751 results match your criteria Felty Syndrome


Rheumatoid Arthritis: A Brief Overview of the Treatment.

Med Princ Pract 2018 2;27(6):501-507. Epub 2018 Sep 2.

Larkin Community Hospital, Miami, Florida, USA.

Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease, affecting the joints with varying severity among patients. The risk factors include age, gender, genetics, and environmental exposure (cigarette smoking, air pollutants, and occupational). Many complications can follow, such as permanent joint damage requiring arthroplasty, rheumatoid vasculitis, and Felty syndrome requiring splenectomy if it remains unaddressed. Read More

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http://dx.doi.org/10.1159/000493390DOI Listing
September 2018
3 Reads

Large granular lymphocytic leukemia CD3CD56: a challenge for the biologist and the physician.

Ann Biol Clin (Paris) 2018 Aug;76(4):429-434

Laboratoire de biologie clinique, CHU de Charleroi, Lodelinsart, Belgique.

Large granular lymphocyte leukemia (LGL) are chronic lymphoproliferative disorders classified into three main groups: T-cell LGL leukemia (T-LGL), aggressive NK-cell leukemia and chronic lymphoproliferative disorder of NK cells (NK-LGL). Patients with LGL leukemia exhibit chronic (>3 months) and moderate (<1G/L) to substantial monoclonal expansion of large granular lymphocytes in the peripheral blood. Cytologically, large granular lymphocytes are medium to large cells which are further characterized by an eccentric nucleus and a slightly basophilic cytoplasm containing azurophilic granules. Read More

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http://dx.doi.org/10.1684/abc.2018.1367DOI Listing
August 2018
10 Reads

Inflammatory arthritis and crystal arthropathy: Current concepts of skin and systemic manifestations.

Clin Dermatol 2018 Jul - Aug;36(4):533-550. Epub 2018 Apr 10.

Division of Dermatology, The University of Arizona College of Medicine, Tucson, Arizona, USA. Electronic address:

Systemic inflammatory disorders frequently involve the skin, and when cutaneous disease develops, such dermatologic manifestations may represent the initial sign of disease and may also provide valuable prognostic information about the underlying disorder. Familiarity with the various skin manifestations of systemic disease is therefore paramount and increases the likelihood of accurate diagnosis, which may facilitate the implementation of an appropriate treatment strategy. An improvement in quality of life and a reduction in the degree of morbidity may also be a realized benefit of accurate recognition of these skin signs. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.04.010DOI Listing
December 2018
3 Reads

Neutropaenia and splenomegaly without arthritis: think rheumatoid arthritis.

BMJ Case Rep 2018 Jul 11;2018. Epub 2018 Jul 11.

Department of Rheumatology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

Felty syndrome(FS) is an uncommon, but severe, extra-articular manifestation of rheumatoid arthritis (RA). It occurs in patients with longstanding RA. It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly. Read More

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http://dx.doi.org/10.1136/bcr-2018-225359DOI Listing
July 2018
3 Reads

Panzytopenie und Splenomegalie.

Praxis (Bern 1994) 2018 Apr;107(8):463-466

1 Spitalzentrum Oberwallis, Spital Visp.

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https://econtent.hogrefe.com/doi/10.1024/1661-8157/a002947
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http://dx.doi.org/10.1024/1661-8157/a002947DOI Listing
April 2018
14 Reads

Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids.

Clin Case Rep 2018 03 31;6(3):509-512. Epub 2018 Jan 31.

2nd Academic Department of Internal Medicine National and Kapodistrian University of Athens School of Medicine Hippokration General Hospital Athens Greece.

In severe cases of pancytopenia with subsequent infections due to long-term untreated Felty's syndrome, the initiation of immunosuppressive treatment with sole prednisone (1 mg/kg ) should be considered, despite that, the low neutrocytes count would make one physician hesitant. A full resolution of whole blood count within 3 weeks and a 30% reduction in spleens sized was noted. Read More

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http://dx.doi.org/10.1002/ccr3.1396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838277PMC
March 2018
16 Reads

Skin manifestations of rheumatoid arthritis.

G Ital Dermatol Venereol 2018 Apr 24;153(2):243-255. Epub 2018 Jan 24.

Unit of Dermatopathology, San Gallicano Dermatological Institute, Rome, Italy -

Rheumatoid arthritis is a chronic systemic disease that, in addition to articular involvement, may exhibit a variety of extraarticular manifestations. The skin is frequently involved mainly in the most severe forms of the disease. Rheumatoid nodules, accelerated rheumatoid nodulosis, rheumatoid nodulosis, Felty syndrome, rheumatoid vasculitis, pyoderma gangrenosum, rheumatoid neutrophilic dermatosis, interstitial granulomatous dermatitis, and palisaded neutrophilic granulomatous dermatitis are reviewed both clinically and histologically. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.05872-8DOI Listing
April 2018
48 Reads

Chronic neutropenia in LGL leukemia and rheumatoid arthritis.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):181-186

University of Virginia, Charlottesville, VA.

This section reviews the diagnostic criteria and pathogenesis of large granular lymphocyte (LGL) leukemia. There is a particular focus on the overlap of LGL leukemia and rheumatoid arthritis (Felty's syndrome). Current understanding of the mechanisms of neutropenia in these disorders is discussed. Read More

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http://dx.doi.org/10.1182/asheducation-2017.1.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142558PMC
December 2017
35 Reads

Somatic mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia.

Haematologica 2018 02 7;103(2):304-312. Epub 2017 Dec 7.

Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Finland

Felty syndrome is a rare disease defined by neutropenia, splenomegaly, and rheumatoid arthritis. Sometimes the differential diagnosis between Felty syndrome and large granular lymphocyte leukemia is problematic. Recently, somatic and mutations were discovered in 30-40% of patients with large granular lymphocyte leukemia. Read More

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2017.175729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792275PMC
February 2018
26 Reads

Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease.

Biomed Res Int 2017 13;2017:6307109. Epub 2017 Jul 13.

Department of Environmental & Occupational Health, Florida International University, Miami, FL, USA.

The overwhelming increase in the global incidence of obesity and its associated complications such as insulin resistance, atherosclerosis, pulmonary disease, and degenerative disorders including dementia constitutes a serious public health problem. The Inhibitor of DNA Binding/Differentiation-3 (ID3), a member of the ID family of transcriptional regulators, has been shown to play a role in adipogenesis and therefore ID3 may influence obesity and metabolic health in response to environmental factors. This review will highlight the current understanding of how ID3 may contribute to complex chronic diseases via metabolic perturbations. Read More

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http://dx.doi.org/10.1155/2017/6307109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530454PMC
April 2018
7 Reads

Successful treatment of refractory neutropenia in Felty's syndrome with rituximab.

Scand J Rheumatol 2018 07 28;47(4):340-341. Epub 2017 Jul 28.

c Department of Radiology , National Cheng Kung University Hospital , Tainan , Taiwan.

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http://dx.doi.org/10.1080/03009742.2017.1334816DOI Listing
July 2018
3 Reads

Felty's Syndrome: A Qualitative Case Study.

Medsurg Nurs 2017 03;26(2):105-9, 118

Felty's syndrome is a triad of rheumatoid arthritis, splenomegaly, and neutropenia. This rare disorder is difficult to diagnose and produces many complications. The purpose of this descriptive qualitative case study was to provide a comprehensive, context-bound understanding of one patient's struggle with the condition. Read More

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March 2017
15 Reads

"Rituximab: A Safe Treatment in a Patient With Refractory Felty Syndrome and Recurrent Infections".

J Clin Rheumatol 2017 Jan;23(1):70-71

Department/Institution, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University hospital Dubrava, University of Zagreb School of Medicine, Avenija Gojka Šuška 6, Zagreb, Croatia.

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http://dx.doi.org/10.1097/RHU.0000000000000440DOI Listing
January 2017
10 Reads

Primary cardiac B cell lymphoma: Manifestation of Felty's syndrome or TNFα antagonist.

Pathol Res Pract 2016 Dec 17;212(12):1191-1193. Epub 2016 Oct 17.

Department of Pathology, Amiens University Hospital, France.

Primary cardiac B cell lymphoma is rare. To date, fewer than 90 cases have been described in the literature. We report a 67-year-old woman with a 30-year history of rheumatoid arthritis, who had received treatment with leflunomide for 10 years and infliximab for 2 years. Read More

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http://dx.doi.org/10.1016/j.prp.2016.10.004DOI Listing
December 2016
12 Reads

Non-articular Felty's syndrome: An uncommon diagnosis.

Neth J Med 2015 Nov;73(9):435-6

Department of Internal Medicine, Henry Ford Health System, Detroit, MI.

Felty's syndrome is a triad of rheumatoid arthritis, neutropenia, and splenomegaly. We hereby report an unusual case of non-articular Felty's syndrome and its management along with discussing the importance of appropriately ruling out alternate causes of neutropenia with splenomegaly. Read More

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November 2015
7 Reads

Severe extra-articular manifestations of rheumatoid arthritis in absence of concomitant joint involvement following long-term spontaneous remission. A case report.

Reumatol Clin 2016 Jul-Aug;12(4):223-5. Epub 2015 Aug 24.

Servicio de Clínica Médica, Hospital Provincial del Centenario , Rosario, Santa Fe, Argentina.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease occasionally associated with severe extra-articular manifestations, mostly in cases of longstanding highly active disease. We report the case of a 56 year-old woman diagnosed with active RA at the age of 40. After 5 years of high activity, her arthritis subsides spontaneously during pregnancy despite the lack of treatment with disease-modifying anti-rheumatic drugs. Read More

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http://dx.doi.org/10.1016/j.reuma.2015.07.006DOI Listing
April 2017
12 Reads

Management of neutropenia in patients with rheumatoid arthritis.

Joint Bone Spine 2015 Jul 26;82(4):235-9. Epub 2015 Mar 26.

Service de médecine interne, hôpital du Haut-Lévêque, université de Bordeaux, 33604 Pessac, France; Département de rhumatologie, hôpital Lapeyronie, université de Montpellier 1, 34295 Montpellier cedex 5, France.

Neutropenia is defined as a neutrophil count lower than 1.5g/L, with categorization as mild, moderate, or severe when the count is 1.5-1g/L, 1-0. Read More

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http://dx.doi.org/10.1016/j.jbspin.2015.01.005DOI Listing
July 2015
20 Reads

A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma.

Acta Derm Venereol 2015 Jul;95(6):754-5

Department of Dermatology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan.

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http://dx.doi.org/10.2340/00015555-2067DOI Listing
July 2015
7 Reads

Treatment of pseudo Felty's syndrome: Is there a place for rituximab?

Joint Bone Spine 2015 May 23;82(3):196-9. Epub 2015 Jan 23.

Department of rheumatology, CHRU de Besançon, 2, Boulevard Fleming, 25030 Besançon, France. Electronic address:

Objective: Pseudo Felty's syndrome (PFS) is an uncommon syndrome occurring in Rheumatoid Arthritis and characterized by a monoclonal expansion of lymphocytes with neutropenia. Methotrexate is the first line recommended treatment. In case of incomplete response, cyclophosphamide may be used for hematological features but does not share the same efficacy on arthritis. Read More

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http://dx.doi.org/10.1016/j.jbspin.2014.12.001DOI Listing
May 2015
9 Reads

A case of rheumatoid arthritis with Felty syndrome complicated by late-onset ankylosing spondylitis and psoriatic arthritis: a potpourri of rheumatic diseases.

J Clin Rheumatol 2015 Jan;21(1):53-5

Division of Rheumatology Department of Medicine Stony Brook University Medical Center Stony Brook, NY Long Island Regional Arthritis & Osteoporosis Care PC, Babylon Department of Medicine Mt Sinai School of Medicine, New York Department of Radiology Prohealth Care Associates Lake Success, NY.

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http://dx.doi.org/10.1097/RHU.0000000000000205DOI Listing
January 2015
6 Reads

Spleen and liver enlargement in a patient with rheumatoid arthritis.

Reumatol Clin 2015 Jul-Aug;11(4):227-31. Epub 2014 Nov 11.

Sección de Reumatología, Hospital J. M. Cullen, Santa Fe, Argentina.

We describe the case of a 51-year-old woman with a seropositive, erosive, and non-nodular rheumatoid arthritis of 15 year of evolution. The patient had poor compliance with medical visits and treatment. She came to the clinic with persistent pancytopenia and spleen and liver enlargement. Read More

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http://dx.doi.org/10.1016/j.reuma.2014.09.006DOI Listing
January 2017
5 Reads

Successful treatment of a large cutaneous ulcer and improvement in the hematologic manifestations of felty syndrome with rituximab.

J Clin Rheumatol 2014 Dec;20(8):440-1

From the *Commonwealth Medical College, Scranton; and †Arthritis Center, Department of Rheumatology, Susquehanna Health Medical Group, Williamsport, PA.

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http://pdfs.journals.lww.com/jclinrheum/2014/12000/Successfu
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http://dx.doi.org/10.1097/01.RHU.0000450285.43361.abDOI Listing
December 2014
6 Reads

Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature.

Blood Coagul Fibrinolysis 2015 Mar;26(2):211-3

aDepartment of Internal Medicine bDivision of Hematology and Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Large granular lymphocyte (LGL) leukemia is an indolent lymphoproliferative malignancy which dysregulates humoral immunity and underlies the myriad autoimmune phenomena. We describe a 62-year-old woman with Felty's syndrome who developed a severe bleeding diathesis. Laboratory evaluation demonstrated acquired inhibitors to both factor VIII (FVIII) and fibrinogen, likely secondary to T-cell LGL leukemia. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000209DOI Listing
March 2015
14 Reads

A beneficial long-term and consistent response to rituximab in the treatment of refractory neutropenia and arthritis in a patient with Felty syndrome.

J Clin Rheumatol 2014 Oct;20(7):398

Department of Physical Medicine and Rehabilitation Ankara University Medical School Altındağ, Ankara Turkey 06230 Department of Physical Medicine and Rehabilitation Ankara University Medical School Ankara, Turkey.

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http://dx.doi.org/10.1097/RHU.0000000000000175DOI Listing
October 2014
9 Reads

Presentation of three cases followed up with a diagnosis of Felty syndrome.

Eur J Rheumatol 2014 Sep 1;1(3):120-122. Epub 2014 Sep 1.

Department of Internal Medicine, Sakarya Training and Research Hospital, Sakarya, Turkey.

An effective treatment strategy for Felty syndrome (FS) has not been developed so far. In this article, three cases with FS, who responded to different treatment modalities, have been presented. Case 1 was a 52-year-old male patient who initially received methotrexate, and then, he was switched to granulocyte colony-stimulating factor (G-CSF) and cyclosporine treatment when his neutropenia was further deteriorated. Read More

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http://dx.doi.org/10.5152/eurjrheumatol.2014.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042221PMC
September 2014
23 Reads

Syndromes affecting skin and mucosa.

Atlas Oral Maxillofac Surg Clin North Am 2014 Sep;22(2):135-51

Division of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, 515 Delaware Street SE #16-116B, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cxom.2014.06.001DOI Listing
September 2014
5 Reads

[Rituximab for treatment of Felty’s syndrome].

Z Rheumatol 2014 Jun;73(5):465-6, 468

Felty’s syndrome is a rare variant of severe seropositive rheumatoid arthritis with neutropenia and splenomegaly. It is difficult to treat and associated with a poor prognosis due to the substantial risk of infections. This article presents the case of a patient with refractory disease who responded to rituximab with permanent normalization of neutrophil counts. Read More

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http://dx.doi.org/10.1007/s00393-014-1380-5DOI Listing
June 2014
8 Reads

Felty's syndrome with hyperthyroidism: a case report and literature review.

Int J Rheum Dis 2014 Jan 2;17(1):122-4. Epub 2013 Jul 2.

Department of Rheumatology, Second Affiliated Hospital, Nanchang, China.

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http://dx.doi.org/10.1111/1756-185X.12117DOI Listing
January 2014
6 Reads

Citrullination of autoantigens implicates NETosis in the induction of autoimmunity.

Ann Rheum Dis 2014 Mar 29;73(3):483-91. Epub 2013 Nov 29.

Program in Cellular and Molecular Medicine, Boston Children's Hospital and Harvard Medical School, , Boston, Massachusetts, USA.

Tolerance blocks the expression of autoantibodies, whereas autoimmunity promotes it. How tolerance breaks and autoantibody production begins thus are crucial questions for understanding and treatment of autoimmune diseases. Evidence implicates cell death and autoantigen modifications in the initiation of autoimmune reactions. Read More

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http://dx.doi.org/10.1136/annrheumdis-2013-203844DOI Listing
March 2014
28 Reads

Felty's syndrome and hypofibrinogenemia: an unusual target for anti-cyclic citrullinated peptide antibodies?

Mod Rheumatol 2015 Sep 29;25(5):790-3. Epub 2015 Jul 29.

a Division of Immunology and Allergology, University Hospitals of Geneva , Switzerland.

Background: Rheumatoid arthritis (RA) is a risk factor for the development of Felty's syndrome and large granular lymphocyte (LGL) leukemia. Anti-cyclic citrullinated peptide (CCP) antibodies are considered highly specific for RA and are directed against various citrullinated antigens, including citrullinated fibrinogen. Anti-CCP antibodies may interfere with the detection of citrullinated proteins and their function. Read More

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http://dx.doi.org/10.3109/14397595.2013.844392DOI Listing
September 2015
11 Reads

[Large granular lymphocyte leukemia: clinical and pathogenic aspects].

Rev Med Interne 2013 Sep 5;34(9):553-60. Epub 2013 Aug 5.

Service de médecine interne, hôpital du Haut Lévêque, avenue Magellan, 33604 Pessac, France.

Large granular lymphocyte leukemia (LGL) is a hematologic disorder characterized by a monoclonal expansion of large lymphocytes containing azurophilic granules with a T CD3(+)CD57(+) or Natural Killer (NK) CD3(-)CD56(+) phenotype. The World Health Organization (WHO) classification identifies three entities: the T LGL, the chronic lymphoproliferative disorder of NK-cells, and the aggressive NK-cell leukemia. T LGL and chronic lymphoproliferative disorder of NK-cells are indolent diseases frequently associated with cytopenias and a wide spectrum of auto-immune manifestations. Read More

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http://dx.doi.org/10.1016/j.revmed.2012.12.020DOI Listing
September 2013
6 Reads

Two suspected cases of immunoglobulin-mediated interference causing falsely low vancomycin concentrations with the Beckman PETINIA method.

Ann Pharmacother 2013 Apr 19;47(4):e19. Epub 2013 Mar 19.

Pharmacy Services, University of Alberta Hospital, Edmonton, Alberta, Canada.

Objective: To describe 2 recent cases of suspected immunoglobulin-mediated interference with the Beckman Coulter particle-enhanced turbidimetric inhibition immunoassay (PETINIA) used to measure vancomycin serum or plasma concentrations and to review the existing literature.

Case Summary: A 64-year-old woman with a history of multiple immune-related comorbidities received vancomycin for treatment of a prosthetic joint infection growing coagulase-negative Staphylococcus spp. A 33-year-old man with a history of Felty syndrome received vancomycin for the treatment of methicillin-resistant Staphylococcus aureus pneumonia. Read More

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http://dx.doi.org/10.1345/aph.1R566DOI Listing
April 2013
12 Reads

[The spleen in non-malignant haematological disorders].

Ther Umsch 2013 Mar;70(3):157-62

Abteilung Hämatologie und Hämatologisches Zentrallabor, Luzerner Kantonsspital, Luzern.

The spleen functions as a filter of the circulating blood, removing aging or abnormal red blood cells, intraerythrocyte inclusions as well as foreign particals. As the spleen is composed of lymphocytic tissue, circulatory elements and mononuclear phagocytic cells it plays an important role in the nonspecific as well as the specific immune response. Additionally, the spleen serves as a reservoir for circulating blood cells, especially platelet sequestration by the spleen is well do cumented. Read More

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http://dx.doi.org/10.1024/0040-5930/a000384DOI Listing
March 2013
4 Reads

Felty's syndrome without rheumatoid arthritis?

Clin Rheumatol 2013 May 5;32(5):701-4. Epub 2013 Jan 5.

B. Shine Department of Rheumatology, Rambam Health Care Campus and Technion, POB 9602, Haifa 31096, Israel.

Felty's syndrome (FS) is characterized by neutropenia and splenomegaly in patients with seropositive (RF+, anti-CCP+) rheumatoid arthritis (RA). As a result of neutropenia, affected persons are increasingly susceptible to infections. In the majority of patients, FS appears in the course of long-standing and well-established RA. Read More

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http://dx.doi.org/10.1007/s10067-012-2157-3DOI Listing
May 2013
8 Reads

Complement system in SLE as a target for antibodies.

Curr Rheumatol Rev 2013 ;9(1):34-44

III Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacky University of Olomouc, I.P. Pavlova 6, 772 00 Olomouc, Czech Republic.

SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstances, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a component of the complement system is anti-C1q. Read More

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January 2015
10 Reads

Female with rash, acute kidney failure and rheumatoid arthritis.

J Postgrad Med 2012 Jul-Sep;58(3):217-20

Department of Nephrology, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.

This case describes a 42-year-old female with longstanding history of rheumatoid arthritis (RA) and Felty syndrome (FS). She presented with acute renal kidney failure, skin rash and hemoptysis. A clinical suspicion of small vessel vasculitis (SVV) was thought, serology was also positive for various markers of SVV. Read More

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http://dx.doi.org/10.4103/0022-3859.101642DOI Listing
January 2013
5 Reads

Autoimmune manifestations in large granular lymphocyte leukemia.

Clin Lymphoma Myeloma Leuk 2012 Dec 19;12(6):400-5. Epub 2012 Sep 19.

Department of Medicine, University of Connecticut Medical Center, Farmington, CT 06030-1235, USA.

Large granular lymphocyte (LGL) leukemia features a group of indolent lymphoproliferative diseases that display a strong association with various autoimmune conditions. Notwithstanding, these autoimmune conditions have not been comprehensively characterized or systematized to date. As a result, their clinical implications remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.clml.2012.06.006DOI Listing
December 2012
5 Reads
2 Citations

Histoplasmosis mimicking felty syndrome.

J Clin Rheumatol 2012 Aug;18(5):278

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http://dx.doi.org/10.1097/RHU.0b013e3182642477DOI Listing
August 2012
4 Reads

Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome.

Pol Arch Med Wewn 2012 ;122(7-8):374-9

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.

Felty's syndrome (FS) is a severe arthritic disorder that features chronic neutrophil activation and progresses to neutropenia and susceptibility to unabated infections. The life‑threatening manifestations of FS have focused the attention of clinical experimenters who have made persistent efforts to find new and effective therapies. This review highlights important milestones in the research on FS and draws attention to recent studies on the antigen specificity of antibodies present in patients' sera. Read More

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December 2012
5 Reads

Fatal Staphylococcus aureus bacteremia in the Felty syndrome: a maltreatment-suspected case.

Leg Med (Tokyo) 2012 Sep 4;14(5):246-8. Epub 2012 May 4.

Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa, Japan.

Familial neglect was suspected when an older deceased female was found to have large decubitus ulcers and weight loss. Postmortem examinations including histopathology and bacterial culture revealed systemic Staphylococcus aureus infection as the cause of death. The victim might have exhibited Felty syndrome, which is characterized by complications of splenomegaly and neutropenia in the underlying rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.legalmed.2012.03.006DOI Listing
September 2012
6 Reads

One case of Felty's syndrome efficiently treated with rituximab.

Joint Bone Spine 2012 Dec 7;79(6):624-5. Epub 2012 Mar 7.

Hôpital Lariboisière, Rheumatology Department, pôle appareil locomoteur, centre Viggo-Petersen, 2 rue Ambroise-Paré, Paris, France.

Felty's syndrome (FS) is a rare association of rheumatoid arthritis (RA), neutropenia and splenomegaly. Mechanisms of neutropenia in FS are unclear but involve both innate and humoral immunity, impaired granulopoiesis and decreased granulocyte half-life. Several treatments have been used without clear efficiency. Read More

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http://dx.doi.org/10.1016/j.jbspin.2012.01.013DOI Listing
December 2012
12 Reads

Mast cell activation syndrome masquerading as agranulocytosis.

Authors:
Lawrence B Afrin

Mil Med 2012 Jan;177(1):113-7

Section of Hematology/Oncology, Medical Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.

Acquired agranulocytosis is a rare, life-threatening disorder. The few known causes/associations usually are readily identifiable (e.g. Read More

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January 2012
17 Reads

Temporal bone histopathology and immunoglobulin deposition in Sjogren's syndrome.

Otol Neurotol 2012 Feb;33(2):258-66

University of California-Los Angeles, Division of Head and Neck Surgery, California 90095, USA.

Hypothesis: The histopathology of Sjogren's syndrome (SS) in the human inner ear correlates with mouse models of autoimmune inner ear disease.

Background: SS is an autoimmune disease in which 25% of patients have sensorineural hearing loss (SNHL). The inner ear histology in a SS mouse model has shown degeneration of the stria vascularis (SV) and immunoglobulin G deposition on the basement membrane of SV blood vessels. Read More

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http://dx.doi.org/10.1097/MAO.0b013e318241b548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262845PMC
February 2012
32 Reads

Biological agents in the management of Felty's syndrome: a systematic review.

Semin Arthritis Rheum 2012 Apr 25;41(5):658-68. Epub 2011 Nov 25.

Department of Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, Barcelona, Spain.

Objective: To review and summarize the information available on the effectiveness and safety of biological therapies in refractory Felty's syndrome (FS).

Methods: We describe a case of FS with severe neutropenia and recurrent bacterial infections unresponsive to disease-modifying antirheumatic drug treatment and long-term administration with granulocyte colony-stimulating factor, in which treatment with rituximab (RTX) was useful and resulted in a sustained neutrophil response. Current evidence on the use of biological therapies in FS is also analyzed through a systematic review of the English-language literature, based on a PubMed search. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2011.08.008DOI Listing
April 2012
18 Reads

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps.

Arthritis Rheum 2012 Apr 27;64(4):982-92. Epub 2011 Oct 27.

University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Objective: To test the hypothesis that autoantigen modifications by peptidylarginine deiminase type 4 (PAD-4) increase immunoreactivity.

Methods: We assembled sera from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Felty's syndrome (FS), and antineutrophil cytoplasmic antibody-associated vasculitides (AAVs), as well as sera from control subjects without autoimmune diseases. The sera were tested for binding to activated neutrophils, deiminated histones, and neutrophil extracellular chromatin traps (NETs). Read More

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http://dx.doi.org/10.1002/art.33432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729190PMC
April 2012
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The spectrum of large granular lymphocyte leukemia and Felty's syndrome.

Curr Opin Hematol 2011 Jul;18(4):254-9

Department of Medicine, Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-0850, USA.

Purpose Of Review: Patients with chronic large granular lymphocyte (LGL) leukemia often have rheumatoid arthritis (RA), neutropenia and splenomegaly, thereby resembling the manifestations observed in patients with Felty's syndrome, which is a rare complication of RA characterized by neutropenia and splenomegaly. Both entities have similar clinical and laboratory presentation, as well as a common genetic determinant, HLA-DR4, indicating they may be part of the same disease spectrum. This review paper seeks to discuss the underlying pathogenesis and therapeutic algorithm of RA, neutropenia and splenomegaly in the spectrum of LGL leukemia and Felty's syndrome. Read More

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http://dx.doi.org/10.1097/MOH.0b013e32834760fbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377227PMC
July 2011
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Management of autoimmune neutropenia in Felty's syndrome and systemic lupus erythematosus.

Autoimmun Rev 2011 May 18;10(7):432-7. Epub 2011 Jan 18.

Department of Internal Medicine, Jamaica Hospital Medical Center, NY 11418, United States.

Autoimmune neutropenia, caused by neutrophil-specific autoantibodies is a common phenomenon in autoimmune disorders such as Felty's syndrome and systemic lupus erythematosus. Felty's syndrome is associated with neutropenia and splenomegaly in seropositive rheumatoid arthritis which can be severe and with recurrent bacterial infections. Neutropenia is also common in systemic lupus erythematosus and it is included in the current systemic lupus classification criteria. Read More

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http://dx.doi.org/10.1016/j.autrev.2011.01.006DOI Listing
May 2011
5 Reads

Demographic, clinical, and serological features of Turkish patients with rheumatoid arthritis: evaluation of 165 patients.

Authors:
Senol Kobak

Clin Rheumatol 2011 Jun 19;30(6):843-7. Epub 2011 Jan 19.

Department of Rheumatology, Manisa Hospital, Manisa Devlet Hastanesi, Manisa, Turkey.

The study was designed to describe demographic, clinical, serological, and radiological characteristics of patients with rheumatoid arthritis (RA) followed-up by a single institution. One hundred sixty-five patients, diagnosed as RA using ACR classification criteria, and followed-up in the rheumatology clinic between December 2005 and January 2010, were enrolled in the study. Of the patients, 125 were female, and 40 were male. Read More

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http://dx.doi.org/10.1007/s10067-011-1678-5DOI Listing
June 2011
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Felty's syndrome and Kala-azar: a challenge for the rheumatologist.

Rev Bras Reumatol 2010 Nov-Dec;50(6):710-3

Hospital Santa Casa de Belo Horizonte, Minas Gerais, Brazil.

Case report of a patient with rheumatoid arthritis who developed severe neutropenia, splenomegaly and was diagnosed with Felty's syndrome. The patient later developed Kala-azar. Both diseases have similar clinical and laboratory presentation, making the differential diagnosis difficult. Read More

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June 2011
11 Reads