovascular & Vascular Surgery, Geisinger Medical Center, Danville, PA, United States.

Introduction: Persistent sciatic artery (PSA) is a rare embryological vascular anomaly with a prevalence between 0.025-0.06%. Read More

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November 2020

Novel Reconstruction of Complex Central Venous Occlusion Using Supraclavicular Stent Graft in Hemodialysis Patients.

Ann Vasc Surg 2021 May 26;73:185-196. Epub 2020 Dec 26.

DFW Vascular Group, Dallas, TX; Surgery, Methodist Dallas Medical Center, Dallas, TX; TCU School of Medicine, Ft. Worth, TX. Electronic address:

Background: Subclavian vein and brachiocephalic vein occlusions are challenging problems in dialysis patients with ipsilateral upper extremity (UE) vascular access or in need of one. HeRO grafts (Hemodialysis Reliable Outflow, Merit Medical Systems, Inc, South Jordan, UT) have been used to manage such occlusions but patients with chronic hypotension treated with HeRO graft may have threatened patency. We describe an alternative technique using a supraclavicular stent graft to reconstruct the venous outflow, evaluate outcomes of this procedure, and discuss its role in complex hemodialysis patients. Read More

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Meralgia paraesthetica in intensive care unit survivors of COVID-19.

Anaesthesia 2021 05 22;76(5):712-713. Epub 2020 Dec 22.

Glasgow Royal Infirmary, Glasgow, UK.

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Iliopsoas hematoma presenting with sudden knee extensor weakness: A case report.

Medicine (Baltimore) 2020 Dec;99(50):e23497

Department of Physical Medicine and Rehabilitation, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Rationale: Hematoma of the iliopsoas muscle is a rare condition. Prolonged pressure conditions due to hematoma of the femoral nerve can cause severe pain in the affected groin, hip, and thigh, and quadriceps weakness. We report a rare case of a spontaneous iliopsoas muscle hematoma that caused sudden femoral neuropathy. Read More

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December 2020

Idiopathic Lumbosacral Neuropathy Syndrome: Case Report.

Sisli Etfal Hastan Tip Bul 2020 24;54(3):384-387. Epub 2020 Aug 24.

Department of Physical Medicine and Rehabilitation, University of Health Sciences Turkey, Sisli Hamidiye Etfal Teaching and Resarch Hospital, Istanbul Turkey.

Idiopathic lumbosacral plexitis or lumbosacral radiculoplexus neuropathy is a disease characterized by nerve damage in lumbar and/or sacral plexus without trauma, mass effect or diabetic complications. A 47-year-old male patient with right groin pain and loss of right leg muscle strength is presented in this case report. Neuropathy was detected in the L4 nerve root by electromyography and magnetic resonance neurrographic imaging. Read More

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Comments on the Role of Ultrasound-Guided Injection in the Management of Meralgia Paresthetica.

Pain Physician 2020 11;23(6):E731-E732

Department of Anaesthesiology, Sanjay Gan¬dhi Post Graduate Institute of Medical Sciences, Lucknow,India.

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November 2020

Peripheral Nerve Stimulation: A New Treatment for Meralgia Paresthetica.

Pain Med 2021 02;22(1):213-216

Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Background: Meralgia paresthetica is a condition caused by entrapment of the lateral femoral cutaneous nerve that leads to paresthesia along the anterolateral portion of the thigh. Because of advancements in neuromodulation, peripheral nerve stimulation (PNS) has been considered a new treatment option for meralgia paresthetica. Newer PNS technology targets peripheral nerves directly yet in a minimally invasive manner. Read More

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February 2021

Severe Postpartum Femoral Neuropathy: A Case Series.

J Obstet Gynaecol Can 2021 May 2;43(5):603-606. Epub 2020 Sep 2.

Discipline of Obstetrics & Gynecology, Memorial University of Newfoundland, St. John's, NL.

Background: Femoral neuropathy is a rare complication of vaginal delivery that is often under-reported. It is marked by weakness and sensory loss in the lower limbs. This report presents 3 cases to outline possible prevention strategies, as well as to describe the process of diagnosis, management, and recovery for this injury. Read More

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Femoral intraneural ganglion cyst: the first confirmed case report.

Br J Neurosurg 2020 Nov 5:1-3. Epub 2020 Nov 5.

Nerve and Plexus Surgery Program, Division of Neurosurgery, University of Buenos Aires School of Medicine, Buenos Aires, Argentina.

Background: Ganglion cysts affecting nerve are rare causes of neuropathy. The formation of intraneural ganglion cysts, once controversial, has recently been clarified. We describe the first modern description of a femoral intraneural ganglion cyst at the hip region. Read More

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November 2020

Extended pulsed radiofrequency as a part of multimodal pain management in a refractory case of Bernhardt-Roth syndrome.

BMJ Case Rep 2020 Nov 3;13(11). Epub 2020 Nov 3.

Burns and Plastic Surgey, AIIMS Rishikesh, Rishikesh, Uttarakhand, India.

Bernhardt-Roth syndrome (BRS) is a neurological condition characterised by pain, burning or numbness in anterolateral thigh due to entrapment of the lateral femoral cutaneous nerve (LFCN). The possible aetiologies can be mechanical, iatrogenic, neuropathic or idiopathic. After consent for possible publication, we are discussing a case of pain management in a 38-year-old patient with BRS secondary to diabetes. Read More

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November 2020

Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury.

J Vis Exp 2020 10 6(164). Epub 2020 Oct 6.

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology; Austrian Cluster for Tissue Regeneration;

Peripheral and central nerve injuries are mostly studied in rodents, especially rats, given the fact that these animal models are both cost-effective and a lot of comparative data has been published in the literature. This includes a multitude of assessment methods to study functional recovery following nerve injury and repair. Besides evaluation of nerve regeneration by means of histology, electrophysiology, and other in vivo and in vitro assessment techniques, functional recovery is the most important criterion to determine the degree of neural regeneration. Read More

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October 2020

Cryoanalgesia of the anterior femoral cutaneous nerve (AFCN) for the treatment of neuropathy-mediated anterior thigh pain: anatomy and technical description.

Skeletal Radiol 2021 Jun 22;50(6):1227-1236. Epub 2020 Oct 22.

Division of Musculoskeletal Radiology, Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA.

Objective: To describe and illustrate the magnetic resonance imaging (MRI) anatomy of the anterior femoral cutaneous nerve (AFCN) and a new technique for cryoanalgesia of the AFCN for long-term analgesic treatment of recalcitrant AFCN-mediated neuropathic pain.

Materials And Methods: Using a procedural high-resolution MRI technique, we describe the MRI anatomy of the AFCN. Three patients (mean age, 48 years; range, 41-67 years) with selective nerve block-verified recalcitrant AFCN-mediated anterior thigh pain were enrolled to undergo cryoanalgesia of the AFCN. Read More

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Lessons from an ICU recovery clinic: two cases of meralgia paresthetica after prone positioning to treat COVID-19-associated ARDS and modification of unit practices.

Crit Care 2020 09 27;24(1):580. Epub 2020 Sep 27.

Division of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California San Diego, San Diego, CA, USA.

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September 2020

Clinical and radiological outcomes of chronic severe slipped capital femoral epiphysis patients treated by surgical dislocation and modified Dunn osteotomy: Case series.

Jt Dis Relat Surg 2020 ;31(3):599-604

İzmir SBÜ Tepecik Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği 35170 Yenişehir, Konak, İzmir, Türkiye.

Objectives: This study aims to evaluate the clinical and radiological outcomes of patients with chronic severe slipped capital femoral epiphysis (SCFE) treated by surgical dislocation and modified Dunn osteotomy (MDO).

Patients And Methods: This retrospective study, conducted between January 2010 and December 2017, included nine patients (8 males, 1 female; mean age 12.6 years; range, 7 to 16 years) with nine hips. Read More

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February 2021

The persistent sciatic artery: Report of ten cases.

J Med Vasc 2020 Sep 22;45(5):241-247. Epub 2020 Jul 22.

Vascular surgery department, Mohammed V University, Rabat, Morocco.

Objective: The persistent sciatic artery (PSA) is a rare congenital anomaly with a high rate of aneurysm formation, occlusion and stenosis. It may lead to severe complications including thrombosis, distal embolisation, or aneurysm rupture. We reported herein our experience in the management of PSA and its complications, and discuss the therapeutic options. Read More

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September 2020