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J Med Case Rep 2021 May 27;15(1):273. Epub 2021 May 27.

Orange Regional Medical Center, Middletown, NY, USA.

Background: Felty syndrome is a rare manifestation of chronic rheumatoid arthritis in which patients develop extraarticular features of hepatosplenomegaly and neutropenia. The typical presentation of Felty syndrome is in Caucasians, females, and patients with long-standing rheumatoid arthritis of 10 or more years. This case report presents a patient with an early-onset and atypical demographic for Felty syndrome. Read More

Plant Dis 2021 May 10. Epub 2021 May 10.

Centro de Investigación en Alimentación y Desarrollo, Coordinación Culiacán, Carretera El Dorado Km 5.5, Campo el Diez, Culiacán, Sinaloa, Mexico, 80110;

Guava ( L.) is a small tree belonging to the Myrtaceae family and it is distributed worldwide in the tropical and subtropical areas. During the summer of 2019, symptoms of fruit anthracnose were observed on approx. Read More

J Clin Apher 2021 May 4. Epub 2021 May 4.

Department of Pathology, Division of Transfusion Medicine and Hemostasis, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Hyperviscosity syndrome (HVS) is a life-threatening syndrome caused by high concentrations of large plasma proteins like IgM, rheumatoid factor, and other immune complexes, leading to increased blood viscosity and symptoms such as visual abnormalities, neurological impairment, bleeding diathesis, and thrombosis. While Waldenström's macroglobulinemia accounts for 80% to 90% of cases, HVS may develop in other clinical settings characterized by elevations in plasma proteins. Limited evidence currently exists describing the safety and efficacy of therapeutic plasma exchange (TPE) for the management of HVS secondary to non-neoplastic conditions. Read More

Laryngoscope 2021 Mar 30. Epub 2021 Mar 30.

Department Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.

Delayed tracheal rupture following total thyroidectomy (TT) is rare and represents a potential airway emergency. A 34-year-old female with Felty Syndrome underwent TT for Hashimoto's thyroiditis. On post-operative day 10, she presented with subcutaneous emphysema and an anterolateral tracheal perforation on CT scan. Read More

Intern Med J 2021 02;51(2):303-304

Department of Immunology, Nepean Hospital, Sydney, New South Wales, Australia.

Breast J 2021 Mar 3;27(3):209-215. Epub 2021 Jan 3.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, and Geisel School of Medicine, Hanover, NH, USA.

To investigate clinical and pathologic features of encapsulated papillary carcinomas (EPCs) that may be associated with invasive disease and characterize the axillary staging practices for EPCs at our institution. A pathology database search for cases containing "papillary carcinoma" was performed. Slides were reviewed by two pathologists. Read More

Medicine (Baltimore) 2020 Dec;99(51):e23608

Department of traditional Chinese medicine, southern theater general hospital, the Chinese People's Liberation Army, Guangzhou, China.

Rationale: Felty syndrome is a rare and life-threatening type of rheumatoid arthritis (RA).

Patient Concerns: A patient with RA had skin rash and subcutaneous hemorrhage, with a significant decrease in blood hemoglobin (Hb), white blood cell count (WBC), and blood platelet count (BPC).

Diagnoses: The patient had a history of RA, splenomegaly, decreased Hb, WBC, BPC, and normal immunological indexes, combined with a series of bone marrow related tests and genetic tests. Read More

Plant Dis 2020 Dec 1. Epub 2020 Dec 1.

Chinese Academy of Agricultural Sciences, 12661, Institute of Special Wild Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China;

Bunge (Fabaceae) is a perennial medicinal herb widely cultivated in China. In June 2018, root rot was observed on two-year-old plants in Chaoyangshan town (northeastern China). In a 40-ha field, over 40% of the plants exhibited root rot and the infected area ranged from 10 to 70% of the roots. Read More

Mycobiology 2020 Sep 8;48(5):341-350. Epub 2020 Sep 8.

College of Agriculture and Life Sciences, Kyungpook National University, Daegu, Korea.

Three fungal strains belonging to the class Sordariomycetes were isolated from soils collected from Gyeongsangbuk-do in Korea. They were identified as (UD CT 1-3-3 and KNU-19GWF1) and sp. nov. Read More

Plant Dis 2020 Jul 28. Epub 2020 Jul 28.

College of Coastal Agricultural Sciences, Biotechnology, Zhanjiang, Guangdong, China;

Ctenanthe oppenheimiana (E. Morren) K. Schum. Read More

Biomed Res Int 2020 1;2020:2618260. Epub 2020 Jul 1.

Center of Liver Diseases, Beijing Ditan Hospital of Capital Medical University, Beijing, China.

Felty's syndrome (FS) is a disorder wherein patients with rheumatoid arthritis develop splenomegaly, neutropenia, and in some cases, portal hypertension without underlying cirrhosis. Esophageal variceal bleeding is a complication of FS in patients with portal hypertension. In contrast to splenectomy, few reports exist on the management of variceal bleeding with endoscopic therapy. Read More

J Cancer Res Clin Oncol 2020 Nov 23;146(11):2777-2815. Epub 2020 Jul 23.

Department of Environmental Health Sciences, Florida International University, Miami, USA.

Purpose: Nuclear respiratory factor 1 (NRF1) drives estrogen-dependent breast tumorigenesis. Herein we examined the impact of NRF1 activity on the aggressiveness and disparate molecular signature of breast cancer in Black, White, Asian, and Hispanic women.

Methods: NRF1 activity by transcription factor target enrichment analysis and causal NRF1-target gene signatures by Bayesian Network Inference with Java Objects (BANJO) and Markov Chain Monte Carlo (MCMC)-based gene order were examined in The Cancer Genome Atlas (TCGA) breast cancer cohorts. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620941303

Nassau University Medical Center, East Meadow, NY, USA.

Large granular lymphocyte leukemia (LGL) is a clonal, lymphoproliferative disorder with an indolent disease course. T-cell LGL (T-LGL) is the most common type of LGL driven from T-cell lineage (85%). The coexistence of T-LGL with several types of autoimmune disorders, mostly rheumatoid arthritis (RA), has been reported. Read More

Mol Neurobiol 2020 Sep 27;57(9):3827-3845. Epub 2020 Jun 27.

Department of Environmental Health Sciences, Florida International University, Miami, FL, 33199, USA.

Despite tremendous progress in understanding the pathobiology of astrocytoma, major gaps remain in our knowledge of the molecular basis underlying the aggressiveness of high-grade astrocytoma (glioblastoma - GBM). Recently, we and others have shown nuclear respiratory factor 1 (NRF1) transcription factor being highly active in human cancers, but its role in astrocytoma remains unknown. Therefore, the purpose of this study was to uncover the role of NRF1 in the progression of GBM. Read More

Open Access Rheumatol 2020 28;12:65-71. Epub 2020 May 28.

Internal Medicine Department, Imam Khomeini Hospital, Ardabil University of Medical Sciences (ARUMS), Ardabil, Iran.

Background And Aims: Familial Mediterranean fever (FMF) is a prototype of autoinflammatory disease and mainly associated with gene mutations. This single-center study as an experience represents FMF-coexisting disease in the FMF registration database.

Methods: Four hundred patients who had FMF based on clinical criteria (Tel-Hashomer) and/or mutations enrolled the study. Read More

J Clin Rheumatol 2020 Jun 10. Epub 2020 Jun 10.

Department of Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH.

Nat Prod Res 2020 Jun 5:1-5. Epub 2020 Jun 5.

Department of Chemistry, Yasooj Branch, Islamic Azad University, Yasooj, Iran.

has been used to treat gastrointestinal disorders, inflammation, diabetes and rheumatism. This plant has beneficial therapeutic properties. In this research the changes in the composition of essential oils from the aerial parts of were determined at different temperatures and times. Read More

Rheumatol Int 2020 Jul 28;40(7):1143-1149. Epub 2020 Apr 28.

Department of Rheumatology and Immunology, Jingzhou Central Hospital, Jingzhou Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Jingzhou, 434000, China.

Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side effects. Here we report a clinical FS case that was treated with Tocilizumab (TCZ) successfully. Read More

Insects 2020 Apr 9;11(4). Epub 2020 Apr 9.

Division of Plant Industry, Florida Department of Agriculture and Consumer Services, Gainesville, FL 32614, USA.

The lychee erinose mite (LEM), (Keifer) is a serious pest of lychee ( Sonn.). LEM causes a type of gall called 'erineum' (abnormal felty growth of trichomes from the epidermis), where it feeds, reproduces and protects itself from biotic and abiotic adversities. Read More

BMC Pediatr 2020 04 7;20(1):153. Epub 2020 Apr 7.

Department of Rheumatology, Children's Hospital of Fudan University, 399 Wan-yuan Road, Shanghai, 201102, China.

Background: Felty's syndrome (FS) is characterized by the triad of rheumatoid arthritis (RA), splenomegaly and neutropenia. The arthritis is typically severe and virtually always associated with high-titer rheumatoid factor. The presence of persistent neutropenia is generally required to make the diagnosis. Read More

Methods Mol Biol 2020 ;2102:35-59

Department of Environmental Health Sciences, Florida International University, Miami, FL, USA.

The objective of this chapter is to describe step-by-step bioinformatics and functional genomics solutions for analyzing ChIP-Seq and RNA-Seq data for understanding the regulatory mechanisms of chromatin modifiers and transcription factors that can drive pathogenesis of chronic complex human diseases, such as cancer. Here we have used two transcription regulatory proteins: nuclear respiratory factor 1 (NRF1) and inhibitor of differentiation protein 3 (ID3) for ChIP-Seq and RNA-Seq data as examples for discussing the importance of selecting the appropriate computational analysis methods, software, and parameters for the processing of raw data as well as their integrative regulatory landscape analysis to obtain accurate and reliable results. Both ChIP-Seq and RNA-Seq analytic methodologies are used as instructional examples to identify NRF1 or ID3 binding to the promoters and enhancers in the genome and their effects on the activity as well as to discover target genes that can drive breast cancer. Read More

BMC Neurosci 2020 01 22;21(1). Epub 2020 Jan 22.

Department of Emergency Medicine, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, USA.

Background: Opioids are the most effective drugs commonly prescribed to treat pain. Due to their addictive nature, opioid pain relievers are now second to marijuana, ahead of cocaine with respect to dependence. Ours and other studies suggest potential toxic effects of chronic opioid administration leading to neuronal degeneration. Read More

Diagn Cytopathol 2020 Apr 24;48(4):390-395. Epub 2019 Dec 24.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Malignant melanoma with myxoid features (MMM) is a rare melanoma variant in which tumor cells are embedded within a basophilic myxoid stroma. The stromal matrix is composed of acidic mucopolysaccharides, which are thought to be produced by mesenchymal stromal cells in response to melanoma invasion. Interestingly, this myxoid matrix is more often seen in metastasis from a primary tumor that does not have a myxoid stroma. Read More

J Cutan Pathol 2020 Mar 23;47(3):219-225. Epub 2019 Nov 23.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Spontaneous regression of basal cell carcinomas (BCC) is a well-documented phenomenon. In practice, we have observed melanocytic aggregates associated with BCC at various stages of regression showing unique morphologic features.

Methods: Fourteen cases featuring melanocytic aggregates were retrospectively identified through a pathology database search. Read More

Rheumatology (Oxford) 2020 01;59(1):256-259

Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School Hospital, Kochi University, Nankoku, Japan.

J Autism Dev Disord 2019 Oct;49(10):4363-4364

Division of Developmental-Behavioral Pediatrics, Medical University of South Carolina, 135 Rutledge Avenue, MSC 561, Charleston, SC, 29425, USA.

Piece it Together (PIT) is a comprehensive wellness program designed for transitional age youth with Autism Spectrum Disorder and mild neurodevelopmental disabilities that focuses on exercise, nutrition, socialization, and stress-reduction. The PIT Summer Program is a 6-week program, consisting of 90-min classes, twice a week. Each class incorporates 45-min of exercise and health and wellness lessons in goal setting, nutrition, bones and muscle anatomy, and stress management. Read More

Med Clin (Barc) 2020 05 4;154(10):420-421. Epub 2019 Jun 4.

Servicio de Medicina Interna, Consorci Hospitalari de Vic, Vic, Barcelona, España.

Mayo Clin Proc 2019 06;94(6):1073-1078

Advisor to residents and Consultant in Hematology, Mayo Clinic, Rochester, MN. Electronic address:

Melanoma Res 2019 12;29(6):603-611

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center.

We have previously reported increased glucose transporter 1 (GLUT1) expression in melanoma compared to benign nevi, associated with a significantly lower survival rate. GLUT1 upregulation was highly specific for distinguishing melanoma from benign nevi, yet poorly sensitive, likely because of expression of other GLUT isoforms. The purpose of this study was to evaluate GLUT2 and GLUT3, as melanoma biomarkers. Read More