12,250 results match your criteria Factor VII


Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.

J Thromb Haemost 2019 Jan 15. Epub 2019 Jan 15.

Department of Biosciences, University of Salzburg, Billrothstr. 11, A-5020, Salzburg, Austria.

Background: Vitamin K (VK)-dependent proteases are major players in blood coagulation including the initiation as well as the regulation of the cascade. Five different members of this protease family have been described comprising the coagulation factors VII (FVII), IX (FIX), X (FX), protein C (PC) and prothrombin (FII). FVII, FIX, FX and PC share a typical domain architecture with a N-terminal Gla (γ-carboxyglutamate)-domain, two EGF (epidermal growth factor-like)-domains and a C-terminal trypsin-like serine protease (SP)-domain. Read More

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http://dx.doi.org/10.1111/jth.14384DOI Listing
January 2019

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

Blood 2019 Jan 14. Epub 2019 Jan 14.

Department of Epidemiology, University of Washington, Seattle, WA, United States.

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of nine genome-wide association studies of plasma FVII levels (seven FVII activity and two FVII antigen) among 27,495 participants of European and African ancestry. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-05
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http://dx.doi.org/10.1182/blood-2018-05-849240DOI Listing
January 2019
1 Read

Association between male pattern baldness and testicular germ cell tumor: a meta-analysis.

BMC Cancer 2019 Jan 11;19(1):53. Epub 2019 Jan 11.

The Second Hospital of Tianjin Medical University, Department of Urology, Tianjin Institute of Urology, No. 23 Pingjiang Road, Hexi District, Tianjin, People's Republic of China.

Background: The relationship between male pattern baldness and incidence of testicular cancer remains inconclusive. Hence, we performed the present meta-analysis based on all eligible case-control studies.

Methods: A comprehensive literature search was performed in July 30th 2018 based on PUBMED, EMBASE and Web of science database. Read More

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http://dx.doi.org/10.1186/s12885-018-5197-5DOI Listing
January 2019

Impact of a multicomponent physical activity intervention on cognitive performance: the MOVI-KIDS Study.

Scand J Med Sci Sports 2019 Jan 11. Epub 2019 Jan 11.

Universidad de Castilla-La Mancha, Social and Health Care Research Center. C/ Santa Teresa Jornet s/n, 16071, Cuenca, Spain.

Introduction: This study examined the impact of a multicomponet physical activity (PA) intervention (MOVI-KIDS) on improving cognition in schoolchildren. This paper also analyzed the mediator role of motor fitness between MOVI-KIDS and cognition.

Methods: Propensity score analysis of data from a cluster randomized controlled trial (MOVI-KIDS study). Read More

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http://doi.wiley.com/10.1111/sms.13383
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http://dx.doi.org/10.1111/sms.13383DOI Listing
January 2019
1 Read

Screening for Hypertension and Obesity in Rural Population of Nepal.

Kathmandu Univ Med J (KUMJ) 2018 Jan.-Mar;16(61):4-7

Kathmandu Medical College, Sinamangal, Kathmandu, Nepal.

Background Hypertension is a major non-communicable disease and obesity is a risk factor for non-communicable diseases around the globe. The prevalence of hypertension and obesity is gradually increasing in Nepal. Most cases in the rural population of Nepal remain undiagnosed due to lack of routine screening and awareness. Read More

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January 2019

Functionally oriented analysis of cardiometabolic traits in a trans-ethnic sample.

Hum Mol Genet 2019 Jan 8. Epub 2019 Jan 8.

Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN.

Interpretation of genetic association results is difficult because signals often lack biological context. To generate hypotheses of the functional genetic etiology of complex cardiometabolic traits, we estimated the genetically determined component of gene expression from common variants using PrediXcan (1) and determined genes with differential predicted expression by trait. PrediXcan imputes tissue-specific expression levels from genetic variation using variant-level effect on gene expression in transcriptome data. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddy435DOI Listing
January 2019
1 Read

Management of antiplatelet therapy for non-elective invasive procedures or bleeding complications: Proposals from the French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Thrombosis and Haemostasis (GFHT), in collaboration with the French Society for Anaesthesia and Intensive Care (SFAR).

Arch Cardiovasc Dis 2019 Jan 5. Epub 2019 Jan 5.

Service d'angiologie et d'hémostase, département de spécialités de médecine, hôpitaux universitaires de Genève, 1205 Genève, Switzerland; Geneva Platelet Group, faculté de médecine, université de Genève, 1205 Genève, Switzerland.

The French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Haemostasis and Thrombosis (GFHT), in collaboration with the French Society for Anaesthesia and Intensive Care (SFAR), drafted up-to-date proposals on the management of antiplatelet therapy for non-elective invasive procedures or bleeding complications. The proposals were discussed and validated by a vote; all proposals could be assigned with a high strength. Management of oral antiplatelet agents in emergency settings requires knowledge of their pharmacokinetic and pharmacodynamic parameters, evaluation of the degree of alteration of haemostatic competence and the associated bleeding risk. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.10.004DOI Listing
January 2019

Administration of rFVIIa to concizumab-dosed monkeys is safe and concizumab does not affect the potency of rFVIIa in hemophilic rabbits.

J Thromb Haemost 2019 Jan 7. Epub 2019 Jan 7.

Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.

Background: Concizumab, a monoclonal antibody against tissue factor pathway inhibitor (TFPI), is currently in clinical development as a subcutaneous prophylactic therapy for hemophilia A/B with and without inhibitors. In patients with inhibitors, treatment choice for break-through bleeding will be bypassing agents, e.g. Read More

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http://dx.doi.org/10.1111/jth.14380DOI Listing
January 2019

Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis.

Exp Gerontol 2019 Jan 2;118:1-8. Epub 2019 Jan 2.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. Electronic address:

Background: Mice deficient in the circadian clock gene BMAL1 (Brain and Muscle ARNT-like protein-1) exhibit a hypercoagulable state and an enhanced arterial and venous thrombogenicity, which aggravates with age. We investigated the effect of BMAL1 deficiency in mice at a different age on the diurnal rhythm of factors involved in coagulation and fibrinolysis.

Materials And Methods: Hepatic, cardiac and brain tissues were isolated from 10- and 25-weeks-old Bmal1-deficient (BMAL1) and wild-type (BMAL1) mice at ZT2 and at ZT14 to analyze the mRNA expression level of genes involved in coagulation and fibrinolysis. Read More

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http://dx.doi.org/10.1016/j.exger.2018.12.017DOI Listing
January 2019

Efficacy and Safety of Recombinant Activated Factor VII Off-label Use in a Pediatric Hematology/Oncology Cohort.

J Pediatr Hematol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Departments of Hematology.

Background: Recombinant activated factor VII (rFVIIa) has been used off-label to treat or prevent severe bleeding in patients for whom conventional treatments are unsuccessful. However, studies in children remain limited.

Procedure: To examine the efficacy and safety of rFVIIa, we performed a retrospective analysis of rFVIIa off-label use in a pediatric hematology/oncology cohort at a single center from 2006 to 2014. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001379DOI Listing
January 2019

Buyang Huanwu Decoction () Attenuates Glial Scar by Downregulating the Expression of Leukemia Inhibitory Factor in Intracerebral Hemorrhagic Rats.

Chin J Integr Med 2018 Dec 28. Epub 2018 Dec 28.

Medical College of China Three Gorges University, Yichang, Hubei Province, 443002, China.

Objective: To evaluate the effect of Buyang Huanwu Decoction (, BYHWD) on glial scar after intracerebral hemorrhage (ICH) and investigate the underlying mechanism.

Methods: Collagenase type VII (0.5 U) was injected stereotaxically into right globus pallidus to induce ICH model. Read More

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http://dx.doi.org/10.1007/s11655-018-2917-7DOI Listing
December 2018

Apolipoprotein C-III Strongly Correlates with Activated Factor VII-Anti-Thrombin Complex: An Additional Link between Plasma Lipids and Coagulation.

Thromb Haemost 2019 Jan 2. Epub 2019 Jan 2.

Department of Medicine, University of Verona, Verona, Italy.

Activated factor VII-anti-thrombin (FVIIa-AT) complex is a potential biomarker of pro-thrombotic diathesis reflecting FVIIa-tissue factor (TF) interaction and has been associated with mortality in patients with coronary artery disease (CAD). Previous data indicated plasma lipids as predictors of FVIIa-AT variability, and plasma lipoproteins as potential stimulators of the coagulation cascade. Our aim was to evaluate the relationships between FVIIa-AT plasma concentration and a broad apolipoprotein profile (including ApoA-I, ApoB, ApoC-III and ApoE). Read More

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http://dx.doi.org/10.1055/s-0038-1676817DOI Listing
January 2019
1 Read

Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients.

Thromb Haemost 2019 Jan 31;119(1):117-127. Epub 2018 Dec 31.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction:  Glanzmann thrombasthenia (GT) is a rare bleeding disorder. The disease is caused by the lack or dysfunction of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3) which is essential for platelet aggregation. Bleeding episodes are usually managed by platelet transfusions. Read More

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http://dx.doi.org/10.1055/s-0038-1676348DOI Listing
January 2019
2 Reads

[Effects of 37 centigrade volume resuscitation on coagulation function and blood lactic acid in neonates with septic shock].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1146-1149

Department of Pediatrics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, China (Zhong XM, Zhong M, Luo KY, Liao HQ, Wang HB); Department of Laboratory, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, China (Shen ZM); Department of Pediatrics, People's Hospital of Huichang County, Ganzhou 341000, Jiangxi, China (Tu Q). Corresponding author: Zhong Xiaoming, Email:

Objective: To investigate the effect of volume resuscitation with normal saline (NS) at 37 centigrade on the coagulation function and microcirculation of neonates with septic shock.

Methods: Children with septic shock admitted to neonatal intensive care unit (NICU) of the First Affiliated Hospital of Gannan Medical University were enrolled. Twenty-four newborns with septic shock were divided into two groups by random number table method (12 in each group), and were resuscitated with 10 mL/kg at 25 centigrade NS and 37 centigrade NS respectively on the basis of routine treatment. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.009DOI Listing
December 2018

Successful coronary artery bypass graft surgery in severe congenital factor VII deficiency: Perioperative treatment with pd-factor VII concentrate.

Haemophilia 2018 Dec 27. Epub 2018 Dec 27.

Division of Haematology, A.O.U. Policlinico Vittorio Emanuele, Catania, Italy.

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http://dx.doi.org/10.1111/hae.13657DOI Listing
December 2018
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Inhibitor development in patients with congenital factor VII deficiency, a study on 50 Iranian patients.

Blood Coagul Fibrinolysis 2018 Dec 21. Epub 2018 Dec 21.

Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences.

: Congenital factor VII (FVII) deficiency is a rare bleeding disorder with an estimated prevalence of 1 per 500 000 in the general population. On-demand replacement therapy is the main therapeutic choice in patients with congenital FVII deficiency. Inhibitor formation against exogenous FVII is very rare and can cause challenges in the management of the disorder. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000791DOI Listing
December 2018
1.380 Impact Factor

Reversal of Novel Anticoagulants in Emergent Surgery and Trauma; a Comprehensive Review and Proposed Management Algorithm.

Curr Pharm Des 2018 Dec 26. Epub 2018 Dec 26.

First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens. Greece.

Non-vitamin K oral anticoagulants (NOACs), including dabigatran, rivaroxaban, apixaban, and edoxaban, are increasingly used for thromboembolism prevention. Contrary to older anticoagulants, such as coumadin, where antidotes existed and were broadly used in cases of emergent surgery and bleeding, antidotes for NOACs have not been developed until recently. Moreover, the monitoring of NOAC's anticoagulant effect varies across different hospital settings and the absence of a single test that can accurately predict the degree of anticoagulation achieved increases the uncertainty. Read More

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http://www.eurekaselect.com/168587/article
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http://dx.doi.org/10.2174/1381612825666181226150629DOI Listing
December 2018
4 Reads

A clinical, proteomics, and artificial intelligence-driven model to predict acute kidney injury in patients undergoing coronary angiography.

Clin Cardiol 2018 Dec 23. Epub 2018 Dec 23.

Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

Background: Standard measures of kidney function are only modestly useful for accurate prediction of risk for acute kidney injury (AKI).

Hypothesis: Clinical and biomarker data can predict AKI more accurately.

Methods: Using Luminex xMAP technology, we measured 109 biomarkers in blood from 889 patients prior to undergoing coronary angiography. Read More

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http://dx.doi.org/10.1002/clc.23143DOI Listing
December 2018
1 Read

Eptacog beta: a novel recombinant human factor VIIa for the treatment of hemophilia A and B with inhibitors.

Expert Rev Hematol 2018 Dec 21. Epub 2018 Dec 21.

a Haemophilia Treatment Centre, University Hospital Montpellier , France .

Introduction: Hemophilia A and B are X-linked recessive disorders caused by the deficiency of factor VIII or factor IX, respectively. Bleeding episodes are treated with factor replacement therapy. The most serious complication of this treatment is the development of inhibitors. Read More

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http://dx.doi.org/10.1080/17474086.2019.1560259DOI Listing
December 2018
1 Read

Continuous infusion of recombinant activated factor VII: a review of data in congenital hemophilia with inhibitors and congenital factor VII deficiency.

J Blood Med 2018 29;9:227-239. Epub 2018 Nov 29.

Clinical, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA.

Introduction: Continuous infusion (CI) of clotting factors as a replacement therapy for perioperative hemostatic protection has been performed for many years, including with factors VIII and IX and recombinant activated factor VII (rFVIIa). This approach provides steady factor levels without requiring frequent administration of bolus doses.

Aim: To review safety, efficacy, and dosing data regarding CI of rFVIIa for hemostatic management of patients with congenital hemophilia with inhibitors (CHwI) or congenital factor VII deficiency (C7D). Read More

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http://dx.doi.org/10.2147/JBM.S184040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276614PMC
November 2018
1 Read

Constrained α-Helical Peptides as Inhibitors of Protein-Protein and Protein-DNA Interactions.

Biomedicines 2018 Dec 18;6(4). Epub 2018 Dec 18.

Department of Biophysics, Bose Institute, P1/12 CIT Scheme VII M, Kolkata 700054, India.

Intracellular regulatory pathways are replete with protein-protein and protein-DNA interactions, offering attractive targets for therapeutic interventions. So far, most drugs are targeted toward enzymes and extracellular receptors. Protein-protein and protein-DNA interactions have long been considered as "undruggable". Read More

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http://www.mdpi.com/2227-9059/6/4/118
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http://dx.doi.org/10.3390/biomedicines6040118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315407PMC
December 2018
3 Reads

Constitutive expression of a stabilized transcription factor ERFVII enhances waterlogging tolerance in wheat without penalizing grain yield.

Plant Cell Environ 2018 Dec 19. Epub 2018 Dec 19.

The National Key Facility for Crop Gene Resources and Genetic Improvement, Key Laboratory of Biology and Genetic Improvement of Triticeae Crops, Ministry of Agriculture, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Waterlogging causes oxygen deprivation within plant roots and affects crop growth and yield. In crop wheat (Triticum aestivum), molecular responses to waterlogging are poorly understood. Here, we performed a genome-wide analysis of group VII ethylene response factor (ERF) genes in hexaploid wheat and identified 25 genes, which were induced by waterlogging with diverse manner. Read More

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http://doi.wiley.com/10.1111/pce.13505
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http://dx.doi.org/10.1111/pce.13505DOI Listing
December 2018
3 Reads

Effects of attachment to and participation in the community on motivation to participate in dementia prevention and support activities: analysis of Web survey data.

Psychogeriatrics 2018 Nov 22. Epub 2018 Nov 22.

Education and Innovation Center, National Center for Geriatrics and Gerontology, Aichi, Japan.

Aim: The objective of this study was to elucidate the effects of a sense of attachment to the community (attachment) and participation in community activities (participation) on motivation to participate in dementia prevention and support activities (motivation).

Methods: We conducted a nationwide Web-based questionnaire survey of 1693 men and women aged ≥20 years. The questionnaire items used in the analysis asked about the following: (i) demographic characteristics (i. Read More

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http://dx.doi.org/10.1111/psyg.12388DOI Listing
November 2018
1 Read

Treatment of rare factor deficiencies other than hemophilia.

Blood 2018 Dec 17. Epub 2018 Dec 17.

Universita degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

The deficiency of fibrinogen, prothrombin, factor V, VII, VIII, IX, X, XI and XIII, called rare coagulation disorders (RCDs), may result in coagulopathies leading to spontaneous or post-trauma and post-surgery hemorrhages. RCDs are characterized by a wide variety of symptoms, from mild to severe, which can vary significantly from one disease to another and from one patient to another. The most typical symptoms of all RCDs are mucosal bleedings and bleeding at the time of invasive procedures, while other life-threatening symptoms such as central nervous system bleeding and hemarthroses are mostly present only in some deficiencies (afibrinogenemia, FX and FXIII). Read More

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http://dx.doi.org/10.1182/blood-2018-06-820738DOI Listing
December 2018
1 Read

Functional and Molecular Characterization of C91S Mutation in the Second Epidermal Growth Factor-Like Domain of Factor VII.

Iran J Biotechnol 2018 Apr 18;16(1):e1813. Epub 2018 Apr 18.

Department of Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Coagulation Factor VII is a vitamin K-dependent serine protease which has a pivotal role in the initiation of the coagulation cascade. The congenital Factor VII deficiency is a recessive hemorrhagic disorder that occurs due to mutations of gene. In the present study C91S (p. Read More

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http://www.ijbiotech.com/article_58484.html
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http://dx.doi.org/10.21859/ijb.1813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217260PMC
April 2018
3 Reads

Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3.

Front Physiol 2018 28;9:1623. Epub 2018 Nov 28.

Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.

Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate (IS), which are currently considered as a non-classical CKD-specific risk factor for CVDs. The present study aimed to examine the effect of chronic exposure to IS on the hemostatic system and arterial thrombosis in a model without greater interferences from the uremic milieu consisting of additional uremic toxins. Read More

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http://dx.doi.org/10.3389/fphys.2018.01623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279869PMC
November 2018

The Comparative Treatment of Intraventricular Chemotherapy by Ommaya Reservoir vs. Lumbar Puncture in Patients With Leptomeningeal Carcinomatosis.

Front Oncol 2018 20;8:509. Epub 2018 Nov 20.

Emergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.

Leptomeningeal Carcinomatosis (LCM) represents a state of systemic malignant disease with poor prognosis. The purpose of this study is to compare overall survival (OS) between intraventricular chemotherapy through Ommaya reservoir (OR) and chemotherapy through lumbar puncture (LP) in LCM. Forty adult patients with LCM were included. Read More

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http://dx.doi.org/10.3389/fonc.2018.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256195PMC
November 2018
1 Read

Nitrate nutrition influences multiple factors in order to increase energy efficiency under hypoxia in Arabidopsis.

Ann Bot 2018 Dec 10. Epub 2018 Dec 10.

National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi, India.

Background And Aims: Nitrogen (N) levels vary between ecosystems, while the form of available N has a substantial impact on growth, development and perception of stress. Plants have the capacity to assimilate N in the form of either nitrate (NO3-) or ammonium (NH4+). Recent studies revealed that NO3- nutrition increases nitric oxide (NO) levels under hypoxia. Read More

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http://dx.doi.org/10.1093/aob/mcy202DOI Listing
December 2018

Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosa.

Matrix Biol 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy. Electronic address:

Loss-of-function mutations in the gene encoding type VII collagen underlie recessive dystrophic epidermolysis bullosa (RDEB), a disease characterized by skin and mucosal blistering, impaired wound healing, and diffuse dermal inflammation and fibrosis. Transforming growth factor-β signaling plays a crucial role in determining RDEB fibrotic microenvironment that leads to the development of disabling secondary disease manifestations, including hand and foot deformities. Experimental findings indicate that expression levels of decorin, a small leucine-rich proteoglycan and an endogenous TGF-β inhibitor, can modulate RDEB disease phenotype by contrasting dermal fibroblast fibrotic behavior. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X183043
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http://dx.doi.org/10.1016/j.matbio.2018.12.001DOI Listing
December 2018
1 Read

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183076
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http://dx.doi.org/10.1016/j.pan.2018.11.013DOI Listing
November 2018
5 Reads

Probable Roles of Coagulation Cascade and Fibrinolysis System in the Development of Allergic Rhinitis.

Am J Rhinol Allergy 2018 Dec 6:1945892418816015. Epub 2018 Dec 6.

3 Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. Read More

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http://dx.doi.org/10.1177/1945892418816015DOI Listing
December 2018
1 Read

Pseudane-VII Regulates LPS-Induced Neuroinflammation in Brain Microglia Cells through the Inhibition of iNOS Expression.

Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.

Department of Life Science, Immunology Research Lab, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University, Dong-gu, Gwangju 61452, Korea.

We previously isolated pseudane-VII from the secondary metabolites of sp. M2 in marine water, and demonstrated its anti-inflammatory efficacy on macrophages. However, the molecular mechanism by which pseudane-VII suppresses neuroinflammation has not yet been elucidated in brain microglia. Read More

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http://www.mdpi.com/1420-3049/23/12/3196
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http://dx.doi.org/10.3390/molecules23123196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320864PMC
December 2018
5 Reads

FranceCoag: a 22-year prospective follow-up of the national French cohort of patients with inherited bleeding disorders.

Eur J Epidemiol 2018 Dec 5. Epub 2018 Dec 5.

Haemophilia Treatment Centre, APHM, Children Hospital La Timone, Aix Marseille University, INSERM, INRA, C2VN, Marseille, France.

FranceCoag is an ongoing open prospective multicentre cohort project aimed at improving epidemiological knowledge about inherited bleeding disorders in France. The main objective of this article was to evaluate the project's progress as of the 30th December 2016. Between 1994 and this date, of the 10,047 patients included in the study, 384 (3. Read More

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http://link.springer.com/10.1007/s10654-018-0468-7
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http://dx.doi.org/10.1007/s10654-018-0468-7DOI Listing
December 2018
4 Reads

Takayasu Arteritis Presenting as Renovascular Hypertension and Renal Failure in a Patient with Factor VII Deficiency.

Eurasian J Med 2018 Oct;50(3):210-212

Department of Cardiology, Istanbul Medeniyet University School of Medicine, İstanbul, Turkey.

A 23-year-old female patient with factor VII (FVII) deficiency was admitted with severe hypertension and renal failure. Brachial arterial pressures were 230/120 and 220/115 mm/Hg on the right and left arms, respectively. There was no blood pressure difference between the arms. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2018.17324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263223PMC
October 2018
2 Reads

AP2/ERF Family Transcription Factors ORA59 and RAP2.3 Interact in the Nucleus and Function Together in Ethylene Responses.

Front Plant Sci 2018 19;9:1675. Epub 2018 Nov 19.

Department of Life Sciences, Korea University, Seoul, South Korea.

The gaseous plant hormone ethylene is a key signaling molecule regulating plant growth, development, and defense against pathogens. Octadecanoid-responsive arabidopsis 59 (ORA59) is an ethylene response factor (ERF) transcription factor and has been suggested to integrate ethylene and jasmonic acid signaling and regulate resistance to necrotrophic pathogens. Here we screened for ORA59 interactors using the yeast two-hybrid system to elucidate the molecular function of ORA59. Read More

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http://dx.doi.org/10.3389/fpls.2018.01675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254012PMC
November 2018

Phenotypical variability in congenital FVII deficiency follows the ISTH-SSC severity classification guidelines: a review with illustrative examples from the clinic.

J Blood Med 2018 19;9:211-218. Epub 2018 Nov 19.

Clinical Development, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA.

Background: One of the most common rare inherited bleeding disorders, congenital factor VII (FVII) deficiency typically has a milder bleeding phenotype than other rare bleeding disorders. Categorizing severity in terms of factor activity associated with hemophilia (severe <1%, moderate 1%-5%, mild 6%-40%) has led to the observation that bleeding phenotype does not follow closely with FVII activity. Over the past decade, large-scale global registries have investigated bleeding phenotype more thoroughly. Read More

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http://dx.doi.org/10.2147/JBM.S157633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250109PMC
November 2018
2 Reads

Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in .

Proc Natl Acad Sci U S A 2018 Dec 3;115(51):E12101-E12110. Epub 2018 Dec 3.

Institute of Biology I, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany;

Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining () energy-dependent changes in the composition of the acyl-CoA pool and () the cellular oxygen concentration. Read More

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http://dx.doi.org/10.1073/pnas.1809429115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304976PMC
December 2018

Beneficial Effect of U-74389 G and Sildenafil in An Experimental Model of Flap Ischemia/Reperfusion Injury in Swine. Histological and Biochemical Evaluation of the Model.

J Invest Surg 2018 Nov 30:1-13. Epub 2018 Nov 30.

e Experimental - Research Center , ELPEN , Athens , Greece.

Purpose Of The Study: Tissue reconstruction after burns, tumor excisions, infections or injuries is a frequent surgical challenge to avoid Ischemia-reperfusion injury. Lazaroids and sildenafil, through their mechanisms of action, have been studied for their protective effects on various organs subjected to IRI. In this study, we aimed to evaluate the therapeutic potential of U-74389G and sildenafil in a swine model of ischemia and reperfusion injury of latissimus dorsi flap. Read More

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http://dx.doi.org/10.1080/08941939.2018.1524527DOI Listing
November 2018

aPCC vs. rFVIIa for the treatment of bleeding in patients with acquired haemophilia - a cost-effectiveness model.

Vox Sang 2018 Nov 30. Epub 2018 Nov 30.

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background: Acquired haemophilia A (AHA) is an autoimmune bleeding disorder with significant morbidity and mortality. Bleeding AHA patients with high titre inhibitors can be treated with either activated prothrombin complex concentrate (aPCC) or recombinant activated factor VII (rFVIIa). Given that both replacement therapies have inherent benefits and limitations, a cost-effectiveness analysis (CEA) was performed in this population to compare rFVIIa with aPCC. Read More

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http://dx.doi.org/10.1111/vox.12726DOI Listing
November 2018
2 Reads

Recombinant activated factor VII (rFVIIa) in refractory haemorrhage for non-haemophiliacs: an eleven-year single-centre experience.

BMC Hematol 2018 23;18:34. Epub 2018 Nov 23.

1Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, PNG Malaysia.

Background: Massive bleeding is one of the commonest salvageable causes of death. The search for an ideal haemostatic agent during massive bleeding is still ongoing. One of the novel haemostatic medications is recombinant activated factor VII (rFVIIa). Read More

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http://dx.doi.org/10.1186/s12878-018-0126-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251212PMC
November 2018
9 Reads

Hypocoagulability and Platelet Dysfunction Are Exacerbated by Synthetic Colloids in a Canine Hemorrhagic Shock Model.

Front Vet Sci 2018 13;5:279. Epub 2018 Nov 13.

School of Veterinary and Life Sciences, College of Veterinary Medicine, Murdoch University Perth, WA, Australia.

Hemorrhagic shock and volume replacement can alter coagulation. Synthetic colloids, hydroxyethyl starch (HES), and gelatin, may enhance hypocoagulability. Our primary objective was to describe the effect of four fluid products on coagulation in canine hemorrhagic shock. Read More

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http://dx.doi.org/10.3389/fvets.2018.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243100PMC
November 2018
1 Read

Acquired Factor VII Deficiency in Association with Pyelonephritis.

J Assoc Physicians India 2018 May;66(5):97-98

Junior Resident, SGRD-IMSAR, Sri Amritsar, Punjab.

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May 2018
1 Read

Investigation of potential biomarkers for thrombosis related diseases in Turkish Cypriot population.

Authors:
M C Ergoren P Tulay

Int J Biol Macromol 2019 Mar 19;124:515-518. Epub 2018 Nov 19.

Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, North Cyprus Mersin 10, Turkey. Electronic address:

Genetic and environmental factors are involved in development of many diseases. The allelic frequencies may differ in different populations and in different ethnic groups. The aim of this study was to investigate the genotypes of MTHFR and factor VII polymorphisms and to identify biomarkers for thrombosis related diseases in Turkish Cypriot population. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.11.176DOI Listing

Crosstalk between TF/FVIIa and EGFR signaling in colorectal cancer cells.

Cancer Biol Ther 2018 Nov 21:1-7. Epub 2018 Nov 21.

a Department of General Surgery , Peking University First Hospital , Beijing , China.

TF/FVIIa (Tissue Factor/Active Coagulation factor VII) and EGFR (Epidermal Growth Factor Receptor) signaling both promote malignant progression of colorectal cancer. However, the crosstalk of these two signaling pathways in human colorectal cancer cells remains unclear. Here we detected the changes of mRNA profile in human colorectal cancer cell SW620 exposed to FVIIa. Read More

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http://dx.doi.org/10.1080/15384047.2018.1529123DOI Listing
November 2018
11 Reads

Evaluating the safety of emicizumab in patients with hemophilia A.

Expert Opin Drug Saf 2018 Dec 28;17(12):1233-1237. Epub 2018 Nov 28.

a Division of Hematology/Oncology , Icahn School of Medicine , New York , NY , USA.

Introduction: Patients affected by hemophilia A often require frequent prophylactic and therapeutic self-infusion. For those who develop inhibitors, treatment options are limited and mortality is increased. Emicizumab, a bispecific antibody to Factors IXa and X that carries out the function of Factor VIII (FVIII), represents a novel therapeutic approach. Read More

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http://dx.doi.org/10.1080/14740338.2019.1551356DOI Listing
December 2018
6 Reads

The carboxyl-terminal region of human coagulation factor X as a natural linker for fusion strategies.

Thromb Res 2019 Jan 9;173:4-11. Epub 2018 Nov 9.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address:

Fusion with human serum albumin (HSA), which represents a well-established technique to extend half-life of therapeutic proteins, commonly exploits intervening peptide linkers as key components. Here, we explored the human coagulation factor X (FX) carboxyl-terminal region, previously demonstrated by us to be dispensable for secretion and coagulant activity, as a natural linker for fusion purposes. To test our hypothesis, we compared direct FX-HSA fusion with the designed FX-HSA fusion proteins mimicking the recombinant activated factor VII (rFVIIa)-HSA or factor IX (FIX)-HSA chimeras, both strongly dependent from artificial linkers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848183060
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http://dx.doi.org/10.1016/j.thromres.2018.11.007DOI Listing
January 2019
6 Reads

Diverting Stoma for Refractory Ano-perineal Crohn's Disease, Is It Really Useful in the Anti-TNF Era? A multivariate analysis in 74 consecutive patients.

J Crohns Colitis 2018 Nov 19. Epub 2018 Nov 19.

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, (AP-HP), University Denis Diderot (Paris VII), Clichy, France.

Background & Aims: Faecal diversion (FD) can be proposed in patients with refractory anoperineal Crohn's disease (APCD). This study aimed to assess long-term results of this strategy, following the advent of the anti-TNF era.

Methods: All patients who underwent FD for refractory APCD between 2005 and 2017 were included, excluding patients with a history of ileal pouch-anal anastomosis. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjy195DOI Listing
November 2018
7 Reads

Immunophenotypic profile as predictor of prognosis in advanced ovarian carcinoma.

Hum Pathol 2018 Nov 15. Epub 2018 Nov 15.

Department of Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

Although proteomic profiles for ovarian epithelial carcinoma (OECa) have been widely investigated, no single marker or set of predictors has been clinically implemented mainly because their reliability and validity have not yet been well established. To establish immunohistochemical (IHC) panels for prognosis prediction of OECa for use in daily pathology practice, the expression patterns of 12 IHC markers, p53, HNF-1β, ARID1A, estrogen receptor-α, progesterone receptor, vimentin, PTEN, PIK3CA, WT1, left-right determination factor, β-catenin, and Ki-67, were investigated using 282 OECas. Hierarchical clustering analysis revealed seven major immunoprofile groups (IPGs I-VII) that could be used to categorize OECa tumors independent of histotypes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183043
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http://dx.doi.org/10.1016/j.humpath.2018.10.036DOI Listing
November 2018
6 Reads

Surgery in patients with congenital factor VII deficiency - a single center study.

Pol Przegl Chir 2018 May;90(5):1-5

Instytut Hematologii i Transfuzjologii w Warszawie Klinika Chirurgii Ogólnej, Onkologicznej i Metabolicznej.

Introduction: Congenital factor VII deficiency is a rare hemorrhagic disorder inherited in an autosomal recessive pattern. Surgical treatment with insufficient diathesis correction is burdened with high risk of bleeding complications. The aim of the study was evaluation of the surgical outcome in patients with congenital factor VII deficiency and assessment of the efficacy and safety of recombinant activated factor VII (rFVIIa) used for perioperative hemostatic coverage in our two schemas of substitutive therapy. Read More

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https://ppch.pl/gicid/01.3001.0012.0668
Publisher Site
http://dx.doi.org/10.5604/01.3001.0012.0668DOI Listing
May 2018
7 Reads

Nebulised recombinant activated factor VII (rFVIIa) does not attenuate the haemorrhagic effects of blast lung injury.

J R Army Med Corps 2018 Nov 12. Epub 2018 Nov 12.

CBR Division, Dstl Porton Down, Salisbury, UK.

Introduction: Primary blast lung injury causes intrapulmonary haemorrhage. A number of case reports have suggested the efficacy of recombinant activated factor VII (rFVIIa) in the treatment of diffuse alveolar haemorrhage from a range of medical causes, but its efficacy in blast lung is unknown. The aim of this study was to investigate whether nebulised rFVIIa attenuates the haemorrhagic effects of blast lung injury in an animal model. Read More

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http://jramc.bmj.com/lookup/doi/10.1136/jramc-2018-001029
Publisher Site
http://dx.doi.org/10.1136/jramc-2018-001029DOI Listing
November 2018
4 Reads