4,040 results match your criteria Fallopian Tube Disorders

The impact of the female genital tract microbiome in women health and reproduction: a review.

J Assist Reprod Genet 2021 Jun 10. Epub 2021 Jun 10.

IVIRMA Valencia, Plaza de la Policía Local, 3, 46015, Valencia, Spain.

Purpose: The aim of this review is to gather the available research focusing on female genital tract (FGT) microbiome. Research question focuses in decipher which is the role of FGT microbiota in eubiosis, assisted reproduction techniques (ARTs), and gynaecological disorders, and how microbiome could be utilised to improve reproduction outcomes and to treat fertility issues.

Methods: PubMed was searched for articles in English from January 2004 to April 2021 for "genital tract microbiota and reproduction", "endometrial microbiome", "microbiome and reproduction" and "microbiota and infertility". Read More

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Prevalence of and Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study.

JCO Glob Oncol 2021 Jun;7:849-861

Medical Affairs, AstraZeneca Pharma India Ltd, Bangalore, India.

Purpose: There are deficient data on prevalence of germline mutations in breast cancer susceptibility genes 1 and 2 (/) in Indian patients with ovarian cancer who are not selected by clinical features.

Methods: This prospective, cross-sectional, noninterventional study in nine Indian centers included patients with newly diagnosed or relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer. The primary objective was to assess the prevalence of / mutations, and the secondary objective was to correlate / status with clinicopathologic characteristics. Read More

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Development of decision aids for female BRCA1 and BRCA2 mutation carriers in Germany to support preference-sensitive decision-making.

BMC Med Inform Decis Mak 2021 06 5;21(1):180. Epub 2021 Jun 5.

Institute for Health Economics and Clinical Epidemiology, The University Hospital of Cologne, Gleueler Straße 176-178, 50935, Cologne, Germany.

Background: Women with pathogenic BRCA1 and BRCA2 mutations possess a high risk of developing breast and ovarian cancer. They face difficult choices when considering preventive options. This study presents the development process of the first decision aids to support this complex decision-making process in the German healthcare system. Read More

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Tertiary cytoreduction for recurrent ovarian carcinoma: An updated and expanded analysis.

Gynecol Oncol 2021 May 25. Epub 2021 May 25.

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Obstetrics & Gynecology, Weill Cornell Medical College, New York, NY, USA. Electronic address:

Objective: We sought to describe clinicopathologic and surgical factors associated with oncologic outcomes in patients undergoing tertiary cytoreduction and to present a clinical model to identify patients with high-grade serous ovarian cancer (HGSOC) who may benefit most from tertiary cytoreduction.

Methods: We retrospectively identified patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who underwent tertiary cytoreduction at our institution from 1/1/1990-1/1/2019. Kaplan-Meier curves were used to estimate survival and compared using the log-rank test. Read More

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Successful laparoscopic resection of ovarian abscess caused by Staphylococcus aureus in a 13-year-old girl: a case report and review of literature.

BMC Womens Health 2021 05 13;21(1):198. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan.

Background: Ovarian abscesses, which occur mostly in sexually active women via recurrent salpingitis, occur rarely in virginal adolescent girls. Here, we present a case of an ovarian abscess in a virginal adolescent girl who was diagnosed and treated by laparoscopy.

Case Presentation: A 13-year-old healthy girl presented with fever lasting for a month without abdominal pain. Read More

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Fallopian Tube-Derived Tumor Cells Induce Testosterone Secretion from the Ovary, Increasing Epithelial Proliferation and Invasion.

Cancers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.

The fallopian tube epithelium is the site of origin for a majority of high grade serous ovarian carcinomas (HGSOC). The chemical communication between the fallopian tube and the ovary in the development of HGSOC from the fallopian tube is of interest since the fimbriated ends in proximity of the ovary harbor serous tubal intraepithelial carcinoma (STICs). Epidemiological data indicates that androgens play a role in ovarian carcinogenesis; however, the oncogenic impact of androgen exposure on the fallopian tube, or tubal neoplastic precursor lesions, has yet to be explored. Read More

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Hysterosalpingography in the assessment of proximal tubal pathology: a review of congenital and acquired abnormalities.

Br J Radiol 2021 Jun 29;94(1122):20201386. Epub 2021 Apr 29.

Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research (ACECR), Tehran, Iran.

Tubal and peritoneal disease are the main causes of infertility. Tubal pathology can be either congenital malformation or acquired, proximal or distal, unilateral or bilateral and transient or permanent. Several imaging methods such as laparoscopy, fluoroscopy, saline infusion sonography, and hysterosalpingography (HSG) have been used in the assessment of tubal and peritoneal pathology. Read More

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Selinexor in combination with topotecan in patients with advanced or metastatic solid tumors: Results of an open-label, single-center, multi-arm phase Ib study.

Invest New Drugs 2021 Apr 28. Epub 2021 Apr 28.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Background Selinexor, a first-in-class, oral selective inhibitor of nuclear export (SINE) compound inhibits Exportin-1(XPO1), had demonstrated synergistic activity with many chemotherapies and conferred in vivo antitumor efficacy in hematologic as well as solid tumors. Methods This open-label, single-center, multi-arm phase 1b study used a standard 3 + 3 design and a "basket type" expansion. Selinexor with intravenous topotecan was given in one of the 13 parallel arms. Read More

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An axonemal alteration in apical endometria of human adenomyosis.

Hum Reprod 2021 05;36(6):1574-1589

Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Study Question: Is there any change in the distribution of microvilli and microtubules in the apical endometria of women with adenomyosis?

Summary Answer: We observed microvilli damage in the apical endometria and an axonemal alteration characterized by abnormal distribution of longitudinal bundles of microtubules within microvilli in women with adenomyosis.

What Is Known Already: Human adenomyosis has a negative impact on female fertility. Abnormal utero-tubal sperm transport, tissue inflammation and toxic effect of chemical mediators have been proposed as contributing factors. Read More

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Contemporary Rates of Gynecologic Organ Involvement in Females with Muscle Invasive Bladder Cancer: A Retrospective Review of Women Undergoing Radical Cystectomy following Neoadjuvant Chemotherapy.

J Urol 2021 Apr 19:101097JU0000000000001784. Epub 2021 Apr 19.

Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: According to the American Urological Association/American Society of Clinical Oncology/American Society for Radiation Oncology/Society of Urologic Oncology Guideline on treatment of nonmetastatic muscle invasive bladder cancer (MIBC), females requiring radical cystectomy (RC) should undergo concomitant anterior pelvic exenteration despite low rates of malignant involvement of gynecologic organs. We present the clinicopathological characteristics of patients with MIBC treated with neoadjuvant chemotherapy (NAC) and evaluate the impact of NAC on gynecologic organ involvement.

Materials And Methods: An institutional review board approved review of patients with cT2-T3 MIBC treated with RC at our institution between 2005 and 2018 was performed. Read More

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Patient-centred outcomes and effect of disease progression on health status in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation receiving maintenance olaparib or placebo (SOLO1): a randomised, phase 3 trial.

Lancet Oncol 2021 05 13;22(5):632-642. Epub 2021 Apr 13.

Women and Infants Hospital, Providence, RI, USA.

Background: In the phase 3 SOLO1 trial, maintenance olaparib provided a significant progression-free survival benefit versus placebo in patients with newly diagnosed, advanced ovarian cancer and a BRCA mutation in response after platinum-based chemotherapy. We analysed health-related quality of life (HRQOL) and patient-centred outcomes in SOLO1, and the effect of radiological disease progression on health status.

Methods: SOLO1 is a randomised, double-blind, international trial done in 118 centres and 15 countries. Read More

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Stage of ovarian cancer at diagnosis. Does presentation as an emergency make a difference?

Eur J Obstet Gynecol Reprod Biol 2021 Jun 5;261:7-11. Epub 2021 Apr 5.

Study Conducted in Sheffield Teaching Hospitals Obstetrics and Gynaecology Unit, Sheffield, South Yorkshire, United Kingdom.

Objectives: The purpose of this study is to evaluate whether presentation of ovarian cancer as an emergency compared to presentation via referral to diagnostic clinic has an impact on stage of disease at diagnosis. Secondary outcomes include the relationship between stage of diagnosis and age as well as socioeconomic status and type of presentation (emergency or clinic referral).

Study Design: Data were obtained from the central database for all new diagnoses of ovarian, fallopian tube or primary peritoneal malignancy at a tertiary teaching hospital for 2016-2018 (n = 147). Read More

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Ovotesticular Disorder of Sexual Development and Non-Palpable Testis.

Acta Medica (Hradec Kralove) 2021 ;64(1):42-45

Fingerland Department of Pathology, University Hospital Hradec Králové, Faculty of Medicine Hradec Králové, Charles University, Czech Republic.

Disorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual's genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. Read More

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January 2021

Advancements in microfluidic systems for the study of female reproductive biology.

Endocrinology 2021 Apr 14. Epub 2021 Apr 14.

Department of Pharmaceutical Sciences, University of Illinois at Chicago.

The female reproductive tract is a highly complex physiological system, which consists of ovaries, fallopian tubes, uterus, cervix, and vagina. An enhanced understanding of the molecular, cellular, and genetic mechanisms of the tract will allow for the development of more effective assisted reproductive technologies, therapeutics, and screening strategies for female specific disorders. Traditional two-dimensional and three-dimensional static culture systems may not always reflect the cellular and physical contexts or physicochemical microenvironment necessary to understand the dynamic exchange that is crucial for the functioning of the reproductive system. Read More

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The Potential Relationship Between Different Human Female Reproductive Disorders and Sperm Quality in Female Genital Tract.

Reprod Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Spermatozoa should travel throughout the female reproductive tract to reach its ultimate goal, fertilization of the oocyte. At the ejaculation moment, millions of sperm within a few milliliters of the ejaculate are deposited at the cranial segment of vagina and make their journey to the fertilization site. This is done by means of various factors, such as sperm motility, the uterine and fallopian tubes contractility, and the ciliary movement of the lining cells. Read More

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Robotic Excision of the Vagina in a 46 XX DSD Male Patient. First Pediatric Report.

Urol J 2021 04 11:6470. Epub 2021 Apr 11.

Department of Pediatric Surgery, Pediatric Urology and Urodynamics Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.

The Disorders of Sex Differentiation (DSD) represent a wide range of congenital anomalies of the genitalia. Surgical treatment of these cases may become a challenge. We present a case of a 16-year-old boy with 46 XX DSD, SRY negative, presented with persistent dribbling incontinence, recurrent UTI and perineal pain. Read More

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Factors determining ultra-short-term survival and the commencement of active treatment in high-grade serous ovarian cancer: a case comparison study.

BMC Cancer 2021 Apr 8;21(1):378. Epub 2021 Apr 8.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, St Mary's Hospital, Research Floor, Oxford Road, Manchester, M13 9WL, UK.

Background: Despite improvements in median survival some patients with advanced ovarian cancer die within 100 days of diagnosis; the reasons for which remain poorly understood. Here we investigate if ultra short-term survival can be explained by patient characteristics or treatment pathways.

Methods: A nested case comparison study was used to examine differences between patients with high grade serous ovarian/fallopian tube cancer who died within 100 days (n = 28) compared to a comparison group of patients matched for histology and including any survival greater than 100 days (n = 134). Read More

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Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2.

Cell Death Dis 2021 Apr 7;12(4):375. Epub 2021 Apr 7.

Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, 60607, USA.

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the peritoneum; therefore, it is crucial to study disease initiation and progression using FTE-derived models. We previously demonstrated that loss of PTEN from the FTE leads to ovarian cancer. Read More

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Rationale and study design of the CHIPPI-1808 trial: a phase III randomized clinical trial evaluating hyperthermic intraperitoneal chemotherapy (HIPEC) for stage III ovarian cancer patients treated with primary or interval cytoreductive surgery.

ESMO Open 2021 04 2;6(2):100098. Epub 2021 Apr 2.

Gynecologic Oncology Department, Oscar Lambret Cancer Centre, Lille, France.

Background: Ovarian cancer remains the most lethal gynecologic malignancy with high recurrence rates. Because recurrence involves primarily the peritoneum, intraperitoneal chemotherapy is being evaluated as a new approach to treat microscopic peritoneal disease. One trial showed that cisplatin-paclitaxel intraperitoneal chemotherapy with intravenous paclitaxel improved survival but increased morbidity. Read More

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[Endometriosis of the ureter from the standpoint of implantation theory: some aspects of pathogenesis and clinical picture].

Urologiia 2021 Mar(1):126-130

Smolensk State Medical University.

The article describes such fundamental and applied aspects of pathogenesis and clinical manifestations of such rare disease as endometriosis of ureters. Frequent involvement of left ureter in its pelvic part, close to distal colon, associated with its inflammatory diseases followed by leaky gut syndrome with bacterial spread to the fallopian tube causing its inflammation and dysfunction, provoking menstrual reflux and predisposing to affection of left ovary, peritoneum and contact spread of endometriosis to ureteral wall. This mechanism fits to the regurgitation theory of endometriosis. Read More

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Insights into molecular pathways of endometriosis and endometriosis-related ovarian carcinoma.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):739-749

Department of Morphofunctional Sciences I - Histology, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;

Background: Endometriosis is a benign estrogen-dependent gynecological disease involving components of the female genital tract (uterus, Fallopian tubes, ovaries, large, round, and utero-sacral ligaments) and intra- and extraperitoneal regions. Since the moment of its etiopathogeny has been identified, the intrinsic capacity of endometriosis malignant transformation has been hypothesized.

Patients, Materials And Methods: Our study included a total number of 50 patients diagnosed with endometriosis (31 cases) and endometriosis-related ovarian carcinoma (EOC) (19 cases). Read More

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Small Non-Coding-RNA in Gynecological Malignancies.

Cancers (Basel) 2021 Mar 3;13(5). Epub 2021 Mar 3.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Gynecologic malignancies, which include cancers of the cervix, ovary, uterus, vulva, vagina, and fallopian tube, are among the leading causes of female mortality worldwide, with the most prevalent being endometrial, ovarian, and cervical cancer. Gynecologic malignancies are complex, heterogeneous diseases, and despite extensive research efforts, the molecular mechanisms underlying their development and pathology remain largely unclear. Currently, mechanistic and therapeutic research in cancer is largely focused on protein targets that are encoded by about 1% of the human genome. Read More

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Identification of two gene variants in two unrelated patients with persistent Müllerian duct syndrome: one novel variant.

Gynecol Endocrinol 2021 May 31;37(5):476-479. Epub 2021 Mar 31.

Division of Pediatric Endocrinology, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey.

Introduction: Persistent müllerian duct syndrome (PMDS) is a rare form of 46, XY disorder of sex development characterized by the persistence of the müllerian structures (uterus, fallopian tubes, the upper part of the vagina) in phenotypically and genotypically normal males. This disease occurs as a result of impairment in the synthesis, release or effect of anti-Müllerian hormone (AMH) during the embryonic period. Approximately 85-88% of PMDS cases have been reported to have or mutation. Read More

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Cellular models of development of ovarian high-grade serous carcinoma: A review of cell of origin and mechanisms of carcinogenesis.

Cell Prolif 2021 May 25;54(5):e13029. Epub 2021 Mar 25.

Center for Prevention and Therapy of Gynecological Cancers, Department of Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC.

High-grade serous carcinoma (HGSC) is the most common and malignant histological type of epithelial ovarian cancer, the origin of which remains controversial. Currently, the secretory epithelial cells of the fallopian tube are regarded as the main origin and the ovarian surface epithelial cells as a minor origin. In tubal epithelium, these cells acquire TP53 mutations and expand to a morphologically normal 'p53 signature' lesion, transform to serous tubal intraepithelial carcinoma and metastasize to the ovaries and peritoneum where they develop into HGSC. Read More

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Does the "Devil" originate from the fallopian tubes?

Semin Cancer Biol 2021 Mar 22. Epub 2021 Mar 22.

Department of Medical Oncology, Mohammed VI University Hospital, Oujda, Morocco; Faculty of Medicine and Pharmacy, Mohammed I(st) University, Oujda, Morocco.

Epithelial ovarian cancer (OC) is a heterogeneous disease and continues to be mostly diagnosed in advanced stages. The high lethality, the high rate of platinum-resistance, and the poor survival outcomes are the principal factors for categorizing OC among the most aggressive gynecological cancers. Only recently, a substantial progress has been made in our latest understanding of the origins of OC, particularly of high-grade serous histology. Read More

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Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct.

Front Cell Dev Biol 2021 8;9:605301. Epub 2021 Mar 8.

MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. They connect the ovary with the uterus and are essential for fertility. They provide the appropriate environment for gamete maintenance, fertilization and preimplantation embryonic development. Read More

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Progesterone Receptors Promote Quiescence & Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models.

J Clin Endocrinol Metab 2021 Mar 23. Epub 2021 Mar 23.

University of Minnesota, Masonic Cancer Center, Minneapolis, MN.

Content: The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial. Progesterone is considered to be protective; recent studies indicate no effect or enhanced OC risk. Knowledge of progesterone receptor (PR) signaling during altered physiology that typifies OC development is limited. Read More

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The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.

Int J Mol Sci 2021 Feb 22;22(4). Epub 2021 Feb 22.

Department of Gynaecological Endocrinology, Medical University of Warsaw, 02-091 Warsaw, Poland.

Sexually transmitted infections (STIs) caused by , and are a common cause of pelvic inflammatory disease (PID) which can lead to tubal factor infertility (TFI). TFI is one of the most common causes of infertility, accounting for 30% of female fertility problems. STIs can also have an impact on pregnancy, leading to adverse pregnancy outcomes. Read More

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February 2021