13,206 results match your criteria Factor VII

Investigation of a common canine factor VII deficiency variant in dogs with unexplained bleeding on autopsy.

J Vet Diagn Invest 2022 Aug 10:10406387221118581. Epub 2022 Aug 10.

Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.

The factor VII (FVII) protein is an integral component of the extrinsic coagulation pathway. Deleterious variants in the gene encoding this protein can result in factor VII deficiency (FVIID), a bleeding disorder characterized by abnormal (slowed) clotting with a wide range of severity, from asymptomatic to life-threatening. In canids, a single FVIID-associated variant, first described in Beagles, has been observed in 24 breeds and mixed-breed dogs. Read More

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Different predictive values of microvessel density for biochemical recurrence among different PCa populations: A systematic review and meta-analysis.

Cancer Med 2022 Aug 7. Epub 2022 Aug 7.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, PR China.

Background: Several studies have explored the relationship between intratumoral microvessel density (MVD) and the risk of postoperative biochemical recurrence (BCR) in prostate cancer (PCa), although the results are contradictory. Therefore, we conducted a meta-analysis to investigate the effect of MVD on BCR in PCa.

Method: We searched PubMed, MEDLINE, Science Direct/Elsevier, the Cochrane Library, CNKI, and EMBase databases from inception through January 2022, with no year or language restrictions, and used NOS guidelines to evaluate the quality of the 19 eligible studies. Read More

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Traboulsi syndrome caused by mutations in ASPH: An autosomal recessive disorder with overlapping features of Marfan syndrome.

Eur J Med Genet 2022 Jul 30:104572. Epub 2022 Jul 30.

Clinical Genetics Department, Nottingham University Hospitals NHS Trust, Nottingham, UK. Electronic address:

Traboulsi syndrome, otherwise known as facial dysmorphism, lens dislocation, anterior-segment abnormalities and spontaneous filtering blebs, is an autosomal recessive condition associated with characteristic ocular features including dislocated crystalline lenses, anterior segment abnormalities and in some individuals, non-traumatic conjunctival cysts. There is a distinctive facial appearance which includes flattened malar region with prominent beaked nose. Alterations in the aspartate beta-hydroxylase (ASPH) gene are known to be the cause of the condition. Read More

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High Prevalence of Congenital Factor VII (FVII) Deficiency in Adolescent Females with Heavy Menstrual Bleeding and Iron Deficiency Anemia.

J Pediatr Adolesc Gynecol 2022 Jul 30. Epub 2022 Jul 30.

Holtz Children's Hospital - Jackson Memorial Medical Center. Miami, FL; Division of Pediatric Hematology-Oncology, Department of Pediatrics. University of Miami - Miller School of Medicine. Miami, FL; University of Miami - Hemophilia Treatment Center. Mami, FL. Electronic address:

Study Objective: To examine the clinical characteristics and prevalence of congenital bleeding disorders (CBDs), with emphasis on congenital factor VII (FVII) deficiency and other rare bleeding disorders, in adolescent and young adult females referred to a Hemophilia Treatment Center (HTC) for evaluation and management of heavy menstrual bleeding (HMB) and iron deficiency anemia (IDA).

Design: This single-center retrospective study reviewed the clinical characteristics and prevalence of CBDs in post-menarcheal females, younger than 22-years-of-age, referred to an HTC from 2015 to 2021 for evaluation of HMB with or without IDA.

Results: One hundred females, mean age of 15 years (range 9 to 20 years), met initial study criteria with 95 included in the final analysis. Read More

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Differential Antivenom and Small-Molecule Inhibition of Novel Coagulotoxic Variations in and American Viperid Snake Venoms.

Toxins (Basel) 2022 Jul 26;14(8). Epub 2022 Jul 26.

Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia.

Within Neotropical pit-vipers, the Mexican/Central-American clade consisting of , , , and is a wide-ranging, morphologically and ecologically diverse group of snakes. Despite their prevalence, little is known of the functional aspects of their venoms. This study aimed to fill the knowledge gap regarding coagulotoxic effects and to examine the potential of different therapeutic approaches. Read More

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Design of a CHNHPbI/CsPbI-based bilayer solar cell using device simulation.

Heliyon 2022 Jul 14;8(7):e09941. Epub 2022 Jul 14.

Department of Physics, University of Lucknow, Lucknow, Uttar Pradesh 226007, India.

With lead-based light harvesters, perovskite solar cells (PSCs) have an efficiency of approximately 25.5%, making them a viable photovoltaic technology. The selection of the absorber materials for PSC in this work are (i) Cesium lead iodide (CsPbI) with a 1. Read More

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Phenotypic and genotypic characterization of two factor VII deficiency patients from southeastern China.

Blood Coagul Fibrinolysis 2022 Jul 22. Epub 2022 Jul 22.

Department of Hematology.

The congenital factor VII deficiency (FVIID) is a rare autosomal recessive haemorrhagic disease caused by mutations in the F7 gene. The aim of this study was to identify the mutations causing FVII deficiency and explain the genotype-phenotype association in two unrelated Chinese patients. Mutation detection was conducted by sequencing the whole F7 gene coding exons, exon-intron boundaries and the untranslated regions of 3' and 5'. Read More

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Molecular View into Preferential Binding of the Factor VII Gla Domain to Phosphatidic Acid.

Biochemistry 2022 Jul 19. Epub 2022 Jul 19.

Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Factor VII (FVII) is a serine protease with a key role in initiating the coagulation cascade. It is part of a family of vitamin K-dependent clotting proteins, which require vitamin K for formation of their specialized membrane-binding domains (Gla domains). Membrane binding of the FVII Gla domain is critical to the activity of FVII, mediating the formation of its complex with other clotting factors. Read More

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Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement.

Acta Pharm Sin B 2022 Apr 3;12(4):1928-1942. Epub 2021 Nov 3.

Engineering Research Center of Cell & Therapeutic Antibody, MOE, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

T cell engaging bispecific antibody (TCB) is an effective immunotherapy for cancer treatment. Through co-targeting CD3 and tumor-associated antigen (TAA), TCB can redirect CD3 T cells to eliminate tumor cells regardless of the specificity of T cell receptor. Tissue factor (TF) is a TAA that involved in tumor progression. Read More

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Prediction of adult post-hemorrhagic hydrocephalus: a risk score based on clinical data.

Sci Rep 2022 Jul 16;12(1):12213. Epub 2022 Jul 16.

Department of Neurosurgery, Jiangxi Provincial People's Hospital, Fenghe North Rd No. 266, Nanchang, 330000, Jiangxi Province, China.

There is lacking research on risk factors and prediction models associated with Post-hemorrhagic hydrocephalus (PHH). Thus, this present study aimed to analyze the risk factors of PHH and establish a risk-scoring system through a large-scale study. A retrospective study of 382 patients with intracranial hemorrhage assessed age, history and diagnosis, Glasgow coma score (GCS), and fever time. Read More

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Improvement of recombinant ADAMTS13 production through a more optimal signal peptide or an N-terminal fusion protein.

J Thromb Haemost 2022 Jul 16. Epub 2022 Jul 16.

Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Background: Recombinant human ADAMTS13 (rADAMTS13) is a key protein in fundamental research for investigating its mode of action and the pathophysiology of thrombotic thrombocytopenic purpura (TTP). However, the expression of rADAMTS13 is quite low in mammalian cells, which makes the production of the protein time-consuming and labor-intensive.

Objectives: We aimed at increasing the yield of rADAMTS13 by (1) using a more optimal signal peptide (SP) and (2) constructing an N-terminal fusion protein of ADAMTS13 with human serum albumin domain 1 (AD1-ADAMTS13). Read More

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Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy.

Clin Proteomics 2022 Jul 14;19(1):26. Epub 2022 Jul 14.

Department of Life Science, Graduate School of Engineering Science, Akita University, 1-1 Tegatagakuen-machi, Akita City, Akita, 010-8502, Japan.

Background: Anti-phospholipase A2 receptor autoantibody (PLA2R Ab)-associated membranous nephropathy (MN) is the most common form of primary MN (pMN). On the other hand, bucillamine (BCL), an antirheumatic drug developed in Japan, was reported to cause a rare form of secondary MN (sMN). Between these MN forms, comparative proteomic analysis of glomerular proteins has not been performed. Read More

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A bioartificial transgenic porcine whole liver expressing human proteins alleviates acute liver failure in pigs.

Hepatobiliary Pancreat Dis Int 2022 Jun 30. Epub 2022 Jun 30.

General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China. Electronic address:

Background: Preventing heterologous protein influx in patients is important when using xenogeneic bioartificial livers (BALs) to treat liver failure. The development of transgenic porcine livers synthesizing human proteins is a promising approach in this regard. Here, we evaluated the safety and efficacy of a transgenic porcine liver synthesizing human albumin (hALB) and coagulation factor VII (hFVII) within a bioartificial system. Read More

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Challenging treatment for refractory acquired haemophilia A complicated with severe severe acute respiratory coronavirus 2 infection.

Blood Coagul Fibrinolysis 2022 Jul 6. Epub 2022 Jul 6.

Complexo Hospitalario Universitario de A Coruña, Hospital Materno Infantil, A Coruña, Spain.

Immunosuppressive treatment and bypassing agents are used to treat acquired haemophilia A (AHA). On the other hand, COVID-19 infection induces a hypercoagulable state. Managing bleeding, risk of thrombosis, bypassing agents, active infection and immunosuppressive treatment can be challenging. Read More

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Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia: A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Transplant Cell Ther 2022 Jul 11. Epub 2022 Jul 11.

Hematology and Cellular Therapy Service, Hôpital Saint Antoine, AP-HP, Paris, France; INSERM, UMR 938, Paris, France.

Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. Read More

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Mechanisms and biomarkers of subcutaneous immunotherapy and sublingual immunotherapy in allergen immunotherapy.

Allergy Asthma Proc 2022 Jul;43(4):254-259

There are currently no biomarkers that can accurately predict clinical outcomes and segregate responders from nonresponders in allergen immunotherapy (AIT). Therefore, identifying a reliable predictive biomarker is essential to enable clinicians to tailor personalized therapy. New developments in AIT biomarkers are currently being explored, and it would be important to identify key areas of development and their feasibility for use in the clinic. Read More

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Neonatal haemostatic parameters in correlation to gestational age and birth weight.

Int J Lab Hematol 2022 Jul 11. Epub 2022 Jul 11.

Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, "Papageorgiou" Hospital, Thessaloniki, Greece.

Introduction: The aim of our study was to establish reference ranges for neonatal coagulation and fibrinolysis parameters and to investigate their relationship with gestational age (GA) and birth weight (BW).

Methods: A single-centre prospective study was conducted in all healthy neonates born in our hospital during the study period, excluding those with maternal or neonatal disorders and diseases that affect haemostasis. The following parameters were measured: fibrinogen, prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT) as well as factors II, V, VII, VIII, IX, X, XI and XII, von Willebrand (vWF), protein C, free protein S, antithrombin (AT), activated protein C resistance (APCr), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1). Read More

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Clinical phenotype and F7 gene genotype in 40 Tunisian patients with congenital factor VII deficiency.

Blood Coagul Fibrinolysis 2022 Jul 27;33(5):280-284. Epub 2022 Jun 27.

UR14ES11, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Congenital factor VII (FVII) deficiency is an autosomal recessive bleeding disorder characterized by a weak phenotypic and genotypic correlation. This study aimed to determine the genetic alterations of 40 Tunisian patients and to evaluate their relationships with the collected clinical and biological data. Forty FVII-deficient Tunisian patients have been included in this study. Read More

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Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology.

Neural Regen Res 2023 Jan;18(1):170-175

Department of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics; West China Brain Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

According to clinical statistics, the mortality of patients with early brainstem hemorrhage is high. In this study, we established rat models of brainstem hemorrhage by injecting type VII collagenase into the right basotegmental pontine and investigated the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological methods. We found that brainstem hematoma gradually formed in the injured rats over the first 3 days and then reduced after 7 days. Read More

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January 2023

The State of Microbiology Diagnostic of Prosthetic Joint Infection in Europe: An In-Depth Survey Among Clinical Microbiologists.

Front Microbiol 2022 20;13:906989. Epub 2022 Jun 20.

Institute of Hygiene and Environmental Medicine, Charité-Berlin University of Medicine, Berlin, Germany.

Background: This study aims to give an overview on how microbiology diagnosis tests of Prosthetic joint infections (PJI) is performed in Europe, and to explore whether any factor influences the decision on implementing a test.

Methods: An extensive online survey of clinical microbiologists from seven European countries (Belgium, Estonia, Germany, Italy, Netherlands, Switzerland, and Spain). Following items were assessed: (i). Read More

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Description and Clinical Management of Patients With Glanzmann's Thrombasthenia in a University Hospital, a Referral Center Specialized in Hemostasis, in Bogotá, Colombia.

Cureus 2022 Jun 4;14(6):e25657. Epub 2022 Jun 4.

Hematology, San Jose Hospital - University Foundation of Health Sciences, Bogotá, COL.

Introduction Glanzmann's thrombasthenia (GT) is an autosomal recessive disorder of platelets caused by a deficiency in the glycoprotein IIb-IIIa. Bleeding from the skin, mucous membranes, and ecchymosis are symptoms manifested starting in early childhood. There may also be major bleeding conditions as a result of surgical procedures or trauma. Read More

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COL8A1 Predicts the Clinical Prognosis of Gastric Cancer and Is Related to Epithelial-Mesenchymal Transition.

Biomed Res Int 2022 21;2022:7567447. Epub 2022 Jun 21.

Department of Pathology, School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Background: Gastric cancer (GC) is the fifth most common malignant tumor and the third leading cause of cancer-related deaths. Because GC has the characteristics of high heterogeneity, unclear mechanism, limited treatment methods, and low five-year survival rate, it is necessary to find the prognostic biomarkers of GC and explore the mechanism of GC.

Methods: We first identified differentially expressed genes (DEGs) between gastric cancer and normal gastric cells through expression analysis. Read More

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Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP.

Biochem J 2022 07;479(14):1559-1579

Rm-403/440, Structural Biology Lab, School of Life Sciences, Jawaharlal Nehru University, New Delhi 67, India.

The EccC enzyme of Mycobacterium tuberculosis ESX-1 secretion system is involved in EsxAB virulence factor secretion and offers an attractive target for antivirulence inhibitors development against M. tuberculosis. The EccCb1 polypeptide of the EccC enzyme contains two Ftsk/SpoIIIE type ATPase domains (D2 and D3) and binds to the EsxAB factor at the C-terminal region of the D3 domain. Read More

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LGBTQIA+ rights, mental health systems, and curative violence in India.

Indian J Med Ethics 2022 Apr-Jun;VII(2):127-133

Assistant Professor, Department of Psychology, CHRIST (Deemed-to-be) University, Bengaluru, INDIA.

This commentary examines the space-attitude-administrative complex of mainstream mental health systems with regard to its responses to decriminalisation of non-heteronormative sexual identities. Even though the Supreme Court, in its 2018 order, instructed governments to disseminate its judgment widely, there has been no such attempt till date. None of the government-run mental health institutions has initiated an LGBTQIA+ rights-based awareness campaign on the judgment, considering that lack of awareness about sexualities in itself remains a critical factor for a non-inclusive environment that forces queer individuals to end their lives. Read More

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Tissue factor: a neglected role in cancer biology.

J Thromb Thrombolysis 2022 Jul 28;54(1):97-108. Epub 2022 Jun 28.

The Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou, China.

Tissue factor (TF), an initiator of extrinsic coagulation pathway, is positively correlated with venous thromboembolism (VTE) of tumor patients. Beyond thrombosis, TF plays a vital role in tumor progression. TF is highly expressed in cancer tissues and circulating tumor cell (CTC), and activates factor VIIa (FVIIa), which increases tumor cells proliferation, angiogenesis, epithelial-mesenchymal transition (EMT) and cancer stem cells(CSCs) activity. Read More

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Genome-Wide Characterization and Comprehensive Analysis of NAC Transcription Factor Family in .

Front Genet 2022 8;13:901838. Epub 2022 Jun 8.

Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China.

NAC (NAM, ATAF, and CUC) is a ubiquitously expressed plant-specific transcription factor (TF) family which is involved in the regulation of various biological processes. However, a systematic characterization of gene family is yet to be reported in lotus. Here, 82 genes which included five predicted membrane-bound NAC proteins were identified in the lotus genome. Read More

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Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity.

iScience 2022 Jul 7;25(7):104547. Epub 2022 Jun 7.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.

Brown adipose tissue (BAT) has a role in maintaining systemic metabolic health in rodents and humans. Here, we show that metabolic stress induces BAT to produce coagulation factors, which then-together with molecules derived from the circulation-promote BAT dysfunction and systemic glucose intolerance. When mice were fed a high-fat diet (HFD), the levels of tissue factor, coagulation Factor VII (FVII), activated coagulation Factor X (FXa), and protease-activated receptor 1 (PAR1) expression increased significantly in BAT. Read More

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Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6.

J Mol Biol 2022 Aug 23;434(16):167697. Epub 2022 Jun 23.

Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada; Genome Sciences and Technology Program, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease primarily impacting motor neurons. Mutations in superoxide dismutase 1 (SOD1) are the second most common cause of familial ALS. Several of these mutations lead to misfolding or toxic gain of function in the SOD1 protein. Read More

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Extracellular vesicles from amniotic fluid, milk, saliva, and urine expose complexes of tissue factor and activated factor VII.

J Thromb Haemost 2022 Jun 24. Epub 2022 Jun 24.

Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Background: Tissue factor (TF) is expressed in the adventitia of the vessel wall and on extracellular vesicles (EVs) in body fluids. TF and activated coagulation factor (F) VII(a) together form the so-called extrinsic tenase complex, which initiates coagulation.

Aim: We investigated whether EVs in amniotic fluid, milk, saliva, and urine expose functional extrinsic tenase complexes that can trigger coagulation. Read More

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Procoagulant Activity in Amniotic Fluid Is Associated with Fetal-Derived Extracellular Vesicles.

Curr Issues Mol Biol 2022 Jun 13;44(6):2710-2716. Epub 2022 Jun 13.

Hemostasis Research Department, Dmitry Rogachev Pediatric Hematology and Immunology Hospital, Moscow 117997, Russia.

Procoagulant activity in amniotic fluid (AF) is positively correlated with phosphatidylserine (PS) and tissue factor (TF)-expressing(+) extracellular vesicles (EVs). However, it is unknown if pathological fetal conditions may affect the composition, phenotype, and procoagulant potency of EVs in AF. We sought to evaluate EV-dependent procoagulant activity in AF from pregnant people with fetuses with or without diagnosed chromosomal mutations. Read More

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