9,398 results match your criteria Femoral Head Avascular Necrosis


Results of 200 Consecutive Ceramic-on-Ceramic Cementless Hip Arthroplasties in Patients Up To 50 Years of Age: A 5-24 Years of Follow-Up Study.

J Arthroplasty 2019 Jan 31. Epub 2019 Jan 31.

Department of Basic Medical Sciences, Neuroscience and Organs of Sense, School of Medicine, AOU Policlinico Consorziale, Università di Bari "Aldo Moro", Bari, Italy.

Background: Ceramic-on-ceramic (CoC) bearings due to their mechanical properties can be used in primary total hip arthroplasty (THA) especially in young patients requiring a long-lasting implant. The goal of this study is to analyze the results of a series of 200 consecutive CoC THAs in patients aged 50 years or less at the time of surgery.

Methods: A retrospective study was conducted on the first 200 consecutive CoC arthroplasties performed using the direct lateral approach on 105 females and 81 males (14 bilateral cases) with an average age of 44. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.057DOI Listing
January 2019

[Safety and efficacy of total hip arthroplasty following failed internal fixation of intertrochanteric fractures].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):160-165

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To evaluate the safety and efficacy of total hip arthroplasty (THA) following failed internal fixation of intertrochanteric fractures.

Methods: Between January 2007 and January 2016, THAs were performed in 32 patients (33 hips) for failed internal fixation of intertrochanteric fractures. There were 15 males and 17 females, with mean age of 74. Read More

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http://dx.doi.org/10.7507/1002-1892.201807089DOI Listing
February 2019
1 Read

Closed Reduction for Developmental Dysplasia of the Hip: Early-term Results From a Prospective, Multicenter Cohort.

J Pediatr Orthop 2019 Mar;39(3):111-118

Arnold Palmer Medical Center, Orlando, FL.

Background: Closed reduction (CR) is a common treatment for infantile developmental dysplasia of the hip. The purpose of this observational, prospective, multicenter study was to determine the early outcomes following CR.

Methods: Prospectively collected data from an international multicenter study group was analyzed for patients treated from 2010 to 2014. Read More

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http://dx.doi.org/10.1097/BPO.0000000000000895DOI Listing
March 2019
2 Reads

Asymmetric bilateral hip dislocation in young man: a case report.

Acta Biomed 2019 Jan 10;90(1-S):183-186. Epub 2019 Jan 10.

Orthopedic and Traumatology Unit, Ospedale San Bortolo, Vicenza.

Bilateral hip dislocation is a rare event, asymmetric dislocation is even rarer. Due to the intrinsic stability of the hip joint this lesions usually follow a high energy trauma. Because of the common associated lesions, the initial clinical assessment should be performed thoroughly. Read More

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http://dx.doi.org/10.23750/abm.v90i1-S.8067DOI Listing
January 2019
2 Reads

Preoperative planning of femoral head reduction osteotomy using 3D printing model: A report of two cases.

Acta Orthop Traumatol Turc 2019 Jan 29. Epub 2019 Jan 29.

Acıbadem University, School of Medicine, Istanbul, Turkey.

The deformed and enlarged femoral head secondary to hip diseases such as Legg Calve Perthes and Developmental Dysplasia usually causes impingement between the aspherical head and the acetabulum. To restore and reduce the size of enlarged femoral head, a femoral head reduction technique has been described previously. The goal is to obtain a spherical femoral head and to cover the gliding surface with best available cartilage. Read More

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http://dx.doi.org/10.1016/j.aott.2019.01.002DOI Listing
January 2019
1 Read

The outcome of in-situ fixation of unstable slipped capital femoral epiphysis.

J Pediatr Orthop B 2019 Jan 29. Epub 2019 Jan 29.

Orthopaedic Institute for Children.

There is limited information regarding the outcome of in-situ fixation of unstable slipped capital femoral epiphysis (U-SCFE). We aimed to report the outcome of a cohort of patients with U-SCFE that were treated with in-situ fixation, by comparing it to the outcome of patients with stable slipped capital femoral epiphysis (S-SCFE).After Institutional Review Board approval, a retrospective analysis of patients with SCFE that were treated with in-situ fixation at a single institution between 2005 and 2016 was performed. Read More

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http://dx.doi.org/10.1097/BPB.0000000000000596DOI Listing
January 2019
1 Read

Subtraction osteotomy of the humeral head in posterior shoulder dislocation: a case report.

Eur J Orthop Surg Traumatol 2019 Jan 28. Epub 2019 Jan 28.

High Resolution Hospital Ecija, Seville, Spain.

Locked posterior dislocations of the shoulder with an impacted fracture of the humeral head and an articular surface defect greater than 35-40% are generally treated with a femoral head bone graft or prosthesis. We present a case in which a subtraction osteotomy with osteoclasia on the impacted zone was performed to try to make the articular surface of the humeral head congruent and continuous. With a 42-month follow-up, the clinical outcome, in terms of mobility and pain, was very good; X-rays show there was no avascular necrosis of the humeral head nor signs of articular arthrosis. Read More

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http://dx.doi.org/10.1007/s00590-019-02388-5DOI Listing
January 2019
1 Read

Manual red cell exchange transfusion to avert sickle cell related complications.

Asian J Transfus Sci 2018 Jul-Dec;12(2):157-159

Department of Immunohematology and Blood Transfusion, MGM Medical College and Hospital, Mumbai, Maharashtra, India.

Sickle cell-beta thalassemia is a double heterozygous state. Red cell exchange (RCE) transfusion reduces the concentration of sickle cells without increasing the hematocrit or whole-blood viscosity. It can be performed manually or by erythrocytapheresis. Read More

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http://www.ajts.org/text.asp?2018/12/2/157/247983
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http://dx.doi.org/10.4103/ajts.AJTS_128_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327770PMC
January 2019
4 Reads

Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis.

Transfus Clin Biol 2019 Jan 10. Epub 2019 Jan 10.

Sickle Cell Institute Chhattisgarh, Forest Block-2, Jail Road, Raipur 492001, Chhattisgarh India. Electronic address:

Sickle cell disease (SCD) is considered as a vascular disease due to its chronic vascular manifestations such as leg ulcers, priapism, acute chest syndrome (ACS), stroke, retinopathy, renal insufficiency, pulmonary hypertension, avascular necrosis of the femoral head (AVNF) and splenic infarction. Emerging evidence has shown that the MTHFR 677C>T variant allele is associated with vascular complications (VC) in patients with SCD; however, results from individual studies are inconclusive. The aim of this meta-analysis is to evaluate the association between the MTHFR 677C>T polymorphism and the susceptibility for VC in SCD patients. Read More

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http://dx.doi.org/10.1016/j.tracli.2019.01.003DOI Listing
January 2019
1 Read

Traumatic hip fracture-dislocation: A middle-term follow up study and a proposal of new classification system of hip joint associated injury.

Injury 2019 Jan 17. Epub 2019 Jan 17.

Section of Orthopaedics and Trauma Surgery, Ospedali Riuniti, Ancona, Italy. Electronic address:

Traumatic hip fracture dislocation is a rare injury associated with high-energy trauma. Most of these injuries should be surgically treated. Hip dislocation is an orthopaedic emergency and reduction must be performed within 6-8 hours of trauma. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.011DOI Listing
January 2019

Joint replacement surgery in Ghana (West Africa)-an observational study.

Int Orthop 2019 Jan 24. Epub 2019 Jan 24.

West Hertfordshire NHS Trust, St. Joseph's Orthopaedic Hospital, Koforidua, Ghana.

Introduction: With the continued and effective transfer of orthopaedic knowledge and skills across continents, the incidence of hip and knee replacement surgery has increased in the developing world. More patients are having these procedures done locally rather than having to travel over to the more developed western countries at great financial costs for those who cannot really afford it. We report the data collected by an orthopaedic charity MOTEC LIFE UK which has been offering hip and knee arthroplasty procedures to patients who require them. Read More

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http://link.springer.com/10.1007/s00264-019-04286-1
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http://dx.doi.org/10.1007/s00264-019-04286-1DOI Listing
January 2019
4 Reads

Detection of avascular necrosis on routine diffusion-weighted whole body MRI in patients with multiple myeloma.

Br J Radiol 2019 Feb 12:20180822. Epub 2019 Feb 12.

4 Department of Radiology, The Royal Marsden Hospital and Faculty of Radiotherapy and Imaging Institute of Cancer Research , London , UK.

Objective:: Current therapies for multiple myeloma, which include corticosteroids, increase risk of avascular necrosis. The aim of this study was to assess incidental detection of femoral head avascular necrosis on routine whole body MRI including diffusion weighted MRI.

Methods:: All whole body MRI studies, performed on patients with known multiple myeloma between 1 January 2010 to 1 May 2017 were assessed for features of avascular necrosis. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180822
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http://dx.doi.org/10.1259/bjr.20180822DOI Listing
February 2019
1 Read
1.533 Impact Factor

Locking Plate Fixation with Multiple Telescoping Sliding Screws for Femoral Neck Fractures.

Ortop Traumatol Rehabil 2018 Dec;20(6):493-498

Department of Orthopedics, Faculty of Medicine, Comenius University and The National Institute of Children's Diseases, Bratislava, Slovakia.

Background: Non-displaced femoral neck fractures are mostly treated with internal fixation, while in dis-placed fractures this surgical option is under debate and the benefits are still not clear. The purpose of this study was to identify the factors that affect the treatment of non-displaced and displaced hip fractures using a head-preserving plate.

Material And Methods: From August 2011 to May 2015, we reviewed eighty-two adult patients who had sustained undisplaced and displaced intracapsular femoral neck fracture treated with a locking plate system with telescoping sliding screws. Read More

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December 2018
2 Reads

[Lead intoxication revealing sickle cell disease].

Pan Afr Med J 2018 31;30:305. Epub 2018 Aug 31.

Service de Rhumatologie, CHU Mohammed VI, BP 2360 principal, Avenue Ibn Sina, Marrakech, Maroc.

We here report the case of a 18 year old patient with two brothers who died from sickle cell anemia. He had a 5-day history of diffuse bone pain. He had drunk a preparation containing lead to obtain an analgesic effect without improvement. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.305.16222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320453PMC
January 2019
1 Read

Effect of psoralen on the expression of PPARγ, osteocalcin, and trabecular bone area in rabbits with steroid-induced avascular necrosis of the femoral head.

J Orthop Surg Res 2019 Jan 8;14(1):11. Epub 2019 Jan 8.

Orthopedics Department, The First Affiliated Hospital of Henan University of Chinese Medicine, 19 Renmin Road, Zhengzhou, 450000, Henan, China.

Objective: Psoralen is a natural plant toxin which has the function of protecting fungi, insects, and herbivores. In this study, we aim to investigate the effect and mechanism of psoralen on steroid-induced avascular necrosis of femoral head (SANFH).

Methods: Thirty rabbits were randomly divided into blank group (n = 10), model group (n = 10), and experimental group (n = 10). Read More

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http://dx.doi.org/10.1186/s13018-018-1054-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325724PMC
January 2019
1 Read

Prediction of mechanical behavior of cartilaginous infant hips in pavlik harness: A subject-specific simulation study on normal and dysplastic hips.

J Orthop Res 2019 Jan 3. Epub 2019 Jan 3.

Department of Radiology and Diagnostic Imaging, University of Alberta, 2A2.41 WMC, 8440-112 Street, Edmonton, Alberta, T6G 2B7, Canada.

In dysplastic infant hips undergoing abduction harness treatment, cartilage contact pressure is believed to have a role in therapeutic cartilage remodeling and also in the complication of femoral head avascular necrosis. To improve our understanding of the role of contact pressure in the remodeling and the complication, we modeled cartilage contact pressure in cartilaginous infant hips undergoing Pavlik harness treatment. In subject-specific finite element modeling, we simulated contact pressure of normal and dysplastic hips in Pavlik harness at 90° flexion and gravity-induced abduction angles of 40°, 60° and 80°. Read More

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http://dx.doi.org/10.1002/jor.24213DOI Listing
January 2019
3 Reads

Segmentation of the proximal femur in radial MR scans using a random forest classifier and deformable model registration.

Int J Comput Assist Radiol Surg 2019 Jan 2. Epub 2019 Jan 2.

School of Health Sciences - Geneva, HES-SO University of Applied Sciences and Arts Western Switzerland, Avenue de Champel 47, 1206, Geneva, Switzerland.

Background: Radial 2D MRI scans of the hip are routinely used for the diagnosis of the cam type of femoroacetabular impingement (FAI) and of avascular necrosis (AVN) of the femoral head, both considered causes of hip joint osteoarthritis in young and active patients. A method for automated and accurate segmentation of the proximal femur from radial MRI scans could be very useful in both clinical routine and biomechanical studies. However, to our knowledge, no such method has been published before. Read More

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http://link.springer.com/10.1007/s11548-018-1899-z
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http://dx.doi.org/10.1007/s11548-018-1899-zDOI Listing
January 2019
11 Reads

Lateral rim mesh in primary total hip arthroplasty.

Bone Joint J 2019 Jan;101-B(1):96-103

Department of Orthopaedics, Radboud University Medical Center, Nijmegen, The Netherlands.

Aims: The aim of this study was to analyze the effect of a lateral rim mesh on the survival of primary total hip arthroplasty (THA) in young patients, aged 50 years or younger.

Patients And Methods: We compared a study group of 235 patients (257 hips) who received a primary THA with the use of impaction bone grafting (IBG) with an additional lateral rim mesh with a group of 306 patients (343 hips) who received IBG in the absence of a lateral rim mesh during the same period from 1988 to 2015. In the mesh group, there were 74 male and 183 female patients, with a mean age of 35 years (13 to 50). Read More

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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0561.R2DOI Listing
January 2019
2 Reads

Avascular necrosis of the femoral head: An exceptional complication of cushing's disease.

Ann Afr Med 2018 Oct-Dec;17(4):225-227

Department of Endocrinology and Diabetology, University Hospital of Fez, Fez, Morocco.

Avascular necrosis (AVN) of the femoral head is a well-recognized complication of steroid treatment. Exogenous glucocorticoids' administration and alcoholism are the most common nontraumatic etiologies. AVN secondary to endogenous hypercortisolism (HC) is rare; very few case reports are available on this complication. Read More

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http://dx.doi.org/10.4103/aam.aam_75_17DOI Listing
December 2018
8 Reads

Traction does not decrease failure of reduction and femoral head avascular necrosis in patients aged 6-24 months with developmental dysplasia of the hip treated by closed reduction: a review of 385 patients and meta-analysis.

J Pediatr Orthop B 2018 Dec 21. Epub 2018 Dec 21.

Department of Pediatric Orthopaedics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou.

This study aimed to investigate the effects of preliminary traction on the rate of failure of reduction and the incidence of femoral head avascular necrosis (AVN) in patients with late-detected developmental dysplasia of the hip treated by closed reduction. A total of 385 patients (440 hips) treated by closed reduction satisfied the inclusion criteria. Patients were divided in two groups according to treatment modality: a traction group (276 patients) and a no-traction group (109 patients). Read More

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http://dx.doi.org/10.1097/BPB.0000000000000586DOI Listing
December 2018
3 Reads

[Comparison of effectiveness between two combined anterior and posterior approaches for complicated acetabular fractures].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Dec;32(12):1512-1517

Department of Orthopaedics, the Second Hospital of Anhui Medical University, Hefei Anhui, 230603,

Objective: To compare the effectiveness between modified ilioinguinal approach combined with Kocher-Langenbeck (K-L) approach and Stoppa approach combined with K-L approach for the treatment of complicated acetabular fractures.

Methods: Between May 2011 and May 2016, Sixty-two patients with complicated acetabular fractures were treated with operation via combined anterior and posterior approaches. Thirty-four cases (group A) were treated with modified ilioinguinal approach combined with K-L approach, and 28 cases (group B) were treated with Stoppa approach combined with K-L approach. Read More

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http://dx.doi.org/10.7507/1002-1892.201806096DOI Listing
December 2018
1 Read

[Treatment of avascular necrosis of femoral head in patients with human immunodeficiency virus infection by cementless total hip arthroplasty].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Dec;32(12):1507-1511

Department of Orthopaedics, the First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000, P.R.China.

Objective: To investigate the effectiveness of cementless total hip arthroplasty (THA) in treatment of avascular necrosis of the femoral head (ANFH) in patients with human immunodeficiency virus (HIV) infection.

Methods: The clinical data of 22 patients (35 hips) with HIV infection and ANFH (positive group), who were treated with cementless THA between February 2014 and January 2017, was retrospectively analyzed. Tirty-three cases (43 hips) without HIV infection, who were treated with cementless THA during the same period, were collected as control (negative group). Read More

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http://dx.doi.org/10.7507/1002-1892.201806126DOI Listing
December 2018
3 Reads

Pinnacle polyethylene liner dissociation: a report of 3 cases.

Arthroplast Today 2018 Dec 11;4(4):441-446. Epub 2018 Sep 11.

Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT, USA.

We describe 3 cases of DePuy Pinnacle polyethylene dissociations, their presentations, and treatment. A 34-year-old female with arthritis secondary to dysplasia, a 51-year-old male with avascular necrosis of the femoral head, and a 57-year-old female with osteoarthritis were treated with total hip arthroplasty. Acute nontraumatic polyethylene liner dissociations occurred at 31, 42, and 2 months postoperatively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523441183008
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http://dx.doi.org/10.1016/j.artd.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287959PMC
December 2018
9 Reads

Effects of Endoprosthesis Head Material on Acetabular Cartilage Metabolism: An Animal Study Using Crossbred Pigs.

J Nippon Med Sch 2018 ;85(6):309-314

Department of Orthopedic Surgery, Nippon Medical School.

Background: Hip endoprosthesis is one option for the treatment of displaced femoral neck fractures and avascular necrosis of the femoral head. Few reports are available describing acetabular cartilage metabolism after endoprosthesis surgery of the hip. The purpose of this study was to compare the biological effects on cartilage between cobalt-chrome (Co-Cr) and alumina ceramic heads wherein the cartilage articulates directly. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-50DOI Listing
January 2018
2 Reads

[Iatrogenic femoral head fracture during a closed reduction of posterior dislocation of hip. Case report].

Acta Ortop Mex 2018 Jul-Aug;32(4):234-239

Servicio de Cadera y Pelvis del Hospital General de Querétaro. Querétaro, México.

The fracture dislocation of the hip is a rare lesion described up to 4 to 17% of the cases and usually secondary to automobile accidents. Generally of poor prognosis and with already well documented complications such as avascular necrosis of the femoral head, osteoarthritis and heterotopic ossification. The iatrogenic fracture of the neck or head of the proximal femur is a complication even more rare and is not documented its incidence in the world literature. Read More

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December 2018
2 Reads

Epimedium protects steroid-induced avascular necrosis of femoral head in rats by inhibiting autophagy.

Exp Ther Med 2018 Dec 3;16(6):5047-5052. Epub 2018 Oct 3.

Department of Orthopedics, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu 215600, P.R. China.

The effect of epimedium extracting solution on bone mineral density (BMD) of steroid-induced avascular necrosis of femoral head (SANFH) in rats was evaluated to further explore its function mechanism. Twenty-four Sprague-Dawley (SD) rats (male/female: 1/1) were randomly divided into three groups: the control (n=8), the glucocorticoid (n=8) and the epimedium (n=8) group. Rats in the glucocorticoid and the epimedium group were injected with prednisolone acetate injection in gluteal muscles with 15 mg/kg/day twice a week. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.6827
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http://dx.doi.org/10.3892/etm.2018.6827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257266PMC
December 2018
1 Read

Technologies for Young Femoral Neck Fracture Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S20-S26

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Fixation of young femoral neck fractures represents a challenge in the field of orthopaedic trauma surgery. Conventional methods, including cannulated screw and sliding hip screw constructs, have been studied and found to have similar results with regards to patient outcomes, which has made choosing an optimum fixation strategy difficult. In all of these cases, quality of reduction has been shown to be the most important factor when it comes to creating a favorable environment for fracture healing. Read More

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http://Insights.ovid.com/crossref?an=00005131-201901001-0000
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http://dx.doi.org/10.1097/BOT.0000000000001367DOI Listing
January 2019
12 Reads

Immunohistochemical analysis of bone metabolism in osteonecrosis of the femoral head.

Rom J Morphol Embryol 2018 ;59(3):819-824

Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania; Urodiamed Clinic, Craiova, Romania;

Osteonecrosis of the femoral head occurs because of the suppression of blood circulation. At the level of the area affected by the ischemic phenomenon, there are two types of events, in the first stage there is necrosis of the cellular elements, followed by a reparatory phase of the spongy bone tissue. The objective of the study was the histological and immunohistochemical (IHC) analysis of bone metabolism in the repair phase. Read More

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December 2018
2 Reads

One-stage Hip Reconstruction for Developmental Hip Dysplasia in Children over 8 Years of Age.

Hip Pelvis 2018 Dec 6;30(4):260-268. Epub 2018 Dec 6.

Department of Orthopaedic and Spine Surgery, Ghurki Trust Teaching Hospital, Lahore, Pakistan.

Purpose: This study was performed to assess the clinical and radiological outcomes following one-stage hip reconstruction, consisting of open reduction femoral shortening and pelvic osteotomy, for neglected developmental dislocation of the hip (DDH).

Materials And Methods: This is a retrospective analysis of 77 hips in 65 patients (46 females and 19 males; 12 had bilateral dislocations), operated at a Ghurki Trust Teaching Hospital in Pakistan between 2013 and 2015. The average age at surgery was 11. Read More

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http://dx.doi.org/10.5371/hp.2018.30.4.260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284078PMC
December 2018
3 Reads

Incidence and severity of femoral head avascularity after femoral neck or intertrochanteric fractures on preoperative bone single photon emission computed tomography/computed tomography: preliminary study.

Nucl Med Commun 2019 Mar;40(3):199-205

Department of Nuclear Medicine, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Cyclotron Research Center, Molecular Imaging and Therapeutic Medicine Research Center, Chonbuk National University Medical School and Hospital.

Objective: The aim of the present study was to evaluate the incidence and degree of femoral head avascularity depending on the types of femoral neck or intertrochanteric fractures using preoperative bone single photon emission computed tomography (SPECT)/computed tomography (CT).

Patients And Methods: A total of 131 patients with femoral neck or intertrochanteric fractures who underwent preoperative bone SPECT/CT were enrolled. Femoral head avascularity was evaluated using bone SPECT/CT images. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000963DOI Listing
March 2019
2 Reads

Downregulating STAT1/caspase-3 signaling with fludarabine to alleviate progression in a rat model of steroid-induced avascular necrosis of the femoral head.

J Biochem Mol Toxicol 2018 Dec 1:e22265. Epub 2018 Dec 1.

Department of Orthopaedic, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Steroid-induced avascular necrosis of the femoral head (SANFH) is mainly induced by glucocorticoids. Fludarabine (Flu) is a specific signal transducer and activator of transcription 1 (STAT1) inhibitor. In this study, we investigated the effect of Flu on SANFH and the role played by the STAT1/caspase-3 signaling pathway. Read More

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http://dx.doi.org/10.1002/jbt.22265DOI Listing
December 2018
1 Read

Real-World Database Examining the Association Between Avascular Necrosis of the Femoral Head and Diabetes in Taiwan.

Diabetes Care 2018 Nov 28. Epub 2018 Nov 28.

College of Medicine, Tzu Chi University, Hualien, Taiwan

Objective: No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan.

Research Design And Methods: A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Program. Read More

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http://dx.doi.org/10.2337/dc18-1258DOI Listing
November 2018
7 Reads

Avascular necrosis post unstable slipped capital femoral epiphysis: a treatment algorithm with staged hinged hip distraction: mid-term results.

Hip Int 2018 Nov 20:1120700018811313. Epub 2018 Nov 20.

Department of Trauma and Orthopaedics, Sheffield Children's Hospital, Sheffield, UK.

Background:: Management of avascular necrosis (AVN) of the femoral head in slipped capital femoral epiphysis (SCFE) is difficult. We proposed to ascertain if staged hip distraction could prevent collapse and recover the femoral head.

Methods:: A retrospective review of the hip database retrieved 16 children with unstable SCFE and AVN. Read More

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http://dx.doi.org/10.1177/1120700018811313DOI Listing
November 2018
8 Reads

Autologous stem cell implantation with core decompression for avascular necrosis of the femoral head.

J Clin Orthop Trauma 2018 Oct-Dec;9(4):349-352. Epub 2018 Jun 2.

Department of Orthopaedic Surgery, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.

Objective: Avascular necrosis (AVN) of the femoral head is a painful, progressive disease that can lead to limited mobility and early hip replacement. Autologous stem cell implantation into the necrotic lesion of the femoral head has been described, on the basis that patients with AVN have a reduced number of stem cells in the marrow. In this study, we aim to describe our technique for decompression of the hip with autologous implantation of stem cells for AVN of the femoral head, as well as retrospectively analyze our results. Read More

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http://dx.doi.org/10.1016/j.jcot.2018.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224688PMC
June 2018
12 Reads

Long Non-Coding RNA MALAT1 Protects Human Osteoblasts from Dexamethasone-Induced Injury via Activation of PPM1E-AMPK Signaling.

Cell Physiol Biochem 2018 15;51(1):31-45. Epub 2018 Nov 15.

Department of Orthopaedics, The Second Affiliated Hospital of Nantong University, Nantong,

Background/aims: Dexamethasone (Dex) induces injuries to human osteoblasts. In this study, we tested the potential role of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Lnc-MALAT1) in this process.

Materials: Two established human osteoblastic cell lines (OB-6 and hFOB1. Read More

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https://www.karger.com/Article/FullText/495159
Publisher Site
http://dx.doi.org/10.1159/000495159DOI Listing
December 2018
10 Reads

Beneficial contribution of a safflower (Carthamus tinctorius L.) polysaccharide on steroid-induced avascular necrosis of the femoral head in rats.

Int J Biol Macromol 2019 Feb 9;123:581-586. Epub 2018 Nov 9.

Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, No 6 Jiefang Street, Zhongshan District, Dalian 116001, China.

A water-soluble polysaccharide (SPS) was purified from dried safflower (Carthamus tinctorius L.) and its structure was identified using a combination of chemical and instrumental analysis. SPS has a repeating backbone of 1,4,6-β-Glcp, which was attached with T-β-Glcp at its C6 position along the main chain in the molar ratio of 1:1. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.11.046DOI Listing
February 2019
2 Reads

The mean ten-year results of metal-on-metal hybrid hip resurfacing arthroplasty.

Bone Joint J 2018 Nov;100-B(11):1424-1433

Joint Replacement Institute at St Vincent Medical Center, Los Angeles, California, USA.

Aims: This study presents the long-term survivorship, risk factors for prosthesis survival, and an assessment of the long-term effects of changes in surgical technique in a large series of patients treated by metal-on-metal (MoM) hip resurfacing arthroplasty (HRA).

Patients And Methods: Between November 1996 and January 2012, 1074 patients (1321 hips) underwent HRA using the Conserve Plus Hip Resurfacing System. There were 787 men (73%) and 287 women (27%) with a mean age of 51 years (14 to 83). Read More

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https://online.boneandjoint.org.uk/doi/10.1302/0301-620X.100
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http://dx.doi.org/10.1302/0301-620X.100B11.BJJ-2017-1459.R2DOI Listing
November 2018
9 Reads

[Effect and mechanisms of vitamin E on early steroid-induced avascular necrosis of femoral head in rats].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Nov;32(11):1421-1428

The First Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710004,

Objective: To investigate the possibility of mitochondria-dependent apoptosis as a mechanism of early steroid-induced avascular necrosis of femoral head (SANFH) in rats and vitamin E as a possible prevention strategy.

Methods: Seventy-two male Sprague Dawley rats were randomly divided into control group, model group, and intervention group, with 24 rats in each group. The rats in control group were not treated as normal control. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201801046
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http://dx.doi.org/10.7507/1002-1892.201801046DOI Listing
November 2018
12 Reads

[Effectiveness of F-shaped screw fixation technique in treatment of Pauwels type femoral neck fractures].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Nov;32(11):1417-1420

Department of Orthopaedics, Central Hospital of Nanyang, Nanyang Henan, 473000, P.R.China.

Objective: To summarize the effectiveness of F-shaped screw fixation technique in treatment of Pauwels type Ⅲ femoral neck fractures.

Methods: Between January 2013 and December 2016, 43 patients with Pauwels type Ⅲ femoral neck fractures were treated with F-shaped screw fixation technique. There were 32 males and 11 females with an average age of 38. Read More

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http://dx.doi.org/10.7507/1002-1892.201805111DOI Listing
November 2018
2 Reads

Autologous bone marrow-derived CD133 cells with core decompression as a novel treatment method for femoral head osteonecrosis: a pilot study.

Cytotherapy 2019 Jan 5;21(1):107-112. Epub 2018 Nov 5.

Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran. Electronic address:

Background: Avascular necrosis (AVN) of femoral head is a progressive bone disease due to ischemia of femoral head; patients experience pain and they can not do normal activity. There is not an effective way to treat the cause of this disease. In recent studies, treatment of this disease using pluripotent stem cell-derived mesenchyme is safe and effective, but this method needs more investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14653249183064
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http://dx.doi.org/10.1016/j.jcyt.2018.10.005DOI Listing
January 2019
9 Reads

Analysis of the long-term efficacy of core decompression with synthetic calcium-sulfate bone grafting on non-traumatic osteonecrosis of the femoral head.

Med Sci (Paris) 2018 Oct 7;34 Focus issue F1:43-46. Epub 2018 Nov 7.

Department of general surgery, 6th affiliated hospital of Wenzhou medical university (Lishui People's Hospital), Lishui Zhejiang province, No.15 Dazhong Road, Liandu district, Lishui 323000 PR China.

Objective: to investigate the safety and long-term efficacy of core decompression with synthetic calcium-sulfate bone grafting on non-traumatic osteonecrosis of the femoral head.

Method: a total of 76 patients with non-traumatic osteonecrosis of the femoral head were admitted to our hospital from February 2012 to November 2014 and included in the study. All the patients were treated by core decompression with synthetic calcium-sulfate bone grafting. Read More

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http://dx.doi.org/10.1051/medsci/201834f108DOI Listing
October 2018
2 Reads

[Effect of robot navigation assisted core decompression combined with bone graft treatment of early stage osteonecrosis of the femoral head].

Zhonghua Wai Ke Za Zhi 2018 Nov;56(11):849-853

Department of Osteoarthropathy, Yantaishan Hospital, Yantai 264001, China.

To evaluate the effects of orthopedic robot navigation system used in core decompression combined with bone graft surgery for osteonecrosis of the femoral head (ONFH). A retrospective analysis was performed on 9 patients (16 hips) underwent core decompression surgery combined with bone graft treatment for early ONFH in ARCO Ⅱat Department of Osteoarthropathy, Yantaishan Hospital from June 2016 to February 2018.There were 7 males and 2 females, aged 44. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2018.11.011DOI Listing
November 2018
10 Reads

Effect of surgical treatment on the quality of life in patients with non-traumatic avascular necrosis of the femoral head.

Rev Bras Ortop 2018 Nov-Dec;53(6):773-777. Epub 2018 Feb 3.

Medical School, Kermanshah University of Medical Science, Kermanshah, Iran.

Objective: Avascular necrosis of the hip is a common debilitating disease during the fourth and fifth decades of life. This study attempted to evaluate quality of life in patients with avascular necrosis of the hip joint before and after surgery.

Methods: In this study, 40 patients with avascular necrosis of the hip who underwent total hip arthroplasty, bipolar surgery, or cord compression were examined during 2006-2013. Read More

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http://dx.doi.org/10.1016/j.rboe.2017.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205024PMC
February 2018
3 Reads

Predictors of femoral shortening for pediatric developmental hip dysplasia surgery: an observational study in 435 patients.

Authors:
Nabil Alassaf

Patient Saf Surg 2018 19;12:29. Epub 2018 Oct 19.

Department of orthopaedic surgery, King Fahad Medical City, P.O.BOX 59046, Riyadh, 11525 Kingdom of Saudi Arabia.

Background: Open reduction of the congenitally dislocated hip may not be possible without femoral shortening. The goal of this study is to develop a prognostic prediction model for the need of femoral shortening in children undergoing anterior open reduction for the treatment of developmental dysplasia of the hip (DDH). The secondary objective was to determine if femoral shortening influences the risk of adverse events. Read More

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https://pssjournal.biomedcentral.com/articles/10.1186/s13037
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http://dx.doi.org/10.1186/s13037-018-0176-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194737PMC
October 2018
3 Reads

Effects of  transplantation of FGF-2-transfected MSCs and XACB on TNF-α expression with avascular necrosis of the femoral head in rabbits.

Biosci Rep 2018 Oct 30. Epub 2018 Oct 30.

Department of Orthopedics and Trauma, The affiliated hospital of Guizhou Medical University, Gui Yang, 55000, China.

Objective: This study aimed to investigate the effect of the transplantation of basic fibroblast growth factor (FGF-2) gene-transfected mesenchymal stem cells (MSCs) and xenogeneic antigen-cancellous bone (XACB) on tumor necrosis factor-α (TNF-α) expression with avascular necrosis of the femoral head (ANFH) in rabbits.

Methods: The models of steroid-induced osteonecrosis in rabbits were randomly divided into five groups: A (model), B (XACB), C (XACB + MSCs), D (XACB + MSCs + LV), and E (XACB + MSCs + LV-FGF-2) groups. The therapeutic effect was evaluated by H&E staining. Read More

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http://dx.doi.org/10.1042/BSR20180765DOI Listing
October 2018
8 Reads
2.640 Impact Factor

Outcomes for core decompression with multiple drilling of the osteonecrosis of the femoral head in patients with solid organ transplantation.

Eklem Hastalik Cerrahisi 2018 Dec;29(3):159-64

Department of Orthopedics and Traumatology, Başkent University, Faculty of Medicine, 06490, Bahçelievler, Ankara, Turkey.

Objectives: This study aims to investigate the clinical and radiological outcomes of core decompression surgery performed with multiple drilling in solid organ transplantation patients with osteonecrosis of femoral head (ONFH) and evaluate the effectiveness of this procedure in regard to duration of corticosteroid use and stage of osteonecrosis.

Patients And Methods: A total of 22 solid organ transplantation (kidney, liver or heart) patients (14 males, 8 females; mean age 43.3 years; range, 23 to 67 years) who were scheduled to undergo core decompression surgery with multiple drilling for ONFH were evaluated. Read More

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http://dx.doi.org/10.5606/ehc.2018.61348DOI Listing
December 2018
3 Reads

Increased Hip Intracapsular Pressure Decreases Perfusion of the Capital Femoral Epiphysis in a Skeletally Immature Porcine Model.

J Pediatr Orthop 2018 Oct 29. Epub 2018 Oct 29.

Children's Orthopaedics of Atlanta, Atlanta, GA.

Background: Increased intracapsular hip pressure is thought to be one of the possible etiologies of femoral head avascular necrosis after intra-articular proximal femoral fractures or acute slipped capital femoral epiphysis. The purpose of this study was to evaluate the relationship between intra-articular hip pressure (IAP) and epiphyseal perfusion pressure (EPP), and its dependency on skeletal maturity using a porcine model.

Methods: Seven female Yorkshire-hybrid pigs were used to study the direct relationship between IAP and EPP. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001284DOI Listing
October 2018
2 Reads

Femur neck fracture in young adults, is it really an urgent surgery indication: retrospective clinical study.

Pan Afr Med J 2018 12;30:112. Epub 2018 Jun 12.

Dr Lutfi Kirdar Kartal Training and Research Hospital, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

Introduction: Femur neck fracture comprises a significant part of intracapsular femur fracture in the intracapsular area of proximal femur and it is mostly seen in elder people. However, these kinds of fractures may be seen in young adults. The present study aims to search factors that affect femoral neck fractures in young adults after surgery carried out by internal determination method. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.112.13643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195237PMC
November 2018
2 Reads

Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 2: Alcohol-Associated Osteonecrosis.

J Arthroplasty 2019 Jan 22;34(1):169-174.e1. Epub 2018 Sep 22.

Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Although alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH) and its prevalence reportedly ranges from 20% to 45%, there are no unified classification criteria for this subpopulation. In 2015, Association Research Circulation Osseous decided to develop classification criteria for alcohol-associated ONFH.

Methods: In June of 2017, Association Research Circulation Osseous formed a task force to conduct a Delphi survey. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08835403183078
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http://dx.doi.org/10.1016/j.arth.2018.09.006DOI Listing
January 2019
14 Reads

Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 1: Glucocorticoid-Associated Osteonecrosis.

J Arthroplasty 2019 Jan 22;34(1):163-168.e1. Epub 2018 Sep 22.

Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Glucocorticoid usage, a leading cause of osteonecrosis of the femoral head (ONFH), and its prevalence was reported in 25%-50% of non-traumatic ONFH patients. Nevertheless, there have been no unified criteria to classify glucocorticoid-associated ONFH (GA-ONFH). In 2015, the Association Research Circulation Osseous addressed the issue of developing a classification scheme. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08835403183078
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http://dx.doi.org/10.1016/j.arth.2018.09.005DOI Listing
January 2019
17 Reads