10,825 results match your criteria Familial Adenomatous Polyposis


Laparoscopic surgery reduces the incidence of surgical site infections compared to the open approach for colorectal procedures: a meta-analysis.

Tech Coloproctol 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, East Suffolk and North Essex NHS Trust, Colchester, UK.

Background: Surgical site infections (SSI) are the commonest healthcare associated infections. They severely compromise patient safety, are a significant burden on healthcare resources and have an adverse impact on patient quality of life. The incidence of SSIs can be as high as 10% after colorectal procedures. Read More

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http://dx.doi.org/10.1007/s10151-020-02293-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346580PMC

Twenty years of restorative proctocolectomy with ileal pouch anal anastomosis in Beaumont Hospital.

Ir J Med Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.

Introduction: An ileal pouch anal anastomosis (IPAA) is the treatment of choice in selected patients to restore intestinal continuity following proctocolectomy. Data on IPAA in the Republic of Ireland is lacking, and surgery for IPAA has evolved over time. The aim of this retrospective study was to report our institutional outcomes from IPAA over a 20-year period. Read More

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http://dx.doi.org/10.1007/s11845-020-02297-1DOI Listing

Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway.

Clin Sci (Lond) 2020 Jul 7. Epub 2020 Jul 7.

The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Mounting evidence has displayed critical roles of circular RNAs (circRNAs) in multiple cancers. The underlying mechanisms by which circFGD4 contributed to gastric cancer (GC) are still unclear.

Methods: The levels and clinical values of circFGD4 in GC patients were detected and analysed by quantitative real-time PCR. Read More

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http://dx.doi.org/10.1042/CS20191043DOI Listing

A Support Vector Machine Model Predicting the Risk of Duodenal Cancer in Patients with Familial Adenomatous Polyposis at the Transcript Levels.

Biomed Res Int 2020 16;2020:5807295. Epub 2020 Jun 16.

Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Objective: Familial adenomatous polyposis (FAP) is one major type of inherited duodenal cancer. The estimate of duodenal cancer risk in patients with FAP is critical for selecting the optimal treatment strategy.

Methods: Microarray datasets related with FAP were retrieved from the Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.1155/2020/5807295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315318PMC

[Challenges of screening germline predispositions in children].

Authors:
Atsushi Manabe

Rinsho Ketsueki 2020 ;61(6):682-686

Department of Pediatrics, Hokkaido University Graduate School of Medicine.

Genetic predisposition is a major cause of childhood cancer. Multiple cancer-predisposing syndromes have been identified, including Li-Fraumeni syndrome (LFS), neurofibromatosis type 1, APC-related adenomatous polyposis, Beckwith-Wiedemann syndrome, multiple endocrine neoplasia 1, ataxia telangiectasia, RUNX1 deficiency, Fanconi anemia, Bloom syndrome, and PTEN hamartoma tumor syndrome. LFS is a prototypical genetically predisposing condition. Read More

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http://dx.doi.org/10.11406/rinketsu.61.682DOI Listing
January 2020

Recurrent APC splice variant c.835-8A>G in patients with unexplained colorectal polyposis fulfilling the colibactin mutational signature.

Gastroenterology 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.06.055DOI Listing

Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion.

J Cell Biol 2020 Sep;219(9)

Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA.

Cell migration is driven by pushing and pulling activities of the actin cytoskeleton, but migration directionality is largely controlled by microtubules. This function of microtubules is especially critical for neuron navigation. However, the underlying mechanisms are poorly understood. Read More

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http://dx.doi.org/10.1083/jcb.202003091DOI Listing
September 2020

Isoperistaltic Jejunal Loop Interposition after Total Gastrectomy for Gastric Cancer in Patients with Familial Adenomatous Polyposis.

J Gastric Cancer 2020 Jun 13;20(2):225-231. Epub 2020 Apr 13.

Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Clinica Chirurgica I, Azienda Ospedaliera di Padova, Università di Padova, Padova, Italy.

Gastric cancer is a rare condition affecting patients with familial adenomatous polyposis (FAP). The mainstay of treatment is total gastrectomy. Since duodenal cancer is the most common cause of death after total colectomy in FAP, endoscopic surveillance for duodenal cancer is mandatory. Read More

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http://dx.doi.org/10.5230/jgc.2020.20.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311215PMC

Silencing the intestinal GUCY2C tumor suppressor axis requires loss of heterozygosity.

Cancer Biol Ther 2020 Jun 28:1-7. Epub 2020 Jun 28.

Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College at Thomas Jefferson University , Philadelphia, PA, USA.

Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli () tumor suppressor gene, while germline heterozygosity for mutant produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of heterozygosity (LOH) silences the remaining normal allele of , through an unknown mechanism, as the initiating step in transformation. Guanylyl cyclase C receptor (GUCY2C) and its hormones, uroguanylin and guanylin, have emerged as a key signaling axis opposing mutations driving intestinal tumorigenesis. Read More

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http://dx.doi.org/10.1080/15384047.2020.1779005DOI Listing

The genetic factors associated with Wnt signaling pathway in colorectal cancer.

Life Sci 2020 Jun 25:118006. Epub 2020 Jun 25.

Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Colorectal cancer (CRC) is a common cancer with poor prognosis and high mortality. There is growing information about the factors involved in the pathogenesis of CRC. However, the knowledge of the predisposing factors is limited. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118006DOI Listing

Lower Rate of CTNNB1 Mutations and Higher Rate of APC Mutations in Desmoid Fibromatosis of the Breast: A Series of 134 Tumors.

Am J Surg Pathol 2020 Jun 24. Epub 2020 Jun 24.

Departments of Pathology.

Desmoid fibromatosis (DF) is a rare, locally aggressive, nonmetastasizing fibroblastic/myofibroblastic tumor with a tendency to recur and an unpredictable clinical course. A "wait-and-see" policy is the new standard of care. DF are characterized by activating alterations of the wnt/β-catenin pathway: CTNNB1 or adenomatous polyposis coli gene (APC) mutations (these mutations being mutually exclusive). Read More

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http://dx.doi.org/10.1097/PAS.0000000000001517DOI Listing

KIF18B promotes tumor progression in osteosarcoma by activating β-catenin.

Cancer Biol Med 2020 May;17(2):371-386

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Bone and Soft Tissue Tumor, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Osteosarcoma is a common primary highly malignant bone tumor. Kinesin family member 18B () has been identified as a potential oncogene involved in the development and metastasis of several cancer types. While KIF18B overexpression in osteosarcoma tissue is clearly detected, its specific function in the disease process remains to be established. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309474PMC

Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.

Cell Commun Signal 2020 Jun 25;18(1):102. Epub 2020 Jun 25.

German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC). Characterization of Wnt effector pathways is key for our understanding of these processes and for developing therapeutic strategies that aim to preserve tissue homeostasis. O-glycosylated cell surface proteins, such as α-dystroglycan (α-DG), mediate cellular adhesion to extracellular matrix components. Read More

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http://dx.doi.org/10.1186/s12964-020-00561-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315491PMC

Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway.

Mol Med Rep 2020 Jun 24. Epub 2020 Jun 24.

Institute of Eyes, Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China.

Although the cardiovascular pharmacological actions of Tanshinone IIA (TanIIA) have been extensively studied, research on its roles in cardiac regeneration is still insufficient. The present study employed the cardiac myoblast cell line H9c2 to evaluate the possible roles of TanIIA in cardiac regeneration. It was found that certain concentration of TanIIA inhibited cell proliferation by suppressing the expression of proteins related to the cell cycle [cyclin dependent kinase (CDK)4, CDK6 and cyclin D1] and proliferation [c‑Myc, octamer‑binding transcription factor 4 (Oct4) and proliferating cell nuclear antigen (PCNA)] without inducing apoptosis. Read More

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http://dx.doi.org/10.3892/mmr.2020.11272DOI Listing

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.

Immunohorizons 2020 Jun 24;4(6):363-381. Epub 2020 Jun 24.

Unité Biologie Cellulaire des Lymphocytes, Département d'Immunologie, Institut Pasteur, INSERM-U1221, Ligue Nationale contre le Cancer-Equipe Labellisée Ligue 2018, F-75015 Paris, France;

Adenomatous polyposis coli (Apc) is a cell polarity regulator and a tumor suppressor associated with familial adenomatous polyposis and colorectal cancer. Apc involvement in T lymphocyte functions and antitumor immunity remains poorly understood. Investigating Apc-depleted human CD8 T cells and CD8 T cells from mutant mice, we found that Apc regulates actin and microtubule cytoskeleton remodeling at the immunological synapse, controlling synapse morphology and stability and lytic granule dynamics, including targeting and fusion at the synapse. Read More

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http://dx.doi.org/10.4049/immunohorizons.2000044DOI Listing

Liver metastasectomy-cytoreductive surgery- hyperthermic intraperitoneal chemotherapy and ileal pouch-anal anastomosis: A case report.

Int J Surg Case Rep 2020 Jun 13;72:397-401. Epub 2020 Jun 13.

2nd Department of Surgery, University Hospital Aretaieion, Athens, Greece.

Introduction: Cytoreductive surgery (CRS) with hyperthermal intraperitoneal chemotherapy (HIPEC) are established treatments for peritoneal carcinomatosis that prolong survival in carefully selected patients. At the time of diagnosis, 4-7% of patients with colorectal cancer (CRC) have metastasis to the peritoneum. There is a lack of evidence in the literature if J-pouch can be applied simultaneously with HIPEC to improve quality of life in patients with familial adenomatous polyposis syndrome (FAP) and peritoneal carcinomatosis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306530PMC

Juvenile Nasopharyngeal Angiofibroma and Familial Adenomatous Polyposis.

Ear Nose Throat J 2020 Jun 16:145561320934602. Epub 2020 Jun 16.

Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1177/0145561320934602DOI Listing

Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis.

Mol Genet Genomic Med 2020 Jun 16:e1348. Epub 2020 Jun 16.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

Background: Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and adenocarcinoma that is frequently accompanied by extracolonic neoplasm. The risk of gastric carcinoma is increasing in Western FAP patients as well as Asian patients.

Methods: We report the case of an FAP patient with fundic gland polyposis who developed gastric adenocarcinoma and metachronous pyloric gland adenomas. Read More

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http://dx.doi.org/10.1002/mgg3.1348DOI Listing

Endoscopic management of duodenal adenomas in patients with familial adenomatous polyposis.

Gastrointest Endosc 2020 Jun 11. Epub 2020 Jun 11.

Amsterdam UMC, University of Amsterdam, Department of Gastroenterology and Hepatology, Cancer Center Amsterdam, Amsterdam Gastroenterology & Metabolism, Meibergdreef 9, Amsterdam, Netherlands. Electronic address:

Background And Aims: Almost all patients with familial adenomatous polyposis (FAP) develop duodenal adenomas, with a 4% to 18% risk of progression into duodenal cancer. Prophylactic endoscopic resection of duodenal adenomas may prevent cancer and is considered safer than surgical alternatives; however, data are limited. Therefore, the aim of this study was to assess safety and effectiveness of endoscopic duodenal interventions in patients with FAP. Read More

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http://dx.doi.org/10.1016/j.gie.2020.05.065DOI Listing

EBV-miR-BART10-3p and EBV-miR-BART22 promote metastasis of EBV-associated gastric carcinoma by activating the canonical Wnt signaling pathway.

Cell Oncol (Dordr) 2020 Jun 12. Epub 2020 Jun 12.

Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Rd, Guangzhou, 510630, China.

Purpose: Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) constitutes the largest subpopulation in EBV-associated tumors worldwide. To date, 44 mature EBV-encoded microRNAs (EBV miRNAs) have been identified, but their roles in EBVaGC development are still poorly understood. In this study, we aimed to investigate the roles and targets of ebv-miR-BART10-3p (BART10-3p) and ebv-miR-BART22 (BART22) in EBVaGC. Read More

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http://dx.doi.org/10.1007/s13402-020-00538-0DOI Listing

Molecular mechanism of aquapontin (AQP3) in regulating differentiation and apoptosis of lung cancer stem cells through Wnt/GSK-3β/β-Catenin pathway.

J BUON 2020 Mar-Apr;25(2):828-834

Department of Hematology, the first Hospital of Jilin University, Changchun, China.

Purpose: To explore the effect of aquaporin-3 (AQP3) on the functions of lung cancer stem cells (LCSCs), and its molecular mechanism in regulating the differentiation and apoptosis of LCSCs through the Wnt/glycogen synthase kinase-3β (GSK-3β)/β-catenin pathway.

Methods: The stem cells were selected and the cell lines with low expression of AQP3 were constructed, followed by transcriptome sequencing. LCSCs were transfected with empty lentivirus in control group and transfected with AQP3 shRNA in interference group, and the low expression of AQP3 was inhibited using the Wnt pathway inhibitor XAV939 in interference + inhibitor group. Read More

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Pancreas- and Pylorus-Preserving Duodenectomy for Advanced Familial Duodenal Polyposis.

GE Port J Gastroenterol 2020 Apr 16;27(3):185-191. Epub 2019 Oct 16.

Serviço de Gastrenterologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Most patients with familial adenomatous polyposis (FAP) will develop duodenal polyps and 5% progress to cancer. Those with Spigelman stage IV have a 36% risk of cancer at 10 years. Endoscopic surveillance is necessary with local ablation for early disease. Read More

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http://dx.doi.org/10.1159/000503010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250337PMC

Chemoprevention in familial adenomatous polyposis: past, present and future.

Fam Cancer 2020 Jun 8. Epub 2020 Jun 8.

Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer syndrome characterized by colorectal adenomas and a near 100% lifetime risk of colorectal cancer (CRC). Prophylactic colectomy, usually by age 40, is the gold-standard therapy to mitigate this risk. However, colectomy is associated with morbidity and fails to prevent extra-colonic disease manifestations, including gastric polyposis, duodenal polyposis and cancer, thyroid cancer, and desmoid disease. Read More

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http://dx.doi.org/10.1007/s10689-020-00189-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276278PMC

Presentation and Follow-up of Familial Adenomatous Polyposis: Differences Between APC and MUTYH Mutations.

Cir Esp 2020 Jun 3. Epub 2020 Jun 3.

División de Cirugía Colorrectal, Departamento de Cirugía General, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.

Background: Familial adenomatous polyposis is described as one of the common two types of genetic disorders: APC and MUTYH gene associated polyposis syndrome and the clinical differences between the two can sometimes be unclear.

Materials And Methods: A retrospective analysis and comparison was made of clinical, surgical, and histological criteria, mutation types and the long-term results of patients who underwent genetic analysis which resulted in the diagnosis of Familial Adenomatous Polyposis between 1984 and 2018.

Results: Of the total 71 patients included in the study, 14 were identified with the MUTYH gene, and 57 with the APC mutation. Read More

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http://dx.doi.org/10.1016/j.ciresp.2020.04.033DOI Listing

Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.

Int J Colorectal Dis 2020 Jun 5. Epub 2020 Jun 5.

Division of Gastroenterology and Hematology/Oncology Department of Medicine, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.

Introduction: Familial adenomatous polyposis (FAP) is typically characterized by more than hundred adenomatous polyps in the colorectum, caused by germline APC mutation. A small proportion of the polyps progress to colorectal adenocarcinoma via adenoma-carcinoma sequence. Serrated lesions and polyps, characterized by a serrated architecture of the epithelium, are noted for two types of genetic pathways in colorectal carcinogenesis. Read More

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http://dx.doi.org/10.1007/s00384-020-03657-0DOI Listing

Radiotherapy in the treatment of aggressive fibromatosis: experience from a single institution.

Radiat Oncol 2020 Jun 5;15(1):143. Epub 2020 Jun 5.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Desmoid-type fibromatosis is a rare, potentially locally aggressive disease. Herein we present our experience in the treatment with radiotherapy.

Methods And Materials: In total 40 patients who received 44 treatments from 2009 to 2018 at the Heidelberg University Hospital with photons (N = 28) as well as protons (N = 15) and carbon ions (N = 1) were investigated. Read More

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http://dx.doi.org/10.1186/s13014-020-01565-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275436PMC

Risks, Benefits, and Effects on Management for Biopsy of the Papilla in Patients with Familial Adenomatous Polyposis.

Clin Gastroenterol Hepatol 2020 May 31. Epub 2020 May 31.

Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States. Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States.

Background & Aims: Ampullary and duodenal cancer are the leading causes of death in patients with familial adenomatous polyposis (FAP) after colectomy has been performed. Risk of duodenal cancer is determined based on Spigelman stage (SS) of duodenal polyposis. Guidelines recommend endoscopic surveillance of the duodenum and visualization of the papilla to stage duodenal polyposis. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.05.054DOI Listing
May 2020
7.896 Impact Factor

Characteristics of early-onset pancreatic cancer and its association with familial pancreatic cancer and hereditary pancreatic cancer syndromes.

Ann Gastroenterol Surg 2020 May 27;4(3):229-233. Epub 2020 Mar 27.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

The incidence of pancreatic cancer is high among those in their sixties to seventies but low in those in their fifties or younger. Although there is no unified definition regarding the age of early-onset pancreatic cancer, previously published reports suggest that, compared to later-onset pancreatic cancer patients, early-onset pancreatic cancer patients tend to be detected at advanced stages and thus have poor prognoses, but they do not show significantly higher rates of patients with genetic factors. On the other hand, it has been reported that patients with familial pancreatic cancer and hereditary pancreatic cancer syndromes often develop pancreatic cancer at a young age. Read More

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http://dx.doi.org/10.1002/ags3.12326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240141PMC

Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review.

BMC Gastroenterol 2020 Jun 1;20(1):167. Epub 2020 Jun 1.

Department of Colorectal Surgery, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China.

Background: Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A. Due to its rarity and complex clinical manifestation, misdiagnosis often occurs in clinical practice.

Case Presentation: A 42-year-old man with multiple pedunculated colorectal polyps and concomitant rectal adenocarcinoma was admitted to our hospital. Read More

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http://dx.doi.org/10.1186/s12876-020-01238-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268223PMC
June 2020
2.365 Impact Factor

Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF-1α/VEGF pathway in traumatic brain injury.

Brain Behav 2020 May 30:e01675. Epub 2020 May 30.

Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.

Objective: Traumatic brain injury (TBI) results not only in gray matter damage, but also in severe white matter injury (WMI). Previous findings support hypoxic preconditioning (HP) could augment the efficacy of bone marrow stromal cell (BMSC) transplantation in a TBI mouse model. However, whether HP-treated BMSCs (H-BMSCs) could overcome remyelination failure after WMI is unclear, and the molecular mechanisms remain to be explored. Read More

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http://dx.doi.org/10.1002/brb3.1675DOI Listing

Double-balloon endoscopy facilitates efficient endoscopic resection of duodenal and jejunal polyps in patients with familial adenomatous polyposis.

Endoscopy 2020 May 28. Epub 2020 May 28.

Jichi medical University, Department of medicine, Division of gastroenterology, Shimotsuke, Japan.

Background Many patients with familial adenomatous polyposis (FAP) have adenomatous polyps of the duodenum and the jejunum. We aimed to elucidate the long-term outcomes after double-balloon endoscopy (DBE)-assisted endoscopic resection of duodenal and jejunal polyps in patients with FAP. Methods We retrospectively reviewed patients who underwent more than two sessions of endoscopic resection using DBE from August 2004 to July 2018. Read More

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http://dx.doi.org/10.1055/a-1189-9550DOI Listing

Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats.

Asian Pac J Cancer Prev 2020 May 1;21(5):1369-1389. Epub 2020 May 1.

Animal Reproduction and Artificial Insemination Department, Veterinary Division, National Research Centre, Dokki, Giza, Egypt .

Background: Colorectal cancer (CRC) is considered as the most common type of gastrointestinal cancers. Chemotherapy became limited due to the adverse side effects. Therefore, the most effective Croton tiglium extract was selected to be incorporated by silver nanoparticles (Ag-NPs) then evaluated against colon cancer induced by azoxymethane (AOM) in rats. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1369DOI Listing
May 2020
1.500 Impact Factor

Familial Adenomatous Polyposis in Dogs: Hereditary Gastrointestinal Polyposis in Jack Russell Terriers with Germline APC Mutations.

Carcinogenesis 2020 May 23. Epub 2020 May 23.

Laboratory of Veterinary Pathology, Gifu University, Yanagido, Gifu, Japan.

Many hereditary disorders in dogs have equivalents in humans and thus attract attention as natural animal models. Breed predisposition to certain diseases often provides promising clues to explore novel hereditary disorders in dogs. Recently, cases of gastrointestinal (GI) polyps in Jack Russell Terriers (JRTs) have increased in Japan. Read More

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http://dx.doi.org/10.1093/carcin/bgaa045DOI Listing

Timing of prophylactic colectomy in familial adenomatous polyposis.

Colorectal Dis 2020 May 22. Epub 2020 May 22.

Department of Gastroenterological Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Aim: The aim was to evaluate the timing of prophylactic colectomy in patients with familial adenomatous polyposis (FAP) in Finland.

Method: All Finnish FAP patients were included from the years 1963-2018. Among the 452 FAP patients studied, 252 were called up as relatives of the proband. Read More

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http://dx.doi.org/10.1111/codi.15151DOI Listing

Does ileoanal pouch surgery increase the risk of desmoid in patients with familial adenomatous polyposis?

Int J Colorectal Dis 2020 Aug 20;35(8):1599-1605. Epub 2020 May 20.

Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancun Er Heng Rd., Guangzhou, 510655, Guangdong, China.

Purpose: Patients with familial adenomatous polyposis (FAP) may undergo either ileorectal anastomosis (IRA) or ileal pouch anal anastomosis (IPAA) depending on the degree of rectal involvement. Desmoid tumors (DTs) may arise postoperatively. Whether IPAA is associated with a higher risk of DTs as compared with IRA remains controversial. Read More

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http://dx.doi.org/10.1007/s00384-020-03578-yDOI Listing

Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis.

Aging (Albany NY) 2020 May 20;12(11):10527-10543. Epub 2020 May 20.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived mesenchymal stem cells (HAMSCs)-droved osteogenesis in HBMSCs. Read More

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http://dx.doi.org/10.18632/aging.103277DOI Listing

Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction.

Genet Med 2020 May 19. Epub 2020 May 19.

Service de Génétique et Biologie Moléculaires, Hôpital Cochin, APHP Centre Université de Paris and Inserm UMR_S1016, Institut Cochin, Université de Paris, Paris, France.

Purpose: Polymerase proofreading-associated polyposis is a dominantly inherited colorectal cancer syndrome caused by exonuclease domain missense variants in the DNA polymerases POLE and POLD1. Manifestations may also include malignancies at extracolonic sites. Cancer risks in this syndrome are not yet accurately quantified. Read More

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http://dx.doi.org/10.1038/s41436-020-0828-zDOI Listing

The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report.

Acta Med Port 2020 May 4;33(5):297-304. Epub 2020 May 4.

Medical Faculty. University of Porto. Porto. Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto. Institute of Molecular Pathology and Immunology. Universidade do Porto. Porto. Department of Pathology. Medical Faculty. University of Porto. Porto. Portugal.

Introduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor development, using sporadic and familial adenomatous polyposis related colorectal adenomas as a model. Read More

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http://dx.doi.org/10.20344/amp.12462DOI Listing

Long-Term Outcomes of Pancreas-Sparing Duodenectomy for Duodenal Polyposis in Familial Adenomatous Polyposis Syndrome.

J Gastrointest Surg 2020 May 14. Epub 2020 May 14.

Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, A100, Cleveland, OH, 44195, USA.

Background: Pancreas-sparing duodenectomy (PSD) offers definitive therapy for duodenal polyposis associated with familial adenomatous polyposis (FAP). We reviewed the long-term complications of PSD and evaluated the incidence of high-grade dysplasia (HGD) and cancer in the remaining upper gastrointestinal tract.

Methods: Forty-seven FAP patients with duodenal polyposis undergoing PSD from 1992 to 2019 were reviewed. Read More

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http://dx.doi.org/10.1007/s11605-020-04621-7DOI Listing

Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1.

Blood Adv 2020 May;4(10):2124-2134

Institute of Experimental Biomedicine, University Hospital, and.

Rearrangements of the microtubule (MT) and actin cytoskeleton are pivotal for platelet biogenesis. Hence, defects in actin- or MT-regulatory proteins are associated with platelet disorders in humans and mice. Previous studies in mice revealed that loss of the actin-depolymerizing factor homology (ADF-H) protein Cofilin1 (Cof1) in megakaryocytes (MKs) results in a moderate macrothrombocytopenia but normal MK numbers, whereas deficiency in another ADF-H protein, Twinfilin1 (Twf1), does not affect platelet production or function. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252539PMC

Cancer Genetics.

Surg Clin North Am 2020 Jun 16;100(3):483-498. Epub 2020 Apr 16.

Department of Surgery, St. Vincent's Medical Center, Bridgeport, CT, USA; Frank H. Netter MD School of Medicine, Quinnipiac University, North Haven, CT, USA. Electronic address:

For most individuals, cancer development is multifactorial; however, up to 10% of all cancers are related to an inherited genetic mutation. As health care shifts to having a greater emphasis on prevention, care providers, including general surgeons, will need to play a role in identifying patients at high risk for cancer development. Genetic testing provides a tool to determine those patients with a genetic mutation and to whom appropriate preventive care and treatment may be offered. Read More

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http://dx.doi.org/10.1016/j.suc.2020.02.012DOI Listing

Desmoid tumours: a perfect example for making progress in treatment management through international collaboration.

Authors:
B Kasper

ESMO Open 2019 11;4(6)

Sarcoma Unit, Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany

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http://dx.doi.org/10.1136/esmoopen-2019-000636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001096PMC
November 2019

Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes.

Cell Prolif 2020 Jun 11;53(6):e12825. Epub 2020 May 11.

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

Objectives: Little is known about the roles of integral membrane proteins beyond channels, carriers or receptors in meiotic oocytes. The transmembrane protein Fam70A was previously identified as a likely "female fertility factor" in Fox3a-knockout mouse ovaries where almost all follicles underwent synchronous activation and the mice became infertile very early. However, whether Fam70A functions in oocyte meiosis remains unknown. Read More

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http://dx.doi.org/10.1111/cpr.12825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309945PMC

Double mutation of APC and BRCA1 in an Italian family.

Cancer Genet 2020 Jun 28;244:32-35. Epub 2020 Apr 28.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 7, 80138 Naples, Italy; U.O.C. Clinical and Molecular Pathology, A.O.U. University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Familial adenomatous polyposis (FAP) is a rare genetic disorder caused mainly by monoallelic mutations of APC gene. The hereditary breast and ovarian cancer (HBOC) syndrome is an autosomal dominantly inherited disease, which mostly predisposes to breast and ovarian cancers as a result of germline mutations in BRCA1 or BRCA2 genes. In a family, mutations in two cancer susceptibility genes are extremely rare. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.04.074DOI Listing

Clinicopathologic and Molecular Characteristics of Familial Adenomatous Polyposis-associated Traditional Serrated Adenoma.

Am J Surg Pathol 2020 May 6. Epub 2020 May 6.

Division of Diagnostic Pathology.

Colorectal carcinogenesis in familial adenomatous polyposis (FAP) follows a conventional adenoma-carcinoma sequence. However, previous studies have also reported the occurrence of traditional serrated adenomas (TSAs) in patients with FAP. In the present study, we analyzed the clinicopathologic and molecular features of 37 TSAs from 21 FAP patients. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001502DOI Listing

MicroRNA-663b enhances migration and invasion by targeting adenomatous polyposis coli 2 in colorectal carcinoma cells.

Oncol Lett 2020 Jun 27;19(6):3701-3710. Epub 2020 Mar 27.

Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Colorectal carcinoma (CRC) is one of the leading causes of cancer-associated mortality worldwide. Dysregulation of microRNA (miR)-663b has been reported in a variety of diseases. However, the specific biological function of miR-663b in CRC requires further investigation. Read More

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http://dx.doi.org/10.3892/ol.2020.11482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202279PMC

[A Surgical Case of Desmoid Tumor in the Transverse Mesocolon with Pancreatic Invasion].

Gan To Kagaku Ryoho 2020 Jan;47(1):71-75

Dept. of Surgery, NTT Medical Center Tokyo.

A 40-year-old man with no previous history of abdominal surgery or noteworthy family history presented to our hospital because of a palpable abdominal mass. Abdominal CT revealed a 9 cm diameter mass in the mesocolon. The differential diagnosis included desmoid tumor, and right hemicolectomy with partial resection of the pancreas head and duodenum was performed. Read More

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January 2020

Insights and updates on endoscopic papillectomy.

Expert Rev Gastroenterol Hepatol 2020 May 22:1-10. Epub 2020 May 22.

Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

: Endoscopic papillectomy (EP) has been established as a useful endoscopic therapy by the efforts of many pancreatobiliary endoscopists and is presently accepted as a reliable alternative therapy to surgery in patients with ampullary adenoma. Moreover, there have been numerous advancements in EP techniques in recent years. Various approaches and attempts toward expanding the indications of endoscopic resection have been reported. Read More

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http://dx.doi.org/10.1080/17474124.2020.1766965DOI Listing

Surveillance for pathology associated with cancer on endoscopy (SPACE): criteria to identify high-risk gastric polyps in familial adenomatous polyposis.

Gastrointest Endosc 2020 May 4. Epub 2020 May 4.

Department of Gastroenterology, Hepatology and Nutrition,; Department of Colorectal Surgery,; Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic.

Background And Aims: Gastric cancer is an extracolonic manifestation of familial adenomatous polyposis (FAP) and associated with high-risk gastric polyps. There are no known endoscopic criteria to identify these high-risk polyps. Our aim was to develop endoscopic criteria to identify high-risk polyps on endoscopy in FAP. Read More

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http://dx.doi.org/10.1016/j.gie.2020.04.065DOI Listing