10,683 results match your criteria Femoral Head Avascular Necrosis

Comprehensive Proteomic Characterization of Articular Cartilage from Femoral Head Necrosis Patients.

Front Biosci (Landmark Ed) 2022 Jun;27(6):181

State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, Jiangsu, China.

Background: Avascular necrosis of the femoral head (AVNFH) is a progressive, multifactorial, and challenging clinical disease that causes hip pain and loss of hip joint function. Till now, the pathogenesis of AVNFH was not fully understood. In this study, we characterized cartilage protein profiles of patients with AVNFH and identified the potential proteins involved in the progress of AVNFH using proteomics technique. Read More

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Avascular Necrosis of Femoral Head-Overview and Current State of the Art.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland.

Avascular necrosis (AVN) of the femoral head is caused by disruption of the blood supply to the proximal femur. The alterations in the blood supply may occur following a traumatic event or result from a non-traumatic cause. Femoral neck fracture and hip dislocation and associated surgical procedures, corticosteroid therapy, and alcohol abuse frequently lead to AVN development. Read More

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Rare case of a low energy traumatic anterior dislocation of the native hip.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Trauma and Orthopaedics, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK.

Anterior dislocations of the native hip are rare injuries, and normally a result of high energy trauma such as road traffic accidents. Delays in reduction of over 12 hours have been shown to increase the risk of avascular necrosis to the head of the femur significantly. We report the case of an elderly man who sustained an anterior dislocation of his native hip following a fall. Read More

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Acta Ortop Bras 2022 15;30(2):e247996. Epub 2022 Apr 15.

Universidade de São Paulo, Medical School, Hospital das Clínicas, Institute of Orthopedics and Traumatology (IOT-HCFMUSP), São Paulo, SP, Brazil.

Many experimental models exist to better understand the necrosis of the femoral head etiology, both in terms of the species variety in which necrosis is induced and in the operative techniques used for treatment.

Objective: This study has two main objectives, the first is to review the literature concerning experimental models of avascular necrosis of the growing femoral head, the second, to demonstrate the experimental pig model's reproducibility using a pilot study.

Methods: This was a bibliographic review to describe the attempts over time to find the best species and technique for induction that would reproduce ischemic necrosis of the growing femoral head in humans. Read More

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Study on the Mechanism of Treating Femoral Head Necrosis with Drynariae Rhizoma Based on Network Pharmacology.

Comput Math Methods Med 2022 6;2022:3631722. Epub 2022 Jun 6.

Department of Orthopedics and Traumatology of Traditional Chinese Medicine, Third People's Hospital of Cixi, China.

Through the network pharmacology thought, the action target of the active ingredients of Drynariae Rhizoma was predicted, and the mapping was combined with the related targets of ONFH, and the key nodes of interaction were identified for enrichment analysis, so as to comprehensively explore the pharmacological mechanism of Drynariae Rhizoma against ONFH. The main active ingredients of Drynariae Rhizoma were screened based on pharmacokinetic characteristics in pharmacokinetic database and analysis platform of TCM system (TCMSP). We used the organic small molecule bioactivity database (PubChem) and Swiss target prediction database to predict related targets based on 2D or 3D structural similarity and then mined the known ONFH therapeutic targets through the Human Mendelian Genetic Database (OMIM) and Pubmed texts. Read More

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FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population.

BMC Med Genomics 2022 Jun 15;15(1):132. Epub 2022 Jun 15.

Department of Joint Surgery, Affiliated Hospital of Weifang Medical University, # 2428 Yuhe Road, Weifang, 261031, Shandong, China.

Background: Fat mass and obesity-related (FTO) mRNA was downregulated in osteonecrosis patients. The study aimed to evaluate the correlation between FTO polymorphisms and the susceptibility of osteonecrosis of the femoral head (ONFH).

Methods: Six polymorphisms in FTO were genotyped via the Agena MassARRAY in 498 ONFH patients and 498 healthy controls. Read More

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Radiographical and clinical results of a new conservative treatment algorithm in Legg-Calvè-Perthes disease: A retrospective study.

Acta Orthop Traumatol Turc 2022 May;56(3):187-193

Department of Orthopaedics and Traumatology, İstanbul Bilim University, İstanbul, Turkey.

Objective: This study aimed to establish a feasible conservative treatment algorithm for Legg-Calvè-Perthes Disease (LCPD), clarify its limitations, and evaluate the correlations between radiographical and clinical results.

Methods: Patients diagnosed with LCPD and treated conservatively were evaluated retrospectively; 39 hips from 35 patients were included. The treatment protocol consisted of intermittent manual traction, range of motion exercises, activity limitation, bed rest, NSAID (ibuprofen 100mg/5mL), and ASA (100mg/day) during attack periods. Read More

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The effect of endostatin on angiogenesis and osteogenesis of steroid-induced osteonecrosis of the femoral head in a rabbit model.

Acta Orthop Traumatol Turc 2022 May;56(3):178-186

Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China.

Objective: This study aimed to investigate whether endostatin, a crucial anti-angiogenic factor, plays a negative role in angiogenesis and osteogenesis and aggravates the progression of osteonecrosis of the femoral head induced by steroid use in a rabbit model.

Methods: 66 New Zealand white rabbits were randomly divided into four groups: glucocorticoid model (GC) group (GC group, n = 18), glucocorticoid model and endostatin group (GC;ES group, n = 18), ES group (ES group, n = 18), and blank control group (CON group, n = 12). In the GC group, 10 μg/ kg lipopolysaccharide (LPS) was intravenously injected into the ear margin, and 24h after LPS injection, 20 mg/kg GC methylprednisolone (MPS) was injected into the gluteus muscle three times, each time at an interval of 24h. Read More

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Surgical Treatment of Marginal Impaction Injuries of The Acetabulum Associated with Posterior Wall Fractures.

JBJS Essent Surg Tech 2022 Jan-Mar;12(1). Epub 2022 Mar 3.

Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, United Kingdom.

Posterior-wall acetabular fractures have been reported to be associated with marginal impaction characteristics in approximately 16% to 38% of cases. Early recognition of this special entity of joint impaction is essential for effective preoperative planning, intraoperative execution, and favorable outcomes. The 2-level reconstruction technique is safe and effective in experienced hands. Read More

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[Hip necrosis. A severe complication after intragluteal injection of quinine salt in Bangui, Central African Republic].

Med Trop Sante Int 2021 09 13;1(3). Epub 2021 Aug 13.

Service de chirurgie infantile, Complexe pédiatrique, Centre hospitalo-universitaire de Bangui, République centrafricaine.

Introduction: Intramuscular injection of quinine has been for long the most common treatment for malaria in children in endemic areas of Africa, especially sub-Saharan Africa, and remains too often used. However, it is frequently wrongly performed by unqualified people. When administered in a poorly developed or malnourished child, the injection can be done too deeply in the hip joint instead of the gluteus muscle area. Read More

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September 2021

Evaluation of Safety and Efficacy of Traction, Closed Reduction, and Subsequent Hip Fixation in Hilgenreiner Brace in Patients with Severe Forms of Hip Developmental Dysplasia.

Adv Orthop 2022 29;2022:8688770. Epub 2022 May 29.

Head of Teaching Department of Orthopaedics and Musculoskeletal Trauma, University of Pavol Jozef Šafárik, Kosice, Slovakia.

Background: Hilgenreiner brace (Hb) was developed to improve hip reduction rate and reduce the incidence of femoral head avascular necrosis (AVN). In children under the age of 18 months with unstable hip joints or a dislocated hip joint, the treatment method involves nonsurgical treatment in most cases.

Objectives: To evaluate the effectiveness and safety of traction, closed reduction, and hip fixation in Hb in patients with severe forms of hip developmental dysplasia (DDH) in follow-up. Read More

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Legg-Calvé-Perthes Disease.

N Engl J Med 2022 06;386(23):e62

Taipei Medical University, Taipei, Taiwan.

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Concomitant septic arthritis of the hip joint and femoral head avascular necrosis in patients with recent COVID-19 infection: a cautionary report.

J Orthop Surg Res 2022 Jun 6;17(1):302. Epub 2022 Jun 6.

Joint Reconstruction Research Centre, Tehran University of Medical Sciences, End of Keshavarz Blvd, Tehran, 1419733141, Iran.

Purpose: At present, concomitant avascular necrosis (AVN) of femoral head and septic arthritis (SA) as a sequel of COVID-19 infection has yet not been documented. By large-scale use of life-saving corticosteroids (CS) in COVID-19 cases, our aim is to warn of the occurrence of hip joint infection in these patients.

Methods: We report a series of five cases in which patients developed septic arthritis concomitant with AVN after being treated for COVID-19 infection. Read More

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Investigation of the process intergrowth of bone tissue into the hole in titanium implants (Experimental research).

Injury 2022 May 19. Epub 2022 May 19.

Klinik für Unfallchirurgie und Orthopädie, Handchirurgie Klinikum am Gesundbrunnen SLK-Kliniken Heilbronn GmbH Am Gesundbrunnen 20-26 74078 Heilbronn, Germany. Electronic address:

Introduction: Despite the use of modern implants, complications such as nonunion and avascular necrosis of the femoral head are observed in femoral neck fractures (FNF). We have created a new perforated I-beam implant for FNF osteosynthesis and developed a new osteosynthesis philosophy based not only on the mechanical and biomechanical interaction of the bone-implant system, but also on the interaction of the biological properties of the bone and the implant. The purpose of the work is to study the interaction of the biological process of the bone - its regeneration (germination) of bone tissue into the holes of the implant. Read More

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Plasminogen activator inhibitor-1 promoter sequence variations in idiopathic osteonecrosis of head of femur.

Indian J Med Res 2021 06;154(6):849-856

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Background & Objectives: Primary or idiopathic osteonecrosis of femur head (ONFH) is the second most commonly observed cause among Indian patients suffering from ischemic ONFH. Although a number of genetic polymorphisms have been associated with idiopathic ONFH pathogenesis in Korean and Chinese populations, there are no studies in the Indian population. This is an exploratory study designed to implicate in promoter sequence polymorphisms of a critical fibrinolytic system regulator, plasminogen activator inhibitor-1 (PAI-1) gene, in cases of idiopathic osteonecrosis. Read More

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Analysis of the femoral neck from rats in the periestropause treated with oxytocin and submitted to strength training.

Bone 2022 May 30;162:116452. Epub 2022 May 30.

Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, SBFis, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil. Electronic address:

Among the interventions used to prevent osteoporosis in female organisms, strength training (ST) and oxytocin (OT) stand out, as a promising hormone with anabolic action on bone. This study aimed to verify whether the combined action of OT and ST, compared to isolated interventions, potentiates the bone remodeling process of the femoral neck of Wistar rats during periestropause. Forty Wistar rats (18 months) with irregular estrous cycle were randomly distributed into groups: 1-Vehicle (Veh; NaCl 0. Read More

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Dislocation fracture of the femoral head in adult.

EFORT Open Rev 2022 May 31;7(6):375-383. Epub 2022 May 31.

Orthopédie Traumatologie, Secteur A, Batiment riquet, étage 5, CHU Toulouse, Toulouse Cedex 9, France.

The smaller the head fragment, the more likely it is located at the bottom and in front of the femoral head, which then determines the most suitable approach. A CT scan is essential after reduction and before resumption of weight-bearing to verify the size and congruence of the fragments and whether there are foreign bodies and/or a fracture of the posterior wall. Classifications should include the size of the fragment and whether or not there is an associated fracture of the acetabulum or femoral neck (historical 'Pipkin', modernised 'Chiron'). Read More

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Avascular necrosis during alectinib treatment: Case report.

Pınar Gürsoy

J Oncol Pharm Pract 2022 May 29:10781552221102370. Epub 2022 May 29.

Department Medical Oncology, Ege University School of Medicine, Izmir, Turkey.

Case Report: We present our patient who used alectinib due to anaplastic lymphoma kinase positivity and developed avascular necrosis in the femoral head.

Management And Outcome: In our patient who had been taking alectinib for a long time due to anaplastic lymphoma kinase positivity, avascular necrosis of the femoral head was detected as a result of the examination performed due to hip pain. Due to the responsıbılıty of the disease, her treatment contınued by making profit and loss account. Read More

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Symptomatic femoral head necrosis in patients with rheumatoid arthritis: A retrospective case-control study.

Immun Inflamm Dis 2022 Jun;10(6):e633

Department of Rheumatology, Fujian Provincial Hospital, Fuzhou, China.

Objective: We conducted a retrospective case-control study to investigate the risk factors for osteonecrosis of the femoral head (ONFH) in rheumatoid arthritis (RA) patients.

Methods: The clinical data of patients diagnosed with RA at Fujian Provincial Hospital from January 2013 to December 2020 were retrospectively collected and evaluated. Twenty-two patients with ONFH were identified. Read More

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Traumatic Hip Dislocation Associated with Proximal Femoral Physeal Fractures in Children: A Systematic Review.

Children (Basel) 2022 Apr 25;9(5). Epub 2022 Apr 25.

Department of Pediatric Orthopedic Surgery, "Grigore Alexandrescu" Clinical Emergency Hospital for Children, 011743 Bucharest, Romania.

Traumatic hip dislocation might lead to serious complications and a poor outcome. Fortunately, it is a rare condition in pediatric patients. The purpose of this study is to establish and describe the complications caused by hip dislocations associated with transphyseal femoral neck fractures. Read More

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The MRI Effect in Clinical Decision Process in Perthes' Disease: "More Complex Imaging, More Complicated Surgeries".

Acta Chir Orthop Traumatol Cech 2022 ;89(2):134-138

Ortopediatri, Pediatric Orthopedic Academy, Istanbul, Turkey.

PURPOSE OF THE STUDY Radiographs are preferred for understanding the deformity and containment in Legg-Calvé-Perthes disease (LCPD), as well as for treatment planning, but plain radiographs provide only static information and are inadequate for dynamic assessment of the joint. Magnetic resonance imaging (MRI) has been shown to be superior to other diagnostic modalities. The aim of this study was to determine the importance of hip MRI in LCPD treatment decision-making processes between pediatric orthopedic surgeons and orthopedic surgery residents. Read More

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Controlled repositioning and primary osteoplasty as a treatment option for the management of unstable slipped capital femoral epiphysis.

J Pediatr Orthop B 2022 Jul 24;31(4):359-364. Epub 2022 May 24.

Department of Orthoapedics and Spine Surgery, Ganga Hospital, Coimbatore, India.

The ideal management of an unstable slipped capital femoral epiphysis (SCFE) is still controversial. The currently available options are in-situ screw fixation with delayed corrective osteotomy, closed reduction and screw fixation and anatomic reduction by modified Dunn's procedure (MDP). We present the results of our technique of controlled re-positioning (CRP) with primary osteoplasty in which the epiphysis is repositioned to the preacute slip stage and a mini-open osteoplasty is done in the same sitting to avoid later femoro-acetabular impingement. Read More

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Effectiveness of Calcium Sulfate and Hydroxyapatite Composite in Collapse Prevention in Osteonecrosis of Femoral Head.

Cureus 2022 Apr 23;14(4):e24408. Epub 2022 Apr 23.

Orthopaedics, Hamdard Institute of Medical Sciences and Research, New Delhi, IND.

Introduction Calcium-sulfate-hydroxyapatite bioceramics have been widely used as void fillers in bone. However, their effectiveness as void fillers in core decompression for osteonecrosis of the femoral head (ONFH) in preventing femoral head collapse prevention has limited evidence. The current study investigates the effectiveness of calcium-sulfate-hydroxyapatite bioceramics as a void filler in the core decompression procedure for ONFH. Read More

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Outcomes of surgical hip dislocation combined with bone graft for adolescents and younger adults with osteonecrosis of the femoral head: a case series and literature review.

BMC Musculoskelet Disord 2022 May 26;23(1):499. Epub 2022 May 26.

Department of Joint Diseases, Traumatology & Orthopedics Institute of Guangzhou University of Chinese Medicine, The Third Afliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Background: Osteonecrosis of the femoral head (ONFH) may occur in the adolescent and younger adults (AYAs). Total hip arthroplasty (THA) is not the best treatment option for younger patients. Surgical hip dislocation (SHD) combined with bone graft can be used in patients at different stages to reconstruct the bone structure in the head and delay the replacement time. Read More

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MicroRNA‑141 inhibits the differentiation of bone marrow‑derived mesenchymal stem cells in steroid‑induced osteonecrosis via E2F3.

Mol Med Rep 2022 Jul 26;26(1). Epub 2022 May 26.

Department of Orthopedic Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China.

Osteonecrosis of the femoral head (ONFH) affects the life of patients. MicroRNA‑141 (miR‑141) has been found associated with proliferation of bone marrow‑derived mesenchymal stem cells (BMSCs). E2F transcription factor 3 (E2F3) has been identified as the target of miR‑141 to regulate cell proliferation. Read More

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Is the modified Dunn's procedure superior to in situ fixation? A systematic review and meta-analysis of comparative studies for management of moderate and severe slipped capital femoral epiphysis.

J Child Orthop 2022 Feb 5;16(1):27-34. Epub 2022 Apr 5.

Department of Trauma and Orthopaedics, Alice Springs Hospital, Alice Springs, NT, Australia.

Purpose: The management of moderate and severe slipped capital femoral epiphysis is controversial. While in situ fixation is commonly used, the modified Dunn's procedure is increasingly popular within high-volume centers. We compared the clinical and radiological outcomes, as well as the rates of femoral head avascular necrosis or chondrolysis in patients managed with either modified Dunn's procedure or in situ fixation. Read More

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February 2022

Circ_0058792 regulates osteogenic differentiation through miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the femoral head.

Bioengineered 2022 05;13(5):12807-12822

Department of Emergency Traumatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Osteonecrosis of the femoral head (ONFH) caused by steroids is a severe orthopedic disorder resulting from the use of high-dose steroid drugs, characterized by structural changes in the bone, joint dysfunction, and femoral head collapse. CircRNAs and miRNAs have increasingly been suggested to play pivotal roles in osteogenic differentiation and osteogenesis. Significant upregulation of circ_0058792 was observed in patients with steroid-induced ONFH. Read More

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Does the femoral neck system provide better outcomes compared to cannulated screws fixation for the management of femoral neck fracture in young adults? A systematic review of literature and meta-analysis.

J Orthop 2022 Jul-Aug;32:52-59. Epub 2022 May 11.

Department of Orthopedics, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background: Management of neck of femur fractures depend upon the age of presentation and it ranges from internal fixation to arthroplasty. In a relatively young population, anatomical reduction with stable internal fixation is the preferred treatment modality; the choice of implants available are multiple cannulated cancellous screws, dynamic hip screws, and the newly devised femoral neck system. The fracture configuration and pattern dictate the ideal implant to be utilized, with the femoral neck system documented to be apt for all the fracture types, while the cannulated screws are deemed better for stable fractures. Read More

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Micro-Computed Tomography Analysis of Femoral Head Necrosis After Long-Term Internal Fixation for Femoral Neck Fracture.

Orthop Surg 2022 Jun 19;14(6):1186-1192. Epub 2022 May 19.

Department of Orthopaedics, Second Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To analyze necrotic femoral head after long-term internal fixation for femoral neck fractures using micro-computed tomography (CT) for bone histomorphometry.

Methods: The experimental group included six patients (two men and four women; mean age 62.00 ± 9. Read More

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Conversion hip arthroplasty via the direct anterior approach: pearls, pitfalls and personal experience.

Oper Orthop Traumatol 2022 Jun 17;34(3):177-188. Epub 2022 May 17.

Arthroplasty Center, Helios Klinikum Munich West, Munich, Germany.

Objective: Conversion total hip arthroplasty (CTHA) through a direct anterior approach (DAA) in supine position.

Indications: Failed osteosynthesis of proximal femoral fractures or failed conservative hip surgery, with hardware in situ.

Contraindications: Decayed general conditions, infection (peri-implant or systemic infection), need for greater trochanter reconstruction, severe proximal femur deformity. Read More

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