Search Our Scientific Publications & Authors

Cell Physiol Biochem 2018 11;51(5):2472-2483. Epub 2018 Dec 11.

Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background/aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Read More

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

Child Abuse Negl 2018 Dec 8;88:201-211. Epub 2018 Dec 8.

Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, United States; The Ohio State University College of Medicine, Department of Pediatrics, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, United States. Electronic address:

Background: The majority of youth with problem sexualized behaviors (PSB) have substantiated experiences of abuse or exposures to violence (Silovsky & Niec, 2002). Little is known about specific abuse experiences that may differentiate youth with PSB from those without. Few studies have examined the types of abuse associated with post-traumatic stress symptomology. Read More

J Plant Physiol 2018 Nov 20;232:94-99. Epub 2018 Nov 20.

Institute of Basic Biological Problems of Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

The carrier of carbonic anhydrase (CA) activity was detected in gel among low molecular mass proteins from pea, spinach and Arabidopsis, after nondenaturing electrophoresis in PAAG of the dodecyl-β-d-maltoside treated PSII membranes (the fragments of thylakoid membrane containing PSII complexes). The elimination of Mn-stabilizing protein PsbO by treatment of PSII membranes with salts, did not lead to a decrease in CA activity observed in the gel although it reduced the amount of this protein down to 25% compared to the original sample. The isolated protein PsbO did not demonstrated CA activity. Read More

J Plant Physiol 2018 Nov 16;232:141-150. Epub 2018 Nov 16.

Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou Hainan 571101, China; College of Life Sciences, Key Laboratory for Ecology of Tropical Islands, Ministry of Education, Hainan Normal University, Haikou, Hainan 571158, China. Electronic address:

Sesuvium portulacastrum, an important mangrove-associated true halophyte belongs to the family Aizoaceae, has excellent salt tolerance. Chloroplasts are the most sensitive organelles involved in the response to salinity. However, the regulation mechanism of chloroplasts of S. Read More

Bone 2018 Dec 8. Epub 2018 Dec 8.

Institut für Medizinische Genetik und Humangenetik, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

The osteopetroses and related sclerosing bone dysplasias can have a broad range of manifestations. Especially in the milder forms, sandwich vertebrae are an easily recognizable and reliable radiological hallmark. We report on four patients from three families presenting with sandwich vertebrae and platyspondyly. Read More

Parasitol Int 2018 Dec 8. Epub 2018 Dec 8.

Institute of Aquaculture, University of Stirling, Stirling, UK.

Argulus foliaceus (Linnaeus, 1758) is a member of the branchiuran family Argulidae, a group comprising parasitic "fish lice". A. foliaceus is distributed worldwide and causes major economic impacts for cultured freshwater fish globally. Read More

Appetite 2018 Dec 8. Epub 2018 Dec 8.

Department of Human Ecology, University of California, Davis 1309 Hart Hall, One Shields Avenue, Davis, CA, 95616, USA. Electronic address:

Home-packed lunches have been found to be of lower nutritional quality than school-bought lunches, yet little is known about family-based factors associated with lunch packing. The current exploratory study examines parental and family predictors of fruits and vegetables packed in lunches, hypothesizing parents' nutrition knowledge and authoritative parenting as well as children's involvement in lunch decisions would relate to packing more fruits and vegetables, while financial difficulties would relate to packing fewer. Ninety parent-child dyads from 4th-6th grade participated for 5 consecutive school days. Read More

Cancer Cell 2018 Dec;34(6):922-938.e7

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

Drug resistance represents a major challenge to achieving durable responses to cancer therapeutics. Resistance mechanisms to epigenetically targeted drugs remain largely unexplored. We used bromodomain and extra-terminal domain (BET) inhibition in neuroblastoma as a prototype to model resistance to chromatin modulatory therapeutics. Read More

Hum Fertil (Camb) 2018 Dec 11:1-12. Epub 2018 Dec 11.

b NGA Law and Brilliant Beginnings , London , UK.

This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60). Read More

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Universidad Complutense de Madrid, Facultad de Farmacia, Ciudad Universitaria, 28040, Madrid, SPAIN.

The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoration with targeting moieties able to recognize these cells in a specific manner. Neuroblastoma (NB) is the most frequent extra-cranial pedriatic tumor, almost incurable at advanced stages. Read More

Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Division of Cardiology, UCLA Mattel Children's Hospital, Los Angeles, California.

Objectives: To describe a multi-center experience of percutaneous transcatheter pulmonary valve replacement (TPVR) using the Edwards Sapien S3 Valve.

Background: Off-label use of the Sapien S3 valve can allow for TPVR in patients with congenital heart disease (CHD) and large diameter dysfunctional right ventricular outflow tract (RVOT). The initial experience at five centers with the SAPIEN S3 valve for TPVR is presented with a focus on procedural techniques, success, complications, and efficacy. Read More

Immunol Cell Biol 2018 Dec 9. Epub 2018 Dec 9.

Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia.

Class Ib MHC are an extended family of molecules which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule in that it is overexpressed in the liver but its immunological function is not known. Read More

Genet Epidemiol 2018 Dec 9. Epub 2018 Dec 9.

Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland.

We develop linear mixed models (LMMs) and functional linear mixed models (FLMMs) for gene-based tests of association between a quantitative trait and genetic variants on pedigrees. The effects of a major gene are modeled as a fixed effect, the contributions of polygenes are modeled as a random effect, and the correlations of pedigree members are modeled via inbreeding/kinship coefficients. -statistics and χ likelihood ratio test (LRT) statistics based on the LMMs and FLMMs are constructed to test for association. Read More

Phytother Res 2018 Dec 9. Epub 2018 Dec 9.

The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA.

Protopanaxadiol (PPD), a ginseng metabolite generated by the gut bacteria, was shown to induce colorectal cancer cell death and enhance the anticancer effect of chemotherapeutic agent 5-FU. However, the mechanism by which PPD promotes cancer cell death is not clear. In this manuscript, we showed that PPD activated p53 and endoplasmic reticulum (ER) stress and induced expression of BH3-only proteins Puma and Noxa to promote cell death. Read More

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: The overlying inflammatory mucosa plays a crucial role in the initiation of osteitis; however, the molecular mechanism is unclear. The objective of this study was to explore the bone morphogenetic protein (BMP) pathway and to correlate the expression of key signaling molecules with the degree of osteitis in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Study Design: Prospective experimental analysis. Read More

J Fish Biol 2018 Dec 7. Epub 2018 Dec 7.

University of Hawai'i at Mānoa 2538 McCarthy Mall Edmondson Hall 216 Honolulu, Hawai'I, USA.

This study documents changes in gonadal structure for the serial hermaphrodite (or bidirectional sex changer) divine dwarfgoby Eviota epiphanes (family Gobiidae) as individuals transition in both directions. To evaluate transitional gonad morphology, individuals actively producing the same gamete type (oocytes or sperm) were set up into pairs and euthanised over a period of 14 days to get a time series of morphological changes during gonad transformation. Results from this study show that rapid changes in the gonad take place at a structural level as individuals change their reproductive function and gamete production. Read More

Chemistry 2018 Dec 10. Epub 2018 Dec 10.

Beijing Institute of Technology, 100081, Beijing, CHINA.

The ABX3-type halide perovskite nanocrystals (NCs) have been a hot topic recently due to their fascinating optoelectronic properties. It has been demonstrated that A-site ion has an impact on the photophysical and chemical properties, such as optical bandgap and chemical stability. The pursuit of halide perovskite materials with diversified A-site species would deepen the understanding on the structure-property relationship of the perovskite family. Read More

Br J Haematol 2018 Dec 9. Epub 2018 Dec 9.

Department of Medical Oncology, Dana-Farber Cancer Institute, Cambridge, MA, USA.

The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological malignancies but its role in CLL remains to be fully elucidated. Here, we report that MYD88 L265P mutations are associated with mutated immunoglobulin heavy-chain gene (IGHV-M) status and that among IGHV-M patients, the presence of MYD88 L265P is associated with younger age at diagnosis. Read More

Int J Psychol 2018 Dec 10. Epub 2018 Dec 10.

Bar-Ilan University, Ramat-Gan, Israel.

Using the family stress model as our conceptual framework, we explored whether observed maternal parenting practices (positive and coercive) account for the associations between mothers' post-traumatic stress symptoms and children's externalising behaviours. Mothers' self-reported post-traumatic stress symptoms, observed maternal practices, and reports of children's externalising behaviour were collected from 123 Israeli mothers and their children, who were exposed to ongoing rocket attacks in southern Israel. A structural equation model revealed that mothers' post-traumatic stress symptoms were linked with greater maternal coercive parenting practices, which in turn were associated with more externalising behaviours in children. Read More

Physiol Plant 2018 Dec 8. Epub 2018 Dec 8.

Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 210602, China.

In vascular (Arabidopsis thaliana) and nonvascular (Physcomitrella patens) plants, PHOSPHATE 1 (PHO1) homologs play important roles in the acquisition and transfer of phosphate. The tomato genome contains six genes (SlPHO1;1-SlPHO1;6) homologous to AtPHO1. The six proteins have typical characteristics of the plant PHO1 family, such as the three SPX sub domains in the N-terminal portion and one EXS domain in the C-terminal portion. Read More

J Phycol 2018 Dec 9. Epub 2018 Dec 9.

Department of Biological Sciences, University of Rhode Island, Kingston, Rhode Island, 02879, USA.

Parasitism is a life strategy that has repeatedly evolved within the Florideophyceae. Historically, the terms adelphoparasite and alloparasite have been used to distinguish parasites based on the relative phylogenetic relationship of host and parasite. However, analyses using molecular phylogenetics indicate that nearly all red algal parasites infect within their taxonomic family, and a range of relationships exist between host and parasite. Read More

Hum Brain Mapp 2018 Dec 7. Epub 2018 Dec 7.

MEG and Cortical Networks Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences. Read More

J Surg Oncol 2018 Dec 9. Epub 2018 Dec 9.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background And Objective: To investigate the role of postoperative radiotherapy (PORT) in IIIA-N2 non-small cell lung cancer (NSCLC) patients and subgroups which derived benefit from PORT.

Methods: A total of 576 patients with pathological IIIA-N2 NSCLC, who underwent complete resection, were identified. Propensity score matching (PSM) methods were used to balance the patients' characteristics between two groups. Read More

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Indiana University School of Medicine, Dept. of Biochemistry and Molecular Biology, 635 Barnhill Drive, MS4063, Indianapolis, Indiana.

Ting-Kai (T-K) Li, MD died on November 18, 2018, just five days after his 84 birthday. T-K had a wonderful and distinguished academic and public service career, spanning almost five decades. Born in Nanjing, China, T-K fled with his family to South Africa during World War II, while a young boy. Read More

Evolution 2018 Dec 11. Epub 2018 Dec 11.

Division of Ecology and Evolution, Research School of Biology, The Australian National University, 0200, Canberra, ACT, Australia.

Testing hypotheses on the drivers of clade evolution and trait diversification provides insight into many aspects of evolutionary biology. Often, studies investigate only the intrinsic biological properties of organisms as the causes of diversity, however extrinsic properties of a clade's environment, particularly geological history, may also offer compelling explanations. The Andes are a young mountain chain known to have shaped many aspects of climate and diversity of South America. Read More

Addict Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, University of California San Francisco, San Francisco, California.

Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum (DMS) of rodents, and that Fyn signaling in the DMS contributes to rat alcohol intake and relapse. Here, we used AZD0530, a CNS penetrable inhibitor of Src PTKs developed for the treatment of Alzheimer disease and cancer and tested its efficacy to suppress alcohol-dependent molecular and behavioral effects. Read More

Cochrane Database Syst Rev 2018 Dec 9;12:CD012132. Epub 2018 Dec 9.

School of Medicine, Royal College of Surgeons in Ireland, 121 St. Stephens Green, Dublin, Ireland, 2.

Background: Pressure ulcers, which are a localised injury to the skin, or underlying tissue, or both, occur when people are unable to reposition themselves to relieve pressure on bony prominences. Pressure ulcers are often difficult to heal, painful, expensive to manage and have a negative impact on quality of life. While individual patient safety and quality care stem largely from direct healthcare practitioner-patient interactions, each practitioner-patient wound-care contact may be constrained or enhanced by healthcare organisation of services. Read More

J Intellect Disabil Res 2018 Dec 10. Epub 2018 Dec 10.

Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.

Background: Parenting behaviours influence many domains of child development, and recent work has demonstrated the specific effects of parenting on the development of executive function (EF) abilities. The relationship between parent-child interaction patterns and EF has been examined in typically developing (TD) children but has not yet been examined in dyads where the child has a diagnosis of Down syndrome (DS).

Method: The current study examines the differences in patterns of parenting behaviours between DS dyads and dyads with TD children equated on nonverbal mental age. Read More

J Adv Nurs 2018 Dec 10. Epub 2018 Dec 10.

Capital Medical University, School of Nursing.

Aims: To explore the motivation of family members of patients at high risk for sudden cardiac death for undertaking cardiopulmonary resuscitation (CPR) training.

Background: Home cardiac arrests are associated with poor outcomes because few family members learn CPR. Little is known about factors that motivate family members to participate in CPR training. Read More

J Intellect Disabil Res 2018 Dec 9. Epub 2018 Dec 9.

Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: The association of behavioural phenotype assessment with cytogenomic characterisation may provide a better comprehension of genotype-phenotype correlations in syndromes caused by chromosomal abnormalities, such as 18p deletion syndrome.

Method: We report on four Brazilian patients with 18p deletion syndrome characterised by cytogenomic techniques and detailed neuropsychological evaluation. Intellectual, adaptive and behavioural characteristics were assessed through the Wechsler's Scales, the Vineland-II Scale and the Child Behaviour Checklist, respectively. Read More

Dev Med Child Neurol 2018 Dec 10. Epub 2018 Dec 10.

The Hospital for Sick Children, Toronto, Ontario, Canada.

Aim: To describe the process of obtaining consensus of outcome priorities between families of children with medical complexity (CMC) and their healthcare providers (HCPs) for the purpose of evaluating changes to service delivery.

Method: The consensus of outcomes involved surveying families of CMC and HCPs and an in-person consensus meeting. Priorities were obtained from the survey using a stratified ranking approach ensuring equal representation among unequally sized subgroups. Read More

Fam Process 2018 Dec;57(4):849-854

Family Process and Family Institute at Northwestern, Evanston, IL.

FEBS Lett 2018 Dec 8. Epub 2018 Dec 8.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.

The RNase II family of ribonucleases is ubiquitous and critical for RNA metabolism. The rnb500 allele has been widely used for over 30 years; however, the underlying genetic changes which result in RNase II thermolabile activity remain unknown. Here, we combine molecular and biophysical studies to carry out an in vivo and in vitro investigation of RNase II mutation(s) that confer the rnb500 phenotype. Read More

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.

Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).

Design: Consensus meeting.

Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More

Environ Microbiol 2018 Dec 10. Epub 2018 Dec 10.

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.

Bacterial genes for molybdenum-containing and tungsten-containing enzymes are often differentially regulated depending on the metal availability in the environment. Here, we describe a new family of transcription factors with an unusual DNA-binding domain related to excisionases of bacteriophages. These transcription factors are associated with genes for various molybdate and tungstate-specific transporting systems as well as molybdo/tungsto-enzymes in a wide range of bacterial genomes. Read More

J Bone Miner Res 2018 Dec 7. Epub 2018 Dec 7.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.

The optimal approach to osteoporosis screening and treatment in postmenopausal women is unclear. We compared 1) the United States Preventive Services Task Force (USPSTF) and Osteoporosis Canada osteoporosis screening strategies; and 2) the National Osteoporosis Foundation (NOF) and Canadian treatment strategies. We used data from the prospective Women's Health Initiative Observational Study and Clinical Trials of women aged 50-79 years at baseline (n = 117,707 followed for self-reported fractures; n = 8,134 in bone mineral density [BMD] subset). Read More

Small 2018 Dec 11:e1804133. Epub 2018 Dec 11.

Department of Energy Engineering, School of Energy and Chemical Engineering, Low Dimensional Carbon Materials Center, Perovtronics Research Center, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

The surface property of growth substrate imposes significant influence in the growth behaviors of 2D materials. Rhenium disulfide (ReS ) is a new family of 2D transition metal dichalcogenides with unique distorted 1T crystal structure and thickness-independent direct bandgap. The role of growth substrate is more critical for ReS owing to its weak interlayer coupling property, which leads to preferred growth along the out-of-plane direction while suppressing the uniform in-plane growth. Read More

Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.

Department of Medical Oncology, University Hospital of Parma, Parma, Italy.

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology, University of Vermont, Burlington, VT, 05405.

Key Points Summary: K 7 channels are a family of voltage-dependent K channels expressed in many cell types, which open in response to membrane depolarization to regulate cell excitability. Drugs that target K 7 channels are used clinically to treat epilepsy. Interestingly, these drugs also cause urinary retention, but it was unclear how. Read More

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Institute for Refractory Cancer Research.

Hypermutagenesis refers to marked increase in the number of mutations due to continuous mutagenic process. Hypermutated tumors, have being found in several tumor types, are associated with inherited or acquired alterations in DNA repair pathways. Hypermutation has been observed in a subset of adult glioma patients as a direct result of temozolomide(TMZ)-induced mutagenesis. Read More

Child Dev 2018 Dec 11. Epub 2018 Dec 11.

Norwegian Institute of Public Health and University of Oslo.

Do associations between maternal anxiety symptoms and offspring mental health remain after comparing differentially exposed siblings? Participants were 17,724 offspring siblings and 11,553 mothers from the Norwegian Mother and Child Cohort study. Mothers reported anxiety and depressive symptoms at 30 weeks' gestation, and 0.5, 1. Read More

Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France.

Eomesodermin (Eomes) is a transcription factor (TF) of the T-box family closely related to T-bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T-cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. Read More

J Adv Nurs 2018 Dec 10. Epub 2018 Dec 10.

International Observatory on End of Life Care, Lancaster University, Furness Building, Lancaster, LA1 4YG, UK.

Aim: To increase understanding of grandparental grief following the death of a grandchild from a life-limiting condition.

Design: META-ETHNOGRAPHY: DATA SOURCES: Academic Search Complete (2015, updated 2018), CINHAL, Embase, psycINFO, PubMed and Web of Science, supplemented by manual search strategies.

Review Methods: Studies were appraised and synthesised using the principles of meta-ethnography. Read More

Biomed Chromatogr 2018 Dec 9:e4459. Epub 2018 Dec 9.

National Research Institute for Family Planning, Beijing, China.

This report details the preparation of anastrozole (ATZ) reservoir-type intravaginal ring (IVR) and the detection the concentration of ATZ in Beagle dog plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS). An ATZ reservoir-type IVR which included ATZ silicone elastomer core and non-active silicone layer, was manufactured by reaction injection moulding at 80°C for 20 min. In vitro release experiment was performed under sink conditions and the samples are determined by high performance liquid chromatography (HPLC). Read More

J Bone Miner Res 2018 Dec 10. Epub 2018 Dec 10.

Calcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, Canada.

We review advancing and overlapping stages for our understanding of the expressions of six hyperparathyroid (HPT) syndromes: multiple endocrine neoplasia type 1 (MEN1) or type 4, multiple endocrine neoplasia type 2A (MEN2A), hyperparathyroidism-jaw tumor syndrome, familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated hyperparathyroidism. During stage 1 (1903 to 1967), the introduction of robust measurement of serum calcium was a milestone that uncovered hypercalcemia as the first sign of dysfunction in many HPT subjects, and inheritability was reported in each syndrome. The earliest reports of HPT syndromes were biased toward severe or striking manifestations. Read More

Public Health Nurs 2018 Dec 9. Epub 2018 Dec 9.

Blue Ridge Health, Sylva, North Carolina.

The INPUT project is a model partnership that changed the way health care was offered to the underserved in rural Western North Carolina. Grant funding provided a full-time Family Nurse Practitioner (FNP) to a free clinic and created clinical placements for FNP students. Students had opportunities to learn about unique aspects of care for vulnerable, underserved populations to encourage them to consider working in rural communities. Read More

J Clin Psychol 2018 Dec 8. Epub 2018 Dec 8.

Department of Child Welfare and Studies, Sookmyung Women's University, Seoul, South Korea.

Objective: This study explored parentification dimensions, the age of onset, duration, and family circumstances to better understand the characteristics of parentification and its impact on depressive symptoms among Korean college students.

Method: A sample of South Korean college students (N = 316, aged 18-29 years, 66.1% female) rated their childhood parentification experiences and current depressive symptoms. Read More