6,966 results match your criteria Female Urinary Organs


Incidence of gynecological fistula and its surgical treatment: a national registry-based study.

Acta Obstet Gynecol Scand 2019 Mar 19. Epub 2019 Mar 19.

National Treatment Center for Gynecological Fistula, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Introduction: Gynecological fistula (affecting female genital organs) leads to involuntary loss of urine or feces. In industrialized societies, fistulas occur mostly as complications of surgery, radiation therapy, or inflammatory bowel disease. We sought to determine the incidence of gynecological fistula and type of surgical treatment provided in Norway. Read More

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http://dx.doi.org/10.1111/aogs.13611DOI Listing

Urogenital symptoms in mitochondrial disease: overlooked and undertreated.

Eur J Neurol 2019 Mar 18. Epub 2019 Mar 18.

MRC Centre for Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

Background: Bowel symptoms are well documented in mitochondrial disease. However, data concerning other pelvic organs is limited. We have undertaken a large, case-control study to determine the presence of lower urinary tract symptoms (LUTS) and sexual dysfunction in adults with genetically confirmed mitochondrial disease. Read More

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http://dx.doi.org/10.1111/ene.13952DOI Listing

Therapeutic Problems and Pregnancy in a Patient With Infantile Nephropathic Cystinosis: A Case Report.

Transplant Proc 2019 Mar 3;51(2):545-547. Epub 2019 Jan 3.

Department of Transplantation Medicine, Nephrology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Background: Cystinosis is a rare genetic disorder characterized by the abnormal accumulation of cystine in the lysosomes of various tissues and organs leading to their dysfunction. The most common type is the infantile nephropathic cystinosis which without treatment leads to renal failure and before the introduction of cysteamine was the cause of death before puberty.

Case Presentation: A 27-year-old female patient with infantile cystinosis developed end-stage renal disease at the age of 10. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.026DOI Listing

The Deletion of TRPC6 Channels Perturbs Iron and Zinc Homeostasis and Pregnancy Outcome in Mice.

Cell Physiol Biochem 2019 15;52(3):455-467. Epub 2019 Mar 15.

Université Grenoble Alpes, CNRS, CEA, BIG-LCBM, Grenoble, France.

Background/aims: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn). TRPC6 is found throughout the body with high expression levels in the placenta. However, its role in this organ is still to be determined. Read More

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https://www.cellphysiolbiochem.com/Articles/000033/
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http://dx.doi.org/10.33594/000000033DOI Listing
March 2019
3 Reads

Mesh-type reference Korean phantoms (MRKPs) for adult male and female for use in radiation protection dosimetry.

Phys Med Biol 2019 Feb 28. Epub 2019 Feb 28.

Department of Anatomy, Ajou University, Seoul, Korea (the Republic of).

In the present study, to overcome the limitations of the previous voxel-type reference computational phantoms, a pair of new reference Korean phantoms, called mesh-type reference Korean phantoms (MRKPs), were developed for the adult male and female in a high-quality/fidelity mesh format. The developed phantoms include all target and source regions required for effective dose calculation, even micrometer-scale target and source regions of the respiratory and alimentary tract organs, skin, urinary bladder, and eye lens. The developed phantoms, which are in the mesh format, can be directly used in Monte Carlo codes without voxelization. Read More

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http://dx.doi.org/10.1088/1361-6560/ab0b59DOI Listing
February 2019
1 Read

Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".

Medicina (Kaunas) 2019 Feb 18;55(2). Epub 2019 Feb 18.

Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.

In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes. Read More

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http://dx.doi.org/10.3390/medicina55020056DOI Listing
February 2019
2 Reads

Renal shear wave elastography and urinary procollagen type III amino-terminal propeptide (uPIIINP) in feline chronic kidney disease.

BMC Vet Res 2019 Feb 11;15(1):54. Epub 2019 Feb 11.

Department of Veterinary Surgery, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri-Dunant Road, Wangmai, Pathumwan, Bangkok, 10330, Thailand.

Background: Chronic kidney disease (CKD) is one of the most common diseases occurring in cats. It is characterized by renal fibrosis, which is strongly correlated with impairment of renal function. Since renal biopsy is not performed routinely in clinical practice, the non-invasive method of ultrasonographic shear-wave elastography (SWE) was used to determine renal parenchymal stiffness. Read More

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http://dx.doi.org/10.1186/s12917-019-1801-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371591PMC
February 2019
2 Reads

Elastography detected solid organ stiffness increased in patients with acromegaly.

Medicine (Baltimore) 2019 Jan;98(3):e14212

Department of Internal Medicine.

Elastography is a method to examine the increase in solid organs stiffness (SOS), and there is no data in the literature regarding to its use in patients with acromegaly. In this study, we aimed to investigate the change of SOS in patients with acromegaly and to determine the parameters closely related to SOS in same patient groups.We included 40 subjects with acromegaly and 40 healthy control subjects. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0009
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http://dx.doi.org/10.1097/MD.0000000000014212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370059PMC
January 2019
6 Reads

Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.

Nat Commun 2019 01 16;10(1):239. Epub 2019 Jan 16.

Department for Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058, Basel, Switzerland.

Branching patterns and regulatory networks differ between branched organs. It has remained unclear whether a common regulatory mechanism exists and how organ-specific patterns can emerge. Of all previously proposed signalling-based mechanisms, only a ligand-receptor-based Turing mechanism based on FGF10 and SHH quantitatively recapitulates the lung branching patterns. Read More

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http://www.nature.com/articles/s41467-018-08212-8
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http://dx.doi.org/10.1038/s41467-018-08212-8DOI Listing
January 2019
2 Reads

An Autopsy Case Report: Prune Belly Syndrome with Overlapping Presentation of Partial Urorectal Septum Malformation Sequence.

Turk Patoloji Derg 2019 Jan 11. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, Istanbul University, School of Medicine Istanbul, ISTANBUL, TURKEY.

Prune belly syndrome (PBS) is characterized by a classical triad of congenitally absent abdominal muscles, bilateral cryptorchidism, and a malformed urinary tract. Urorectal septum malformation sequence (URSM) is identified with the absence of urogenital and anal openings. This case report describes a 15-week-old female fetus with megacystis, ascites and oligohydramnios in a 19-year-old nulliparous woman. Read More

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http://dx.doi.org/10.5146/tjpath.2018.01440DOI Listing
January 2019
10 Reads

The fundamentals of chronic pelvic pain assessment, based on international continence society recommendations.

Neurourol Urodyn 2018 Aug;37(S6):S32-S38

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

Aims: Chronic pelvic pain (CPP) is defined as a noncyclical pain that has duration of at least 6 months and can lead to decreased quality of life and physical performance. The pain can be attributed to problems in the pelvic organs and/or problems in related systems, and possible psycho-social attributes may contribute to the manifestation. Due to the complex nature, CPP syndromes are multifactorial and the terminology needs to reflect the setting. Read More

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http://doi.wiley.com/10.1002/nau.23776
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http://dx.doi.org/10.1002/nau.23776DOI Listing
August 2018
12 Reads
2.873 Impact Factor

Inflammatory myofibroblastic tumor of urinary bladder with severe hematuria: A Case report and literature review.

Medicine (Baltimore) 2019 Jan;98(1):e13987

Department of Urology, Qilu Hospital of Shandong University, Jinan, China.

Rationale: Inflammatory myofibroblastic tumor (IMT) is a rare intermediate soft tissue tumor. Rarely occurring in the urinary bladder, MTs is composed of myofibroblast differentiated spindle cells and accompanied by numerous inflammatory cells, plasma cells and/or Lymphocytes.

Patient Concerns: A 28-year-old female, with history of 2 cesarean sections 8 years ago and 2 years ago, was admitted to the emergency department for a 7-day ongoing gross hematuria with clots. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0006
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http://dx.doi.org/10.1097/MD.0000000000013987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344176PMC
January 2019
9 Reads

Disseminated canine mold infections.

Authors:
Daniel Elad

Vet J 2019 Jan 30;243:82-90. Epub 2018 Nov 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, Bet Dagan, Israel. Electronic address:

Disseminated canine mold infections are reviewed. Case inclusion criteria were dogs as hosts, two or more non-adjacent organs affected and identification of the etiological agent at least to the genus level. Of the 157 cases identified, 59. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10900233183076
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http://dx.doi.org/10.1016/j.tvjl.2018.11.016DOI Listing
January 2019
6 Reads

Cell Versus Chemokine Therapy Effects on Cell Mobilization to Chronically Dysfunctional Urinary Sphincters of Nonhuman Primates.

Int Neurourol J 2018 Dec 31;22(4):260-267. Epub 2018 Dec 31.

Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA.

Purpose: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs. The goal of this study was to compare the cell mobilizing effects of the chemokine CXCL12 and cell therapy on the urinary sphincter of nonhuman primates (NHP) with chronic intrinsic urinary sphincter dysfunction.

Methods: Either autologous lenti-M-cherry labeled skeletal muscle precursor cells (skMPCs) or CXCL12 were injected directly into the sphincter complex of female NHPs with or without surgery-induced chronic urinary sphincter dysfunction (n=4/treatment condition). Read More

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http://dx.doi.org/10.5213/inj.1836126.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312977PMC
December 2018

Growth of pediatric recipients after renal transplantation from small pediatric deceased donors weighing less than 15 kg.

Pediatr Transplant 2019 02 28;23(1):e13306. Epub 2018 Dec 28.

Department of Organ Transplantation, Changhai Hospital, Second Military Medical University, Shanghai, China.

RTx is currently the best treatment for children with ESRD. This study retrospectively analyzed the outcomes of growth after RTx using the pediatric-to-pediatric allocation strategy and some factors that may affect it. From March 2012 to August 2016, 8 en bloc and 38 single pediatric RTxs were performed at our center using organs from small pediatric deceased donors (weight < 15 kg). Read More

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http://dx.doi.org/10.1111/petr.13306DOI Listing
February 2019
3 Reads
1.630 Impact Factor

The impact of Bacillus subtilis 18 isolated from Tibetan yaks on growth performance and gut microbial community in mice.

Microb Pathog 2019 Mar 21;128:153-161. Epub 2018 Dec 21.

College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China; College of Animals Husbandry and Veterinary Medicine, Tibet Agricultural and Animal Husbandry University, Linzhi, Tibet, 860000, PR China. Electronic address:

The purpose of this study was to evaluate the effects of Bacillus subtilis 18 (BS-18) isolated from free-ranging Tibetan yaks in high altitude regions of Tibet (3600 m) on growth performance and gut microbial community in mice. In this study, mice (15-day-old) were used as an animal model and raised under standard conditions. A total of 20 KM mice were divided equally into two groups: control group (feed and drink freely), experimental group (feed and drink freely + 1 × 10 CFU/day BS-18). Read More

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http://dx.doi.org/10.1016/j.micpath.2018.12.031DOI Listing
March 2019
4 Reads

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity.

Cell Host Microbe 2019 01 20;25(1):113-127.e6. Epub 2018 Dec 20.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address:

Western lifestyle is linked to autoimmune and metabolic diseases, driven by changes in diet and gut microbiota composition. Using Toll-like receptor 7 (TLR7)-dependent mouse models of systemic lupus erythematosus (SLE), we dissect dietary effects on the gut microbiota and find that Lactobacillus reuteri can drive autoimmunity but is ameliorated by dietary resistant starch (RS). Culture of internal organs and 16S rDNA sequencing revealed TLR7-dependent translocation of L. Read More

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http://dx.doi.org/10.1016/j.chom.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377154PMC
January 2019
3 Reads

Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre.

Swiss Med Wkly 2018 12 21;148:w14699. Epub 2018 Dec 21.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.

Background And Aim: Wilson’s disease is an inherited disorder of hepatic copper metabolism, leading to the accumulation of copper in the liver as well as the brain, cornea and other organs. Here, we describe the adult cases of hepatic Wilson’s disease diagnosed at the Division of Gastroenterology and Hepatology of the University Hospital Lausanne, Switzerland between September 2004 and August 2016.

Methods: Clinical manifestations, results of diagnostic tests, management and outcomes of adult patients with hepatic Wilson’s disease were assessed based on standardised medical records. Read More

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http://dx.doi.org/10.4414/smw.2018.14699DOI Listing
December 2018
1 Read

Histological analyses of the Ishii (1981) rat carcinogenicity study of aspartame and comparison with the Ramazzini Institute studies.

Regul Toxicol Pharmacol 2019 Mar 18;102:23-29. Epub 2018 Dec 18.

Intertek Scientific & Regulatory Consultancy, 2233 Argentia Road, Suite 201, Mississauga, Ontario, L5N 2X7, Canada.

Researchers from the Ramazzini Institute have reported that lifespan dosing of rats with aspartame treatment is associated with an increased overall incidence of malignant tumors, including leukemias/lymphomas, transitional cell carcinomas of the renal pelvis/ureter, and malignant schwannomas of the peripheral nerves. Other carcinogenicity studies conducted on aspartame have shown no such carcinogenic potential in any organ system. Additional data to assess the carcinogenic potential of aspartame, especially in relation to the publications of the Ramazzini Institute, were obtained from a third-party histological evaluation of tissues from a carcinogenicity study previously conducted to assess the potential for aspartame to induce tumors of the brain. Read More

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http://dx.doi.org/10.1016/j.yrtph.2018.12.010DOI Listing
March 2019
2 Reads

Bladder cavernous hemangioma after pelvic radiotherapy in a female patient: A case report and literature review.

Int J Surg Case Rep 2018 24;53:479-482. Epub 2018 Nov 24.

Department of Urology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430079, PR China. Electronic address:

Introduction: Hemangiomas are benign tumor formations of capillaries and blood vessels which are commonly found in various organs. However they are extremely rare in urinary bladder accounting for only 0.6% of all urinary bladder tumors. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277215PMC
November 2018
2 Reads

The association between shift work and chronic kidney disease in manual labor workers using data from the Korea National Health and Nutrition Examination Survey (KNHANES 2011-2014).

Ann Occup Environ Med 2018 14;30:69. Epub 2018 Dec 14.

1Department of Occupational & Environmental Medicine, Eulji University Hospital, Daejeon, Republic of Korea 35233.

Objective: Kidneys are organs having a biological clock, and it is well known that the disruption of the circadian rhythm increases the risk of chronic kidney disease (CKD), including the decline of renal and proteinuria. Because shift work causes circadian disruption, it can directly or indirectly affect the incidence of chronic kidney disease. Therefore, the purpose of this study was to investigate the association between shift work and chronic kidney disease using a Korean representative survey dataset. Read More

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http://dx.doi.org/10.1186/s40557-018-0279-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295007PMC
December 2018

Female urethral dilatation (bougierung): a case report.

J Med Case Rep 2018 Dec 19;12(1):382. Epub 2018 Dec 19.

Vivantes Humboldt Clinic, Pelvic Floor and Incontinence Centre, Am Nordgraben 2., 13509, Berlin, Germany.

Background: Primary bladder neck obstruction is a rare clinical entity, reported to be responsible for 2.7-8% of lower urinary tract symptoms. It can lead to various urinary storage and voiding symptoms. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1900-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299518PMC
December 2018
8 Reads

Heteroplasmy Detection of Mitochondrial DNA A3243G Mutation Using Quantitative Real-Time PCR Assay Based on TaqMan-MGB Probes.

Biomed Res Int 2018 13;2018:1286480. Epub 2018 Nov 13.

Chinovo Laboratory, Beijing, China.

A point mutation of mitochondrial DNA (mtDNA) at nucleotide position 3243 A to G (mt.3243A>G) is involved in many common diseases, including maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS). However, the mutant level of mt. Read More

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https://www.hindawi.com/journals/bmri/2018/1286480/
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http://dx.doi.org/10.1155/2018/1286480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260548PMC
March 2019
1 Read

Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice.

Cell Physiol Biochem 2018 11;51(5):2421-2433. Epub 2018 Dec 11.

College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.

Background/aims: Excessive fluoride intake can induce cytotoxicity, DNA damage and cell-cycle changes in many tissues and organs, including the kidney. However, the underlying molecular mechanisms of fluoride-induced renal cell-cycle changes are not well understood at present. In this study, we used a mouse model to investigate how sodium fluoride (NaF) induces cell-cycle changes in renal cells. Read More

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http://dx.doi.org/10.1159/000495899DOI Listing
January 2019
8 Reads

A dosimetry procedure for organs-at-risk in Lu peptide receptor radionuclide therapy of patients with neuroendocrine tumours.

Phys Med 2018 Dec 22;56:41-49. Epub 2018 Nov 22.

Department of Nuclear Medicine, Institut Jules Bordet-Université Libre de Bruxelles (ULB), 121 boulevard de Waterloo, 1000 Brussels, Belgium. Electronic address:

Purpose: Peptide receptor radionuclide therapy with Lu-DOTATATE has become a standard treatment modality in neuroendocrine tumours (NETs). No consensus has yet been reached however regarding the absorbed dose threshold for lesion response, the absorbed dose limit to organs-at-risk, and the optimal fractionation and activity to be administered. This is partly due to a lack of uniform and comparable dosimetry protocols. Read More

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http://dx.doi.org/10.1016/j.ejmp.2018.11.001DOI Listing
December 2018

A giant sacrococcygeal teratoma in adult female: A case report.

Int J Surg Case Rep 2019 22;54:47-50. Epub 2018 Nov 22.

Department of General Surgery, King Abdulla University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box (3030), Irbid, 22110, Jordan. Electronic address:

Introduction: Sacrococcygealteratoma is very rare in adults with only few cases reported in literature. It is a slow growing benign cystic tumor with 1-2% chance for malignant transformation and may attain a huge size causing pressure effect on pelvic and intra-abdominal organs. When grows caudally, it causes discomfort, skin excoriation and cosmetic disfigurement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183054
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http://dx.doi.org/10.1016/j.ijscr.2018.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280595PMC
November 2018
21 Reads

Heavy metals in organs of stray dogs and cats from the city of Naples and its surroundings (Southern Italy).

Environ Sci Pollut Res Int 2019 Feb 4;26(4):3473-3478. Epub 2018 Dec 4.

Istituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), Portici, 80055, Naples, Italy.

The aim of the present study was to assess the concentrations of lead (Pb) and cadmium (Cd) in the liver and kidney from stray dogs (Canis lupus familiaris) and cats (Felis catus) found dead between 2014 and 2017 in the city of Naples and its surrounding areas. These organs from 290 dogs and 88 cats were collected after ordinary necropsy of stray animals. Heavy metal concentrations were determined by using atomic absorption spectrophotometry (AAS). Read More

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http://link.springer.com/10.1007/s11356-018-3838-5
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http://dx.doi.org/10.1007/s11356-018-3838-5DOI Listing
February 2019
12 Reads

Impact of VMAT-IMRT compared to 3D conformal radiotherapy on anal sphincter dose distribution in neoadjuvant chemoradiation of rectal cancer.

Radiat Oncol 2018 Dec 3;13(1):237. Epub 2018 Dec 3.

Department of Radiation Oncology, Klinikum rechts der Isar, TU München, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Neoadjuvant radio- or chemoradiation (nIRT) therapy is the standard treatment for loco-regional advanced rectal cancer patients of the lower or middle third. Currently, intensity modulated radiation therapy (IMRT) is not the recommended radiation technique even though IMRT has advantages compared to 3D-radiation regarding dose sparing to organs at risk like small bowel and urinary bladder. So far, the benefit of IMRT concerning the anal sphincter complex is not examined. Read More

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http://dx.doi.org/10.1186/s13014-018-1187-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276230PMC
December 2018
3 Reads

Dosimetric comparison of bladder, rectal, and vaginal surface doses between ovoids and cylinder-based vaginal brachytherapy in carcinoma of the endometrium.

J Cancer Res Ther 2018 Oct-Dec;14(6):1191-1195

Division of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Purpose: The study aims to estimate the differences in vaginal surface, bladder, and rectal doses when adjuvant intracavitary brachytherapy is carried out with ovoids or with vaginal cylinders, in postoperative carcinoma endometrium and to assess the difference in variability in organs at risk (OAR) doses and thereby the reproducibility of application in subsequent sittings.

Materials And Methods: Fifteen patients each received vaginal brachytherapy with ovoid and cylindrical applicators. The dose received by 0. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_471_17DOI Listing
February 2019
14 Reads

Combined liver-kidney transplantation for primary hyperoxaluria type I in children: Single Center Experience.

Pediatr Transplant 2019 02 26;23(1):e13313. Epub 2018 Nov 26.

Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics, Cairo University, Cairo, Egypt.

Primary hyperoxalurias are rare inborn errors of metabolism with deficiency of hepatic enzymes that lead to excessive urinary oxalate excretion and overproduction of oxalate which is deposited in various organs. Hyperoxaluria results in serious morbid-ity, end stage kidney disease (ESKD), and mortality if left untreated. Combined liver kidney transplantation (CLKT) is recognized as a management of ESKD for children with hyperoxaluria type 1 (PH1). Read More

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http://dx.doi.org/10.1111/petr.13313DOI Listing
February 2019
4 Reads

Mesenchymal Neoplasms of the Genitourinary System: A Selected Review with Recent Advances in Clinical, Diagnostic, and Molecular Findings.

Surg Pathol Clin 2018 Dec;11(4):837-876

Departments of Pathology and Urology, VCU School of Medicine, 1200 East Marshall Street, PO Box 980662, Richmond, VA 23298, USA. Electronic address:

Mesenchymal neoplasms of the genitourinary (GU) tract often pose considerable diagnostic challenges due to their wide morphologic spectrum, relative rarity, and unexpected incidence at GU sites. Soft tissue tumors arise throughout the GU tract, whether from adventitia surrounding or connective tissues within the kidneys, urinary bladder, and male and female genital organs. This selected article focuses on a subset of these lesions, ranging from benign to malignant and encompassing a range of patterns of mesenchymal differentiation, where recent scholarship has lent greater insight into their clinical, molecular, or diagnostic features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18759181183004
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http://dx.doi.org/10.1016/j.path.2018.07.008DOI Listing
December 2018
9 Reads

Peripheral tissue oxygenation and the number of organs transplanted per donor.

Anaesth Intensive Care 2018 Nov;46(6):601-607

Critical Care Medicine, Akron Children's Hospital, Akron; Lifebanc; Cleveland, Ohio, USA.

Current donor management practices target macrohaemodynamic parameters, but it is unclear if this leads to improvements in microvascular perfusion and tissue oxygenation; the latter may have more impact on organ status. In a recent preclinical study we determined that brain death impaired tissue perfusion and oxygen utilisation in swine while pharmacologic correction of these deficits improved organ function and reduced markers of tissue injury. As a first step in translating the preclinical findings, we conducted a prospective observational study to determine if there was an association between peripheral tissue oxygenation (measured by near-infrared spectroscopy) in deceased by neurological criteria human donors and the number of organs transplanted. Read More

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http://dx.doi.org/10.1177/0310057X1804600611DOI Listing
November 2018
17 Reads

Diagnosis of urinary tract infection based on artificial intelligence methods.

Comput Methods Programs Biomed 2018 Nov 2;166:51-59. Epub 2018 Oct 2.

Department of Urology, Necmettin Erbakan University, Konya, Turkey.

Background And Objective: Urinary tract infection (UTI) is a common disease affecting the vast majority of people. UTI involves a simple infection caused by urinary tract inflammation as well as a complicated infection that may be caused by an inflammation of other urinary tract organs. Since all of these infections have similar symptoms, it is difficult to identify the cause of primary infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01692607183028
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http://dx.doi.org/10.1016/j.cmpb.2018.10.007DOI Listing
November 2018
22 Reads

Ureteral protection during microwave ablation of renal cell carcinoma: combined use of pyeloperfusion and hydrodissection.

Diagn Interv Radiol 2018 Nov;24(6):388-391

Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

A 56-year-old female with past medical history of thrombotic microangiopathy presented to her physician with nonspecific abdominal pain. A magnetic resonance imaging scan was obtained, which revealed a 3.1 cm mass arising from medial lower pole of the left kidney that was subsequently shown to be renal cell carcinoma by percutaneous biopsy. Read More

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http://dx.doi.org/10.5152/dir.2018.18137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223817PMC
November 2018
7 Reads

[Life-threatening hypercalcemia and acute kidney injury induced by etanercept].

Nephrol Ther 2018 Nov 29;14(6):478-482. Epub 2018 Jun 29.

Service de néphrologie, université catholique de Louvain, cliniques universitaires Saint-Luc, 10, avenue Hippocrate, 1200 Bruxelles, Belgique. Electronic address:

Drug-induced sarcoidosis-like disease is a rare, but not exceptional, side effect of anti-tumor necrosis factor (anti-TNF) agents. The organs most commonly involved are lungs, skin and lymph nodes. Kidney involvement is exceptional. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183013
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http://dx.doi.org/10.1016/j.nephro.2018.05.001DOI Listing
November 2018
10 Reads

Impact of the associated anorectal malformation on the outcome of spinal dysraphism after untethering surgery.

Pediatr Surg Int 2019 Feb 2;35(2):227-231. Epub 2018 Nov 2.

Department of Medical and Surgical Neonatology, Neonatal Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio, 4, 00165, Rome, Italy.

Purpose: To analyze the outcome after untethering surgery in patients with spinal dysraphism (SD), with or without associated anorectal malformation (ARM).

Methods: Patients operated on for SD, with (Group A) or without (Group B) associated ARM (1999-2015), were included. The post-operative outcome was analyzed in the two groups in terms of improving of clinical symptoms (neuro-motor deficits, bladder dysfunction, bowel dysfunction) and of instrumental examinations (urodynamics, bladder ultrasound, neurophysiology). Read More

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http://link.springer.com/10.1007/s00383-018-4400-8
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http://dx.doi.org/10.1007/s00383-018-4400-8DOI Listing
February 2019
10 Reads

Retroperitoneoscopic partial nephrectomy for renal cell carcinoma: A single-center Indian experience.

Urol Ann 2018 Oct-Dec;10(4):400-405

Department of Urology and Transplantation Surgery, Institute of Kidney Disease and Research Centre, Dr. H.L. Trivedi Institute of Transplant Sciences, Civil Hospital Campus, Ahmedabad, Gujarat, India.

Objective: Retroperitoneoscopy, by avoiding peritoneal breach and injury to intra-abdominal organs, provides a more direct and rapid access to the kidney and the renal hilum. Laparoscopic partial nephrectomy by retroperitoneal route (LPNR) is less commonly performed than transperitoneal route for early stage renal cancer. The objective of this study is to carry out the outcomes of partial nephrectomy using retroperitoneal approach. Read More

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http://www.urologyannals.com/text.asp?2018/10/4/400/243206
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http://dx.doi.org/10.4103/UA.UA_20_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194790PMC
November 2018
11 Reads

Retroperitoneal paraganglioma: a chameleon masquerading as an adrenal pheochromocytoma.

Ann R Coll Surg Engl 2019 Feb 29;101(2):e62-e65. Epub 2018 Oct 29.

Post Graduate Institute of Medical Education and Research, Advanced Urology Centre Nehru Hospital, Pgimer , Chandigarh , India.

Retroperitoneal paragangliomas are rare tumours arising from neural crest cells located near or in the autonomic nervous system; right from the skull bass to the pelvic floor. Often called the great masqueraders, their diagnosis and treatment is often difficult and fraught with danger, considering the close proximity of these tumours to important retroperitoneal organs. A 29-year-old woman presented to the outpatient department with complaints of paroxysms of headache, sweating and palpitations for one year. Read More

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https://publishing.rcseng.ac.uk/doi/10.1308/rcsann.2018.0193
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http://dx.doi.org/10.1308/rcsann.2018.0193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351861PMC
February 2019
13 Reads

PE17 protein from Mycobacterium tuberculosis enhances Mycobacterium smegmatis survival in macrophages and pathogenicity in mice.

Microb Pathog 2019 Jan 23;126:63-73. Epub 2018 Oct 23.

State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China. Electronic address:

The capacity of Mycobacterium tuberculosis to survive and cause disease is strongly correlated with its ability to escape multiple defense strategies in hosts. In particular, M. tuberculosis has the remarkable capacity to survive within the hostile environment of macrophages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010183128
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http://dx.doi.org/10.1016/j.micpath.2018.10.030DOI Listing
January 2019
6 Reads

Gastrointestinal and Urinary Tract Endometriosis: A Review on the Commonest Locations of Extrapelvic Endometriosis.

Adv Med 2018 26;2018:3461209. Epub 2018 Sep 26.

Department of Obstetrics and Gynecology, University Hospital of Larissa, Thessaly, Larissa, Greece.

Extrapelvic endometriosis is a rare entity that presents serious challenges to researchers and clinicians. Endometriotic lesions have been reported in every part of the female human body and in some instances in males. Organs that are close to the uterus are more often affected than distant locations. Read More

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https://www.hindawi.com/journals/amed/2018/3461209/
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http://dx.doi.org/10.1155/2018/3461209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180923PMC
September 2018
4 Reads

Pancake kidney, a rare and often misdiagnosed malformation: a case report and radiological differential diagnosis.

J Ultrasound 2018 Oct 25. Epub 2018 Oct 25.

Department of Diagnostic and Interventional Radiology and Neuroradiology of IRCCS, San Matteo University Hospital Foundation, Pavia, Italy.

Renal ectopia and fusion anomalies are Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) that are usually incidentally detected and asymptomatic. Patients affected present a higher risk of complications like recurrent urinary tract infections or obstruction. Pancake kidney (PK) is one of the rarest types of renal anomaly with complete fusion of the superior, mild and inferior poles of both kidneys in the pelvic cavity. Read More

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http://link.springer.com/10.1007/s40477-018-0331-4
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http://dx.doi.org/10.1007/s40477-018-0331-4DOI Listing
October 2018
12 Reads

Development of urinary organs in domestic cat during the embryonic and fetal periods.

Microsc Res Tech 2018 Nov 20;81(11):1286-1294. Epub 2018 Oct 20.

Sector of Wild and Domestic Animals Anatomy, College of Veterinary Medicine and Animal Science of the University of Sao Paulo FMVZ/USP, São Paulo, Brazil.

The embryonic origin of the urogenital system came from the intermediate mesoderm. Kidney development involves three successive renal systems with a fast chronological overlap: the pronephro, the mesonephro, and the metanephro. Due to the lack of specific knowledge about this system in cats the present work aimed to describe their urinary organs development, focusing on the structures seen in pronephro, mesonephro, and metanephro during the embryonic and fetal stages of development. Read More

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http://doi.wiley.com/10.1002/jemt.23135
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http://dx.doi.org/10.1002/jemt.23135DOI Listing
November 2018
13 Reads

Dosimetric analysis of stereotactic rotational versus static intensity-modulated radiation therapy for pancreatic cancer.

Cancer Radiother 2018 Dec 12;22(8):754-762. Epub 2018 Oct 12.

Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, 05505 Songpa-gu, Seoul, Republic of Korea.

Purpose: Stereotactic body radiation therapy is a promising treatment modality for locally advanced pancreatic cancer. To determine the optimal radiation treatment, we compared the plan characteristics of volumetric-modulated arc therapy and intensity-modulated radiation therapy when administered with stereotactic body radiation therapy to treat pancreatic cancer.

Patients And Methods: Fifteen patients with locally advanced pancreatic cancer were treated by stereotactic body radiation therapy at a dose of 24-32Gy in four fractions with marker-guided gated volumetric-modulated arc therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12783218183034
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http://dx.doi.org/10.1016/j.canrad.2018.01.007DOI Listing
December 2018
13 Reads

Intersex, Hermaphroditism, and Gonadal Plasticity in Vertebrates: Evolution of the Müllerian Duct and Amh/Amhr2 Signaling.

Annu Rev Anim Biosci 2018 Oct 10. Epub 2018 Oct 10.

Physiological Chemistry, Biocenter, University of Würzburg, D-97074 Würzburg, Germany; email:

In vertebrates, sex organs are generally specialized to perform a male or female reproductive role. Acquisition of the Müllerian duct, which gives rise to the oviduct, together with emergence of the Amh/Amhr2 system favored evolution of viviparity in jawed vertebrates. Species with high sexspecific reproductive adaptations have less potential to sex reverse, making intersex a nonfunctional condition. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-animal-020
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http://dx.doi.org/10.1146/annurev-animal-020518-114955DOI Listing
October 2018
1 Read

Indocyanine green angiography for preserving the ureteral branch of the uterine artery during radical hysterectomy: Two case report.

Medicine (Baltimore) 2018 Oct;97(40):e12692

Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guang Xi Medical University, Nanning, People's Republic of China.

Rationale: Conventional radical hysterectomy is frequently associated with postoperative ureteral ischemic necrosis, urinary fistula, stenosis, and kidney seeper. Some have suggested that preserving the ureteral branch during radical hysterectomy may reduce the incidence of ureteral complications. However, the feasibility of such preservation has not been explored using intraoperative imaging techniques. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0007
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http://dx.doi.org/10.1097/MD.0000000000012692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200471PMC
October 2018
4 Reads

New and Emerging Applications of Magnetic Resonance Elastography of Other Abdominal Organs.

Top Magn Reson Imaging 2018 Oct;27(5):335-352

Department of Radiology, Mayo Clinic, Rochester, MN.

Increasing clinical experience and ongoing research in the field of magnetic resonance elastography (MRE) is leading to exploration of its applications in other abdominal organs. In this review, the current research progress of MRE in prostate, uterus, pancreas, spleen, and kidney will be discussed. The article will describe patient preparation, modified technical approach including development of passive drivers, modification of sequences, and inversion. Read More

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http://dx.doi.org/10.1097/RMR.0000000000000182DOI Listing
October 2018
9 Reads

Evaluation of offline adaptive planning techniques in image-guided brachytherapy of cervical cancer.

J Appl Clin Med Phys 2018 Nov 3;19(6):316-322. Epub 2018 Oct 3.

Department of Radiation Oncology, Cone Health Cancer Center, Greensboro, NC, USA.

Modern three-dimensional image-guided intracavitary high dose rate (HDR) brachytherapy is often used in combination with external beam radiotherapy (EBRT) to manage cervical cancer. Intrafraction motion of critical organs relative to the HDR applicator in the time between the planning CT and treatment delivery can cause marked deviations between the planned and delivered doses. This study examines offline adaptive planning techniques that may reduce intrafraction uncertainties by shortening the time between the planning CT and treatment delivery. Read More

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http://dx.doi.org/10.1002/acm2.12462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236843PMC
November 2018
1 Read

A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease.

PLoS One 2018 1;13(10):e0204239. Epub 2018 Oct 1.

Department of Renal Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom.

Background: Patients with chronic kidney disease (CKD) have increased risk of development of end-stage renal disease (ESRD) and early mortality. Fibrosis is the central pathogenic process in CKD and is caused by dysregulated extracellular matrix (ECM) remodeling. The laminin γ1 chain (LAMC1) is a core structural protein present in the basement membrane of several organs, including the kidneys. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166934PMC
March 2019
18 Reads

Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats.

Food Chem Toxicol 2018 Dec 25;122:80-86. Epub 2018 Sep 25.

Division of Pathology, National Institute of Health Sciences, Japan.

5-Hexenyl isothiocyanate (5-HeITC) is a naturally derived flavoring substance from Wasabia japonica. To clarify the toxicological profile of 5-HeITC, we performed a subchronic toxicity study of 5-HeITC with intragastric administration at daily doses of 0, 3, 12, or 48 mg/kg body weight (BW) to 6-week-old male and female F344/DuCrj rats for 13 weeks. Body weight gain was decreased in the male 48 mg/kg BW group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183070
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http://dx.doi.org/10.1016/j.fct.2018.09.060DOI Listing
December 2018
2 Reads

Oxidative stress and the altered reaction to it in Fabry disease: A possible target for cardiovascular-renal remodeling?

PLoS One 2018 27;13(9):e0204618. Epub 2018 Sep 27.

Department of Medicine, Nephrology, University of Padua, Padua Italy.

Background: Fabry disease is characterized by deficient expression/activity of α-GalA with consequent lysosomal accumulation in various organs of its substrate Gb3. Despite enzyme replacement therapy, Fabry disease progresses with serious myocardial, cerebral and renal manifestations. Gb3 accumulation may induce oxidative stress (OxSt), production of inflammatory cytokines and reduction of nitric oxide, which may impact on Fabry disease's clinical manifestations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204618PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160124PMC
March 2019
11 Reads