10,520 results match your criteria Factor V


A 40-Year-Old Man with Sarcoidosis and Factor V Leiden Thrombophilia Presenting with Deep Vein Thrombosis and Pulmonary Thromboembolism.

Am J Case Rep 2021 Jul 30;22:e932286. Epub 2021 Jul 30.

2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.

BACKGROUND The association between sarcoidosis and pulmonary embolism (PE) has been described in the literature, but little is known about the origin of hypercoagulability and hypofibrinolysis in sarcoidosis. PE is a multifactorial disease that is rarely caused by a single risk factor, and might be expected in disabling sarcoidosis. No data are available, however, about sarcoidosis being a risk factor for venous thromboembolism in factor V Leiden thrombophilia. Read More

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Combined Effect of MTHFR C677T and PAI-1 4G/5G Polymorphisms on the Risk of Venous Thromboembolism in Chinese Lung Cancer Patients.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211031291

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Venous thromboembolism (VTE) is a common and potentially fatal complication in cancer patients. Although several genetic risk factors related to thrombophilia have been identified, their contributions for the occurrence of VTE in cancer patients have conflicting results. The aim of this study was to evaluated the gene polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and plasminogen activator inhibitor-1 (PAI-1) 4G/5G in lung cancer patients, with and without VTE, and the combined effect on the risk of VTE. Read More

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Prevalence of positive factor V Leiden and prothrombin mutations in samples tested for thrombophilia in Saudi Arabia.

Am J Blood Res 2021 15;11(3):255-260. Epub 2021 Jun 15.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre (KFSH&RC) Riyadh, Saudi Arabia.

Venous thromboembolism (VTE) is a multifactorial disease that results from the interaction of both inherited and acquired risk factors. The complications of these risk factors often lead to significant morbidity and mortality. There are many inherited thrombophilia risk factors, such as factor V Leiden (FVL) and prothrombin gene mutation (PT). Read More

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Venous Thromboembolism in a Young Man With Fused Renal Ectopia.

JACC Case Rep 2020 Dec 16;2(15):2479-2483. Epub 2020 Dec 16.

Department of Cardiology, National Center for Global Health and Medicine, Tokyo, Japan.

A 19-year-old man presented with chest pain after a trans-Pacific flight. Venous thromboembolism was diagnosed and treated with catheter-directed thrombolysis. Genetic testing revealed factor V Leiden mutation. Read More

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December 2020

Recurrent Bleeding After Posthemorrhoidectomy Caused by Factor V Deficiency: A Case Report and Review of the Literature.

Ann Coloproctol 2021 Jul 27. Epub 2021 Jul 27.

Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.

Congenital factor V (FV) deficiency is a rare hemorrhagic disorder that can cause excessive bleeding during and after surgery in the affected patient. This report is the case of a patient who had FV deficiency with recurrent posthemorrhoidectomy bleeding treated with the hemostatic procedure and fresh frozen plasma (FFP) transfusions. A 45-year-old male patient had previously undergone hemorrhoidectomy for multiple hemorrhoids at a local hospital. Read More

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Synthesis of coagulation factors during long-term ex situ liver perfusion.

Artif Organs 2021 Jul 20. Epub 2021 Jul 20.

Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland.

Robust viability assessment of grafts during normothermic liver perfusion is a prerequisite for organ use. Coagulation parameters are used commonly for liver assessment in patients. However, they are not yet included in viability assessment during ex situ perfusion. Read More

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Significance of the p.Phe218Ser and p.Gly304Glu F5 Variants in Hereditary Factor V Deficiency.

Acta Haematol 2021 Jul 19:1-5. Epub 2021 Jul 19.

Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Hereditary factor V (FV) deficiency is a rare autosomal recessive bleeding disorder caused by F5 gene mutations. The objective of this study was to investigate the p.Phe218Ser and p. Read More

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Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling.

Hum Antibodies 2021 Jul 5. Epub 2021 Jul 5.

Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey.

This study aimed to investigate the association of increased C-Reactive Protein (CRP) and hypocomplementemia with risk factors for thrombosis such as Factor V Leiden (FVLP) and Prothrombin G20210A polymorphisms (PP), increased Activated Protein C Resistance (APCR) and decreased anti-thrombin III (ATIII) activity in women who have metabolic (MTHFR polymorphisms) and immunological risk factors (autoimmune antibody positivity, autoimmune disorders, and chronic inflammatory diseases). All patients (n= 197) were evaluated in terms of risk factors for thrombosis including FVLP, PP, increased APCR, and decreased ATIII activity as well as CRP and complement (C) 3 and C4 levels within a framework of preconceptional care program. Patients with high CRP levels together with hypocomplementemia were included to the study group (n= 13), while women with normal levels of CRP, C3, and C4 were accepted as controls (n= 184). Read More

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Successful Conservative Treatment of a Complicated Aortic Thrombus in a Woman with Factor V Leiden Mutation.

Eur J Case Rep Intern Med 2021 7;8(7):002641. Epub 2021 Jun 7.

Internal Medicine Department, CHR Haute Senne, Soignies, Belgium.

Thrombus in the aortic trunk is a rare complication. We report the case of a 63-year-old patient with a factor V Leiden mutation in whom an aortic arch thrombus was discovered accidentally. Conservative treatment was initiated with therapeutic anticoagulation with low-molecular-weight heparin leading to complete thrombus lysis after 3 months but associated shortly after anticoagulation initiation with a large splenic and limited renal infarctions. Read More

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Renal Phosphate Wasting Due to Tumor-Induced (Oncogenic) Osteomalacia.

Cureus 2021 Jun 7;13(6):e15507. Epub 2021 Jun 7.

Internal Medicine, St. Luke's University Health Network, Easton, USA.

Osteomalacia is a widely prevalent bone disorder that is caused by an imbalance in body calcium and phosphate. Tumor-induced osteomalacia (TIO) is a rare form of osteomalacia that is associated with mesenchymal tumors. It is caused by overproduction of fibroblast growth factor 23 (FGF-23), a hormone involved in phosphate regulation. Read More

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Arterial Thrombosis Associated with Factor V Leiden Mutation in a Child with Nephrotic Syndrome.

Indian J Nephrol 2021 Mar-Apr;31(2):187-189. Epub 2021 Feb 20.

Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.

Thromboembolism remains a common complication of nephrotic syndrome (NS) in adults and a less common complication in children. Venous thrombosis is well recognized, but arterial thrombosis occurs less frequently and is seen primarily in children. We report a case of arterial thrombosis associated with factor V Leiden (FVL) mutation in a young girl with NS. Read More

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February 2021

Predictive Ability of a Clinical-Genetic Risk Score for Venous Thromboembolism in Northern and Southern European Populations.

TH Open 2021 Jul 8;5(3):e303-e311. Epub 2021 Jul 8.

Genomic of Complex Diseases, Institut d'Investigació Sant Pau (IIB-Sant Pau), Barcelona, Spain.

Venous thromboembolism (VTE) is a complex, multifactorial problem, the development of which depends on a combination of genetic and acqfiguired risk factors. In a Spanish population, the Thrombo inCode score (or TiC score), which combines clinical and genetic risk components, was recently proven better at determining the risk of VTE than the commonly used model involving the analysis of two genetic variants associated with thrombophilia: the Factor V Leiden (F5 rs6025) and the G20210A prothrombin (F2 rs1799963). The aim of the present case-control study was to validate the VTE risk predictive capacity of the TiC score in a Northern European population (from Sweden). Read More

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Thromboelastometry assessment of hemostatic properties in various murine models with coagulopathy and the effect of factor VIII therapeutics.

J Thromb Haemost 2021 Jul 10. Epub 2021 Jul 10.

Blood Research Institute, Versiti Wisconsin, Milwaukee, Wisconsin, USA.

Background: Rotational thromboelastometry (ROTEM) has been commonly used to assess the viscoelastic properties of the blood clotting process in the clinic for patients with a hemostatic or prothrombotic disorder.

Objective: To evaluate the capability of ROTEM in assessing hemostatic properties in whole blood from various mouse models with genetic bleeding or clotting disease and the effect of factor VIII (FVIII) therapeutics in FVIII mice.

Methods: Mice with a genetic deficiency in either a coagulation factor or a platelet glycoprotein were used in this study. Read More

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Influenza B infection and Kawasaki disease in an adolescent during the COVID-19 pandemic: a case report.

Rev Bras Ter Intensiva 2021 Apr-Jun;33(2):320-324

Unidade de Terapia Intensiva Pediátrica, Hospital Municipal Vila Santa Catarina Dr. Gilson de Cássia Marques de Carvalho - São Paulo (SP), Brasil.

We report a case of Influenza B infection and Kawasaki disease in an adolescent, diagnosed during the COVID-19 pandemic. An asthmatic female adolescent presented with fever and flu-like symptoms for 7 days and was admitted with acute respiratory failure requiring mechanical ventilation. She progressed with hemodynamic instability responsive to vasoactive drugs. Read More

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Analysis of Intrinsic and Extrinsic Coagulation Pathway Factors in OCP Treated PCOS Women.

Indian J Clin Biochem 2021 Jul 17;36(3):278-287. Epub 2020 Jun 17.

Department of Clinical Biochemistry/Biochemistry, University of Kashmir, Hazratbal, Srinagar, J&K 190006 India.

Human polycystic ovary syndrome (PCOS)-a cluster of diseases displays various symptoms associated with endocrine and gynecological disorders in childbearing women. Oral contraceptive pills (OCP) being a drug of choice minimizes symptoms and complications associated with the disorder. But, the controversial data available in literature regarding use of OCPs compels us to setup a study design regarding effect of OCP treatment in PCOS subjects and the possible outcomes specifically regarding coagulation pathways. Read More

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Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients.

J Thromb Haemost 2021 Jul 5. Epub 2021 Jul 5.

Service d'Hématologie biologique, Hôpital Lariboisière, AP-HP.Nord, Université de Paris, Paris, France.

Background: Critically ill patients with coronavirus disease 2019 (COVID-19) are prone to developing macrothrombosis and microthrombosis. COVID-19 has been reported to be rarely associated with thrombotic microangiopathies. A disintegrin and metalloprotease with thrombospondin type I repeats, member 13 (ADAMTS13) severe deficiency, the hallmark of thrombotic thrombocytopenic purpura (TTP), induces the formation of platelet, unusually large von Willebrand factor (VWF) multimer microthrombi. Read More

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Prevalence of rare F5 variants in general population from Bosnia and Herzegovina.

Mol Biol Rep 2021 Jun 2;48(6):5181-5186. Epub 2021 Jul 2.

St. Catherine Specialty Hospital, Zagreb and Zabok, Croatia.

Human gene F5, encoding coagulation factor V, was previously reported to be highly polymorphic. Apart from FV Leiden, several other rare variants have been detected in clinical practice and associated with thrombotic events, especially in cases when patient's phenotype and FV Leiden genotype were not in agreement. In this study, the prevalence of 17 rare F5 variants has been studied on a sample of 130 healthy adult individuals from the general Bosnian-Herzegovinian population. Read More

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Thrombophilia, Inflammation, and Recurrent Pregnancy Loss: A Case-Based Review.

Semin Reprod Med 2021 Jul 2. Epub 2021 Jul 2.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Recurrent pregnancy loss (RPL) is defined as the loss of two or more pregnancies and is often multifactorial with the majority of miscarriages being due to aneuploidy and anatomic or physiological abnormalities. However, inherited or acquired thrombophilias have also been associated with RPL, albeit inconsistently. While inherited thrombophilias, such as factor V Leiden and prothrombin gene mutation, are relatively prevalent in women with RPL compared with the general population, a causal link has yet to be definitively established. Read More

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Thrombin generation abnormalities in commonly encountered platelet function disorders.

Int J Lab Hematol 2021 Jun 29. Epub 2021 Jun 29.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

Introduction: Studies of thrombin generation (TG) with platelet-rich plasma (PRP) and platelet-poor plasma (PPP) have provided insights on bleeding disorders. We studied TG for a cohort with commonly encountered platelet function disorders (PFD).

Methods: Participants included 40 controls and 31 with PFD due to: nonsyndromic dense granule (DG) deficiency (PFD-DGD, n = 9), RUNX1 haploinsufficiency (n = 6) and aggregation defects from other, uncharacterized causes (n = 16). Read More

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Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211021171

Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany.

Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Read More

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Right ventricular thrombus and pulmonary embolism after infliximab therapy for ulcerative colitis.

BMJ Case Rep 2021 Jun 28;14(6). Epub 2021 Jun 28.

Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.

Infliximab, an antitumour necrosis factor alpha (TNF-alpha)agent, is a cornerstone of treatment of inflammatory bowel disease with a favourable and well-tolerated side effect profile. While the majority of side effects associated with infliximab have been well established, the pathophysiology of infliximab-associated thrombosis remains controversial and poorly defined. We present a case of a young woman with ulcerative colitis who presented with a right ventricular thrombus and bilateral pulmonary emboli after initiation of infliximab and was subsequently found to have underlying factor V Leiden and prothrombin gene mutation. Read More

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Acquired Factor V Inhibitor Complicated with Immune Thrombocytopenia.

Intern Med 2021 Jun 26. Epub 2021 Jun 26.

Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.

We herein report a patient with a high bleeding tendency as a result of acquired factor V inhibitor and immune thrombocytopenia (ITP). The administration of prednisolone increased the platelet count, but a fatal bleeding event occurred before platelet levels had sufficiently increased. Factor V is stored in not only plasma but also platelets, and platelet-derived factor V might play a local hemostatic role. Read More

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F5-Atlanta: Factor V-short strikes again.

J Thromb Haemost 2021 Jul;19(7):1638-1640

Department of Biochemistry, CARIM, Maastricht University, Maastricht, the Netherlands.

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Ovarian vein thrombosis in the postnatal period.

BMJ Case Rep 2021 Jun 25;14(6). Epub 2021 Jun 25.

Obstetrics, Liverpool Women's Hospital, Liverpool, UK.

Although ovarian vein thrombosis (OVT) is classically considered a puerperal pathology, it can also occur in nonpuerperal settings such as endometritis, pelvic inflammatory disease, Crohn's disease, pelvic or gynaecological surgeries and thrombophilia. Hypercoagulation conditions such as antiphospholipid syndrome, systemic lupus erythematosus, factor V Leiden and protein C and S deficiency are all recognised risk factors. It is also a known complication during pregnancy often presenting with fever and lower abdominal pain within weeks after delivery. Read More

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Acquired factor V inhibitor presenting as life threatening bleeding after initiation of apixaban.

Haemophilia 2021 Jun 25. Epub 2021 Jun 25.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA.

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Immunophenotypic Analysis of Platelets by Flow Cytometry.

Curr Protoc 2021 Jun;1(6):e178

Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts.

Platelets are small but very abundant blood cells that play a key role in hemostasis, contributing to thrombus formation at sites of injury. The ability of platelets to perform this function, as well as functions in immunity and inflammation, is dependent on the presence of cell surface glycoproteins and changes in their quantity and conformation after platelet stimulation. In this article, we describe the characterization of platelet surface markers and platelet function using platelet-specific fluorescent probes and flow cytometry. Read More

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Biliary Obstruction After Transjugular Intrahepatic Portosystemic Shunt Placement.

ACG Case Rep J 2021 Jun 21;8(6):e00618. Epub 2021 Jun 21.

Department of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.

A 19-year-old man with noncirrhotic portal hypertension status post transjugular intrahepatic portosystemic shunt, gastric esophageal varices status post coil embolization, and thrombophilia because of Factor V Leiden heterozygosity presented with jaundice and elevated liver enzymes. His cholangiogram during endoscopic retrograde cholangiopancreatography demonstrated biliary tract obstruction at the bifurcation of the right and left hepatic ducts. With the aid of digital single-operator cholangioscopy, the patient was found to have a perforation of the common hepatic duct from the shunt. Read More

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Home parenteral nutrition a life-saving therapy in a primary intestinal lymphangiectasia patient affecting the entire GI tract - 3 year follow-up case report.

Ann Med Surg (Lond) 2021 Jul 9;67:102483. Epub 2021 Jun 9.

Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, PL, Poland.

Introduction And Importance: Primary intestinal lymphangiectasia (PIL) is a rare protein-losing gastroenteropathy of unknown etiology, characterized by impaired lymphatic vessels drainage. The pathological changes in PIL result in usually localized or diffuse dilatation of intestinal lacteals, leading to leakage of lymphatic fluid rich of proteins, lymphocytes, and immunoglobulins into the intestinal lumen. PIL may be asymptomatic or mildly symptomatic in moderate forms of the disease. Read More

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Pulmonary coagulation and fibrinolysis abnormalities that favor fibrin deposition in the lungs of mouse antibody-mediated transfusion-related acute lung injury.

Mol Med Rep 2021 Aug 24;24(2). Epub 2021 Jun 24.

Institute of Blood Transfusion, Chinese Academy of Medical Science and Peking Union Medical College, Chengdu, Sichuan 610052, P.R. China.

Transfusion‑related acute lung injury (TRALI) is a life‑threatening disease caused by blood transfusion. However, its pathogenesis is poorly understood and specific therapies are not available. Experimental and clinical studies have indicated that alveolar fibrin deposition serves a pathological role in acute lung injuries. Read More

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ptFVa ( Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C.

Arterioscler Thromb Vasc Biol 2021 Aug 24;41(8):2263-2276. Epub 2021 Jun 24.

Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, the Netherlands (M.S., K.L.C., P.H.R., M.H.A.B.).

[Figure: see text]. Read More

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