7,502 results match your criteria Female Urinary Organs


Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany.

Cancers (Basel) 2021 Apr 22;13(9). Epub 2021 Apr 22.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany.

Background: Cancer is the second leading cause of death worldwide and incidence rates for several tumor entities are rising. In addition to a high cancer-specific mortality rate, many cancer patients also suffer from additional comorbidities. Among these, several psychological morbidities have been extensively studied in the past, but findings on the association between cancer and dementia have remained conflicting. Read More

View Article and Full-Text PDF

A sandwich technique for the removal of stone embedded intrauterine devices in the urinary bladder.

Urol Case Rep 2021 Sep 10;38:101599. Epub 2021 Mar 10.

Department of Urology unit-1, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.

A urinary bladder stone in young adults is uncommon. Dislocation of an IUD to adjection organs is a rare condition. We present a case of a 28-year female with a chief complaint of right side pelvis discomfort, off and on with the urinary system. Read More

View Article and Full-Text PDF
September 2021

[A total replacement of the both ureters and urinary bladder by ileal conduit in a woman with contracted bladder and Ormonds disease].

Urologiia 2021 Mar(1):107-111

Department of urology of North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.

A description of the successful surgical treatment of a patient with irreversible changes in both ureters and bladder resulting from a severe form of Ormond's disease and interstitial cystitis, resulting in contracted bladder, is presented. For the first time in clinical practice, a one-stage cystectomy, a bilateral ureterectomy with complete replacement of both ureters and the bladder with two isoperistaltic small bowel segment was performed. The postoperative course was uneventful. Read More

View Article and Full-Text PDF

Visceral pressure stimulator for exploring hollow organ pain: a pilot study.

Biomed Eng Online 2021 Mar 25;20(1):30. Epub 2021 Mar 25.

Center for Advanced Pain Studies, Department of Neuroscience, University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.

Background: The regulation and control of pressure stimuli is useful for many studies of pain and nociception especially those in the visceral pain field. In many in vivo experiments, distinct air and liquid stimuli at varying pressures are delivered to hollow organs such as the bladder, vagina, and colon. These stimuli are coupled with behavioral, molecular, or physiological read-outs of the response to the stimulus. Read More

View Article and Full-Text PDF

How to balance the treatment of stress urinary incontinence among female athletes?

Arch Med Sci 2021 21;17(2):314-322. Epub 2020 Oct 21.

Department of Mother's and Child's Health, Poznań, Poland.

Urinary incontinence in the general population occurs in 7% of non-pregnant women under 39 years old, 17% of those 40 to 59 years old, and 23-32% of those over 60 years old. In athletes the prevalence is higher, especially in high-impact training and gravity sports. Pelvic floor muscles (PFM) have two important roles; they serve as the support for abdominal organs and are crucial for closure of the urethra, vagina and rectum. Read More

View Article and Full-Text PDF
October 2020

Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.

Nat Protoc 2021 04 5;16(4):2023-2050. Epub 2021 Mar 5.

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.

Advanced in vitro kidney models are of great importance to the study of renal physiology and disease. Kidney tubuloids can be established from primary cells derived from adult kidney tissue or urine. Tubuloids are three-dimensional multicellular structures that recapitulate tubular function and have been used to study infectious, malignant, metabolic, and genetic diseases. Read More

View Article and Full-Text PDF

Post-mortem Histopathologic Findings of Vital Organs in Critically Ill Patients with COVID-19.

Arch Iran Med 2021 Feb 1;24(2):144-151. Epub 2021 Feb 1.

Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The scientific evidence concerning pathogenesis and immunopathology of the coronavirus disease 2019 (COVID-19) is rapidly evolving in the literature. To evaluate the different tissues obtained by biopsy and autopsy from five patients who expired from severe COVID-19 in our medical center.

Methods: This retrospective study reviewed five patients with severe COVID-19, confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and imaging, to determine the potential correlations between histologic findings with patient outcome. Read More

View Article and Full-Text PDF
February 2021

Case Report: Recurrent Placental Abruption During Pregnancy in a Patient With Pseudoexstrophy.

Front Med (Lausanne) 2021 26;8:619322. Epub 2021 Jan 26.

Department of Radiology, The First Hospital of China Medical University, Shenyang, China.

Pseudoexstrophy is a rare variant of the exstrophy-epispadias complex, which comprises musculoskeletal defects associated with bladder exstrophy without any urinary tract defects. However, only a few pregnancy complications have been reported in patients with pseudoexstrophy. This report presents the case of a woman with pseudoexstrophy, who survived recurrent placental abruption during the second trimester of her pregnancy. Read More

View Article and Full-Text PDF
January 2021

Classification of deep endometriosis (DE) including bowel endometriosis: From r-ASRM to #Enzian-classification.

Best Pract Res Clin Obstet Gynaecol 2021 Mar 11;71:27-37. Epub 2020 Dec 11.

Scientific Endometriosis Foundation (Stiftung Endometrioseforschung/ SEF), Westerstede, Germany; Department of Gynaecology, Centre for Endometriosis, Hospital St. John of God; Vienna, Austria.

Endometriotic lesions may affect peritoneal and ovarian tissues, cause secondary adhesions, and - in case of deep endometriosis (DE), invade organs such as the urinary bladder, ureters, and bowel. Over decades, several classification systems have been proposed with the rASRM score being the most widely accepted one to date. However, the rASRM classification has certain limitations regarding the description of DE. Read More

View Article and Full-Text PDF

[Age-related changes of the female urethra.]

Adv Gerontol 2020 ;33(5):945-955

Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution «Federal Research Center of Fundamental and Translational Medicine», 2 Akad. Timakov str., Novosibirsk 630117, Russian Federation.

The minimum and maximum indicators of the length, width, area or volume of organs and structures in the lower urinary tract can normally vary up to 2-3 times. With age, at healthy women the absolute and relative length of the urethra, the urethrovesical angle, and the inclination of the urethra do not change. Both smooth and striated muscle tissues, which are part of various departments of the female urethra, undergo atrophy during the aging process. Read More

View Article and Full-Text PDF
February 2021

Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and β-hydroxy β-methylbutyric acid across multiple organs in the pig.

Am J Physiol Endocrinol Metab 2021 03 1;320(3):E629-E640. Epub 2021 Feb 1.

Center for Translational Research in Aging & Longevity, Department of Health & Kinesiology, Texas A&M University. College Station, Texas.

Branched-chain amino acids (BCAA) and their metabolites the branched-chain keto acids (BCKA) and β-hydroxy β-methylbutyric acid (HMB) are involved in the regulation of key signaling pathways in the anabolic response to a meal. However, their (inter)organ kinetics remain unclear. Therefore, branched-chain amino acids (BCAA) [leucine (Leu), valine (Val), isoleucine (Ile)], BCKA [α-ketoisocaproic acid (KIC), 3-methyl-2-oxovaleric acid (KMV), 2-oxoisovalerate (KIV)], and HMB across organ net fluxes were measured. Read More

View Article and Full-Text PDF

Biodistribution and radiation dosimetry of D-isomer of 4-borono-2-[F]fluoro-phenylalanine: A comparative PET/CT study with L-isomer in healthy human volunteers.

Nucl Med Biol 2021 Mar-Apr;94-95:32-37. Epub 2021 Jan 8.

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China. Electronic address:

Introduction: L-isomer of 4-borono-2-F-fluoro-phenylalanine (L-[F]FBPA) was generally applied in clinic for boron neutron capture therapy (BNCT). With radiotracer validation, D-isomer of [F]FBPA (D-[F]FBPA) was found a higher tumor to normal brain tissue ratio (TBR) than its L-isomer on positron emission tomography (PET) in rat brain glioma. The present study was conducted as a first-in-human study to explore the biodistribution and radiation dosimetry of D-[F]FBPA in healthy human volunteers, compared with L-[F]FBPA. Read More

View Article and Full-Text PDF
January 2021

Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [C]Metoclopramide.

Mol Imaging Biol 2021 04 22;23(2):180-185. Epub 2021 Jan 22.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Purpose: To assess in healthy volunteers the whole-body distribution and dosimetry of [C]metoclopramide, a new positron emission tomography (PET) tracer to measure P-glycoprotein activity at the blood-brain barrier.

Procedures: Ten healthy volunteers (five women, five men) were intravenously injected with 387 ± 49 MBq of [C]metoclopramide after low dose CT scans and were then imaged by whole-body PET scans from head to upper thigh over approximately 70 min. Ten source organs (brain, thyroid gland, right lung, myocardium, liver, gall bladder, left kidney, red bone marrow, muscle and the contents of the urinary bladder) were manually delineated on whole-body images. Read More

View Article and Full-Text PDF

DPPG-Based Thermosensitive Liposomes with Encapsulated Doxorubicin Combined with Hyperthermia Lead to Higher Doxorubicin Concentrations in the Bladder Compared to Conventional Application in Pigs: A Rationale for the Treatment of Muscle-Invasive Bladder Cancer.

Int J Nanomedicine 2021 7;16:75-88. Epub 2021 Jan 7.

Department of Urology, Radboud University Medical Center, Nijmegen, the Netherlands.

Purpose: Current treatment options for muscle-invasive bladder cancer (MIBC) are associated with substantial morbidity. Local release of doxorubicin (DOX) from phosphatidyldiglycerol-based thermosensitive liposomes (DPPG-TSL-DOX) potentiated by hyperthermia (HT) in the bladder wall may result in bladder sparing without toxicity of systemic chemotherapy. We investigated whether this approach, compared to conventional DOX application, increases DOX concentrations in the bladder wall while limiting DOX in essential organs. Read More

View Article and Full-Text PDF
January 2021

Ammonia exposure causes the disruption of the solute carrier family gene network in pigs.

Ecotoxicol Environ Saf 2021 Mar 10;210:111870. Epub 2021 Jan 10.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, People's Republic of China. Electronic address:

Ammonia is the main harmful gas in livestock houses. However, the toxic mechanism of ammonia is still unclear. Therefore, we examined the effects of ammonia exposure on different tissues of fattening pigs by histological analysis and transcriptome techniques in this study. Read More

View Article and Full-Text PDF

The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection.

Int J Environ Res Public Health 2021 01 2;18(1). Epub 2021 Jan 2.

School of Mathematics, Harbin Institute of Technology, Harbin 150001, China.

COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs, suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the viral susceptibility of other organs is important for a deeper understanding of viral pathogenesis. Angiotensin-converting enzyme II (ACE2) is the receptor protein of SARS-CoV-2, and TMPRSS2 promotes virus proliferation and transmission. Read More

View Article and Full-Text PDF
January 2021

Seasonal exposure to phthalates and inflammatory parameters: A pilot study with repeated measures.

Ecotoxicol Environ Saf 2021 Jan 19;208:111633. Epub 2020 Nov 19.

State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China. Electronic address:

Exposure to phthalates poses potential to damage multiple organs and system in the body. However, limited data are available regarding effects of seasonal exposure levels of phthalates and indicators reflecting inflammatory response. We designed a pilot study with repeated measures. Read More

View Article and Full-Text PDF
January 2021

Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase-3/9 through pro-oxidant stimulus.

Environ Toxicol 2021 May 4;36(5):958-974. Epub 2021 Jan 4.

Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.

Gestational exposure to environmental pollutants can induce oxidative injury and apoptosis since the fetal organs are sensitively vulnerable to these chemicals. In this work, we have investigated the renal anti-apoptotic efficiency of linseed (LS) against the oxidative stress-mediated upregulation of the fetal apoptosis-related genes following the prenatal intoxication with diesel nanoparticles (DNPs) and/or fenitrothion (FNT). A fifty-six timed-pregnant rats were equally divided to eight groups; control, LS (20% in diet), DNPs (0. Read More

View Article and Full-Text PDF

[Cancer incidence and mortality of kidney and unspecified urinary organs in China, 2015].

Zhonghua Zhong Liu Za Zhi 2020 Dec;42(12):1001-1006

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To estimate cancer incidence and mortality of kidney and unspecified urinary organs in China using cancer registry data in 2015. The cancer registry data from 501 local cancer registries in China were collected, checked and assessed based on the criteria of data quality control of the National Central Cancer Registry of China (NCCRC), and data from 368 registries were qualified for the analysis. Cancer incidence and mortality rates of kidney and unspecified urinary organs stratified by geographical location (eastern, middle, western areas), gender, age groups were calculated. Read More

View Article and Full-Text PDF
December 2020

Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - A scoping review.

Microvasc Res 2021 03 15;134:104123. Epub 2020 Dec 15.

Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, United States. Electronic address:

Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and 2019 that measured blood biomarkers of MVD in three vital organs i.e. Read More

View Article and Full-Text PDF

DIAGNOSIS OF BLUNT TRAUMA OF KIDNEY INJURY WITH INFRARED THERMOMETER METHOD.

Georgian Med News 2020 Oct(307):132-137

1O.O. Bohomolets National Medical University, Kyiv; Ukraine.

Aim - the study of the prescription of injury on the dynamics of changes in temperature indices of the injured kidney tissues in blunt trauma. The material of the study to date are the tissues of the kidneys of 256 male and female persons, aged 20 to 60 years, who died at a known time of trauma and prescription of death in the were subject to autopsy. To address the question of the age of occurrence of kidney damage, we used a modern method of infrared thermometry (using a TH 9100 PMVI-WL Thermo Tracker thermal imager, which is a contactless high-sensitivity infrared camera). Read More

View Article and Full-Text PDF
October 2020

Organ-sparing cystectomy techniques: Functional and oncological outcomes, review and current recommendations.

Arch Esp Urol 2020 12;73(10):961-970

Department of Urology. La Paz University Hospital. Madrid. Spain. Instituto de Investigación Hospital Universitario La Paz (IdiPAZ). Madrid. Spain.

Introduction: With increasing survival from bladder cancer, quality of life, should be one of the main goals following radical cystectomy and bilateral pelvic lymph node dissection (PLND). This techniqueis associated with significant morbidity, which may have a critical effect on quality of life. Concerns about functional outcomes, such as continence, potency, and sexual function in women, play a role in decision making for urologists and younger patients with muscle-invasive bladder cancer. Read More

View Article and Full-Text PDF
December 2020

Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults.

BMJ 2020 12 2;371:m4060. Epub 2020 Dec 2.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Objective: To examine associations between birth defects and cancer from birth into adulthood.

Design: Population based nested case-control study.

Setting: Nationwide health registries in Denmark, Finland, Norway, and Sweden. Read More

View Article and Full-Text PDF
December 2020

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH.

Nat Protoc 2021 01 27;16(1):239-262. Epub 2020 Nov 27.

Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.

Advances in light-sheet and confocal microscopy now allow imaging of cleared large biological tissue samples and enable the 3D appreciation of cell and protein localization in their native organ environment. However, the sample preparations for such imaging are often onerous, and their capability for antigen detection is limited. Here, we describe FLASH (fast light-microscopic analysis of antibody-stained whole organs), a simple, rapid, fully customizable technique for molecular phenotyping of intact tissue volumes. Read More

View Article and Full-Text PDF
January 2021

Pregnant alpha-1-microglobulin (A1M) knockout mice exhibit features of kidney and placental damage, hemodynamic changes and intrauterine growth restriction.

Sci Rep 2020 11 26;10(1):20625. Epub 2020 Nov 26.

Division of Obstetrics and Gynecology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Alpha-1-microglobulin (A1M) is an antioxidant previously shown to be elevated in maternal blood during pregnancies complicated by preeclampsia and suggested to be important in the endogenous defense against oxidative stress. A knockout mouse model of A1M (A1Mko) was used in the present study to assess the importance of A1M during pregnancy in relation to the kidney, heart and placenta function. Systolic blood pressure (SBP) and heart rate (HR) were determined before and throughout gestation. Read More

View Article and Full-Text PDF
November 2020

Medical imaging community outreach program: lesson to students and impact to the community.

J Ultrasound 2020 Nov 25. Epub 2020 Nov 25.

Department of Medical Imaging Sciences, School of Health Sciences, University of Rwanda-College of Medicine and Health Sciences, P.O Box 3286, Kigali, Rwanda.

Background: The community outreach program is one of the main activities of the University of Rwanda, and both staff and students get involved in this tremendous initiative to serve the community free of charge.

Purpose: The main objectives of this community engagement activity were to raise awareness of medical imaging services and abdominal ultrasound screening.

Methods: The project proposal was planned by the Medical Imaging Department, University of Rwanda College of Medicine and Health Sciences, Remera Campus. Read More

View Article and Full-Text PDF
November 2020

Botanical from the medicinal spice, is safe as demonstrated by oral acute and subchronic toxicity investigations.

Heliyon 2020 Nov 9;6(11):e05470. Epub 2020 Nov 9.

Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon.

Linn is a plant used in Cameroon to treat cancer and several other diseases such as urinary tract disorder, fever, stomach-ache and to improve appetite. The methanol extract of has been reported for its antiproliferative activity towards several human cancer cell lines. The aim of this work was to evaluate the acute and subchronic oral toxicities of a methanol extract from fruits on rats. Read More

View Article and Full-Text PDF
November 2020

Feeding Arsenic-Containing Rice Bran to Growing Pigs: Growth Performance, Arsenic Tissue Distribution, and Arsenic Excretion.

Int J Environ Res Public Health 2020 11 17;17(22). Epub 2020 Nov 17.

Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Mississippi State, MS 39762, USA.

This research was conducted to study the growth performance, arsenic (As) tissue distribution, and As excretion of pigs fed As-containing rice bran. Twenty gilts (26.3 kg) were randomly assigned to 3 dietary treatments ( = 6 or 7) with Diets I, II, and III containing 0, 36. Read More

View Article and Full-Text PDF
November 2020

Pessaries (mechanical devices) for managing pelvic organ prolapse in women.

Cochrane Database Syst Rev 2020 11 18;11:CD004010. Epub 2020 Nov 18.

The Warrell Unit, Department of Gynaecology, St Mary's Hospital, Manchester University Foundation NHS Trust, Manchester, UK.

Background: Pelvic organ prolapse is a common problem in women. About 40% of women will experience prolapse in their lifetime, with the proportion expected to rise in line with an ageing population. Women experience a variety of troublesome symptoms as a consequence of prolapse, including a feeling of 'something coming down' into the vagina, pain, urinary symptoms, bowel symptoms and sexual difficulties. Read More

View Article and Full-Text PDF
November 2020

Serological, molecular and bacteriological approaches for detecting Leptospira sp. carrier rams maintained in semiarid conditions.

Acta Trop 2021 Jan 13;213:105759. Epub 2020 Nov 13.

Universidade de São Paulo (USP), Av. Prof. Almeida Prado, 1280, São Paulo, SP 05508-900, Brazil. Electronic address:

Even in the adverse environmental conditions of the semiarid region, leptospires can survive and spread by alternative routes of transmission, such as sexual in ewes, however, there is no data on rams. Thus, the present study aimed to evaluate the use of serological, molecular and microbial tools applied to diagnosis of Leptospira sp. Infection in rams maintained in semiarid conditions. Read More

View Article and Full-Text PDF
January 2021