10,013 results match your criteria Factor V


Clotting factor activity in fresh frozen plasma after thawing with a new radio wave thawing device.

Transfusion 2019 Mar 18. Epub 2019 Mar 18.

Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen, Germany.

Background: Massive hemorrhage usually results in rapid need of blood products. Patients in need of fresh frozen plasma (FFP) might benefit from shorter thawing times using a novel radio wave device. So far, only one study on the prototype has been published. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15246DOI Listing

Influence of blood storage age on immune and coagulation parameters in critically ill transfused patients.

Transfusion 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

Background: Several retrospective studies have suggested that transfusion with red blood cells (RBCs) stored for longer periods is associated with increased mortality. The Age of Blood Evaluation (ABLE) study randomized subjects to receive fresh vs. standard issue RBC units and showed no difference in the primary or secondary endpoints of mortality or change in multi-organ dysfunction syndrome (MODS) score. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15250DOI Listing

Jejunal Varices Bleeding in a Patient with Extensive Portomesenteric Thrombosis Secondary to Factor V Leiden Mutation: A Management Dilemma.

Case Rep Gastrointest Med 2019 6;2019:4526472. Epub 2019 Feb 6.

Department of Gastroenterology, Hamad Medical Corporation, Doha, Qatar.

Ectopic varices are portosystemic collaterals that occur away from the gastroesophageal junction and account for 1-5% of all variceal bleeding. Its occurrence in the jejunum is rare. Most common cause of ectopic jejunal varices is portal hypertension especially in those patients who have undergone prior abdominal surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/4526472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381577PMC
February 2019

Increased Bleeding Risk in a Patient with Oral Anticoagulant Therapy and Concomitant Herbal Intake - A Case Report.

EJIFCC 2019 Mar 1;30(1):95-98. Epub 2019 Mar 1.

Division of Angiology, Department of Internal Medicine, Medical University of Graz, Austria.

We report the case of a 36-year old male, under stable rivaroxaban therapy for 18 months, who was admitted to our emergency room with sudden onset of hemoptysis. Anticoagulant therapy was given after recurrent spontaneous deep vein thrombosis (DVT) and a heterozygous Factor-V-Leiden mutation was present. There was no co-medication reported, however, the patient reported a constant intake of three liters of home-brewn ginger tea per day in the last month. Read More

View Article

Download full-text PDF

Source

Coronary artery disease associated with factor V Leiden mutation: a case report.

Turk Kardiyol Dern Ars 2019 Mar;47(2):148-152

Federal University of Rio de Janeiro, Edson Saad Heart Institute, Rio de Janeiro, RJ, Brasil.

The prevalence of coronary artery disease in young adults (<45 years of age) has been increasing steadily in recent decades. Although traditional cardiovascular risk factors can be identified in most cases, newly recognized associations are becoming progressively more relevant. The relationship between the factor V Leiden mutation and atherosclerosis has been a matter of debate due to conflicting data presented in previous studies. Read More

View Article

Download full-text PDF

Source
http://archivestsc.com/jvi.aspx?un=TKDA-39939
Publisher Site
http://dx.doi.org/10.5543/tkda.2018.39939DOI Listing
March 2019
4 Reads

Seroprevalence of Q fever among metropolitan and non-metropolitan blood donors in New South Wales and Queensland, 2014-2015.

Med J Aust 2019 Mar 8. Epub 2019 Mar 8.

National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, NSW.

Objectives: To estimate the prevalence of exposure to the causative agent of Q fever (Coxiella burnetii) and of current infections among blood donors in Australia.

Design, Setting: Cross-sectional study in metropolitan Sydney and Brisbane, and in non-metropolitan regions with high Q fever notification rates (Hunter New England in New South Wales; Toowoomba in Queensland).

Participants: Blood donors attending Red Cross collection centres during October 2014 - June 2015 who provided sera and completed a questionnaire on Q fever vaccination status, diagnosis and knowledge, and exposure history. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.5694/mja2.13004
Publisher Site
http://dx.doi.org/10.5694/mja2.13004DOI Listing
March 2019
3 Reads

A 54-Year-Old Man Presenting With Progressive Dyspnea and Interstitial Lung Abnormalities.

Chest 2019 Mar;155(3):e69-e74

Division of Pulmonary, Allergy & Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA; Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN.

Case Presentation: A 54-year-old man presented with a 6-month history of progressive dyspnea occurring at rest and with minimal exertion. His medical history was notable for hypertension, non-insulin-dependent diabetes, coronary artery disease, and factor V Leiden heterozygosity. His social history was notable for a 43-pack-year smoking history but was otherwise unremarkable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2018.07.039DOI Listing
March 2019
1 Read

Minor allele of the factor V K858R variant protects from venous thrombosis only in non-carriers of factor V Leiden mutation.

Sci Rep 2019 Mar 6;9(1):3750. Epub 2019 Mar 6.

Laboratory of Haematology, La Timone Hospital, Marseille, France.

Factor V serves an important role in the regulation of blood coagulation. The rs6025 (R534Q) and rs4524 (K858R) polymorphisms in the F5 gene, are known to influence the risk of venous thrombosis. While the rare Q534 (factor V Leiden) allele is associated with an increased risk of venous thrombosis, the minor R858 allele is associated with a lower risk of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-40172-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403374PMC
March 2019
1 Read

Mitigation of harmonics and unbalanced source voltage condition in standalone microgrid: positive sequence component and dynamic phasor based compensator with real-time approach.

Authors:
M Rane S Wagh

Heliyon 2019 Feb 5;5(2):e01178. Epub 2019 Feb 5.

Electrical Engineering Department, VJTI, Mumbai, India.

Penetration of Distributed Energy Resources (DER) is in high demand to supply power to the load where the grid is not available. Many of these sources are a single phase source used to form standalone Microgrid (MG). Single phase connectivity of these sources results in an unbalanced source voltage condition (UbSVC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2019.e01178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366151PMC
February 2019

In silico method for identification of novel copper and iron metabolism proteins in various neurodegenerative disorders.

Neurotoxicology 2019 Mar 1;73:50-57. Epub 2019 Mar 1.

Department of Biochemistry, AIIMS, Jodhpur, Rajasthan, India. Electronic address:

Copper (Cu) and Iron (Fe) has been the subject of intensive research over several decades as numerous seminal studies robustly support the involvement of Cu and Fe metabolism dyshomeostasis as a common denominator in several neurodegenerative disorders (particularly Alzheimer's disease and Parkinson's disease); however, till date, the exact "cause-effect" association has not been elucidated. Thus, there is urgent need to look for newer association/pathways of these redox active elements in different neuropathological conditions. Therefore, in this study, we have used bioinformatics based approach to identify novel Cu and Fe metabolism proteins in neurodegenerative disorders using Cytoscape software. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0161813X183048
Publisher Site
http://dx.doi.org/10.1016/j.neuro.2019.02.020DOI Listing
March 2019
5 Reads
3.379 Impact Factor

Segesterone acetate/Ethinyl estradiol 12-month contraceptive vaginal system safety evaluation.

Contraception 2019 Mar 1. Epub 2019 Mar 1.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Objectives: To evaluate safety outcomes from clinical studies of a 12-month contraceptive vaginal system (CVS) releasing an average of segesterone acetate (SA) 150 mcg and ethinyl estradiol (EE) 13 mcg daily.

Study Design: We integrated clinical safety data from nine studies in which women used the CVS for 21 consecutive days and removed it for 7days of each 28-daycycle. Four studies used the final manufactured CVS, including a one-year pharmacokinetic study, two one-year phase 3 trials, and a second-year treatment extension study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.contraception.2019.02.001DOI Listing
March 2019
3 Reads

Effect of Genetic Factors on the Etiopathogenesis of Thrombosed Hemorrhoidal Disease.

Chirurgia (Bucur) 2019 Jan-Feb;114(1):89-94

Objective: The aim of this study is to investigate whether genetic factors known to increase thrombosis risk play a role in the etiopathogenesis of thrombosed hemorrhoidal disease. Genomic DNA from patients with thrombosed hemorrhoidal disease was analyzed for the presence of factor V Leiden, prothrombin G20210A, methylenetetrahydrofolate reductase C677T, and methylenetetrahydrofolate reductase A1298C mutations. No significant differences were found in the allele frequencies of factor V Leiden, prothrombin G20210A, methylenetetrahydrofolate reductase C677T, and methylenetetrahydrofolate reductase A1298C mutations between patients with thrombosed hemorrhoidal disease and controls (p 0. Read More

View Article

Download full-text PDF

Source
http://www.revistachirurgia.ro/pdfs/2019-1-89.pdf
Publisher Site
http://dx.doi.org/10.21614/chirurgia.114.1.89DOI Listing
February 2019
5 Reads

Successful management of transcatheter aortic valve implantation by platelet transfusions in a nonagenarian patient with severe autoimmune factor V deficiency.

Ann Hematol 2019 Mar 4. Epub 2019 Mar 4.

Centre de Référence des Pathologies Plaquettaires Constitutionnelles, Hôpital cardiologique, Centre Hospitalo-Universitaire de Bordeaux, Pessac, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-019-03646-6DOI Listing

Stillbirth and factor V Leiden - A regional based prospective evaluation.

Thromb Res 2019 Feb 21;176:120-124. Epub 2019 Feb 21.

Sodersjukhuset, Stockholm, Sweden; Clinical Sciences and Education, Sodersjukhuset, Stockholm, Sweden. Electronic address:

Background: Approximately 10% of Swedes are carriers of coagulation factor V Leiden (FVL). It has been suggested that carriers are at an increased risk of stillbirth. We aimed to assess the risk of stillbirth in carriers of FVL as compared to non-carriers. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00493848193006
Publisher Site
http://dx.doi.org/10.1016/j.thromres.2019.02.023DOI Listing
February 2019
4 Reads

Glanzmann Thrombasthenia in a Newborn with Heterozygous Factor V Leiden and Heterozygous MTHFR C677T Gene Mutations.

Indian Pediatr 2019 Feb;56(2):143-144

Department of Pediatric Hematology and Oncology, Necmettin Erbakan University Meram Medical Faculthy, Konya, Turkey.

Introduction: Glanzmann thrombasthenia is a rare congenital platelet dysfunction.

Case Characteristics: A 2-day-old male neonate delivered at 35 weeks' gestation was referred with extensive bruising and jaundice. His elder sibling had Glanzmann thrombasthenia, and his mother had thrombophilic risk factors. Read More

View Article

Download full-text PDF

Source
February 2019
6 Reads

Ischemic colitis due to antiphospholipid antibody syndrome.

Turk J Emerg Med 2019 Jan 9;19(1):36-38. Epub 2018 Oct 9.

Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Portal system ischemia may present insidiously which may aggravates the prognosis.

Case Presentation: A 26-year old man presented with watery diarrhea and generalized abdominal pain for 3 months. On physical examination, moderate splenomegaly was noticeable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tjem.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370907PMC
January 2019
1 Read

Homozygous Factor V Leiden Thrombophilia in a Patient With Histologically Confirmed Thromboangiitis Obliterans.

Clin Med Insights Case Rep 2019 7;12:1179547619828719. Epub 2019 Feb 7.

Reconstructive Surgery and Regenerative Medicine Research Group, Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, UK.

Thromboangiitis obliterans (TAO) is a vasculitis characterised by segmental occlusions of small to medium-sized arteries and superficial veins, and a curious predilection for young male smokers. The exact aetiology remains unknown. Current theories postulate it is an autoimmune endarteritis, triggered by some constituent of tobacco and occurring in genetically susceptible individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179547619828719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376526PMC
February 2019
1 Read

Understanding the Impact of Aberrant Splicing in Coagulation Factor V Deficiency.

Int J Mol Sci 2019 Feb 20;20(4). Epub 2019 Feb 20.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy.

Rare inherited coagulation disorders (RICDs) are congenital deficiencies of the plasma proteins that are involved in blood coagulation, which generally lead to lifelong bleeding manifestations. These diseases are generally qualitative and/or quantitative defects that are associated with monoallelic or biallelic mutations in the relevant gene. Among RICDs, factor V (FV) deficiency is one of the least characterized at the molecular level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20040910DOI Listing
February 2019
1 Read

Acquired Factor V Inhibitor with Symptoms and Titer of Inhibitor Differences: Report of Two Cases.

Acta Haematol 2019 Feb 15;141(3):148-150. Epub 2019 Feb 15.

Clinical Laboratory Center, The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496080DOI Listing
February 2019
1 Read

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran.

Medicina (Kaunas) 2019 Feb 13;55(2). Epub 2019 Feb 13.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.

Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of as well as genes on ischemic stroke. In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for C677T, , and , , and prothrombin polymorphisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020047DOI Listing
February 2019
1 Read

High detection rates of antithrombin deficiency and antiphospholipid syndrome in outpatients aged over 50 years using the standardized protocol for thrombophilia screening.

Thromb Res 2019 Feb 11;176:67-73. Epub 2019 Feb 11.

Krakow Center for Medical Research and Technology, John Paul II Hospital, Krakow, Poland; Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland. Electronic address:

Introduction: Thrombophilia screening has limited detection efficiency. We assessed the detection rate when a standardized approach to thrombophilia-screened outpatients was used.

Methods: We analyzed 1185 patients (36. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2019.02.008DOI Listing
February 2019
2 Reads

Effect of pharmacological preconditioning with sevoflurane during hepatectomy with intermittent portal triad clamping.

HPB (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Anesthésie-Réanimation, Hôpital Huriez CHRU Lille, France.

Background: During hepatectomy, intermittent portal triad clamping (IPC) reduces ischemia-reperfusion injuries. Pharmacological preconditioning with sevoflurane revealed similar properties. The aim of the study was to evaluate the combination of a sevoflurane preconditioning regimen with IPC on ischemia-reperfusion injuries. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1365182X193006
Publisher Site
http://dx.doi.org/10.1016/j.hpb.2019.01.009DOI Listing
February 2019
4 Reads

Clinical implications of different risk factor profiles in patients with mesenteric venous thrombosis and systemic venous thromboembolism: a population-based study.

J Thromb Thrombolysis 2019 Feb 12. Epub 2019 Feb 12.

Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

It is unknown whether the risk factor profile for mesenteric venous thrombosis (MVT) is different from systemic venous thromboembolism (VTE). The aim of the present population-based study was to compare acquired and inherited risk factors in MVT versus VTE. Identification of all MVT patients at Skåne University Hospital between 2000 and 2015 was performed in patient records and AuriculA (Swedish anticoagulation registry). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-019-01816-xDOI Listing
February 2019
1 Read

Acquired factor V inhibitor after antibiotic treatment in a patient with pneumonia: a case report.

Ann Hematol 2019 Feb 12. Epub 2019 Feb 12.

Department of Molecular and Internal Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-019-03638-6DOI Listing
February 2019
1 Read

New functional test for the TFPIα cofactor activity of Protein S working in synergy with FV-Short.

J Thromb Haemost 2019 Feb 11. Epub 2019 Feb 11.

Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.

Essentials Protein S and FV-Short are synergistic cofactors to Tissue Factor Pathway Inhibitor α (TFPIα). An assay for the TFPIα synergistic cofactor activity of protein S with FV-Short was developed. The assay was specific for the synergistic TFPIα-cofactor activity of free protein S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.14405DOI Listing
February 2019
1 Read

Chronic Thromboembolic Pulmonary Hypertension Cases Cluster in Families.

Chest 2019 Feb;155(2):384-390

Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT.

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious sequela of pulmonary embolism (PE) and occurs in about 3% of acute PE survivors. Common inherited thrombophilias, including the Factor V Leiden mutation, are not associated with increased risk of CTEPH, even though they increase the risk for VTE. Whether other inherited genetic factors contribute to the risk of developing CTEPH remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2018.10.004DOI Listing
February 2019
1 Read

Establishment of the WHO 2nd International Standard Factor V, plasma (16/374): communication from the SSC of the ISTH.

J Thromb Haemost 2019 Feb 7. Epub 2019 Feb 7.

National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.14403DOI Listing
February 2019
2 Reads

Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A.

Cardiovasc Hematol Disord Drug Targets 2019 02 6. Epub 2019 Feb 6.

Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

Background: About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α) and FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA.

Methods: We divided 39 patients with severe HA in two groups of cases (n: 19) and control (n: 20). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871529X19666190206152315DOI Listing
February 2019
2 Reads

[Recurrence of acquired factor V inhibitor after four years of remission].

Rinsho Ketsueki 2019 ;60(1):46-50

Department of Hematology, Gunma University Graduate School of Medicine.

Acquired factor V inhibitor (AFV-I) is a rare bleeding disorder wherein autoantibodies are developed against coagulation factor V (FV). The clinical symptoms are variable, from laboratory abnormalities without bleeding to life-threatening hemorrhage. We report herein the case of a patient with AFV-I with two relapses 4 years after the first remission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11406/rinketsu.60.46DOI Listing
January 2019
1 Read

Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells.

Front Pharmacol 2019 22;10. Epub 2019 Jan 22.

Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi "G. d'Annunzio", Chieti, Italy.

Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified. We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed in obese and non-obese women for number, size, and proteomics cargo and the capacity to modulate the expression of (i) genes related to the epithelial to mesenchymal transition (EMT) and the endothelial to mesenchymal transition (EndMT), and (ii) cyclooxygenase (COX)-2 involved in the production of angiogenic and inflammatory mediators. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349702PMC
January 2019
7 Reads

SERPINC1 variants causing hereditary antithrombin deficiency in a Danish population.

Thromb Res 2019 Mar 31;175:68-75. Epub 2019 Jan 31.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

Introduction: Antithrombin deficiency is associated with increased risk of venous thromboembolism (VTE). We aimed to identify variants causing antithrombin deficiency in a Danish population.

Materials And Methods: We performed Sanger sequencing and, in relevant cases, multiplex ligation-dependent probe amplification analyses, in 46 individuals (23 index cases) with and 9 relatives without antithrombin deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2019.01.022DOI Listing
March 2019
3 Reads

Deep venous thrombosis of lower limbs in adolescents: a study in a tertiary hospital.

Int J Adolesc Med Health 2019 Feb 1. Epub 2019 Feb 1.

Unit of Adolescent Medicine, Department of Pediatrics, Hospital of Braga, Braga, Portugal.

Background Venous thromboembolism (VTE) - which includes deep venous thrombosis (DVT) and pulmonary embolism (PE) - has been increasingly recognized in the pediatric population. The estimated incidence is 0.07-0. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/ijamh.ahead-of-print/ijamh-2
Publisher Site
http://dx.doi.org/10.1515/ijamh-2018-0137DOI Listing
February 2019
11 Reads

Laboratory Diagnostics in Thrombophilia.

Hamostaseologie 2019 Feb 31;39(1):49-61. Epub 2019 Jan 31.

Department of Hematology and Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.

A thrombophilic disorder is a hereditary or acquired condition that increases the risk of thrombosis. The most common hereditary thrombophilias that predispose to venous thrombosis in the Caucasian population are the heterozygous forms of the factor V Leiden and prothrombin G20210A mutation that are generally detected by direct DNA genotyping. Immunologic antigen assays and chromogenic or clot-based activity assays are used to identify deficiencies in the natural coagulation inhibitors antithrombin, protein C and protein S. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1677840
Publisher Site
http://dx.doi.org/10.1055/s-0039-1677840DOI Listing
February 2019
13 Reads

Thrombin generation profile in non-thrombotic factor V Leiden carriers.

J Thromb Thrombolysis 2019 Jan 30. Epub 2019 Jan 30.

Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit, F 76000, Rouen, France.

Factor V Leiden (FVL) mutation is the most common genetic risk factor for venous thromboembolism. In families with a history of thrombosis, FVL can be present in 18%. Thrombin generation test is commonly used as an evaluation tool of thrombotic risk. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11239-019-01821-0
Publisher Site
http://dx.doi.org/10.1007/s11239-019-01821-0DOI Listing
January 2019
7 Reads

Livedo vasculopathy: Ablation of the affected vessels to prevent recurrent ulcerations.

Phlebology 2019 Jan 28:268355519825894. Epub 2019 Jan 28.

2 Dermatology, Phlebology and Fluid Mechanics Research Laboratory, St Vincent's Centre for Applied Medical Research (AMR), St. Vincent's Hospital, Sydney, Australia.

Background: Livedo vasculopathy is a cutaneous thrombotic microangiopathy favouring the lower legs characterised by an intense reticulate pigmentation, atrophie blanche and recurrent painful stellate ulcerations. There is a strong association with antiphospholipid syndrome, thrombophilic abnormalities, factor V Leiden mutation and more recently, lipoprotein A. Thrombotic occlusion of the dermal venules is the key pathology in livedo vasculopathyand there is no associated vasculitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0268355519825894DOI Listing
January 2019
1 Read

Tissue factor pathway inhibitor is the main determinant of thrombin generation in haemophilic patients.

Haemophilia 2019 Jan 28. Epub 2019 Jan 28.

INSERM, U1059, SAINBIOSE, Université de Lyon, UJM-Saint-Etienne, Saint-Etienne, France.

The thrombin generation (TG) assay evaluates haemostatic balance, which is influenced by the levels of many coagulation factors and inhibitors. Our objective was to identify the determinant factors of TG in haemophilia A (HA) and haemophilia B (HB) patients and to compare them to those in healthy controls. Coagulation factor and inhibitor levels, and TG, were measured in platelet-poor plasma from 40 patients with HA, 32 patients with HB and 40 healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hae.13679DOI Listing
January 2019
1 Read

Expecting the unexpected: Acquired haemophilia A in a patient with homozygous factor V deficiency.

Haemophilia 2019 Jan 28. Epub 2019 Jan 28.

Department of Haematology, Manchester Royal Infirmary, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hae.13669DOI Listing
January 2019
1 Read

Subcutaneous Inoculation of Echinococcus multilocularis Induces Delayed Regeneration after Partial Hepatectomy.

Sci Rep 2019 Jan 24;9(1):462. Epub 2019 Jan 24.

State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Alveolar echinococcosis (AE) is caused by the larval stage of echinococcus multilocularis (E. multilocularis), and hepatectomy is the main modality in hepatic AE patients. Liver regeneration after partial hepatectomy (PHx) in such patients is challenging, and further investigation is needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37293-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345980PMC
January 2019
2 Reads

A novel MAF missense mutation leads to congenital nuclear cataract by impacting the transactivation of crystallin and noncrystallin genes.

Gene 2019 Apr 17;692:113-118. Epub 2019 Jan 17.

McKusick-Zhang Center for Genetic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address:

The transcription factor v-maf avain musculoaponeurotic fibrosarcoma oncogene homolog (MAF) plays an important role in lens development. It contains a unique extended homology region (EHR) in the DNA binding domain. MAF mutations are associated with phenotypically distinct forms of congenital cataract and show different effects on the transactivation of target genes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03781119193004
Publisher Site
http://dx.doi.org/10.1016/j.gene.2019.01.011DOI Listing
April 2019
8 Reads

Polyphosphate in thrombosis, hemostasis, and inflammation.

Res Pract Thromb Haemost 2019 Jan 15;3(1):18-25. Epub 2018 Nov 15.

Department of Biological Chemistry University of Michigan Medical School Ann Arbor Michigan.

This illustrated review focuses on polyphosphate as a potent modulator of the plasma clotting cascade, with possible roles in hemostasis, thrombosis, and inflammation. Polyphosphates are highly anionic, linear polymers of inorganic phosphates that are widespread throughout biology. Infectious microorganisms accumulate polyphosphates with widely varying polymer lengths (from a few phosphates to over a thousand phosphates long), while activated human platelets secrete polyphosphate with a very narrow size distribution (about 60-100 phosphates long). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rth2.12162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332810PMC
January 2019
2 Reads

Therapeutic Options in Pregnant Women with Thrombophilia Depending on the Genetic Mutations- a Prospective Study.

Curr Health Sci J 2018 Jul-Sep;44(3):288-293. Epub 2018 Jul 15.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania.

The aim is to evaluate the effects of anticoagulant therapy (Enoxaparine) compared to antiaggregant therapy (Aspirin) on pregnancy outcome depending on the mutational status of clotting factors. The study was conducted prospectively over a 2 years period and included 110 pregnant women, of whom 80 patients diagnosed with hereditary thrombophilia and 30 healthy pregnant women, representing the control group. After careful observation, we concluded a positive influence of Enoxaparine on pregnancy outcome in pregnant women homozygous carriers for factor V Leiden gene mutation and compound heterozygous for Factor V Leiden and Prothrombin G20210A gene mutation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12865/CHSJ.44.03.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311225PMC
July 2018
6 Reads

Individual differences of plasma proteins and factors in fresh frozen plasma from Chinese regional blood donors.

J Thromb Thrombolysis 2019 Jan 12. Epub 2019 Jan 12.

Department of Blood Transfusion, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing, China.

Currently, single fresh frozen plasma (FFP) for clinical use is derived from individual blood donors. The objective of this study is to investigate the differences in single FFP units to make related strategies for improving FFP transfusion efficacy. 120 units of single FFP were selected randomly from Chinese PLA Clinical Blood Transfusion Center in Beijing, China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-018-1789-9DOI Listing
January 2019
3 Reads

Utility of current thrombophilia screening in young patients with stroke and TIA.

Stroke Vasc Neurol 2018 Dec 12;3(4):231-236. Epub 2018 Sep 12.

Hyper-acute Stroke Unit, University College London Hospitals NHS Foundation Trust, London, UK.

Introduction: Approximately 40% of strokes in young adults are cryptogenic. The diagnostic yield of thrombophilia screening remains controversial. We aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack (TIA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/svn-2018-000169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312074PMC
December 2018
1 Read

Factor V Leiden: A Case Study.

Radiol Technol 2019 Jan;90(3):294-299

View Article

Download full-text PDF

Source
January 2019

Factor V Leiden.

Radiol Technol 2019 Jan;90(3):259-273

Factor V Leiden thrombophilia is a genetic mutation that results in hypercoagulation of the blood that presents life-threatening symptoms. This article describes the role of imaging in diagnosis and treatment of cardiovascular complications caused by factor V Leiden and summarizes the etiology, risk factors, symptoms, diagnostic measures, progression, prognosis, and treatment of the mutation. Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia.

Br J Haematol 2019 Mar 10;184(6):994-998. Epub 2019 Jan 10.

Department of Paediatric Haematology and Oncology, Schneider Children's Medical Centre of Israel, Petach Tivka, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.15752DOI Listing
March 2019
2 Reads

Factor V Deficiency with a Thrombotic Clinical Phenotype.

Semin Thromb Hemost 2019 Feb 10;45(1):108-112. Epub 2019 Jan 10.

Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1677041DOI Listing
February 2019
2 Reads

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis.

Nat Commun 2019 01 8;10(1):83. Epub 2019 Jan 8.

Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NIH, National Cancer Institute, Bethesda, Maryland, 20892, USA.

Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in cancer tissues and demonstrate that TOP1MT deficiency attenuates tumor growth in human and mouse models of colon and liver cancer. Due to their mitochondrial dysfunction, TOP1MT-KO cells become addicted to glycolysis, which limits synthetic building blocks and energy supply required for the proliferation of cancer cells in a nutrient-deprived tumor microenvironment. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-07922-3
Publisher Site
http://dx.doi.org/10.1038/s41467-018-07922-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325124PMC
January 2019
1 Read