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Acta Derm Venereol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Venereology and Allergy, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, DE-68167 Mannheim, Germany.

J Drugs Dermatol 2019 Jan;18(1):92-102

wide variety of therapeutic options, some challenges have arisen: designing an adequate treatment plan, electing the most suitable procedures for the patient, taking into consideration the rheological characteristics of the products, considering the amount needed to achieve a natural look, but also defining the safest way to deliver the treatment. Aging of the facial structural tissue layers occurs at a different pace and the requirements for the aesthetic approach of a 30-year-old patient are different from a 60-year-old patient. A group of twelve experts in minimally invasive injectable procedures sought to identify common changes observed in different age groups in order to help in establishing a plan of treatment for patients of different ages. Read More

J Drugs Dermatol 2019 Jan;18(1):86-91

Background: Calcium hydroxylapatite (CaHA, Radiesse®) with integral 0.3% lidocaine (CaHA(+)) has recently been approved for use in aesthetic medicine. This study assessed the performance of CaHA(+) in subjects undergoing treatment for facial volume loss and evaluated subject and physician satisfaction. Read More

J Drugs Dermatol 2019 Jan;18(1):80-85

Introduction: The skin of subjects with dry, flaking, and/or scaling conditions is characterized by decreased water and skin lipids content among other findings. It is well understood that daily use of gentle cleansers and moisturizers may help to restore and maintain an optimal skin barrier function. A cohort study of patients with dry skin was developed to evaluate efficacy of daily use of a ceramide containing cleanser and cream that also has salicylic acid. Read More

J Drugs Dermatol 2019 Jan;18(1):75-79

Background: A device that uses microfocused ultrasound with visualization (MFU-V) is cleared in the United States and European Union as a noninvasive procedure that lifts and tightens the skin (Ultherapy® System; Merz North America, Raleigh, NC, USA). The objective of this patient survey was to obtain more in-depth information on patient satisfaction during the MFU-V treatment procedure and satisfaction with their aesthetic results. Methods: Survey participants had received MFU-V treatment and completed at least 6 months of follow-up. Read More

J Drugs Dermatol 2019 Jan;18(1):67-74

Objective: To study the safety, efficacy, optimal volume, and longevity of an injectable hyaluronic acid (HA) gel dermal filler to treat facial temporal fossa fat loss. Methods and materials: This open-label, single-site, 12-month study used 20 mg/mL HA gel to correct volume loss in both temples in 30 subjects. Touch-ups were allowed at week 2. Read More

J Drugs Dermatol 2019 Jan;18(1):59-64

Background: The safety and effectiveness of high-intensity precision radiofrequency (RF) for rejuvenating the aging neck and face, and of fractional laser therapy for treating photodamaged skin have each been previously demonstrated. Objective: To assess the effects of combining high-intensity precision RF and fractional laser therapy for treating the aging face and neck. Methods and Materials: Subjects (N=19) with Fitzpatrick skin types I to VI and mild-to-moderate solar elastosis and sun or age-related pigmentation on the face and/or neck were sequentially treated with high-intensity precision RF and fractionated laser devices during the same session. Read More

J Drugs Dermatol 2019 Jan;18(1):40-48

Perceptions of attractiveness can be negatively affected by submental fullness. Patients seeking to improve their submental contour have a variety of treatment options including surgical procedures, energy-based devices, and injectable treatment. The Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR) was designed to provide insights into the treatment of submental fat (SMF) in clinical practice. Read More

J Drugs Dermatol 2019 Jan;18(1):32-38

Background: Acne vulgaris (acne) is the most common dermatologic disease seen in a racially, geographically, politically, culturally, and socioeconomically diverse Hispanic population. Despite their growing demographics in the US, there are few studies evaluating acne treatment in this population. Potential for skin irritation and dryness, as well as pigmentary changes are key concerns. Read More

J Drugs Dermatol 2019 Jan;18(1):28-31

Background: Moisturizers create the illusion of smooth, soft skin by placing a temporary film over the skin surface or by imparting a transient hydration benefit that does not clinically improve the quality or appearance of skin. Objective: The objective of this 8-week study was to assess the clinically relevant effects of a 3-step facial treatment program to improve the multiple qualities of photoaged skin. Methods: Thirty-five female subjects were evaluated at baseline and after 2, 4, and 8 weeks. Read More

J Drugs Dermatol 2018 Dec;17(12):s51-55

Acne vulgaris is the most common skin condition affecting adolescents and young adults with a tremendous psychosocial impact. Its pathogenic hallmarks include follicular dyskeratosis, increased sebum production, and inflammation induced by Cutibacterium (formerly Propionibacterium) acnes within the follicle. Retinoids, derived from vitamin A, are the mainstays of acne treatment given they address the key pathogenic pathways of acne. Read More

J Drugs Dermatol 2018 Dec;17(12):s44-48

Acne is a common disease affecting a high percentage of the younger population. Without appropriate and effective primary prevention of scarring, post-acne scars occur in about 80-95% of all patients. Acne scarring is the result of an alteration of the healing process and it can have deep psychosocial implications for patients. Read More

J Drugs Dermatol 2018 Dec;17(12):s43

This supplement summarize recent advances in the scientific understanding of acne pathogenesis as it relates to effective treatment acne in patients of all skin types and describes the role of retinoids in the management of acne and effective treatment and prevention strategies for hypertrophic and atrophic acne scarring in all skin types. Read More

J Drugs Dermatol 2018 Dec;17(12):1310-1315

Objective: To evaluate the safety and efficacy of ISDINCEUTICS Melaclear® serum (Barcelona, Spain) on skin brightness, skin quality, and signs of facial aging. Design: This was a single-center, observational, open label, prospective clinical study. Ten healthy females (ages 30-70) with moderate signs of facial aging and moderate photodamage (hyperpigmentation and/or sun spots) were enrolled. Read More

Pan Afr Med J 2018 26;30:226. Epub 2018 Jul 26.

Department of Dermatology and Venereology, Ibn Rochd University Hospital, Casablanca, Morocco.

Morbihan disease (MD) is a rare entity. Its nosography is unclear and its therapeutic management is difficult. We report a new case of MD. Read More

Pediatr Dermatol 2019 Jan 11;36(1):e20-e22. Epub 2018 Dec 11.

Department of Dermatology, Children's of Alabama, Birmingham, Alabama.

Dermatophyte infections are exceedingly rare in neonates, possibly due to the thin stratum corneum and high sebum content of neonatal skin. Only a handful of cases of tinea faciei have been reported in neonates, with the majority of reports occuring in India. Here, we report what to our knowledge is the earliest reported presentation of tinea faciei in the United States. Read More

Br J Dermatol 2018 Nov 30. Epub 2018 Nov 30.

Allergan plc, Irvine, CA.

Background: Once-daily topical oxymetazoline cream 1.0% significantly reduced persistent facial erythema of rosacea in trials requiring live, static patient assessments.

Objective: To critically evaluate the methodology of clinical trials that require live, static patient assessments by determining whether assessment of erythema is different when reference to the baseline photograph is allowed. Read More

J Drugs Dermatol 2018 Nov;17(11):1169 - 1172

INTRODUCTION: It has been well established that patients with darker skin types (Fitzpatrick skin types IV-VI) have an increased incidence of thermal induced side effects from laser and radio frequency (RF) treatments. Complications include a higher risk of post-inflammatory hyperpigmentation, hypopigmentation, and scarring, leading to unsatisfactory clinical outcomes. Fractional technologies improve the safety when treating patients with skin of color by treating only fractions of the skin while leaving a healing reservoir of untreated skin that improves the healing process. Read More

J Drugs Dermatol 2018 Nov;17(11):1164 - 1168

BACKGROUND: Laser skin resurfacing has continued to evolve over the past two decades. One of the most recent advances included a hybrid fractional laser resurfacing system that can sequentially utilize two wavelengths in its delivery, non-ablative coagulation with 1470 nm, and ablative vaporization with 2940 nm. The 1470 nm laser wavelength is absorbed by water, which is ideal for creating controlled zones of coagulation to chosen depths into the dermis up to 700 micrometers. Read More

J Drugs Dermatol 2018 Nov;17(11):1157 - 1162

OBJECTIVE: The aim of this study was to evaluate the incidence of adverse effects following laser skin resurfacing with the microablative carbon dioxide (CO2) laser system (SmartXide DOT; DEKA, Calenzano, Italy). METHODS: A retrospective chart review was performed. Data was collected for DOT laser procedures performed at three clinical centers from 2008-2014. Read More

Front Pharmacol 2018 2;9:1254. Epub 2018 Nov 2.

Department of Biomedical Sciences and Engineering, National Central University, Taoyuan City, Taiwan.

Acne vulgaris, generally resulted from overgrowth of (), is one of the most difficult-to-treat facial dermatoses and more than 90% of adolescents experienced the disease worldwide. Because the innate non-lymphoid immune system cannot effectively eliminate excessive from the skin surface, so far the therapy of acne vulgaris is still mainly dependent on antibiotic treatment. However, long-term or overdose of antibiotics may initiate microbial drug resistance and/or generate unexpected side effects that seriously hamper the use of antibiotics in the clinic. Read More

Presse Med 2018 Nov - Dec;47(11-12 Pt 1):1035-1037. Epub 2018 Oct 29.

CHU Ibn Rochd, service de dermatologie vénérologie, Casablanca, Maroc.

Am J Dermatopathol 2018 Nov;40(11):857-858

Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

J Cosmet Dermatol 2018 Oct 5;17(5):770-774. Epub 2018 Oct 5.

Skin Laser & Surgical Specialists of NY and NJ, Hackensack, New Jersey.

Objective: To evaluate the efficacy and safety associated with use of a 589-nm solid-state laser for treatment of facial erythema.

Methods: A prospective, IRB-approved study was conducted. Participants who were interested in treatment for facial erythema were recruited. Read More

J Drugs Dermatol 2018 Sep;17(9):1018

I read with interest the informative article by Spencer et al1 that describes the efficacious use as a novel skin lightening agent (LumaPro-C) for the treatment of patients with melasma. Read More

J Drugs Dermatol 2018 Sep;17(9):1015

When rejuvenating the face with soft tissue fillers, one must consider its structural framework, and patient specific goals/needs holistically to achieve natural results. Read More

J Drugs Dermatol 2018 Sep;17(9):1006-1009

Introduction: The evaluation of Acne using ordinal scales reflects the clinical perception of severity but has shown low reproducibility both intra- and inter-rater. In this study, we investigated if Artificial Intelligence trained on images of Acne patients could perform acne grading with high accuracy and reliabilities superior to those of expert physicians.

Methods: 479 patients with acne grading ranging from clear to severe and sampled from three ethnic groups participated in this study. Read More

J Drugs Dermatol 2018 Sep;17(9):987-996

Background: Side effects may limit the use of current tetracycline-class antibiotics for acne.

Objective: Evaluate the efficacy and safety of once-daily sarecycline, a novel, narrow-spectrum tetracycline-class antibiotic, in moderate to severe acne.

Methods: Patients 9-45 years with moderate to severe facial acne (Investigator's Global Assessment [IGA] score ≥ 3, 20-50 inflammatory and ≤ 100 noninflammatory lesions, and ≤ 2 nodules) were randomized 1:1 to sarecycline 1. Read More

J Drugs Dermatol 2018 Sep;17(9):975-981

Introduction: Air pollution continues to be a global health concern and recent studies have shown that air pollutants can cause skin damage and skin aging through several pathways that induce oxidative stress, inflammation, apoptosis, and skin barrier dysfunction. Preventive measures need to be considered to retain optimal skin health, and topical skincare products may be able to alleviate the negative effects of air pollution on skin. A randomized, double-blind, placebo-controlled clinical usage study was conducted to assess the efficacy and tolerability of a novel two-part skincare system (LVS) that was developed to provide protection against environmental skin aggressors including air pollution. Read More

J Drugs Dermatol 2018 Sep;17(9):970-973

Introduction: Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent, moisturizer, and an aid for wound healing. In this study, we explore the efficacy of topical EGF in the treatment of melasma. Read More

Am J Dermatopathol 2018 Oct;40(10):778-779

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Facial Plast Surg Clin North Am 2018 Nov 16;26(4):447-454. Epub 2018 Aug 16.

Private Practice, 1701 East Prospect Road, Fort Collins, CO 80525, USA. Electronic address:

Microneedling is a popular and cost-effective treatment with little down time. The application of topical agents to enhance outcomes is common practice. Microchannels created with nonthermal needling close at 4 hours to 6 hours due to fibrin plugs. Read More

Indian J Dermatol 2018 Sep-Oct;63(5):375-379

Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.

Background: Awareness against abuse of topical corticosteroids (TC), especially over the face, has been going on for last 5 years in India. In spite of that we are getting lots of cases in our hospitals.

Aims: The aims of this study were to ascertain the demographics, magnitude and clinical features of TC misuse on the face among the dermatology outpatient department (OPD) attendees and to analyze its causes. Read More

Respir Care 2018 Sep;63(9):1102-1110

Southampton General Hospital, Clinical Academic Facility, Faculty of Health Sciences, University of Southampton, Southampton, United Kingdom.

Background: The use of noninvasive ventilation masks is known to cause damage to facial skin tissue, which affects both the efficacy of the intervention and the patient's quality of life. The use of humidification with noninvasive ventilation is a common practice, but its relative role in the development of facial pressure ulcers has not been fully studied.

Methods: A crossover cohort design was used in this study, with 15 healthy volunteers. Read More

Pediatr Dermatol 2018 Nov 28;35(6):748-753. Epub 2018 Aug 28.

Division of Dermatology, Department of Medicine, University of Arizona, Tucson, Arizona.

Head-and-neck dermatitis is a variant of atopic dermatitis (AD) often seen in children and is challenging to diagnose, as it frequently overlaps with other eczematous dermatoses. Successful head-and-neck dermatitis (HND) treatment requires identification of common triggers and clinical mimickers, such as airborne dermatitis, periorificial dermatitis, and steroid-induced rosacea. Head-and-neck involvement negatively impacts quality of life and is often harder to treat than other body parts, as long-term topical corticosteroid use carries higher risks for skin atrophy on the face. Read More

Am J Dermatopathol 2018 Nov;40(11):819-823

Dermatology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Granulomatous rosacea (GR) and lupus miliaris disseminatus faciei (LMDF) are 2 forms of facial granulomatous diseases. Although they show some morphological overlap, they have distinct clinical presentation. This study was performed to demonstrate the clinical and histological features of GR and LMDF and to establish their relationship to tuberculous etiology by molecular technique. Read More

An Bras Dermatol 2018 Jul-Aug;93(4):605-607

Ambulatório de Dermatologia Sanitária de Porto Alegre, Porto Alegre (RS), Brazil.

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis, with variable clinical features, nonspecific histopathology and multifactorial pathogenesis, posing a challenging diagnosis for the dermatologist. Pyoderma gangrenosum is a diagnosis of exclusion and should be included in the differential diagnoses of the verrucous syndrome. We report a granulomatous variant affecting the face. Read More

An Bras Dermatol 2018 Jul-Aug;93(4):587-589

Service of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo (SP), Brazil.

Granuloma faciale is a rare, chronic dermatologic disorder, which mainly affects the face. Recently, dermoscopy has been demonstrated as an important ancillary tool on the clinical diagnosis of facial dermatoses. We report two cases of granuloma faciale with yellow areas on dermoscopy that was not yet described in the literature, corresponding to abundant hemosiderin on histopathological examination. Read More

An Bras Dermatol 2018 Jul-Aug;93(4):566-569

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu (SP), Brazil.

Amicrobial pustulosis of the folds is a chronic relapsing neutrophilic dermatosis characterized by sterile pustules compromising skin folds, scalp, face and periorificial regions. It predominantly affects women. Demodicosis is an inflammatory disease associated with cutaneous overpopulation of the mite Demodex spp. Read More

Acta Dermatovenerol Croat 2017 Dec;25(4):300-302

Dario Didona, MD, Prima Divisione Dermatologia Istituto Dermopatico dell'Immacolata, Via dei Monti di Creta 104, 00167 Rome , Italy;

Dear Editor, Reticulate pigmentary disorders (RPD) is a term used to classify a spectrum of several acquired and congenital disorders. Different clinical features can be present, including a reticular pattern and a freckle-like pattern with hyper- or hypo-pigmented macules (1). Dowling-Degos disease (DDD), an autosomal dominant genodermatosis, is the main type of RPD (2). Read More

Int J Dermatol 2018 11 2;57(11):1299-1300. Epub 2018 Jul 2.

Dermatology Department, Research Unit "Genodermatoses and cancers" LR12SP03, Habib Thameur Hospital, Tunis, Tunisia.

Pediatr Dermatol 2018 Sep 1;35(5):e308-e309. Epub 2018 Jul 1.

Department of Dermatology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.

Idiopathic facial aseptic granuloma is a recently described condition with defined clinical features, natural history, and underlying histopathologic findings. Several reports have recently described the potential diagnostic usefulness of ultrasound findings in idiopathic facial aseptic granuloma. We describe herein the dermoscopic features of idiopathic facial aseptic granuloma. Read More

Int J Dermatol 2018 Nov 21;57(11):1283-1292. Epub 2018 Jun 21.

National Skin Centre, Singapore, Singapore.

Hydroa vaccinforme-like lymphoproliferative disorder (HVLPD) is a rare T-cell lymphoproliferative disorder driven by the Epstein-Barr Virus (EBV). It was initially designated under the 2008 WHO classification of tumors of hematopoietic and lymphoid tissues as a distinct entity but has been recently reclassified as a lymphoproliferative disorder under the 2016 revision of the 2008 WHO classification of lymphoid malignancies. HVLPD mainly affects Asian, Central, and South American children. Read More

An Bras Dermatol 2018 Jun;93(3):391-396

Department of Dermatology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Background: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL.

Objective: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. Read More

Saudi Med J 2018 Jun;39(6):627-631

Department of Immunology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia. E-mail.

Objectives: To elucidate the clinico-laboratory characteristics associated with pediatric systemic lupus erythematosus (pSLE) patients with higher Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score in a retrospective cohort of pSLE patients.

Methods: A retrospective study involving 32 pSLE patients was conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia between 2006 and 2017.

Results: Within the group of 32 pSLE patients, 23 were girls and 9 were boys (3:1 ratio). Read More

Presse Med 2018 Jul - Aug;47(7-8 Pt 1):702-704. Epub 2018 Jun 13.

Hôpital Farhat Hached, service de dermatologie, avenue Ibn Jazzar, 4000 Sousse, Tunisie.

J Dermatol 2018 Sep 15;45(9):1122-1125. Epub 2018 Jun 15.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

Granuloma faciale (GF) is a rare chronic dermatosis with still unknown etiopathology, which usually presents a solitary, asymptomatic, smooth reddish-brown to violaceous plaques or nodules on the face. Various therapeutic approaches, including topical application of corticosteroid or tacrolimus and removal with laser, cryotherapy and surgery have been attempted; however, the outcome has been inconsistent. Herein, we report a case of perinasal nodular GF who repeatedly underwent surgical excisions after the failure of laser treatment. Read More

Infect Drug Resist 2018 22;11:751-760. Epub 2018 May 22.

Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.

Majocchi's granuloma (MG) is a rare fungal infection of the dermis that is mainly caused by dermatophytes (in ≥95% of cases); the most frequently identified cause is anthropophilic . In the rest of the cases, the causes are non-dermatophytic fungi such as species. This review aimed to provide information about the current perspectives on MG regarding its clinical characteristics, predisposing factors, laboratory diagnosis, and treatment strategies. Read More

J Am Acad Dermatol 2018 09 31;79(3):e57-e59. Epub 2018 May 31.

Allergan plc, Irvine, California.

Rev Med Chil 2018 Jan;146(1):107-110

Unidad de Melanoma y Cáncer de Piel, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Trichodysplasia spinulosa is a rare disease that occurs in the setting of immunosuppression, associated with tolerogenic therapy used in allograft recipients or patients with hematologic malignancies. Clinically, it is characterized by a centrofacial cutaneous eruption of erythematous papules with a central keratinous spicule, often associated with variable degrees of alopecia. Histologic findings are characteristic, and electron microscopy reveals the presence of trichodysplasia spinulosa associated polyomavirus. Read More