9,965 results match your criteria Factor V


Therapeutic Options in Pregnant Women with Thrombophilia Depending on the Genetic Mutations- a Prospective Study.

Curr Health Sci J 2018 Jul-Sep;44(3):288-293. Epub 2018 Jul 15.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania.

The aim is to evaluate the effects of anticoagulant therapy (Enoxaparine) compared to antiaggregant therapy (Aspirin) on pregnancy outcome depending on the mutational status of clotting factors. The study was conducted prospectively over a 2 years period and included 110 pregnant women, of whom 80 patients diagnosed with hereditary thrombophilia and 30 healthy pregnant women, representing the control group. After careful observation, we concluded a positive influence of Enoxaparine on pregnancy outcome in pregnant women homozygous carriers for factor V Leiden gene mutation and compound heterozygous for Factor V Leiden and Prothrombin G20210A gene mutation. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311225PMC
July 2018
1 Read

Individual differences of plasma proteins and factors in fresh frozen plasma from Chinese regional blood donors.

J Thromb Thrombolysis 2019 Jan 12. Epub 2019 Jan 12.

Department of Blood Transfusion, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing, China.

Currently, single fresh frozen plasma (FFP) for clinical use is derived from individual blood donors. The objective of this study is to investigate the differences in single FFP units to make related strategies for improving FFP transfusion efficacy. 120 units of single FFP were selected randomly from Chinese PLA Clinical Blood Transfusion Center in Beijing, China. Read More

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http://dx.doi.org/10.1007/s11239-018-1789-9DOI Listing
January 2019

Utility of current thrombophilia screening in young patients with stroke and TIA.

Stroke Vasc Neurol 2018 Dec 12;3(4):231-236. Epub 2018 Sep 12.

Hyper-acute Stroke Unit, University College London Hospitals NHS Foundation Trust, London, UK.

Introduction: Approximately 40% of strokes in young adults are cryptogenic. The diagnostic yield of thrombophilia screening remains controversial. We aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack (TIA). Read More

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http://dx.doi.org/10.1136/svn-2018-000169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312074PMC
December 2018

Factor V Leiden: A Case Study.

Radiol Technol 2019 Jan;90(3):294-299

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January 2019

Factor V Leiden.

Radiol Technol 2019 Jan;90(3):259-273

Factor V Leiden thrombophilia is a genetic mutation that results in hypercoagulation of the blood that presents life-threatening symptoms. This article describes the role of imaging in diagnosis and treatment of cardiovascular complications caused by factor V Leiden and summarizes the etiology, risk factors, symptoms, diagnostic measures, progression, prognosis, and treatment of the mutation. Read More

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January 2019

Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia.

Br J Haematol 2019 Jan 10. Epub 2019 Jan 10.

Department of Paediatric Haematology and Oncology, Schneider Children's Medical Centre of Israel, Petach Tivka, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. Read More

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http://dx.doi.org/10.1111/bjh.15752DOI Listing
January 2019

Factor V Deficiency with a Thrombotic Clinical Phenotype.

Semin Thromb Hemost 2019 Jan 10. Epub 2019 Jan 10.

Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, Minnesota.

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http://dx.doi.org/10.1055/s-0038-1677041DOI Listing
January 2019

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis.

Nat Commun 2019 Jan 8;10(1):83. Epub 2019 Jan 8.

Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute, Bethesda, Maryland, 20892, USA.

Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in cancer tissues and demonstrate that TOP1MT deficiency attenuates tumor growth in human and mouse models of colon and liver cancer. Due to their mitochondrial dysfunction, TOP1MT-KO cells become addicted to glycolysis, which limits synthetic building blocks and energy supply required for the proliferation of cancer cells in a nutrient-deprived tumor microenvironment. Read More

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http://www.nature.com/articles/s41467-018-07922-3
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http://dx.doi.org/10.1038/s41467-018-07922-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325124PMC
January 2019
1 Read

Duplication of inferior vena cava and coagulation mutations with left-sided iliofemoral venous thrombosis.

J Vasc Surg Cases Innov Tech 2019 Mar 31;5(1):26-30. Epub 2018 Dec 31.

Department of Vascular and Endovascular Surgery, Sir Ganga Ram Hospital, New Delhi, India.

Duplication of the inferior vena cava (IVC) with coagulation mutations in the form of factor V Leiden and mutations represents an unusual subset of patients. We are reporting a case of a 43-year-old man who presented with left iliofemoral deep venous thrombosis diagnosed on duplex ultrasound scan. At the time of catheter-directed thrombolysis with prophylactic IVC filter placement, a duplicated IVC system was observed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24684287183012
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http://dx.doi.org/10.1016/j.jvscit.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313839PMC
March 2019
2 Reads

Factor-V Leiden G1691A and prothrombin G20210A polymorphisms in Sudanese women with preeclampsia, a case -control study.

BMC Med Genet 2019 Jan 5;20(1). Epub 2019 Jan 5.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, Al-Neelain University, P.O. Box: 12702, Khartoum, Sudan.

Background: Preeclampsia can lead to adverse maternal and perinatal outcomes. There are few studies on the association of preeclampsia with thrombophilia in Africa including Sudan.

Methods: A case -controls study was conducted at Saad Abualila Hospital in Khartoum, Sudan during the period of February through November 2017. Read More

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http://dx.doi.org/10.1186/s12881-018-0737-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321713PMC
January 2019
2.083 Impact Factor

A novel variation of SERPINC1 caused deep venous thrombosis in a Chinese family: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e13999

Department of Vascular Surgery, The Second Xiangya Hospital of Central South University.

Rationale: Deep vein thrombosis (DVT) is the formation of a blood clot formed in the deep veins of the lower limbs. Known genetic factors of DVT include deficiencies of antithrombin (AT), protein C, protein S, factor V Leiden mutation, and prothrombin G20210A mutation. Here, a 5-generation Chinese family with inherited DVT was recruited for genetic analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013999DOI Listing
January 2019
2 Reads

Clinical Impact of Thrombophilia Screening in Young Adults with Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 27. Epub 2018 Dec 27.

Department of Neurology, Weill Cornell Medicine, New York, New York; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York. Electronic address:

Objective: We evaluated the ability of genetic and serological testing to diagnose clinically relevant thrombophilias in young adults with ischemic stroke.

Methods: We performed a retrospective cohort study of patients aged 18-65 years diagnosed with acute ischemic stroke at a comprehensive stroke center between 2011 and 2015 with laboratory testing for thrombophilia. The primary outcome was any positive thrombophilia screening test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183070
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.006DOI Listing
December 2018
4 Reads

Venous thrombosis following lower-leg cast immobilization and knee arthroscopy: From a population-based approach to individualized therapy.

Thromb Res 2018 Dec 10;174:62-75. Epub 2018 Dec 10.

Department of Clinical Epidemiology, Leiden University Medical Center, the Netherlands; Department of Thrombosis and Haemostasis, Leiden University Medical Center, the Netherlands.

Venous thromboembolism (VTE) is a major complication following lower-leg cast immobilization and knee arthroscopic surgery. In this review, we aimed to give a comprehensive overview of the literature on the epidemiology, prevention and prediction of VTE in these patients. First, the cumulative incidence of VTE was estimated by performing a meta-analysis in untreated patients only. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.11.030DOI Listing
December 2018

Occlusion of anion binding exosite 2 in meizothrombin explains its impaired ability to activate factor V.

J Biol Chem 2018 Dec 21. Epub 2018 Dec 21.

Pediatrics, Children's Hospital of Philadelphia & University of Pennsylvania, United States.

The proteolytic conversion of factor V to factor Va is central for amplified flux through the blood coagulation cascade. Heterodimeric factor Va is produced by cleavage at three sites in the middle of factor V by thrombin yielding an N-terminus-derived heavy chain and a C-terminus-derived light chain. Here, we show that light chain formation resulting from the C-terminal cleavage is the rate-limiting step in the formation of fully cleaved Va. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006510DOI Listing
December 2018

Testosterone Therapy, Thrombophilia, Venous Thromboembolism, and Thrombotic Events.

J Clin Med 2018 Dec 21;8(1). Epub 2018 Dec 21.

Cholesterol, Metabolism, and Thrombosis Center, Cincinnati Ohio, OH 45220, USA.

In our sequential studies of 67 and 21 patients, testosterone therapy (TT) interacted with thrombophilia⁻hypofibrinolysis, leading to venous thromboembolism (VTE). Compared to 111 VTE controls not taking TT (VTE-no TT), the 67 and 21 cases were more likely ( < 0.05 for all) to have Factor V Leiden (FVL) heterogeneity (24% and 33% vs. Read More

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http://dx.doi.org/10.3390/jcm8010011DOI Listing
December 2018
2 Reads

Perioperative Thromboelastometry for Adult Living Donor Liver Transplant Recipients with a Tendency to Hypercoagulability: A Prospective Observational Cohort Study.

Transfus Med Hemother 2018 Nov 24;45(6):404-412. Epub 2018 Aug 24.

Anesthesia Department of Liver Institute, Menoufia University, Sheeben El Kom, Egypt.

Background: Hypercoagulability can lead to serious thromboembolic events. The aim of this study was to assess the perioperative coagulation status in liver transplant recipients with a tendency to hypercoagulability.

Methods: In a prospective observational study (South African Cochrane Registry 201405000814129), 151 potential liver transplant recipients were screened for thrombophilic factors from October 2014 to June 2017, and 57 potential recipients fulfilled the inclusion criterion of presenting two or more of the following thrombophilic factors: low protein C, low protein S, low anti-thrombin, increased homocystein, increased antiphospholipid IgG/IgM antibodies, increased lupus anticoagulant, and positive Factor V Leiden mutation. Read More

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http://dx.doi.org/10.1159/000489605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288633PMC
November 2018

Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples.

Psychol Med 2018 Dec 19:1-9. Epub 2018 Dec 19.

Virginia Institute for Psychiatric and Behavioral Genetics,Richmond, VA,USA.

Background: Vulnerability to depression can be measured in different ways. We here examine how genetic risk factors are inter-related for lifetime major depression (MD), self-report current depressive symptoms and the personality trait Neuroticism.

Method: We obtained data from three population-based adult twin samples (Virginia n = 4672, Australia #1 n = 3598 and Australia #2 n = 1878) to which we fitted a common factor model where risk for 'broadly defined depression' was indexed by (i) lifetime MD assessed at personal interview, (ii) depressive symptoms, and (iii) neuroticism. Read More

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https://www.cambridge.org/core/product/identifier/S003329171
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http://dx.doi.org/10.1017/S003329171800377XDOI Listing
December 2018
5 Reads

Treatment of rare factor deficiencies other than hemophilia.

Blood 2018 Dec 17. Epub 2018 Dec 17.

Universita degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

The deficiency of fibrinogen, prothrombin, factor V, VII, VIII, IX, X, XI and XIII, called rare coagulation disorders (RCDs), may result in coagulopathies leading to spontaneous or post-trauma and post-surgery hemorrhages. RCDs are characterized by a wide variety of symptoms, from mild to severe, which can vary significantly from one disease to another and from one patient to another. The most typical symptoms of all RCDs are mucosal bleedings and bleeding at the time of invasive procedures, while other life-threatening symptoms such as central nervous system bleeding and hemarthroses are mostly present only in some deficiencies (afibrinogenemia, FX and FXIII). Read More

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http://dx.doi.org/10.1182/blood-2018-06-820738DOI Listing
December 2018
1 Read

Packaging functionally important plasma proteins into the α-granules of human-induced pluripotent stem cell-derived megakaryocytes.

J Tissue Eng Regen Med 2018 Dec 17. Epub 2018 Dec 17.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin.

The contents of platelet α-granules arrive via a number of pathways; some are synthesized by megakaryocytes (MKs), for example, von Willebrand factor (VWF), whereas others are endocytosed from plasma, for example, fibrinogen (Fgn) and factor V (FV). Currently, almost all in vitro-induced pluripotent stem cell (iPSC)-derived MKs are generated under serum-free conditions, and their α-granule cargoes lack components that would normally be taken up from plasma during the course of megakaryopoiesis. How this might affect the ability of in vitro-derived platelets to contribute fully to haemostasis is not known. Read More

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http://dx.doi.org/10.1002/term.2785DOI Listing
December 2018

Magnetic beads assay based on zip nucleic acid for electrochemical detection of factor V Leiden mutation.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Pharmacy, Analytical Chemistry Department, Ege University, Bornova, Izmir 35100, Turkey; Biotechnology Department, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Izmir 35100, Turkey.

Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. Development of reliable methods for the detection of SNP is crucial in aspects of molecular diagnosis and personalized medicine. In our study, a genomagnetic assay in combination with zip nucleic acid (ZNA) for electrochemical detection of SNP related to Factor V Leiden (FV Leiden) mutation. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.12.107DOI Listing
December 2018
1 Read

Danger of false negative (exclusion) or false positive (diagnosis) for 'congenital thrombophilia' in the age of anticoagulants.

Clin Chem Lab Med 2018 Nov 29. Epub 2018 Nov 29.

Haematology, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, NSW 2145, Australia.

Background Most guidelines and experts recommend against performance of thrombophilia testing in general, and specifically against testing patients on pharmacological anticoagulants, due to substantially increased risk of false positive identification. For example, vitamin K antagonist (VKA) therapy affects protein C (PC) and protein S (PS), as well as some clotting assays (e.g. Read More

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http://dx.doi.org/10.1515/cclm-2018-1041DOI Listing
November 2018
1 Read

High incidence of co-existing factors significantly modifying the phenotype in patients with Fabry disease.

Gene 2019 Mar 20;687:280-288. Epub 2018 Nov 20.

Gazi University Faculty of Medicine, Department of Pediatric Metabolic Disorders, Ankara, Turkey; Gazi University Faculty of Medicine, Department of Pediatric Genetic Disorders, Ankara, Turkey. Electronic address:

Fabry disease results from deficiency of the lysosomal enzyme alpha-galactosidase A. The families of 11 index cases were screened by enzyme and molecular assays. Further clinical and laboratory investigations were carried out in all cases. Read More

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http://dx.doi.org/10.1016/j.gene.2018.11.054DOI Listing
March 2019
2 Reads

Thromboelastometry profiles after "in vitro" addition of a new plasma-derived factor V concentrate to whole blood from parahaemophilia patients.

Haemophilia 2018 Nov 23. Epub 2018 Nov 23.

Thrombotic and Haemorrhagic Diseases Unit, Department of Medicine-DIMED, Regional Centre for Haemophilia and Thrombophilia Centre, Padua University Hospital, Padua, Italy.

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http://dx.doi.org/10.1111/hae.13636DOI Listing
November 2018
2 Reads

Fetal stroke and cerebrovascular disease: Advances in understanding from lenticulostriate and venous imaging, alloimmune thrombocytopaenia and monochorionic twins.

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.008DOI Listing
November 2018
6 Reads

Tacrolimus Concentrations Measured in Excreted Bile in Liver Transplant Recipients: The STABILE Study.

Clin Ther 2018 Dec 19;40(12):2088-2098. Epub 2018 Nov 19.

Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Rennes, France; Faculté de Médecine, Université Rennes, Rennes, France; Department of Clinical and Biological Pharmacology and Pharmacovigilance, CHU Rennes, Rennes, France.

Purpose: Tacrolimus (TAC) is the main immunosuppressive drug in liver transplantation. Despite intensive therapeutic drug monitoring (TDM) that relies on whole blood trough concentration (TAC), patients still present with acute cellular rejection or TAC-related toxic effects with concentrations within the therapeutic range. TAC concentration in peripheral blood mononuclear cells (TAC) is considered as an efficient surrogate marker of TAC efficacy. Read More

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http://dx.doi.org/10.1016/j.clinthera.2018.10.015DOI Listing
December 2018
11 Reads

Dealing with death when studying disease or physiological marker: the stochastic system approach to causality.

Authors:
Daniel Commenges

Lifetime Data Anal 2018 Nov 17. Epub 2018 Nov 17.

INSERM, U 1219, Bordeaux University, 33076, Bordeaux, France.

The stochastic system approach to causality is applied to situations where the risk of death is not negligible. This approach grounds causality on physical laws, distinguishes system and observation and represents the system by multivariate stochastic processes. The particular role of death is highlighted, and it is shown that local influences must be defined on the random horizon of time of death. Read More

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http://link.springer.com/10.1007/s10985-018-9454-3
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http://dx.doi.org/10.1007/s10985-018-9454-3DOI Listing
November 2018
5 Reads

A high titer of acquired factor V inhibitor in a hemodialysis patient who developed arterial thrombosis.

Int J Hematol 2018 Nov 16. Epub 2018 Nov 16.

Japanese Collaborative Research Group on Autoimmune Coagulation Factor Deficiencies (JCRG supported by the Japanese Ministry of Health, Labor and Welfare), Yamagata, Japan.

An 87-year-old man with diabetes mellitus was admitted to control recurrent bleeding from hemodialysis puncture sites. He was a smoker and had been diagnosed with arteriosclerosis obliterans. His PT and APTT were markedly prolonged, and all coagulation factors were markedly decreased (factor V [FV] activity < 1%) or below the measurement threshold, with the exception of fibrinogen and factor XIII. Read More

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http://link.springer.com/10.1007/s12185-018-2561-9
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http://dx.doi.org/10.1007/s12185-018-2561-9DOI Listing
November 2018
9 Reads

Direct blood PCR: TaqMan-probe based detection of the venous thromboembolism associated mutations factor V Leiden and prothrombin c.20210G>A without DNA extraction.

Clin Chim Acta 2019 Jan 12;488:221-225. Epub 2018 Nov 12.

Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria. Electronic address:

Background: Practically, the initial step of genetic analysis is the extraction of DNA from blood or other cells, which is often time consuming and cost-intensive. We aimed at establishing a real-time PCR protocol for the detection of the venous thromboembolism associated mutations factor V Leiden (F5 c.1691G>A; p. Read More

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http://dx.doi.org/10.1016/j.cca.2018.11.016DOI Listing
January 2019
2 Reads

Comparison of Phenotypic Activated Protein C Resistance Testing With a Genetic Assay for Factor V Leiden.

Am J Clin Pathol 2018 Nov 13. Epub 2018 Nov 13.

Department of Laboratory Medicine, Division of Clinical Coagulation, University of Washington, Seattle.

Objectives: To compare the accuracy and reliability of phenotypic activated protein C resistance (aPC-R) assays with a genotypic assay for the factor V Leiden F5 p.R506Q (FVL) mutation.

Methods: Data were obtained from an electronic data warehouse for FVL testing performed at an academic institution with a large referral laboratory service. Read More

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https://academic.oup.com/ajcp/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcp/aqy142DOI Listing
November 2018
1 Read

Primary Hyperoxaluria Type 1 with Thrombophilia in Pregnancy: A Case Report.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):223-229. Epub 2018 Oct 4.

Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

Background: Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease caused by a mutation in the gene, resulting in deficiency of the alanineglyoxylate:aminotransferase enzyme. It is characterized by accumulation of oxalate in the kidneys and other organs.

Case Presentation: A Syrian woman with a history of nephrolithiasis and heterozygosity for factor V Leiden and prothrombin gene mutations presented with postpartum renal failure. Read More

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http://dx.doi.org/10.1159/000493091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206957PMC
October 2018
1 Read

Management of rare coagulation disorders in 2018.

Transfus Apher Sci 2018 Dec 30;57(6):705-712. Epub 2018 Oct 30.

Bleeding Disorders and Thrombosis Program, Cohen Children's Medical Center of New York and Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.

Rare bleeding disorders (RBDs) comprise inherited deficiencies of factors I (fibrinogen), II (prothrombin), V, VII, X, XI, and XIII as well as combined factor V + VIII and vitamin K-dependent factors. They represent 3-5% of all congenital bleeding disorders and are usually transmitted as autosomal recessive traits. These disorders often manifest during childhood and have varied clinical presentations from mucocutaneous bleeding to life-threatening symptoms such as central nervous system and gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1016/j.transci.2018.10.009DOI Listing
December 2018
1 Read

Recurrent thrombosis after carotid endarterectomy secondary to activated protein C resistance and essential thrombocytosis: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13118

Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University, Republic of Korea.

Rationale: Thrombosis is a major cause of morbidity in the perioperative period. Although many risk factors are known, activated protein C resistance is a prominent risk for thrombosis. Activated protein C resistance frequently occurs with recurrent thromboembolism. Read More

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http://dx.doi.org/10.1097/MD.0000000000013118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221756PMC
November 2018
2 Reads

A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia.

Case Rep Hematol 2018 27;2018:9098604. Epub 2018 Sep 27.

Internal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USA.

Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia. Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin. A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis. Read More

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https://www.hindawi.com/journals/crihem/2018/9098604/
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http://dx.doi.org/10.1155/2018/9098604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180927PMC
September 2018
8 Reads

Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI.

Res Pract Thromb Haemost 2018 Oct 25;2(4):751-756. Epub 2018 Sep 25.

Department of Molecular Pathogenesis National Cerebral and Cardiovascular Center Suita Japan.

Background: Protein S (PS) is an anticoagulant molecule that functions as a cofactor for activated protein C (APC) in the inactivation of activated coagulation factors Va (FVa) and VIIIa. It also serves as a cofactor for tissue factor pathway inhibitor (TFPI) in the efficient inhibition of factor Xa (FXa). The Lys-to-Glu (K196E, Tokushima) mutation in the EGF-2 domain of PS is a genetic risk factor for venous thromboembolism (VTE) in the Japanese population. Read More

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http://doi.wiley.com/10.1002/rth2.12152
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http://dx.doi.org/10.1002/rth2.12152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178719PMC
October 2018
7 Reads

The role of emicizumab, a bispecific factor IXa- and factor X-directed antibody, for the prevention of bleeding episodes in patients with hemophilia A.

Ther Adv Hematol 2018 Oct 10;9(10):319-334. Epub 2018 Oct 10.

Division of Pediatric Hematology/Oncology, Carmen and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, 3901 Beuabien St, Detroit, MI 48201, USA.

Hemophilia A, characterized by impaired or absent expression of factor VIII, has long been managed direct factor replacement. Functionally, factor VIII acts as a cofactor for factor IXa and allows activation of factor X, which, in combination with factor V, generates thrombin. Bispecific antibodies such as emicizumab are recombinant, monoclonal antibodies capable of recognizing and binding to two distinct antigenic targets simultaneously; emicizumab binds factors IXa and X, resulting in spatial approximation and activation of factor X, thereby mimicking the actions of factor VIII. Read More

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http://dx.doi.org/10.1177/2040620718799997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187429PMC
October 2018
1 Read

Multiple Heritable and Acquired Risk Factors in a Case of Recurrent Retinal Vein Occlusion.

J Assoc Physicians India 2018 Mar;66(3):76-78

Department of Thrombosis and Haemostasis, National Institute of Immunohaematology, Mumbai, Maharashtra.

A 40 year old female presented with branch retinal vein occlusion in the right eye followed by a second episode, a year later, of central retinal vein occlusion in the left eye. The patient was found to be heterozygous for factor V Leiden and factor V HR2 haplotype G5380A. She had a history of use of oral contraceptives, had reduced levels of tissue plasminogen activator, positive for lupus anticoagulant and diagnosed with hypertension post second episode of RVO. Read More

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March 2018
4 Reads

Risk factors for venous thromboembolism (VTE) recurrences in Thai patients without cancer.

Hematology 2019 Dec 18;24(1):159-165. Epub 2018 Oct 18.

a Department of Medicine, Faculty of Medicine , Chulalongkorn University and King Chulalongkorn Memorial Hospital , Bangkok 10330 , Thailand.

Introduction: Studies in Western countries show that VTE recurrent rates are lower in the presence of a transient provoking factor, older age, female sex and/or hormonal use, while thrombophilia (factor V Leiden or prothrombin mutation) has no predictive role. This study aimed to determine the incidence and risk factors of recurrent VTE in Asian patients.

Method: This is a retrospective cohort study in adult VTE patients who were diagnosed during 2004-2014, had no active cancer and followed-up for at least 1 year. Read More

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http://dx.doi.org/10.1080/10245332.2018.1535535DOI Listing
December 2019
3 Reads

The association between IUGR and maternal inherited thrombophilias: A case-control study.

Medicine (Baltimore) 2018 Oct;97(41):e12799

School of Medicine, University of Belgrade.

One of the risk factors for vascular obstetric complications, such as intrauterine growth restriction (IUGR), is inherited thrombophilias. Nevertheless, routine screening for thrombophilias is not endorsed in pregnant women due to their low prevalence and conflicting results of published studies regarding the usefulness of screening in these patients. The cause of IUGR remains unknown in almost 1 quarter of cases. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0009
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http://dx.doi.org/10.1097/MD.0000000000012799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203511PMC
October 2018
4 Reads
5.723 Impact Factor

Mechanical thromboprophylaxis would suffice after total knee arthroplasties in Asian patients?

Arch Orthop Trauma Surg 2018 Oct 8. Epub 2018 Oct 8.

The Joint Replacement Center, Ewha Womans University MokDong Hospital, Seoul, Republic of Korea.

Purpose: Our prospective study evaluated the incidence and location of deep vein thrombosis (DVT), the risk factors for PE and the natural history of DVT after TKA in patients who have received only mechanical compression device without having any chemical thromboprophylaxis or therapeutic treatment.

Methods: We studied 408 consecutive patients (691 knees) who underwent primary TKA; 283 patients had one-stage bilateral TKAs and 125 had unilateral TKAs. Coagulation assays, the full blood count and blood typing tests, and serum chemical profiles were undertaken in all patients on three separate occasions. Read More

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http://link.springer.com/10.1007/s00402-018-3045-3
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http://dx.doi.org/10.1007/s00402-018-3045-3DOI Listing
October 2018
2 Reads

Venous thromboembolism laboratory testing (factor V Leiden and factor II c.*97G>A), 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG).

Genet Med 2018 12 5;20(12):1489-1498. Epub 2018 Oct 5.

Knight Diagnostic Laboratories, Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA.

Factor V Leiden and factor II c.*97G>A (formerly referred to as prothrombin 20210G>A) are the two most common genetic variants associated with venous thromboembolism (VTE). Testing for these variants is one of the most common referrals in clinical genetics laboratories. Read More

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http://www.nature.com/articles/s41436-018-0322-z
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http://dx.doi.org/10.1038/s41436-018-0322-zDOI Listing
December 2018
2 Reads

The missing heritability of venous thrombosis: what about factor V Leiden heterogeneity?

J Thromb Haemost 2018 Nov 8;16(11):2125-2127. Epub 2018 Oct 8.

INSERM, INRA, C2VN, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1111/jth.14289DOI Listing
November 2018
1 Read

Stability of plasma proteins and factors in Chinese universal pooled plasma.

J Int Med Res 2018 Oct 8:300060518798999. Epub 2018 Oct 8.

1 Department of Blood Transfusion, Chinese PLA General Hospital, Beijing, China.

Objective This study aimed to determine the precision dose of Chinese universal pooled plasma (CUPP) developed by our laboratory, and the stability of plasma proteins and factors. Methods A total of 100 single fresh-frozen plasma (FFP) units were selected to test plasma proteins, including total protein, albumin, fibrinogen, factor V, factor VIII, antithrombin-III, and protein C. Different pooling protocols with 20, 40, 60, 80, and 100 units were used to optimize the number of pooled units. Read More

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http://dx.doi.org/10.1177/0300060518798999DOI Listing
October 2018
6 Reads

Multiplex testing for Factor II and Factor V mutations in thrombophilia: technical verification and clinical validation of the cobas® Factor II and Factor V test.

J Thromb Thrombolysis 2018 Oct 3. Epub 2018 Oct 3.

Roche Molecular Systems Inc, 4300 Hacienda Drive, Pleasanton, CA, 94588, USA.

Laboratory testing for thrombophilia is complicated but essential for diagnosis. In 2017, the cobas® Factor II and Factor V Test (cobas F2F5 test) was launched for use with the cobas z 480 analyzer. This qualitative polymerase chain reaction test enables multiplex Factor II and Factor V testing with flexible reporting and workflow efficiency. Read More

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http://link.springer.com/10.1007/s11239-018-1745-8
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http://dx.doi.org/10.1007/s11239-018-1745-8DOI Listing
October 2018
4 Reads

Pattern of Paracetamol Poisoning: Influence on Outcome and Complications.

Toxics 2018 Sep 29;6(4). Epub 2018 Sep 29.

Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, 1200 Brussels, Belgium.

Acute paracetamol poisoning due to a single overdose may be effectively treated by the early administration of N-acetylcysteine (NAC) as an antidote. The prognosis may be different in the case of intoxication due to multiple ingestions or when the antidote is started with delay. The aim of this work was to investigate the outcome of paracetamol poisoning according to the pattern of ingestion and determine the factors associated with the outcome. Read More

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http://dx.doi.org/10.3390/toxics6040058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315900PMC
September 2018
1 Read

Acquired factor V inhibitor-related severe bleeding due to unformed prothrombinase complex.

Thromb Res 2018 11 20;171:81-83. Epub 2018 Sep 20.

Nagahama Institute of Bio-Science and Technology, Shiga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2018.09.052DOI Listing
November 2018
20 Reads

Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation.

Eur J Obstet Gynecol Reprod Biol 2018 Nov 11;230:32-35. Epub 2018 Sep 11.

Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital, Oulu, Finland.

Objective: Maternal thrombophilia is a risk factor for adverse pregnancy outcomes. The aim of this study was to elucidate the controversial role of fetal and paternal thrombophilia in the development of severe placenta-mediated pregnancy complications.

Study Design: The study group comprised 126 mothers, 72 fetuses and 58 fathers. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.09.016DOI Listing
November 2018
2 Reads

Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells.

J Hepatol 2019 Jan 19;70(1):97-107. Epub 2018 Sep 19.

Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea; HY Indang Center of Regenerative Medicine and Stem Cell Research, Hanyang University, Seoul 04763, Republic of Korea. Electronic address:

Background & Aims: Currently, much effort is directed towards the development of new cell sources for clinical therapy using cell fate conversion by small molecules. Direct lineage reprogramming to a progenitor state has been reported in terminally differentiated rodent hepatocytes, yet remains a challenge in human hepatocytes.

Methods: Human hepatocytes were isolated from healthy and diseased donor livers and reprogrammed into progenitor cells by 2 small molecules, A83-01 and CHIR99021 (AC), in the presence of EGF and HGF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183238
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http://dx.doi.org/10.1016/j.jhep.2018.09.007DOI Listing
January 2019
19 Reads
11.340 Impact Factor

[Pulmonary embolism in a girl with nephrotic syndrome and factor V Leiden - case report].

Pol Merkur Lekarski 2018 Sep;45(267):114-118

Medical University of Warsaw, Poland: Department of Pediatrics and Nephrology.

Thromboembolic complications are found in 2-3% of children with nephrotic syndrome (NS); this increased risk is caused by hypovolemia, hemoconcentration, increased number and activity of platelets, hyperfibrinogenemia and loss of coagulation inhibitors. Risk is even higher in case of additional factors e.g. Read More

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September 2018
15 Reads

Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans.

Am J Physiol Regul Integr Comp Physiol 2018 Sep 19. Epub 2018 Sep 19.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, United States.

Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses are increased by passive heat stress, and exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In Aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to pre-syncope. Read More

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http://dx.doi.org/10.1152/ajpregu.00223.2018DOI Listing
September 2018
15 Reads