7,250 results match your criteria Female Urinary Organs


SARS-CoV-2 identification in lungs, heart and kidney specimens by transmission and scanning electron microscopy.

Eur Rev Med Pharmacol Sci 2020 05;24(9):5186-5188

Department of Excellence of Biomedical Sciences and Public Health, University "Politecnica delle Marche" of Ancona, Ancona, Italy.

From two COVID-19-related deaths, samples of lung, heart and kidney were collected and processed for Transmission and Scanning Electron Microscopy (TEM and SEM) with the aim of identifying the virus. Virions of SARS-CoV-2 were found in all tissues by TEM and SEM, corroborating the hypothesis that the virus enters the cells of different organs. This is the first report identifying SARS-CoV-2 in different human tissues by TEM and SEM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_202005_21217DOI Listing

Anatomy of the female pelvic nerves: a macroscopic study of the hypogastric plexus and their relations and variations.

J Anat 2020 May 19. Epub 2020 May 19.

Institute of Anatomy, University of Bern, Bern, Switzerland.

The autonomic nerves of the lesser pelvis are particularly prone to iatrogenic lesions due to their exposed position during manifold surgical interventions. Nevertheless, the cause of rectal and urinary incontinence or sexual dysfunctions, for example after rectal cancer resection or hysterectomy, remains largely understudied, particularly with regard to the female pelvic autonomic plexuses. This study focused on the macroscopic description of the superior hypogastric plexus, hypogastric nerves, inferior hypogastric plexus, the parasympathetic pelvic splanchnic nerves and the sympathetic fibres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/joa.13206DOI Listing

Patient preparation and image quality in female pelvic MRI: recommendations revisited.

Eur Radiol 2020 Apr 30. Epub 2020 Apr 30.

Department of Radiology, Kantonsspital Baden, Im Ergel 5, 5404, Baden, Switzerland.

Objectives: To assess whether with recent MR technology current patient preparation literature recommendations for female pelvic MRI are still valid and how they are influencing the position of the female pelvic organs, image quality, and diagnostic confidence.

Methods: This prospective study was performed in two centres. The effects of bladder filling (empty, moderate, full; n = 26), fasting, saturation band (n = 25), and menstrual cycle (n = 25) were assessed in healthy subjects in centre 1, while the effect of intravenous glucagon application was evaluated in 20 patients with benign conditions in centre 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-020-06869-8DOI Listing

Assessment of Patient Absorbed Radiation Dose during Hysterosalpingography: A Pilot Study in Southwest Nigeria.

J Biomed Phys Eng 2020 Apr 1;10(2):131-140. Epub 2020 Apr 1.

PhD, Department of Physics and Engineering Physics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

Background: Hysterosalpingography (HSG) is an indispensable tool for diagnosing infertility in females. The procedure exposes female reproductive organs to ionizing radiation as the genitals are irradiated during the process. Investigating patient absorbed dose during the procedures is essential for effective radiological protection of the patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31661/jbpe.v0i0.1054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166218PMC

A Mislocated Intrauterine Device Migrating to the Urinary Bladder: An Uncommon Complication Leading to Stone Formation.

Case Rep Urol 2020 7;2020:2091915. Epub 2020 Apr 7.

Department of Urology, Military Hospital of First Instruction of Tunis, University of Tunis El Manar, Tunisia.

Intrauterine devices are a popular form of reversible contraception among women. Its administration can lead to some uncommon but serious complications such as perforation leading to its migration into adjacent organs. Like any foreign body, the presence of an IUD in the bladder can result in stone formation due to its lithogenic potential. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/2091915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166296PMC

Laparoscopic sacrocolpopexy plus ventral rectopexy as combined treatment for multicompartment pelvic organ prolapse.

Tech Coloproctol 2020 Jun 13;24(6):573-584. Epub 2020 Apr 13.

UOSA di Proctologia, Dipartimento di chirurgia generale, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Pelvic organ prolapse (POP) is a dynamic disorder that affects the entire pelvic diaphragm. POP may often involve multiple organs. Abdominal sacrocolpopexy is considered the gold standard to treat female anterior and apical prolapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10151-020-02199-5DOI Listing

Microenergy acoustic pulses induced myogenesis of urethral striated muscle stem/progenitor cells.

Transl Androl Urol 2019 Oct;8(5):489-500

Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.

Background: Stress urinary incontinence (SUI) is a common disorder with high prevalence in women across their life span, but there are no non-surgical curative options for the condition. Stem cell-based therapy, especially endogenous stem cell therapy may be a potential treatment method for SUI. The aims of this study are to identify, isolate, and assay the function of urethral striated muscle derived stem/progenitor cells (uMDSCs) and to assess uMDSC response to microenergy acoustic pulses (MAP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tau.2019.08.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842786PMC
October 2019

Clinical translation of F-fluoropivalate - a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers.

Eur J Nucl Med Mol Imaging 2020 Mar 2. Epub 2020 Mar 2.

Department of Surgery and Cancer, Imperial College London, GN1 Commonwealth Building, Hammersmith Hospital, DuCane Rd, London, W12 0NN, UK.

Background: Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including C-acetate, and F-FAC (2-F-fluoroacetate), have previously been used to study short-chain fatty acid (SCFA) metabolism. We developed F-fluoropivalate (F-FPIA; 3-F-fluoro-2,2-dimethylpropionic acid) bearing a gem-dimethyl substituent to assert metabolic stability for studying SCFA metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-020-04724-yDOI Listing

Prenatal hypoxia increases susceptibility to kidney injury.

PLoS One 2020 21;15(2):e0229618. Epub 2020 Feb 21.

Department of Pediatrics, Division of Nephrology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Prenatal hypoxia is a gestational stressor that can result in developmental abnormalities or physiological reprogramming, and often decreases cellular capacity against secondary stress. When a developing fetus is exposed to hypoxia, blood flow is preferentially redirected to vital organs including the brain and heart over other organs including the kidney. Hypoxia-induced injury can lead to structural malformations in the kidney; however, even in the absence of structural lesions, hypoxia can physiologically reprogram the kidney leading to decreased function or increased susceptibility to injury. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229618PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034911PMC

[Comparison between Stump Cylinder and custom mold, effect of the shape of the applicator on the dose distribution].

Cancer Radiother 2020 Apr 13;24(2):106-113. Epub 2020 Feb 13.

École doctorale des sciences et technologies, campus Rafik Hariri, université Libanaise, Hadat, Liban. Electronic address:

Purpose: The purpose of this study was to compare the efficacy of two applicators used in high dose rate vaginal brachytherapy. The first is the Stump Cylinder used in the "brachycenter" department at the Middle East Institute of Health in Lebanon and the second is the custom mold used in the radiotherapy department at Tenon Hospital in France.

Materials And Method: A comparison of the clinical target volume and the doses received by the rectum and bladder was performed in order to determine the best method of treatment and to optimize the dose distribution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canrad.2019.10.002DOI Listing

Can Botulinum Toxin A Play A Role In Treatment Of Chronic Pelvic Pain Syndrome In Female Patients?-Clinical and Animal Evidence.

Toxins (Basel) 2020 Feb 10;12(2). Epub 2020 Feb 10.

Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Gung Road, Taipei 114, Taiwan.

Chronic pelvic pain (CPP) is defined as chronic pain and inflammation in the pelvic organs for more than six months. There are wide ranges of clinical presentations, including pelvic pain, painful intercourse, irritable bowel syndrome, and pain during urinating. Chronic pelvic pain syndrome (CPPS) is a subdivision of CPP, and the pain syndrome may be focused within a single organ or more than one pelvic organ. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins12020110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076794PMC
February 2020

[Cancers of urinary system, prevalence, demographic].

Urologiia 2019 12(6):74-77

Isfahan Kidney Transplantation Research Center.

Background: The aim of this study was to clarify period prevalence (PP) and incidence associated to urinary system cancers in Isfahan Province/Iran.

Method: s: Data from 2011 to 2015 was obtained from the Isfahan Cancer Registry. The location of cancers was distinguished by the related established topography code (C64-C68). Read More

View Article

Download full-text PDF

Source
December 2019

Comparative histology of wild-type and p53-deficient medaka (Oryzias latipes): nephrotoxic effect of ultraviolet A radiation.

Photochem Photobiol Sci 2020 Feb;19(2):261-273

Zoology department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.

Ultraviolet radiation is an ecological factor that directly affects terrestrial organisms through suppression of immunity or damage to internal organs. The present study assessed the effects of ultraviolet A (UVA) radiation on the kidneys of both wild-type (WT) and p53-deficient medaka (Oryzias latipes) and evaluated which strain was more resistant to the effects of UVA. Fish were divided into four groups: control group 1 (Cwt and Cp53), kept for 3 days without UVA exposure; group 2 (1wt and 1p53), fish exposed daily to UVA for 1 h day-1 for 3 days; group 3 (2wt and 2p53), fish exposed daily to UVA for 2 h day-1 for 3 days; and group 4 (3wt and 3p53), fish exposed daily to UVA for 3 h day-1 for 3 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9pp00236gDOI Listing
February 2020
2.267 Impact Factor

Systemic distribution of progesterone receptor subtypes in human tissues.

J Steroid Biochem Mol Biol 2020 May 25;199:105599. Epub 2020 Jan 25.

Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:

Progesterone receptor (PR) is expressed in a wide variety of human tissues, including both reproductive and non-reproductive tissues. Upon binding to the PR, progesterone can display several non-reproductive functions, including neurosteroid activity in the central nervous system, inhibition of smooth muscle contractile activity in the gastrointestinal tract, and regulating the development and maturation of the lung. PR exists as two major isoforms, PRA and PRB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2020.105599DOI Listing

Complications and 5-year survival after radical resections which include urological organs for locally advanced and recurrent pelvic malignancies: analysis of 646 consecutive cases.

Tech Coloproctol 2020 Feb 6;24(2):181-190. Epub 2020 Jan 6.

Colorectal Division of Cancer Surgery, Peter MacCallum Cancer Centre, 350 Grattan Street, Melbourne, VIC, 3000, Australia.

Background: Extensive multi-visceral resection, including components of the urinary tract, is often required to achieve clear resection margins, which is now well established as a key predictor of long-term survival for locally advanced pelvic tumours. The aims of this study were to analyse major morbidity and factors predicting complications and long-term outcomes following a urological procedure within extended radical resections.

Methods: Data were collected from prospective databases at two high-volume institutions specialising in extended radical resections for locally advanced and recurrent pelvic malignancies between 1990 and 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10151-019-02141-4DOI Listing
February 2020

In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats.

Int Neurourol J 2019 Dec 31;23(4):277-286. Epub 2019 Dec 31.

Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Purpose: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5213/inj.1938102.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944793PMC
December 2019

Outcome of Kidney Transplantation Using Organs From Brain-dead Donors Older Than 75 Years.

Transplant Proc 2020 Jan - Feb;52(1):119-126. Epub 2019 Dec 31.

Department of Surgery, University Hospital Knappschaftskrankenhaus Bochum, Ruhr-University Bochum, Bochum, Germany. Electronic address:

Purpose: We investigated whether older donor kidneys aged >75 years have acceptable long-term function and if recipients can benefit sufficiently from the transplantation.

Methods: This single-center study retrospectively analyzed patient data from 217 deceased donor kidney transplants performed between 1998 and 2014 as part of the Eurotransplant Senior Program, where the organ donors were ≥65 years old. Depending on donor age, the groups "older donors" (OD; n = 161) and "very old donors" (VOD; n = 56) received transplants from donors aged 65 to 75 years and >75 years, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.11.013DOI Listing

Implications of applicators orientations on bladder, and rectal doses in gynecological mHDR brachytherapy: A retrospective analysis of reproducibility in multi-fractionated regimen.

J Cancer Res Ther 2019 Oct-Dec;15(6):1345-1351

Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Introduction: Variation of doses due to positional uncertainties of applicators based on orthogonal radiograph has been evaluated by several researchers. The present study has analyzed the various possibilities of special alterations of applicator placements in intracavitary brachytherapy (ICBT) and its impact on the dose to target volume, rectum, and bladder. An innovative approach has been suggested to quantify and utilize the special coordinates for reproducibility of applicator based on the pelvic bone landmark. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_1158_16DOI Listing

Interfraction physical dose variations in high-dose-rate brachytherapy for carcinoma cervix based on computed tomography image dataset to find the compatibility of the first fraction plan to treat successive fractions.

J Cancer Res Ther 2019 Oct-Dec;15(6):1304-1308

Department of Radiotherapy, Gandhi Medical College, Bhopal, Madhya Pradesh, India.

Context: Due to limited resources and/or affordability by majority of the patients, many centers in low- and middle-income countries are still not able to adapt three-dimensional image-based brachytherapy planning in their routine practice.

Aim: The aim of the study was to see the feasibility of using computed tomography (CT)-based plan of the first fraction to treat successive fractions of intracavitary brachytherapy based on the estimation of the physical dosimetric differences between successive applications.

Materials And Methods: CT image-based brachytherapy plans of 38 patients who received three insertions of intracavitary application with high-dose-rate brachytherapy have been analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_475_19DOI Listing

Thallium exposure at low concentration leads to early damage on multiple organs in children: A case study followed-up for four years.

Environ Pollut 2020 Mar 21;258:113319. Epub 2019 Nov 21.

Center of Laboratory Medicine, Chongqing Prevention and Treatment Center for Occupational Diseases, Chongqing, People's Republic of China; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College of Chongqing University, Chongqing, People's Republic of China. Electronic address:

Thallium (TI) is one of the most toxic heavy metals and priority pollutant metals. The emerging TI environmental pollution worldwide has posed a great threat to human health. However, based on the World Health Organization (WHO), the risk and severity of adverse health effects of TI in the range of 5-500 μg/L are uncertain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.113319DOI Listing

Eight weeks of treatment with nandrolone decanoate in female rats promotes disruption in the redox homeostasis and impaired renal function.

Life Sci 2020 Feb 24;242:117227. Epub 2019 Dec 24.

Department of Pharmaceutical Sciences, University of Vila Velha - UVV, Vila Velha, Espírito Santo, Brazil. Electronic address:

Introduction: Misuse of AAS is emergent among both genders, however, few studies were performed evaluating AAS effects on female body and none evaluate the impact of nandrolone decanoate (ND) in renal function.

Aim: Determine the effects of chronic treatment with ND on kidney function of female rats and evaluate the influence of oxidative stress on it.

Material And Methods: Female rats were separated into two groups (n = 8 each), the treated group (DECA), which received ND at a dose of 20 mg/kg/week (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.117227DOI Listing
February 2020

Impact of a Changing Population Structure and Clustering of Cancer in Prostate Cancer Patients Depending on a First-Degree Family History.

Urol Int 2020 20;104(3-4):222-229. Epub 2019 Dec 20.

Department of Urology, Faculty of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany,

Introduction: In the last century, there have been major changes within the population structure in Germany. The aim of this study was to determine the impact of a changing population structure on identification of familial prostate cancer (PCa), and to investigate how many and which types of other cancers have occurred in patients and their first-degree relatives.

Materials And Methods: A total of 19,540 patients were evaluated in a prospectively collected PCa family database and divided into four birth cohorts: 1925-1934 (cohort A), 1935-1944 (cohort B), 1945-1954 (cohort C), and 1955-1964 (cohort D). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000504789DOI Listing
December 2019

Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma.

Int Braz J Urol 2020 Jan-Feb;46(1):26-33

Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

Purpose: Clear cell papillary (CCP) renal cell carcinoma (RCC) is a new subtype of RCC that was formally recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia in 2013. Subsequently, CCP RCC was added to the 2016 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs. In this study, we retrospectively investigated the computed tomography (CT) findings of pathologically diagnosed CCP RCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0716DOI Listing
February 2020
0.956 Impact Factor

Clinical Manifestation, Distribution, and Drug Resistance of Pathogens Among Abdominal Solid Organ Transplant Recipients With Klebsiella pneumoniae Infections.

Transplant Proc 2020 Jan - Feb;52(1):289-294. Epub 2019 Dec 16.

Department of Transplant Surgery, the Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:

Background: A Klebsiella pneumoniae infection is a life-threatening disease among abdominal solid organ transplant (ASOT) recipients. The objectives of our present work are to investigate the distribution and drug resistance of pathogens, and clinical manifestation among ASOT recipients suffering from K pneumoniae infections.

Methods: The medical records of 53 ASOT recipients with 63 episodes of K pneumoniae infections from October 1, 2013 to June 1, 2019 were reviewed according to the Declaration of Helsinki and the Declaration of Istanbul. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.11.023DOI Listing

Salt intake assessed by spot urine on physical examination in Hunan, China.

Asia Pac J Clin Nutr 2019 ;28(4):845-856

Department of Health Management, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background And Objectives: Excessive salt intake is a major public health problem in several countries, especially in China. However, few people are aware of their salt intake. The purpose of this study is to carry out salt intake test in routine physical examination, and to explore the salt intake of different populations and their correlation with diet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6133/apjcn.201912_28(4).0022DOI Listing

Laparoscopic Allograft Spacer Placement to Minimize Bowel Dose During Re-irradiation with Interstitial Brachytherapy.

Cureus 2019 Oct 22;11(10):e5958. Epub 2019 Oct 22.

Radiation Oncology, Houston Methodist Hospital, Houston, USA.

In primary or re-irradiation of gynecologic malignancies, achieving optimal dosimetry with adjacent normal tissue becomes challenging. Surgical spacers are tissue-equivalent materials placed within the patient to protect organs at risk from long-term radiation effects and are commonly used in prostate cancer. We report the use of an allograft mesh to protect adhesed bowel from high-dose radiation for definitive treatment of recurrent endometrial cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.5958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863581PMC
October 2019

Ultrasonographic appearance of the coelomic cavity organs in healthy veiled chameleons (Chamaeleo calyptratus) and panther chameleons (Furcifer pardalis).

Vet Radiol Ultrasound 2020 Jan 3;61(1):58-66. Epub 2019 Dec 3.

Fundació Hospital Clínic Veterinari. Carrer de l'Hospital, Bellaterra (Cerdanyola del Vallès), Barcelona, Spain.

Veiled chameleons (Chamaeleo calyptratus) and panther chameleons (Furcifer pardalis) are the most popular chameleons over the world, and consequently, two of the most frequent species presenting to veterinary practices. However, published studies on normal ultrasonographic anatomy for these lizards are currently lacking. The objectives of this prospective anatomic study were to develop an ultrasound protocol for evaluation of the coelomic cavity in these species and describe the normal ultrasonographic anatomy of the coelomic organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vru.12820DOI Listing
January 2020

Retroperitoneal Liposarcoma on 99mTc-DTPA Renal Scintigraphy.

Clin Nucl Med 2020 Feb;45(2):129-130

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

Retroperitoneal liposarcoma is usually large and can press on other organs. We report a case of a 66-year-old woman with a history of retroperitoneal liposarcoma resection who presented to the emergency department with abdominal pain. Ultrasonography revealed a large abdominal mass with renal displacement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002854DOI Listing
February 2020

Implementation of intensity-modulated radiotherapy and comparison with three-dimensional conformal radiotherapy in the postoperative treatment of cervical cancer.

J BUON 2019 Sep-Oct;24(5):2028-2034

Department of Radiotherapy, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Purpose: Within implementation of intensity-modulated radiotherapy (IMRT) in the postoperative irradiation of cervical cancer we evaluated and compared IMRT and three-dimensional conformal radiotherapy (3DCRT) dosimetric parameters for target volumes and organs at risk (OAR).

Methods: We randomized 95 patients with cervical cancer, UICC stage I-III, in groups depending of the type of external beam postoperative radiotherapy. Forty-five patients were treated with IMRT and 50 with 3DCRT. Read More

View Article

Download full-text PDF

Source

Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment.

Food Chem 2020 Apr 7;310:125869. Epub 2019 Nov 7.

Department of Microbiology & Fermentation Technology, CSIR-Central Food Technological Research Institute, Mysuru 570 020, Karnataka, India; Academy of Scientific and Innovative Research, CSIR-Central Food Technological Research Institute, Mysuru 570 020, Karnataka, India. Electronic address:

Talaromyces purpureogenus CFRM02 pigments are non-toxic to Artemia franciscana. Further, in acute toxicity study, single dose (50, 300, 1000 and 2000 mg/kg body weight) pigment was administered to female Wistar rats. After 14 days, no evidence of adverse effect on body weight, mortality and clinical signs were observed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2019.125869DOI Listing

Structural and Functional Bases of Genitourinary Syndrome of Menopause.

Bull Exp Biol Med 2019 Nov 23;168(1):113-117. Epub 2019 Nov 23.

Institute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.

We performed a comprehensive clinical and morphological examination of 70 menopausal patients aged 42-62 years with dysuria and chronic pelvic pain. Assessment of the bladder and vaginal microcirculation by laser Doppler flowmetry in menopausal patients with genitourinary syndrome revealed reduced (by 12-65%) microcirculation parameters. Analysis of the quantitative and qualitative composition of the bacterial microflora of the urethra and vagina revealed abnormalities of microbiota of varying severity, which can be the cause of infectiousinflammatory processes in the pelvic organs leading to chronic pelvic pain syndrome and incontinence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10517-019-04660-4DOI Listing
November 2019

[Use of synthetic slings and mesh implants in the treatment of female stress urinary incontinence and prolapse : Statement of the Working Group on Urological Functional Diagnostics and Female Urology of the Academy of the German Society of Urology].

Urologe A 2020 Jan;59(1):65-71

Kontinenzzentrum Südwest, Schwarzwald-Baar Klinikum Villingen-Schwenningen, Villingen-Schwenningen, Deutschland.

Due to a safety alert issued by the US Food and Drug Administration (FDA) in 2011 for transvaginal mesh implants to treat female prolapse as a result of numerous reports of complications such as infection, chronic pain, dyspareunia, vaginal erosion, shrinkage and erosion into other organs nearly all industrial products have been withdrawn from the market in the meantime. The United Kingdom, Australia, and New Zealand extended warnings and prohibitions even on the implantation of midurethral slings (TVT, TOT). In view of these current international controversies regarding the use of implanted materials for the treatment of stress incontinence and prolapse and the lack of clear guidelines for the use of biomaterials, the opinion of the Working Group on Urological Functional Diagnostics and Female Urology should provide clarity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00120-019-01074-yDOI Listing
January 2020

[PREECLAMPSIA: PATHOGENESIS AND MECHANISMS BASED THERAPEUTIC APPROACHES].

Harefuah 2019 Nov;158(11):742-747

Department of Physiology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-IIT.

Introduction: Preeclampsia is a serious complication of pregnancy affecting 3-8% of all pregnancies. It increases the morbidity and mortality of both the fetus and the pregnant woman, especially in developing countries. It deleteriously affects several vital organs, including the kidney, heart, liver, brain, and lung. Read More

View Article

Download full-text PDF

Source
November 2019

Cyanide concentrations in blood and tissues of fire victims.

Leg Med (Tokyo) 2019 Nov 25;41:101628. Epub 2019 Oct 25.

Department of Legal Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikata-cho 2-5-1, Kita-ku, Okayama 700-8558, Japan. Electronic address:

Cyanide poisoning has been regarded to contribute the fatal outcome in fire victims. The toxicity of inhaled hydrogen cyanide (HCN) at the cellular level was evaluated considering the impact of methemoglobin (MetHb) produced by fire gases. Cyanide (CN) concentrations and total hemoglobin contents were measured in right heart blood (RHB) and seven organs/tissues (basal ganglia, brain stem, heart, lung, liver, kidney and psoas muscle) collected from 20 fire fatalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.legalmed.2019.101628DOI Listing
November 2019

MRI of the Male Pelvic Floor.

Radiographics 2019 Nov-Dec;39(7):2003-2022

From the Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Medical Center North, 1161 21st Ave South, CCC1121, Nashville, TN 37232 (J.L., K.M.S., S.S.A.); Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (G.K.); Department of Radiology, Faculty of Medicine, Cairo University Hospitals, Cairo, Egypt (R.F.E.); Department of Radiology, Montefiore Medical Center, Bronx, NY (V.C.); Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah (J.O.); Department of Radiology, South Nassau Communities Hospital, Oceanside, NY (A.S.); and Department of Diagnostic and Interventional Radiology, University of Texas Health Science Center at Houston, Houston, Tex (V.S.T.).

The pelvic floor is a complex structure that supports the pelvic organs and provides resting tone and voluntary control of the urethral and anal sphincters. Dysfunction of or injury to the pelvic floor can lead to gastrointestinal, urinary, and sexual dysfunction. The prevalence of pelvic floor disorders is much lower in men than in women, and because of this, the majority of the published literature pertaining to MRI of the pelvic floor is oriented toward evaluation of the female pelvic floor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/rg.2019190064DOI Listing
November 2019

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs.

Front Pharmacol 2019 16;10:1218. Epub 2019 Oct 16.

National Engineering Laboratory of High Level Expression in Mammalian Cells, Lunan Pharmaceutical Group Co. Ltd., Linyi, China.

Our previous studies have investigated the systematic pharmacokinetic characteristics, biological activities, and toxicity of arctigenin. In this research, the potential toxicities of arctigenin in beagle dogs were investigated repeated 28-day subcutaneous injections. Beagle dogs were randomly divided into control, vehicle [polyethylene glycol (PEG)], and arctigenin 6, 20, 60 mg/kg treated groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.01218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807677PMC
October 2019
1 Read

Widespread basal cytochrome P450 expression in extrahepatic bovine tissues and isolated cells.

J Dairy Sci 2020 Jan 31;103(1):625-637. Epub 2019 Oct 31.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824. Electronic address:

Periparturient cattle face increased risk of both metabolic and infectious diseases. Factors contributing to this predisposition include oxidized polyunsaturated fatty acids, also known as oxylipids, whose production is altered during the periparturient period and in diseased cattle. Alterations in the production of oxylipids derived from cytochrome P450 (CYP450) enzymes are over-represented during times of increased disease risk and clinical disease, such as mastitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3168/jds.2019-17071DOI Listing
January 2020

miR-146b-5p has a sex-specific role in renal and cardiac pathology in a rat model of chronic kidney disease.

Kidney Int 2019 Dec 16;96(6):1332-1345. Epub 2019 Aug 16.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:

Chronic kidney disease presents a complex and distinct pathological landscape in men and women, yet this difference is poorly understood. microRNAs are powerful molecular regulators of pathophysiology in the kidney and other organs. We previously reported a significant upregulation of miR-146b-5p in the 5/6 nephrectomy rat model of chronic kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2019.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941490PMC
December 2019

Contraceptive efficacy of sperm agglutinating factor from Staphylococcus warneri, isolated from the cervix of a woman with inexplicable infertility.

Reprod Biol Endocrinol 2019 Oct 27;17(1):85. Epub 2019 Oct 27.

Department of Microbiology, South Campus, Basic Medical Science (Block I), Panjab University, Sector 25, Chandigarh, 160014, India.

Background: Voluntary control of fertility is of paramount importance to the modern society. But since the contraceptive methods available for women have their limitations such as urinary tract infections, allergies, cervical erosion and discomfort, a desperate need exists to develop safe methods. Vaginal contraceptives may be the answer to this problem, as these are the oldest ways of fertility regulation, practiced over the centuries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12958-019-0531-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815424PMC
October 2019

Human Radiation Dosimetry for Orally and Intravenously Administered F-FDG.

J Nucl Med 2020 Apr 18;61(4):613-619. Epub 2019 Oct 18.

Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

Intravenous access is difficult in some patients referred for F-FDG PET imaging. Extravasation at the injection site and accumulation in central catheters can lead to limited tumor F-FDG uptake, erroneous quantitation, and significant image artifacts. In this study, we compared the human biodistribution and dosimetry for F-FDG after oral and intravenous administrations sequentially in the same subjects to ascertain the dosimetry and potential suitability of orally administered F-FDG as an alternative to intravenous administration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.119.233288DOI Listing

MiR-122-5p and miR-326-3p: Potential novel biomarkers for early detection of cadmium exposure.

Gene 2020 Jan 15;724:144156. Epub 2019 Oct 15.

Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address:

Cadmium is a common environmental and occupational pollutant and can produce toxic effects in a range of organs, especially in kidneys, after long-term exposure. MicroRNAs are ideal candidate biomarkers for various types of disorders, including renal diseases. In this study, we profiled the global miRNA expressions in rat kidneys using miRNA microarrays and found a collection of differentially expressed miRNAs induced by cadmium exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.144156DOI Listing
January 2020
1 Read

Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 2 diabetes:a retrospective study from glucagon stimulation test.

BMC Endocr Disord 2019 Oct 15;19(1):99. Epub 2019 Oct 15.

Division of Metabolism and Biosystemic Science, Department of Internal Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan.

Background: Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon during GST has not been elucidated. We investigated the relationship between Δglucose and clinical parameters including the liver and renal function in type 2 diabetic subjects, since we hypothesized that Δglucose is associated with the liver and renal function reflecting the capacity for gluconeogenesis in the organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12902-019-0428-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792190PMC
October 2019
1 Read

Evaluation of hematogenous spread and ascending infection in the pathogenesis of acute pyelonephritis due to group B streptococcus in mice.

Microb Pathog 2020 Jan 12;138:103796. Epub 2019 Oct 12.

School of Medical Science, and Menzies Health Institute Queensland, Griffith University, Gold Coast, 4222, QLD, Australia. Electronic address:

Group B streptococcus (GBS) causes pyelonephritis in adults but the mechanisms of infection by which GBS infects the kidneys in vivo are unknown. We investigated GBS infection of the kidneys in mice following experimental challenge via the hematogenous route (transient bacteremia model) or transurethral route (bladder infection and cystitis model). Adult female mice were examined for bacterial dissemination to the kidneys and other organ systems at 24-72 h and tissue samples were assessed for histopathological changes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2019.103796DOI Listing
January 2020
1 Read

Alternative pathway androgen biosynthesis and human fetal female virilization.

Proc Natl Acad Sci U S A 2019 10 14;116(44):22294-22299. Epub 2019 Oct 14.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom;

Androgen biosynthesis in the human fetus proceeds through the adrenal sex steroid precursor dehydroepiandrosterone, which is converted to testosterone in the gonads, followed by further activation to 5α-dihydrotestosterone in genital skin, thereby facilitating male external genital differentiation. Congenital adrenal hyperplasia due to P450 oxidoreductase deficiency results in disrupted dehydroepiandrosterone biosynthesis, explaining undervirilization in affected boys. However, many affected girls are born virilized, despite low circulating androgens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1906623116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825302PMC
October 2019

Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease.

Nucl Med Commun 2019 Nov;40(11):1158-1165

Nuclear Medicine Division, Department of Radiology.

Purpose: Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomography (SPECT/CT) with technetium-99m-dimercaptosuccinic acid (Tc-DMSA) in adult patients with SCD and no clinical evidence of renal insufficiency.

Materials And Methods: Twenty-six patients (16 female) aged 23-58 years with SCD and no clinical evidence of renal insufficiency were prospectively studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNM.0000000000001086DOI Listing
November 2019

Parenterial iron sucrose-induced renal preconditioning: differential ferritin heavy and light chain expression in plasma, urine, and internal organs.

Am J Physiol Renal Physiol 2019 12 14;317(6):F1563-F1571. Epub 2019 Oct 14.

The Fred Hutchinson Cancer Research Center, Seattle, Washington.

Experimental data suggest that iron sucrose (FeS) injection, used either alone or in combination with other prooxidants, can induce "renal preconditioning," in part by upregulating cytoprotective ferritin levels. However, the rapidity, degree, composition (heavy vs. light chain), and renal ferritin changes after FeS administration in humans remain to be defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00307.2019DOI Listing
December 2019

Effect of arsenic and/or fluoride gestational exposure on renal autophagy in offspring mice.

Chemosphere 2020 Feb 20;241:124861. Epub 2019 Sep 20.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, 030801, China. Electronic address:

Both arsenic (As) and fluorine (F) are toxic substances widely found in the environment, which threaten to various organs of both human and animals, especially the kidney. In this study, to investigate the individual and combined effects of arsenic (15 mg/L AsO(III)) and fluoride (100 mg/L NaF), arsenic (15 mg/L AsO(III)) and fluoride-arsenic (15 mg/L AsO(III)+100 mg/L NaF) on the renal autophagy during early life, a mouse model of gestationally exposed to As and/or F was established. The results showed that the mRNA expression levels of LC3, LC3I, LC3II, Beclin-1, ULK1, Atg13 and Atg14 were significantly increased with a concomitant decrease in mTOR and Bcl-2 up on individual exposure to As and F rather than in combined (As + F) exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.124861DOI Listing
February 2020
1 Read
3.340 Impact Factor