4,797 results match your criteria Febrile Seizures


Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University,, Department of Neurology and Neurosurgery, McGill University,, Research Institute of the McGill University Health Centre.

Hemiconvulsion-Hemiplegia-Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality. Read More

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http://dx.doi.org/10.1684/epd.2018.1017DOI Listing
December 2018

Childhood seizures and risk of psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study.

Lancet Child Adolesc Health 2018 Dec 6. Epub 2018 Dec 6.

National Center for Register-Based Research, Aarhus University, Aarhus, Denmark; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Background: Paediatric seizures have been linked to psychiatric disorders in childhood, but there is a paucity of large-scale population-based studies of psychiatric comorbidity in later life. We aimed to examine the relation between childhood seizures and the risk of psychiatric disorders in adolescence and early adulthood.

Methods: We did a register-based cohort study of all individuals born in Denmark in 1978-2002. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30351-1DOI Listing
December 2018

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department.

J Pediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the proportion of children presenting to the emergency department (ED) with altered mental status who demonstrate nonconvulsive seizures on reduced-lead electroencephalography (EEG), and to further investigate the characteristics, treatment, and outcomes in these patients compared with patients without nonconvulsive seizures.

Study Design: In this retrospective cohort study, we reviewed the database and medical records of pediatric patients (aged <18 years) in a single ED between May 1, 2016, and April 30, 2018. We first determined the proportion of nonconvulsive seizures among patients with altered mental status (Glasgow Coma Scale <15). Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.11.019DOI Listing
December 2018

Outcomes and comorbidities of SCN1A-related seizure disorders.

Epilepsy Behav 2018 Dec 4. Epub 2018 Dec 4.

Department of Genetics, University Medical Center Utrecht, Utrecht University, the Netherlands.

Purpose: Differentiating between Dravet syndrome and non-Dravet SCN1A-related phenotypes is important for prognosis regarding epilepsy severity, cognitive development, and comorbidities. When a child is diagnosed with genetic epilepsy with febrile seizures plus (GEFS+) or febrile seizures (FS), accurate prognostic information is essential as well, but detailed information on seizure course, seizure freedom, medication use, and comorbidities is lacking for this milder patient group. In this cross-sectional study, we explore disease characteristics in milder SCN1A-related phenotypes and the nature, occurrence, and relationships of SCN1A-related comorbidities in both patients with Dravet and non-Dravet syndromes. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.09.041DOI Listing
December 2018

New onset refractory status epilepticus (NORSE).

Seizure 2018 Sep 29. Epub 2018 Sep 29.

Département de Neurologie, Université Libre de Bruxelles, Hôpital Erasme, Brussels, Belgium; Comprehensive Epilepsy Center, Neurology Department, Yale University School of Medicine, New Haven, CT, USA.

Purpose: To summarize the clinical features, suggested work-up, treatment and prognosis of new-onset refractory status epilepticus (NORSE), a condition recently defined as the occurrence of refractory status epilepticus (RSE) in a patient without active epilepsy, and without a clear acute or active structural, toxic or metabolic cause; and of the related syndrome of febrile infection-related epilepsy syndrome (FIRES), also recently defined as a subgroup of NORSE preceded by a febrile illness between 2 weeks and 24 h prior to the onset of RSE.

Method: Narrative review of the medical literature about NORSE and FIRES.

Results: NORSE and FIRES mainly affect school-age children and young adults. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.018DOI Listing
September 2018
4 Reads

Similar relative risks of seizures following measles containing vaccination in children born preterm compared to full-term without previous seizures or seizure-related disorders.

Vaccine 2019 Jan 23;37(1):76-79. Epub 2018 Nov 23.

Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA.

Background: Febrile seizures are associated with the first dose of measles-containing vaccines and the risk increases with chronologic age during the second year of life. We used the Vaccine Safety Datalink (VSD) to determine if the relative increase in risk of seizures following receipt of measles-containing vaccine differs by gestational age at birth.

Methods: Children were eligible if they received their first dose of measles-containing vaccine at age 12 through 23 months from January 2003 through September 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183156
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http://dx.doi.org/10.1016/j.vaccine.2018.11.038DOI Listing
January 2019
5 Reads

Vaccines for Preventing Influenza in Healthy Individuals.

Authors:
Sally Liang

Acad Emerg Med 2018 Nov 21. Epub 2018 Nov 21.

Department of Emergency Medicine, SUNY Downstate Medical Center/Kings County Hospital Center (SL), Brooklyn, NY.

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http://dx.doi.org/10.1111/acem.13668DOI Listing
November 2018
4 Reads

Thermoregulation in epilepsy.

Handb Clin Neurol 2018 ;157:737-747

Departments of Neurological Sciences, Neurosurgery, Medicine, and Anesthesiology, Rush Medical College, Chicago, IL, United States; Clinical Neurophysiology Laboratory, Rush University Medical Center, Chicago, IL, United States.

Several aspects of thermoregulation play a role in epilepsy. Circuitries involved in thermoregulation are affected by seizures and epilepsy, hyperthermia may be both cause and result of seizures, and hypothermia may prevent or abort seizures. Autonomic manifestations of seizures including thermoregulatory disturbances are common in a variety of clinical epilepsy syndromes. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00045-8DOI Listing
January 2018
2 Reads

Diagnostics and treatment of children with acute seizures on paediatric intensive care unit.

Cas Lek Cesk 2018 ;157(3):130-132

218 children were admitted to paediatric clinic for acute seizures within last 5 years. Out of them, 14 children (7%) were admitted to paediatric intensive care unit (PICU) with repeated or prolonged seizures. Two children were hospitalized twice. Read More

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January 2018
1 Read

Electroencephalography in Pediatric Epilepsy.

Indian Pediatr 2018 Oct;55(10):893-901

Department of Pediatrics, BL Kapur Superspeciality Hospital, Delhi; India.

Surface electroencephalography (EEG) is a useful electrophysiological investigation for evaluating a paroxysmal event in children. It measures the electro potential difference between two points on the scalp. It is a non-invasive tool that analyzes neuronal maturation and abnormal cortical excitability. Read More

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October 2018
2 Reads

Neurologic Alterations Due to Respiratory Virus Infections.

Front Cell Neurosci 2018 26;12:386. Epub 2018 Oct 26.

Millennium Institute on Immunology and Immunotherapy (MIII), Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Central Nervous System (CNS) infections are one of the most critical problems in public health, as frequently patients exhibit neurologic sequelae. Usually, CNS pathologies are caused by known neurotropic viruses such as measles virus (MV), herpes virus and human immunodeficiency virus (HIV), among others. However, nowadays respiratory viruses have placed themselves as relevant agents responsible for CNS pathologies. Read More

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http://dx.doi.org/10.3389/fncel.2018.00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212673PMC
October 2018
1 Read

Adenovirus-Associated Central Nervous System Disease in Children.

J Pediatr 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

Objective: To characterize the spectrum and salient clinical features of adenovirus-associated neurologic disease in immunocompetent children.

Study Design: Previously healthy children (aged 1 month-18 years) with central nervous system (CNS) disease associated with adenovirus infection were identified via the Encephalitis Registry (1996-2016) and Microbiology Database (2000-2016) at The Hospital for Sick Children, Toronto, and by systematic review of the literature. The data were pooled and analyzed to identify the spectrum of illness, clinical outcome, and risk factors for death or neurologic impairment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183136
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http://dx.doi.org/10.1016/j.jpeds.2018.09.036DOI Listing
November 2018
7 Reads

Implementing Universal Varicella Vaccination in Europe: The Path Forward.

Pediatr Infect Dis J 2018 Nov 7. Epub 2018 Nov 7.

University of Tampere Medical School, Biokatu 10, 33014, Tampere, Finland.

Varicella is a common vaccine-preventable disease that usually presents as a mild disorder but can lead to severe complications. Before the implementation of universal varicella vaccination (UVV) in some European countries, the burden of varicella disease was broadly similar across the region. Despite this, countries adopted heterogeneous varicella vaccination strategies. Read More

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http://dx.doi.org/10.1097/INF.0000000000002233DOI Listing
November 2018
3 Reads

[Clinical characteristics and genetic features of benign infantile epilepsy with PRRT2 mutation].

Zhonghua Er Ke Za Zhi 2018 Nov;56(11):818-823

Department of Neurology, National Center for Children's Health (Beijing) , Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.

To summarize the detailed clinical characteristics and genetic features of benign infantile epilepsy with PRRT2 mutation, in order to improve the understanding of the disease. The clinical data and genetic results of 40 benign infantile epilepsy patients with PRRT2 mutation who were diagnosed and treated in the neurology department of National Center for Children's Health (Beijing) , Beijing Children's Hospital affiliated to Capital Medical University from January 2002 to October 2017 and their affected family members were analyzed. Forty benign infantile epilepsy patients were recruited for this study, with 18 males and 22 females. Read More

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November 2018
4 Reads

Myelin water fraction changes in febrile seizures.

Clin Neurol Neurosurg 2018 Dec 10;175:61-67. Epub 2018 Oct 10.

Division of Pediatric Neurosurgery, Joe DiMaggio Children's Hospital, 1150N 35th Ave, Hollywood, FL, 33021, USA. Electronic address:

Objective: The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.

Patients And Methods: As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences-T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)-and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183040
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http://dx.doi.org/10.1016/j.clineuro.2018.10.005DOI Listing
December 2018
3 Reads

Respiratory Syncytial Virus-Associated Seizures in Korean Children during 2011/01 -2016/12.

Korean J Pediatr 2018 Oct 23. Epub 2018 Oct 23.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, Republic of Korea.

Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that are presented with seizures.

Methods: We retrospectively reviewed the medical records of patients younger than 15 years who had laboratory-confirmed RSV infections and seizures from January 2011 to December 2016 in a regional hospital in South Korea. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.07066
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http://dx.doi.org/10.3345/kjp.2018.07066DOI Listing
October 2018
1 Read

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.

Brain 2018 Nov;141(11):3160-3178

EuroEPINOMICS RES Consortium.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segregating with epilepsy in 14 individuals, but not penetrant in six additional individuals. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy263DOI Listing
November 2018
11 Reads

Assessment of physicians knowledge and attitudes in the management of febrile seizures.

Neurosciences (Riyadh) 2018 Oct;23(4):314-319

Division of Neurology, Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail:

Objective: To assess the knowledge and attitudes of physicians in different specialties who are involved in the care of children with FS.

Methods: We assessed knowledge and attitudes in the management of Febrile seizure (FS) among physicians working in different specialties in the Kingdom of Saudi Arabia using a questionnaire-based cross-sectional study conducted from September-December 2016.

Results: Of the 300 physicians who responded to the questionnaire, 178 (59. Read More

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October 2018
8 Reads

Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study.

Front Neurol 2018 5;9:834. Epub 2018 Oct 5.

Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States.

One third of children with epilepsy are refractory to medications. Growing data support a role of common childhood infections with neurotropic viruses and inflammation in epileptogenesis. Our objective was to determine the frequency of Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) infection and cytokine levels in saliva from children with seizures compared to healthy controls and to controls with a febrile illness without seizures. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00834
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http://dx.doi.org/10.3389/fneur.2018.00834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182262PMC
October 2018
3 Reads

Association between Adverse Effects and Parental Beliefs about Antiepileptic Medicines.

Medicina (Kaunas) 2018 Aug 28;54(4). Epub 2018 Aug 28.

Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.

Adverse effects are common in children treated with antiepileptic medications and may affect parental beliefs about treatment. The aim of the study was to investigate the relationship between adverse effects and parental beliefs about antiepileptic drugs used for the treatment of their children. The study was performed at the University Children's Hospital, Belgrade, Serbia from 2013⁻2015. Read More

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http://dx.doi.org/10.3390/medicina54040060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174341PMC
August 2018
5 Reads

Seizures, Meds, and Vtach: A Journey to a Brugada Diagnosis.

Pediatr Emerg Care 2018 Oct 17. Epub 2018 Oct 17.

Arkansas College of Osteopathic Medicine, Fort Smith, AR.

Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001640DOI Listing
October 2018
6 Reads

Acute encephalopathy with biphasic seizures and late reduced diffusion accompanied by Takotsubo cardiomyopathy.

Brain Dev 2018 Oct 13. Epub 2018 Oct 13.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is characterized by biphasic seizures and impaired consciousness. Takotsubo cardiomyopathy (TTC), which is typically triggered by psychological or physical stress, is characterized by transient myocardial dysfunction affecting the left ventricular apex. Recent reports have suggested that seizures can also trigger TTC. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.10.002DOI Listing
October 2018
1 Read

Management of Pediatric Febrile Seizures.

Int J Environ Res Public Health 2018 10 12;15(10). Epub 2018 Oct 12.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza L. Severi 1, 06132 Perugia, Italy.

Febrile seizures (FS), events associated with a fever in the absence of an intracranial infection, hypoglycaemia, or an acute electrolyte imbalance, occur in children between six months and six years of age. FS are the most common type of convulsions in children. FS can be extremely frightening for parents, even if they are generally harmless for children, making it important to address parental anxiety in the most sensitive manner. Read More

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http://dx.doi.org/10.3390/ijerph15102232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210946PMC
October 2018
1 Read

The role of Mean Platelet Volume/platelet count Ratio and Neutrophil to Lymphocyte Ratio on the risk of Febrile Seizure.

Sci Rep 2018 Oct 11;8(1):15123. Epub 2018 Oct 11.

Department of pediatrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, 11 Renminxi Road, Foshan, Guangdong, 528000, China.

Systemic inflammatory response has been implicated as a contributor to the onset of febrile seizures (FS). The four novel indices of the inflammatory response such as, neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), platelet count (PLT) ratio and red blood cell distribution width (RDW) have been investigated in FS susceptibility and FS types (simple febrile seizure and complex febrile seizure). However, the potential role of these inflammatory markers and MPV/PLT ratio (MPR) in Chinese children with FS has yet to be fully determined. Read More

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http://www.nature.com/articles/s41598-018-33373-3
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http://dx.doi.org/10.1038/s41598-018-33373-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181908PMC
October 2018
2 Reads

Acetaminophen and Febrile Seizure Recurrences During the Same Fever Episode.

Pediatrics 2018 Nov 8;142(5). Epub 2018 Oct 8.

Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan.

Objectives: To confirm the safety of using acetaminophen for febrile seizures (FSs) and to assess its efficacy in preventing FS recurrence during the same fever episode.

Methods: In this single-center, prospective, open, randomized controlled study, we included children and infants (age range: 6-60 months) with FSs who visited our hospital between May 1, 2015, and April 30, 2017. The effectiveness of acetaminophen was examined by comparing the recurrence rates of patients in whom rectal acetaminophen (10 mg/kg) was administered every 6 hours until 24 hours after the first convulsion (if the fever remained >38. Read More

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http://dx.doi.org/10.1542/peds.2018-1009DOI Listing
November 2018
2 Reads

Fangjing decoction relieves febrile seizures-induced hippocampal neuron apoptosis in rats via regulating the Akt/mTOR pathway.

Biosci Rep 2018 Oct 31;38(5). Epub 2018 Oct 31.

Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou 310002, China.

: Fangjing decoction is a Traditional Chinese Medicine that exhibits anticonvulsive effects in treating febrile seizures (FS). Its action mechanism and the regulation on Akt/mammalian target of rapamycin (mTOR) pathway were revealed in the present study.: FS model was established in Sprague-Dawley rats with or without Fangjing decoction treatment. Read More

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http://dx.doi.org/10.1042/BSR20181206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209604PMC
October 2018

[Fatal spotted fever in Salta province].

Medicina (B Aires) 2018 ;78(5):356-359

Departamento de Medicina Interna y Terapia Intensiva, Hospital Papa Francisco, Salta, Argentina. E-mail:

We describe the case of a 17-year-old male patient living in Salta city who, 10 days after visiting a rural area in Salta province, was hospitalized for febrile seizures. Shortly after admission, he developed an exanthema followed by a multiple organ dysfunction that evolved to irreversible septic shock followed by death 48 hours after admission. Serological diagnosis -high IgM and IgG anti-Rickettsia spp. Read More

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January 2018
10 Reads

Cerebral Hydatid Cyst in a Young Immunocompromised Patient in Parakou.

J Neurosci Rural Pract 2018 Oct-Dec;9(4):622-624

Department of Neurology, Faculty of Medicine, University of Parakou, Parakou, Benin.

We report the case of a 30-year-old human immunodeficiency virus (HIV)-positive HIV patient who was poorly followed. She was admitted on November 30, 2017, for the management of febrile encephalitis syndrome with motor deficit of the left hemicorps and generalized seizures. In biology, we found a nonspecific inflammatory syndrome. Read More

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http://www.ruralneuropractice.com/text.asp?2018/9/4/622/2398
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http://dx.doi.org/10.4103/jnrp.jnrp_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126280PMC
October 2018
1 Read

Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

Epilepsia 2018 Nov 6;59(11):2005-2018. Epub 2018 Sep 6.

Department of Anatomy/Neurobiology, University of California, Irvine, Irvine, California.

Objective: A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those at risk that can be identified soon after FSE, within a clinically realistic timeframe.

Methods: Longitudinal T -weighted magnetic resonance imaging (T WI MRI) of rat pups at several time points after experimental FSE (eFSE) was performed on a high-field scanner followed by long-term continuous electroencephalography. Read More

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http://dx.doi.org/10.1111/epi.14561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217797PMC
November 2018
4 Reads

Prognosis of Juvenile myoclonic epilepsy with eye-closure sensitivity.

Seizure 2018 Nov 17;62:17-25. Epub 2018 Sep 17.

Unidade de Pesquisa e Tratamento das Epilepsias, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. Electronic address:

Purpose: Eye closure sensitivity (ECS) has been described as a reflex trait in juvenile myoclonic epilepsy (JME). However, there is no consensus regarding its significance on prognosis. The aim of this study is to clarify the long-term impact of ECS documented by a clinical interview and a video-EEG neuropsychological protocol (VNPP) in a series of 133 JME patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.09.006DOI Listing
November 2018
5 Reads

Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups.

J Clin Virol 2018 Nov 8;108:43-49. Epub 2018 Sep 8.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, China; Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Background: Coxsackievirus A6 (CV-A6) represents the predominant enterovirus serotype in Hong Kong, but its epidemiology in our population was unknown.

Objectives: To examine the clinical and molecular epidemiology of CV-A6 and detect emerging recombinant strains in Hong Kong.

Study Design: Nasopharyngeal aspirates (NPAs) from patients with febrile or respiratory illness were subject to RT-PCR for CV-A6 and sequencing of 5'-NCR and VP1. Read More

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http://dx.doi.org/10.1016/j.jcv.2018.09.002DOI Listing
November 2018
2 Reads

Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study).

Hum Vaccin Immunother 2018 Sep 20:1-7. Epub 2018 Sep 20.

p Faculty of Medicine, Department of Pediatrics , Eskisehir Osmangazi University , Eskisehir , Turkey.

Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Read More

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http://dx.doi.org/10.1080/21645515.2018.1526588DOI Listing
September 2018
4 Reads

National registry of patients with Fukuyama congenital muscular dystrophy in Japan.

Neuromuscul Disord 2018 Oct 10;28(10):885-893. Epub 2018 Aug 10.

Department of Pediatrics, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; The Japan Muscular Dystrophy Association, Tokyo, Japan.

Fukuyama congenital muscular dystrophy (FCMD) is the second most common form of muscular dystrophy in the Japanese population and is caused by mutations in the fukutin (FKTN) gene. In 2011, the Japan Muscular Dystrophy Association (JMDA) developed a nationwide registry of genetically confirmed patients with FCMD. We retrospectively reviewed the registry dataset of patients with FCMD to obtain data, including age, sex, developmental milestones, intellectual level, complications, and primary treatments. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.08.001DOI Listing
October 2018
1 Read
2.640 Impact Factor

Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis.

Epidemiol Infect 2018 Sep 13:1-6. Epub 2018 Sep 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,Singapore,Singapore.

Febrile seizure (FS) in children is a common complication of infections with respiratory viruses and hand, foot and mouth disease (HFMD). We conducted a retrospective ecological time-series analysis to determine the temporal relationship between hospital attendances for FS and HFMD or respiratory virus infections. Epilepsy attendance was used as a control. Read More

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http://dx.doi.org/10.1017/S0950268818002509DOI Listing
September 2018
7 Reads

Ptosis in childhood: A clinical sign of several disorders: Case series reports and literature review.

Medicine (Baltimore) 2018 Sep;97(36):e12124

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Blepharoptosis (ptosis) is a common but often overlooked sign that may serve as a sign/manifestation of other conditions, ranging from a mild and purely cosmetic presentation to a severe and occasionally progressive disorder. Ptosis may show an acute onset or may manifest as a chronic disorder. Its presentation may vary: unilateral versus bilateral, progressive versus non-progressive, isolated versus complex which occurs in association with other symptoms, and congenital versus acquired (often concomitant with neuromuscular disorders). Read More

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http://dx.doi.org/10.1097/MD.0000000000012124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133583PMC
September 2018
1 Read

[Febrile seizures: questions and answers].

Medicina (B Aires) 2018 ;78 Suppl 2:18-24

Cátedra de Neuropediatría, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

A febrile seizure occurs in association with fever in a child aged 6 to 60 months, without central nervous system infection or other known cause of acute seizures in a child without a prior history of afebrile seizures. Febrile seizures occur in about 2-5% of children. Central nervous system infections should be considered in patients with febrile seizures, even though the frequency of this possibility is low, especially when patients do not return to baseline. Read More

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January 2018
8 Reads

[Evaluation of a child with a first unprovoked seizure].

Medicina (B Aires) 2018 ;78 Suppl 2:6-11

Unidad de Epilepsia, Sección de Neuropediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España. E-mail:

Paroxysmal episodes are one of the most common neurological disorders in children. It is important to distinguish between paroxysmal non-epileptic events, symptomatic seizures, febrile seizures, and unprovoked seizures. Patient's history is the key to proper diagnosis in most of the cases. Read More

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January 2018

Risk of low serum levels of ionized magnesium in children with febrile seizure.

BMC Pediatr 2018 Sep 7;18(1):297. Epub 2018 Sep 7.

Department of Pediatrics, Korea University College of Medicine, Seoul, South Korea.

Background: Suboptimal intake of magnesium become prevalent due to the modern diet of processed food low in magnesium. Magnesium may modulate seizure activity by antagonizing excitatory calcium influx through the N-methyl-D-aspartate receptor. Although hyponatremia has been reported to be common in febrile seizures, the most common form of seizure, little is known about the status of serum ionized magnesium. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-018-1271-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128998PMC
September 2018
10 Reads

First-ever convulsive seizures in children presenting to the emergency department: risk factors for seizure recurrence and diagnosis of epilepsy.

Dev Med Child Neurol 2019 Jan 7;61(1):82-90. Epub 2018 Sep 7.

Emergency Department, Department of Women's and Children's Health, University of Padua, Padua, Italy.

Aim: Aetiologies of first-ever convulsive seizures may be diverse, not all leading to recurrence or epilepsy diagnosis. We aimed to describe the epidemiology of first-ever convulsive seizures in children, investigating risk factors for recurrence and epilepsy diagnosis.

Method: This was a retrospective study of children presenting with a first-ever convulsive seizure to a tertiary-care paediatric emergency department (PED) in Italy, in a 12-month period (2011-2012). Read More

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http://dx.doi.org/10.1111/dmcn.14015DOI Listing
January 2019

Optimal Doses of H1 Antihistamines Do Not Increase Susceptibility to Febrile Convulsions in Children.

Pediatr Neurol 2018 Oct 18;87:42-47. Epub 2018 May 18.

Department of Pediatrics, National Hospital Organization Beppu Medical Center, Oita, Japan. Electronic address:

Background: The purpose of this study was to elucidate whether H1 antihistamine administration increases susceptibility to febrile convulsions in children.

Methods: A single-center, retrospective observational study was conducted in Japan. The study included 380 children with febrile convulsions between the ages of six months and five years transported via ambulance from 2011 through 2016. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.04.013DOI Listing
October 2018
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Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study.

Seizure 2018 Oct 27;61:164-169. Epub 2018 Aug 27.

Children's Hospital, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Purpose: Trends of epilepsy in children were correlated with febrile seizure (FS) in a previous retrospective study. In the present study, the authors obtained relevant data from a nationwide cohort database to investigate trends in subsequent epilepsy in children with a history of recurrent FS.

Methods: A total of 10,210 children with FS comprised the cohort. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.019DOI Listing
October 2018
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Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study.

Lancet Child Adolesc Health 2018 Feb 6;2(2):103-111. Epub 2017 Dec 6.

Clinical Neurosciences, UCL Great Ormond Street Institute of Child Health, London, UK; Muir Maxwell Epilepsy Centre, Department of Child Life and Health, The University of Edinburgh, Edinburgh, UK.

Background: The prognosis of convulsive status epilepticus (CSE), a common childhood medical neurological emergency, is not well characterised. We aimed to investigate the long-term outcomes in a cohort of participants who previously had CSE.

Methods: In this prospective study, we followed up a population-based childhood CSE cohort from north London, UK (the north London convulsive status epilepticus surveillance study cohort; NLSTEPSS). Read More

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http://dx.doi.org/10.1016/S2352-4642(17)30174-8DOI Listing
February 2018
9 Reads

National survey of factors associated with repeated admissions due to febrile seizure.

Seizure 2018 Oct 13;61:149-152. Epub 2018 Aug 13.

Division of Pediatric Neurology, Department of Pediatrics, UCLA Medical Center, LA, CA, USA.

Purpose: Several studies reported recent trends in febrile seizure (FS) in terms of prevalence, incidence, and hospitalization rates at a national level in the USA. However, no studies have revealed risk factors for repeated admissions due to FS.

Method: We extracted discharge records of patients with FS aged < 6 years for the years 2010-14 using the Nationwide Readmission. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.013DOI Listing
October 2018
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Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus.

Brain Dev 2018 Nov 23;40(10):884-890. Epub 2018 Aug 23.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Fosphenytoin (fPHT) and continuous intravenous midazolam (cMDL) had commonly been used as second-line treatments for pediatric status epilepticus (SE) in Japan. However, there is no comparative study of these two treatments.

Methods: We included consecutive children who 1) were admitted to Kobe Children's Hospital because of convulsion with fever and 2) were treated with either fPHT or cMDL as second-line treatment for convulsive SE lasting for longer than 30 min. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183039
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http://dx.doi.org/10.1016/j.braindev.2018.08.001DOI Listing
November 2018
16 Reads

Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats.

Neurobiol Dis 2018 Nov 16;119:172-189. Epub 2018 Aug 16.

Alberta Children's Hospital Research Institute, Department of Pediatrics, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. Electronic address:

Thermal hyperpnea, a pattern of breathing during hyperthermia that is characterized by an increase in tidal volume as well as breathing frequency, is known to lead to respiratory alkalosis. Thermal hyperpnea-induced respiratory alkalosis is linked to febrile seizures (FS). The heat-sensitive transient receptor potential vanilloid-1 (TRPV1) receptors are localized in, and implicated in the heat sensitivity of peripheral and central structures involved in the respiratory response to hyperthermia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183041
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http://dx.doi.org/10.1016/j.nbd.2018.08.004DOI Listing
November 2018
8 Reads

Mesial Temporal Sclerosis in SCN1A-Related Epilepsy: Two Long-Term EEG Case Studies.

Clin EEG Neurosci 2018 Aug 17:1550059418794347. Epub 2018 Aug 17.

1 Department of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr von Haunersches Children's Hospital, University of Munich, Munich, Germany.

Patients with temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) are eligible candidates for resective epilepsy surgery. We report on 2 male patients aged 4 years with suspected TLE due to MTS who were referred for presurgical evaluation. Both patients came to medical attention within the first year of life suffering from febrile status epileptici and subsequent unprovoked seizures. Read More

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http://journals.sagepub.com/doi/10.1177/1550059418794347
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http://dx.doi.org/10.1177/1550059418794347DOI Listing
August 2018
18 Reads

Acute Leukoencephalopathy with Restricted Diffusion.

Authors:
Mahesh Kamate

Indian J Crit Care Med 2018 Jul;22(7):519-523

Department of Pediatrics, JN Medical College, KLE University, Belgaum, Karnataka, India.

Treatment and outcome of children with acute encephalopathy depend on the cause, prompt treatment of the underlying cause, and use of adequate supportive measures. Many novel causes of acute encephalopathy are emerging where lumbar puncture, computed tomography of the head, and routine biochemical testing can be normal such as acute disseminated encephalomyelitis and febrile infection-related refractory epilepsy syndrome. Magnetic resonance imaging (MRI) plays an important role in the workup of children with acute leukoencephalopathy. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069315PMC
July 2018
2 Reads

Inhibition of DPP4 enhances inhibitory synaptic transmission through activating the GLP-1/GLP-1R signaling pathway in a rat model of febrile seizures.

Biochem Pharmacol 2018 Oct 4;156:78-85. Epub 2018 Aug 4.

Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, China.

Dipeptidyl peptidase-IV (DPP4) is a cell surface serine peptidase widely expressed in the brain. Recent studies suggest that DPP4 contributes to the development of febrile seizures (FS); however, the underlying mechanism is still unclear. Thus, we investigated the role of DPP4 in the progression of FS at the molecular and electrophysiological levels using FS models in vivo and in vitro. Read More

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http://dx.doi.org/10.1016/j.bcp.2018.08.004DOI Listing
October 2018
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Sociodemographic risk factors for febrile seizures: A school-based study from Izmir, Turkey.

Seizure 2018 Oct 25;61:45-49. Epub 2018 Jul 25.

Dokuz Eylül University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, İzmir, Turkey.

Purpose: Despite the fact that socioeconomic and environmental factors of a population are changing over time, there are few studies focusing on the effects of sociodemographic factors on the prevalence of febrile seizures (FS). This study was designed to find out the prevalence of FS and to investigate the effect of socio-cultural and economic factors on this prevalence among the Turkish school children.

Methods: A school-based, cross-sectional study was conducted in first and second-class children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183020
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http://dx.doi.org/10.1016/j.seizure.2018.07.019DOI Listing
October 2018
8 Reads