3,636 results match your criteria Fallopian Tube Disorders


Prophylactic salpingo-oophorectomy & surgical menopause for inherited risks of cancer: the need to identify biomarkers to assess the theoretical risk of premature coronary artery disease.

Womens Midlife Health 2018 27;4. Epub 2018 Apr 27.

1Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Health Research Innovation Centre, GB42, 3280 Hospital Dr NW, Calgary, AB T2N 4Z6 Canada.

Background: Some women with genetic risk of breast and/or ovarian cancer (e.g., BRCA1/2) opt to undergo prophylactic salpingo-oophorectomy (PSO, or surgical removal of the ovaries & fallopian tubes) in order to reduce their risk of cancer. Read More

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http://dx.doi.org/10.1186/s40695-018-0037-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297996PMC

The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release.

Front Microbiol 2019 31;10:73. Epub 2019 Jan 31.

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.

and release peptidoglycan (PG) fragments from the cell as the bacteria grow. For these PG fragments are known to cause damage to human Fallopian tube tissue in organ culture that mimics the damage seen in patients with pelvic inflammatory disease. also releases pro-inflammatory PG fragments, but in smaller amounts than those from . Read More

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http://dx.doi.org/10.3389/fmicb.2019.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365954PMC
January 2019

Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report.

Diagn Pathol 2019 Feb 11;14(1):17. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.

Background: Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), which is considered as the main origin of ovarian HGSC. We reviewed the available literature and discussed about the origin of this rare disease. Read More

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http://dx.doi.org/10.1186/s13000-019-0795-3DOI Listing
February 2019
1 Read

The mechanism of trace acetamiprid-caused reproductive disorders in silkworm, Bombyx mori.

Pest Manag Sci 2019 Feb 10. Epub 2019 Feb 10.

School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, Jiangsu 215123, P.R. China.

Background: Neonicotinoid insecticides are widely used in the prevention and control of pests in agriculture and forestry, but they can also affect the development of nontarget economic insects. In order to determine the effects of trace acetamiprid on the development of reproductive system of silkworm, we studied the gonad development and endogenous hormone metabolism in silkworms exposed to trace acetamiprid.

Result: The silkworm showed mild poisoning symptoms after being exposed to trace acetamiprid (0. Read More

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http://dx.doi.org/10.1002/ps.5373DOI Listing
February 2019
2 Reads

[Diagnostic value of imaging (ultrasonography, doppler, CT, MR, PET-CT) for the diagnosis of a suspicious ovarian mass and staging of ovarian, tubal or primary peritoneal cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Jan 24. Epub 2019 Jan 24.

Service de radiologie, université Paris Descartes Sorbonne Paris Cité, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, Inserm UMR-S970, Cardiovascular Research Center - PARCC, 56, rue Leblanc, 75015 Paris, France.

Transvaginal ultrasound is the first-line examination allowing characterizing 80 to 90% of adnexal masses (LP1). If performed by an expert, a subjective analysis is optimal. If performed by a non-expert, combining the use of Simple Rules with subjective analysis can achieve the diagnostic performance of an expert (LP1). Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.012DOI Listing
January 2019
1 Read

Effect of niraparib on cardiac repolarization in patients with platinum-sensitive, recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.

Cancer Chemother Pharmacol 2019 Jan 24. Epub 2019 Jan 24.

TESARO, Inc, Waltham, MA, USA.

Purpose: Anticancer drugs may cause cardiovascular toxicities, including QT interval prolongation. Niraparib, a potent and selective once-daily oral poly (ADP-ribose) polymerase inhibitor, is approved as a maintenance therapy in platinum-sensitive recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC). Here, we present the effects of niraparib on cardiac repolarization, and the correlation between changes in baseline QT interval corrected by Fridericia's formula (ΔQTcF) and niraparib plasma concentrations. Read More

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http://dx.doi.org/10.1007/s00280-019-03774-wDOI Listing
January 2019

Dose-dense cisplatin with gemcitabine for relapsed platinum-resistant ovarian cancer.

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

The Christie NHS Foundation Trust, Manchester, UK

Introduction: Standard of care treatment for women who develop relapsed ovarian cancer includes sequential platinum- and/or paclitaxel-based chemotherapy, with reducing disease-free intervals. Once platinum resistance develops, treatment options become limited and dose-dense regimens may be offered. We report the efficacy and safety of dose-dense cisplatin with gemcitabine chemotherapy for relapsed platinum-resistant ovarian cancer. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000067DOI Listing
January 2019

Ovarian cancer: screening and future directions.

Int J Gynecol Cancer 2019 Jan;29(1):195-200

Levine Cancer Institute, Charlotte, North Carolina, USA.

Ovarian cancer carries a lifetime risk of approximately 2% for women and is the leading cause of death from any gynecologic malignancy. Currently, no screening program for ovarian cancer exists for the general population in the UK. This review focuses on the evidence surrounding the efficacy of current markers and discusses future improvements in screening for this disease. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000016
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http://dx.doi.org/10.1136/ijgc-2018-000016DOI Listing
January 2019
6 Reads

Phase I study of intravenous oxaliplatin and intraperitoneal docetaxel in recurrent ovarian cancer.

Int J Gynecol Cancer 2019 Jan;29(1):147-152

University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Introduction: Intraperitoneal (IP) chemotherapy improves survival in ovarian cancer but its use has been limited by toxicity with cisplatin-based regimens. The primary objective of this study was to define the maximum tolerated dose and dose-limiting toxicity of intravenous (IV) oxaliplatin and IP docetaxel in women with recurrent ovarian, fallopian tube or peritoneal cancer. Secondary objectives were response rate, time to progression, symptom interference with quality of life, and pharmacokinetics. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000055
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http://dx.doi.org/10.1136/ijgc-2018-000055DOI Listing
January 2019
6 Reads

Efficacy and safety of niraparib as maintenance treatment in older patients (≥ 70 years) with recurrent ovarian cancer: Results from the ENGOT-OV16/NOVA trial.

Gynecol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Dana-Farber Cancer Institute, Boston, MA, USA.

Objective: To analyze the safety and efficacy of niraparib in patients aged ≥70 years with recurrent ovarian cancer in the ENGOT-OV16/NOVA trial.

Methods: The trial enrolled 2 independent cohorts with histologically diagnosed recurrent ovarian, fallopian tube, or peritoneal cancer who responded to platinum rechallenge, on the basis of germline breast cancer susceptibility gene mutation (gBRCAmut) status. Patients were randomized 2:1 to receive niraparib (300 mg) or placebo once daily until disease progression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183147
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http://dx.doi.org/10.1016/j.ygyno.2018.12.009DOI Listing
January 2019
8 Reads

Xanthogranulomatous Oophoritis: A Rare Case Report.

Iran J Pathol 2018 12;13(3):372-376. Epub 2018 Sep 12.

Dept. of Pathology, Dayanand Medical College and Hospital, Ludhiana, India.

Xanthogranulomatous oophoritis is an uncommon, non-neoplastic, chronic process in which the affected organ is destroyed by massive cellular infiltration of foamy histiocytes admixed with multinucleated giant cells, plasma cells, fibroblasts, neutrophils, and foci of necrosis. The etiology of this entity is unknown, but it shares histopathological findings similar to those of xanthogranulomatous change occurring in various organs, including the gallbladder and kidney. The current case was a 20-year-old female presenting with a tubo-ovarian mass with suspicion of malignancy on clinicoradiological findings and final diagnosis of xanthogranulomatous oophritis established on histopathology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322522PMC
September 2018

TRPV4 is involved in levonorgestrel-induced reduction in oviduct ciliary beating.

J Pathol 2019 Jan 10. Epub 2019 Jan 10.

International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Previous studies revealed the increasing risk of tubal pregnancy following failure of levonorgestrel (LNG)-induced emergency contraception, which was attributed to the reduced ciliary motility in response to LNG. However, understanding of the mechanism of LNG-induced reduction in the ciliary beat frequency (CBF) is limited. The transient receptor potential vanilloid (TRPV) 4 channel is located widely in the female reproductive tract and generates an influx of Ca following its activation under normal physiological conditions, which regulates the CBF. Read More

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http://dx.doi.org/10.1002/path.5233DOI Listing
January 2019
7 Reads
7.429 Impact Factor

Trials in progress: IMagyn050/GOG 3015/ENGOT-OV39. A Phase III, multicenter, randomized study of atezolizumab versus placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with newly-diagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer.

Int J Gynecol Cancer 2019 Jan 10. Epub 2019 Jan 10.

IRCCS National Cancer Institute "Fondazione G. Pascale" Naples, Napoli, Italy.

Background: There is mounting pre-clinical and clinical evidence that combinations of immunotherapy, specifically programed cell death-1 (PD-1) inhibition, with chemotherapy and anti-angiogenesis agents, such as bevacizumab, result in markedly improved outcomes across a variety of tumor types including endometrial cancer, renal cell cancer, and non-small cell lung cancer. IMagyn050/GOG 3015/ENGOT-OV39 is the first, randomized, phase III trial to evaluate the potential impact of this combination on both progression-free survival and overall survival in patients presenting with advanced epithelial ovarian cancer.

Primary Objective: The primary objective is to evaluate the efficacy of atezolizumab versus placebo in combination with paclitaxel + carboplatin + bevacizumab for front-line treatment of ovarian cancer among all patients and those with PD-L1+ tumors. Read More

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000071
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http://dx.doi.org/10.1136/ijgc-2018-000071DOI Listing
January 2019
11 Reads

Solitary CNS Metastasis on Initial Presentation of High Grade Serous Carcinoma of the Fallopian Tube.

Case Rep Obstet Gynecol 2018 5;2018:6930986. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

A 68-year-old woman presented with a three-week history of confusion and anomic aphasia. Imaging of her head demonstrated a single large left frontal mass. Pathology revealed metastatic adenocarcinoma of Müllerian origin. Read More

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http://dx.doi.org/10.1155/2018/6930986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304521PMC
December 2018
1 Read

Intravasation Affects the Diagnostic Image Quality of Transvaginal 4-Dimensional Hysterosalpingo-Contrast Sonography With SonoVue.

J Ultrasound Med 2018 Dec 31. Epub 2018 Dec 31.

Department of Ultrasonography, Guangdong Second Provincial General Hospital, Guangdong, China.

Objectives: We aim to retrospectively analyze the diagnostic image quality of transvaginal 4-dimensional hysterosalpingo-contrast sonography from infertile patients and determine the significant influencing factors.

Methods: A total of 445 patients visiting infertility clinics were included in the study, of which 167 were primary infertile and 278 were secondary infertile. The factors were recorded, including age; examination time; infertility type; history of pelvic inflammatory disease, pelvic surgery, intrauterine surgery, and ectopic pregnancy; endometrial thickness; uterine position; ovarian position; 2-dimensional image quality; intravasation quantity, position, and time; balloon volume; and the dosage of contrast agent or the sterile saline solution. Read More

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http://dx.doi.org/10.1002/jum.14914DOI Listing
December 2018
1 Read

CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression.

Cancer Med 2019 Jan 18;8(1):351-362. Epub 2018 Dec 18.

Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji'nan, China.

TP53 mutation is considerably common in advanced high-grade serous ovarian cancer (HGSOC) and significantly associated with a poor prognosis. In this study, we investigated the role of Cyclin G1 (CCNG1), a target gene of wild-type TP53 (P53wt), in HGSOC and the possible regulatory mechanism between TP53 mutant (P53mt) and CCNG1 in the progression of HGSOC. High expression level of CCNG1 was found in 61. Read More

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http://dx.doi.org/10.1002/cam4.1812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346265PMC
January 2019
1 Read

Pathogenesis of and the Host Defense in Ascending Infections of Human Fallopian Tube.

Front Immunol 2018 21;9:2710. Epub 2018 Nov 21.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.

is an obligate human pathogen that causes mucosal surface infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva. Asymptomatic or unnoticed infections in the lower reproductive tract of women can lead to serious, long-term consequences if these infections ascend into the fallopian tube. The damage caused by gonococcal infection and the subsequent inflammatory response produce the condition known as pelvic inflammatory disease (PID). Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02710
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http://dx.doi.org/10.3389/fimmu.2018.02710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258741PMC
November 2018
6 Reads

Cytology of the fallopian tube: A screening model for high-grade serous carcinoma.

Cytojournal 2018 12;15:28. Epub 2018 Nov 12.

Address: Department of Medical and Surgical Gynecology, Mayo Clinic, Jacksonville, FL, USA.

Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Read More

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http://www.cytojournal.com/text.asp?2018/15/1/28/245215
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http://dx.doi.org/10.4103/cytojournal.cytojournal_58_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243852PMC
November 2018
13 Reads

Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: Analysis of KEYNOTE-028.

Gynecol Oncol 2019 02 3;152(2):243-250. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Objective: To evaluate safety, tolerability, and antitumor activity of pembrolizumab monotherapy in patients with programmed death ligand 1 (PD-L1)-expressing advanced ovarian cancer enrolled in the multicohort, phase Ib KEYNOTE-028 trial.

Methods: Key inclusion criteria were age ≥18 years; advanced ovarian epithelial, fallopian tube, or primary peritoneal carcinoma; failure of previous therapy; and tumor PD-L1 positivity. Patients received pembrolizumab (10 mg/kg every 2 weeks) for ≤24 months or until disease progression/intolerable toxicity. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.11.017DOI Listing
February 2019
2 Reads

The fallopian tube, "precursor escape" and narrowing the knowledge gap to the origins of high-grade serous carcinoma.

Gynecol Oncol 2019 02 30;152(2):426-433. Epub 2018 Nov 30.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, United States of America. Electronic address:

Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183145
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http://dx.doi.org/10.1016/j.ygyno.2018.11.033DOI Listing
February 2019
8 Reads

Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases.

J Comp Pathol 2018 Nov 19;165:13-22. Epub 2018 Oct 19.

Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertagstrase 15, Germany. Electronic address:

Disorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 full post-mortem examinations of intact female pet guinea pigs and 64 female genital tract biopsies examined over a 22. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.001DOI Listing
November 2018
1 Read

Back to the Future? The Fallopian Tube, Precursor Escape and a Dualistic Model of High-Grade Serous Carcinogenesis.

Cancers (Basel) 2018 Nov 28;10(12). Epub 2018 Nov 28.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Beginning with the discovery of the -associated ovarian cancer susceptibility genes and subsequent detailed examination of risk-reducing salpingo-oophorectomy (RRSO) specimens, a new paradigm of ovarian carcinogenesis has unfolded with attention to the distal fallopian tube. The primary focus has been an early cancer or neoplasm in the fallopian tube which is seen in virtually all incidentally discovered high-grade serous cancers in asymptomatic women. This high-frequency of tubal involvement in early serous neoplasm (usually in the form of serous tubal intraepithelial carcinoma-STIC) has galvanized attention to this organ as a primary source of this disease. Read More

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http://dx.doi.org/10.3390/cancers10120468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316244PMC
November 2018
1 Read

The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer.

Gynecol Oncol 2019 02 22;152(2):228-234. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology/Section of Gynecologic Oncology/Center for Integrated Science, University of Chicago, Chicago, IL 60637, United States of America. Electronic address:

Objective: It is unclear if the types of surgical procedures performed on long-term survivors (LTS) of high-grade serous ovarian carcinoma (HGSOC) contribute to prolonged survival. In this case-control study we review the surgical procedures performed on LTS and describe their individual longitudinal disease courses.

Methods: Women with FIGO stage III-IV high-grade serous cancer of the ovary, fallopian tube or peritoneum were selected from the University of Chicago ovarian cancer database. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.11.007DOI Listing
February 2019
8 Reads

Current First-line Therapy for Ovarian Cancer: A Comprehensive Review.

Obstet Gynecol Surv 2018 Nov;73(11):650-657

Assistant Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.

Importance: Ovarian, fallopian tube, and primary peritoneal cancers constitute the deadliest gynecologic malignancies. After primary cytoreductive surgery, there are several standard first-line cytotoxic treatments for providers to consider. Newer molecular targeted therapies are becoming more common and may have a role as first-line therapy in the future. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000613DOI Listing
November 2018
12 Reads

Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma.

Diagn Pathol 2018 Nov 14;13(1):87. Epub 2018 Nov 14.

Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 20032, China.

Background: Regulated in development and DNA damage response (REDD1), a gene responding to hypoxia or multiple DNA damage events, was recently implicated in cancer development and progression. Previously, in vivo and in vitro experiments indicated that REDD1 functions as an oncogene in ovarian cancer cells. However, the role of REDD1 in cancer cell migration and invasion and in clinical significance of prognostic values is not examined in detail. Read More

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http://dx.doi.org/10.1186/s13000-018-0754-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236897PMC
November 2018
14 Reads

Comparison of the prevalence of adhesions at the time of diagnostic laparoscopy for infertility between patient who had open myomectomy and those who had no previous pelvic-abdominal surgery or pelvic inflammatory disease.

Niger J Clin Pract 2018 Nov;21(11):1415-1421

Department of Obstetrics and Gynecology, Asokoro District Hospital, Abuja, Nigeria.

Objective: The aim of this study is to determine the prevalence and patterns of adhesions in infertile women with prior open myomectomy compared with women without prior pelvic-abdominal surgery.

Methods: A nested case-control study of infertile women who had diagnostic laparoscopy after open myomectomy between January 2008 and June 2015 in Life Institute for Endoscopy Limited, Nnewi Nigeria, was conducted. At diagnostic laparoscopy, the presence, site, and quality (density) of adhesions was noted and recorded. Read More

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http://dx.doi.org/10.4103/njcp.njcp_39_17DOI Listing
November 2018
1 Read

Ocular Toxicity of Mirvetuximab.

Cornea 2019 Feb;38(2):229-232

Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.

Purpose: To report the clinical features and outcomes of corneal toxicity following mirvetuximab soravtansine therapy.

Methods: Five patients who were treated with mirvetuximab soravtansine were evaluated in our hospital for ocular symptoms during a period of 5 months between December 2017 and April 2018. A complete ophthalmologic examination, including anterior segment infrared reflectance (AS-IR) and anterior segment optical coherence tomography (AS-OCT), was performed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001805DOI Listing
February 2019
9 Reads

Laparoscopy versus laparotomy for the management of early stage endometrial cancer.

Cochrane Database Syst Rev 2018 10 31;10:CD006655. Epub 2018 Oct 31.

Gynaecological Oncology, Princess Alexandra Wing, Royal Cornwall Hospital, Truro, UK, TR1 3LJ.

Background: This is an update of a previous Cochrane Review published in 2012, Issue 9.Surgery for endometrial cancer (hysterectomy with removal of both fallopian tubes and ovaries) is performed through laparotomy. It has been suggested that the laparoscopic approach is associated with a reduction in operative morbidity. Read More

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http://doi.wiley.com/10.1002/14651858.CD006655.pub3
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http://dx.doi.org/10.1002/14651858.CD006655.pub3DOI Listing
October 2018
11 Reads

Genital Tract Pathology in Female Pet Rabbits (Oryctolagus cuniculus): a Retrospective Study of 854 Necropsy Examinations and 152 Biopsy Samples.

J Comp Pathol 2018 Oct 7;164:17-26. Epub 2018 Sep 7.

Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertagstrase 15, Berlin, Germany. Electronic address:

Genital tract disorders, especially uterine disorders, are the most common conditions of the female pet rabbit (Oryctolagus cuniculus); however, there have been few large studies of diseases of the female genital tract of this species. The present study examined diseases of the ovaries, Fallopian tubes, uterus and vagina, retrospectively over a period of 22 years, and included 854 full post-mortem examinations of female pet rabbits and 152 female genital tract biopsy samples. The age distribution of uterine neoplasia, endometrial hyperplasia and uterine inflammation was determined in the post-mortem cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219975183015
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http://dx.doi.org/10.1016/j.jcpa.2018.08.003DOI Listing
October 2018
7 Reads

Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141,460 Individuals.

J Clin Med 2018 Oct 24;7(11). Epub 2018 Oct 24.

School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

Endometriosis occurs when endometrial tissue exists outside the uterine cavity. The presence of ectopic endometrial tissue and resultant inflammation cause serious symptoms, including chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Pelvic inflammatory disease is caused by the ascension of pathogenic bacteria from the vagina to the uterus, Fallopian tubes, and ovaries. Read More

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http://www.mdpi.com/2077-0383/7/11/379
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http://dx.doi.org/10.3390/jcm7110379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262473PMC
October 2018
10 Reads

Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer.

N Engl J Med 2018 12 21;379(26):2495-2505. Epub 2018 Oct 21.

From the Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (K.M.); University of Milan-Bicocca, European Institute of Oncology Istituto di Ricovero e Cura a Carattere Scientifico, Milan (N.C.), and Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica, Rome (G.S.) - both in Italy; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (B.-G.K.); Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona (A. Oaknin), and M.D. Anderson Cancer Centre Madrid, Madrid (A.G.-M.) - both in Spain; University of New South Wales Clinical School, Prince of Wales Hospital, Randwick, Australia (M.F.); St. Petersburg City Oncology Dispensary, St. Petersburg, Russia (A. Lisyanskaya); Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens, Paris (A.F., A. Leary), Institut Bergonié, Comprehensive Cancer Center, Bordeaux (A.F.), and Gustave-Roussy Cancer Campus, Villejuif (A. Leary) - all in France; the Netherlands Cancer Institute, Amsterdam (G.S.S.); Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh (C.G.), the Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London (S.B.), and AstraZeneca, Cambridge (R.B.) - all in the United Kingdom; Princess Margaret Cancer Centre, Toronto (A. Oza); Memorial Sloan Kettering Cancer Center, New York (C.A.); Froedtert and the Medical College of Wisconsin, Milwaukee (W.B.); Women and Infants Hospital, Providence, RI (C.M., P.D.); Dana-Farber Cancer Institute, Boston (J.L.); and AstraZeneca, Gaithersburg, MD (E.S.L.).

Background: Most women with newly diagnosed advanced ovarian cancer have a relapse within 3 years after standard treatment with surgery and platinum-based chemotherapy. The benefit of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor olaparib in relapsed disease has been well established, but the benefit of olaparib as maintenance therapy in newly diagnosed disease is uncertain.

Methods: We conducted an international, randomized, double-blind, phase 3 trial to evaluate the efficacy of olaparib as maintenance therapy in patients with newly diagnosed advanced (International Federation of Gynecology and Obstetrics stage III or IV) high-grade serous or endometrioid ovarian cancer, primary peritoneal cancer, or fallopian-tube cancer (or a combination thereof) with a mutation in BRCA1, BRCA2, or both ( BRCA1/2) who had a complete or partial clinical response after platinum-based chemotherapy. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1810858
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http://dx.doi.org/10.1056/NEJMoa1810858DOI Listing
December 2018
21 Reads

Review of Endometriosis Diagnosis through Advances in Biomedical Engineering.

Crit Rev Biomed Eng 2018 ;46(3):277-288

All Saints University, St. Vincent & the Grenadines.

Endometriosis is characterized as the ectopic presence of endometrium in various locations within the abdominal cavity, such as the fallopian tube, the pouch of Douglas, the ovaries, outside the ovaries, and more. The inner lining of the uterus, endometrium, is a dynamic tissue that undergoes morphological and functional changes cyclically. The proliferation of endometrial cells during menstruation is influenced by increasing circulating estrogen levels. Read More

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http://dx.doi.org/10.1615/CritRevBiomedEng.2018027414DOI Listing
January 2018
15 Reads

A phase II evaluation of elesclomol sodium and weekly paclitaxel in the treatment of recurrent or persistent platinum-resistant ovarian, fallopian tube or primary peritoneal cancer: An NRG oncology/gynecologic oncology group study.

Gynecol Oncol 2018 12 8;151(3):422-427. Epub 2018 Oct 8.

Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, NY, USA. Electronic address:

Objective: Preclinical data suggest elesclomol increases oxidative stress and enhances sensitivity to cytotoxic agents. The objective of this prospective multicenter phase 2 trial was to estimate the activity of IV elesclomol plus weekly paclitaxel in patients with platinum-resistant recurrent ovarian, tubal or peritoneal cancer through the frequency of objective tumor responses (ORR).

Methods: Patients with measurable disease, acceptable organ function, performance status ≤ 2, and one prior platinum containing regimen were eligible. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183128
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http://dx.doi.org/10.1016/j.ygyno.2018.10.001DOI Listing
December 2018
9 Reads

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer.

Cochrane Database Syst Rev 2018 Oct 8;10:CD012567. Epub 2018 Oct 8.

Department of Gynaecological Oncology, UMC Utrecht Cancer Center, Utrecht, Netherlands, 3508 GA.

Background: Ovarian cancer is the leading cause of death from gynaecological cancer in developed countries. Surgery and chemotherapy are considered its mainstay of treatment and the completeness of surgery is a major prognostic factor for survival in these women. Currently, computed tomography (CT) is used to preoperatively assess tumour resectability. Read More

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http://doi.wiley.com/10.1002/14651858.CD012567.pub2
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http://dx.doi.org/10.1002/14651858.CD012567.pub2DOI Listing
October 2018
5 Reads

A rare case of large pyosalpinx in an elderly patient with well-controlled type 2 diabetes mellitus: a case report.

J Med Case Rep 2018 Oct 6;12(1):286. Epub 2018 Oct 6.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

Background: Pyosalpinx, which is one of the pelvic inflammatory diseases, is usually observed in young women; it is rarely found in older women. Possible causative agents are thought to be Chlamydia trachomatis and Neisseria gonorrhea in addition to some Enterobacteriaceae. On the other hand, type 2 diabetes is a disease with a lot of complications such as hyperglycemia, inflammation, and immune disorders. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1841-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173840PMC
October 2018
14 Reads

Time to chemotherapy in ovarian cancer: Compliance with ovarian cancer quality indicators at a National Cancer Institute-designated Comprehensive Cancer Center.

Gynecol Oncol 2018 12 30;151(3):501-505. Epub 2018 Sep 30.

Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America.

Objective: To assess compliance with, and outcomes related to, the Society of Gynecologic Oncology quality measure in ovarian cancer to administer chemotherapy within 42 days of cytoreductive surgery in patients with epithelial ovarian/fallopian tube/peritoneal cancer.

Methods: Institutional ovarian cancer database was evaluated for compliance with the quality measure to administer chemotherapy within 42 days of cytoreductive surgery. The influence of chemotherapy timing on the risk of death was evaluated, and factors related to the timing of chemotherapy after surgery was assessed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183123
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http://dx.doi.org/10.1016/j.ygyno.2018.09.014DOI Listing
December 2018
7 Reads

Higher Prevalence of Endometrial Polyps in Patients with Fallopian Tube Obstruction: A Case-control Study.

J Minim Invasive Gynecol 2018 Sep 28. Epub 2018 Sep 28.

Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China (Drs. Sun and Bai). Electronic address:

Study Objective: To study the association between endometrial polyps and fallopian tube patency diagnosed by hysteroscopy, conventional histology, and 4-dimensional (4D) hysterosalpingo-contrast sonography (HyCoSy).

Design: A case-control study (Canadian Task Force classification II-2).

Setting: A university hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15534650183124
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http://dx.doi.org/10.1016/j.jmig.2018.07.024DOI Listing
September 2018
5 Reads

Fallopian tube microbiota: evidence beyond DNA.

Future Microbiol 2018 09 26;13:1355-1361. Epub 2018 Sep 26.

The Wesley Hospital, Auchenflower, Queensland, 4066, Australia.

Aim: To determine whether cultivation-dependent and -independent analyses identifying fallopian tube bacteria were associated with visually observable microbial cells in situ using scanning electron microscopy.

Patients: Fallopian tubes were collected from pre- and postmenopausal women undergoing salpingectomies for benign disease or as prophylaxis.

Materials & Methods: Fresh fallopian tube samples were processed for scanning electron microscopy to characterize fallopian tube ultrastructure. Read More

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https://www.futuremedicine.com/doi/10.2217/fmb-2018-0118
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http://dx.doi.org/10.2217/fmb-2018-0118DOI Listing
September 2018
8 Reads

Bilateral salpingectomy to reduce the risk of ovarian/fallopian/peritoneal cancer in women at average risk: a position statement of the Korean Society of Obstetrics and Gynecology (KSOG).

Obstet Gynecol Sci 2018 Sep 7;61(5):542-552. Epub 2018 Sep 7.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Based on the current understanding of a preventive effect of bilateral salpingectomy on ovarian/fallopian/peritoneal cancers, the Korean Society of Obstetrics and Gynecology, Korean Society of Gynecologic Endocrinology, Korean Society of Gynecologic Oncology, Korean Society of Maternal Fetal Medicine, and Korean Society for Reproductive Medicine support the following recommendations: • Women scheduled for hysterectomy for benign gynecologic disease should be informed that bilateral salpingectomy reduces the risk of ovarian/fallopian/peritoneal cancer, and they should be counseled regarding this procedure at the time of hysterectomy. • Although salpingectomy is generally considered as a safe procedure in terms of preserving ovarian reserve, there is a lack of evidences representing its long-term outcomes. Therefore, patients should be informed about the minimal potential of this procedure for decreasing ovarian reserve. Read More

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http://dx.doi.org/10.5468/ogs.2018.61.5.542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137013PMC
September 2018
2 Reads

Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study.

J Pathol Clin Res 2019 Jan 22;5(1):25-39. Epub 2018 Oct 22.

Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Breast cancer metastasis to gynaecological organs is an understudied pattern of tumour spread. We explored clinico-pathological and molecular features of these metastases to better understand whether this pattern of dissemination is organotropic or a consequence of wider metastatic dissemination. Primary and metastatic tumours from 54 breast cancer patients with gynaecological metastases were analysed using immunohistochemistry, DNA copy-number profiling, and targeted sequencing of 386 cancer-related genes. Read More

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http://dx.doi.org/10.1002/cjp2.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317061PMC
January 2019
12 Reads

Diagnostic and prognostic value of HE4 in female patients with primary peritoneal carcinoma.

Int J Biol Markers 2018 Sep 21:1724600818796595. Epub 2018 Sep 21.

Department of Clinical Laboratory, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China.

Background: HE4 is a useful tumor marker for the diagnosis of ovarian, endometrial, and fallopian tube carcinoma.

Aim: The aim of our study was to investigate the value of serum HE4 compared with CA125 in the diagnosis of primary peritoneal carcinoma and the estimation of treatment response and recurrence.

Methods: Serum HE4 and CA125 concentrations were measured in both primary peritoneal carcinoma patients and benign gynecological disease controls. Read More

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http://journals.sagepub.com/doi/10.1177/1724600818796595
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http://dx.doi.org/10.1177/1724600818796595DOI Listing
September 2018
10 Reads

Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study.

Cancer Prev Res (Phila) 2018 Nov 19;11(11):697-706. Epub 2018 Sep 19.

Department of Pathology, Johns Hopkins University School of Medicine.

The prognosis of women diagnosed with invasive high-grade serous ovarian carcinoma (HGSC) is poor. More information about serous tubal intraepithelial carcinoma (STIC) and serous tubal intraepithelial lesions (STIL), putative precursor lesions of HGSC, could inform prevention efforts. We conducted a multicenter study to identify risk/protective factors associated with STIC/STILs and characterize p53 signatures in the fallopian tube. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0009DOI Listing
November 2018
2 Reads

Perioperative epidural use and survival outcomes in patients undergoing primary debulking surgery for advanced ovarian cancer.

Gynecol Oncol 2018 11 2;151(2):287-293. Epub 2018 Sep 2.

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America; Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, United States of America. Electronic address:

Objective: Epidurals are associated with improved outcomes in some solid tumors, presumably due to their effect on surgical stress response. There are limited data on the prognostic significance of epidural anesthesia in patients undergoing primary debulking surgery (PDS) for advanced ovarian cancer. We sought to assess the impact of epidural anesthesia on the survival outcomes of patients undergoing PDS for advanced ovarian cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183115
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http://dx.doi.org/10.1016/j.ygyno.2018.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214778PMC
November 2018
17 Reads

Sarcoidosis of the fallopian tube: A rare case study with confirmed Propionibacterium acnes infection.

J Obstet Gynaecol Res 2019 Jan 3;45(1):235-238. Epub 2018 Sep 3.

Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan.

Sarcoidosis is a systemic granulomatous disease that is most commonly manifested in the pulmonary system. Though the entire etiology of sarcoidosis remains unknown, it has been reported that Propionibacterium acnes (P. acnes) has been isolated from sarcoid lesions. Read More

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http://dx.doi.org/10.1111/jog.13800DOI Listing
January 2019
14 Reads

Randomized phase II trial of bevacizumab plus everolimus versus bevacizumab alone for recurrent or persistent ovarian, fallopian tube or peritoneal carcinoma: An NRG oncology/gynecologic oncology group study.

Gynecol Oncol 2018 11 31;151(2):257-263. Epub 2018 Aug 31.

Gynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States of America. Electronic address:

Purpose: Bevacizumab (BV) monotherapy leads to compensatory upregulation of multiple signaling pathways, resulting in mTOR activation. We evaluated combining BV and everolimus (EV), an mTOR kinase inhibitor, to circumvent BV-resistance in women with recurrent or persistent ovarian, fallopian tube or primary peritoneal cancer (OC).

Patients And Methods: Eligible OC patients had measurable (RECIST1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183115
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http://dx.doi.org/10.1016/j.ygyno.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350932PMC
November 2018
13 Reads

IS "OVARIAN" CANCER A MISNOMER? EXPLORING OVARIAN CANCER ORIGINS IN THE MOUSE.

Authors:
Kathleen R Cho

Trans Am Clin Climatol Assoc 2018 ;129:40-47

ANN ARBOR, MICHIGAN.

Ovarian cancer is a generic term that encompasses several different tumor types. The most common and lethal type is known as high-grade serous carcinoma. The cellular origin of high-grade serous carcinoma has been debated for many years, but recent studies suggest that many, if not most, arise from epithelium in the fallopian tube rather than from the ovarian surface epithelium. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116583PMC
December 2018
2 Reads

Prognostic factors of primary fallopian tube carcinoma.

Contemp Oncol (Pozn) 2018 9;22(2):99-104. Epub 2018 Apr 9.

Department of Obstetrics and Gynecology, Erzincan University, School of Medicine, Turkey.

Aim Of The Study: Fallopian tube cancer is very rare in the literature and so there are not enough data about the therapeutic approaches. The approaches are generally determined in accordance with the data obtained from ovarian cancer. Many prognostic factors have been investigated in an effort to better estimate patient outcome. Read More

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http://dx.doi.org/10.5114/wo.2017.69590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103229PMC
April 2018
5 Reads

Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer.

Int J Mol Sci 2018 Aug 24;19(9). Epub 2018 Aug 24.

Division of Molecular Oncology, Department of Translational Research, IRCCS CRO Aviano-National Cancer Institute, Via Franco Gallini, 2 33081 Aviano PN, Italy.

High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Read More

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http://www.mdpi.com/1422-0067/19/9/2512
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http://dx.doi.org/10.3390/ijms19092512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163198PMC
August 2018
2 Reads

[Histopathology and clinical aspects of extrauterine pregnancy].

Pathologe 2018 Sep;39(5):431-444

Klinik und Poliklinik für Frauenheilkunde, Klinikums rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.

Ectopic pregnancies are the main sources of pregnancy-related morbidity and mortality in the first trimester. They are usually located in the ampullary part of the fallopian tube and the incidence increases in the setting of assisted reproductive techniques, older age at the time of the first pregnancy, and prior adnexal procedures. The clinical aspects and diagnostic challenges of an ectopic pregnancy for the pathologist are to be outlined. Read More

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http://dx.doi.org/10.1007/s00292-018-0471-5DOI Listing
September 2018
12 Reads

Uterine Lipoleiomyoma and Lipoma: A Rare Unique Case Report with Review of Literature.

Int J Appl Basic Med Res 2018 Jul-Sep;8(3):193-195

Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India.

Uterine lipoleiomyoma and pure lipoma are uncommon and extremely rare benign lipomatous tumors. Reported incidence is 0.03%-0. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_119_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082001PMC
August 2018
3 Reads