368,999 results match your criteria Female Reproductive Organs


Cretaceous lophocoronids with short proboscis and retractable female genitalia provide the earliest evidence for their feeding and oviposition habits.

Cladistics 2022 Jun 27. Epub 2022 Jun 27.

College of Life Sciences and Academy for Multidisciplinary Studies, Capital Normal University, 105 Xisanhuanbeilu, Haidian District, Beijing, 100048, China.

We describe two new species of Lophocoronidae: Acanthocorona hedida Zhang, Shih and Engel sp. n. and Acanthocorona venulosa Zhang, Shih and Engel sp. Read More

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Common Multiple Primary Cancers Associated With Breast and Gynecologic Cancers and Their Risk Factors, Pathogenesis, Treatment and Prognosis: A Review.

Front Oncol 2022 8;12:840431. Epub 2022 Jun 8.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

The mammary gland is closely related to the female reproductive system in many aspects, affecting the whole gynecological system. Breast cancer (BC) is the most common malignancy in women and associated with considerable negative effects. Due to various factors including co-pathogenic genetic mutations, environment factors, lifestyle, behavioral factors, treatment regimens and in-creased survival of patients with BC, there is an increased probability of developing additional primary gynecologic cancers such as ovarian cancer (OC), endometrial cancer (EC), and cervical cancer (CC). Read More

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Pathogenesis of Brucella ovis in pregnant mice and protection induced by the candidate vaccine strain B. Ovis ΔabcBA.

Vaccine 2022 Jun 21. Epub 2022 Jun 21.

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

Ovine brucellosis caused by Brucella ovis is a major cause of reproductive failure in sheep. This study aimed to evaluate transplacental infection and pathogenicity of B.ovis wild type strain ATCC 25,840 (WT B. Read More

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The Penis, the Vagina and HIV Risk: Key Differences (Aside from the Obvious).

Viruses 2022 May 27;14(6). Epub 2022 May 27.

Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.

Globally, most Human Immunodeficiency Virus type 1 (HIV) transmission occurs through vaginal-penile sex (heterosexual transmission). The local immune environment at the site of HIV exposure is an important determinant of whether exposure during sex will lead to productive infection, and the vaginal and penile immune milieus are each critically shaped by the local microbiome. However, there are key differences in the microbial drivers of inflammation and immune quiescence at these tissue sites. Read More

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Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage-Preliminary Study.

Nutrients 2022 Jun 7;14(12). Epub 2022 Jun 7.

Department of Clinical Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland.

(1) Background: The aim of this study was to assess the concentrations of selected elements in female patients with cancer of the reproductive organs, taking into account the stage of treatment. (2) Methods: The study sample consisted of 51 patients with advanced endometrial cancer and ovarian cancer, undergoing chemotherapy. The median age of the studied patients with endometrial cancer was 66. Read More

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The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues.

Molecules 2022 Jun 8;27(12). Epub 2022 Jun 8.

Joint Laboratory of the Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun 130118, China.

Previous studies have shown that circular RNAs are directly or indirectly involved in the occurrence of various diseases by regulating gene expression. However, the acting mechanism of circular RNAs in endometritis remains unclear. In this study, we successfully established an endometritis model in mouse using ; endometrial integrity was destroyed, inflammatory cells infiltrated and the expression of IL-6, IL-1β, TNF-α was significantly up-regulated. Read More

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Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures.

Medicina (Kaunas) 2022 Jun 8;58(6). Epub 2022 Jun 8.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milano, Italy.

To avoid complications related to mid-urethral slings (MUS), alternative procedures to treat stress urinary incontinence (SUI), such as urethral bulking agents (UBAs) have been adopted. The aim of this review is to narratively report the efficacy and safety of UBAs for SUI treatment. For this review, research from PubMed and EMBASE was performed to evaluate relevant studies that were undertaken from January 2012 to January 2022. Read More

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New Innovations for the Treatment of Vulvovaginal Atrophy: An Up-to-Date Review.

Medicina (Kaunas) 2022 Jun 6;58(6). Epub 2022 Jun 6.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy.

Vulvovaginal atrophy (VVA) is a chronic progressive disease involving the female genital apparatus and lower urinary tract. This condition is related to hypoestrogenism consequent to menopause onset but is also due to the hormonal decrease after adjuvant therapy for patients affected by breast cancer. Considering the high prevalence of VVA and the expected growth of this condition due to the increase in the average age of the female population, it is easy to understand its significant social impact. Read More

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Effects of Melatonin on the Transcriptome of Human Granulosa Cells, Fertilization and Blastocyst Formation.

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Yamaguchi University, Minamikogushi 1-1-1, Ube 755-8505, Japan.

Melatonin is a promising reagent that can improve assisted reproductive technology (ART) outcomes in infertility patients. However, melatonin is not effective for all infertile patients, and it remains unclear for which patients melatonin would be effective. This study examined the effects of melatonin on ART outcomes and examined its mechanisms. Read More

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Effect of Passage Number of Conditioned Medium Collected from Equine Amniotic Fluid Mesenchymal Stem Cells: Porcine Oocyte Maturation and Embryo Development.

Int J Mol Sci 2022 Jun 12;23(12). Epub 2022 Jun 12.

Division of Animal and Dairy Science, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Korea.

Oocyte in vitro maturation (IVM) is the most important first step in in vitro embryo production. One prerequisite for the success of IVM in oocytes is to provide a rich culture microenvironment that meets the nutritional needs of developing oocytes. We applied different equine amniotic fluid mesenchymal stem cell conditioned medium (eAFMSC-CM) from passages 7, 18, and 27 to porcine oocytes during IVM to determine its effects on oocyte development and subsequent embryo development, specifically. Read More

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Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries.

Int J Mol Sci 2022 Jun 7;23(12). Epub 2022 Jun 7.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The increased concern regarding the reduction in female fertility and the impressive numbers of women undergoing fertility treatment support the existence of environmental factors beyond inappropriate programming of developing ovaries. Among these factors are pyrethroids, which are currently some of the most commonly used pesticides worldwide. The present study was performed to investigate the developmental effects of the pyrethroid-based insecticide allethrin on ovarian function in rat offspring in adulthood. Read More

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Prevalence of Pathogenic Germline Variants and Their Association with Clinical Characteristics in Patients with Epithelial Ovarian Cancer in a Rural Area of Japan.

Genes (Basel) 2022 Jun 18;13(6). Epub 2022 Jun 18.

Department of Obstetrics and Gynecology, Tokushima University, Tokushima 770-8503, Japan.

The prevalence of germline or pathogenic variants (g-PV) in patients with primary epithelial ovarian cancer (OC) in a rural area of Japan and their association with clinical characteristics, including treatment response and survival outcome, were investigated. A total of 123 unbiased patients with OC were tested for g and g using next-generation sequencing-based targeted amplicon sequencing. Clinical characteristics of OC patients with and without g status were compared. Read More

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Upregulation of miR-33 Exacerbates Heat-Stress-Induced Apoptosis in Granulosa Cell and Follicular Atresia of Nile Tilapia () by Targeting TGFβ1I1.

Genes (Basel) 2022 Jun 2;13(6). Epub 2022 Jun 2.

Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Ministry of Agriculture, Wuxi 214081, China.

High temperature affects egg quality and increases follicular atresia in teleosts. The present study aimed to explore the regulated mechanism of ovary syndrome of Nile tilapia () exposed to heat stress. To this end, we conducted histological and biochemical analyses and integrated miRNA-target gene analyses. Read More

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Retrogene Duplication and Expression Patterns Shaped by the Evolution of Sex Chromosomes in Malaria Mosquitoes.

Genes (Basel) 2022 May 28;13(6). Epub 2022 May 28.

Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Genes that originate during evolution are an important source of novel biological functions. Retrogenes are functional copies of genes produced by retroduplication and as such are located in different genomic positions. To investigate retroposition patterns and retrogene expression, we computationally identified interchromosomal retroduplication events in nine portions of the phylogenetic history of malaria mosquitoes, making use of species that do or do not have classical sex chromosomes to test the roles of sex-linkage. Read More

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Role of Mitochondria Transfer in Infertility: A Commentary.

Cells 2022 Jun 8;11(12). Epub 2022 Jun 8.

IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain.

Mitochondria transfer techniques were first designed to prevent the transmission of diseases due to mutations in mtDNA, as these organelles are exclusively transmitted to the offspring by the oocyte. Despite this, given the crucial role of mitochondria in oocyte maturation, fertilization and subsequent embryo development, these approaches have been proposed as new potential strategies to overcome poor oocyte quality in infertile patients. This condition is a very common cause of infertility in patients of advanced maternal age, and patients with previous in vitro fertilization (IVF) attempt failures of oocyte origin. Read More

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Fetal and Newborn Management of Cloacal Malformations.

Children (Basel) 2022 Jun 14;9(6). Epub 2022 Jun 14.

Division of Colorectal and Pelvic Reconstruction, Children's National Hospital, Washington, DC 20010, USA.

Cloaca is a rare, complex malformation encompassing the genitourinary and anorectal tract of the female in which these tracts fail to separate in utero, resulting in a single perineal orifice. Prenatal sonography detects a few cases with findings such as renal and urinary tract malformations, intraluminal calcifications, dilated bowel, ambiguous genitalia, a cystic pelvic mass, or identification of other associated anomalies prompting further imaging. Multi-disciplinary collaboration between neonatology, pediatric surgery, urology, and gynecology is paramount to achieving safe outcomes. Read More

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Integrated multi-omics analyses reveals molecules governing sperm metabolism potentially influence bull fertility.

Sci Rep 2022 Jun 23;12(1):10692. Epub 2022 Jun 23.

Animal Genomics Laboratory, ICAR - National Dairy Research Institute, Karnal, Haryana, 132 001, India.

Bull fertility is of paramount importance in bovine industry because semen from a single bull is used to breed several thousands of cows; however, so far, no reliable test is available for bull fertility prediction. In the present study, spermatozoa from high- and low-fertility bulls were subjected to high-throughput transcriptomic, proteomic and metabolomic analysis. Using an integrated multi-omics approach the molecular differences between high- and low-fertility bulls were identified. Read More

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hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.

Nat Commun 2022 Jun 23;13(1):3588. Epub 2022 Jun 23.

Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell development. However, the underlying molecular mechanism that controls alternative mRNA expression during germ cell development remains elusive. Herein, we show that hnRNPH1 is highly expressed in the reproductive system and recruits the PTBP2 and SRSF3 to modulate the alternative splicing in germ cells. Read More

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New Complex of Cryptic Species Discovered in Genus Biblis (Papilionoidea: Nymphalidae: Biblidinae) in Mexico.

Neotrop Entomol 2022 Jun 23. Epub 2022 Jun 23.

Depto de Conservación de La Biodiversidad, El Colegio de La Frontera Sur (ECOSUR), Chetumal, Mexico.

Our research focuses on demonstrating the existence of cryptic species named under Biblis aganisa Boisduval. We used COI sequences to delimit Biblis species for Mexico using species delimitation analyses and examined phylogenetic relationships with sequences from Mexico, Costa Rica, Argentina, USA, and Guana Island using a Bayesian inference tree. We performed a discriminant analysis with quantitative traits using female and male wing and genitalia, and a tree of maximum parsimony based on 39 qualitative characters of wings, head, and male genitalia. Read More

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Human Trial for the Effect of Plasma-Activated Water Spray on Vaginal Cleaning in Patients with Bacterial Vaginosis.

Med Sci (Basel) 2022 Jun 18;10(2). Epub 2022 Jun 18.

Department of Pharmacology, College of Medicine, Hanyang University, Seoul 04736, Korea.

Underwater plasma discharge temporally produces several reactive radicals and/or free chlorine molecules in water, which is responsible for antimicrobial activity. Hence, it can simply sanitize tap water without disinfectant treatment. Additionally, the spraying technique using cleaning water exploits deep application in the narrow and curved vaginal tract of patients. Read More

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How Customers Evaluate Genitalia versus Torso Sex Toys on Amazon.com: A Content Analysis of Product Reviews.

Eur J Investig Health Psychol Educ 2022 Jun 1;12(6):563-578. Epub 2022 Jun 1.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Sex toys are widely marketed on the Internet. Browsing for, buying, and reviewing sex toys online are popular cybersexual activities. The aim of this study was to investigate consumers' experiences with different types of realistic sex toys via online product reviews on Amazon. Read More

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COMPARISON OF TVUS, MRI, AND FROZEN SECTION METHODS IN PREOPERATIVE DETECTION OF MYOMETRIAL INVASION IN PATIENTS WITH ENDOMETRIAL CANCER.

Acta Clin Croat 2021 Dec;60(4):675-682

1Inonu University Medicine Faculty, Obstetrics and Gynecology Department, Malatya, Turkey; 2Inonu University Medicine Faculty, Pathology Department, Malatya, Turkey; 3Inonu University Medicine Faculty, Radiology Department, Malatya, Turkey.

We aimed to evaluate the depth of myometrial invasion preoperatively with transvaginal ultrasound, magnetic resonance imaging, and frozen section examination techniques in patients diagnosed with endometrial cancer. Our study included 65 patients. Transvaginal ultrasound and magnetic resonance imaging were performed in study patients in the preoperative period. Read More

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December 2021

Characterization of the Interrenal Gland and Sexual Traits Development in -Deficient Zebrafish.

Front Endocrinol (Lausanne) 2022 6;13:910639. Epub 2022 Jun 6.

State key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.

Unlike the Cytochrome P450, family 17, subfamily A, member 1 (Cyp17a1), which possesses both 17α-hydroxylase and 17,20-lyase activities involved in the steroidogenic pathway that produces androgens and estrogens, Cytochrome P450, family 17, subfamily A, polypeptide 2 (Cyp17a2) possesses only 17α-hydroxylase activity and is known essential for the synthesis of cortisol. Besides with expressed in testes and ovaries, where the is mainly expressed, is also expressed in the interrenal gland in fish. Until now, the roles of in fish, especially in sexual traits development and hypothalamic-pituitary-interrenal (HPI) axis, are poorly studied. Read More

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Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis.

Ann Med 2022 Dec;54(1):1444-1451

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: To clarify clinical importance of serum CA19-9, CA-125, and plasma D-dimer (D-D) levels in detecting spontaneously ruptured ovarian endometriosis (OE).

Materials And Methods: We retrospectively examined 173 patients with endometriosis out of 735 cases of OE between 2013 and 2019. Among these, 21 cases were diagnosed as "spontaneously ruptured" after surgery, while the remaining cases were unruptured. Read More

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December 2022

Estimating female malaria mosquito age by quantifying Y-linked genes in stored male spermatozoa.

Sci Rep 2022 Jun 22;12(1):10570. Epub 2022 Jun 22.

Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

Vector control strategies are among the most effective measures to combat mosquito-borne diseases, such as malaria. These strategies work by altering the mosquito age structure through increased mortality of the older female mosquitoes that transmit pathogens. However, methods to monitor changes to mosquito age structure are currently inadequate for programmatic implementation. Read More

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[Villi exosomes deliver HLA-G to enhance the expression of osteoglycin and pleiotrophin in decidual NK cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):535-541

Reproductive Medicine Center, Department of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China. *Corresponding author, E-mail:

Objective To identify the effect of HLA-G-containing exosomes on the secretory function of growth-promoting factors osteoglycin (OGN) and pleiotrophin (PTN) by decidual NK (dNK) cells. Methods dNK cells were co-cultured with HLA-G-containing exosomes from the villi of patients undergoing unexplained recurrent pregnancy loss (uRPL) and normal induced abortion, respectively. Sequentially, OGN and PTN of the dNK cells were determined using real time quantitative PCR and western blotting. Read More

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DeepCyto: a hybrid framework for cervical cancer classification by using deep feature fusion of cytology images.

Math Biosci Eng 2022 Apr;19(7):6415-6434

Department of Computer Engineering, Pimpri Chinchwad College of Engineering, Pune, Maharashtra, India.

Cervical cancer is the second most commonly seen cancer in women. It affects the cervix portion of the vagina. The most preferred diagnostic test required for screening cervical cancer is the pap smear test. Read More

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A Critical Assessment of the Requirement for a Single Time Point Vaginal Cytology on the Day of Necropsy in Rats.

Toxicol Pathol 2022 Jun 22:1926233221103273. Epub 2022 Jun 22.

Charles River Laboratories, 's-Hertogenbosch, The Netherlands.

For toxicology testing of (agro)chemicals, different study types are being performed with general and/or reproductive toxicity endpoints (see Organisation for Economic Co-operation and Development guidelines). In most of these rat studies, vaginal cytology is performed on serial samples (collected by lavage) for evaluation of cycle regularity and evidence of mating, and/or on a single sample collected on the day of necropsy for information on the estrous cycle stage and allowing correlation with histopathology. In the latter case, the utility of vaginal cytology can be argued. Read More

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Female Genital Mutilation: Treatment Updates and the Need for Education.

J Craniofac Surg 2022 May 12;33(3):734-737. Epub 2021 Oct 12.

Division of Plastic Surgery, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine.

Introduction: Female genital mutilation/cutting (FGM/C) refers to ritual surgical procedures performed that intentionally alter genitalia for nonmedical purposes. Female genital mutilation/ cutting is a lifelong problem for women that can have detrimental effects on menstruation, pregnancy, sexual health, and self-esteem. In 2016 the Centers for Disease Control and Prevention estimated 513,000 women and children in the United States were victims of or at risk for FGM/C. Read More

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Tackling cellular senescence by targeting miRNAs.

Biogerontology 2022 Jun 21. Epub 2022 Jun 21.

Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, 200011, China.

Cellular senescence, which is characterized by permanent proliferation arrest, has become an important target for the amelioration of various human diseases. The activity of senescent cells is mainly related to the senescence-associated secretory phenotype (SASP). The SASP can cause chronic inflammation in local tissues and organs through autocrine and paracrine mechanisms, and a series of factors secreted by senescent cells can deteriorate the cellular microenvironment, promoting tumor formation and exacerbating aging-related diseases. Read More

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