4,209 results match your criteria Fallopian Tube Disorders


An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer.

Gynecol Oncol Rep 2022 Aug 10;42:101017. Epub 2022 Jun 10.

University of North Carolina at Chapel Hill, Department of Medicine, Center for Gastrointestinal Biology and Disease, United States.

Objective: The microbiome of the female upper reproductive tract (URT) has not been characterized. We hypothesize that distinct bacterial species may be identified in different areas of the URT in women with or without ovarian cancers.

Methods: Postmenopausal women scheduled for salpingooophorectomy were prospectively identified. Read More

View Article and Full-Text PDF

Phase I trial of daily subcutaneous SPL-108 injections in combination with paclitaxel in patients with platinum resistant CD44+ advanced ovarian epithelial cancer.

Int J Gynecol Cancer 2022 Jun 24. Epub 2022 Jun 24.

City of Hope National Medical Center, Duarte, California, USA

Objective: Preclinical evidence and early clinical trials have demonstrated the activity of SPL-108, a targeted agent that inhibits CD44 mediated induction of multidrug resistance specifically to paclitaxel and platinum agents. We conducted a phase I, open label, dose escalation study of the safety and tolerability of the combination of SPL-108 with weekly paclitaxel in patients with platinum resistant CD44+ ovarian, primary peritoneal, or fallopian tube cancer.

Methods: Patients with platinum resistant histologically proven epithelial ovarian, primary peritoneal, or fallopian tube cancers and measurable disease according to RECIST (Response Evaluation Criteria in Solid Tumours) version 1. Read More

View Article and Full-Text PDF

Is There Still a Place for Reconstructive Surgery in Distal Tubal Disease?

J Clin Med 2022 Jun 8;11(12). Epub 2022 Jun 8.

Center for Diagnostic Medical Sonography, Litewska 4/4, 35-302 Rzeszow, Poland.

Tubal diseases account for 25-40% of female factor infertility. Mainly, they involve the distal part of the fallopian tube, and hydrosalpinx is the most severe manifestation. Usually, the management decision is made between reconstructive surgery and ART, depending on the severity of the tubal damage, patient age, ovarian reserve, and seminogram, as well as financial, religious, ethical, and psychological factors. Read More

View Article and Full-Text PDF

A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility.

Diagnostics (Basel) 2022 Jun 2;12(6). Epub 2022 Jun 2.

Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, Italy.

Tubal factor is an important contributor to female infertility, and the current diagnostic approaches cannot correctly identify many subtle causes of tubal dysfunction. While it is known that the most common cause of tubal factor infertility is pelvic inflammatory disease (PID), creating critical alterations of the tubal epithelium, little attention has been devoted to understanding the tubal modifications caused by the resident microbial population and their interaction with the surrounding tubal epithelium. Furthermore, most of these samples are obtained by traumatic procedures such as direct sampling during laparoscopy using a cytobrush. Read More

View Article and Full-Text PDF

The Double Engines and Single Checkpoint Theory of Endometriosis.

Biomedicines 2022 Jun 14;10(6). Epub 2022 Jun 14.

Center for Prevention and Therapy of Gynecological Cancers, Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Endometriosis is a chronic disease characterized by the ectopic localization of the endometrial tissue in the peritoneal cavity. Consequently, it causes local pathological changes and systemic symptoms, affecting at least one in every ten women. This disease is difficult to diagnose early, it is prone to dissemination, is difficult to eradicate, tends to recur, and is regarded as "a cancer of no kill". Read More

View Article and Full-Text PDF

Association of pediatric inguinal hernia contents with patient age and sex.

Pediatr Int 2022 Jan;64(1):e15193

Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Background: Although pediatric inguinal hernia (IH) is a very common disease, systematic reviews of herniated organs are scarce. The current study aims to clarify the contents of pediatric IH using preoperative ultrasonography (US) in association with patient age, sex, and risk for developing irreducible/strangulated hernia.

Methods: The medical records of pediatric IH patients who underwent inguinal US examination prior to surgery between 2014 and 2019 were reviewed. Read More

View Article and Full-Text PDF
January 2022

OVARIO phase II trial of combination niraparib plus bevacizumab maintenance therapy in advanced ovarian cancer following first-line platinum-based chemotherapy with bevacizumab.

Gynecol Oncol 2022 Jun 8. Epub 2022 Jun 8.

Division of Gynecologic Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Objective: To assess safety and efficacy of niraparib + bevacizumab as a first-line maintenance therapy for patients with newly diagnosed advanced ovarian cancer.

Methods: This multicenter, phase II, single-arm, open-label study enrolled adult patients with stage IIIB to IV ovarian, fallopian tube, or primary peritoneal cancer (NCT03326193). Patients were required to have an attempt at debulking surgery and have a complete response, partial response, or no evidence of disease following first-line, platinum-based chemotherapy with ≥3 cycles of bevacizumab. Read More

View Article and Full-Text PDF

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment (ICON8): overall survival results from an open-label, randomised, controlled, phase 3 trial.

Lancet Oncol 2022 Jun 8. Epub 2022 Jun 8.

MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.

Background: Standard-of-care first-line chemotherapy for epithelial ovarian cancer is carboplatin and paclitaxel administered once every 3 weeks. The JGOG 3016 trial reported significant improvement in progression-free and overall survival with dose-dense weekly paclitaxel and 3-weekly (ie, once every 3 weeks) carboplatin. However, this benefit was not observed in the previously reported progression-free survival results of ICON8. Read More

View Article and Full-Text PDF

Ovulation Enhances Intraperitoneal and Ovarian Seedings of High-Grade Serous Carcinoma Cells Originating from the Fallopian Tube: Confirmation in a Bursa-Free Mouse Xenograft Model.

Int J Mol Sci 2022 Jun 1;23(11). Epub 2022 Jun 1.

Center for Prevention and Therapy of Gynecological Cancers, Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.

Recently, new paradigms for the etiology and origin of ovarian high-grade serous carcinoma (HGSC) have emerged. The carcinogens released during ovulation transform fallopian tube epithelial cells, exfoliating and metastasizing to the peritoneal organs, including the ovaries. Solid in vivo evidence of the paradigms in a mouse model is urgently needed but is hampered by the differing tubo-ovarian structures. Read More

View Article and Full-Text PDF

Rare giant female adnexal tumor of probable Wolffian origin: a case report.

J Surg Case Rep 2022 May 27;2022(5):rjac243. Epub 2022 May 27.

Department of Surgery, General Hospital, Sarajevo 71 000, Bosnia and Herzegovina.

Female adnexal tumors of probable Wolffian origin (FATWOs) are extremely rare tumors, with only around 100 cases published worldwide. FATWOs are most frequently found in the broad ligament, but these can also appear in the mesosalpinx, Fallopian tube, ovary, paravaginal region or peritoneum. We present a case of a 68-year-old female with a history of painless abdominal distension and frequent urination, with palpable big abdominal mass. Read More

View Article and Full-Text PDF

Two novel AMHR2 gene variants in monozygotic twins with persistent Müllerian duct syndrome: A case report and functional study.

Mol Genet Genomic Med 2022 Jun 2:e1999. Epub 2022 Jun 2.

Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, China.

Background: Persistent Müllerian duct syndrome (PMDS) is an autosomal recessive congenital abnormality in which Müllerian derivatives, uterus, cervix, upper two-thirds of the vagina, and fallopian tubes persist in otherwise normally virilized males. Mutations in anti-Müllerian hormone (AMH) and AMH receptor type II (AMHR2) genes have been identified as causative. However, functional experimental analysis of AMHR2 or AMH variants that cause PMDS is still lacking. Read More

View Article and Full-Text PDF

Primary Fallopian Tube Carcinoma: An Extremely Rare Gynecological Cancer Misdiagnosed Intraoperatively as Benign Ovarian Neoplasm: A Case Report.

Clin Pract 2022 Apr 22;12(3):253-260. Epub 2022 Apr 22.

Department of Obstetrics and Gynecology, General Hospital in Trikala, Efkli 33, 42100 Trikala, Greece.

Primary fallopian tube carcinoma is very rare. Diagnosis is challenging. The description of our case concerns an asymptomatic 71-year-old patient who came for a routine gynecological examination. Read More

View Article and Full-Text PDF

Primary Fallopian Tube Carcinoma Presenting with a Massive Inguinal Tumor: A Case Report and Literature Review.

Medicina (Kaunas) 2022 Apr 23;58(5). Epub 2022 Apr 23.

Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan.

Primary fallopian tube carcinoma (PFTC) has characteristics similar to those of ovarian carcinoma. The typical course of PFTC metastasis includes peritoneal dissemination and pelvic and paraaortic lymph node metastasis, while inguinal lymph node metastasis is rare. Moreover, the initial presentation of PFTC with an inguinal tumor is extremely rare. Read More

View Article and Full-Text PDF

Metastatic follicular carcinoma arising from struma ovarii.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Obstetrics & Gynaecology, Gynaecological Oncology, KK Women's and Children's Hospital, Singapore.

Struma ovarii (SO) is an uncommon monodermal teratoma predominantly composed of mature thyroid tissue. Approximately 5% of SO are malignant; however, metastases are rare. A single female in her 40s, with a medical history of Graves' disease and bilateral cystectomy 10 years prior for right endometriotic cyst and left SO, presented with an enlarging abdominal mass for 4 months. Read More

View Article and Full-Text PDF

The Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination.

Front Endocrinol (Lausanne) 2022 28;13:886533. Epub 2022 Apr 28.

Experimental Pathology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.

Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is normally diagnosed at late stages, at which point metastasis has already occurred. Throughout disease progression, EOC will encounter various ecosystems and the communication between cancer cells and these microenvironments will promote the survival and dissemination of EOC. The primary tumor is thought to develop within the ovaries or the fallopian tubes, both of which provide a microenvironment with high risk of causing DNA damage and enhanced proliferation. Read More

View Article and Full-Text PDF

Physiological Action of Progesterone in the Nonhuman Primate Oviduct.

Cells 2022 05 3;11(9). Epub 2022 May 3.

Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, 505 NW 185th Ave., Beaverton, OR 97006, USA.

Therapies that target progesterone action hold potential as contraceptives and in managing gynecological disorders. Recent literature reviews describe the role of steroid hormones in regulating the mammalian oviduct and document that estrogen is required to stimulate epithelial differentiation into a fully functional ciliated and secretory state. However, these reviews do not specifically address progesterone action in nonhuman primates (NHPs). Read More

View Article and Full-Text PDF

Vaginal Evisceration of Small Bowel With Extraperitoneal Ileal Resection of the Herniated Loops: A Case Report.

Front Surg 2022 26;9:878760. Epub 2022 Apr 26.

Department of Surgery, Azienda ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.

Introduction: Vaginal evisceration is an extremely rare surgical emergency that can be described as the extrusion of abdominal viscera through a defect or a rupture of the vaginal wall. We reported the case of an acute abdomen due to small bowel evisceration secondary to vaginal vault dehiscence that required combined vaginal-abdominal approach.

Case: We discuss the case of a 72-year-old female who presented to the emergency department for a large prolapse with visible extrusion of the small bowel per vagina. Read More

View Article and Full-Text PDF

variants in p53 signatures and the clonality of STICs in RRSO samples.

J Gynecol Oncol 2022 Mar 21. Epub 2022 Mar 21.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Objective: Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of . Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of high-grade serous carcinoma, whereas the significance of the p53 signature remains unclear. In this study, we investigated the relationship between the p53 signature and the risk of ovarian cancer. Read More

View Article and Full-Text PDF

Efficacy of niraparib by time of surgery and postoperative residual disease status: A post hoc analysis of patients in the PRIMA/ENGOT-OV26/GOG-3012 study.

Gynecol Oncol 2022 Jul 9;166(1):36-43. Epub 2022 May 9.

Grupo Español de Investigación en Cáncer de Ovario (GEICO), the Medical Oncology Department, Clínica Universidad de Navarra, and Program in Solid Tumors, Center for Applied Medical Research (CIMA), Madrid, Spain.

Objective: To evaluate the association between surgical timing and postoperative residual disease status on the efficacy of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer at high risk of recurrence.

Methods: Post hoc analysis of the phase 3 PRIMA/ENGOT-OV26/GOG-3012 (NCT02655016) study of niraparib in patients with newly diagnosed primary advanced ovarian, primary peritoneal, or fallopian tube cancer with a complete/partial response to first-line platinum-based chemotherapy. Progression-free survival (PFS) was assessed by surgical status (primary debulking surgery [PDS] vs neoadjuvant chemotherapy/interval debulking surgery [NACT/IDS]) and postoperative residual disease status (no visible residual disease [NVRD] vs visible residual disease [VRD]) in the intent-to-treat population. Read More

View Article and Full-Text PDF

Fallopian Tube Originating Ovarian Cancer in a 53-Year-Old Postmenopausal Female With Hereditary Breast Cancer (BRCA) Genes: A Case Study.

Cureus 2022 Apr 7;14(4):e23929. Epub 2022 Apr 7.

Obstetrics and Gynecology, New York Institute of Technology College of Osteopathic Medicine (NYITCOM), Old Westbury, USA.

Ovarian cancer is the second most common gynecologic malignancy, but it is the deadliest of the gynecologic cancers. Out of 21,410 new cases of ovarian cancer in the United States in 2021, more than half were fatal. In this case study, a 53-year-old sexually active postmenopausal patient with a family history of breast cancer presented to her gynecologist for an annual exam. Read More

View Article and Full-Text PDF

High risk and low prevalence diseases: Tubo-ovarian abscess.

Am J Emerg Med 2022 Jul 27;57:70-75. Epub 2022 Apr 27.

SAUSHEC, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA. Electronic address:

Introduction: Tubo-ovarian abscess (TOA) is a rare but serious condition that carries with it a high rate of morbidity and even mortality.

Objective: This review highlights the pearls and pitfalls of TOA, including diagnosis, initial resuscitation, and management in the emergency department (ED) based on current evidence.

Discussion: TOA is associated with pelvic inflammatory disease (PID) as well as intrauterine devices, uterine procedures, multiple sexual partners, diabetes mellitus, and immunocompromised states. Read More

View Article and Full-Text PDF

DMM Outstanding Paper Prize 2021 winner: Daniel Bronder.

Authors:
Rachel Hackett

Dis Model Mech 2022 04 3;15(4). Epub 2022 May 3.

The Company of Biologists, Bidder Building, Station Road, Cambridge CB24 9LF, UK.

Disease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Outstanding Paper Prize 2021 is Daniel Bronder, for his paper entitled 'TP53 loss initiates chromosomal instability in fallopian tube epithelial cells' ( Bronder et al., 2021). The prize of £1000 is awarded to the first author of the paper that is judged by the journal's editors to be the most outstanding contribution to the journal that year. Read More

View Article and Full-Text PDF

Fertility Outcome and Safety of Ethiodized Poppy Seed Oil for Hysterosalpingography in 1,053 Infertile Patients: A Real-World Study.

Front Med (Lausanne) 2022 15;9:804494. Epub 2022 Apr 15.

Department of Radiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Objective: Ethiodized poppy seed oil for hysterosalpingography (HSG) is reported to display some therapeutic effect on infertility, but big a sample-size study under real clinical settings is still lacking to verify the speculation. Thus, this real-world study enrolled 1,053 infertile patients who underwent ethiodized poppy seed oil-based HSG to explore its fertility enhancement value.

Method: A total of 1,053 infertile patients who underwent HSG using ethiodized poppy seed oil as the contrast medium were retrospectively analyzed. Read More

View Article and Full-Text PDF

Bilateral Oophorectomy and the Risk of Breast Cancer in BRCA1 Mutation Carriers: a Reappraisal.

Cancer Epidemiol Biomarkers Prev 2022 Apr 27. Epub 2022 Apr 27.

Women's College Hospital, Toronto, ON, Canada.

Background: The lack of consensus on whether bilateral oophorectomy impacts risk of developing breast cancer among BRCA1 mutation carriers might be attributed to various biases, specifically, cancer-induced testing bias due to inclusion of prevalent cases. We conducted two complementary matched case-control analyses to evaluate the association of oophorectomy and BRCA1-breast cancer.

Methods: A research questionnaire was administered every two years to collect information on exposures and disease. Read More

View Article and Full-Text PDF

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy.

Int J Mol Sci 2022 Mar 23;23(7). Epub 2022 Mar 23.

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza 1/3, 02-015 Warsaw, Poland.

Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. Read More

View Article and Full-Text PDF

Pelvic inflammatory disease in pregnancy: a systematic review focusing on perinatal outcomes.

Am J Obstet Gynecol MFM 2022 07 8;4(4):100643. Epub 2022 Apr 8.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA (Dr Berghella). Electronic address:

Background: Pelvic inflammatory disease during pregnancy is a rare and an understudied occurrence with potential negative outcomes.

Objective: This study aimed to evaluate the outcomes of pregnant women with pelvic inflammatory disease with or without pelvic abscesses.

Data Sources: We performed a systematic review of the literature using Ovid MEDLINE, Scopus, CINAHL, and PubMed (including Cochrane) with no time limitations. Read More

View Article and Full-Text PDF

Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment.

Semin Cancer Biol 2022 Apr 5. Epub 2022 Apr 5.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Ovarian cancer encompasses a heterogeneous group of malignancies that involve the ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the field of cancer, the majority of patients with ovarian cancer are still being diagnosed at an advanced stage of the disease due to lack of effective screening tools. The overall survival of these patients has, therefore, not substantially improved over the past decades. Read More

View Article and Full-Text PDF

Computed tomographic enterography (CTE) in evaluating bowel involvement in patients with ovarian cancer.

Abdom Radiol (NY) 2022 Jun 5;47(6):2023-2035. Epub 2022 Apr 5.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Purpose: To explore the utility of CTE in the evaluation of bowel invasion in patients with primary ovarian, fallopian tube, and peritoneal cancer.

Methods: This observational study included 73 patients who received CTE before operation between September 2019 and December 2021. Two radiologists reviewed CTE images, focusing on the sites and depth of bowel involvement. Read More

View Article and Full-Text PDF