5,297 results match your criteria Febrile Seizures


TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.

Proc Natl Acad Sci U S A 2021 May;118(20)

Department of Physiology, University of California, San Francisco, CA 94158;

Febrile seizures (FSs) are the most common convulsion in infancy and childhood. Considering the limitations of current treatments, it is important to examine the mechanistic cause of FSs. Prompted by a genome-wide association study identifying TMEM16C (also known as ANO3) as a risk factor of FSs, we showed previously that loss of TMEM16C function causes hippocampal neuronal hyperexcitability [Feenstra , Nat. Read More

View Article and Full-Text PDF

Exploring Variances of White Matter Integrity and the Glymphatic System in Simple Febrile Seizures and Epilepsy.

Front Neurol 2021 21;12:595647. Epub 2021 Apr 21.

Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Simple febrile seizures (SFS) and epilepsy are common seizures in childhood. However, the mechanism underlying SFS is uncertain, and the presence of obvious variances in white matter (WM) integrity and glymphatic function between SFS and epilepsy remain unclear. Therefore, this study aimed to investigate the differences in WM integrity and glymphatic function between SFS and epilepsy. Read More

View Article and Full-Text PDF

Post-licensure observational safety study after meningococcal B vaccine 4CMenB (Bexsero) vaccination within the routine UK immunisation program.

Vaccine 2021 May 4. Epub 2021 May 4.

Global Clinical and Epidemiology R&D, GSK, 1101 CL Amsterdam, Netherlands. Electronic address:

The study investigated the safety of 4-component meningococcal serogroup B vaccination (4CMenB) in routine care. 4CMenB exposure and seizures, febrile seizures and Kawasaki disease were identified from The Health Improvement Network (THIN) database of UK electronic primary healthcare records, 2015-2018. A self-controlled case series analysis was completed. Read More

View Article and Full-Text PDF

The Fetus with Ganglionic Eminence Abnormality: Head Size and Extracranial Sonographic Findings Predict Genetic Diagnoses and Postnatal Outcomes.

AJNR Am J Neuroradiol 2021 May 6. Epub 2021 May 6.

Department of Pediatric Radiology and Neuroradiology (A.R.), Vittore Buzzi Children's Hospital, Milan, Italy.

Background And Purpose: Ganglionic eminence abnormalities on fetal MR imaging are associated with cerebral malformations. Their presumed genetic basis and associated postnatal outcomes remain largely unknown. We aimed to elucidate these through a multicenter study. Read More

View Article and Full-Text PDF

ACR Appropriateness Criteria® Seizures-Child.

J Am Coll Radiol 2021 May;18(5S):S199-S211

Specialty Chair, Riley Hospital for Children Indiana University, Indianapolis, Indiana.

In children, seizures represent an extremely heterogeneous group of medical conditions ranging from benign cases, such as a simple febrile seizure, to life-threatening situations, such as status epilepticus. Underlying causes of seizures also represent a wide range of pathologies from idiopathic cases, usually genetic, to a variety of acute and chronic intracranial or systemic abnormalities. This document discusses appropriate utilization of neuroimaging tests in a child with seizures. Read More

View Article and Full-Text PDF

T cell numbers correlate with neuronal loss rather than with seizure activity in medial temporal lobe epilepsy.

Epilepsia 2021 May 6. Epub 2021 May 6.

Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Objective: Medial temporal lobe epilepsy (MTLE) is a drug-resistant focal epilepsy that can be caused by a broad spectrum of different inciting events, including tumors, febrile seizures, and viral infections. In human epilepsy surgical resections as well as in animal models, an involvement of the adaptive immune system was observed. We here analyzed the presence of T cells in various subgroups of MTLE. Read More

View Article and Full-Text PDF

Modeling seizures in the Human Phenotype Ontology according to contemporary ILAE concepts makes big phenotypic data tractable.

Epilepsia 2021 May 5. Epub 2021 May 5.

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: The clinical features of epilepsy determine how it is defined, which in turn guides management. Therefore, consideration of the fundamental clinical entities that comprise an epilepsy is essential in the study of causes, trajectories, and treatment responses. The Human Phenotype Ontology (HPO) is used widely in clinical and research genetics for concise communication and modeling of clinical features, allowing extracted data to be harmonized using logical inference. Read More

View Article and Full-Text PDF

A Survey of Caregivers' Knowledge on Detection and Management of Pediatric Fever.

Cureus 2021 Mar 31;13(3):e14222. Epub 2021 Mar 31.

Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, USA.

Introduction Fever is a common presenting symptom for children accounting for over 20% of visits to the emergency department (ED). The symptom of fever in children has been shown to create undue anxiety amongst caregivers. The purpose of this study was to evaluate caregivers' detection and management of pediatric fevers to identify potential knowledge gaps in our patient population. Read More

View Article and Full-Text PDF

Variant in A 3-Year-Old-An Expanding Spectrum?

Neurol Int 2021 Apr 29;13(2):184-189. Epub 2021 Apr 29.

"Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Glutamate, the major excitatory neurotransmitter, plays a ubiquitous role in most aspects of normal brain functioning. Its indispensable position is paradoxically doubled by a high excitotoxic potential following disruption of its dynamic equilibrium. Several lines of evidence have suggested the involvement of the glutamatergic N-methyl-D-aspartate receptor (NMDAR) in learning, memory formation, and human cognition. Read More

View Article and Full-Text PDF

Association of Iron Deficiency Anemia with Febrile Seizure in Children in a Tertiary Care Hospital.

J Nepal Health Res Counc 2021 Apr 23;19(1):66-70. Epub 2021 Apr 23.

Department of Pediatrics, College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal.

Background: Febrile seizure is the most common cause of seizure in children. Iron deficiency, by lowering seizure threshold, is proposed to be one of the risk factors for febrile seizure. Many studies have been done to determine the association of iron deficiency anemia with febrile seizure but the results are controversial. Read More

View Article and Full-Text PDF

Parameters Indicating Development of Influenza-Associated Acute Necrotizing Encephalopathy: Experiences from a Single Center.

Med Sci Monit 2021 May 2;27:e930688. Epub 2021 May 2.

Department of Pediatric Neurology, Guangzhou Women's and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Influenza-associated acute necrotizing encephalopathy (IANE) can be lethal and disabling and have a sudden onset and deteriorate rapidly but lacks early diagnostic indicators. We aimed to examine the early clinical diagnostic indicators in children with IANE. MATERIAL AND METHODS Acute influenza patients were grouped according to their clinical manifestations: flu alone (FA), flu with febrile seizure (FS), influenza-associated encephalopathy (IAE), and IANE. Read More

View Article and Full-Text PDF

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

Seizure 2021 Apr 9;88:146-152. Epub 2021 Apr 9.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China; Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, China. Electronic address:

Purpose: To explore disease-causing gene mutations of epilepsy with febrile seizures plus (EFS+) in Southern Chinese Han population.

Methods: Blood samples and clinical data were collected from 49 Southern Han Chinese patients with EFS+. Gene screening was performed using whole-exome sequencing and panel sequencing for 485 epilepsy-related genes. Read More

View Article and Full-Text PDF

UNC13B variants associated with partial epilepsy with favourable outcome.

Brain 2021 Apr 20. Epub 2021 Apr 20.

Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

The unc-13 homolog B (UNC13B) gene encodes a presynaptic protein, mammalian uncoordinated 13-2 (Munc13-2), that is highly expressed in the brain-predominantly in the cerebral cortex-and plays an essential role in synaptic vesicle priming and fusion, potentially affecting neuronal excitability. However, the functional significance of UNC13B mutation in human disease is not known. In this study we screened for novel genetic variants in a cohort of 446 unrelated cases (families) with partial epilepsy without acquired causes by trio-based whole-exome sequencing. Read More

View Article and Full-Text PDF

Consensus statements on the information to deliver after a febrile seizure.

Eur J Pediatr 2021 Apr 17. Epub 2021 Apr 17.

APHP. Service de Neurologie Pédiatrique, Hôpital Robert Debré, Paris, France.

Febrile seizures (FS) are usually self-limiting and cause no morbidity. Nevertheless they represent very traumatic events for families. There is a need to identify key messages that reassure carers and help to prevent inappropriate, anxiety-driven behaviors associated with "fever phobia. Read More

View Article and Full-Text PDF

Temporal-parietal-occipital epilepsy in GEFS+ associated with SCN1A mutation.

Epileptic Disord 2021 Apr 12. Epub 2021 Apr 12.

Department of Neuroscience, Reproductive and Odontostomatological Sciences, Federico II University, Napoli, Italy.

Most families with genetic epilepsy with febrile seizures plus show a mutation in the sodium channel alpha 1 subunit gene, however, but there is much phenotypic heterogeneity and focal epilepsy remains relatively rare. Here, we report a family with electroclinical features indicative of temporal-parietal-occipital carrefour epilepsy with common occurrence of post-ictal migraine. We studied a four-generation family including nine affected subjects by means of EEG and MRI. Read More

View Article and Full-Text PDF

[Dynamic change of hippocampal volume in children with recurrent febrile seizures].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):350-355

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Objective: To study the change and significance of hippocampal volume (HCV) in children with recurrent febrile seizures.

Methods: A retrospective analysis was performed on the medical data and examination results of 34 children with recurrent febrile seizures who underwent two magnetic resonance plain scans of the head and the hippocampus from January 1, 2013 to September 30, 2019. According to the follow-up time, they were divided into the first follow-up group and the second follow-up group. Read More

View Article and Full-Text PDF

Electroclinical features of MEF2C haploinsufficiency-related epilepsy: A multicenter European study.

Seizure 2021 Mar 30;88:60-72. Epub 2021 Mar 30.

Maternal and Pediatric Department, Fondazione IRCCS Casa Sollievo della Sofferenza, Poliambulatorio "Giovanni Paolo II", Viale Padre Pio, snc, San Giovanni Rotondo (FG) 71013, Italy.

Purpose: Epilepsy is a main manifestation in the autosomal dominant mental retardation syndrome caused by heterozygous variants in MEF2C. We aimed to delineate the electro-clinical features and refine the genotype-phenotype correlations in patients with MEF2C haploinsufficiency.

Methods: We thoroughly investigated 25 patients with genetically confirmed MEF2C-syndrome across 12 different European Genetics and Epilepsy Centers, focusing on the epileptic phenotype. Read More

View Article and Full-Text PDF

Birth characteristics and risk of febrile seizures.

Acta Neurol Scand 2021 Apr 6. Epub 2021 Apr 6.

Department of Economics and Business Economics, National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark.

Objective: Febrile seizure is a common childhood disorder that affects 2-5% of all children, and is associated with later development of epilepsy and psychiatric disorders. This study determines how the incidence of febrile seizures correlates with birth characteristics, age, sex and brain development.

Methods: This is a cohort study of all children born Denmark between 1977 and 2011 who were alive at 3 months of age (N = 2,103,232). Read More

View Article and Full-Text PDF

A Mutation in the SCN1A Gene With a Peculiar Course: A Case Report.

Cureus 2021 Feb 28;13(2):e13612. Epub 2021 Feb 28.

Pediatrics, Emergency Clinical Hospital for Children, Cluj-Napoca, ROU.

In this report, we present the case of a one-year-old female patient with a history of febrile seizures, which was characterized by multiple seizures during hot baths and more than one episode of status epilepticus. Dravet syndrome was suspected due to the clinical context of the seizures and was confirmed by genetic testing. The brain MRI was found to be normal. Read More

View Article and Full-Text PDF
February 2021

Cognitive and behavioural development in children presenting with complex febrile seizures: at onset and school age.

Epileptic Disord 2021 Apr 2. Epub 2021 Apr 2.

Department of Psychology, University of Montreal, Marie Victorin Building, 90 Vincent-D'Indy Avenue, Montreal, Quebec, H2V 2S9, Canada, CHU Sainte-Justine, 3175 Côte Ste-Catherine, Montreal, Qc., H3T 1C5, Canada.

Objective: Our goal was to assess development, cognition and behaviour following an initial complex febrile seizure (FS), at onset and school age, in the context of known risk factors for cognitive development.

Methods: Two cohorts were recruited. Thirty-five infants with an initial complex FS were assessed within the first year post-seizure and compared to 30 controls (simple FS) based on measures of cognitive, motor and language development, behaviour and emotions. Read More

View Article and Full-Text PDF

Febrile Seizures: Evidence for Evolution of an Operational Strategy from an Armed Forces Referral Hospital.

Pediatric Health Med Ther 2021 25;12:151-159. Epub 2021 Mar 25.

Medical Officer, Emergency Department, Command Hospital (Northern Command), Jammu & Kashmir, India.

Purpose: Current recommendations for 'Febrile seizures' management include emergency first aid and treatment along with intermittent prophylaxis. Evidence of practices, efficacy, side-effects, and complications should lead to refined and rational management strategies.

Patients And Methods: Study of cases referred and treated at a tertiary level hospital, providing referral services to a large state in India. Read More

View Article and Full-Text PDF

Ifosfamide-related encephalopathy with severe clinical presentations in children with cancer.

J Oncol Pharm Pract 2021 Mar 27:10781552211005533. Epub 2021 Mar 27.

Department of Pediatrics, Division of Pediatric Oncology, Ege University School of Medicine, Izmir, Turkey.

Introduction: Ifosfamide is an alkylating agent, mostly used against variety of solid tumors in pediatric oncology practice. Although hemorrhagic cystitis is known as a common adverse effect, encephalopathy is the another one that should be kept in mind. It may occur in 2-5% of the children, and manifested by different clinical spectrums such as somnolence, lethargy, irritability, excitement, disorientation, confusion, weakness, hallucinations, seizures, movement disorders, and coma. Read More

View Article and Full-Text PDF

Dietary Management of Children With Super-Refractory Status Epilepticus: A Systematic Review and Experience in a Single UK Tertiary Centre.

Front Neurol 2021 12;12:643105. Epub 2021 Mar 12.

Developmental Neurosciences Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.

Ketogenic diet therapies (KDT) are high-fat, low carbohydrate diets used as an effective treatment option for drug-resistant epilepsy. There is limited research on the efficacy of KDT for super-refractory status epilepticus (SRSE). We systematically review evidence for use of KDT in children with SRSE and present a single UK tertiary centre's experience. Read More

View Article and Full-Text PDF

Body temperature predicts recurrent febrile seizures in the same febrile illness.

Brain Dev 2021 Mar 25. Epub 2021 Mar 25.

Division of Neurology, Saitama Children's Medical Center, Saitama, Japan.

Background: The incidence of recurrent febrile seizures during the same febrile illness (RFS) is 14-24%. A pilot study found that body temperature and male sex were predictors of RFS. This study sought to validate body temperature as a predictor of RFS, calculate the optimal cut-off body temperature for predicting RFS, and identify the other predictors of RFS. Read More

View Article and Full-Text PDF

Epilepsy phenotypes associated with MAP1B-related brain malformations.

Epileptic Disord 2021 Mar 26. Epub 2021 Mar 26.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Recently, studies on whole-exome sequencing (WES) of large cohorts of people with periventricular heterotopia (PVH) have reported an association with loss-of-function variants in the MAP1B gene. However, neurological phenotypes of these patients remain poorly characterized. Four family members with seizures beginning in early childhood were evaluated. Read More

View Article and Full-Text PDF

Mutations Cause Childhood Myoclonic Epilepsy and Febrile Seizures: Molecular Sub-regional Effect and Mechanism.

Front Genet 2021 9;12:632466. Epub 2021 Mar 9.

Department of Neurology, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

, which encodes an adapter protein 14-3-3γ, is highly expressed in the brain and regulates a diverse range of cell signaling pathways. Previously, eight mutations have been identified in patients with epileptic encephalopathy (EE). In this study, using trios-based whole exome sequencing, we identified two novel mutations in two unrelated families with childhood myoclonic epilepsy and/or febrile seizures (FS). Read More

View Article and Full-Text PDF

Radiological manifestation of familial acute necrotizing encephalopathy with RANBP2 mutation in a Far-East Asian family: Case report.

Medicine (Baltimore) 2021 Mar;100(12):e25171

Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine, Yangsan, Korea.

Rationale: Acute necrotizing encephalopathy (ANE) is a specific type of encephalopathy usually followed by febrile infection. It has an aggressive clinical course; however, it usually does not recur after recovery in cases of spontaneous ANE. Nevertheless, there are several studies reporting recurrences in familial ANE with RAN-binding protein 2 (RANBP2) mutation. Read More

View Article and Full-Text PDF

The Utility of Infectious and Neurodiagnostic Testing in Children With Complex Febrile Seizures Requiring Mechanical Ventilation.

J Child Neurol 2021 Mar 23:8830738211000507. Epub 2021 Mar 23.

Department of Pediatrics, 8784University of California, San Diego, CA, USA.

A retrospective cohort analysis was performed on 79 consecutive patients between 6 months and 5 years admitted to a tertiary hospital with a diagnosis of complex febrile seizures requiring mechanical ventilation from 2011 to 2017 to determine the utility of infectious and neurologic diagnostics. Intubation was used as a proxy for severity of illness. The overall intensive care unit stay was short (95% intubated <24 hours, 88% admitted <3 days). Read More

View Article and Full-Text PDF

Acute necrotizing encephalopathy of childhood: a single-center experience

Turk J Med Sci 2021 04 30;51(2):706-715. Epub 2021 Apr 30.

Department of Pediatric Neurology, Faculty of Medicine, Dr Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, Turkey

Background/aim: Acute necrotizing encephalopathy is a rare type of acute encephalopathy characterized by multi-ocal brain lesions and associated severe neurological findings and various organ dysfunctions may accompany it.

Materials And Methods: Patients with acute necrotizing encephalopathy of childhood diagnosed by pediatric neurology and pediatric intensive care at Sami Ulus Maternity, Child Health and Diseases Training and Research Hospital between 2007 and 2020 were included in this study.

Results: Nine patients (six females, three males) with a mean age of 4. Read More

View Article and Full-Text PDF