95,451 results match your criteria Fatty Liver

Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD.

Dev Cell 2022 Jun 23. Epub 2022 Jun 23.

Team Proliferation, Stress and Liver Physiopathology, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université Paris-Cité, 75006 Paris, France. Electronic address:

Non-alcoholic steatotic liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD has a major effect on the intrinsic proliferative properties of hepatocytes. Here, we investigated the mechanisms underlying the activation of DNA damage response during NAFLD. Read More

View Article and Full-Text PDF

Reversal of diabesity: Normalization of insulin release curve in association with reversal of non-alcoholic fatty liver disease.

Ann Nutr Metab 2022 Jun 29. Epub 2022 Jun 29.

Objective: Type 2 diabetes with obesity is regarded as an incurable, progressive disease with many complications. The hypothesis was tested that HbA1c and the insulin release curve can be restored by traceable systematic methods.

Methods: 122 people with diabesity were investigated before and after three and six months of traceable systematic management methods. Read More

View Article and Full-Text PDF

Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir Treatment for Chronic Hepatitis B Virus: A Reconstructed Individual Patient Data Meta-analysis.

JAMA Netw Open 2022 Jun 1;5(6):e2219407. Epub 2022 Jun 1.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Importance: Conventional meta-analyses with aggregated study-level data have yielded conflicting results for the comparative effectiveness of tenofovir disoproxil fumarate vs entecavir in reducing hepatocellular carcinoma (HCC) risk among patients with chronic hepatitis B virus. Within-study heterogeneity, between-study heterogeneity, and the inability of conventional meta-analyses to capture time-to-event data were associated with these results.

Objective: To perform a reconstructed individual patient data meta-analysis of high-quality propensity score-matched studies to provide robust estimates for comparative HCC risk between groups receiving tenofovir or entecavir. Read More

View Article and Full-Text PDF

SARS-CoV-2 infection and liver involvement.

Hepatol Int 2022 Jun 29. Epub 2022 Jun 29.

The Roger Williams Institute of Hepatology, Foundation for Liver Research, London, UK.

The COVID-19 pandemic is the largest public health challenge in living memory. Patients with underlying liver disease have been disproportionately affected, experiencing high morbidity and mortality. In addition, elevated liver enzymes appear to be a risk factor for disease progression, even in the absence of underlying liver disease. Read More

View Article and Full-Text PDF

Persimmon Water Extract Suppresses Hepatic Lipotoxicity by Regulating Lipid Metabolites.

J Med Food 2022 Jun 29. Epub 2022 Jun 29.

Division of Applied Life Science (BK21), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, Korea.

This study was performed to investigate the effects of persimmon () on high-fat diet (HFD)-induced hepatic lipotoxicity. The compounds of persimmon water extract (PWE) were identified as gallic acid, glucogallin, 1-O-Galloyl-(2-O-acetyl)-glu, and trihydroxy-octadecadienoic acid. The PWE was ingested by C57BL/6 mice with an HFD for 8 weeks. Read More

View Article and Full-Text PDF

Paying the Iron Price: Liver Iron Homeostasis and Metabolic Disease.

Compr Physiol 2022 Jun 29;12(3):3641-3663. Epub 2022 Jun 29.

Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

Iron is an essential metal element whose bioavailability is tightly regulated. Under normal conditions, systemic and cellular iron homeostases are synchronized for optimal function, based on the needs of each system. During metabolic dysfunction, this synchrony is lost, and markers of systemic iron homeostasis are no longer coupled to the iron status of key metabolic organs such as the liver and adipose tissue. Read More

View Article and Full-Text PDF

A narrative review on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis versus hepatocellular carcinoma: do you mind?

Rev Assoc Med Bras (1992) 2022 24;68(6):871-874. Epub 2022 Jun 24.

nonu University, Faculty of Medicine, Department of Surgery, Liver Transplantation Institute - Malatya, Turkey.

View Article and Full-Text PDF

Metabolic dysfunction associated fatty liver disease (MAFLD) and serum vitamin D concentration in South Korea.

Asia Pac J Clin Nutr 2022 ;31(2):201-207

Department of Family Medicine, Wonkwang University Hospital, Iksan, South Korea. Email:

Background And Objectives: Non-alcoholic fatty liver disease (NAFLD) has recently been renamed as metabolic dysfunction-associated fatty liver disease (MAFLD) by the Asian Pacific Association for the Study of the Liver (APASL) to reflect metabolic dysfunction. Vitamin D regulates free fatty acid flux from the periphery to the liver. The association MAFLD and vitamin D has been controversial. Read More

View Article and Full-Text PDF
January 2022

Fibrosis Risk in Nonalcoholic Fatty Liver Disease is Related to Chronic Kidney Disease in Aged Type 2 Diabetes Patients.

J Clin Endocrinol Metab 2022 Jun 29. Epub 2022 Jun 29.

Department of Endocrinology, The Fifth People's Hospital of Shanghai, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, China.

Context: Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease, associated with fibrosis and an increased risk of type 2 diabetes (T2DM) and chronic kidney disease (CKD).

Objective: To investigate the association of NAFLD fibrosis with development of CKD in aged patients with T2DM.

Design And Patients: This cross-sectional study enrolled 13915 participants. Read More

View Article and Full-Text PDF

Threonine supplementation prevents the development of fat deposition in mice fed a high-fat diet.

Food Funct 2022 Jun 29. Epub 2022 Jun 29.

Institute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030, China.

Obesity is the main factor involved in the onset of many diseases. Threonine supplementation has been demonstrated to reduce fat mass and serum triglycerides in already obese mice. However, it is unclear whether threonine could inhibit the development of obesity in mice without previous high-fat diet induction. Read More

View Article and Full-Text PDF

Anti-diabetic effect of banana peel dietary fibers on type 2 diabetic mellitus mice induced by streptozotocin and high-sugar and high-fat diet.

J Food Biochem 2022 Jun 29:e14275. Epub 2022 Jun 29.

Engineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, Anhui, PR China.

We used a high-fat diet (HFD) and streptozotocin (STZ) to induce type 2 diabetic mellitus (T2DM) mice and evaluated the effect of banana peel dietary fibers (BP-DFs) as potential hypoglycemic agents. After 5 weeks of intervention with banana peel dietary fibers (BP-DFs), food intake was reduced, body weight was increased, blood lipids and glucose were reduced, fasting insulin and GLP-1 levels were increased, and liver and pancreatic tissue damage was reduced. Banana peel soluble dietary fiber (BP-SDF) has the most significant effect. Read More

View Article and Full-Text PDF

The liver-gut peripheral neural axis and nonalcoholic fatty liver disease pathologies via hepatic serotonin receptor 2A.

Dis Model Mech 2022 Jun 29. Epub 2022 Jun 29.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, 951-8510, Japan.

Serotonin (5-HT) is one of the key bioamines of nonalcoholic fatty liver disease (NAFLD). Its mechanism via autonomic neural signal pathways remains unexplained; hence, we evaluated the involvement of 5-HT and related-signaling pathways via autonomic nerves in NAFLD. Diet-induced NAFLD animal models were developed using wild-type and melanocortin 4 receptor knockout (MC4RKO) mice, and the effects of autonomic neural axis on NAFLD physiology, 5-HT and its receptors (Htrs), and lipid metabolism-related genes were assessed applying hepatic nerve blockade. Read More

View Article and Full-Text PDF

Accuracy of attenuation imaging in the assessment of pediatric hepatic steatosis: correlation with the controlled attenuation parameter.

Ultrasonography 2022 Mar 5. Epub 2022 Mar 5.

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: This study evaluated the accuracy of attenuation imaging (ATI) for the assessment of hepatic steatosis in pediatric patients, in comparison with the FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP).

Methods: Consecutive pediatric patients referred for evaluation of obesity who underwent both ATI and FibroScan between February 2020 and September 2021 were included. The correlation between attenuation coefficient (AC) and CAP values was assessed using the Spearman test. Read More

View Article and Full-Text PDF

Growth hormone deficiency and NAFLD: An overlooked and underrecognized link.

Hepatol Commun 2022 Jun 28. Epub 2022 Jun 28.

Gastroenterology and Hepatology Department, Mayo Clinic, Rochester, Minnesota, USA.

Growth hormone and its mediator insulin-like growth factor-1 exert their effect on different organs and control various physiologic metabolic processes. Adult growth hormone deficiency (AGHD) presents with one or more components of metabolic syndrome and can be associated with nonalcoholic fatty liver disease (NAFLD). AGHD is present in spectrum of hypothalamic/pituitary disorders as well as cranial radiation of brain tumors and often remains underdiagnosed or untreated due to its nonspecific symptoms, relatively difficult diagnosis in some clinical scenarios, and various barriers to treatment. Read More

View Article and Full-Text PDF

Red Blood Cell-Conditioned Media from Non-Alcoholic Fatty Liver Disease Patients Contain Increased MCP1 and Induce TNF-α Release.

Rep Biochem Mol Biol 2022 Apr;11(1):54-62

Laboratory of Biochemistry, Department of Medicine, Democritus University of Thrace, Greece.

Background: Non-alcoholic fatty liver disease (NAFLD) constitutes a global pandemic. An intricate network among cytokines and lipids possesses a central role in NAFLD pathogenesis. Red blood cells comprise an important source of both cytokines and signaling lipids and have an important role in molecular crosstalk during immunometabolic deregulation. Read More

View Article and Full-Text PDF

The Role of Thiazolidinediones in the Amelioration of Nonalcoholic Fatty Liver Disease: A Systematic Review.

Cureus 2022 May 27;14(5):e25380. Epub 2022 May 27.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Non-alcoholic fatty liver disease (NAFLD) is a broad term encompassing hepatic steatosis and non-alcoholic steatohepatitis (NASH), a form of chronic hepatitis. This may, unfortunately, lead to terminal complications like cirrhosis and hepatocellular carcinoma (HCC). NAFLD is strongly associated with obesity, type 2 diabetes (T2DM), hypertension, and metabolic syndrome. Read More

View Article and Full-Text PDF

Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation.

Cell Biosci 2022 Jun 28;12(1):99. Epub 2022 Jun 28.

Department of Anatomy, Chonnam National University Medical School, Hwasun, Jeollanam-do, 58128, Republic of Korea.

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin resistance, cerebrovascular dysfunction, gut dysbiosis, and neuroinflammation. Many recent studies have focused on the increasing prevalence of dementia in patients with NAFLD. Read More

View Article and Full-Text PDF

Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome.

J Transl Med 2022 Jun 28;20(1):294. Epub 2022 Jun 28.

Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No.528 Zhangheng Road Pudong New District, Shanghai, 201203, China.

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and has become a huge public health issue worldwide. Inhibition of nucleotide oligomerization domain-like receptors containing pyrin domain 3 (NLRP3) inflammasome is a potential therapeutic strategy for NAFLD. Currently, there are no drugs targeting NLRP3 inflammasome for clinical treatment of NAFLD. Read More

View Article and Full-Text PDF

Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Osteoporos Int 2022 Jun 28. Epub 2022 Jun 28.

The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.

The aim of this study was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and NAFLD. Patients with NAFLD should be monitored regularly for bone mineral density and bone metabolism indicators to prevent osteoporosis or osteoporotic fractures.

Objectives: The aim of this meta-analysis was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and non-alcoholic fatty liver disease (NAFLD). Read More

View Article and Full-Text PDF

[Comparison of criteria for metabolically healthy overweight/obesity in Shanghai Changfeng study].

Q Wu S Ma H D Lin X Gao

Zhonghua Nei Ke Za Zhi 2022 Jul;61(7):771-778

Department of Endocrinology, Zhongshan Hospital, Fudan Institute for Metabolic Disease, Human Phenome Institute, Fudan University, Shanghai 200032, China.

To establish a more suitable and practicable criterion of metabolically healthy overweight/obesity (MHO/O) in Chinese, a comparison study on different criteria of MHO/O was conducted in subjects aged over 45-year-old in Shanghai Changfeng Community. A total of 3 301 overweight/obese subjects over 45 years old (men 1 521, women 1 789) in Shanghai Changfeng Community was included in the study. According to the inclusion or exclusion of waist circumference (WC), homeostasis model assessment of insulin resistance (HOMA-IR) ≥2. Read More

View Article and Full-Text PDF

[Activation of cGAS/STING signaling pathway and its immunological role in the progression of nonalcoholic fatty liver disease].

Zhonghua Gan Zang Bing Za Zhi 2022 May;30(5):564-568

Department of Immunology, Medical School of Nantong University, Nantong 226001, China.

Today, nonalcoholic fatty liver disease remains the most dominant chronic liver disease. Cyclic guanosine monophosphate-adenosine monosphosphate synthase (cGAS) is a cytosolic DNA sensor that catalyzes the synthesis of cyclic guanosine monophosphate, activates stimulator of interferon genes (STING), and releases type-I interferon cytokines to trigger immune responses. Exogenous or endogenous DNA acts as a cGAS ligand to activate the cGAS-STING signaling pathway, which plays a role in hepatitis, nonalcoholic fatty liver disease, liver cancer and other diseases, and affects liver disease progression and metabolism through mechanisms such as autophagy. Read More

View Article and Full-Text PDF

Exploring therapeutic mechanisms of San-Huang-Tang in nonalcoholic fatty liver disease through network pharmacology and experimental validation.

J Ethnopharmacol 2022 Jun 25:115477. Epub 2022 Jun 25.

Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address:

Ethnopharmacological Relevance: San-Huang-Tang (SHT), a traditional Chinese medicine (TCM) formula, has been clinically used to treat obesity and type 2 diabetes mellitus. Recently it has proved that SHT have a good effect on non-alcoholic fatty liver disease (NAFLD).

Aim Of The Study: Our study was designed to investigate the therapeutic mechanisms of the SHT against NAFLD. Read More

View Article and Full-Text PDF

fight fatty liver.

Sci Signal 2022 Jun 28;15(740):eadd6194. Epub 2022 Jun 28.

Science Signaling, AAAS, Washington, DC 20005, USA. Email:

Sphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis. Read More

View Article and Full-Text PDF

Slightly different metabolomic profiles are associated with high or low weight duck foie gras.

PLoS One 2022 28;17(6):e0255707. Epub 2022 Jun 28.

GenPhySE, Université de Toulouse, INRAE, ENVT, Castanet Tolosan, France.

Understanding the evolution of fatty liver metabolism of ducks is a recurrent issue for researchers and industry. Indeed, the increase in weight during the overfeeding period leads to an important change in the liver metabolism. However, liver weight is highly variable at the end of overfeeding within a batch of animals reared, force-fed and slaughtered in the same way. Read More

View Article and Full-Text PDF

Therapeutic Potential of Artichoke in the Treatment of Fatty Liver: A Systematic Review and Meta-Analysis.

J Med Food 2022 Jun 28. Epub 2022 Jun 28.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Nonalcoholic fatty liver disease (NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and death. Artichoke leaf extract (ALE) is well known in folk medicine for its hepatoprotective effect. Till recent times, no sufficient data from randomized clinical trials (RCTs) exist to support such use. Read More

View Article and Full-Text PDF

Intragastric Balloon in Obese Compensated Nonalcoholic Steatohepatitis Cirrhosis Patients Is Safe and Achieves Significant Weight Reduction at 6-Months.

Dig Dis Sci 2022 Jun 28. Epub 2022 Jun 28.

Department of Gastroenterology, Artemis Hospitals, Gurugram, Haryana, India.

Background And Study Aims: Weight reduction is the mainstay treatment for Nonalcoholic steatohepatitis (NASH). intragastric balloon (IGB) placement has proven benefit in terms of weight reduction. The aim of the present study is to assess the safety and efficacy of IGB placement in compensated NASH cirrhosis. Read More

View Article and Full-Text PDF

Thyroid stimulating hormone levels are associated with genetically predicted nonalcoholic fatty liver disease.

J Clin Endocrinol Metab 2022 Jun 28. Epub 2022 Jun 28.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China. Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, China.

Context: Findings of observational studies indicated an association of thyroid hormone levels with the risk of nonalcoholic fatty liver disease (NAFLD), whereas conflicting results remained and might be subject to reverse causality.

Objective: This study aimed to evaluate the associations between NAFLD and both plasma thyroxine (T4) and thyroid stimulating hormone (TSH) at the phenotypic and genetic levels.

Methods: We included 14,797 participants, aged 20 - 74 years and had undergone abdominal ultrasonography during the Third National Health and Nutrition Examination Survey (NHANES III). Read More

View Article and Full-Text PDF

Omega-3 fatty acids and metabolic partitioning of fatty acids within the liver in the context of nonalcoholic fatty liver disease.

Philip C Calder

Curr Opin Clin Nutr Metab Care 2022 Jul;25(4):248-255

School of Human Development and Health, Faculty of Medicine, University of Southampton.

Purpose Of Review: Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent form of liver disease globally, affecting about 25% of the world's adult population. It is more common in those living with obesity, where it may affect as many as 80% of individuals. The aim of this article is to describe recent human studies evaluating the influence of omega-3 fatty acids on de novo lipogenesis (DNL) and hepatic fatty acid partitioning between incorporation into triacylglycerols (TAGs) and β-oxidation, to discuss the relevance of these effects in the context of NAFLD, and to provide an overview of the mechanisms that might be involved. Read More

View Article and Full-Text PDF

Intrahepatic triglyceride content: influence of metabolic and genetics drivers.

Curr Opin Clin Nutr Metab Care 2022 Jul;25(4):241-247

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford.

Purpose Of Review: Intrahepatic triglyceride (IHTG) content is determined by substrate flux to, fatty acid synthesis and partitioning within, and triglyceride disposal from the liver. Dysregulation of these processes may cause IHTG accumulation, potentially leading to nonalcoholic fatty liver disease. The aetiology of IHTG accumulation has not been fully elucidated; however, environmental factors and heritability are important. Read More

View Article and Full-Text PDF

Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.

J Cell Physiol 2022 Jun 27. Epub 2022 Jun 27.

Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain.

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represents a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different nonalcoholic fatty liver disease mouse models. In the present work, we are interested in elucidating the molecular mechanisms reducing SHBG plasma levels in liver fibrosis. Read More

View Article and Full-Text PDF