1,167,516 results match your criteria Family & Community Health [Journal]


Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation.

Redox Biol 2019 Feb 6;22:101137. Epub 2019 Feb 6.

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, United States. Electronic address:

Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the underlying mechanism using an inducible SMC-MAPK14 knockout mouse line (iSMC-MAPK14). Read More

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http://dx.doi.org/10.1016/j.redox.2019.101137DOI Listing
February 2019

Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.

Int J Drug Policy 2019 Feb 13;67:1-8. Epub 2019 Feb 13.

Children and Family Research Center, National Taiwan University, Taipei, Taiwan.

Aims: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan.

Method: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013. The generalized linear mixed models with negative binomial and logit distributions were performed to evaluate the relationship between individual sociodemographic, health, and addiction treatment characteristics with the number of prenatal visits and receiving prenatal care in the first trimester (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193003
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http://dx.doi.org/10.1016/j.drugpo.2019.01.024DOI Listing
February 2019
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Force-induced decline of TEA domain family member 1 contributes to osteoclastogenesis via regulation of Osteoprotegerin.

Arch Oral Biol 2019 Jan 31;100:23-32. Epub 2019 Jan 31.

Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China. Electronic address:

Objective: This study aims to investigate the responsiveness of transcription factor TEA domain family member 1 (TEAD1) to mechanical force and its impact on osteoclastogenesis as well as expression of Osteoprotegerin (OPG), an inhibitor for osteoclastogenesis playing crucial roles in mechanical stress-induced bone remodeling and orthodontic tooth movement (OTM).

Methods: We first analyzed the correlation between several transcription factors and OPG expression in human periodontal ligament cells (PDLCs). Then dynamic expression changes of TEAD1 with force application were analyzed due to its high correlation with OPG. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.01.020DOI Listing
January 2019

S. epidermidis strains from artisanal cheese made from unpasteurized milk in Poland - Genetic characterization of antimicrobial resistance and virulence determinants.

Int J Food Microbiol 2019 Feb 7;294:55-59. Epub 2019 Feb 7.

Chair of Industrial and Food Microbiology, Faculty of Food Science, University of Warmia and Mazury, Plac Cieszyński 1, 10-726 Olsztyn, Poland.

In Poland artisanal cheese production is an important local economic activity. Artisanal cheese is usually produced using raw cow's milk, animal rennet and salt, without the addition of starter cultures. Coagulase negative staphylococci (CoNS) are often present in artisanal cheeses. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.02.004DOI Listing
February 2019

Maternal employment and child health in Nepal: The importance of job type and timing across the child's first five years.

Soc Sci Med 2019 Feb 6;224:94-105. Epub 2019 Feb 6.

Population Studies Center, University of Michigan, 426 Thompson Street, P.O. Box 1248, Ann Arbor, MI, 48106-1248, USA; Institute for Social and Environmental Research Nepal, Bharatpur Metropolitan City, Ward No. 15, Chitwan, Nepal. Electronic address:

The increase in female labor force participation (FLFP) in the paid labor market since the mid-1900s is one of the most pronounced family transitions and increasingly a global phenomenon. While this may improve income and bargaining power of the women, it may also increase stress and decrease time with children. Using the Chitwan Valley Family Study in Nepal, we explore the consequences of this transition for children's health by combining newly collected data on child health outcomes, quarterly data on women's employment, and data on households and neighborhoods. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.02.009DOI Listing
February 2019

Depression is associated with diabetes status of family members: NHANES (1999-2016).

J Affect Disord 2019 Feb 6;249:121-126. Epub 2019 Feb 6.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Background: The majority of the studies in this area focus on the psychological impact of having diabetic children or adolescents on parents, while a limited number of studies have investigated the effect of diabetes on the mental health status of family members in the general population. Thus, the aim of the current study is to explore the possible association between mental health disorders (depression, anxiety and panic) and diabetes status of family members among a national sample of adults in the United States.

Methods: Our analysis included 1,787 and 25,574 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2016, respectively. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.019DOI Listing
February 2019

'Poetry in motion' a place in the classroom: Using poetry to develop writing confidence and reflective skills.

Nurse Educ Today 2019 Feb 6;76:73-77. Epub 2019 Feb 6.

University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Background: Non-traditional students entering nursing programmes at university often experience difficulties with the academic literacy requirements of their courses, in particular academic and reflective writing. Levels of student anxiety may also be affected by other issues including the pressures of managing work, family and study commitments.

Objectives: To explore how classroom-based poetry writing activities might support students in developing their skills as student-writers and reflective practitioners. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.026DOI Listing
February 2019

Molecular phylogenetics and species delimitation in annual species of Hydrocotyle (Araliaceae) from South Western Australia.

Authors:
Andrew J Perkins

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Western Australian Herbarium, Biodiversity and Conservation Science, Department of Biodiversity, Conservation and Attractions, Locked Bag 104, Bentley Delivery Centre, Western Australia 6983. Electronic address:

Hydrocotyle L. is a cosmopolitan genus, with approximately 150 species, of mostly perennial herbs in the family Araliaceae. The genus includes around 115 perennial and 35 annual species, with all annual species endemic to Australia. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.011DOI Listing
February 2019

Perceptions of Canadian vascular surgeons toward pharmacologic risk reduction in patients with peripheral artery disease: 2018 update.

Ann Vasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada; Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; King Saud University-Li Ka Shing Collaborative Research Program, Toronto, Ontario, Canada; and Riyadh, Kingdom of Saudi Arabia. Electronic address:

Background: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group.

Methods: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.034DOI Listing
February 2019

Variability in survival and post-cardiac arrest care following successful resuscitation from out-of-hospital cardiac arrest.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Aim Of The Study: Regionalization of care for out-of-hospital cardiac arrests (OHCA) may improve patient outcomes. We evaluated inter-hospital variations in post-arrest care provision and the relation between hospital case volume and survival in Pennsylvania.

Methods: This retrospective study (2013-2017) used data from adult OHCA cases in Pennsylvania from the Cardiac Arrest Registry to Enhance Survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.004DOI Listing
February 2019

A modified Delphi and cross-sectional survey to facilitate selection of optimal outcomes and measures for a systematic review on geriatrician-led care models.

J Clin Epidemiol 2019 Feb 13. Epub 2019 Feb 13.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario; Division of Geriatric Medicine, Department of Medicine, University of Toronto, Ontario. Electronic address:

Objective: To identify relevant outcomes and measures to inform a systematic review (SR) on the comparative effectiveness of geriatrician-led care models.

Study Design And Setting: In the modified Delphi to select outcomes for inclusion in the SR, knowledge users (KU) from Ontario, Alberta and Saskatchewan rated outcome importance using a Likert scale. A survey was then completed by geriatricians to determine optimal measures for selected outcomes. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2019.02.005DOI Listing
February 2019

BAG3 deletion suppresses stem cell-like features of pancreatic ductal adenocarcinoma via translational suppression of ISG15.

Biochim Biophys Acta Mol Cell Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry & Molecular Biology, China Medical University, Shenyang 110122, China; Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China. Electronic address:

BAG3 is a member of the cochaperone BAG family and often highly expressed in various cancers. Recently, evidences show that BAG3 promotes stemness of human cancer cells. IFN-stimulated genes 15 (ISG15) is an ubiquitin-like molecule, which is covalently conjugated with substrates to form ISGylated proteins. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.008DOI Listing
February 2019

DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes.

Biochim Biophys Acta Mol Cell Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, Jiangsu 215123, China. Electronic address:

DENN (differentially expressed in normal cells and neoplasia) domain-containing proteins are a family of guanine nucleotide exchange factors (GEFs) for Rab small GTPases and coordinate a plethora of intracellular membrane trafficking events. FAM45A is a non-classical DENN domain protein, whose function was unknown. In this study, we characterized cellular roles of FAM45A. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.006DOI Listing
February 2019

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Monash Institute of Pharmaceutical Sciences, and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia; Columbia University College of Physicians and Surgeons, Columbia University in the City of New York, 21 Audubon Avenue, Rm 209, New York City, NY 10032, USA. Electronic address:

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.266DOI Listing
February 2019

Identification and correction of restrictive strabismus following pterygium excision surgery.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA. Electronic address:

Purpose: To report the characteristics of patients with restrictive diplopia following pterygium excision and a successful treatment approach for the strabismus.

Design: Retrospective interventional case series.

Methods Setting: Single academic institution. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.004DOI Listing
February 2019

Eph/ephrin signalling in the development and function of the mammalian cochlea.

Authors:
Jean Defourny

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

GIGA-Neurosciences, Unit of Cell and Tissue Biology, University of Liège, C.H.U. B36, B-4000, Liège, Belgium. Electronic address:

In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.004DOI Listing
February 2019

Hematology reference intervals for transgender adults on stable hormone therapy.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.

Background: The complete blood count (CBC) is a cornerstone of patient care. Several of the normal values for the components of the CBC differ by sex and, therefore, male-specific and female-specific reference intervals are required to interpret these laboratory results. Transgender individuals are often prescribed hormone therapy to affirm their gender, with resulting serum hormone concentrations similar to those of cisgender individuals. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.011DOI Listing
February 2019

Study of contraceptive Mobile app fails to provide convincing findings.

Contraception 2019 Feb 13. Epub 2019 Feb 13.

green-ivf, Grevenbroich Endocrinology and IVF-Center & Department of Gynecology and Obstetrics University of Cologne (Director: Prof. Dr. Peter Mallmann).

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http://dx.doi.org/10.1016/j.contraception.2018.07.141DOI Listing
February 2019

First report of family clusters of Chagas disease seropositive blood donors in Mexico City and their epidemiological relevance.

Acta Trop 2019 Feb 13. Epub 2019 Feb 13.

Hospital de Infectología, Centro Médico "La Raza", Instituto Mexicano del Seguro Social, Mexico.

Background: Chagas disease is an important health problem in Latin America. Relatives of T. cruzi seropositive donors could also test positive in serological assays. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.014DOI Listing
February 2019

Within-Couple Configuration of Gender-Related Attitudes and its Association with Marital Satisfaction in Chinese Marriage: A Dyadic, Pattern-Analytic Approach.

J Pers 2019 Feb 16. Epub 2019 Feb 16.

Human Development and Family Studies, The University of North Carolina at Greensboro.

Objective: This study seeks to understand the ways in which spouses' gender-related attitudes are configured within couples and how such configurations are linked to marital satisfaction in Chinese marriage.

Method: Latent profile analysis was conducted using dyadic data from a nationwide large sample of Chinese couples from the China Family Panel Studies (CFPS) (N = 7,257 couples; M = 28.36, SD = 12. Read More

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http://dx.doi.org/10.1111/jopy.12467DOI Listing
February 2019

Child, Mother, Father, and Teacher Beliefs About Child Academic Competence: Predicting Math and Reading Performance in European American Adolescents.

J Res Adolesc 2019 Feb 16. Epub 2019 Feb 16.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service.

Beliefs about child competence in math and reading have important implications for academic performance in adolescence. However, it is unclear whether children's own beliefs are the most important predictor of their academic performance or whether parents' and teachers' beliefs about child competence influence child academic performance. We assessed mothers', fathers', teachers', and children's beliefs about European American children's (N = 189) competence in math and reading at age 10 and children's math and language performance at ages 10, 13, and 18 years. Read More

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http://dx.doi.org/10.1111/jora.12477DOI Listing
February 2019

Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.

Int J Cancer 2019 Feb 16. Epub 2019 Feb 16.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, Victoria 3010, Australia.

Our aim was to estimate how long-term mortality following breast cancer diagnosis depends on age at diagnosis, tumor estrogen receptor (ER) status, and the time already survived. We used the population-based Australian Breast Cancer Family Study which followed-up 1,196 women enrolled during 1992-99 when aged <60 years at diagnosis with a first primary invasive breast cancer, over-sampled for younger ages at diagnosis, for whom tumor pathology features and ER status were measured. There were 375 deaths (median follow-up=15. Read More

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http://doi.wiley.com/10.1002/ijc.32214
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http://dx.doi.org/10.1002/ijc.32214DOI Listing
February 2019
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Understanding Skin Screening Practices Among Children at Elevated Risk for Melanoma to Inform Interventions for Melanoma Prevention and Control.

J Cancer Educ 2019 Feb 15. Epub 2019 Feb 15.

Huntsman Cancer Institute, 2000 Circle of Hope, Rm 4509, Salt Lake City, UT, 84112, USA.

Melanoma is the deadliest form of skin cancer. Screening can aid in early disease detection, when treatment is more effective. Although there are currently no consensus guidelines regarding skin screening for pediatric populations with elevated familial risk for melanoma, at-risk children with the help of their parents and healthcare providers may implement skin self-exams. Read More

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http://dx.doi.org/10.1007/s13187-019-01489-3DOI Listing
February 2019

Prevalence and Correlates of Injecting with Visitors from the United States Among People Who Inject Drugs in Tijuana, Mexico.

J Immigr Minor Health 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, MC-0725, La Jolla, CA, 92093-0725, USA.

Cross-border infectious disease transmission is a concern related to drug tourism from the U.S. to Mexico. Read More

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http://dx.doi.org/10.1007/s10903-019-00868-8DOI Listing
February 2019

Mozambique's Community Antiretroviral Therapy Support Group Program: The Role of Social Relationships in Facilitating HIV/AIDS Treatment Retention.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

The Lewis Family Foundation, Boston, MA, USA.

The Community Antiretroviral (ARV) Therapy Support Group (CASG) program aims to address low retention rates in Mozambique's HIV treatment program and the absorptive capacity of the country's health facilities. CASG provides patients with the opportunity to form groups, whose members provide peer support and collect ARV medications on a rotating basis for one another. Based on the promising results in one province, a multi-site level evaluation followed. Read More

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http://dx.doi.org/10.1007/s10461-019-02419-6DOI Listing
February 2019

Effects of a Short Message Service (SMS) Intervention on Reduction of HIV Risk Behaviours and Improving HIV Testing Rates Among Populations located near Roadside Wellness Clinics: A Cluster Randomised Controlled Trial in South Africa, Zimbabwe and Mozambique.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

Department of Economics, University of Gothenburg, Gothenburg, Sweden.

Short Message Service (SMS) offers an innovative method of promoting sexual health to key and vulnerable populations who are users of mobile phones and are at high risk of HIV infection. This cluster randomised control trial tests the effectiveness of a SMS intervention in reducing HIV risk behaviours and improving HIV testing behaviours among truck drivers, sex workers and community residents located near Roadside Wellness Clinics (RWCs) in three southern African countries. The SMS arm received 35 HIV risk reduction and HIV testing SMSs over a 6-month period. Read More

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http://dx.doi.org/10.1007/s10461-019-02427-6DOI Listing
February 2019

Peer Acceptance and Sexual Behaviors from Adolescence to Young Adulthood.

J Youth Adolesc 2019 Feb 15. Epub 2019 Feb 15.

Department of Human Development and Family Studies, University of Connecticut, 348 Mansfield Road, U-1058, Storrs, CT, 06269, USA.

Well-liked adolescents are more likely than their peers to engage in sexual behaviors, which may place them at higher risk of negative outcomes such as sexually transmitted infections and unwanted pregnancy. Yet, little is known regarding whether peer acceptance in adolescence predicts sexual outcomes in young adulthood. Understanding developmental links between peer acceptance and sexual outcomes will inform theories of how peers affect health and can help identify targets for health promotion efforts. Read More

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http://dx.doi.org/10.1007/s10964-019-00991-7DOI Listing
February 2019

Validation of a health screening questionnaire for primary care using Rasch models.

J Patient Rep Outcomes 2019 Feb 15;3(1):12. Epub 2019 Feb 15.

Centre of Research and Education in General Practice, University of Copenhagen, Copenhagen, Denmark.

Background: Health inequality is on the rise due to various social and individual factors. While preventive health checks (PHC) aim to counteract health inequality, there is robust evidence against the use of PHC in general practice. It is unknown which factors can identify persons who will benefit from preventive interventions that are more beneficial than harmful. Read More

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http://dx.doi.org/10.1186/s41687-019-0104-7DOI Listing
February 2019

The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatric Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK.

Objectives: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety. Read More

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http://dx.doi.org/10.1007/s00381-019-04078-3DOI Listing
February 2019

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer.

Cancer Immunol Immunother 2019 Feb 15. Epub 2019 Feb 15.

CureVac AG, Tübingen, Germany.

CV9201 is an RNActive-based cancer immunotherapy encoding five non-small cell lung cancer-antigens: New York esophageal squamous cell carcinoma-1, melanoma antigen family C1/C2, survivin, and trophoblast glycoprotein. In a phase I/IIa dose-escalation trial, 46 patients with locally advanced (n = 7) or metastatic (n = 39) NSCLC and at least stable disease after first-line treatment received five intradermal CV9201 injections (400-1600 µg of mRNA). The primary objective of the trial was to assess safety. Read More

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http://dx.doi.org/10.1007/s00262-019-02315-xDOI Listing
February 2019

Genome-wide identification, characterization, interaction network and expression profile of GRAS gene family in sweet orange (Citrus sinensis).

Sci Rep 2019 Feb 15;9(1):2156. Epub 2019 Feb 15.

College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

GRAS genes are suggested to be grouped into plant-specific transcriptional regulatory families that have been reported to participate in multiple processes, including plant development, phytohormone signaling, the formation of symbiotic relationships, and response to environmental signals. GRAS genes have been characterized in a number of plant species, but little is known about this gene family in Citrus sinensis. In this study, we identified a total of 50 GRAS genes and characterized the gene structures, conserved motifs, genome localizations and cis-elements within their promoter regions. Read More

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http://www.nature.com/articles/s41598-018-38185-z
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http://dx.doi.org/10.1038/s41598-018-38185-zDOI Listing
February 2019
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A novel variant of the human mitochondrial DnaJ protein, Tid1, associates with a human disease exhibiting developmental delay and polyneuropathy.

Eur J Hum Genet 2019 Feb 15. Epub 2019 Feb 15.

School of Neurobiology Biochemistry and Biophysics, Sagol School of Neurosciences, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Here, we describe a single patient from a consanguineous family, who suffers from developmental delay, intellectual disability, hypermetropia, moderate alternating esotropia, unsteady gait, and peripheral polyneuropathy. Brain MRI revealed basal ganglia disease. Exome analysis disclosed a homozygous variant, c. Read More

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http://dx.doi.org/10.1038/s41431-019-0358-9DOI Listing
February 2019

MapB, the Brucella suis TamB homologue, is involved in cell envelope biogenesis, cell division and virulence.

Sci Rep 2019 Feb 15;9(1):2158. Epub 2019 Feb 15.

Fundación Instituto Leloir, IIBBA-CONICET. Patricias Argentinas 435, (C1405BWE), Buenos Aires, Argentina.

Brucella species are Gram-negative, facultative intracellular pathogens responsible for a worldwide zoonosis. The envelope of Brucella exhibits unique characteristics that make these bacteria furtive pathogens and resistant to several host defence compounds. We have identified a Brucella suis gene (mapB) that appeared to be crucial for cell envelope integrity. Read More

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http://www.nature.com/articles/s41598-018-37668-3
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http://dx.doi.org/10.1038/s41598-018-37668-3DOI Listing
February 2019
1 Read

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels.

Nat Commun 2019 Feb 15;10(1):787. Epub 2019 Feb 15.

Institut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U1217, Lyon, 69008, France.

Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here, we reveal the conserved role played by a single amino acid position (TM2.6) located in the second transmembrane domain of two-pore domain potassium (K2P) channels. Read More

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http://dx.doi.org/10.1038/s41467-019-08710-3DOI Listing
February 2019

Novel familial distal imprinting centre 1 (11p15.5) deletion provides further insights in imprinting regulation.

Clin Epigenetics 2019 Feb 15;11(1):30. Epub 2019 Feb 15.

Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, D-52074, Aachen, Germany.

Background: Deletions of the imprinting centre 1 (IC1) in 11p15.5 are rare and their clinical significance is not only influenced by their parental origin but also by their exact genomic localization. In case the maternal IC1 allele is affected, the deletion is associated with the overgrowth disorder Beckwith-Wiedemann syndrome (BWS) and a gain of methylation (GOM) of the IC1. Read More

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http://dx.doi.org/10.1186/s13148-019-0629-xDOI Listing
February 2019

Acceptability and feasibility of a 12-week yoga vs. educational film program for the management of restless legs syndrome (RLS): study protocol for a randomized controlled trial.

Trials 2019 Feb 15;20(1):134. Epub 2019 Feb 15.

Department of Epidemiology, West Virginia University School of Public Health, HSC N, PO Box 9190, Morgantown, WV, 26506, USA.

Background: Restless legs syndrome (RLS) is a common and burdensome sleep disorder associated with profound impairment of health, well-being, and quality of life. Unfortunately, the medications used for RLS management carry risk of serious side effects, including augmentation of symptoms. Yoga, an ancient mind-body discipline designed to promote physical, emotional, and mental well-being, may offer a viable, low-risk new treatment. Read More

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http://dx.doi.org/10.1186/s13063-019-3217-7DOI Listing
February 2019

Reproductive health services utilization and its associated factors among secondary school youths in Woreta town, South Gondar, North West Ethiopia: a cross sectional study.

BMC Res Notes 2019 Feb 15;12(1):90. Epub 2019 Feb 15.

Department of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: The aim of this study was to assess reproductive health service utilization and its associated factors among secondary school students in Woreta town, South Gondar, North east Ethiopia 2018.

Result: Out of the total 376 selected students, 345 were participated in the study with a response rate of 94%. Of these respondents, 85 (24. Read More

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http://dx.doi.org/10.1186/s13104-019-4129-zDOI Listing
February 2019

A systematic review of multi-level stigma interventions: state of the science and future directions.

BMC Med 2019 Feb 15;17(1):41. Epub 2019 Feb 15.

Department of Health Behavior, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

Background: Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural levels. While existing interventions have produced modest reductions in stigma, their full reach and impact remain limited by a nearly exclusive focus targeting only one level of analysis.

Methods: We conducted the first systematic review of original research on multi-level stigma-reduction interventions. Read More

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http://dx.doi.org/10.1186/s12916-018-1244-yDOI Listing
February 2019

Comparison of Trihelix transcription factors between wheat and Brachypodium distachyon at genome-wide.

BMC Genomics 2019 Feb 15;20(1):142. Epub 2019 Feb 15.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling, 712000, China.

Background: Plant Trihelix transcription factors, specifically bind to GT elements and play important roles in plant physiology and development. Wheat is a main cereal crop. Brachypodium distachyon is a close relative of wheat and has been described as a new model species for studying of grass functional genomics. Read More

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http://dx.doi.org/10.1186/s12864-019-5494-7DOI Listing
February 2019

Epidemiological investigation and phylogenetic analysis of Caprine parainfluenza virus type 3 in sheep of China.

Transbound Emerg Dis 2019 Feb 16. Epub 2019 Feb 16.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, China, Academy of Agricultural Sciences, Lanzhou, 730046, China.

Caprine parainfluenza virus type 3 (CPIV3) is a new member of the Respirovirus genus in the Paramyxivirudae family, mainly causing respiratory disease. Up to now, accumulating evidence has focused on CPIV3 infection in goats, with little understood about its epidemiology in sheep. To that end, we collected 1163 sheep sera samples from 9 provinces/autonomous regions in 2012 and 1863 samples from 6 provinces/autonomous regions during 2016-2017, with serological prevalence of 50. Read More

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http://doi.wiley.com/10.1111/tbed.13149
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http://dx.doi.org/10.1111/tbed.13149DOI Listing
February 2019
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Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopedics, Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Ligustilide (LIG) is the main lipophilic component of the Umbelliferae family of pharmaceutical plants, including Radix angelicae sinensis and Ligusticum chuanxiong. LIG shows various pharmacological properties associated with anti-inflammation and anti-apoptosis in several kinds of cell lines. However, the therapeutic effects of LIG on chondrocyte apoptosis remain unknown. Read More

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http://dx.doi.org/10.1111/jcmm.14226DOI Listing
February 2019

A commentary on population genetic testing for primary prevention: changing landscape and the need to change paradigm.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

Barts Cancer Institute, Queen Mary University of London, Old Anatomy Building, Charterhouse Square, London, EC1M 6BQ, UK.

BRCA1/BRCA2 genes were discovered in early 1990s and clinical testing for these has been available since the mid-1990s. National Institute of Health and Care Excellence (NICE) and other international guidelines recommend genetic-testing at a ~10% probability threshold of carrying a BRCA-mutation. A detailed three generation family-history (FH) of cancer is used within complex mathematical models (e. Read More

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http://dx.doi.org/10.1111/1471-0528.15657DOI Listing
February 2019

Single kidney transplantation from donors with acute kidney injury: A single-center experience.

Pediatr Transplant 2019 Feb 15:e13326. Epub 2019 Feb 15.

Department of Urology, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors.

Methods: We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non-AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes.

Results: AKI was defined and staging by the RIFLE criteria and pediatric-modified RIFLE criteria. Read More

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http://dx.doi.org/10.1111/petr.13326DOI Listing
February 2019

8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Hematology Malignancies and Stem Cell Transplantation Institute, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, California.

Nucleoside analogs represent the backbone of several distinct chemotherapy regimens for acute myeloid leukemia (AML) and combination with tyrosine kinase inhibitors has improved survival of AML patients, including those harboring the poor-risk FLT3-ITD mutation. Although these compounds are effective in killing proliferating blasts, they lack activity against quiescent leukemia stem cells (LSCs), which contributes to initial treatment refractoriness or subsequent disease relapse. The reagent 8-chloro-adenosine (8-Cl-Ado) is a ribose-containing, RNA-directed nucleoside analog that is incorporated into newly transcribed RNA rather than in DNA, causing inhibition of RNA transcription. Read More

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http://dx.doi.org/10.1002/jcp.28294DOI Listing
February 2019

A Telehealth-Enhanced Referral Process in Pediatric Primary Care: A Cluster Randomized Trial.

Pediatrics 2019 Feb 15. Epub 2019 Feb 15.

Center for Health Services and Society, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.

: media-1vid110.1542/5984243450001PEDS-VA_2018-2738 OBJECTIVES: To improve the mental health (MH) referral process for children referred from primary care to community mental health clinics (CMHCs) by using a community-partnered approach.

Methods: Our partners were a multisite federally qualified health center and 2 CMHCs in Los Angeles County. Read More

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http://dx.doi.org/10.1542/peds.2018-2738DOI Listing
February 2019

Patient Perspectives on DMARD Safety Concerns in Rheumatology Trials: Results from Inflammatory Arthritis Patient Focus Groups and OMERACT Attendees Discussion.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Family Medicine, McGill University, Montreal, Canada. Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. Canberra Rheumatology, Canberra, ACT, Australia College of Health and Medicine, Australian National University, Canberra, ACT, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia. Patient Partners, Ingersoll, Canada. Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA; Department Social Work Programs, Hospital for Special Surgery, New York, NY USA; Department Social Work Programs, Hospital for Special Surgery, New York, NY USA; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Institute of Bone and Joint Research-Kolling Institute, University of Sydney; Rheumatology Department, Royal North Shore Hospital; Centre for Health Policy, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Northern Health, Epping Victoria. Sydney Medical School, University of Sydney, Sydney, Australia; Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia; Department of Rheumatology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, 2065, Australia. Clinical Investigator, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada; Adjunct Professor, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa; Professor of Biostatistics and Clinical Epidemiology; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; & Department of Rheumatology, Odense University Hospital, Denmark.Professor, Department of Medicine, McGill University, Montreal, Quebec, Canada Adjunct Professor, Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Address correspondence to Dr. Susan J. Bartlett. Email:

Objective: The OMERACT Safety Working Group is identifying core safety domains that matter most to rheumatic disease patients.

Methods: International focus groups were held with 39 inflammatory arthritis patients to identify DMARD experiences and concerns. Themes were identified by pragmatic thematic coding and discussed in small groups by meeting attendees. Read More

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http://dx.doi.org/10.3899/jrheum.181185DOI Listing
February 2019

Advancing stiffness measurement in rheumatic disease: report from the Stiffness Special Interest group at OMERACT 2018.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From Johns Hopkins University School of Medicine, Baltimore, MD USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; McGill University, Montreal, Quebec, Canada; Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA; Division of Medicine, The University of Adelaide, Adelaide, Australia Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia; Horizon Pharma, Inc, Lake Forest, Illinois, USA and Adjunct Professor, College of Pharmacy, University of Illinois, Chicago, IL, USA; Healthy Motivation, Bone and Joint Decade Global Alliance for Musculoskeletal Health, Santa Barbara, California, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Singapore General Hospital, Duke-NUS Medical School; University of Bristol, Bristol, UK; University of West England - Bristol, Bristol, UK. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. Work from the US Cohort was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award numbers [P30-AR070254 Core B] and [P30-AR053503 Core D] and Patient Centered Outcomes Research Institute (PCORI) Pilot Project Award number [IP2-PI000737], and the Camille Julia Morgan Arthritis Research and Education Fund. All statements in this report including its conclusions are the opinions of the authors and do not necessarily reflect those of PCORI, its board of governors, or its methodology committee, or of NIH or NIAMS. RH is an employee of Horizon Pharma, LLC; CK is an employee of Janssen Scientific Affairs, LLC. Address correspondence to Ethan T Craig, 3900 Woodland Ave., Philadelphia, PA 19104. Email:

Objective: To improve measurement of stiffness in rheumatic disease.

Methods: Data presented included: 1) Two qualitative projects; 2) The RA Stiffness patient-reported outcome measure (RAST); 3) three items assessing stiffness severity, duration, and interference. 3) RESULTS: Stiffness is multidimensional and includes aspects of stiffness experience such as duration, severity, and impact. Read More

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http://dx.doi.org/10.3899/jrheum.181074DOI Listing
February 2019

Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.

J Biol Chem 2019 Feb 15. Epub 2019 Feb 15.

University of Vermont, United States.

The kinesin-3 family member KIF1A plays a critical role in site-specific neuronal cargo delivery during axonal transport. KIF1A cargo is mislocalized in many neurodegenerative diseases, indicating that KIF1A's highly efficient, superprocessive motility along axonal microtubules needs to be tightly regulated. One potential regulatory mechanism may be through posttranslational modifications (PTMs) of axonal microtubules. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005765DOI Listing
February 2019

The malate-activated ALMT12 anion channel in the grass is co-activated by Ca/calmodulin.

J Biol Chem 2019 Feb 15. Epub 2019 Feb 15.

University of Saskatchewan, Canada.

In plants, strict regulation of stomatal pores is critical for modulation of CO fixation and transpiration. Under certain abiotic and biotic stressors, pore closure is initiated through anionic flux, with calcium (Ca), playing a central role. The aluminum-activated malate transporter 12 (ALMT12) is a malate-activated, voltage-dependent member of the aluminum-activated malate transporter family, implicated in anionic flux from guard cells controlling stomatal aperture. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005301DOI Listing
February 2019

A Family of NAI2-Interacting Proteins in the Biogenesis of the ER Body and Related Structures.

Plant Physiol 2019 Feb 15. Epub 2019 Feb 15.

Purdue University Department of Botany and Plant Pathology, Purdue University, 915 W. State Street CITY: West Lafayette POSTAL_CODE: 47907-2054 United States Of America [US]

Plants produce different types of endoplasmic reticulum (ER)-derived vesicles that accumulate and transport proteins, lipids, and metabolites. In the Brassicales, a distinct ER-derived structure called the ER body is found throughout the epidermis of cotyledons, hypocotyls, and roots. NAI2 is a key factor for ER body formation in Arabidopsis (Arabidopsis thaliana). Read More

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http://dx.doi.org/10.1104/pp.18.01500DOI Listing
February 2019
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