Am J Emerg Med 2022 May 10. Epub 2022 May 10.
Department of Clinical Pharmacy, Methodist University Hospital, 1265 Union Ave, Memphis, TN 38104, United States of America; University of Tennessee Health Science Center, College of Pharmacy, 881 Madison Ave, Memphis, TN 38103, United States of America.
Contamination of synthetic cannabinoids with toxic coumarin derivatives known as superwarfarins can induce a persistent coagulopathy. In comparison to warfarin, these derivatives have prolonged half-lives and laboratory assays for detection are not readily available in clinical practice. To our knowledge, factor-guided diagnosis of coagulopathy secondary to coumarin-contaminated synthetic cannabinoids has not been described previously. Read More