12,303 results match your criteria Factor VII


Establishment of gene-edited pigs expressing human blood coagulation factor VII and albumin for bioartificial liver use.

J Gastroenterol Hepatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University.

Background And Aim: Bioartificial livers (BALs) are considered as a solution to bridge patients with acute liver failure to liver transplantation or to assist in spontaneous recovery for patients with end-stage liver disease. Pig is the best donor of hepatocytes for BALs in clinical trials, because metabolic and detoxification function of its liver are close to human. However, using pig hepatocytes for BALs remains controversial for safety concern owing to nonhuman proteins secretion. Read More

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http://dx.doi.org/10.1111/jgh.14666DOI Listing

Role of Cell Surface Lipids and Thiol-Disulphide Exchange Pathways in Regulating the Encryption and Decryption of Tissue Factor.

Thromb Haemost 2019 Mar 12. Epub 2019 Mar 12.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States.

Tissue factor (TF), a transmembrane glycoprotein, is the cellular receptor of the coagulation factors VII (FVII) and VIIa (FVIIa). The formation of TF-FVIIa complex triggers the initiation of the blood coagulation pathway. TF plays an essential role in haemostasis, but an aberrant expression of TF activity contributes to thrombotic disorders. Read More

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http://dx.doi.org/10.1055/s-0039-1681102DOI Listing

Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis.

Sci Rep 2019 Mar 11;9(1):4073. Epub 2019 Mar 11.

Division of Molecular Medicine, Bose Institute, P-1/12, Calcutta Improvement Trust Scheme VII M, Kolkata, 700054, India.

Vasculogenesis and angiogenesis are process of formation of blood vessels. Blood vessels are evolved to distribute nutrients and oxygen to distant organs. These vessels are crucial for growth and repair of wounded tissue. Read More

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http://www.nature.com/articles/s41598-019-40626-2
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http://dx.doi.org/10.1038/s41598-019-40626-2DOI Listing
March 2019
8 Reads

, a Novel Ethylene Response Factor VII from , Enhances Waterlogging Resistance in Transgenic Tobacco through Improving Expression Levels of and Genes.

Int J Mol Sci 2019 Mar 8;20(5). Epub 2019 Mar 8.

Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.

APETALA2/ethylene-responsive factor superfamily (AP2/ERF) is a transcription factor involved in abiotic stresses, for instance, cold, drought, and low oxygen. In this study, a novel ethylene-responsive transcription factor named was isolated from 'Jinkui'. transcription levels in other reproductive organs except for the pistil were higher than those in the vegetative organs (root, stem, and leaf) in kiwi fruit. Read More

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http://dx.doi.org/10.3390/ijms20051189DOI Listing

Thrombotic events in homozygotes with a proven or highly probable Arg304Gln Factor VII mutation (FVII Padua) 1): only limited replacement therapy is needed in case of surgery.

Cardiovasc Hematol Disord Drug Targets 2019 Mar 7. Epub 2019 Mar 7.

Dept of Medicine, University of Padua Medical School, Padua. Italy.

Objective: to investigate the prevalence of thrombotic events among patients with proven or highly probable homozygosis for the Arg304Gln (Factor VII Padua) defect or compound heterozygosis containing the Arg304Gln mutation.

Patients And Methods: Homozygotes and compound heterozygotes proven by molecular studies to have the Arg304Gln mutation were gathered from personal files and from two PubMed searches. In addition, patients with probable homozygosis on the basis of clotting tests (discrepancies among Factor VII activity levels according to the tissue thromboplastin used) were also gathered. Read More

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http://dx.doi.org/10.2174/1871529X19666190308114842DOI Listing

Establishment of an HPLC-based method to identify key proteases of proteins in vitro.

Anal Biochem 2019 Mar 5;573:1-7. Epub 2019 Mar 5.

Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Given that the biological functions of proteins may decrease or even be lost due to degradation by proteases, it is of great significance to identify potential proteases that degrade protein drugs during systemic circulation. In this work, we describe a method based on high-performance liquid chromatography (HPLC) to identify key proteases that degrade therapeutic proteins in blood, including endopeptidases and exopeptidases. Here, the degradation of proteins was detected by competition with standard substrates of proteases and is shown as the relative residue rate. Read More

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http://dx.doi.org/10.1016/j.ab.2019.02.030DOI Listing

Molecular docking and dynamic studies of crepiside E beta glucopyranoside as an inhibitor of snake venom PLA2.

J Mol Model 2019 Mar 8;25(4):88. Epub 2019 Mar 8.

Department of Computational Biology and Bioinformatics, Karyavattom, University of Kerala, Thiruvananthapuram, Kerala, 695581, India.

Alternative treatments from plant-derived small molecules for neutralizing the venom lethality in snake envenomation are prevalent now. Elephantopus scaber, a tropical plant species has been recognized for its various pharmacological activities and especially anti-snake venom property; however, the molecular basis for this property is not understood. It is reported that snake venom PLA2 is a toxic factor with pharmacological effects independent of their catalytic activity. Read More

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http://dx.doi.org/10.1007/s00894-019-3954-2DOI Listing

A Phase 2 Study of PCI-27483, a Factor VIIa Inhibitor in Combination with Gemcitabine for Advanced Pancreatic Cancer.

Oncology 2019 Mar 7;96(4):1-6. Epub 2019 Mar 7.

Gabrail Cancer Center, Canton, Ohio, USA.

Objectives: Tissue factor overexpression is associated with tumor progression, venous thromboembolism, and worsened survival in patients with cancer. Tissue factor and activated factor VII (FVIIa) complex may contribute to tumor invasiveness by promoting cell migration and angiogenesis. The study objective was to evaluate safety, pharmacokinetics, and efficacy of PCI-27483, a selective FVIIa inhibitor. Read More

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http://dx.doi.org/10.1159/000495988DOI Listing
March 2019
2 Reads

[Clinical and genotypic analysis of two Chinese pedigrees affected with hereditary coagulable factor VII deficiency].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Mar;36(3):221-224

Department of Laboratory Medicine, the Second Affiliated Hospital, Wenzhou Medical University , Wenzhou, Zhejiang 325027, China.

Objective: To explore molecular etiology and clinical characteristics of two pedigrees affected with hereditary factor VII(FVII) deficiency.

Methods: The nine exons and flanking sequences of the F7 gene of the probands were amplified by PCR. The amplicons were analyzed by direct sequencing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2019.03.007DOI Listing
March 2019
2 Reads

Prophylaxis of peripartum haemorrhage using recombinant factor VIIa (rfVIIa) in pregnant women with congenital factor VII deficiency: A case report and literature review.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 22;235:77-80. Epub 2019 Feb 22.

Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University Hospital of Cagliari, Italy.

Congenital factor VII deficiency is a rare autosomal recessive disorder associated to different haemorrhagic manifestations. Labour and delivery may cause bleeding risk in patients with this coagulation deficit, thus it is appropriate to clarify whether prophylaxis of peripartum haemorrhage is necessary. To date, there are very few cases in scientific literature which report the management of women with congenital factor VII deficiency during labour, and a consensus for prophylaxis does not exist. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.02.017DOI Listing
February 2019

In silico method for identification of novel copper and iron metabolism proteins in various neurodegenerative disorders.

Neurotoxicology 2019 Mar 1;73:50-57. Epub 2019 Mar 1.

Department of Biochemistry, AIIMS, Jodhpur, Rajasthan, India. Electronic address:

Copper (Cu) and Iron (Fe) has been the subject of intensive research over several decades as numerous seminal studies robustly support the involvement of Cu and Fe metabolism dyshomeostasis as a common denominator in several neurodegenerative disorders (particularly Alzheimer's disease and Parkinson's disease); however, till date, the exact "cause-effect" association has not been elucidated. Thus, there is urgent need to look for newer association/pathways of these redox active elements in different neuropathological conditions. Therefore, in this study, we have used bioinformatics based approach to identify novel Cu and Fe metabolism proteins in neurodegenerative disorders using Cytoscape software. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X183048
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http://dx.doi.org/10.1016/j.neuro.2019.02.020DOI Listing
March 2019
5 Reads
3.379 Impact Factor

Checkpoint inhibitor treatment induces an increase in HbA1c in nondiabetic patients.

Melanoma Res 2019 Feb 26. Epub 2019 Feb 26.

AP-HP Department of Diabetology, INSERM U1138, Lariboisiére Hospital, Université Paris Diderot - Paris VII, Sorbonne Paris Cité, Paris, France.

Immunotherapy greatly improves clinical outcomes in treated patients with cancer. However, the long-lasting immune response and long duration of therapy could induce long-term adverse effects owing to the chronic inflammation induced. Type 2 diabetes is now recognized as an inflammatory disease. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000585DOI Listing
February 2019

miR-145-5p regulates fibrotic features of recessive dystrophic epidermolysis bullosa skin fibroblasts.

Br J Dermatol 2019 Feb 28. Epub 2019 Feb 28.

Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy.

Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disorder caused by mutations in the COL7A1 gene encoding type VII collagen, a cutaneous basement membrane component essential for epidermal-dermal adhesion. Hallmarks of the disease are unremitting blistering and chronic wounds with severe inflammation and fibrosis. microRNAs are post-transcriptional regulators of gene expression also implicated in fibrotic processes. Read More

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http://dx.doi.org/10.1111/bjd.17840DOI Listing
February 2019
1 Read

Hypoxic Conditions in Crown Galls Induce Plant Anaerobic Responses That Support Tumor Proliferation.

Front Plant Sci 2019 5;10:56. Epub 2019 Feb 5.

Institute of Biology I, RWTH Aachen University, Aachen, Germany.

infection of wounded plant tissues causes the formation of crown gall tumors. Upon infection, genes encoded on the tumor inducing plasmid are integrated in the plant genome to induce the biosynthesis of auxin and cytokinin, leading to uncontrolled cell division. Additional sequences present on the bacterial T-DNA encode for opine biosynthesis genes, which induce the production of opines that act as a unique carbon and nitrogen source for . Read More

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http://dx.doi.org/10.3389/fpls.2019.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371838PMC
February 2019
1 Read

Factor VII Gene Defects: Review of Functional Studies and Their Clinical Implications

Iran Biomed J 2019 Feb 24. Epub 2019 Feb 24.

Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran.

Coagulation factors belong to a family of plasma glycosylated proteins that should be activated for appropriate blood coagulation. Congenital deficiencies of these factors cause inheritable hemorrhagic diseases. Factor VII (FVII) deficiency is a rare bleeding disorder with variable clinical symptoms. Read More

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February 2019

A Propensity-Score Matched Analysis on Outcomes Using Recombinant Activated Factor VII in Pediatric Cardiac Surgery.

J Cardiothorac Vasc Anesth 2018 Dec 12. Epub 2018 Dec 12.

Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Skate Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objective: To evaluate the effect of recombinant activated factor VII (rFVIIa) administration on outcomes in pediatric cardiac surgery patients with postoperative bleeding.

Design: A propensity score-matched retrospective study.

Setting: Single tertiary medical center. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.12.016DOI Listing
December 2018
1 Read

HEK293 Cells Overexpressing Nuclear Factor E2-Related Factor-2 Improve Expression of Recombinant Coagulation Factor VII.

Mol Biotechnol 2019 Feb 21. Epub 2019 Feb 21.

Stem cell and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran.

The mammalian expression system plays a key central role in the production of therapeutic recombinant proteins. Conspicuously, any improvements in the expression system which lead to a higher expression level would have an impact especially in bio-pharmaceutical industries. In the current study, to take steps toward the improvement of expression of recombinant protein, first, we established a stable HEK293 cell line to overexpress a well-known cytoprotective and antioxidant gene, Nrf2. Read More

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http://dx.doi.org/10.1007/s12033-019-00160-yDOI Listing
February 2019

Factor VII deficiency: do all need replacement for cardiac surgery?

Asian Cardiovasc Thorac Ann 2019 Jan 23;27(1):42-44. Epub 2017 Mar 23.

Department of Cardiothoracic Surgery, Dubai Hospital, Dubai, United Arab Emirates.

In cardiac surgery, supplementation with recombinant factor VIIa is the treatment of choice for patients with factor VII deficiency, but overzealous administration can be associated with thromboembolic side-effects. A 53-year-old man with factor VII activity 15.2%, international normalized ratio 2. Read More

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http://dx.doi.org/10.1177/0218492317702784DOI Listing
January 2019
1 Read

Cloning and molecular characterization of , a gene encoding a bread wheat ethylene response factor.

Mol Biol Res Commun 2018 Dec;7(4):153-163

Department of Crop Production and Plant Breeding, School of Agriculture, Shiraz University, Shiraz, Iran.

Ethylene response factor proteins are important for regulating gene expression under different stresses. Different isoforms for ERF have previously isolated from bread wheat ( L.) and related genera and called from to . Read More

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http://dx.doi.org/10.22099/mbrc.2018.30339.1336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363940PMC
December 2018

Metabolic Syndrome Severity Score in Korean Adults: Analysis of the 2010-2015 Korea National Health and Nutrition Examination Survey.

J Korean Med Sci 2019 Feb 29;34(6):e48. Epub 2019 Jan 29.

Institute of Genomic Cohort, Yonsei University, Wonju College of Medicine, Wonju, Korea.

Background: Continuous metabolic syndrome (MS) severity scores that can track metabolic risk in individuals over time have been developed for Western populations. The present study aimed to develop gender- and age-specific equations for MS severity scores in Korean adults.

Methods: Using data from the Korea National Health and Nutrition Examination Surveys (KNHANES) IV (2010-2012) and VI (2013-2015), we performed a confirmatory factor analysis of single MS factor that allowed for differential loadings across groups to generate gender- and age-specific, continuous MS severity scores. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374550PMC
February 2019
1.253 Impact Factor

A practical guide to optimization in X10 expansion microscopy.

Nat Protoc 2019 Mar;14(3):832-863

Institute of Science and Technology Austria, Klosterneuburg, Austria.

Expansion microscopy is a relatively new approach to super-resolution imaging that uses expandable hydrogels to isotropically increase the physical distance between fluorophores in biological samples such as cell cultures or tissue slices. The classic gel recipe results in an expansion factor of ~4×, with a resolution of 60-80 nm. We have recently developed X10 microscopy, which uses a gel that achieves an expansion factor of ~10×, with a resolution of ~25 nm. Read More

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http://www.nature.com/articles/s41596-018-0117-3
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http://dx.doi.org/10.1038/s41596-018-0117-3DOI Listing
March 2019
4 Reads

Kidney Transplant in a Patient With Factor VII Deficiency: Case Report.

Exp Clin Transplant 2019 01;17(Suppl 1):142-144

From the Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait.

Organ transplant in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Inherited factor VII deficiency is the most common of the rare bleeding disorders, with a wide set of hemorrhagic features. Although a kidney allograft is the most frequent type of solid-organ transplant, it is rarely performed in individuals with congenital hemorrhagic disorders. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P9DOI Listing
January 2019
1 Read

Hematopoietic Stem Cell Transplantation for Mucopolysaccharidoses: Past, Present, and Future.

Biol Blood Marrow Transplant 2019 Feb 14. Epub 2019 Feb 14.

Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware; Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan; Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan; Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Allogenic hematopoietic stem cell transplantation (HSCT) has proven to be a viable treatment option for a selected group of patients with mucopolysaccharidoses (MPS), including those with MPS types I, II, IVA, VI, and VII. Early diagnosis and timely referral to an expert in MPS are critical, followed by a complete examination and evaluation by a multidisciplinary team, including a transplantation physician. Treatment recommendations for MPS are based on multiple biological, sociological, and financial factors, including type of MPS, clinical severity, prognosis, present clinical signs and symptoms (disease stage), age at onset, rate of progression, family factors and expectations, financial burden, feasibility, availability, risks and benefits of available therapies such as HSCT, enzyme replacement therapy (ERT), surgical interventions, and other supportive care. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.012DOI Listing
February 2019
1 Read
3.404 Impact Factor

Characteristics Associated With Mortality in 372 Patients Receiving Low-Dose Recombinant Factor VIIa (rFVIIa) for Cardiac Surgical Bleeding.

J Cardiothorac Vasc Anesth 2019 Jan 22. Epub 2019 Jan 22.

Department of Anesthesiology, Division of Critical Care, Kansas University Medical Center, Kansas City, KS. Electronic address:

Objective: Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. This observational report analyzes the outcomes with use of a low dose and early administration of rFVIIa for cardiac surgical bleeding.

Design: A retrospective, observational study. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.01.047DOI Listing
January 2019
2 Reads

Recombinant Activated Factor VII in Children Undergoing Cardiac Surgery: Remember How and Why to Use It.

J Cardiothorac Vasc Anesth 2019 Jan 25. Epub 2019 Jan 25.

Division of Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1053/j.jvca.2019.01.052DOI Listing
January 2019
1 Read

Nanostructured cochleates: A multi-layered platform for cellular transportation of therapeutics.

Drug Dev Ind Pharm 2019 Feb 15:1-37. Epub 2019 Feb 15.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM's NMIMS , V. L. Mehta Road , Vile Parle (W), Mumbai , India.

Among lipid-based nanocarriers, multi-layered cochleates emerge as a novel delivery system because of prevention of oxidation of hydrophobic and hydrophilic drugs, enhancement in permeability and reduction in dose of drugs. It also improves oral bioavailability and increases the safety of a drug by targeting at a specific site with less side effects. Nanostructured cochleates are used as a carrier for the delivery of water-insoluble or hydrophobic drugs of anti-cancer, antiviral and anti-inflammatory action. Read More

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http://dx.doi.org/10.1080/03639045.2019.1583757DOI Listing
February 2019

Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.

Clin Pharmacol Drug Dev 2019 Feb 13. Epub 2019 Feb 13.

AstraZeneca, Gaithersburg, MD, USA.

Lesinurad is a selective uric acid reabsorption inhibitor approved for use in combination with xanthine oxidase inhibitors for the treatment of hyperuricemia associated with gout. In vitro, lesinurad was shown to be a weak inhibitor of cytochrome P450 (CYP)2C9 and a weak inducer of CYP3A4. Warfarin is a widely prescribed oral coumarin-based anticoagulant commonly prescribed in gout patients. Read More

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http://dx.doi.org/10.1002/cpdd.662DOI Listing
February 2019
2 Reads

Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders.

Cochrane Database Syst Rev 2019 02 13;2:CD009824. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Melaka Manipal Medical College, Bukit Baru, Jalan Batu, Hampar, Melaka, Malaysia, 75150.

Background: Congenital bleeding disorders can cause obstetric haemorrhage during pregnancy, labour and following delivery. Desmopressin acetate (DDAVP) is found to be an effective drug which can reduce the risk of haemorrhage and can also stop bleeding in certain congenital bleeding disorders. Its use in pregnancy has been controversial. Read More

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http://dx.doi.org/10.1002/14651858.CD009824.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373982PMC
February 2019
1 Read

Severe Intestinal Bleeding in a Woman with Glanzmann Thrombasthenia.

Eur J Case Rep Intern Med 2018 22;5(2):000796. Epub 2018 Feb 22.

Serviço de Medicina 2.1, Hospital dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Glanzmann thrombasthenia (GT) is a rare inherited disorder associated with abnormal platelet function. Non-surgical bleeding is common and can be life-threatening. A 70-year-old woman with GT presented with a 3 week history of melena and asthenia. Read More

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http://dx.doi.org/10.12890/2017_000796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346937PMC
February 2018
1 Read

Low endoscopy bleeding risk in patients with congenital bleeding disorders.

Haemophilia 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada.

Introduction: Haemophilia A and haemophilia B, von Willebrand disease (VWD), factor VII deficiency and factor XI deficiency are congenital bleeding disorders predisposing to bleeding during invasive procedures. The ageing population of people with congenital bleeding disorders will likely increasingly require gastrointestinal endoscopy. The bleeding risk postgastrointestinal endoscopy and optimal prophylactic treatment regimens are not well described. Read More

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http://doi.wiley.com/10.1111/hae.13691
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http://dx.doi.org/10.1111/hae.13691DOI Listing
February 2019
11 Reads

Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells.

J Thromb Haemost 2019 Feb 11. Epub 2019 Feb 11.

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

Essentials Prothrombotic extracellular vesicles (EV) carry agonist pathway-specific proteomes Agonists for protease activated receptor (PAR) 2 signaling have distinct effects on EV composition PAR2 signaling rapidly generates prothrombotic EV and slowly EV with inactive tissue factor (TF) FVIIa integrin ligation restricts TF incorporation into EV from endothelial cells SUMMARY: Background Cell injury signal-induced activation and release of tissue factor (TF) on extracellular vesicles (EVs) from immune and vessel wall cells propagate local and systemic coagulation initiation. TF trafficking and release on EVs occurs in concert with the release of cell adhesion receptors, including integrin β heterodimers, which control trafficking of the TF-activated factor VII (FVIIa) complex. Activation of the TF signaling partner, protease-activated receptor (PAR) 2, also triggers TF release on integrin β EVs from endothelial cells, but the physiological signals for PAR2-dependent EV generation at the vascular interface remain unknown. Read More

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http://dx.doi.org/10.1111/jth.14406DOI Listing
February 2019
2 Reads

Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure.

Neuroimage 2019 Apr 5;189:793-803. Epub 2019 Feb 5.

Experimental Psychology, University of Bristol, 12a Priory Road, BS8 1TU, UK.

Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38-71 years old). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.007DOI Listing
April 2019
1 Read

Time and age trends in smoking cessation in Europe.

PLoS One 2019 7;14(2):e0211976. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

Background: Smoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 and 2010. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211976PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366773PMC
February 2019
2 Reads

Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence.

Proc Natl Acad Sci U S A 2019 Feb 5;116(8):3300-3309. Epub 2019 Feb 5.

Agricultural Biotechnology Research Center, Academia Sinica, 11529 Taipei, Taiwan;

The rice gene, which encodes a group VII ethylene response factor (ERFVII), plays a pivotal role in rice survival under flooding stress, as well as other abiotic stresses. In , five ERFVII factors play roles in regulating hypoxic responses. A characteristic feature of ERFVIIs is a destabilizing N terminus, which functions as an N-degron that targets them for degradation via the oxygen-dependent N-end rule pathway of proteolysis, but permits their stabilization during hypoxia for hypoxia-responsive signaling. Read More

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http://dx.doi.org/10.1073/pnas.1818507116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386710PMC
February 2019
1 Read

Recombinant activated factor VII in neonatal cardiac surgery.

Eur J Cardiothorac Surg 2019 Jan 31. Epub 2019 Jan 31.

Paediatric Intensive Care Unit, The Children's Hospital at Westmead, Sydney, Australia.

Objectives: The aim of this study is to determine whether recombinant activated factor VII (rVIIa) was associated with thrombus formation in neonates undergoing cardiac surgery.

Methods: This is a retrospective study of neonates undergoing surgical repair of congenital cardiac lesions during a 9-year period.

Results: In our study, 416 cardiac operations requiring cardiopulmonary bypass (CPB) were performed on 414 neonates. Read More

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http://dx.doi.org/10.1093/ejcts/ezy483DOI Listing
January 2019
2 Reads

Gene-based FVIIa prophylaxis modulates the spontaneous bleeding phenotype of hemophilia A rats.

Blood Adv 2019 Feb;3(3):301-311

The Children's Hospital of Philadelphia, Philadelphia, PA.

A sizable proportion of hemophilia inhibitor patients fails immune tolerance induction and requires bypass agents for long-term bleed management. Recombinant human-activated coagulation Factor VII (rhFVIIa) is an on-demand bypass hemostatic agent for bleeds in hemophilia inhibitor patients. Prophylactic use of rhFVIIa may enable sustained hemostatic management of inhibitor patients, but the critical relationship of rhFVIIa circulating levels and clinical outcome in that setting remains unclear. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018027219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373746PMC
February 2019
3 Reads

Constrictive pericarditis in a patient with inherited factor VII deficiency.

Ter Arkh 2018 Aug;90(7):86-90

National Research Center for Hematology, Moscow, Russia.

Constrictive pericarditis (CP) is the final stage of a chronic inflammatory process characterized by fibrous thickening and calcification of the pericardium that impairs diastolic filling, reduces cardiac output, and ultimately leads to heart failure. We present a clinical case of CP in a patient with rare inherited bleeding disorder - factor VII deficiency. Heart failure due to CP was suspected based on clinical symptoms, results of ultrasonic and radiological investigations. Read More

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http://dx.doi.org/10.26442/terarkh201890786-90DOI Listing
August 2018
1 Read

4--Methylhonokiol Influences Normal Cardiovascular Development in Medaka Embryo.

Molecules 2019 Jan 29;24(3). Epub 2019 Jan 29.

Department of Biomolecular Sciences, Division of Pharmacology, University of Mississippi, University, MS 38677, USA.

Although 4--Methylhonokiol (MH) effects on neuronal and immune cells have been established, it is still unclear whether MH can cause a change in the structure and function of the cardiovascular system. The overarching goal of this study was to evaluate the effects of MH, isolated from , on the development of the heart and vasculature in a Japanese medaka model in vivo to predict human health risks. We analyzed the toxicity of MH in different life-stages of medaka embryos. Read More

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http://dx.doi.org/10.3390/molecules24030475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384692PMC
January 2019
1 Read

Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits.

Environ Sci Pollut Res Int 2019 Jan 26. Epub 2019 Jan 26.

Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.

The current study was performed to investigate the nephroprotective efficacy of Spirulina platensis (SP) and the possible benefits of combining SP and ascorbic acid (AA) in protecting against amikacin (AMK)-induced nephrotoxicity in rabbits. Forty-two male New Zealand rabbits were allocated to seven equal groups, receiving (I) normal saline as negative controls, (II) oral SP (500 mg/kg body weight), (III) oral AA (20 mg/kg bw), (IV) intramuscular AMK injection (100 mg/kg bw), (V) AMK plus SP, (VI) AMK plus AA, or (VII) AMK plus SP and AA at the aforementioned doses. The treatments were given once/day for 7 days. Read More

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http://dx.doi.org/10.1007/s11356-019-04249-4DOI Listing
January 2019
10 Reads
2.828 Impact Factor

Thrombospondin-1 Is a Major Activator of TGF-β Signaling in Recessive Dystrophic Epidermolysis Bullosa Fibroblasts.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

Mutations in the gene encoding collagen VII cause the devastating blistering disease recessive dystrophic epidermolysis bullosa (RDEB). RDEB is characterized by severe skin fragility and nonhealing wounds aggravated by scarring and fibrosis. We previously showed that TSP1 is increased in RDEB fibroblasts. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.011DOI Listing
January 2019
3 Reads

α-Carbonic anhydrases are strongly activated by spinaceamine derivatives.

Bioorg Med Chem 2019 Mar 21;27(5):800-804. Epub 2019 Jan 21.

Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

A series of 4-substituted-spinaceamine (4,5,6,7-tetrahydro-imidazolo[4,5-c]pyridine) were prepared from histamine and aromatic aldehydes Schiff bases, and investigated as activators of four human (h) carbonic anhydrase (CA, EC 4.2.1. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.01.017DOI Listing
March 2019
2.793 Impact Factor

Effects of coagulation factor VII polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients during the initiation and maintenance phases of warfarin therapy.

Pharmgenomics Pers Med 2019 14;12:1-8. Epub 2019 Jan 14.

Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan,

Purpose: This study aims to investigate the relationships between genetic polymorphisms of the coagulation factor VII (FVII) gene and warfarin responsiveness and sensitivity.

Patients And Methods: The study population consisted of 417 subjects (207 Jordanian cardiovascular patients and 210 healthy individuals). Cardiovascular patients were classified into two groups: those sensitive to warfarin dosage (sensitive, moderate, and resistant) and those responsive to warfarin based on International Normalized Ratios (INRs; poor, good, and extensive responders). Read More

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http://dx.doi.org/10.2147/PGPM.S189458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338106PMC
January 2019
2 Reads

Oxime Coupling of Active Site Inhibited Factor Seven with a Nonvolatile, Water-Soluble Fluorine-18 Labeled Aldehyde.

Bioconjug Chem 2019 Feb 6. Epub 2019 Feb 6.

Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Department of Biomedical Sciences , Rigshospitalet and University of Copenhagen , Copenhagen , DK-2100 , Denmark.

A nonvolatile fluorine-18 aldehyde prosthetic group was developed from [F]SFB, and used for site-specific labeling of active site inhibited factor VII (FVIIai). FVIIai has a high affinity for tissue factor (TF), a transmembrane protein involved in angiogenesis, proliferation, cell migration, and survival of cancer cells. A hydroxylamine N-glycan modified FVIIai (FVIIai-ONH) was used for oxime coupling with the aldehyde [F]2 under mild and optimized conditions in an isolated RCY of 4. Read More

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http://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00900
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http://dx.doi.org/10.1021/acs.bioconjchem.8b00900DOI Listing
February 2019
5 Reads

Canine factor VII deficiency: lessons learned in applying methods-based laboratory proficiency testing.

J Vet Diagn Invest 2019 Mar 19;31(2):276-279. Epub 2019 Jan 19.

Genetic Veterinary Sciences Inc., Paw Print Genetics, Spokane, WA.

Canine inherited factor VII deficiency is a mild-to-moderate, inherited coagulopathy that affects several breeds of dog. We identified 2 polymorphisms near the disease-causing F7 gene mutation, one of which interfered with testing in several Beagles by causing allele dropout of the normal, wild-type allele. In the absence of an external proficiency program among veterinary genetic testing laboratories, implementation of an internal proficiency program, which requires 2 independent methods for genotyping dogs at any given locus, was further enhanced by ensuring minimally non-overlapping primer pairs between the 2 assays. Read More

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http://dx.doi.org/10.1177/1040638718825281DOI Listing
March 2019
1 Read

Measurement of tissue factor activity in extracellular vesicles from human plasma samples.

Res Pract Thromb Haemost 2019 Jan 20;3(1):44-48. Epub 2018 Nov 20.

Division of Hematology and Oncology, Thrombosis and Hemostasis Program Department of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina.

Tissue factor (TF) is the cellular receptor for plasma factor (F) VII/FVIIa and triggers blood coagulation. Extracellular vesicles (EVs) are small membrane vesicles that are released from activated cells and tumor cells. Different cell types, including activated monocytes and tumors cells release TF-positive EVs into the circulation. Read More

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http://doi.wiley.com/10.1002/rth2.12165
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http://dx.doi.org/10.1002/rth2.12165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332748PMC
January 2019
5 Reads

Impact of Telemedicine Tools on Record Keeping and Compliance in Haemophilia Care.

Hamostaseologie 2019 Jan 17. Epub 2019 Jan 17.

Institute for Experimental Haematology and Transfusion Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany.

Background:  Record keeping is integral to home treatment for haemophilia. Issues with paper diaries include questionable compliance, data validity and quality. Implementation of electronic diaries (e-diaries) in haemophilia patients could improve documentation of home treatment. Read More

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http://dx.doi.org/10.1055/s-0038-1676128DOI Listing
January 2019

Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.

J Thromb Haemost 2019 Mar 13;17(3):470-481. Epub 2019 Feb 13.

Department of Biosciences, University of Salzburg, Salzburg, Austria.

Essentials Blood coagulation is driven by vitamin K (VK)-dependent proteases. We have identified and characterized 'sirtilin' as an additional VK-dependent protease. Sirtilins emerged early in the evolution of the coagulation system of vertebrates. Read More

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http://dx.doi.org/10.1111/jth.14384DOI Listing
March 2019
2 Reads

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

Blood 2019 Feb 14;133(9):967-977. Epub 2019 Jan 14.

Kaiser Permanente Washington Research Institute, Kaiser Permanente Washington, Seattle, WA.

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-05
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http://dx.doi.org/10.1182/blood-2018-05-849240DOI Listing
February 2019
20 Reads

Association between male pattern baldness and testicular germ cell tumor: a meta-analysis.

BMC Cancer 2019 Jan 11;19(1):53. Epub 2019 Jan 11.

The Second Hospital of Tianjin Medical University, Department of Urology, Tianjin Institute of Urology, No. 23 Pingjiang Road, Hexi District, Tianjin, People's Republic of China.

Background: The relationship between male pattern baldness and incidence of testicular cancer remains inconclusive. Hence, we performed the present meta-analysis based on all eligible case-control studies.

Methods: A comprehensive literature search was performed in July 30th 2018 based on PUBMED, EMBASE and Web of science database. Read More

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http://dx.doi.org/10.1186/s12885-018-5197-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329191PMC
January 2019
3 Reads

Screening for Hypertension and Obesity in Rural Population of Nepal.

Kathmandu Univ Med J (KUMJ) 2018 Jan.-Mar;16(61):4-7

Kathmandu Medical College, Sinamangal, Kathmandu, Nepal.

Background Hypertension is a major non-communicable disease and obesity is a risk factor for non-communicable diseases around the globe. The prevalence of hypertension and obesity is gradually increasing in Nepal. Most cases in the rural population of Nepal remain undiagnosed due to lack of routine screening and awareness. Read More

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February 2019
7 Reads