1,155,983 results match your criteria Family medicine[Journal]


The state of bereavement support in adult intensive care: A systematic review and narrative synthesis.

J Crit Care 2018 Dec 1;50:177-187. Epub 2018 Dec 1.

University of Ottawa, Faculty of Health Sciences, School of Nursing, 3245B Roger Guindon Hall, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:

Purpose: Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first review to investigate the state of ICU bereavement support globally, and the availability and effectiveness of bereavement support interventions.

Methods: A systematic review and narrative synthesis. Read More

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December 2018
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Program implementer perspectives replicating evidence based sexual reproductive health programs.

Eval Program Plann 2018 Dec 6;73:80-87. Epub 2018 Dec 6.

The Johns Hopkins Center for Child & Community Health, Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, Suite 4200, Mason F. Lord Building, Center Tower, Baltimore, MD 21224, United States.

Purpose: Explore factors affecting implementation of evidence based adolescent sexual/reproductive health programs, from the perspectives of program implementers.

Methods: In-depth interviews were conducted with 18 program implementers delivering six sexual/reproductive health programs in New Jersey. Programs were delivered among 2698 primarily African American and Hispanic adolescents in school and community-based settings. Read More

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December 2018
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Molecular basis of Tityus stigmurus alpha toxin and potassium channel kV1.2 interactions.

J Mol Graph Model 2018 Nov 28;87:197-203. Epub 2018 Nov 28.

Department of Pharmacy, Universidade Federal do Rio Grande do Norte (UFRN), Natal, 59010-180, Brazil. Electronic address:

The Tityus stigmurus scorpion is widely distributed in the Northeast of Brazil and is the main causal agent of human envenoming. The venom produced by this scorpion includes neurotoxins, which are peptides belonging to Family 2 toxins and are able to interact with ion channels. The KTx subfamily displays selectivity and affinity for Kv channel subtypes and the result of this interaction is the blockade of potassium channels, impairing vital functions. Read More

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November 2018

An exploration of the psychometric properties of the SATAQ-4 among adolescent boys in Japan.

Eat Behav 2018 Dec 6;32:31-36. Epub 2018 Dec 6.

Department of Psychology, University of South Florida, Tampa, FL, USA.

Research among Western adult and adolescent males suggests that sociocultural influences are implicated in the drive for muscularity and weight-change behaviors. However, few studies have examined these relationships among adolescent boys from non-Western backgrounds. The current study sought to assess the psychometric properties of the Sociocultural Attitudes Towards Appearance Questionnaire-4 (SATAQ-4), a 22-item, 5-factor measure of sociocultural influence on appearance ideals, among Japanese (n = 984) adolescent boys. Read More

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December 2018
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Design of a randomized controlled trial on the efficacy of a reproductive health survivorship care plan in young breast cancer survivors.

Contemp Clin Trials 2018 Dec 12. Epub 2018 Dec 12.

Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Dr. La Jolla, CA 92093-090, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, 9300 Campus Pointe Drive, MC 7433, La Jolla, CA 92037, USA. Electronic address:

Background: Young breast cancer survivors (YBCS) have unmet needs for managing hot flashes, fertility-related concerns, sexual health and contraception.

Purpose: Describe the design and participant characteristics of a randomized controlled trial testing the efficacy of the survivorship care plan on reproductive health (SCP-R) intervention on improving hot flashes, fertility-related concerns, sexual health, and contraception in YBCS.

Methods: SCP-R is a web-based intervention with text message support encompassing evidence- based practices on four reproductive health issues. Read More

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December 2018

Maternal childhood emotional abuse predicts Chinese infant behavior problems: Examining mediating and moderating processes.

Child Abuse Negl 2018 Dec 12;88:307-316. Epub 2018 Dec 12.

Beijing Key Laboratory of Learning and Cognition, Research Center for Child Development, School of Psychology, Capital Normal University, China.

The current study examined the mediating effect of maternal negative expressiveness as well as the moderating effects of infant inhibitory control (IC) in the association between maternal childhood emotional abuse (CEA) and infant behavior problems. Drawing from 207 families from mainland China, 2-wave data were reported in this study when the infants were 6 months (T1) and 14 (T2) months. Mothers (Mean age = 32. Read More

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December 2018

Are parents at a higher risk for secondary traumatic stress?: How interviewing child victims impacts relationships with forensic interviewer's friends and family.

Child Abuse Negl 2018 Dec 12;88:275-287. Epub 2018 Dec 12.

School of Arts & Sciences, University of Houston-Victoria, 3007 N. Ben Wilson, Victoria, TX, 77904, United States. Electronic address:

Background: Forensic interviewers are at a heightened risk for secondary traumatic stress (STS) due to their frequent interactions with victims of child maltreatment (Bonach & Heckert, 2012). To date, however, few studies have examined the negative effects of this work on interviewers' social and emotional well-being.

Objective: The present study seeks to explore the effect of STS on the relationships of forensic interviewers, including those with friends, family, and their respective children. Read More

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December 2018

Effective communication in the era of precision medicine: A pilot intervention with low health literacy patients to improve genetic counseling communication.

Eur J Med Genet 2018 Dec 12. Epub 2018 Dec 12.

Department of Social & Behavioral Sciences, University of California, San Francisco, United States.

Effective communication, where all parties share a common understanding, is necessary to realize the promise of Genomic Medicine. It is especially salient given the imperative to increase the participation of diverse populations in genomics research and to expand the reach of clinical genomics. We have previously shown that cancer genetic counseling is suboptimal for patients with limited health literacy. Read More

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December 2018
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The role of SRC family kinases in FLT3 signaling.

Int J Biochem Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden; Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden; Division of Oncology, Skåne University Hospital, Lund, Sweden. Electronic address:

The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Read More

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December 2018
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Identification of a novel mutation in FBN1 in a Chinese family with inherited ectopia lentis by targeted NGS.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Aier School of Ophthalmology, Central South University, Tianxin District, Changsha, Hunan Province 410015, China; WuhanAier Eye Hospital, Aier Eye Hospital Group, Wuchuan District, Wuhan, Hubei Province 430063, China. Electronic address:

Aims: To diagnose a Chinese family with inherited ectopia lentis in a genetic method and analyze the genotype-phenotype correlation.

Methods: The phenotype of each family member was identified by detailed clinical examination. We used targeted next generation sequencing (NGS) to identify mutations in FBN1 in an efficient and accurate way. Read More

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December 2018

Assembling a genome for novel nitrogen-fixing bacteria with capabilities for utilization of aromatic hydrocarbons.

Genomics 2018 Dec 12. Epub 2018 Dec 12.

CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India. Electronic address:

Metagenome from refinery wastewater treatment plant running under nitrogen stress was analyzed for mining of novel aromatic hydrocarbon-degrading bacteria. The sequence data were assembled using metaspade followed by binning using the Metabat tool to assemble genome; where coverage and depth were calculated using bowtie and samtools. The analysis picked a novel genome belonging to family Bradyrhizobiaceae, identified based on 16S rDNA gene which was supported by CheckM and Kraken analysis. Read More

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December 2018

Women's perspectives about cannabis use during pregnancy and the postpartum period: An integrative review.

Prev Med 2018 Dec 12. Epub 2018 Dec 12.

University of British Columbia, Vancouver, BC, Canada.

Cannabis is the most commonly used illicit drug among general and pregnant populations. Despite recommendations to abstain from cannabis use, its use is increasing during the perinatal period. In this integrative review, we aim to understand women's perspectives about the health aspects of perinatal cannabis use. Read More

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December 2018
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Cardiopulmonary Bypass Time Predicts Early Postoperative Enterobacteriaceae Bloodstream Infection.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Cardiovascular Surgery, Department of Surgery, E-DA hospital and College of Medicine, I-Shou University, Kaohsiung, Taiwan. Electronic address:

Background: A bloodstream infection in patients undergoing cardiovascular surgery is crucial because it can result in significantly worse outcomes. However, microbiological patterns have rarely been investigated in these patients.

Methods: We retrospectively reviewed the data of 1,041 adult patients undergoing cardiovascular surgeries using cardiopulmonary bypass from January 2013 to December 2017 at the National Cheng Kung University Hospital, Tainan, Taiwan. Read More

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December 2018

What makes internal medicine attractive for the millennial generation? A survey of residents in internal medicine in Switzerland.

Swiss Med Wkly 2018 Dec 15;148:w14696. Epub 2018 Dec 15.

Department of Internal Medicine, Kantonsspital Olten, Switzerland.

Aims: A new generation of physicians, millennials (also known as Generation Y), are entering residency programmes in internal medicine, and these young men and women learn and work in ways that are different from those of past generations. The aim of the present study was to investigate aspects contributing to the attractiveness to young residents of a career in general internal medicine (GIM) compared with medical subspecialties (SUB).

Methods: In a cross-sectional online survey, we included residents working in residency facilities in GIM in German-speaking Switzerland. Read More

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December 2018

Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: A large-scale prospective study.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.

Background: To develop and validate practical prognostic indexes (PIs) for predicting the prognosis and response to postoperative adjuvant therapy in patients with oral squamous cell carcinoma (OSCC).

Methods: A large cohort of 1071 OSCC patients were randomized to either training set (N = 708) or validation set (N = 363). Three types of PIs were developed according to the nomogram scores, β coefficients and excess hazard ratios, respectively. Read More

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December 2018
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TiS2 Monolayer Emerging as Ultrathin Bifunctional Catalyst: Influence of Defect and Functionalization.

Chemphyschem 2018 Dec 15. Epub 2018 Dec 15.

Department of Materials Science, Indian Association for the Cultivation of Science,Jadavpur, Kolkata-700032,India., INDIA.

We have envisaged the hydrogen evolution and oxygen evolution reaction (HER and OER) on two-dimensional (2D) noble metal free titanium disulfide TiS2 monolayer, which belongs to the exciting family of transition metal dichalcogenides (TMDCs). Our theoretical investigation to probe HER and OER on both H- and T- phase of 2D TiS2 is based on the electronic structure calculations witihin the framework of Density Functional Theory (DFT). Since TiS2 is the lightest element among the group IV transition metal dichalocogenides, it is worth exploring the catalytic activity of TiS2 monolayer through the functionalization at the anion (S) site substituting with P, N and C dopants as well as by incorporating single sulfur vacancy defect. Read More

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December 2018

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.

Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.

Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. Read More

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December 2018

The structure of mammalian β-mannosidase provides insight into β-mannosidosis and Nystagmus.

FEBS J 2018 Dec 15. Epub 2018 Dec 15.

Department of Biochemistry and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, QC, H3G 0B1, Canada.

β-mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the non-reducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway. Mutations in the MANBA gene, which encodes the β-mannosidase, can lead to the lysosomal storage disease β-mannosidosis, as well as nystagmus, an eye condition characterized by involuntary eye movements. Here, we present the first structures of a mammalian β-mannosidase in both the apo and mannose-bound forms. Read More

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December 2018
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Caring by Telecare? A Hermeneutic Study of Experiences among Older Adults and Their Family Caregivers.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

Department of Health and Nursing Sciences, University of Agder, Norway.

Aims And Objectives: The purpose of this study was to obtain a deeper understanding of the persistent use of telecare for older adults and their family caregivers.

Background: Telecare is seen as part of the solution in home care services for ageing in place. Previous studies have shown that telecare is a complex intervention, and there is still a poor understanding of older adults' and their family caregivers' experience with the use of telecare. Read More

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December 2018

Variability in sleep disturbance, physical activity and quality of life according to level of depressive symptoms in women with Type 2 diabetes.

Diabet Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Social Sciences and Health Policy, Wake Forest School of Medicine.

Aims: To examine (1) the prevalence of depressive symptoms in women with Type 2 diabetes, (2) the associations between depressive symptoms and the following dependent variables: sleep disturbance; physical activity; physical health-related; and global quality of life, and (3) the potential moderating effects of antidepressants and optimism on the relationship between depressive symptoms and dependent variables.

Methods: Participants in the Women's Health Initiative who had Type 2 diabetes and data on depressive symptoms (N=8895) were included in the analyses. In multivariable linear regression models controlling for sociodemographic, medical and psychosocial covariates, we examined the main effect of depressive symptoms, as well as the interactions between depressive symptoms and antidepressant use, and between depressive symptoms and optimism, on sleep disturbance, physical activity, physical health-related quality of life and global quality of life. Read More

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December 2018
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Realizing Relational Preferences Through Transforming Interpersonal Patterns.

Fam Process 2018 Dec 15. Epub 2018 Dec 15.

School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.

Family therapy has often been conceptualized as a conversational process whereby therapists and clients generate new meanings. Based on a 3-year study of conversational practices observable in successful family therapy processes of Chilean families with a child/adolescent who is engaged in disruptive behaviors, we looked for clinical examples of Transforming Interpersonal Patterns (TIPs). TIPs are a key aspect of the IPscope, a framework we used to explore the meaning-making processes in family therapy. Read More

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December 2018
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EMBRace: Developing a Racial Socialization Intervention to Reduce Racial Stress and Enhance Racial Coping among Black Parents and Adolescents.

Fam Process 2018 Dec 15. Epub 2018 Dec 15.

Graduate School of Education, University of Pennsylvania, Philadelphia, PA.

Researchers have illustrated the deleterious psychological effects that racial discrimination has exerted on Black Americans. The resulting racial stress and trauma (RST) from experiences with discrimination has been linked to negative wellness outcomes and trajectories for Black youth and families. Racial socialization (RS)-defined as the verbal and nonverbal messages that families use to communicate race to their children-can be a cultural strength and has been associated with positive outcomes in Black youth. Read More

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December 2018

Design and visualization of second generation cyanoisoindole based fluorescent strigolactone analogs.

Plant J 2018 Dec 15. Epub 2018 Dec 15.

SynBioC Research Group, Department of Green Chemistry and Technology, Campus Coupure, Ghent University Coupure Links 653, 9000, Ghent, Belgium.

Strigolactones (SLs) are a family of terpenoid allelochemicals that were recognized as plant hormones only a decade ago. They influence a myriad of both above- and belowground developmental processes, and are an important survival strategy for plants in nutrient-deprived soils. A rapidly emerging approach to gain knowledge on hormone signaling is the use of traceable analogs. Read More

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December 2018

Selective mono-allylation of 1,3-diketones and their use in the synthesis of 3-allyl chromones and benzannulated 6,5-bicyclic ketals.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

University of Otago, Department of Chemistry, P.O. Box 56, 9054, Dunedin, NEW ZEALAND.

The selective mono-allylation of 1,3-diketone containing compounds is described. The reaction proceeds under mild reaction conditions and in moderate to high yield (66-99%). Using this procedure to access the key mono-allylated intermediate, the hitherto difficult to access, 3-allyl chromones were synthesized in excellent yield (87-98%). Read More

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December 2018

Efficacy of Mindfulness-Based Stress Reduction in Emerging Adults with Poorly Controlled, Type 1 Diabetes: A Pilot Randomized Controlled Trial.

Pediatr Diabetes 2018 Dec 15. Epub 2018 Dec 15.

Center for Mind-Body Research, Johns Hopkins University, Baltimore, MD.

Background And Objective: The negative effects of stress on persons with type 1 diabetes (T1D) are well-established, but effective interventions to reduce stress among emerging adults with T1D are limited. The study objective was to conduct a pilot randomized controlled trial (RCT) to obtain preliminary data on the efficacy of mindfulness-based stress reduction (MBSR) to reduce stress and improve diabetes health outcomes in a population of high-risk, urban emerging adults with poorly controlled diabetes METHODS: 48 participants aged 16-20 years of age with T1D (mean duration= 8 years) were randomly assigned to one of three conditions: MSBR, cognitive-behavioral stress management (CBSM), or a diabetes support group. Data were collected at baseline, end of treatment and three months after treatment completion. Read More

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December 2018

How Do Family Strengths-Oriented Therapeutic Conversations (FAM-SOTC) Advance Psychiatric Nursing Practice?

J Nurs Scholarsh 2018 Dec 15. Epub 2018 Dec 15.

Psychiatric Clinical Nurse Specialist, Landspitali University Hospital, Landspitali-The National University Hospital in Iceland, Child and Adolescent Psychiatric Division, Reykjavik, Iceland.

Purpose: Family nursing interventions, focusing on therapeutic conversations, have been found to benefit primary caregivers dealing with chronic and acute illnesses. Less is known, however, about the benefit of these interventions for partner caregivers. The aims of this study were to develop and test the Family Strengths-Oriented Therapeutic Conversation (FAM-SOTC) intervention for partner caregivers of young individuals with eating disorders (EDs). Read More

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December 2018
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Parents' experiences of donation to their child before kidney transplantation: A qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Institute, University of Southern, Denmark.

Aim And Objectives: To explore Parents' experiences of donation to their child before kidney transplantation.

Background: Transplantation is the treatment of choice for pediatric patients with end-stage renal disease. Living donor kidney transplantation has shown a higher long-term transplant survival compared to deceased donor transplantation and entails a more controllable process, with shorter waiting time. Read More

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December 2018

PUMA induction mediates acetaminophen-induced necrosis and liver injury.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

UPMC Hillman Cancer Center, Pittsburgh, PA, 15213, USA.

Acetaminophen (APAP) overdose is one of the leading causes of hepatotoxicity and acute liver failure in the United States. Accumulating evidence suggests that hepatocyte necrosis plays a critical role in APAP-induced liver injury. However, the mechanisms of APAP-induced necrosis and liver injury are not fully understood. Read More

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December 2018

Hereditary breast cancer; Genetic penetrance and current status with BRCA.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Menzies Health Institute Queensland, Gold Coast, QLD.

The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. Many BC susceptibility genes can be grouped into two classes, high- and low-penetrance genes, each of which interact with multiple genes and environmental factors. However, the penetrance of genes can also be represented by a spectrum, which ranges between high and low. Read More

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December 2018

Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism.

Clin Drug Investig 2018 Dec 14. Epub 2018 Dec 14.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Background And Objective: The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of dementia.

Methods: The study population included all adults (n = 12,057) aged ≥ 45 years with a diagnosis of atrial fibrillation at 75 primary care centers in Sweden during 2001-2007 without an earlier recorded dementia diagnosis. Read More

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December 2018

Alternative transcript imbalance underlying breast cancer susceptibility in a family carrying PALB2 c.3201+5G>T.

Breast Cancer Res Treat 2018 Dec 14. Epub 2018 Dec 14.

Oncogenetics Group, Vall d'Hebron Institute of Oncology, VHIO, 08035, Barcelona, Spain.

Purpose: Disruption of splicing motifs by genetic variants can affect the correct generation of mature mRNA molecules leading to aberrant transcripts. In some cases, variants may alter the physiological transcription profile composed of several transcripts, and an accurate in vitro evaluation is crucial to establish their pathogenicity. In this study, we have characterized a novel PALB2 variant c. Read More

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December 2018

Renaming of 'Candidatus Methylocucumis oryzae' as Methylocucumis oryzae gen. nov., sp. nov., a novel Type I methanotroph isolated from India.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

MACS Agharkar Research Institute, G.G. Agarkar Road, Pune, 411004, Maharashtra, India.

Candidatus Methylocucumis (Mcu.) oryzae, strain Sn10-6, a Gram-negative, pale pink pigmented, motile, large Type I methanotroph (3-6 µm × 1.5-2 µm) was recently isolated from an Indian rice field. Read More

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December 2018

The role of adverse childhood experiences and mental health care use in psychological dysfunction of male multi-problem young adults.

Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Department of Child and Adolescent Psychiatry, Amsterdam UMC, University of Amsterdam, Meibergdreef 5, 1105 AZ, Amsterdam, The Netherlands.

Adverse childhood experiences (ACEs) are associated with severe problems later in life. This study examines how eleven types of ACEs and mental health care use history are related to current psychological dysfunction among multi-problem young adults. A sample of 643 multi-problem young adult men (age 18-27) gave informed consent for us to collect retrospective regional psychiatric case register data and filled out questionnaires. Read More

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December 2018

Exploring the genetic diversity of Tylodelphys (Diesing, 1850) metacercariae in the cranial and body cavities of Mexican freshwater fishes using nuclear and mitochondrial DNA sequences, with the description of a new species.

Parasitol Res 2018 Dec 14. Epub 2018 Dec 14.

Departamento de Zoología, Instituto de Biología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Avenida Universidad 3000, 04510, Mexico, Distrito Federal, Mexico.

Members of the genus Tylodelphys Diesing, 1850 are endoparasites of fish-eating birds, particularly ciconiids, anhingids, and podicipedids across the globe. Metacercariae of Tylodelphys spp. were collected from the cranial and body cavities of freshwater fishes in central and northern Mexico; adults were recovered from the intestine of two species of freshwater diving birds of the family Podicipedidae, commonly known as grebes, in two locations of central Mexico. Read More

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December 2018

Selected Uncommon Legumes as a Source of Essential Fatty Acids, Tocopherols, Tocotrienols, Sterols, Carotenoids, and Squalene.

Plant Foods Hum Nutr 2018 Dec 14. Epub 2018 Dec 14.

School of Studies in Chemistry/Environmental Science, Pt. Ravishankar Shukla University, Raipur, CG, 492010, India.

The seeds of nine species belonging to the Fabaceae family (Cassia alata, Cassia uniflora, Cassia obtusifolia, Cassia tora, Crotalaria albida, Crotalaria juncea, Crotalaria pallida, Indigofera tinctoria, and Tephrosia purpurea) were studied. The oil yield ranged from 2.0 to 9. Read More

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December 2018
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Health Disparities among Children with Autism Spectrum Disorders: Analysis of the National Survey of Children's Health 2016.

J Autism Dev Disord 2018 Dec 14. Epub 2018 Dec 14.

Autism Speaks, 1060 State Rd, Princeton, NJ, USA.

Utilizing the 2016 National Survey of Children's Health, this study illustrates that children with ASD have nearly 4 times higher odds of unmet health care needs compared to children without disabilities, whereas children with other disabilities had nearly 2 times higher odds of unmet health care needs compared to children without disabilities. Applying Andersen's Behavioral Model of health care utilization, this study estimates that enabling factors (e.g. Read More

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December 2018

Out-of-home informal support important for medication adherence, diabetes distress, hemoglobin A1c among adults with type 2 diabetes.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Adults with type 2 diabetes mellitus (T2DM) often receive self-management support from adult children, siblings or close friends residing outside of their home. However, the role of out-of-home support in patients' self-management and well-being is unclear. Patients (N = 313) with HbA1c > 7. Read More

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December 2018
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Differential effects of nickel dosages on in vitro and in vivo seed germination and expression of a high affinity nickel-transport family protein (AT2G16800) in trembling aspen (Populus tremuloides).

Ecotoxicology 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Laurentian University, Sudbury, Ontario, P3E 2C6, Canada.

It has been demonstrated that a number of metals including mercury (Hg), zinc (Zn), cadmium (Cd), cobalt (Co), lead (Pb), copper (Cu), and nickel (Ni) decrease seed germination rates and plant growth. The threshold levels of metal toxicity on seed germination, plant development, and gene regulation have not been studied in detail. The main objective of this study was to assess in vitro and in vivo the effects of different doses of nickel on Trembling aspen (Populus tremuloides) seed germination and regulation of the high affinity nickel transporter family protein (AT2G16800) gene. Read More

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December 2018

A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion.

Virchows Arch 2018 Dec 14. Epub 2018 Dec 14.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

The renal cell carcinomas associated with Xp11 translocations (Xp11 translocation RCCs) harbor gene fusions involving TFE3, a member of the microphthalmia-associated transcription factor (MiTF) family. In the present study, we identified a novel partner of TFE3, Ewing sarcoma breakpoint region 1 (EWSR1), in an Xp11 translocation RCC. A 57-year-old Japanese woman without special disease history was referred to us for treatment of an RCC. Read More

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December 2018

Accuracy of within- and among-family genomic prediction for Fusarium head blight and Septoria tritici blotch in winter wheat.

Theor Appl Genet 2018 Dec 14. Epub 2018 Dec 14.

State Plant Breeding Institute, University of Hohenheim, Fruwirthstr. 21, 70599, Stuttgart, Germany.

Genomic selection is an approach that uses whole-genome marker data to predict breeding values of genotypes and holds the potential to improve the genetic gain in breeding programs. In this study, two winter wheat populations (DS1 and DS2) consisting of 438 and 585 lines derived from six and eight bi-parental families, respectively, were genotyped with genome-wide single nucleotide polymorphism markers and phenotyped for Fusarium head blight and Septoria tritici blotch severity, plant height and heading date. We used ridge regression-best linear unbiased prediction to investigate the potential of genomic selection under different selection scenarios: prediction across each winter wheat population, within- and among-family prediction in each population, and prediction from DS1 to DS2 and vice versa. Read More

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December 2018

How many cadherins do human endothelial cells express?

Cell Mol Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, C/Nicolás Cabrera 1, Cantoblanco, 28049, Madrid, Spain.

The vasculature is the paradigm of a compartment generated by parallel cellular barriers that aims to transport oxygen, nutrients and immune cells in complex organisms. Vascular barrier dysfunction leads to fatal acute and chronic inflammatory diseases. The endothelial barrier lines the inner side of vessels and is the main regulator of vascular permeability. Read More

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December 2018

Plasmodium falciparum infected erythrocytes can bind to host receptors integrins αVβ3 and αVβ6 through DBLδ1_D4 domain of PFL2665c PfEMP1 protein.

Sci Rep 2018 Dec 14;8(1):17871. Epub 2018 Dec 14.

Charles E. Schmidt College of Medicine, Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL, USA.

Major complications and mortality from Plasmodium falciparum malaria are associated with cytoadhesion of parasite-infected erythrocytes (IE). The main parasite ligands for cytoadhesion are members of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. Read More

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December 2018

Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages.

Cell Mol Immunol 2018 Dec 14. Epub 2018 Dec 14.

Institute for Immunology and School of Medicine, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, 100086, Beijing, China.

Classical signaling lymphocyte activating molecule (SLAM) family receptors are abundant within many types of immune cells, whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9, which uniquely lack cytoplasmic signaling motifs, are highly expressed by myeloid cells. Due to the potential redundancy, whether these two receptors regulate macrophage function remains largely unknown. Here, we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation. Read More

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December 2018

Microbial patterns in patients with histamine intolerance.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

First Department of Medicine, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, Germany.

Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels. Our aim was to determine the intestinal bacterial composition in patients with proven histamine intolerance in comparison to other food intolerances and healthy controls. Read More

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Spectrum and time course of epilepsy and the associated cognitive decline in duplication syndrome.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Neurology (D.M., B.S., R.S., D.G., V.N.P., A.M.G.) and Pediatrics (R.S., D.G.), Baylor College of Medicine, Houston, TX.

Objective: We characterized the epilepsy features and contribution to cognitive regression in 47 patients with duplication syndrome (MDS) and reviewed these characteristics in over 280 MDS published cases.

Methods: The institutional review board approved this retrospective review of medical records and case histories of patients with MDS.

Results: The average age at enrollment was 10 ± 7 years. Read More

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December 2018

Reasons to stop drinking alcohol among patients with rheumatoid arthritis in Sweden: a mixed-methods study.

BMJ Open 2018 Dec 14;8(12):e024367. Epub 2018 Dec 14.

Spenshult Research and Development Center, Spenshult, Halmstad, Sweden.

Objectives: The aims were to identify patients with rheumatoid arthritis (RA) who had stopped drinking alcohol and compare them with patients drinking alcohol, and to explore reasons for stopping drinking alcohol.

Design: A sequential explanatory mixed methods design was used.

Setting: Six rheumatology clinics in Southern Sweden Better Anti-Rheumatic FarmacOTherapy cohort. Read More

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December 2018

Neighbourhood characteristics and cumulative biological risk: evidence from the Jamaica Health and Lifestyle Survey 2008: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e021952. Epub 2018 Dec 14.

Department of Global Community Health and Behavioral Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.

Objective: To examine whether neighbourhood characteristics are associated with cumulative biological risk (CBR) and sex differences in CBR in a nationally representative sample in Jamaica, a small island developing country with increasing prevalence of non-communicable diseases (NCDs).

Design: Cross-sectional study SETTING: A population-based cross-sectional survey, the Jamaica Health and Lifestyle Survey 2008 (JHLS II) recruited persons at their homes over a 4 month period from all 14 parishes and 113 neighbourhoods defined as enumeration districts (EDs).

Participants: 2544 persons aged 15-74 years old from the 2008 Jamaica Health and Lifestyle Survey (JHLS II), who completed interviewer-administered questionnaires and had biomarkers assessed, and whose home addresses could be reliably geocoded. Read More

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December 2018

ICF Generic Set as new standard for the system wide assessment of functioning in China: a multicentre prospective study on metric properties and responsiveness applying item response theory.

BMJ Open 2018 Dec 14;8(12):e021696. Epub 2018 Dec 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Objectives: To examine metric properties and responsiveness of the International Classification of Functioning, Disability and Health (ICF) Generic Set when used in routine clinical practice to assess functioning.

Design: Prospective multicentre study.

Setting: 50 hospitals from 20 provinces of Mainland China. Read More

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December 2018
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Vacuolar phosphate transporters contribute to systemic phosphate homeostasis vital for reproductive development in Arabidopsis.

Plant Physiol 2018 Dec 14. Epub 2018 Dec 14.

University of California CITY: Berkeley STATE: California POSTAL_CODE: 94720 United States Of America [US]

Vacuolar storage of phosphate (Pi) is essential for Pi homeostasis in plants. Recent studies have identified a family of vacuolar Pi transporters, VPTs (PHT5s), responsible for vacuolar sequestration of Pi. We report here that both VPT1 and VPT3 contribute to cytosol-to-vacuole Pi partitioning. Read More

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December 2018

Characterizing Activity and Thermostability of GH5 Endoglucanase Chimeras from Mesophilic and Thermophilic Parents.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

From the Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, People's Republic of China

Cellulases from glycoside hydrolase (GH) family 5 are key endoglucanase enzymes in the degradation of diverse polysaccharide substrates and are used in industrial enzyme cocktails to break down biomass. The GH5 family shares a canonical (βα)-barrel structure, where each (βα) module is essential for the enzyme stability and activity. Despite their shared topology, the thermostability of GH5 endoglucanase enzymes can vary significantly, and highly thermostable variants are often sought for industrial applications. Read More

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December 2018
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