12,677 results match your criteria Factor VII


Bleeding characteristics and management of minor surgeries in rare bleeding disorders: report from a Turkish Pediatric Hematology Center.

Turk J Pediatr 2020 ;62(4):584-593

Division of Pediatric Hematology, Department of Pediatric, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Background And Objectives: In this retrospective report the aim was to present the experience about bleeding characteristics and management of minor surgeries in rare bleeding disorders (RBDs).

Methods: Twenty-six patients were included; with Factor (F) V, FV+VIII, VII, FXI deficiency and afibrinogenemia. Six of the patients were asymptomatic. Read More

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http://dx.doi.org/10.24953/turkjped.2020.04.008DOI Listing
January 2020

Postulated Adjuvant Therapeutic Strategies for COVID-19.

J Pers Med 2020 Aug 5;10(3). Epub 2020 Aug 5.

Fagron. Lichtenauerlaan 182, 3062 Rotterdam, The Netherlands.

The number of COVID-19 patients is still growing exponentially worldwide due to the high transmissibility of the SARS-CoV-2 virus. Therapeutic agents currently under investigation are antiviral drugs, vaccines, and other adjuvants that could relieve symptoms or improve the healing process. In this review, twelve therapeutic agents that could play a role in prophylaxis or improvement of the COVID-19-associated symptoms (as add-on substances) are discussed. Read More

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http://dx.doi.org/10.3390/jpm10030080DOI Listing

In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID-19 patients on anticoagulation.

J Thromb Haemost 2020 Aug 6. Epub 2020 Aug 6.

Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: COVID-19 is associated with a substantial risk of venous thrombotic events, even in the presence of adequate thromboprophylactic therapy.

Objectives: We aimed to better characterize the hypercoagulable state of COVID-19 patients in patients receiving anticoagulant therapy.

Methods: We took plasma samples of 23 patients with COVID-19 who were on prophylactic or intensified anticoagulant therapy. Read More

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http://dx.doi.org/10.1111/jth.15043DOI Listing

Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study.

J Cardiovasc Med (Hagerstown) 2020 Jul 17. Epub 2020 Jul 17.

Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza, Hospital, University of Turin, Turin, Italy.

Background: The clinical impact of stent strut thickness in coronary bifurcation lesions in small vessels has not been assessed in a real-world population.

Methods And Results: All 506 patients enrolled in the RAIN study, undergoing PCI in a vessel with a diameter 2.5 mm or less were retrospectively evaluated and divided into two groups according to stent strut thickness: 74 μm (n = 206) versus 81 μm (n = 300); 87. Read More

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http://dx.doi.org/10.2459/JCM.0000000000001037DOI Listing
July 2020
1.407 Impact Factor

Separate Effect of Perioperative Recombinant Human Factor VIIa Administration and Packed Red Blood Cell Transfusions on Midterm Survival in Lung Transplantation Recipients.

J Cardiothorac Vasc Anesth 2020 Jun 3. Epub 2020 Jun 3.

Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.

Objective: The purpose of this study was to determine the relationship between blood product transfusion, with or without recombinant human activated factor VIIa, and survival after lung transplantation.

Design: Retrospective analysis of a single center with follow-up out to 6 years post-transplantation.

Setting: Single-center academic lung transplantation program. Read More

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http://dx.doi.org/10.1053/j.jvca.2020.05.038DOI Listing

Bridging the Missing Link with Emicizumab: A Bispecific Antibody for Treatment of Hemophilia A.

Thromb Haemost 2020 Jul 27. Epub 2020 Jul 27.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Hemophilia A, characterized by absent or ineffective coagulation factor VIII (FVIII), is a serious bleeding disorder that entails severe and potentially life-threatening bleeding events. Current standard therapy still involves replacement of FVIII, but is often complicated by the occurrence of neutralizing alloantibodies (inhibitors). Management of patients with inhibitors is challenging and necessitates immune tolerance induction for inhibitor eradication and the use of bypassing agents (activated prothrombin complex concentrates or recombinant activated factor VII), which are expensive and not always effective. Read More

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http://dx.doi.org/10.1055/s-0040-1714279DOI Listing

Prophylaxis Using a Mixture of Plasma-Derived Activated Factor VII and Factor X (pdFVIIa/FX) in a Patient with Hemophilia B Complicated by Inhibitors and Allergy to Factor IX Concentrates: A Case Report.

Acta Haematol 2020 Jul 22:1-4. Epub 2020 Jul 22.

Department of Hematology and Oncology, Nagano Children's Hospital, Azumino, Japan,

Treating patients with hemophilia and inhibitors is often problematic. The presence of inhibitors negatively impacts the effectiveness of treatment to achieve hemostasis especially in patients with hemophilia B, owing mainly to allergic reactions to factor IX (FIX) concentrates and the low success rate of immune tolerance therapy. A 9-month-old boy had intracranial hemorrhage and was diagnosed with hemophilia B. Read More

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http://dx.doi.org/10.1159/000508722DOI Listing

Prolonged (post-thaw) shelf life of -80°C frozen AB apheresis plasma.

Transfusion 2020 Jul 21. Epub 2020 Jul 21.

Department of Surgery, Alrijne Medical Center, Leiderdorp, The Netherlands.

Background: Early plasma transfusion is important in the treatment of patients with major hemorrhage. Prolonged shelf life of AB type frozen -80°C and cold-stored (4°C) deep frozen plasma (DFP) will improve strategic stock management, minimize need for resupply, and make pre-hospital implementation more feasible.

Methods And Materials: Plasma products type AB of different age and origin (-30°C Fresh Frozen [(FFP], -80°C DFP [short (±1 year) and long (±7 year)] stored) were thawed (Day 0), stored at 4°C, and sampled on Days 7 and 14. Read More

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http://dx.doi.org/10.1111/trf.15963DOI Listing

Clinical problems and surgical interventions in inherited factor VII deficiency.

Turk Pediatri Ars 2020 19;55(2):184-190. Epub 2020 Jun 19.

Division of Pediatric Hematology and Oncology, İstanbul University Oncology Institute, İstanbul Turkey.

Aim: Factor VII deficiency is one of the hereditary coagulation disorders that has autosomal reccessive inheritance and is observed relatively frequently (1/500 000). It is clinically heterogeneous, and may be asymptomatic or lead to life-threatening bleeding. Thus, there is no correlation between FVII activity and clinical findings. Read More

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http://dx.doi.org/10.14744/TurkPediatriArs.2020.79069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344127PMC

Association Between R353Q (rs6046) Polymorphism in Factor VII with Coronary Heart Disease.

Int Heart J 2020 Jul 18;61(4):641-650. Epub 2020 Jul 18.

Department of Cardiology, The First Affiliated Hospital of Soochow University.

A number of studies have showed the relationship between R353Q (rs6046) polymorphism in factor VII gene and coronary heart disease (CHD). However, the results remain controversial due to the limitations of the research objects and small sample size of individual study. We conducted this meta-analysis to validate the association between R353Q (rs6046) polymorphism and the risk of CHD. Read More

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http://dx.doi.org/10.1536/ihj.19-219DOI Listing

Clinical impact of follicular oncocytic (Hürthle cell) carcinoma in comparison with corresponding classical follicular thyroid carcinoma.

Eur J Nucl Med Mol Imaging 2020 Jul 18. Epub 2020 Jul 18.

Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: There are controversial debates if patients with Hürthle cell carcinoma, also known as oxyphilic or oncocytic cell follicular thyroid carcinoma, have a poorer outcome. In this study, we systematically evaluated the clinical outcome in a large patient cohort following thyroidectomy and initial I-131 radioactive iodine therapy (RIT).

Methods: We retrospectively evaluated a total of 378 patients with diagnosed oncocytic follicular Hürthle cell carcinoma (OFTC) (N = 126) or with classical follicular thyroid carcinoma (FTC) (N = 252). Read More

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http://dx.doi.org/10.1007/s00259-020-04952-2DOI Listing

A European consensus statement on the use of four-factor prothrombin complex concentrate for cardiac and non-cardiac surgical patients.

Anaesthesia 2020 Jul 17. Epub 2020 Jul 17.

Department of Cardiothoracic Anaesthesiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.

Modern four-factor prothrombin complex concentrate was designed originally for rapid targeted replacement of the coagulation factors II, VII, IX and X. Dosing strategies for the approved indication of vitamin K antagonist-related bleeding vary greatly. They include INR and bodyweight-related protocols as well as fixed dose regimens. Read More

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http://dx.doi.org/10.1111/anae.15181DOI Listing
July 2020
3.382 Impact Factor

Survival time and prognostic factors after whole-brain radiotherapy of brain metastases from of breast cancer.

Acta Radiol Open 2020 Jul 6;9(7):2058460120938744. Epub 2020 Jul 6.

Department of Surgery, Division of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.

Background: Breast cancer has a poor prognosis due to the high risk of distant metastasis.

Purpose: To identify the prognosticators of brain metastasis from breast cancer treated by whole-brain radiotherapy.

Material And Methods: We evaluated patients diagnosed with primary brain metastasis without carcinomatous meningitis from breast cancer and had undergone whole-brain radiotherapy as initial treatment between 1 January 2010 and 30 September 2019. Read More

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http://dx.doi.org/10.1177/2058460120938744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338738PMC

Beyond thrombosis: the impact of tissue factor signaling in cancer.

J Hematol Oncol 2020 Jul 14;13(1):93. Epub 2020 Jul 14.

Department of Neurological Surgery, Northwestern University, 303 East Superior St, Chicago, IL, 60611, USA.

Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also activate receptor tyrosine kinases (RTKs) and integrins. Read More

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http://dx.doi.org/10.1186/s13045-020-00932-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362520PMC

Enhanced protection against lipopolysaccharide-induced acute lung injury by autologous transplantation of adipose-derived stromal cells combined with low tidal volume ventilation in rats.

J Cell Physiol 2020 Jul 13. Epub 2020 Jul 13.

Department of ENT, The First Hospital Affiliated at China Medical University, Shenyang, China.

Adipose-derived stromal cells (ADSCs) showed excellent capacity in regeneration and tissue protection. Low tidal volume ventilation (LVT) strategy demonstrates a therapeutic benefit on the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). This study, therefore, aimed to undertaken determine whether the combined LVT and ADSCs treatment exerts additional protection against lipopolysaccharide (LPS)-induced ALI in rats. Read More

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http://dx.doi.org/10.1002/jcp.29936DOI Listing

Amelioration of copper toxicity to a tropical freshwater microalga: Effect of natural DOM source and season.

Environ Pollut 2020 Jul 6;266(Pt 2):115141. Epub 2020 Jul 6.

Faculty of Science, University of Technology Sydney Broadway, NSW 2007 Australia; La Trobe University, School of Life Science, Department of Ecology, Environment and Evolution, Freshwater Research Centre, Albury/Wodonga Campus, VIC 3690, Australia. Electronic address:

Australian tropical freshwaters can experience extreme seasonal variability in rainfall and run off, particularly due to pulse events such as storms and cyclones. This study investigated how seasonal variability in dissolved organic matter (DOM) quality impacted the chronic toxicity of copper to a tropical green alga (Chlorella sp.) in the presence of two concentrations of DOM (low: ∼2 mg C/L; high: ∼10 mg C/L) collected from three tropical waters. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115141DOI Listing

The rs1051931 G>A Polymorphism in the Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population.

Front Pediatr 2020 23;8:338. Epub 2020 Jun 23.

Department of Blood Transfusion and Clinical Lab, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.

Kawasaki disease (KD) is a common cardiovascular disease in infants and young children, with fever, rash, and conjunctivitis as the main clinical manifestations, which can lead to the occurrence of coronary aneurysms. Intravenous immunoglobulin (IVIG) is the preferred treatment for KD patients, but 10-20% of patients are resistant to IVIG. Lipoprotein-associated phospholipase A 2 (Lp-PLA2) is a potential therapeutic target for coronary atherosclerotic heart disease, and the polymorphism of Phospholipase A2 Group VII () is closely related to the activity of Lp-PLA2, of which rs1051931 is the strongest. Read More

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http://dx.doi.org/10.3389/fped.2020.00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324548PMC

IgG Fc N-glycosylation translates MHCII haplotype into autoimmune skin disease.

J Invest Dermatol 2020 Jul 9. Epub 2020 Jul 9.

Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany. Electronic address:

The major histocompatibility complex (MHC)-haplotype represents the most prevalent genetic risk factor for the development of autoimmune diseases. However, the mechanisms by which MHC-associated genetic susceptibility translates into autoimmune disease are not fully understood. Epidermolysis bullosa acquisita (EBA) is an autoimmune skin blistering disease driven by autoantibodies to type VII collagen (COL7). Read More

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http://dx.doi.org/10.1016/j.jid.2020.06.022DOI Listing

How Much Is the Inevitable Loss of Different Coagulation Factors During Blood Product-Free Liver Transplantations?

Transplant Proc 2020 Jul 8. Epub 2020 Jul 8.

Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.

Background: Bloodless liver transplantations (LT) have already been reported, but special characteristics of hemostatic changes remain less defined. The aim of this study was to evaluate the "inevitable" loss of coagulation factors (CF) in blood product-free LT.

Methods: Blood product and CF concentrate-free LT patient data were analyzed in terms of the first 2 days of perioperative hemostasis kinetics (N = 59). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.006DOI Listing

Profile of natural anticoagulant, coagulant factor and anti-phospholipid antibody in critically ill COVID-19 patients.

J Thromb Thrombolysis 2020 Jul 9. Epub 2020 Jul 9.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 1# Shuai Fu Yuan, Beijing, 100730, China.

The outbreak of novel coronavirus disease 2019 (COVID-19) has now become a global pandemic. Coagulopathy has been reported widely in critically ill COVID-19 patients and was related to high mortality. However, the comprehensive coagulation profiles have not been examined and the underlying mechanism of the coagulopathy in COVID-19 patients is unclear. Read More

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http://dx.doi.org/10.1007/s11239-020-02182-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346854PMC

The traceability of commercial plasma calibrators to the plasma International Standards for factor VIII and factor IX.

Int J Lab Hematol 2020 Jul 8. Epub 2020 Jul 8.

Haemostasis Section, Biotherapeutics Group, National Institute for Biological Standards and Control (NIBSC), Potters Bar, Hertfordshire, United Kingdom.

Accurate measurement of coagulation factors is essential, especially for diagnosis of deficiency. Clinical laboratories use commercially available plasma calibrators, which should be traceable to the relevant plasma International Standard (IS). This study assessed the relationship between the plasma IS for factors IX (FIX) and VIII (FVIII) and some commonly used commercial calibrators. Read More

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http://dx.doi.org/10.1111/ijlh.13277DOI Listing

Management of pregnancy in women with factor VII deficiency: A case series.

Haemophilia 2020 Jul 26;26(4):652-656. Epub 2020 Jun 26.

Division of Hematology-Oncology, Department of Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA.

Introduction: Inherited factor VII deficiency is the most common autosomal recessive inherited bleeding disorder, with an estimated incidence of one per 500 000 cases in the general population. Bleeding manifestations correlate poorly with circulating FVII levels. During pregnancy, increases in FVII levels can occur in women with mild-moderate FVII deficiencies but not in those with severe deficiency. Read More

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http://dx.doi.org/10.1111/hae.14086DOI Listing

Epidemic Trend of COVID-19 Transmission in India During Lockdown-1 Phase.

J Community Health 2020 Jun 23. Epub 2020 Jun 23.

Center for Water Sciences, Chitkara University Institute of Engineering and Technology, Chitkara University, Punjab, 140401, Rajpura, India.

To assess the current epidemic trend of COVID-19/SARS-CoV-2 in India, the epidemic dynamics of COVID-19 cases in India in terms of Case Fatality Rate (CFR), Case Recovery Rate (CRR) and Mortality rate (MR) COVID-19 have been evaluated during Lockdown-1. The analysis includes (i) epidemic curve of Covid-19 cases (ii) demographic analysis (iii) calculation of the CFR and CRR by different methods (iv) calculation of MR (v) Geo-temporal analysis (vi) epidemiological transmission factor (vii) evaluation of the effects and impact of infection, prevention and control in India. A total of 10,815 COVID-19 confirmed cases have been reported in 31 states/union territories as of April 14, 2020 with 9272 active cases (85. Read More

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http://dx.doi.org/10.1007/s10900-020-00863-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309423PMC

Effects of platelet and phospholipids on clot formation activated by a small amount of tissue factor.

Thromb Res 2020 Jun 10;193:146-153. Epub 2020 Jun 10.

Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of medicine, Tsu, Japan.

Introduction: Physiological coagulation is considered to activate coagulation factor IX (FIX) by a small amount of tissue factor (TF) and activated coagulation factor VII (FVIIa) with the presence of platelets. A Clot waveform analysis (CWA) may be useful for evaluating physiological coagulation.

Material And Methods: A CWA using a small amount of TF (CWA/sTF) was performed in platelet-rich plasma (PRP), platelet-poor plasma (PPP), several phospholipids (PLs) and patients with lupus anticoagulant (LA), idiopathic thrombocytopenic purpura (ITP) or inhibitor for FVIII. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.06.018DOI Listing

Interrogation of the cell wall integrity pathway in identifies a putative negative regulator of transcription involved in chitin deposition.

Gene X 2020 Dec 28;5:100028. Epub 2020 Jan 28.

Leiden University, Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Sylviusweg 72, 2333 BE Leiden, the Netherlands.

Post-fermentation fungal biomass waste provides a viable source for chitin. Cell wall chitin of filamentous fungi, and in particular its de-acetylated derivative chitosan, has a wide range of commercial applications. Although the cell wall of filamentous fungi comprises 10-30% chitin, these yields are too low for cost-effective production. Read More

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http://dx.doi.org/10.1016/j.gene.2020.100028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285910PMC
December 2020

Risk factors of diffuse alveolar hemorrhage after acute ischemic stroke treated with tissue-type plasminogen activator. The effectiveness of activated recombinant factor VII treatment.

Surg Neurol Int 2020 30;11:129. Epub 2020 May 30.

Department of Neurosurgery, Kanazawa Medical Center, Shimoishibikimachi, Kanazawa, Ishikawa, Japan.

Background: Diffuse alveolar hemorrhage (DAH) is a rare and frequently life-threatening complication of a variety of conditions. DAH may result from coagulation disorders, inhaled toxins, or infections. We report a series of patients who developed DAH after receiving a tissue-type plasminogen activator (tPA) for acute cerebral infarction. Read More

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http://dx.doi.org/10.25259/SNI_2_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294161PMC

Massive Transfusion Protocols for Pediatric Patients: Current Perspectives.

J Blood Med 2020 21;11:163-172. Epub 2020 May 21.

Pediatric Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.

In adults, the use of balanced resuscitation and study of massive transfusion protocols have led to improved outcomes for patients and continues to be refined. In children, massive transfusion protocols require further development and study to assess efficacy. Standardization is needed as transfusions and activation of protocols still rely on physician discretion in most pediatric settings. Read More

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http://dx.doi.org/10.2147/JBM.S205132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247594PMC

Concomitant Use of rFVIIa and Emicizumab in People with Hemophilia A with Inhibitors: Current Perspectives and Emerging Clinical Evidence.

Ther Clin Risk Manag 2020 22;16:461-469. Epub 2020 May 22.

Department of Oncology, Center for Bleeding Disorders and Coagulation, Careggi University Hospital, Florence, Italy.

Emicizumab, a humanized, bi-specific, monoclonal antibody subcutaneously administered, mimicking the function of FVIIIa, represents a milestone in treatment of patients affected by hemophilia A complicated with inhibitors. The HAVEN 1 and 2 studies have clearly established its superiority compared to bypassing agents for routine prophylaxis in preventing or reducing bleeding episodes in adult and pediatric patients with inhibitors. However, its protection against bleeding is only partial, and concomitant use of a bypassing agent may be required with potential prothrombotic risk. Read More

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http://dx.doi.org/10.2147/TCRM.S205310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251291PMC

Thrombotic complications of COVID-19 may reflect an upregulation of endothelial tissue factor expression that is contingent on activation of endosomal NADPH oxidase.

Open Heart 2020 06;7(1)

Catalytic Longevity, Encinitas, California, USA.

The high rate of thrombotic complications associated with COVID-19 seems likely to reflect viral infection of vascular endothelial cells, which express the ACE2 protein that enables SARS-CoV-2 to invade cells. Various proinflammatory stimuli can promote thrombosis by inducing luminal endothelial expression of tissue factor (TF), which interacts with circulating coagulation factor VII to trigger extrinsic coagulation. The signalling mechanism whereby these stimuli evoke TF expression entails activation of NADPH oxidase, upstream from activation of the NF-kappaB transcription factor that drives the induced transcription of the TF gene. Read More

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http://dx.doi.org/10.1136/openhrt-2020-001337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298678PMC

"Noninfective Endocarditis": A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male.

Diagnostics (Basel) 2020 Jun 8;10(6). Epub 2020 Jun 8.

Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland.

We report a case of a young male who presented with acute limb ischemia after sport. With no prior history of disease, a non-infective endocarditis of the native aortic valve was diagnosed. After surgical valve replacement, the patient suffered from acute myocardial ischemia under phenprocoumon therapy. Read More

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http://dx.doi.org/10.3390/diagnostics10060384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345217PMC

Factor VII Deficiency in Patients Receiving Chronic Packed Cell Transfusions.

J Pediatr Hematol Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatric Hematology Oncology, Saban Pediatric Medical Center, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.

Acquired factor VII deficiency is a rare coagulopathy that has not been reported in transfusion-dependent patients so far. In this study, we reviewed files of 26 transfusion-dependent patients for coagulation profiles, factor V levels, factor VII levels, possible environmental factors influencing factor VII levels, and bleeding history. In 26 of 29 patients (89. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001854DOI Listing
June 2020
0.956 Impact Factor

[Primary culture and identification of mouse brain microvascular endothelial cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Apr;36(4):325-329

College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China. *Corresponding author, E-mail: 2422198977@ qq.com.

Objective To develop and establish a simple and repeatable method of primary culture of mouse brain microvascular endothelial cells (BMECs) of relatively high purity. Methods Isolated and cultured from the brain tissue of ICR mice aged 2-3 weeks old, the mouse BMECs were gained through physical fragmentation methods such as cutting up and passing through cell sieve, BSA density gradient centrifugation and chemical enzyme digestion. The digestion time of 1 g/L type II collagenase was strictly controlled within 15-20 minutes. Read More

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Whole-body heat exposure causes developmental stage-specific apoptosis of male germ cells.

Mol Reprod Dev 2020 Jun 7;87(6):680-691. Epub 2020 Jun 7.

Department of Biological Sciences, Seoul National University, Seoul, Korea.

Humans are occasionally exposed to extreme environmental heat for a prolonged period of time. Here, we investigated testicular responses to whole-body heat exposure by placing mice in a warm chamber. Among the examined tissues, the testis was found to be most susceptible to heat stress. Read More

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http://dx.doi.org/10.1002/mrd.23348DOI Listing
June 2020
2.527 Impact Factor

Development of an Effective and Stable Genotype-Matched Live Attenuated Newcastle Disease Virus Vaccine Based on a Novel Naturally Recombinant Malaysian Isolate Using Reverse Genetics.

Vaccines (Basel) 2020 Jun 2;8(2). Epub 2020 Jun 2.

Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor 43400, Malaysia.

Genotype VII Newcastle disease viruses are associated with huge economic losses in the global poultry industry. Despite the intensive applications of vaccines, disease outbreaks caused by those viruses continue to occur frequently even among the vaccinated poultry farms. An important factor in the suboptimal protective efficacy of the current vaccines is the genetic mismatch between the prevalent strains and the vaccine strains. Read More

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http://dx.doi.org/10.3390/vaccines8020270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349954PMC

Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa.

Mol Ther 2020 Aug 20;28(8):1833-1845. Epub 2020 May 20.

Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA. Electronic address:

Systemic skin-selective therapeutics would be a major advancement in the treatment of diseases affecting the entire skin, such as recessive dystrophic epidermolysis bullosa (RDEB), which is caused by mutations in the COL7A1 gene and manifests in transforming growth factor-β (TGF-β)-driven fibrosis and malignant transformation. Homing peptides containing a C-terminal R/KXXR/K motif (C-end rule [CendR] sequence) activate an extravasation and tissue penetration pathway for tumor-specific drug delivery. We have previously described a homing peptide CRKDKC (CRK) that contains a cryptic CendR motif and homes to angiogenic blood vessels in wounds and tumors, but it cannot penetrate cells or tissues. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403337PMC
August 2020
6.227 Impact Factor

Laparoscopic roux-en-Y gastric bypass versus sleeve gastrectomy for teenagers with severe obesity - TEEN-BEST: study protocol of a multicenter randomized controlled trial.

BMC Surg 2020 Jun 3;20(1):117. Epub 2020 Jun 3.

Obesity Center Máxima - Máxima Medical Center, Eindhoven/Veldhoven, The Netherlands.

Background: Recent data support the use of bariatric surgery in adolescents with severe obesity following unsuccessful non-surgical treatments. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have demonstrated reasonably similar weight loss and reduction of obesity related comorbidities in randomized trials in adults. SG has internationally become the most commonly used procedure in adolescents, yet long-term outcome data are lacking. Read More

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http://dx.doi.org/10.1186/s12893-020-00778-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268239PMC

Neoadjuvant Treatment in Upper Rectal Cancer Does Not Improve Oncologic Outcomes But Increases Postoperative Morbidity.

Anticancer Res 2020 Jun;40(6):3579-3587

Department of Digestive, Oncological, Endocrine, Hepato-Biliary, Pancreatic and Liver Transplant Surgery, Trousseau Hospital, Chambray Les Tours, France

Background/aim: Neoadjuvant chemoradiation/radiation therapy in locally advanced (LA) upper rectal adenocarcinoma management remains unclear. The aim of this study was to compare outcomes between neoadjuvant chemoradiation therapy (CRT) and upfront surgery (US).

Patients And Methods: A total of 127 patients were retrospectively included from 5 centers (79 treated with US and 48 with CRT). Read More

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http://dx.doi.org/10.21873/anticanres.14348DOI Listing

RasGRF1 participates in the protective effect of tanshinone IIA on depressive like behaviors of a chronic unpredictable mild stress induced mouse model.

Gene 2020 Sep 29;754:144817. Epub 2020 May 29.

Psychiatry Department I, Qingdao Mental Health Center, Qingdao University, Qingdao, Shandong 266034, China. Electronic address:

Tanshinone IIA (Tan IIA) is reported to have neuroprotective effects to suppress cell apoptosis of cortical neurons induced by Aβ through inhibiting oxidative stress. Nevertheless, few studies have investigated the effects of Tan IIA on depressive disorder. Here, we aimed to measure the effects of Tan IIA on chronic unpredictable mild stress (CUMS) induced mouse model and its underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144817DOI Listing
September 2020

[Analysis of a Chinese pedigree affected with hereditary factor VII deficiency caused by compound heterozygous variants of F7 gene].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Jun;37(6):633-636

Center of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325015, China.

Objective: To explore the molecular basis for a Chinese pedigree affected with hereditary coagulation factor VII (FVII) deficiency.

Methods: The coding regions of F7 gene were amplified by PCR and sequenced. Suspected variants were confirmed by reverse sequencing and validated in other members from the pedigree. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.06.009DOI Listing

Prophylaxis with rFVIIa before third molar extraction in a patient with factor VII deficiency.

J Biol Regul Homeost Agents 2020 Mar-Apr;34(2):679-682

Department of Head and Neck, Oral Surgery and Implantology Unit, Institute of Clinical Dentistry, Catholic University of the Sacred Heart, Gemelli University Polyclinic Foundation, Rome, Italy.

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http://dx.doi.org/10.23812/20-70-L-3DOI Listing

Coagulation in liver surgery: an observational haemostatic profile and thromboelastography study.

ANZ J Surg 2020 Jun 26;90(6):1112-1118. Epub 2020 May 26.

Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Background: International normalized ratio (INR) is used as a marker of the haemostatic status following liver resection. However, the impact of liver resection on haemostasis is complex and beyond what can be measured by INR. This study aimed to prospectively assess haemostatic profile following liver resection and determine if INR measurement can safely guide post-operative thromboprophylaxis. Read More

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http://dx.doi.org/10.1111/ans.15912DOI Listing

Antithrombotic and hemostatic stewardship: evaluation of clinical outcomes and adverse events of recombinant factor VIIa (Novoseven) utilization at a large academic medical center.

Ther Adv Cardiovasc Dis 2020 Jan-Dec;14:1753944720924255

Department of Pharmacy, NYU Langone Health, 550 First Avenue, New York, NY 10016, USA.

Background: Recombinant factor VIIa (rFVIIa) (Novoseven®) is utilized for the reversal of anticoagulation-associated bleeding and refractory bleeding in cardiac surgery. In August 2015, rFVIIa was transferred from the blood bank to the pharmacy at New York University (NYU) Langone Health. Concordantly, an off-label dosing guideline was developed. Read More

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http://dx.doi.org/10.1177/1753944720924255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249557PMC

FUT7 promotes the malignant transformation of follicular thyroid carcinoma through α1,3-fucosylation of EGF receptor.

Exp Cell Res 2020 Aug 20;393(2):112095. Epub 2020 May 20.

Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address:

Aberrant protein glycosylation is involved in many diseases including cancer. This study investigated the role of fucosyltransferase VII (FUT7) in the progression of follicular thyroid carcinoma (FTC). FUT7 expression was found to be upregulated in FTC compared to paracancerous thyroid tissue, and in FTC with T2 stage of TMN classification compared to FTC with T1 stage. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112095DOI Listing

Response to the Letter to the Editor by Eshghi P et al.

Haemophilia 2020 07 22;26(4):e220. Epub 2020 May 22.

Consultant, Medical Writer, Milano, Italy.

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http://dx.doi.org/10.1111/hae.14020DOI Listing
July 2020
2.603 Impact Factor

Evaluation of a new thromboplastin reagent STA-NeoPTimal on a STA R Max analyzer for the measurement of prothrombin time, international normalized ratio and extrinsic factor levels.

Int J Lab Hematol 2020 May 19. Epub 2020 May 19.

Department of Laboratory Medicine, Université catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), Yvoir, Belgium.

Introduction: We aimed at evaluating the performance of a new prothrombin time (PT) reagent (STA-NeoPTimal) with two other PT reagents (STA-Neoplastine R and STA-Neoplastine CI Plus) and the reference PT reagent used in our laboratory (ReadiPlasTin).

Methods: Evaluation consisted in intra- and interassay precision assessment, determination of sensitivity to unfractionated heparin (UFH) or enoxaparin in spiked samples and to direct oral anticoagulants (DOACs) in patients (n = 43). Method comparison of the 4 PT reagents, factor II, V, VII and X assays was tested on normal (n = 20) and abnormal samples: VKA (n = 47), preoperative (n = 23), liver failure (n = 12) and burned patients (n = 37). Read More

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http://dx.doi.org/10.1111/ijlh.13236DOI Listing

Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate.

Cell Mol Bioeng 2020 Jun 23;13(3):179-187. Epub 2020 Mar 23.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR USA.

Introduction: Tissue factor (TF) and factor (F) VII, components of the extrinsic pathway of blood coagulation, are essential for hemostatic plug formation in response to injury; less clear are their roles in propagating thrombosis, as observational data in humans with congenital FVII deficiency suggests persistent thrombotic and bleeding risk even at significantly decreased FVII levels. We aimed to define the contribution of FVII to thrombus formation and hemostasis using a non-human primate model.

Methods: We treated baboons with a FVII antisense oligonucleotide (ASO) and measured platelet and fibrin deposition inside and distal to collagen- or TF-coated vascular grafts. Read More

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http://dx.doi.org/10.1007/s12195-020-00613-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225220PMC

Peculiar Congenital Factor VII Defect with the Proposita and Her Mother Showing the Same Compound Heterozygosity for Thr384Met and Arg413Gln.

Acta Haematol 2020 May 12:1-5. Epub 2020 May 12.

Bioquimica Clinica, Universidad Fasta, Mar del Plata, Argentina.

Objective: To investigate a family with factor VII (FVII) deficiency from Argentina.

Patients And Methods: The proposita is a 14-year-old girl who presented with a mild to moderate bleeding tendency. Menorrhagia is controlled with periodical administration of small doses of recombinant FVII concentrate. Read More

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http://dx.doi.org/10.1159/000507071DOI Listing

International recommendations on the diagnosis and treatment of acquired hemophilia A.

Haematologica 2020 Jul 7;105(7):1791-1801. Epub 2020 May 7.

Green Templeton College, University of Oxford, Oxford, UK.

Acquired hemophilia A (AHA), a rare bleeding disorder caused by neutralizing autoantibodies against coagulation factor VIII (FVIII), occurs in both men and women without a previous history of bleeding. Patients typically present with an isolated prolonged activated partial thromboplastin time due to FVIII deficiency. Neutralizing antibodies (inhibitors) are detected using the Nijmegen-modified Bethesda assay. Read More

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http://dx.doi.org/10.3324/haematol.2019.230771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327664PMC

Non-additive effect on thrombin generation when a plasma-derived factor VIII/von Willebrand factor (FVIII/VWF) is combined with emicizumab in vitro.

J Thromb Haemost 2020 Aug 25;18(8):1934-1939. Epub 2020 Jun 25.

Bioscience Research Group, Grifols, Raleigh, NC, USA.

Background: Emicizumab is an alternative non-factor approach for treating patients with hemophilia A. However, there is a potential risk of thrombotic events when emicizumab is concomitantly administered with pro-hemostatic therapies.

Objectives: To assess the hemostatic effect in vitro when a plasma-derived factor VIII concentrate containing von Willebrand factor (pdFVIII/VWF) was added to hemophilia A plasma (HAp) in combination with emicizumab. Read More

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http://dx.doi.org/10.1111/jth.14887DOI Listing