4,823 results match your criteria Febrile Seizures


Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system.

J Neuroendocrinol 2019 Feb 18:e12697. Epub 2019 Feb 18.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

Stress is among the most frequently self-reported factors provoking epileptic seizures in children and adults. It is still unclear though, why some people display stress-sensitive seizures while others don't. Recently, we showed that young epilepsy patients with stress-sensitive seizures exhibit a dysregulated hypothalamus-pituitary-adrenal (HPA)-axis. Read More

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http://dx.doi.org/10.1111/jne.12697DOI Listing
February 2019

Iron supplementation should be given in breath-holding spells regardless of anemia

Turk J Med Sci 2019 Feb 11;49(1):230-237. Epub 2019 Feb 11.

Background/aim: The purpose of this retrospective study was to determine the effectiveness of oral iron therapy in breath-holding spells and evaluation of electrocardiographical changes

Materials And Methods: Three hundred twelve children aged 1–48 months and diagnosed with breath-holding spells between January 2017 and April 2018 were included. Patients’ laboratory findings were compared with 100 patients who had one simple febrile seizure.

Results: Cyanotic breath-holding spells were diagnosed in 85. Read More

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http://dx.doi.org/10.3906/sag-1805-92DOI Listing
February 2019
1 Read

Melioidosis with a subdural collection - a case report.

BMC Infect Dis 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Medicine, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.

Background: Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions and abscesses, and can present with varied clinical manifestations. Melioidosis involving the central nervous system is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3782-0DOI Listing
February 2019

Clinical spectrum of -related epileptic disorders.

Neurology 2019 Feb 8. Epub 2019 Feb 8.

From the University of Tübingen (S. Wolking, J.M., Y.G.W., H.L., J.S.), Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Luxembourg Centre for Systems Biomedicine (P.M.), University of Luxembourg, Esch-sur-Alzette; Pediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G., C.M.), Children's Hospital Anna Meyer, University of Florence, Italy; Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Services (R.S.M.), University of Southern Denmark, Odense; Department of Clinical and Experimental Epilepsy (S.B.), UCL Institute of Neurology and Epilepsy Society, UK, London; Division of Neurology (K.L.H., I.H.), Children's Hospital of Philadelphia, PA; Department of Pediatric Neurology (C.D.A.), Centre de Compétences Maladies Rares, CHU Besançon; Service de Génétique (N.C.), Hospices Civils des Lyon, Bron; GENDEV Team (N.C.), Neurosciences Research Center of Lyon, Bron, France; Neuropediatric Clinic and Clinic for Neurorehabilitation (K.S.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Beaumont Hospital (P.W.-W.), Dublin, Ireland; Department of Pediatrics, Division of Medical Genetics, Institute of Human Genetics (B.A.M.), Departments of Neurology and Pediatrics (A.N.), and Departments of Neurology and Pediatrics, and Institute of Human Genetics (M.R.C.), University of California, San Francisco; Department of Neurology (W.V.P.), University Hospitals Leuven, Belgium; Department of Pediatrics (L.L.S.), Hvidovre Hospital, Denmark; King's College Hospital (S.O., E.H., S.G., D.K.P.), London; Evelina London Children's Hospital (S.O., E.H., S.G.), London, UK; Section of Genetics (K.B., M.S.S.), Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora; Clinique Bernoise Montana (T.D.), Crans-Montana, Switzerland; Department of Neuropediatrics (H.M.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics (A.T.P., S.J.L.K., J.C.T.) and Department of Oncology (D.V.V.), University of Oxford, UK; Epilepsy Center (M.P.C.), Health Sciences Department, San Paolo Hospital, University of Milan; Child Neuropsychiatry (F.D.), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Italy; Departments of Neurology and Clinical Genomics (R.H.G.) and Health Sciences Research and Clinical Genomics (E.W.K., C.K.), Mayo Clinic, Rochester, MN; Ambry Genetics (Z.P.), Aliso Viejo, CA; Department of Clinical Neuroscience (S.T.), King's College London; New Medicines (M.A., D.M.), UCB Pharma, Slough, UK; Neuropediatric Clinic and Clinic for Neurorehabilitation (G.J.K.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Research Institute for Rehabilitation, Transition and Palliation (G.J.K.), PMU Salzburg, Austria; Department of Neurology (D.H.L.), University of California, San Francisco; Neurogenetics Group (S. Weckhuysen), Center for Molecular Neurology, VIB, Antwerp; Laboratory of Neurogenetics (S. Weckhuysen), Institute Born-Bunge, University of Antwerp; Department of Neurology (S. Weckhuysen), Antwerp University Hospital, Antwerp, Belgium; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (D.K.P.), MRC Centre for Neurodevelopmental Disorders (D.K.P.), King's College London, UK; Evelina London Children's Hospital (D.K.P.), London, UK; Department of Neuropediatrics (I.H.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; Institute of Neuroscience (R.H.T.), Henry Wellcome Building, Newcastle University; Neurology Research Group (M.I.R.), Institute of Life Science, Swansea University Medical School, Swansea, UK; Service de Génétique (G.L.), Hospices Civils des Lyon, Bron; GENDEV Team (G.L.), Neurosciences Research Center of Lyon, Bron, France; NIHR University College London Hospitals Biomedical Research Centre (S.M.S.), UCL Institute of Neurology, London, UK; Cologne Center for Genomics (D.L.), University of Cologne, Germany; Stanley Center for Psychiatric Research (D.L.) and Program in Medical and Population Genetics (D.L.), Broad Institute of MIT and Harvard, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit (D.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.

Methods: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007089DOI Listing
February 2019
1 Read

Systematic review finds that fever phobia is a worldwide issue among caregivers and healthcare providers.

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Aim: Fever phobia describes exaggerated concerns about the consequences of childhood fever and broader awareness is needed in everyday clinical practice. We investigated the factors associated with fever phobia in caregivers and healthcare providers and the geographical distribution of the issue.

Methods: The National Library of Medicine and Excerpta Medica databases were searched for papers on fever phobia, excluding those that tackled fever phobia. Read More

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http://dx.doi.org/10.1111/apa.14739DOI Listing
February 2019
1 Read

Mutations in and in a patient with early-onset epileptic encephalopathy and respiratory depression.

Cold Spring Harb Mol Case Stud 2019 Feb 1;5(1). Epub 2019 Feb 1.

Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Early infantile epileptic encephalopathy (EIEE) is a severe disorder associated with epilepsy, developmental delay and intellectual disability, and in some cases premature mortality. We report the case of a female infant with EIEE and strikingly suppressed respiratory dysfunction that led to death. Postmortem research evaluation revealed hypoplasia of the arcuate nucleus of the medulla, a candidate region for respiratory regulation. Read More

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http://dx.doi.org/10.1101/mcs.a003442DOI Listing
February 2019
1 Read

[Vaccination, febrile seizures and epilepsy].

Authors:
E D Belousova

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):67-71

Pirogov Russian National Research Medical University, Moscow, Russia.

This literature review addresses the risk of vaccination complications including neurological ones. Some vaccines associated with vaccine-induced febrile seizures (FS), e.g. Read More

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http://dx.doi.org/10.17116/jnevro201811810267DOI Listing
January 2018
3 Reads

Risk Factors of Recurrence of Febrile Seizures in Children in a Tertiary Care Hospital in Kanpur: A One Year Follow Up Study.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):31-36

Department of Pediatrics, GSVM Medical College, Kanpur, Uttar Pradesh, India.

Background: Febrile seizures are commonly seen in children and about one-third of the children develop a recurrence of febrile seizures.

Objectives: The main objective is to study the risk factors associated with recurrence of febrile seizures in Indian children.

Methods: This prospective, longitudinal study was carried out in the Department of Pediatrics, GSVM Medical College, Kanpur. Read More

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http://dx.doi.org/10.4103/aian.AIAN_472_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327698PMC
January 2019
1 Read

Gene mutations in paediatric epilepsies cause NMDA-pathy, and phasic and tonic GABA-pathy.

Dev Med Child Neurol 2019 Jan 25. Epub 2019 Jan 25.

Inserm U1129, Infantile Epilepsies and Brain Plasticity, CEA Gif/Yvette, Pôle de Recherche et d'Enseignement Supérieur Sorbonne Paris Cité, Paris Descartes University, Paris, France.

The aim of this study was to disentangle mechanisms of epileptogenesis in monogenic epilepsies in children. We reviewed paediatric monogenic epilepsies excluding brain malformation or an inborn error of metabolism, but including the gene function whether there is loss-of-function or gain-of-function, age at gene expression when available, and associated epilepsy syndrome. Genes for which at least five patients with similar epilepsy phenotype had been reported were selected. Read More

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http://doi.wiley.com/10.1111/dmcn.14152
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http://dx.doi.org/10.1111/dmcn.14152DOI Listing
January 2019
4 Reads

Prolonged febrile seizures induce inheritable memory deficits in rats through DNA methylation.

CNS Neurosci Ther 2019 Jan 21. Epub 2019 Jan 21.

Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Aims: Febrile seizures (FSs) are the most common types of seizures in young children. However, little is known whether the memory deficits induced by early-life FSs could transmit across generations or not.

Methods: The memory functions of different generations of FS rats were behaviorally evaluated by morris water maze, inhibitory avoidance task, and contextual fear conditioning task. Read More

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http://doi.wiley.com/10.1111/cns.13088
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http://dx.doi.org/10.1111/cns.13088DOI Listing
January 2019
5 Reads

Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 Feb 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
3 Reads

Reduced cerebrospinal fluid levels of interleukin-10 in children with febrile seizures.

Seizure 2019 Feb 14;65:94-97. Epub 2019 Jan 14.

Pediatric Emergency Unit, Department of Pediatrics, Okmeydani Training and Research Hospital, Istanbul, Turkey.

Purpose: The exact etiology of febrile seizures (FS) is still unclear. However, it is thought that cytokine network activation may have a causative role. Therefore, this study aimed to evaluate the levels of interleukin-12 (IL-12) as a proinflammatory cytokine, interleukin-10 (IL-10) as an anti-inflammatory cytokine, and interferon-β (IFN-β), a marker of toll-like receptor-3 activation as a host response to viruses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183061
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http://dx.doi.org/10.1016/j.seizure.2019.01.008DOI Listing
February 2019
6 Reads

Novel ANKRD11 gene mutation in an individual with a mild phenotype of KBG syndrome associated to a GEFS+ phenotypic spectrum: a case report.

BMC Med Genet 2019 Jan 14;20(1):16. Epub 2019 Jan 14.

Department of Biomedical Science, University of Sassari, Sassari, Italy.

Background: KBG syndrome is a very rare autosomal dominant disorder, characterized by macrodontia, distinctive craniofacial findings, skeletal findings, post-natal short stature, and developmental delays, sometimes associated with seizures and EEG abnormalities. So far, there have been over 100 cases of KBG syndrome reported.

Case Presentation: Here, we describe two sisters of a non-consanguineous family, both presenting generalized epilepsy with febrile seizures (GEFS+), and one with a more complex phenotype associated with mild intellectual disability, skeletal and dental anomalies. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-019-0745-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332862PMC
January 2019
6 Reads

Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico.

PLoS Negl Trop Dis 2019 01 14;13(1):e0007084. Epub 2019 Jan 14.

Centers for Disease Control and Prevention, Dengue Branch, San Juan, Puerto Rico.

Background: Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347300PMC
January 2019
2 Reads

Ascertaining the epidemiology, patient flow and disease management for Dravet syndrome in Spain.

Rev Neurol 2019 Jan;68(2):75-81

Omakase Consulting, Barcelona, Espana.

Introduction: Dravet syndrome (DS) is a rare, drug resistant epilepsy that starts very early in life with febrile seizures followed by cognitive impairment and diverse seizure types.

Aim: To generate evidence on the epidemiology of DS, its diagnosis, patient-flow, treatment and unmet needs from the perspective of Spanish experts.

Development: A two-round Delphi study involving 19 physicians was conducted. Read More

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January 2019
6 Reads

Reduction in recurrence of febrile seizures with paracetamol use.

J Paediatr Child Health 2019 Jan;55(1):116

British Columbia Children's Hospital, Vancouver.

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http://dx.doi.org/10.1111/jpc.14324DOI Listing
January 2019
1 Read

Rheumatoid arthritis presenting as rheumatoid meningitis.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Neurology, Cork University Hospital, Cork, Ireland.

Rheumatoid meningitis (RM) is a rare extra-articular manifestation of rheumatoid arthritis (RA). A 59-year-old man presented with a 10-day history of right-sided frontal headache and a 7-day history of subacute left-sided weakness. He had no history of RA. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22664
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http://dx.doi.org/10.1136/bcr-2018-226649DOI Listing
January 2019
11 Reads

Clinical characteristics and follow-up of benign convulsions with mild gastroenteritis among children.

Medicine (Baltimore) 2019 Jan;98(2):e14082

Benign convulsions with mild gastroenteritis have a high incidence in the North China, previous reports it has been caused by rotavirus infection, which is a non-febrile convulsion. In recent years, we observed that norovirus infection gradually increased all the years round and most of them are febrile convulsion.Retrospective analysis was performed on 55 pediatric patients with benign convulsions with mild gastroenteritis (CWG) who were admitted between January 2010 and January 2015. Read More

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http://dx.doi.org/10.1097/MD.0000000000014082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336632PMC
January 2019

Neurodevelopmental problems should be considered in children with febrile seizures.

Acta Paediatr 2019 Jan 7. Epub 2019 Jan 7.

Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg and Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

Aim: Clinical developmental phenotyping of four- to five-year-old children with febrile seizures (FSs).

Methods: Children with FS (n = 157, corresponding to 3.7% of the targeted general population of four-five-year-olds) had been identified at child healthcare centres in Gothenburg. Read More

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http://doi.wiley.com/10.1111/apa.14716
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http://dx.doi.org/10.1111/apa.14716DOI Listing
January 2019
5 Reads

Increased von Willebrand factor parameters in children with febrile seizures.

PLoS One 2019 3;14(1):e0210004. Epub 2019 Jan 3.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Introduction: Primary blood coagulation and wound sealing are orchestrated by von Willebrand factor (VWF), a large multimeric glycoprotein. Upon release of arginine vasopressin (AVP), VWF containing high molecular weight multimers is secreted. By measuring copeptin, the C-terminal part of the AVP prohormone, we recently found strongly increased AVP levels in children with febrile seizures (FS) as compared to children with fever but without seizures. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210004PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317815PMC
January 2019
1 Read

Febrile seizures: Are they truly benign? Longitudinal analysis of risk factors and future risk of afebrile epileptic seizure based on the national sample cohort in South Korea, 2002-2013.

Seizure 2019 Jan 11;64:77-83. Epub 2018 Dec 11.

Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Purpose: We performed a large, population-based study to analyze the risk factors of the febrile seizures and the subsequent afebrile epileptic seizures.

Methods: Relevant data from children born between 2002-2007 were retrieved from the Korean National Health Insurance Service-National Sample Cohort 2002-2013. Children who did not survive the first five years were excluded from the analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183044
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http://dx.doi.org/10.1016/j.seizure.2018.12.004DOI Listing
January 2019
9 Reads

Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency.

Epileptic Disord 2018 Dec;20(6):545-550

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University,, Department of Neurology and Neurosurgery, McGill University,, Research Institute of the McGill University Health Centre.

Hemiconvulsion-Hemiplegia-Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ep
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http://dx.doi.org/10.1684/epd.2018.1017DOI Listing
December 2018
7 Reads

Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study.

Lancet Child Adolesc Health 2019 Feb 7;3(2):99-108. Epub 2018 Dec 7.

National Center for Register-Based Research, Aarhus University, Aarhus, Denmark; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Background: Paediatric seizures have been linked to psychiatric disorders in childhood, but there is a paucity of large-scale population-based studies of psychiatric comorbidity in later life. We aimed to examine the relation between childhood seizures and the risk of psychiatric disorders in adolescence and early adulthood.

Methods: We did a register-based cohort study of all individuals born in Denmark in 1978-2002. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30351-1DOI Listing
February 2019

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department.

J Pediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the proportion of children presenting to the emergency department (ED) with altered mental status who demonstrate nonconvulsive seizures on reduced-lead electroencephalography (EEG), and to further investigate the characteristics, treatment, and outcomes in these patients compared with patients without nonconvulsive seizures.

Study Design: In this retrospective cohort study, we reviewed the database and medical records of pediatric patients (aged <18 years) in a single ED between May 1, 2016, and April 30, 2018. We first determined the proportion of nonconvulsive seizures among patients with altered mental status (Glasgow Coma Scale <15). Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.11.019DOI Listing
December 2018
1 Read

Outcomes and comorbidities of SCN1A-related seizure disorders.

Epilepsy Behav 2019 Jan 5;90:252-259. Epub 2018 Dec 5.

Department of Genetics, University Medical Center Utrecht, Utrecht University, the Netherlands.

Purpose: Differentiating between Dravet syndrome and non-Dravet SCN1A-related phenotypes is important for prognosis regarding epilepsy severity, cognitive development, and comorbidities. When a child is diagnosed with genetic epilepsy with febrile seizures plus (GEFS+) or febrile seizures (FS), accurate prognostic information is essential as well, but detailed information on seizure course, seizure freedom, medication use, and comorbidities is lacking for this milder patient group. In this cross-sectional study, we explore disease characteristics in milder SCN1A-related phenotypes and the nature, occurrence, and relationships of SCN1A-related comorbidities in both patients with Dravet and non-Dravet syndromes. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.09.041DOI Listing
January 2019

New onset refractory status epilepticus (NORSE).

Seizure 2018 Sep 29. Epub 2018 Sep 29.

Département de Neurologie, Université Libre de Bruxelles, Hôpital Erasme, Brussels, Belgium; Comprehensive Epilepsy Center, Neurology Department, Yale University School of Medicine, New Haven, CT, USA.

Purpose: To summarize the clinical features, suggested work-up, treatment and prognosis of new-onset refractory status epilepticus (NORSE), a condition recently defined as the occurrence of refractory status epilepticus (RSE) in a patient without active epilepsy, and without a clear acute or active structural, toxic or metabolic cause; and of the related syndrome of febrile infection-related epilepsy syndrome (FIRES), also recently defined as a subgroup of NORSE preceded by a febrile illness between 2 weeks and 24 h prior to the onset of RSE.

Method: Narrative review of the medical literature about NORSE and FIRES.

Results: NORSE and FIRES mainly affect school-age children and young adults. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.018DOI Listing
September 2018
12 Reads

Similar relative risks of seizures following measles containing vaccination in children born preterm compared to full-term without previous seizures or seizure-related disorders.

Vaccine 2019 Jan 23;37(1):76-79. Epub 2018 Nov 23.

Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA.

Background: Febrile seizures are associated with the first dose of measles-containing vaccines and the risk increases with chronologic age during the second year of life. We used the Vaccine Safety Datalink (VSD) to determine if the relative increase in risk of seizures following receipt of measles-containing vaccine differs by gestational age at birth.

Methods: Children were eligible if they received their first dose of measles-containing vaccine at age 12 through 23 months from January 2003 through September 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183156
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http://dx.doi.org/10.1016/j.vaccine.2018.11.038DOI Listing
January 2019
9 Reads

Thermoregulation in epilepsy.

Handb Clin Neurol 2018 ;157:737-747

Departments of Neurological Sciences, Neurosurgery, Medicine, and Anesthesiology, Rush Medical College, Chicago, IL, United States; Clinical Neurophysiology Laboratory, Rush University Medical Center, Chicago, IL, United States.

Several aspects of thermoregulation play a role in epilepsy. Circuitries involved in thermoregulation are affected by seizures and epilepsy, hyperthermia may be both cause and result of seizures, and hypothermia may prevent or abort seizures. Autonomic manifestations of seizures including thermoregulatory disturbances are common in a variety of clinical epilepsy syndromes. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00045-8DOI Listing
January 2018
2 Reads

Diagnostics and treatment of children with acute seizures on paediatric intensive care unit.

Cas Lek Cesk 2018 ;157(3):130-132

218 children were admitted to paediatric clinic for acute seizures within last 5 years. Out of them, 14 children (7%) were admitted to paediatric intensive care unit (PICU) with repeated or prolonged seizures. Two children were hospitalized twice. Read More

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January 2018
1 Read

Electroencephalography in Pediatric Epilepsy.

Indian Pediatr 2018 Oct;55(10):893-901

Department of Pediatrics, BL Kapur Superspeciality Hospital, Delhi; India.

Surface electroencephalography (EEG) is a useful electrophysiological investigation for evaluating a paroxysmal event in children. It measures the electro potential difference between two points on the scalp. It is a non-invasive tool that analyzes neuronal maturation and abnormal cortical excitability. Read More

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October 2018
3 Reads

Neurologic Alterations Due to Respiratory Virus Infections.

Front Cell Neurosci 2018 26;12:386. Epub 2018 Oct 26.

Millennium Institute on Immunology and Immunotherapy (MIII), Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Central Nervous System (CNS) infections are one of the most critical problems in public health, as frequently patients exhibit neurologic sequelae. Usually, CNS pathologies are caused by known neurotropic viruses such as measles virus (MV), herpes virus and human immunodeficiency virus (HIV), among others. However, nowadays respiratory viruses have placed themselves as relevant agents responsible for CNS pathologies. Read More

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http://dx.doi.org/10.3389/fncel.2018.00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212673PMC
October 2018
1 Read

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2019 Feb 6;205:130-137. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
February 2019
18 Reads

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2019 Feb;38(2):181-188

University of Tampere Medical School, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
February 2019
5 Reads

[Clinical characteristics and genetic features of benign infantile epilepsy with PRRT2 mutation].

Zhonghua Er Ke Za Zhi 2018 Nov;56(11):818-823

Department of Neurology, National Center for Children's Health (Beijing) , Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.

To summarize the detailed clinical characteristics and genetic features of benign infantile epilepsy with PRRT2 mutation, in order to improve the understanding of the disease. The clinical data and genetic results of 40 benign infantile epilepsy patients with PRRT2 mutation who were diagnosed and treated in the neurology department of National Center for Children's Health (Beijing) , Beijing Children's Hospital affiliated to Capital Medical University from January 2002 to October 2017 and their affected family members were analyzed. Forty benign infantile epilepsy patients were recruited for this study, with 18 males and 22 females. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.11.005DOI Listing
November 2018
8 Reads

Myelin water fraction changes in febrile seizures.

Clin Neurol Neurosurg 2018 Dec 10;175:61-67. Epub 2018 Oct 10.

Division of Pediatric Neurosurgery, Joe DiMaggio Children's Hospital, 1150N 35th Ave, Hollywood, FL, 33021, USA. Electronic address:

Objective: The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.

Patients And Methods: As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences-T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)-and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183040
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http://dx.doi.org/10.1016/j.clineuro.2018.10.005DOI Listing
December 2018
4 Reads

Respiratory Syncytial Virus-Associated Seizures in Korean Children during 2011/01 -2016/12.

Korean J Pediatr 2018 Oct 23. Epub 2018 Oct 23.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, Republic of Korea.

Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that are presented with seizures.

Methods: We retrospectively reviewed the medical records of patients younger than 15 years who had laboratory-confirmed RSV infections and seizures from January 2011 to December 2016 in a regional hospital in South Korea. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.07066
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http://dx.doi.org/10.3345/kjp.2018.07066DOI Listing
October 2018
2 Reads

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.

Brain 2018 Nov;141(11):3160-3178

EuroEPINOMICS RES Consortium.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segregating with epilepsy in 14 individuals, but not penetrant in six additional individuals. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy263DOI Listing
November 2018
34 Reads

Assessment of physicians knowledge and attitudes in the management of febrile seizures.

Neurosciences (Riyadh) 2018 Oct;23(4):314-319

Division of Neurology, Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail:

Objective: To assess the knowledge and attitudes of physicians in different specialties who are involved in the care of children with FS.

Methods: We assessed knowledge and attitudes in the management of Febrile seizure (FS) among physicians working in different specialties in the Kingdom of Saudi Arabia using a questionnaire-based cross-sectional study conducted from September-December 2016.

Results: Of the 300 physicians who responded to the questionnaire, 178 (59. Read More

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http://dx.doi.org/10.17712/nsj.2018.4.20180097DOI Listing
October 2018
14 Reads
0.391 Impact Factor

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study.

Front Neurol 2018 5;9:834. Epub 2018 Oct 5.

Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States.

One third of children with epilepsy are refractory to medications. Growing data support a role of common childhood infections with neurotropic viruses and inflammation in epileptogenesis. Our objective was to determine the frequency of Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) infection and cytokine levels in saliva from children with seizures compared to healthy controls and to controls with a febrile illness without seizures. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00834
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http://dx.doi.org/10.3389/fneur.2018.00834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182262PMC
October 2018
4 Reads

Association between Adverse Effects and Parental Beliefs about Antiepileptic Medicines.

Medicina (Kaunas) 2018 Aug 28;54(4). Epub 2018 Aug 28.

Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.

Adverse effects are common in children treated with antiepileptic medications and may affect parental beliefs about treatment. The aim of the study was to investigate the relationship between adverse effects and parental beliefs about antiepileptic drugs used for the treatment of their children. The study was performed at the University Children's Hospital, Belgrade, Serbia from 2013⁻2015. Read More

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http://dx.doi.org/10.3390/medicina54040060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174341PMC
August 2018
10 Reads

Seizures, Meds, and Vtach: A Journey to a Brugada Diagnosis.

Pediatr Emerg Care 2018 Oct 17. Epub 2018 Oct 17.

Arkansas College of Osteopathic Medicine, Fort Smith, AR.

Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001640DOI Listing
October 2018
11 Reads

Acute encephalopathy with biphasic seizures and late reduced diffusion accompanied by Takotsubo cardiomyopathy.

Brain Dev 2018 Oct 13. Epub 2018 Oct 13.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is characterized by biphasic seizures and impaired consciousness. Takotsubo cardiomyopathy (TTC), which is typically triggered by psychological or physical stress, is characterized by transient myocardial dysfunction affecting the left ventricular apex. Recent reports have suggested that seizures can also trigger TTC. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.10.002DOI Listing
October 2018
2 Reads

Management of Pediatric Febrile Seizures.

Int J Environ Res Public Health 2018 10 12;15(10). Epub 2018 Oct 12.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza L. Severi 1, 06132 Perugia, Italy.

Febrile seizures (FS), events associated with a fever in the absence of an intracranial infection, hypoglycaemia, or an acute electrolyte imbalance, occur in children between six months and six years of age. FS are the most common type of convulsions in children. FS can be extremely frightening for parents, even if they are generally harmless for children, making it important to address parental anxiety in the most sensitive manner. Read More

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http://dx.doi.org/10.3390/ijerph15102232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210946PMC
October 2018
2 Reads

The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.

Sci Rep 2018 Oct 11;8(1):15123. Epub 2018 Oct 11.

Department of pediatrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Foshan, Guangdong, 528000, China.

Systemic inflammatory response has been implicated as a contributor to the onset of febrile seizures (FS). The four novel indices of the inflammatory response such as, neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet count (PLT) ratio and red blood cell distribution width (RDW) have been investigated in FS susceptibility and FS types (simple febrile seizure and complex febrile seizure). However, the potential role of these inflammatory markers and MPV/PLT ratio (MPR) in Chinese children with FS has yet to be fully determined. Read More

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http://www.nature.com/articles/s41598-018-33373-3
Publisher Site
http://dx.doi.org/10.1038/s41598-018-33373-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181908PMC
October 2018
3 Reads

Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode.

Pediatrics 2018 Nov 8;142(5). Epub 2018 Oct 8.

Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan.

Objectives: To confirm the safety of using acetaminophen for febrile seizures (FSs) and to assess its efficacy in preventing FS recurrence during the same fever episode.

Methods: In this single-center, prospective, open, randomized controlled study, we included children and infants (age range: 6-60 months) with FSs who visited our hospital between May 1, 2015, and April 30, 2017. The effectiveness of acetaminophen was examined by comparing the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38. Read More

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http://dx.doi.org/10.1542/peds.2018-1009DOI Listing
November 2018
3 Reads

Fangjing decoction relieves febrile seizures-induced hippocampal neuron apoptosis in rats via regulating the Akt/mTOR pathway.

Biosci Rep 2018 10 31;38(5). Epub 2018 Oct 31.

Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou 310002, China.

: Fangjing decoction is a Traditional Chinese Medicine that exhibits anticonvulsive effects in treating febrile seizures (FS). Its action mechanism and the regulation on Akt/mammalian target of rapamycin (mTOR) pathway were revealed in the present study.: FS model was established in Sprague-Dawley rats with or without Fangjing decoction treatment. Read More

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http://dx.doi.org/10.1042/BSR20181206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209604PMC
October 2018

[Fatal spotted fever in Salta province].

Medicina (B Aires) 2018 ;78(5):356-359

Departamento de Medicina Interna y Terapia Intensiva, Hospital Papa Francisco, Salta, Argentina. E-mail:

We describe the case of a 17-year-old male patient living in Salta city who, 10 days after visiting a rural area in Salta province, was hospitalized for febrile seizures. Shortly after admission, he developed an exanthema followed by a multiple organ dysfunction that evolved to irreversible septic shock followed by death 48 hours after admission. Serological diagnosis -high IgM and IgG anti-Rickettsia spp. Read More

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January 2018
17 Reads

Cerebral Hydatid Cyst in a Young Immunocompromised Patient in Parakou.

J Neurosci Rural Pract 2018 Oct-Dec;9(4):622-624

Department of Neurology, Faculty of Medicine, University of Parakou, Parakou, Benin.

We report the case of a 30-year-old human immunodeficiency virus (HIV)-positive HIV patient who was poorly followed. She was admitted on November 30, 2017, for the management of febrile encephalitis syndrome with motor deficit of the left hemicorps and generalized seizures. In biology, we found a nonspecific inflammatory syndrome. Read More

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http://www.ruralneuropractice.com/text.asp?2018/9/4/622/2398
Publisher Site
http://dx.doi.org/10.4103/jnrp.jnrp_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126280PMC
October 2018
1 Read