4,858 results match your criteria Febrile Seizures


Childhood epilepsy with a small number of seizures may be left untreated: an international prospective study.

Epileptic Disord 2019 Apr;21(2):141-153

Department of Paediatrics, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada.

It is unknown whether treatment with antiepileptic drugs in children with epilepsy with a presumed good prognosis is always necessary. We aimed to study the course of newly diagnosed epilepsy in children with a presumed good prognosis who are managed without AED treatment. A total of 151 children (one month to 12 years of age) with two to five lifetime unprovoked seizures (excluding febrile convulsions), were followed for three years. Read More

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http://dx.doi.org/10.1684/epd.2019.1040DOI Listing

Fever and Seizure in a Young Infant: A Simulation Case.

MedEdPORTAL 2016 Sep 28;12:10468. Epub 2016 Sep 28.

Professor of Pediatrics, University of Vermont College of Medicine.

Introduction: Fever in early infancy is a common problem for which management can be challenging. All residents need to be able to recognize critical illness such as meningitis in febrile infants and manage complications such as seizures. Many new residents are not competent performing bedside procedures as there is little opportunity to perform them while in medical school. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464472PMC
September 2016

Intelligence and memory outcomes within 10 years of childhood convulsive status epilepticus.

Epilepsy Behav 2019 Apr 18;95:18-25. Epub 2019 Apr 18.

Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK.

Long-term intelligence and memory outcomes of children post convulsive status epilepticus (CSE) have not been systematically investigated despite evidence of short-term impairments in CSE. The present study aimed to describe intelligence and memory outcomes in children within 10 years of CSE and identify potential risk factors for adverse outcomes. In this cohort study, children originally identified by the population-based North London Convulsive Status Epilepticus in Childhood Surveillance Study (NLSTEPSS) were prospectively recruited between July 2009 and February 2013 and invited for neuropsychological assessments and magnetic resonance imaging (MRI) scans. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.039DOI Listing

Genetic and phenotypic characteristics of SCN1A-related epilepsy in Chinese children.

Neuroreport 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Children's Hospital of Chongqing Medical University.

SCN1A gene mutations are associated with epilepsy and neurodevelopmental disorders. This study aimed to explore the genotype and phenotype spectrum of SCN1A gene related epilepsy. Epileptic patients who were treated in the Children's Hospital of Chongqing Medical University from January 2015 to July 2018 and identified as having SCN1A mutations by targeted next-generation sequencing were included. Read More

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http://Insights.ovid.com/crossref?an=00001756-900000000-9814
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http://dx.doi.org/10.1097/WNR.0000000000001259DOI Listing
April 2019
1 Read

Novel variants and phenotypes widen the phenotypic spectrum of GABRG2-related disorders.

Seizure 2019 Mar 19;69:99-104. Epub 2019 Mar 19.

PEDEGO Research Unit, University of Oulu, Oulu, Finland; Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Division of Pediatric Neurology, Oulu University Hospital, Oulu, Finland.

Purpose: Next-generation sequencing (NGS) has made genetic testing of patients with epileptic encephalopathies easier - novel variants are discovered and new phenotypes described. Variants in the same gene - even the same variant - can cause different types of epilepsy and neurodevelopmental disorders. Our aim was to identify the genetic causes of epileptic encephalopathies in paediatric patients with complex phenotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311173083
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http://dx.doi.org/10.1016/j.seizure.2019.03.010DOI Listing
March 2019
1 Read

Postvaccination Febrile Seizure Severity and Outcome.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, Australia.

Background: Febrile seizures (FSs) are a common pediatric condition caused by a sudden rise in temperature, affecting 3% to 5% of children aged ≤6 years. Although vaccination can cause FSs, little is known on whether FSs occurring in the time soon after vaccination (vaccine-proximate febrile seizures [VP-FSs] differ clinically from non-vaccine-proximate febrile seizures [NVP-FSs]). We compared the clinical profile and outcomes of VP-FS to NVP-FS. Read More

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http://dx.doi.org/10.1542/peds.2018-2120DOI Listing
April 2019
6 Reads

Impact of Etiology on Efficacy of Oral Triclofos in Recording Pediatric Electroencephalography: A Tertiary Care Center Study.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):234-237

Department of Neurology, Niloufer Children's Hospital, Hyderabad, Telangana, India.

Background And Objectives: Oral triclofos is a frequently used sedative in pediatric age to record sleep Electroencephalography (EEG). This study is aimed to assess efficacy, safety profile, need for second dose, and rescheduling of oral triclofos in relation to etiology.

Materials And Methods: This is a retrospective study done enrolling all children aged 6 months to 5 years referred for EEG over 1 year. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_280_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454965PMC

Febrile seizures with leukocytosis as a predictor for occult bacteremia.

Pediatr Int 2019 Apr 12. Epub 2019 Apr 12.

Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, JPN.

Background: Febrile children 3-36 months old, who had a body temperature > 39 °C and white blood cell count > 15,000/mm were known to be at risk for occult pneumococcal bacteremia (OPB) in the pre-pneumococcal conjugate vaccine (PCV) era. However, the positive predictive value of this criteria decreased dramatically after introduction of PCV, which indicates a need for alternative criteria. Previous studies demonstrated a high rate of febrile seizures in children with OPB, suggesting that screening may still be practical in this population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13862
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http://dx.doi.org/10.1111/ped.13862DOI Listing
April 2019
1 Read

Top studies relevant to primary care from 2018: From PEER.

Can Fam Physician 2019 Apr;65(4):260-263

Director of Programs and Practice Support for the College of Family Physicians of Canada and Professor in the Department of Family Medicine at the University of Alberta.

Objective: To summarize high-quality studies for 10 topics from 2018 that have strong relevance to primary care practice.

Quality Of Evidence: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching . Read More

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April 2019
2 Reads

SCN1A mutations in focal epilepsy with auditory features: widening the spectrum of GEFS plus.

Epileptic Disord 2019 Apr;21(2):185-191

Medical Genetics Unit, Sant'Orsola-Malpighi University Hospital, Bologna.

Epilepsy with auditory features (EAF) is a focal epilepsy syndrome characterized by prominent auditory ictal manifestations. Two main genes, LGI1 and RELN, have been implicated in EAF, but the genetic aetiology remains unknown in half of families and most sporadic cases. We previously described a pathogenic SCN1A missense variant (p. Read More

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http://dx.doi.org/10.1684/epd.2019.1046DOI Listing
April 2019
11 Reads

Epilepsy and seizures in young people with 22q11.2 deletion syndrome: Prevalence and links with other neurodevelopmental disorders.

Epilepsia 2019 Apr 11. Epub 2019 Apr 11.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.

Objective: The true prevalence of epileptic seizures and epilepsy in 22q11.2 deletion syndrome (22q11.2DS) is unknown, because previous studies have relied on historical medical record review. Read More

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http://dx.doi.org/10.1111/epi.14722DOI Listing
April 2019
1 Read

Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Cryptogenic temporal lobe epilepsy develops in the absence of identified brain injuries, infections, or structural malformations, and in these cases, an unidentified pre-existing abnormality may initiate febrile seizures, hippocampal sclerosis, and epilepsy. Although a role for GABAergic dysfunction in epilepsy is intuitively obvious, no causal relationship has been established. In this study, hippocampal GABA neurons were targeted for selective elimination to determine whether a focal hippocampal GABAergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14723
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http://dx.doi.org/10.1111/epi.14723DOI Listing
April 2019
8 Reads

Infection with HHV-6 and its role in epilepsy.

Epilepsy Res 2019 Mar 29;153:34-39. Epub 2019 Mar 29.

Center for Neuroscience, Children's National Medical Center, George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

Infection with Human Herpesvirus-6 (HHV-6) has been associated with different epilepsy syndromes, including febrile seizures and status epilepticus, acute symptomatic seizures secondary to encephalitis and temporal lobe epilepsy. This neurotropic DNA virus is ubiquitous and primary infection occurs in up to 80% of children by age two years. While two viral variants have been identified, HHV-6B is the one that has been primarily linked to disease in humans, including epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183062
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.016DOI Listing
March 2019
3 Reads

Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization.

Pediatr Emerg Care 2019 Apr 3. Epub 2019 Apr 3.

Objective: A brief resolved unexplained event (BRUE) in infancy is a common reason for visiting the emergency department. However, little is known about the long-term outcomes of such an event. This study evaluates future mortality, morbidity, and/or developmental outcome after a BRUE. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001816DOI Listing
April 2019
4 Reads

Association of Hypocapnia in Children with Febrile Seizures.

J Pediatr Neurosci 2018 Oct-Dec;13(4):388-391

Department of Paediatrics, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

Introduction: Febrile seizure is a benign condition in children. Susceptibility genes associated with febrile convulsions have been identified, but the precise pathophysiologic mechanism that triggers febrile seizure is unclear. Using animal models, it has been demonstrated that hyperthermia causes respiratory alkalosis with consequent brain alkalosis and seizures. Read More

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http://dx.doi.org/10.4103/JPN.JPN_73_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413613PMC
April 2019
3 Reads

Febrile Seizures: Risks, Evaluation, and Prognosis.

Am Fam Physician 2019 Apr;99(7):445-450

University of South Carolina Greenville School of Medicine, Greenville, SC, USA.

A febrile seizure is a seizure occurring in a child six months to five years of age that is accompanied by a fever (100.4°F or greater) without central nervous system infection. Febrile seizures are classified as simple or complex. Read More

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April 2019
2 Reads

Falling admissions to hospital with febrile seizures in the UK.

Arch Dis Child 2019 Mar 29. Epub 2019 Mar 29.

Department of Child Health, University of Aberdeen, Aberdeen, UK.

Objectives: There was a reduction in febrile seizure admissions in Scotland after 2008. Our hypothesis was that a similar trend would be seen in other countries.

Methods: We obtained the number of febrile and non-febrile seizure admissions in England and Scotland 2000-2013 and the incidence of all seizure admissions 2000-2013 in European countries. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316228DOI Listing
March 2019
1 Read

MEF2C-related epilepsy: Delineating the phenotypic spectrum from a novel mutation and literature review.

Seizure 2019 Mar 22. Epub 2019 Mar 22.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: MEF2C-related epilepsy has been poorly described in the literature, despite a consistent MEF2C haploinsufficiency phenotype characterized by severe language impairment and motor delay (MIM# 613443). We aimed to delineate the spectrum of electroclinical manifestations of MEF2C-related epilepsy from an illustrative case and literature review.

Methods: A retrospective chart review of our case was performed followed by a literature review on PubMed and OMIM. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.015DOI Listing
March 2019
2 Reads

Paramedic-Identified Enablers of and Barriers to Pediatric Seizure Management: A Multicenter, Qualitative Study.

Prehosp Emerg Care 2019 Mar 27:1-14. Epub 2019 Mar 27.

a Baylor College of Medicine, Department of Pediatrics, Section of Emergency Medicine , Texas Children's Hospital , 6621 Fannin Street , Houston , 77030 United States.

Background: Seizures have the potential to cause significant morbidity and mortality, and are a common reason EMS are requested for a child. An evidence-based guideline (EBG) for pediatric prehospital seizures was published and has been implemented as protocol in multiple EMS systems. Knowledge translation and protocol adherence in medicine can be incomplete. Read More

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http://dx.doi.org/10.1080/10903127.2019.1595234DOI Listing
March 2019
1 Read

Alzheimer's disease might depend on enabling pathogens which do not necessarily cross the blood-brain barrier.

Authors:
Janice Block

Med Hypotheses 2019 Apr 21;125:129-136. Epub 2019 Feb 21.

Health Center, Center for Integrative Medicine, Nachal Achziv 8/2, Beit Shemesh, Israel; Kupat Cholim Leumit, Sfat Emet 4, Beit Shemesh, Israel. Electronic address:

The development of Alzheimer's Disease (AD) might reflect, in its acquired aspects, a cooperative pathogenesis whereby infectious enablers which do not necessarily cross the blood-brain barrier augment the invasive properties of a less virulent organism, thus enabling it to infect the brain. An example interaction is described which involves Chlamydia species, Human papillomavirus (HPV), microbiota, and yeast, where yeast is a pathogen of low virulence which crosses the blood-brain barrier. The cooperative pathogenesis begins at the mucosal epithelium. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.044DOI Listing
April 2019
3 Reads

Hemiconvulsion-hemiplegia-epilepsy syndrome in Niger: A retrospective case series.

J Clin Neurosci 2019 Mar 16. Epub 2019 Mar 16.

Department of Medicine and Medical Specialties, Faculty of Medicine and Pharmacy, Abdou Moumouni University, Niamey, Niger.

Objective: To report the demographic, clinical and paraclinical characteristics as well as the outcomes during follow-up visits of HHE syndrome in Niger.

Patients And Methods: It was a retrospective study conducted at the Neurology Outpatient Clinic of the National Hospital of Niamey (Niger) between May 2003 and May 2018.

Results: During the period of study, 882 patients with epilepsy aged 20 years or less were seen in consultation among whom we collected 22 cases of HHE syndrome with a hospital prevalence of 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868193007
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http://dx.doi.org/10.1016/j.jocn.2019.03.008DOI Listing
March 2019
3 Reads

A case of Dravet Syndrome with a newly defined mutation in the SCN1A gene.

Turk Pediatri Ars 2018 Dec 1;53(4):259-262. Epub 2018 Dec 1.

Department of Pediatrics, Division of Pediatric Neurology, Ankara University School of Medicine, Ankara, Turkey.

Dravet syndrome is a catastrophic progressive epileptic syndrome. De novo loss of function mutations on the SCN1A gene coding voltage-gated sodium channels are responsible. Disruption of the triggering of hippocampal GABAergic interneurons is assumed as the cause of fall in the seizure threshold. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.4197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408181PMC
December 2018
3 Reads

Febrile seizures and related epileptic syndromes.

Authors:
Sema Saltık

Turk Pediatri Ars 2018 Dec 1;53(4):203-204. Epub 2018 Dec 1.

İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.86458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408195PMC
December 2018

Severe Factor X Deficiency Presenting as Febrile Seizure in an Infant.

J Pediatr Hematol Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Corneal Surgery and Ophthalmology, SK Soni Hospital, Jaipur, Rajasthan, India.

Factor X deficiency is a severe inherited coagulation disorder, which is characterized by severe systemic bleeding manifestations in affected individuals. It is a rare disorder with a frequency of around 1:1,000,000 in the general population. We present the case of an infant with factor X deficiency who presented with complex febrile seizure. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001453DOI Listing
March 2019
2 Reads

Early administration of vitamins B1 and B6 and l-carnitine prevents a second attack of acute encephalopathy with biphasic seizures and late reduced diffusion: A case control study.

Brain Dev 2019 Mar 9. Epub 2019 Mar 9.

Division of Neurology, National Center for Child Health and Development, Japan.

Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most prevalent encephalopathy in Japanese children. AESD is characterized by a prolonged febrile seizure on day 1 followed by secondary seizures and MRI abnormality on days 4-6, resulting in high incidence of neurological sequelae. We aimed to clarify whether early administration of vitamins (vitamin B1, vitamin B6, and l-carnitine) would improve the clinical course of AESD. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.02.015DOI Listing

G327E mutation in SCN9A gene causes idiopathic focal epilepsy with Rolandic spikes: a case report of twin sisters.

Neurol Sci 2019 Mar 4. Epub 2019 Mar 4.

Department of pediatrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Foshan, 528000, Guangdong, China.

The voltage-gated sodium channel NaV1.7, encoded by the gene SCN9A, is located in peripheral neurons and plays an important role in epileptogenesis. Previous studies have identified an increasing number of SCN9A mutations in patients with variable epilepsy phenotypes. Read More

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http://dx.doi.org/10.1007/s10072-019-03752-3DOI Listing
March 2019
8 Reads

In silico method for identification of novel copper and iron metabolism proteins in various neurodegenerative disorders.

Neurotoxicology 2019 Mar 1;73:50-57. Epub 2019 Mar 1.

Department of Biochemistry, AIIMS, Jodhpur, Rajasthan, India. Electronic address:

Copper (Cu) and Iron (Fe) has been the subject of intensive research over several decades as numerous seminal studies robustly support the involvement of Cu and Fe metabolism dyshomeostasis as a common denominator in several neurodegenerative disorders (particularly Alzheimer's disease and Parkinson's disease); however, till date, the exact "cause-effect" association has not been elucidated. Thus, there is urgent need to look for newer association/pathways of these redox active elements in different neuropathological conditions. Therefore, in this study, we have used bioinformatics based approach to identify novel Cu and Fe metabolism proteins in neurodegenerative disorders using Cytoscape software. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183048
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http://dx.doi.org/10.1016/j.neuro.2019.02.020DOI Listing
March 2019
11 Reads
3.379 Impact Factor

Can antipyretics reduce the risk of febrile seizures?

Authors:
Craig Mellis

J Paediatr Child Health 2019 Mar;55(3):373

University of Sydney, Sydney.

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http://doi.wiley.com/10.1111/jpc.14362
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http://dx.doi.org/10.1111/jpc.14362DOI Listing
March 2019
9 Reads

[Postvaccinal complications and management of suspected cases].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Apr;62(4):450-461

Paul-Ehrlich-Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Langen, Deutschland.

In all developed countries there is the possibility to protect oneself from vaccine-preventable diseases. However, not all individuals make use of this option. It is precisely in highly developed countries where a trend to vaccination hesitancy is noticeable, i. Read More

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http://dx.doi.org/10.1007/s00103-019-02913-1DOI Listing
April 2019
5 Reads

[A novel inherited STX1B mutation associated with generalized epilepsy with febrile seizures plus: a family analysis and literature review].

Zhonghua Er Ke Za Zhi 2019 Mar;57(3):206-210

Department of Pediatric Neurology, Guangzhou Women and Children's Medical Center, Guangzhou 510000, China.

To explore the clinical characteristics and treatment of a family with inherited generalized epilepsy with febrile seizures plus (GEFS+) caused by STX1B gene mutation and to review the literature. Clinical data of a child with GEFS+ and his family members who visited Guangzhou Women and Children Medical Center in August 2017 were collected. DNA samples of the proband and his parents, his grandparents were analyzed by the next-generation sequencing and confirmed by Sanger sequencing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.03.010DOI Listing
March 2019
5 Reads

Clinico-epidemiological Study of Viral Acute Encephalitis Syndrome Cases and Comparison to Nonviral Cases in Children from Eastern India.

J Glob Infect Dis 2019 Jan-Mar;11(1):7-12

Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Objectives: The objective is to study the clinico-epidemiological features of viral acute encephalitis syndrome (AES) cases and compare them with nonviral AES cases in children from Eastern India.

Methods: This prospective observational study was conducted in the department of pediatrics of a tertiary care teaching hospital in Eastern India over 18-month period. Children (6 months to 15 years) with acute onset of fever (≥37. Read More

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http://dx.doi.org/10.4103/jgid.jgid_26_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380098PMC
March 2019
12 Reads

Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Associated With Adenoviral Pneumonia.

Child Neurol Open 2019 5;6:2329048X19826288. Epub 2019 Feb 5.

Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Acute encephalopathy with biphasic seizures and late reduced diffusion is a subtype of acute encephalopathy described in a cohort of Japanese children. Few cases have been reported in countries other than Japan. It is characterized clinically by biphasic seizures and late reduced subcortical diffusion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1177/2329048X19826288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365989PMC
February 2019
1 Read

Incidence of hospitalisation for severe complications of influenza virus infection in Japanese patients between 2012 and 2016: a cross-sectional study using routinely collected administrative data.

BMJ Open 2019 Jan 17;9(1):e024687. Epub 2019 Jan 17.

Department of Health Sciences, University of Yamanashi, Chuo City, Japan.

Objective: To calculate the incidence of hospitalisation due to acute respiratory failure, pneumonia, acute respiratory distress syndrome (ARDS), febrile seizures and encephalitis/encephalopathy among influenza-positive patients in Japan, where point-of-care tests are routinely used to diagnose influenza.

Design: A cross-sectional study using routinely collected data.

Setting: Japanese clinics and hospitals between 2012 and 2016. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02468
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http://dx.doi.org/10.1136/bmjopen-2018-024687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340484PMC
January 2019
3 Reads

Hyperthermia-induced seizures followed by repetitive stress are associated with age-dependent changes in specific aspects of the mouse stress system.

J Neuroendocrinol 2019 Apr 20;31(4):e12697. Epub 2019 Mar 20.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.

Stress is among the most frequently self-reported factors provoking epileptic seizures in children and adults. It is still unclear, however, why some people display stress-sensitive seizures and others do not. Recently, we showed that young epilepsy patients with stress-sensitive seizures exhibit a dysregulated hypothalamic-pituitary-adrenal (HPA)-axis. Read More

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http://dx.doi.org/10.1111/jne.12697DOI Listing

Iron supplementation should be given in breath-holding spells regardless of anemia

Turk J Med Sci 2019 Feb 11;49(1):230-237. Epub 2019 Feb 11.

Background/aim: The purpose of this retrospective study was to determine the effectiveness of oral iron therapy in breath-holding spells and evaluation of electrocardiographical changes

Materials And Methods: Three hundred twelve children aged 1–48 months and diagnosed with breath-holding spells between January 2017 and April 2018 were included. Patients’ laboratory findings were compared with 100 patients who had one simple febrile seizure.

Results: Cyanotic breath-holding spells were diagnosed in 85. Read More

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http://dx.doi.org/10.3906/sag-1805-92DOI Listing
February 2019
1 Read

Melioidosis with a subdural collection - a case report.

BMC Infect Dis 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Medicine, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.

Background: Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions and abscesses, and can present with varied clinical manifestations. Melioidosis involving the central nervous system is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3782-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373098PMC
February 2019
1 Read

Clinical spectrum of -related epileptic disorders.

Neurology 2019 Mar 8;92(11):e1238-e1249. Epub 2019 Feb 8.

From the University of Tübingen (S. Wolking, J.M., Y.G.W., H.L., J.S.), Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Luxembourg Centre for Systems Biomedicine (P.M.), University of Luxembourg, Esch-sur-Alzette; Pediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G., C.M.), Children's Hospital Anna Meyer, University of Florence, Italy; Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Services (R.S.M.), University of Southern Denmark, Odense; Department of Clinical and Experimental Epilepsy (S.B.), UCL Institute of Neurology and Epilepsy Society, UK, London; Division of Neurology (K.L.H., I.H.), Children's Hospital of Philadelphia, PA; Department of Pediatric Neurology (C.D.A.), Centre de Compétences Maladies Rares, CHU Besançon; Service de Génétique (N.C.), Hospices Civils des Lyon, Bron; GENDEV Team (N.C.), Neurosciences Research Center of Lyon, Bron, France; Neuropediatric Clinic and Clinic for Neurorehabilitation (K.S.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Beaumont Hospital (P.W.-W.), Dublin, Ireland; Department of Pediatrics, Division of Medical Genetics, Institute of Human Genetics (B.A.M.), Departments of Neurology and Pediatrics (A.N.), and Departments of Neurology and Pediatrics, and Institute of Human Genetics (M.R.C.), University of California, San Francisco; Department of Neurology (W.V.P.), University Hospitals Leuven, Belgium; Department of Pediatrics (L.L.S.), Hvidovre Hospital, Denmark; King's College Hospital (S.O., E.H., S.G., D.K.P.), London; Evelina London Children's Hospital (S.O., E.H., S.G.), London, UK; Section of Genetics (K.B., M.S.S.), Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora; Clinique Bernoise Montana (T.D.), Crans-Montana, Switzerland; Department of Neuropediatrics (H.M.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics (A.T.P., S.J.L.K., J.C.T.) and Department of Oncology (D.V.V.), University of Oxford, UK; Epilepsy Center (M.P.C.), Health Sciences Department, San Paolo Hospital, University of Milan; Child Neuropsychiatry (F.D.), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Italy; Departments of Neurology and Clinical Genomics (R.H.G.) and Health Sciences Research and Clinical Genomics (E.W.K., C.K.), Mayo Clinic, Rochester, MN; Ambry Genetics (Z.P.), Aliso Viejo, CA; Department of Clinical Neuroscience (S.T.), King's College London; New Medicines (M.A., D.M.), UCB Pharma, Slough, UK; Neuropediatric Clinic and Clinic for Neurorehabilitation (G.J.K.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Research Institute for Rehabilitation, Transition and Palliation (G.J.K.), PMU Salzburg, Austria; Department of Neurology (D.H.L.), University of California, San Francisco; Neurogenetics Group (S. Weckhuysen), Center for Molecular Neurology, VIB, Antwerp; Laboratory of Neurogenetics (S. Weckhuysen), Institute Born-Bunge, University of Antwerp; Department of Neurology (S. Weckhuysen), Antwerp University Hospital, Antwerp, Belgium; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (D.K.P.), MRC Centre for Neurodevelopmental Disorders (D.K.P.), King's College London, UK; Evelina London Children's Hospital (D.K.P.), London, UK; Department of Neuropediatrics (I.H.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; Institute of Neuroscience (R.H.T.), Henry Wellcome Building, Newcastle University; Neurology Research Group (M.I.R.), Institute of Life Science, Swansea University Medical School, Swansea, UK; Service de Génétique (G.L.), Hospices Civils des Lyon, Bron; GENDEV Team (G.L.), Neurosciences Research Center of Lyon, Bron, France; NIHR University College London Hospitals Biomedical Research Centre (S.M.S.), UCL Institute of Neurology, London, UK; Cologne Center for Genomics (D.L.), University of Cologne, Germany; Stanley Center for Psychiatric Research (D.L.) and Program in Medical and Population Genetics (D.L.), Broad Institute of MIT and Harvard, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit (D.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.

Methods: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007089DOI Listing
March 2019
3 Reads

Systematic review finds that fever phobia is a worldwide issue among caregivers and healthcare providers.

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Aim: Fever phobia describes exaggerated concerns about the consequences of childhood fever and broader awareness is needed in everyday clinical practice. We investigated the factors associated with fever phobia in caregivers and healthcare providers and the geographical distribution of the issue.

Methods: The National Library of Medicine, Excerpta Medica and Google Scholar databases were searched. Read More

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http://dx.doi.org/10.1111/apa.14739DOI Listing
February 2019
5 Reads

Mutations in and in a patient with early-onset epileptic encephalopathy and respiratory depression.

Cold Spring Harb Mol Case Stud 2019 Feb 1;5(1). Epub 2019 Feb 1.

Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Early infantile epileptic encephalopathy (EIEE) is a severe disorder associated with epilepsy, developmental delay and intellectual disability, and in some cases premature mortality. We report the case of a female infant with EIEE and strikingly suppressed respiratory dysfunction that led to death. Postmortem research evaluation revealed hypoplasia of the arcuate nucleus of the medulla, a candidate region for respiratory regulation. Read More

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http://dx.doi.org/10.1101/mcs.a003442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371743PMC
February 2019
7 Reads

[Vaccination, febrile seizures and epilepsy].

Authors:
E D Belousova

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(10. Vyp. 2):67-71

Pirogov Russian National Research Medical University, Moscow, Russia.

This literature review addresses the risk of vaccination complications including neurological ones. Some vaccines associated with vaccine-induced febrile seizures (FS), e.g. Read More

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http://dx.doi.org/10.17116/jnevro201811810267DOI Listing
January 2018
4 Reads

Risk Factors of Recurrence of Febrile Seizures in Children in a Tertiary Care Hospital in Kanpur: A One Year Follow Up Study.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):31-36

Department of Pediatrics, GSVM Medical College, Kanpur, Uttar Pradesh, India.

Background: Febrile seizures are commonly seen in children and about one-third of the children develop a recurrence of febrile seizures.

Objectives: The main objective is to study the risk factors associated with recurrence of febrile seizures in Indian children.

Methods: This prospective, longitudinal study was carried out in the Department of Pediatrics, GSVM Medical College, Kanpur. Read More

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http://dx.doi.org/10.4103/aian.AIAN_472_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327698PMC
January 2019
2 Reads

Gene mutations in paediatric epilepsies cause NMDA-pathy, and phasic and tonic GABA-pathy.

Dev Med Child Neurol 2019 Jan 25. Epub 2019 Jan 25.

Inserm U1129, Infantile Epilepsies and Brain Plasticity, CEA Gif/Yvette, Pôle de Recherche et d'Enseignement Supérieur Sorbonne Paris Cité, Paris Descartes University, Paris, France.

The aim of this study was to disentangle mechanisms of epileptogenesis in monogenic epilepsies in children. We reviewed paediatric monogenic epilepsies excluding brain malformation or an inborn error of metabolism, but including the gene function whether there is loss-of-function or gain-of-function, age at gene expression when available, and associated epilepsy syndrome. Genes for which at least five patients with similar epilepsy phenotype had been reported were selected. Read More

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http://doi.wiley.com/10.1111/dmcn.14152
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http://dx.doi.org/10.1111/dmcn.14152DOI Listing
January 2019
10 Reads

Prolonged febrile seizures induce inheritable memory deficits in rats through DNA methylation.

CNS Neurosci Ther 2019 May 21;25(5):601-611. Epub 2019 Jan 21.

Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Aims: Febrile seizures (FSs) are the most common types of seizures in young children. However, little is known whether the memory deficits induced by early-life FSs could transmit across generations or not.

Methods: The memory functions of different generations of FS rats were behaviorally evaluated by morris water maze, inhibitory avoidance task, and contextual fear conditioning task. Read More

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http://doi.wiley.com/10.1111/cns.13088
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http://dx.doi.org/10.1111/cns.13088DOI Listing
May 2019
9 Reads

Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 02 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
5 Reads

Reduced cerebrospinal fluid levels of interleukin-10 in children with febrile seizures.

Seizure 2019 Feb 14;65:94-97. Epub 2019 Jan 14.

Pediatric Emergency Unit, Department of Pediatrics, Okmeydani Training and Research Hospital, Istanbul, Turkey.

Purpose: The exact etiology of febrile seizures (FS) is still unclear. However, it is thought that cytokine network activation may have a causative role. Therefore, this study aimed to evaluate the levels of interleukin-12 (IL-12) as a proinflammatory cytokine, interleukin-10 (IL-10) as an anti-inflammatory cytokine, and interferon-β (IFN-β), a marker of toll-like receptor-3 activation as a host response to viruses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183061
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http://dx.doi.org/10.1016/j.seizure.2019.01.008DOI Listing
February 2019
15 Reads

Novel ANKRD11 gene mutation in an individual with a mild phenotype of KBG syndrome associated to a GEFS+ phenotypic spectrum: a case report.

BMC Med Genet 2019 Jan 14;20(1):16. Epub 2019 Jan 14.

Department of Biomedical Science, University of Sassari, Sassari, Italy.

Background: KBG syndrome is a very rare autosomal dominant disorder, characterized by macrodontia, distinctive craniofacial findings, skeletal findings, post-natal short stature, and developmental delays, sometimes associated with seizures and EEG abnormalities. So far, there have been over 100 cases of KBG syndrome reported.

Case Presentation: Here, we describe two sisters of a non-consanguineous family, both presenting generalized epilepsy with febrile seizures (GEFS+), and one with a more complex phenotype associated with mild intellectual disability, skeletal and dental anomalies. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-019-0745-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332862PMC
January 2019
14 Reads