3,886 results match your criteria Fallopian Tube Disorders


[Endometriosis].

Ther Umsch 2020 ;77(2):57-61

Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich.

Endometriosis Endometriosis, which is the presence of functional endometrial tissue outside the endometrium, represents one of the most common gynecological diseases. Given the variability of the symptoms depending on the exact localization of the disease, it is not uncommon for a patient to be diagnosed only after approximately 10 years of suffering. Localizations of the disease can include the typical endometrioma of the ovaries and in particular the lesser pelvis (e. Read More

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http://dx.doi.org/10.1024/0040-5930/a001153DOI Listing
January 2020

Atezolizumab in combination with bevacizumab and chemotherapy versus bevacizumab and chemotherapy in recurrent ovarian cancer - a randomized phase III trial (AGO-OVAR 2.29/ENGOT-ov34).

Int J Gynecol Cancer 2020 Jun 30. Epub 2020 Jun 30.

AGO & University Mannheim, Mannheim, Germany.

Background: Improvement in clinical outcomes of patients with platinum-resistant disease is an unmet medical need and trials in this population are urgently needed. Checkpoint-inhibitors have already shown activity in multiple other tumor entities and ovarian cancer, especially in the combination with anti-angiogenic treatment.

Primary Objective: To test if the activity of non-platinum-based chemotherapy and bevacizumab could be improved by the addition of atezolizumab. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001572DOI Listing

Perineural spread of clear cell adenocarcinoma of müllerian origin resulting in neoplastic lumbosacral plexopathy.

World Neurosurg 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Adenocarcinomas of müllerian origin are malignancies derived from tissues of the proximal third of the vagina, cervix, uterus and fallopian tubes. These organs develop from the embryologic müllerian ducts. While reports of perineural spread of certain uterine and cervical carcinomas exist in the literature, to our knowledge, no reports of clear cell type müllerian adenocarcinoma presenting with neural invasion of the lumbosacral plexus exist in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.121DOI Listing

Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications.

J Clin Med 2020 Jun 18;9(6). Epub 2020 Jun 18.

Centre for Women's Health Research, Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.

Endometriosis is a common, oestrogen driven chronic condition, where endometrium-like epithelial and stromal cells exist in ectopic sites. At present, no curative treatments are available and the existing evidence for disease progression is conflicting. The pathogenesis is still unknown and evidently complex, as mechanisms of initiation may depend on the anatomical distribution of endometriotic lesions. Read More

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http://dx.doi.org/10.3390/jcm9061905DOI Listing

Post-operative pancreatic fistula following splenectomy with or without distal pancreatectomy at cytoreductive surgery in advanced ovarian cancer.

Int J Gynecol Cancer 2020 Jul 16;30(7):1043-1051. Epub 2020 Jun 16.

Northern Gynaecological Oncology Centre, Queen Elizabeth Hospital, Gateshead, United Kingdom.

Objective: Splenectomy with or without distal pancreatectomy may be necessary at time of cytoreductive surgery to achieve complete cytoreduction in advanced ovarian cancer. However, these procedures have been associated with peri-operative morbidity. The aims of this study were to determine the incidence of distal pancreatectomy among patients undergoing splenectomy during cytoreductive surgery for advanced ovarian cancer and to determine the incidence, management, treatment, and prognosis of patients with post-operative pancreatic fistula. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001312DOI Listing

[ENDOMETRIOSIS AND PREGNANCY (REVIEW)].

Georgian Med News 2020 Apr(301):63-68

I.M. Sechenov First Moscow State Medical University (Seche-nov University), Russia.

The purpose of this review was to systematize the data on the effect of endometriosis on the fertility index, the course of pregnancy, and the modern diagnosis of changes the endometriotic implants during pregnancy. There are many factors that can potentially affect fertility in patients with endometriosis: anatomical changes in the pelvic floor, impaired transport function of the fallopian tubes due to the formation of adhesions, impaired steroid and folliculogenesis, anovulation and peritoneal changes that contribute to the formation of a harmful prooxidant microenvironment, which can affect the quality and quantity of oocytes and cause a violation of the susceptibility of the endometrium. If the patient with endometriosis still managed to get pregnant, then the problem of maintaining this pregnancy arises even more. Read More

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Impact of PD-L1 and T-cell inflamed gene expression profile on survival in advanced ovarian cancer.

Int J Gynecol Cancer 2020 Jul 11;30(7):1034-1042. Epub 2020 Jun 11.

Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.

Objective: Programmed death ligand 1 (PD-L1) expression affects tumor evasion of immune surveillance. The prognostic value and relationship of PD-L1 expression to T-cell-inflamed immune signatures in ovarian cancer are unclear. The purpose of this study is to evaluate the impact of PD-L1 on overall survival and its correlation with an immune-mediated gene expression profile in patients with advanced ovarian cancer. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001109DOI Listing

Inhibiting ULK1 kinase decreases autophagy and cell viability in high-grade serous ovarian cancer spheroids.

Am J Cancer Res 2020 1;10(5):1384-1399. Epub 2020 May 1.

The Mary & John Knight Translational Ovarian Cancer Research Unit, London Regional Cancer Program London, Ontario, Canada.

Metastasis in high-grade serous ovarian cancer (HGSOC) occurs through an unconventional route that involves exfoliation of cancer cells from primary tumors and peritoneal dissemination via multicellular clusters or spheroids. Previously, we demonstrated autophagy induction in HGSOC spheroids grown and in spheroids collected from ovarian cancer patient ascites; thus, we speculate that autophagy may contribute to spheroid cell survival and overall disease progression. Hence, in this study we sought to evaluate whether ULK1 (unc-51-like kinase-1), a serine-threonine kinase critical for stress-induced autophagy, is important for autophagy regulation in HGSOC spheroids. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269771PMC

Risk-stratifying clinicopathologic criteria for ovarian preservation in premenopausal women with early stage low-risk endometrial cancer.

Int J Gynaecol Obstet 2020 Jun 7. Epub 2020 Jun 7.

Department of Obstetrics and Gynecology, Yale New Haven Health - Bridgeport Hospital, Bridgeport, CT, USA.

Objective: To establish the rate of occult ovarian micro-metastases in early stage disease and to provide an eligibility framework for providers to consider ovarian preservation in a patient population with presumed early stage disease.

Methods: A retrospective review from January 2005 to December 2010 identified women with presumed early stage endometrial cancer from a single institutional database. Inclusion criteria included: (1) FIGO grade 1 endometrioid endometrial cancer on endometrial biopsy; or (2) the same pathology as (1) on frozen section specimen with less than 50% myometrial biopsy; and (3) no evidence of metastatic disease on preoperative imaging or visible metastatic disease in the peritoneal cavity. Read More

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http://dx.doi.org/10.1002/ijgo.13254DOI Listing

Aggressive surgery for advanced ovarian cancer decreases the risk of intraperitoneal recurrence.

Int J Clin Oncol 2020 Jun 4. Epub 2020 Jun 4.

Department of Gynecology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan.

Background: This study investigated the pattern of first recurrence of advanced ovarian cancer before and after the introduction of aggressive surgery.

Methods: We investigated 291 patients with stage III/IV epithelial ovarian, fallopian tube, and peritoneal cancer. Aggressive surgery including gastrointestinal and upper abdominal surgeries was introduced for advanced ovarian cancer in 2008. Read More

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http://dx.doi.org/10.1007/s10147-020-01714-wDOI Listing

Enhancing a Successful Pregnancy and Delivery After ICSI in Advanced-Age Woman with Concurrent Disorders: A Case Report.

J Reprod Infertil 2020 Apr-Jun;21(2):146-150

Infertility Research and Treatment Center, Motazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The objective of this case presentation was describing a live birth in an advanced-age woman with an extremely enlarged uterus, an ovary with blocked fallopian tubes, hypothyroidism and generalized anxiety disorder caused by child-birth following intracytoplasmic sperm injection/embryo transfer (ICSI-ET) with autologous oocytes.

Case Presentation: A 47-year-old patient with an enlarged uterus due to recurrent multiple fibroids following myomectomy was referred to clinical laboratory with a high level of desire to follow the prescribed recommendations and approaches to retrieve her fertility. The patient underwent two cycles of oocyte retrieval and two rounds of frozen-thawed embryo transfer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253933PMC

Use of ablation and ultrasonic aspiration at primary debulking surgery in advanced stage ovarian, fallopian tube, and primary peritoneal cancer.

Int J Gynecol Cancer 2020 Jul 2;30(7):1052-1057. Epub 2020 Jun 2.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: Ovarian cancer patients with miliary disease have the lowest rates of complete surgical resection and poorest survival. Adjunct surgical techniques may potentially increase rates of complete surgical resection. No studies have evaluated the use of these techniques in primary debulking surgery for ovarian cancer patients with miliary disease. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001466DOI Listing

Differential blood count as triage tool in evaluation of pelvic masses.

Int J Gynecol Cancer 2020 Jun 2. Epub 2020 Jun 2.

Dana Farber Cancer Institute, Boston, Massachusetts, USA.

Objective: Triaging patients with presumptive ovarian cancer to the appropriate specialist may improve survival. Therefore, there is increasing interest in complementary diagnostic markers to the standard serum CA125. In patients with pelvic masses, we examined the ability of epidemiologic variables and preoperative differential blood counts to improve detection of ovarian cancer over CA125 alone. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001103DOI Listing

Niche role of MRI in the evaluation of female infertility.

Indian J Radiol Imaging 2020 Jan-Mar;30(1):32-45. Epub 2020 Mar 30.

Department of Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, India.

Infertility is a major social and clinical problem affecting 13-15% of couples worldwide. The pelvic causes of female infertility are categorized as ovarian disorders, tubal, peritubal disorders, and uterine disorders. Appropriate selection of an imaging modality is essential to accurately diagnose the aetiology of infertlity, since the imaging diagnosis directs the appropriate treatment to be instituted. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_377_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240899PMC

Primary hydatic cyst of the fallopian tube.

IDCases 2020 6;20:e00790. Epub 2020 May 6.

University of Tunis El Manar, Department of General Surgery, Trauma Center, Ben Arous, Tunisia.

Hydatid disease is endemic in Tunisia. The involvement of the female genital tract is uncommon, and the occurrence in the fallopian tube is exceptional. We present a case of a 42-year-old woman who had complained of a 4-month history of lower abdominal pain. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218290PMC

Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.

Mod Pathol 2020 May 15. Epub 2020 May 15.

International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN, USA.

Since the original description of pathogenic germline DICER1 variation underlying pleuropulmonary blastoma (PPB), the spectrum of extrapulmonary neoplasms known to be associated with DICER1 has continued to expand and now includes tumors of the ovary, thyroid, kidney, eye, and brain among other sites. This report documents our experience with another manifestation: a primitive sarcoma that resembles PPB and DICER1-associated sarcoma of the kidney. These tumors are distinguished by their unusual location in the peritoneal cavity, associated with visceral and/or parietal mesothelium. Read More

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http://dx.doi.org/10.1038/s41379-020-0558-4DOI Listing

Ectopic Pregnancy: Diagnosis and Management.

Am Fam Physician 2020 May;101(10):599-606

Mount Sinai School of Medicine, New York, NY, USA.

Ectopic pregnancy occurs when a fertilized ovum implants outside of the uterine cavity. In the United States, the estimated prevalence of ectopic pregnancy is 1% to 2%, and ruptured ectopic pregnancy accounts for 2.7% of pregnancy-related deaths. Read More

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Fallopian tube abnormalities in uterine serous carcinoma.

Gynecol Oncol 2020 May 11. Epub 2020 May 11.

Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.

Objective: Uterine serous carcinoma (USC) is presumed to arise from endometrial intra-epithelial carcinoma (EIC), whereas tubo-ovarian high-grade serous carcinomas have similar precursor lesions in the Fallopian tube, i.e. serous tubal intra-epithelial carcinoma (STIC). Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.707DOI Listing

Anterior mediastinal metastasis of primary fallopian tube adenocarcinoma: a case report.

J Cardiothorac Surg 2020 May 11;15(1):77. Epub 2020 May 11.

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Anshan Road No 154, Heping District, Tianjin, 300052, China.

Background: Primary fallopian tube carcinoma (PFTC) is a malignant tumor of the female genital tract that mostly presents intraperitoneal dissemination in clinical practice. The incidence of upper anterior mediastinal metastasis in PFTCs is extremely rare. We herein report a rare case of PFTC mediastinal metastasis after radical resection. Read More

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http://dx.doi.org/10.1186/s13019-020-01111-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216506PMC

Laparoscopic tuboplasty for mild distal tubal disease.

Fertil Steril 2020 Jun 5;113(6):1330-1332. Epub 2020 May 5.

Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To review tuboplasty techniques for alleviating fallopian tube blockage.

Design: A step-by-step explanation of the techniques that comprise tuboplasty-fimbrioplasty, salpingo-ovariolysis, and salpingostomy-with surgical video footage.

Setting: Academic medical center. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.02.106DOI Listing

The rapid adoption of opportunistic salpingectomy at the time of hysterectomy for benign gynecologic disease in the United States.

Am J Obstet Gynecol 2020 Apr 30. Epub 2020 Apr 30.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA. Electronic address:

Background: Mounting evidence for the role of distal fallopian tubes in the pathogenesis of epithelial ovarian cancer has led to opportunistic salpingectomy being increasingly performed at the time of benign gynecologic surgery. Opportunistic salpingectomy has now been recommended as best practice in the United States to reduce future risk of ovarian cancer even in low-risk women. Preliminary analyses have suggested that performance of opportunistic salpingectomy is increasing. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.04.028DOI Listing

Rucaparib for patients with platinum-sensitive, recurrent ovarian carcinoma (ARIEL3): post-progression outcomes and updated safety results from a randomised, placebo-controlled, phase 3 trial.

Lancet Oncol 2020 05;21(5):710-722

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: In ARIEL3, rucaparib maintenance treatment significantly improved progression-free survival versus placebo. Here, we report prespecified, investigator-assessed, exploratory post-progression endpoints and updated safety data.

Methods: In this ongoing (enrolment complete) randomised, placebo-controlled, phase 3 trial, patients aged 18 years or older who had platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal, or fallopian tube carcinoma and an Eastern Cooperative Oncology Group performance status of 0 or 1 who had received at least two previous platinum-based chemotherapy regimens and responded to their last platinum-based regimen were randomly assigned (2:1) to oral rucaparib (600 mg twice daily) or placebo in 28-day cycles using a computer-generated sequence (block size of six with stratification based on homologous recombination repair gene mutation status, progression-free interval following penultimate platinum-based regimen, and best response to most recent platinum-based regimen). Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30061-9DOI Listing
May 2020
24.690 Impact Factor

Long-term outcomes following a diagnosis of ovarian cancer at the time of preventive oophorectomy among and mutation carriers.

Int J Gynecol Cancer 2020 Jun 30;30(6):825-830. Epub 2020 Apr 30.

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada

Introduction: Preventive bilateral salpingo-oophorectomy is the most effective means of reducing the risk of ovarian cancer among women with an inherited or mutation. Some women are diagnosed with an invasive cancer (ovarian or fallopian tube) at the time of preventive surgery, referred to as an 'occult' cancer. The survival experience of these women is not known. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001141DOI Listing

Evaluation of surgical resection in advanced ovarian, fallopian tube, and primary peritoneal cancer: laparoscopic assessment. A European Network of Gynaecological Oncology Trial (ENGOT) group survey.

Int J Gynecol Cancer 2020 Jun 30;30(6):819-824. Epub 2020 Apr 30.

Grupo Español de Investigación en Cáncer de Ovario (GEICO) and Department of Medical Oncology, Clínica Universidad de Navarra, Madrid, Spain.

Objective: Laparoscopy is one of the diagnostic tools available for the complex clinical decision-making process in advanced ovarian, fallopian tube, and peritoneal carcinoma. This article presents the results of a survey conducted within the European Network of Gynaecological Oncology Trial (ENGOT) group aimed at reviewing the current patterns of practice at gynecologic oncology centers with regard to the evaluation of resection in advanced ovarian, fallopian tube, and peritoneal carcinoma.

Methods: A 24-item questionnaire was sent to the chair of the 20 cooperative groups that are currently part of the ENGOT group, and forwarded to the members within each group. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001172DOI Listing

The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders.

Hum Reprod Update 2020 Jun;26(4):586-602

UCIBIO, REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.

Background: The endocannabinoid system (ECS) consists of the cannabinoid receptors CB1 and CB2, the main endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and their metabolic enzymes N-acylphosphatidylethanolamine-specific phospholipase D, fatty acid amide hydrolase, diacylglycerol lipase and monoacylglycerol lipase. This system is involved in the modulation of essential physiological processes. Its role in the reproductive system has become significantly important in recent years, given its major role in events such as gametogenesis, decidualisation, implantation and placentation. Read More

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http://dx.doi.org/10.1093/humupd/dmaa005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317288PMC

Primary fallopian tube carcinoma (PFTC) in a BRIP-1 mutation carrier: the first case report.

Fam Cancer 2020 Apr 24. Epub 2020 Apr 24.

Department of Medical and Surgical Sciences for Mother, Child and Adult, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy.

Some hereditary ovarian cancer cases can be associated with a mutation of a gene involved in the DNA double-strand break repair system other than BRCA, such as BRIP1. This mutation is an emerging indication for prophylactic risk-reducing salpingo-oophorectomy (RRSO): however, anomalous tubal pathologic lesions have not yet been reported during RRSO performed for this specific indication (BRIP1), as largely reported for BRCA mutation carriers. An asymptomatic 64-year-old woman with a family history of ovarian and breast cancer agreed to undergo RRSO for a pathogenic variant of the BRIP1 gene (heterozygous NM_032043. Read More

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http://dx.doi.org/10.1007/s10689-020-00179-0DOI Listing

Management of a Case of Peritonitis Due to Infection Following Pelvic Inflammatory Disease (PID).

Antibiotics (Basel) 2020 04 18;9(4). Epub 2020 Apr 18.

Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-Spedali Civili, 25123 Brescia, Italy.

Pelvic inflammatory disease (PID), a serious infection in sexually active women, is one of the reasons for which females seek care in emergency departments and therefore represents an important public health problem. PID is the result of an endocervical infection with different microorganisms, which then ascend to the endometrium and fallopian tubes. Symptoms of PID may be mild and aspecific, making its diagnosis difficult. Read More

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http://dx.doi.org/10.3390/antibiotics9040193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235818PMC

Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial.

Lancet Oncol 2020 05 16;21(5):699-709. Epub 2020 Apr 16.

Haematology-Oncology Department, Centre Hospitalier Régional et Universitaire de Strasbourg Hôpital Civil, Strasbourg, France.

Background: State-of-the art therapy for recurrent ovarian cancer suitable for platinum-based re-treatment includes bevacizumab-containing combinations (eg, bevacizumab combined with carboplatin-paclitaxel or carboplatin-gemcitabine) or the most active non-bevacizumab regimen: carboplatin-pegylated liposomal doxorubicin. The aim of this head-to-head trial was to compare a standard bevacizumab-containing regimen versus carboplatin-pegylated liposomal doxorubicin combined with bevacizumab.

Methods: This multicentre, open-label, randomised, phase 3 trial, was done in 159 academic centres in Germany, France, Australia, Austria, and the UK. Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30142-XDOI Listing

Incidence trends for epithelial peritoneal, ovarian, and fallopian tube cancer during 1999-2016: a retrospective study based on the Korean National Cancer Incidence Database.

J Gynecol Oncol 2020 Jul 26;31(4):e56. Epub 2020 Feb 26.

Center for Gynecologic Cancer, National Cancer Center, Goyang, Korea.

Objective: Primary peritoneal cancer (PPC), ovarian cancer (OC), and fallopian tube cancer (FTC) are considered as a single disease group. As knowledge of the pathogenesis and clinical presentation of peritoneal, ovarian, and fallopian tube (POFT) cancer grows, the tendencies in OC diagnosis are changing. We investigate the incidence and clinical characteristics of epithelial POFT based on cancer site and histologic type. Read More

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http://dx.doi.org/10.3802/jgo.2020.31.e56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286760PMC

A randomized phase II evaluation of weekly gemcitabine plus pazopanib versus weekly gemcitabine alone in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma.

Gynecol Oncol 2020 Jun 1;157(3):585-592. Epub 2020 Apr 1.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology. Duke Unviersity Medical Center, Durham, NC, USA.

Objective: Angiogenesis inhibition is a valuable strategy for ovarian cancer (EOC). Pazopanib (paz) is a potent small molecular inhibitor of VEGF-1, -2, -3, PDGFR, c-kit, and has activity as a single agent in ovarian cancer. We designed a trial to assess the benefit of adding paz to gemcitabine (gem) in patients with recurrent EOC. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.10.014DOI Listing

Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.

Int J Cancer 2020 Apr 3. Epub 2020 Apr 3.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. Read More

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http://dx.doi.org/10.1002/ijc.32999DOI Listing

Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer.

World J Surg Oncol 2020 Apr 1;18(1):64. Epub 2020 Apr 1.

Department of Obstetrics and Gynecology, Toho University Faculty of Medicine, 6-11-1, Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.

Background: In patients with epithelial ovarian cancer, whether metastasis to para-aortic lymph nodes located cephalad to the renal veins (supra-renal PAN) should be classified as regional lymph node metastasis or distant metastasis remains controversial. This study was a preliminary retrospective evaluation of the pattern of supra-renal PAN metastasis in patients with epithelial ovarian cancer.

Methods: The subjects were 25 patients with epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer who underwent systematic dissection of the para-aortic nodes, including the supra-renal PAN, and pelvic lymph nodes (PLN). Read More

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http://dx.doi.org/10.1186/s12957-020-01841-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114794PMC

Expression of cancer stem cell markers CD24, EPHA1 and CD9 and their correlation with clinical outcome in epithelial ovarian tumours.

Cancer Biomark 2020 ;28(3):397-408

Laboratory for Cancer Biology, Department of Medical Oncology and Clinical research, Cancer Institute (WIA), Chennai, Tamilnadu, India.

Background: There has been variability between laboratories in the identification of cancer stem cells (CSCs) markers for epithelial ovarian cancer (EOC). We have evaluated three new surface markers for EOC to identify CSCs precisely.

Methods: Three new putative CSCs specific surface markers CD9, CD24 and EPHA1 identified by a bioinformatics approach were evaluated in normal ovary, fallopian tube and ovarian tumours. Read More

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http://dx.doi.org/10.3233/CBM-201463DOI Listing
January 2020
1.186 Impact Factor

An interesting case of likely related bilateral breast cancer with metastasis in the fimbrial part of fallopian tube.

Hered Cancer Clin Pract 2020 19;18. Epub 2020 Mar 19.

1Division of Medical Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, 1000 Ljubljana, Slovenia.

Background: In a patient with a germline pathogenic variant with breast cancer, an adnexal mass can represent either a metachronous primary tumor or a metastasis of the breast cancer. A clear distinction between those two possibilities is crucial since treatments differ substantially and so does survival of the patient.

Case Presentation: We present a case of a 47-year-old patient with bilateral breast carcinoma with a germline pathogenic variant. Read More

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http://dx.doi.org/10.1186/s13053-020-00139-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081695PMC

Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.

Int J Gynecol Cancer 2020 Jun 23;30(6):888-892. Epub 2020 Mar 23.

Department of Gynaecology, Netherlands Cancer Institute, Amsterdam, The Netherlands

Background: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery improves recurrence-free and overall survival in patients with FIGO stage III ovarian cancer who are ineligible for primary cytoreductive surgery. The effect of HIPEC remains undetermined in patients who are candidates for primary cytoreductive surgery.

Primary Objective: The primary objective is to evaluate the effect of HIPEC on overall survival in patients with FIGO stage III epithelial ovarian cancer who are treated with primary cytoreductive surgery resulting in no residual disease, or residual disease up to 2. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001231DOI Listing

Disorders of Sex Development Are an Emerging Problem in French Bulldogs: A Description of Six New Cases and a Review of the Literature.

Sex Dev 2019 24;13(4):205-211. Epub 2020 Mar 24.

Disorders of sex development (DSD) are a well-known cause of sterility and reduced fertility in dogs. Here, we report on 6 new cases of DSD in French bulldogs diagnosed by us within the last year. The animals were phenotypical females who underwent detailed diagnosis due to the presence of an enlarged clitoris or a penis-like structure with atypically located urethral orifice (hypospadias). Read More

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http://dx.doi.org/10.1159/000506582DOI Listing

The tubal epigenome - An emerging target for ovarian cancer.

Pharmacol Ther 2020 Jun 18;210:107524. Epub 2020 Mar 18.

Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Graduate Program in Cell and Molecular Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address:

Ovarian cancer is the most lethal gynecologic malignancy in the United States. The mortality of this disease is primarily attributed to challenges in early detection and therapeutic resistance. Recent studies indicate that the majority of high-grade serous ovarian carcinomas (HGSCs) originate from aberrant fallopian tube epithelial (FTE) cells. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237289PMC
June 2020
9.723 Impact Factor

Systematic review of acceptability, cardiovascular, neurological, bone health and HRT outcomes following risk reducing surgery in BRCA carriers.

Best Pract Res Clin Obstet Gynaecol 2020 May 4;65:46-65. Epub 2020 Feb 4.

Wolfson Institute of Preventive Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK; Department of Gynaecological Oncology, St Bartholomew's Hospital, London, EC1A 7BE, UK; MRC Clinical Trials Unit, University College London, 90 High Holborn, London, WC1V 6LJ, UK. Electronic address:

Primary surgical prevention in the form of risk-reducing salpingo-oophorectomy (RRSO) is the most effective option and the gold standard for ovarian cancer (OC) risk-reduction, particularly given the absence of an effective national OC screening programme. However, premenopausal RRSO leads to premature surgical menopause with detrimental long-term health sequelae particularly in women who do not/are unable to take hormone replacement therapy (HRT). HRT uptake in women undergoing pre-menopausal oophorectomy appears low and is dependent on informed counselling, the safety of HRT and efficacy in mitigating the health sequelae of premature menopause. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2020.01.006DOI Listing

Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.

Ann Pharmacother 2020 Mar 16:1060028020912749. Epub 2020 Mar 16.

MCPHS University Worcester/Manchester, Worcester, MA, USA.

To review the efficacy and safety of niraparib for the treatment of recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer (OC, FTC, and PPC). A literature search via MEDLINE through PubMed from August 2013 to January 2020 was performed using the key terms , and . Completed and ongoing trials were identified through a review of the website trial registry https://www. Read More

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http://dx.doi.org/10.1177/1060028020912749DOI Listing

Unusual presentation of bilateral pyosalpinx mimicking an ovarian torsion: A case report.

Ann Med Surg (Lond) 2020 Apr 26;52:16-18. Epub 2020 Feb 26.

HealthPlus Fertility and Women's Health Center, Jeddah, Saudi Arabia.

Introduction: A pyosalpinx is the acute inflammation of the Fallopian tube fills up and swells with pus, which commonly results from inadequate or delayed treatment of pelvic inflammatory disease. Herein we report a case of bilateral pyosalpinx mimicking an ovarian torsion.

Presentation Of Case: We reported the case of a 27-year-old female patient, who presented to the emergency department with complaints of constant, worsening lower abdominal pain for 2-3 days. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052398PMC

Clinical relevance of circulating tumor cells in ovarian, fallopian tube and peritoneal cancer.

Arch Gynecol Obstet 2020 04 6;301(4):1027-1035. Epub 2020 Mar 6.

Department of Gynecology and Obstetrics, Asklepios Klinik Barmbek, Rübenkamp 220, 22307, Hamburg, Germany.

Purpose: Presence of circulating tumor cells (CTCs) is associated with impaired clinical outcome in several solid cancers. Limited data are available on the significance of CTCs in gynaecological malignancies. The aims of the present study were to evaluate the dynamics of CTCs in patients with ovarian, fallopian tube and peritoneal cancer during chemotherapy and to assess their clinical relevance. Read More

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http://dx.doi.org/10.1007/s00404-020-05477-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103005PMC

Integrated analysis of mRNA and protein expression profiling in tubal endometriosis.

Reproduction 2020 05;159(5):601-614

Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Tubal endometriosis (tubal EM) is a subtype of endometriosis (EM) associated with fallopian tube impairments and infertility. Since the molecular mechanism underlying tubal EM is not clear, we assume that an aberrant transcriptome of fallopian tube epithelium and microenvironment changes caused by cytokines in tubal fluid are possible causes. The aim of this study was to identify potential hub mRNAs/proteins of tubal EM through integrated transcriptomic and proteomic analyses and to elucidate significant pathways, cellular functions, and interaction networks during the initiation and progression of tubal EM. Read More

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http://dx.doi.org/10.1530/REP-19-0587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159149PMC
May 2020
3.174 Impact Factor

Is tubal endometriosis an asymmetric disease? A 17-year retrospective study.

Arch Gynecol Obstet 2020 03 29;301(3):721-727. Epub 2020 Feb 29.

Center of Reproductive Medicine, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910 Hengshan Road, Shanghai, 200030, China.

Purpose: To investigate whether there are left-right asymmetries in tubal endometriosis and the factors affecting this predisposition.

Methods: Women who underwent salpingectomy for gynecological diseases and were diagnosed with tubal endometriosis between January 2002 and July 2019 were included in the study. The frequencies of left and right tubal endometriosis were compared with the expected 50% using a binominal test. Read More

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http://dx.doi.org/10.1007/s00404-020-05465-xDOI Listing

The infected hematometra in a rudimentary noncommunicating horn misdiagnosed as pelvic mass: A case report.

Int J Surg Case Rep 2020 11;68:4-7. Epub 2020 Feb 11.

Department of Obstetrics and Gynecology, Sisters of Charity Hospital, University at Buffalo, Buffalo, New York, 14214, USA. Electronic address:

Introduction: The rudimentary noncommunicating horn with a functional endometrial cavity is rare and often challenging to diagnose because of the variety in clinical features. We present a case of a patient for whom the diagnosis of a uterine horn was missed during the prior cesarean section, which later successfully treated with robotic-assisted laparoscopic removal of a rudimentary noncommunicating horn of uterus and ipsilateral tube.

Presentation Of Case: A 20-year old woman, gravida 3 para 2, presented with a complaint of acute and severe pelvic pain with fever. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.01.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044467PMC
February 2020

Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035).

Gynecol Oncol Rep 2020 May 3;32:100546. Epub 2020 Feb 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.

Platinum-resistant, recurrent, high grade epithelial ovarian carcinoma remains challenging to treat. Chemotherapy produces limited responses with modest survival benefits in the treatment of recurrent disease. In this context, targeted therapies may improve upon conventional therapies. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021536PMC

Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications.

Cancer Lett 2020 Apr 15;476:152-160. Epub 2020 Feb 15.

Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address:

Ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause of cancer-related death in women. Although outcomes have improved in recent years, there remains an unmet clinical need to understand the early pathogenesis of ovarian cancer in order to identify new diagnostic approaches and agents of chemoprevention and chemotherapy. While high grade serous ovarian cancer (HGSOC), the most abundant histotype, was initially thought to arise from the ovarian surface epithelium, there is an increasing body of evidence suggesting that HGSOC originates in the fallopian tube. Read More

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http://dx.doi.org/10.1016/j.canlet.2020.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069002PMC

Examining indicators of early menopause following opportunistic salpingectomy: a cohort study from British Columbia, Canada.

Am J Obstet Gynecol 2020 Feb 15. Epub 2020 Feb 15.

Department of Gynaecology and Obstetrics, Division of Gynaecologic Oncology, University of British Columbia, Vancouver BC, Canada.

Background: The fallopian tube may often be the site of origin for the most common and lethal form of ovarian cancer, high-grade serous ovarian cancer. As a result, many colleges of obstetrics and gynecology, which include the American College of Obstetricians and Gynecologists, are recommending surgical removal of the fallopian tube (bilateral salpingectomy) at the time of other gynecologic surgeries (particularly hysterectomy and tubal sterilization) in women at general population risk for ovarian cancer, collectively referred to as opportunistic salpingectomy. Previous research has illustrated no increased risk of complications after opportunistic salpingectomy. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.02.005DOI Listing
February 2020

The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer.

Clin Cancer Res 2020 Jul 14;26(13):3397-3407. Epub 2020 Feb 14.

Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, Minnesota.

Purpose: Clear cell ovarian carcinoma (CCOC) is an aggressive disease that often demonstrates resistance to standard chemotherapies. Approximately 25% of patients with CCOC show a strong APOBEC mutation signature. Here, we determine which APOBEC3 enzymes are expressed in CCOC, establish clinical correlates, and identify a new biomarker for detection and intervention. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-2786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334080PMC