173,876 results match your criteria Factor II


The enhancing immune response and anti-inflammatory effects of Anemarrhena asphodeloides extract in RAW 264.7 cells.

Phytomedicine 2018 Dec 13;59:152789. Epub 2018 Dec 13.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea; Department of Korean Life Science and Technology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:

Background: Anemarrhena asphodeloides has been widely used in traditional medicine for thousands of years; it has been reported to improve learning and memory, and to reduce inflammation. However, the role of A. asphodeloides in enhancing the immune response has remained unclear. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.012DOI Listing
December 2018

Splenic Infarct After Warfarin Overdose Treatment; Is it coincidence or complication?

Authors:
Gökhan Yilmaz

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Specialist, Emergency Medicine Clinic, Kayseri Training and Research Hospital, Kayseri, Turkey. Electronic address:

The Splenic infarct is a rare clinical condition seen in the emergency department and can mimic acute abdomen. Hematologic, vascular and thromboembolic events are considered in the etiology. Treatment options are varying between symptomatic treatment and splenectomy. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.02.012DOI Listing

Association between inflammatory potential of diet and bladder cancer risk:Results from three US prospective cohort studies.

J Urol 2019 Apr 22:101097JU0000000000000279. Epub 2019 Apr 22.

Department of Epidemiology, Harvard T.H Chan School of Public Health.

Background: Inflammatory reaction has been linked to bladder cancer (BCa). Diet drives systemic inflammation and may be considered a modifiable risk factor for BCa.

Objective: To examine the association between diet with pro-inflammatory potential and BCa risk using the novel empirical dietary inflammatory pattern (EDIP) score comprised of pre-defined food groups that determine a pattern most predictive of plasma inflammatory markers. Read More

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http://dx.doi.org/10.1097/JU.0000000000000279DOI Listing

Changes in hemostasis parameters in nonfatal methicillin-sensitive Staphylococcus aureus bacteremia complicated by endocarditis or thromboembolic events: A prospective age-gender adjusted cohort study.

APMIS 2019 Apr 22. Epub 2019 Apr 22.

Division of Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Finland.

The aim was to examine changes in hemostasis parameters in endocarditis and thromboembolic events in nonfatal methicillin-sensitive Staphylococcus aureus bacteremia (MS-SAB) - a topic not evaluated previously. 155 patients were recruited and categorized according to presence of endocarditis or thromboembolic events with gender-age adjusted controls. Patients who deceased or patients not chosen as controls were excluded. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apm.12955
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http://dx.doi.org/10.1111/apm.12955DOI Listing
April 2019
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Moderate emotional reactions to stressful life events are associated with lowest risk of increased alcohol consumption: evidence from the Whitehall II study.

Eur J Public Health 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology, Claremont McKenna College, Claremont, CA, USA.

Background: Research investigating the associations between stress-related negative emotions and alcohol consumption often assumes a linear dose-response relationship. Based on the current theories of emotions, we questioned this assumption and hypothesized that both very low and very high levels of negative emotional response (NER) to stressful life events are related to increased alcohol consumption.

Methods: We used data from Phases 1 (1985-88) and 2 (1989-90) of the British Whitehall II study. Read More

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http://dx.doi.org/10.1093/eurpub/ckz066DOI Listing

Applying multivariate analysis to characterize spirits from Acoli, Uganda, by their metal contents.

Heliyon 2019 Apr 6;5(4):e01417. Epub 2019 Apr 6.

Department of Humanities and Sciences, University of California, Los Angeles, 10960 Wilshire Boulevard., Los Angeles, CA 90024, USA.

Quality control during spirits production and means of authenticating or verifying sources of spirits in the sub-Saharan region of Africa are limited due to lack of resources and the scientific acumen required to develop methodologies for characterizing spirits. However, the increasing needs to protect consumers from negligence, or willful contamination of spirits in this region underscores the urgency with which growth in this area must happen. In this paper, we describe a multivariate statistical framework upon which characterization, identification and authentication of spirits could be developed. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454205PMC

Tissue Destruction Caused by Parasite Cell Death, Inflammation, Invasion, and the Gut Microbiome.

Curr Clin Microbiol Rep 2019 21;6(1):51-57. Epub 2019 Jan 21.

1Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA USA.

Purpose Of Review: is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by

Recent Findings: Recent studies have identified new mechanisms involved in -induced tissue damage. Read More

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http://link.springer.com/10.1007/s40588-019-0113-6
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http://dx.doi.org/10.1007/s40588-019-0113-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449278PMC
January 2019
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Impact of donor age on liver regeneration and function following adult living donor liver transplantation.

Exp Ther Med 2019 May 29;17(5):3965-3970. Epub 2019 Mar 29.

Department of Radiology, Tianjin First Center Hospital, Tianjin 300192, P.R. China.

The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7454
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http://dx.doi.org/10.3892/etm.2019.7454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468505PMC
May 2019
1 Read

Micronuclei in Exfoliated Cells: A Biomarker of Genotoxicity in Tobacco Users.

Niger J Surg 2019 Jan-Jun;25(1):52-59

Private Practitioner, Dental Surgeon, Bhubaneswar, Odisha, India.

Aims: The aim of this study was to analyze the tobacco-related genotoxic effects in individual with habit of smoking and chewing tobacco.

Materials And Methods: The present study sample consisted of 120 individuals attending the outpatient department of D. J. Read More

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http://dx.doi.org/10.4103/njs.NJS_10_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452766PMC

The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription.

Nucleic Acids Res 2019 Apr 22. Epub 2019 Apr 22.

GReD laboratory, CNRS UMR6293, INSERM U1103, Faculty of Medicine, University Clermont-Auvergne, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand Cedex, France.

Specialized telomeric proteins have an essential role in maintaining genome stability through chromosome end protection and telomere length regulation. In the yeast Saccharomyces cerevisiae, the evolutionary conserved CST complex, composed of the Cdc13, Stn1 and Ten1 proteins, largely contributes to these functions. Here, we report genetic interactions between TEN1 and several genes coding for transcription regulators. Read More

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http://dx.doi.org/10.1093/nar/gkz279DOI Listing

[Use of mobile immunization teams to increase influenza vaccination coverage among heatlthcare workers. A community intervention trial].

Rev Esp Salud Publica 2019 Apr 22;93. Epub 2019 Apr 22.

Centre de Salut Ontinyent-III. Ontinyent. Valencia. España.

Objective: The use of mobile immunization teams has been proposed as a strategy to increase influenza vaccination (IV) coverage among healthcare workers (HCW), but has not been evaluated in Primary Healthcare (PHC). The objective of this work was to determine if the use of mobile immunization teams increases IV coverage among HCW of a basic health area in the Valencian Community.

Methods: Community intervention trial that included all HCWs from a basic health area in the Valencian Community. Read More

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FIGO Stage Is the Strongest Prognostic Factor in Adenocarcinoma of the Uterine Cervix.

J Obstet Gynaecol Can 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, AB; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB; Calgary Laboratory Services, Calgary, AB.

Objective: This study aimed to identify clinical and pathological determinants of invasive adenocarcinoma of the uterine cervix (AC) in a large, single-centre series serving a population of 1.5 million.

Methods: Data on clinical (n = 27) and pathological (n = 23) variables for 166 women with a diagnosis of AC treated between 2000 and 2013 were extracted from their charts and pathology reports. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.01.026DOI Listing

Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice.

Int J Hematol 2019 Apr 20. Epub 2019 Apr 20.

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.

Bleeding into the joints represents the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). In a reproducible hemarthrosis mouse model, we found distinct changes in thrombin activity in joint tissue homogenate following exposure of the joint to blood in wide type (WT) and hemophilic B mice. Specifically, at early time points (4 h and 24 h) after hemarthrosis, thrombin activity in WT mice quickly peaked at 4 h, and returned to baseline after 1 week. Read More

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http://link.springer.com/10.1007/s12185-019-02639-5
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http://dx.doi.org/10.1007/s12185-019-02639-5DOI Listing
April 2019
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In vitro assessment of edoxaban anticoagulant effect in pediatric plasma.

Thromb Res 2019 Apr 13;178:112-118. Epub 2019 Apr 13.

CHU Clermont-Ferrand, Service d'Hématologie Biologique, Clermont-Ferrand, France; Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.

Introduction: Anticoagulant therapy in pediatric patients remains an issue and safer therapies, such as direct oral anticoagulants could overcome the limitations of conventional anticoagulant treatments in this population. Edoxaban, a factor Xa inhibitor, is used for the prevention and treatment of venous thromboembolism. Due to its pharmacokinetic characteristics, edoxaban is a promising candidate molecule for children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193020
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http://dx.doi.org/10.1016/j.thromres.2019.04.014DOI Listing
April 2019
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Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity.

Trends Genet 2019 Apr 17. Epub 2019 Apr 17.

Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Universidad de Buenos Aires-CONICET, Buenos Aires 1428, Argentina; Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, Argentina. Electronic address:

The current paradigm in the field of gene regulation postulates that regulatory information for generating gene expression is organized into modules (enhancers), each containing the information for driving gene expression in a single spatiotemporal context. This modular organization is thought to facilitate the evolution of gene expression by minimizing pleiotropic effects. Here we review recent studies that provide evidence of quite the opposite: (i) enhancers can function in multiple developmental contexts, implying that enhancers can be pleiotropic, (ii) transcription factor binding sites within pleiotropic enhancers are reused in different contexts, and (iii) pleiotropy impacts the structure and evolution of enhancers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01689525193005
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http://dx.doi.org/10.1016/j.tig.2019.03.006DOI Listing
April 2019
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Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
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Telmisartan and/or Chlorogenic Acid Attenuates Fructose-Induced Non-Alcoholic Fatty Liver Disease in Rats: Implications of Cross-Talk between Angiotensin, the Sphingosine Kinase/Sphingoine-1-Phosphate Pathway, and TLR4 Receptors.

Biochem Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11459, Saudi Arabia.

Renin-angiotensin-aldosterone system (RAS) has been implicated in non-alcoholic fatty liver disease (NAFLD); the most common cause of chronic liver diseases. There is accumulating evidence that altered TLR4 and Sphingosine kinase 1(SphK1)/sphingosine1phosphate (S1P) signaling pathways are key players in the pathogenesis of NAFLD. Cross talk of the sphingosine signaling pathway, toll-4 (TLR4) receptors ,and angiotensin II was reported in various tissues. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.018DOI Listing

Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objectives: The purpose of this study was to describe sentinel lymph nodes (SLN) topography in patients with early-stage cervical cancer and to determine factors associated with atypical lymphatic drainage pathway (LDP).

Methods: We analyzed the data of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) in women undergoing surgery for early-stage cervical cancer. SLN detection was realized with a combined labeling technique (Patent blue and radioactive tracer). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193050
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http://dx.doi.org/10.1016/j.ygyno.2019.04.008DOI Listing
April 2019
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Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources (Part II): clinical, technical and socio-economic considerations.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute; Department of Hematology and Medical Oncology, University Hospital, Leipzig, Germany.

The development of hematopoietic stem cell transplantation (HSCT) programs can face significant challenges in most developing countries because such endeavors must compete with other government health care priorities, including the delivery of basic services. While this is may be a limiting factor, these countries should prioritize development of the needed expertise to offer state of the art treatments including transplantation, by providing financial, technological, legal, ethical and other needed support. This would prove beneficial in providing successful programs customized to the needs of their population, and potentially provide long-term cost-savings by circumventing the need for their citizens to seek care abroad. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.012DOI Listing

GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of T1/T17 and regulatory T cells.

FASEB J 2019 Apr 19:fj201802217RR. Epub 2019 Apr 19.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovial hyperplasia and bone and cartilage destruction. T cells, notably T helper (T)-1 and T17 cells, play a critical role in the pathologic process of RA. However, it remains unclear how T1 and T17 cells are regulated during RA. Read More

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http://dx.doi.org/10.1096/fj.201802217RRDOI Listing

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.

Autophagy 2019 Apr 19:1-17. Epub 2019 Apr 19.

a Department of Cell Biology and Biophysics, Faculty of Biology , National and Kapodistrian University of Athens , Athens , Greece.

The ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics at the whole organism level and its potential cross-talk with other proteostatic or mitostatic modules are not well understood. We show here that knock down (KD) of proteasome subunits in Drosophila flies, induced, for most subunits, developmental lethality. Read More

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http://dx.doi.org/10.1080/15548627.2019.1596477DOI Listing

Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila.

FEBS Lett 2019 Apr 18. Epub 2019 Apr 18.

Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow, 119334, Russia.

The Paip2 protein is a factor regulating mRNA translation and stability in the cytoplasm. It has also been found in the nuclei of several cell types in Drosophila. Here, we aim to elucidate the functions of Paip2 in the cell nucleus. Read More

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http://dx.doi.org/10.1002/1873-3468.13391DOI Listing

Proteases HtrA and HtrB for α-amylase secreted from Bacillus subtilis in secretion stress.

Cell Stress Chaperones 2019 Apr 18. Epub 2019 Apr 18.

State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center for Non-Food Biorefinery, Guangxi Key Laboratory of Bio-refinery, Guangxi Academy of Sciences, 98 Daling Road, Nanning, 530007, Guangxi, China.

HtrA and HtrB are two important proteases across species. In biotechnological industries, they are related to degradation of secreted heterologous proteins from bacteria, especially in the case of overproduction of α-amylases in Bacillus subtilis. Induction of HtrA and HtrB synthesis follows the overproduction of α-amylases in B. Read More

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http://link.springer.com/10.1007/s12192-019-00985-1
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http://dx.doi.org/10.1007/s12192-019-00985-1DOI Listing
April 2019
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Short-, Mid-, and Long-Term Effect of Granulocyte Colony-Stimulating Factor/Stem Cell Factor and Fms-Related Tyrosine Kinase 3 Ligand Evaluated in an In Vivo Model of Hypoxic-Hyperoxic Ischemic Neonatal Brain Injury.

Biomed Res Int 2019 13;2019:5935279. Epub 2019 Mar 13.

Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Hematopoietic growth factors are considered to bear neuroprotective potential. We have previously shown that delayed treatment with granulocyte colony-stimulating factor (G-CSF)/stem cell factor (SCF) and Fms-related tyrosine kinase 3 ligand (FL) ameliorates excitotoxic neonatal brain injury. The effect of these substances in combined-stressor neonatal brain injury models more closely mimicking clinical conditions has not been investigated. Read More

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http://dx.doi.org/10.1155/2019/5935279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436372PMC

Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.

Evid Based Complement Alternat Med 2019 14;2019:7498527. Epub 2019 Mar 14.

Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430070, China.

Objective: Simiao pill (SM), a traditional Chinese formula, has been used as an antirheumatic drug in clinical practice for hundreds of years. Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and hyperplasia, cartilage destruction, and joint damage. This study was designed to investigate the protective effects of SM on collagen-induced arthritis (CIA) in rats. Read More

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http://dx.doi.org/10.1155/2019/7498527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437962PMC

In Vitro Antiatherothrombotic Effects of Extracts from L., L., and Benth.

Evid Based Complement Alternat Med 2019 14;2019:3245836. Epub 2019 Mar 14.

Food and Science Technology Research Centre, MARDI, Serdang, Selangor, Malaysia.

Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. Read More

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https://www.hindawi.com/journals/ecam/2019/3245836/
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http://dx.doi.org/10.1155/2019/3245836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437728PMC
March 2019
2 Reads

Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys ().

Int J Endocrinol 2019 13;2019:2047803. Epub 2019 Mar 13.

Laboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, Brazil.

This study aimed at evaluating the availability of the primate as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. Read More

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http://dx.doi.org/10.1155/2019/2047803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436371PMC

Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging ST101 Lineage.

Front Microbiol 2019 2;10:542. Epub 2019 Apr 2.

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.

The global dissemination of and carbapenemase (KPC) has been largely attributed to a few high-risk sequence types (STs) (ST258, ST11, ST512) associated with human disease. ST101 is an emerging clone that has been identified in different parts of the world with the potential to become a global, persistent public health threat. Recent research suggests the ST101 lineage is associated with an 11% increase in mortality rate in comparison to non-ST101 infections. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454207PMC

Aging and Comorbidities in Acute Pancreatitis II.: A Cohort-Analysis of 1203 Prospectively Collected Cases.

Front Physiol 2018 2;9:1776. Epub 2019 Apr 2.

Institute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.

Our meta-analysis indicated that aging influences the outcomes of acute pancreatitis (AP), however, a potential role for comorbidities was implicated, as well. Here, we aimed to determine how age and comorbidities modify the outcomes in AP in a cohort-analysis of Hungarian AP cases. Data of patients diagnosed with AP by the revised Atlanta criteria were extracted from the Hungarian Registry for Pancreatic Patients. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01776
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http://dx.doi.org/10.3389/fphys.2018.01776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454835PMC
April 2019
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Aging and Comorbidities in Acute Pancreatitis I: A Meta-Analysis and Systematic Review Based on 194,702 Patients.

Front Physiol 2019 2;10:328. Epub 2019 Apr 2.

Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.

Acute pancreatitis (AP) is one of the most common cause of hospitalization among gastrointestinal diseases worldwide. Although most of the cases are mild, approximately 10-20% of patients develop a severe course of disease with higher mortality rate. Scoring systems consider age as a risk factor of mortality and severity (BISAP; >60 years, JPN>70 years, RANSON; >55 years, APACHE II >45 years). Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00328
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http://dx.doi.org/10.3389/fphys.2019.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454469PMC
April 2019
2 Reads

Application of tabu search-based Bayesian networks in exploring related factors of liver cirrhosis complicated with hepatic encephalopathy and disease identification.

Sci Rep 2019 Apr 18;9(1):6251. Epub 2019 Apr 18.

Department of Health Statistics, School of Public Health, Shanxi Medical University, No.56 XinJian South Road, Taiyuan, Shanxi, 030001, China.

This study aimed to explore the related factors and strengths of hepatic cirrhosis complicated with hepatic encephalopathy (HE) by multivariate logistic regression analysis and tabu search-based Bayesian networks (BNs), and to deduce the probability of HE in patients with cirrhosis under different conditions through BN reasoning. Multivariate logistic regression analysis indicated that electrolyte disorders, infections, poor spirits, hepatorenal syndrome, hepatic diabetes, prothrombin time, and total bilirubin are associated with HE. Inferences by BNs found that infection, electrolyte disorder and hepatorenal syndrome are closely related to HE. Read More

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http://dx.doi.org/10.1038/s41598-019-42791-wDOI Listing

Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence.

J Biol Chem 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology, University of Michigan.

Mutations in the genes encoding telomerase reverse transcriptase (TERT) and telomerase's RNA components, as well as shortened telomeres, are risk factors for idiopathic pulmonary fibrosis (IPF), wherein repetitive injury to the alveolar epithelium is considered to be a key factor in pathogenesis. Given the importance of TERT in stem cells, we hypothesized that TERT plays an important role in epithelial repair and that its deficiency results in exacerbation of fibrosis by impairing this repair/regenerative process. To evaluate the role of TERT in epithelial cells, we generated type II alveolar epithelial cell (AECII) specific TERT conditional knockout mice (SPC-Tert cKO) by crossing floxed TERT mice with inducible SPC-driven Cre mice. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006615DOI Listing

Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial.

Lancet HIV 2019 Apr 15. Epub 2019 Apr 15.

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; SEARCH, the Thai Red Cross AIDS Research Center, Bangkok, Thailand; Department of Global Health, University of Amsterdam, Amsterdam, Netherlands.

Background: HIV-1-specific broadly neutralising antibodies such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells. We investigated whether VRC01 could promote sustained viral control off antiretroviral therapy (ART) in adults who initiated ART during acute HIV infection.

Methods: We did a randomised, double-blind, placebo-controlled trial at the Thai Red Cross AIDS Research Centre in Bangkok, Thailand. Read More

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http://dx.doi.org/10.1016/S2352-3018(19)30053-0DOI Listing

Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial.

Arthritis Res Ther 2019 Apr 18;21(1):101. Epub 2019 Apr 18.

Takeda Development Centre, London, UK.

Background: Namilumab (AMG203), an immunoglobulin G1 monoclonal antibody that binds with high affinity to granulocyte-macrophage colony-stimulating factor (GM-CSF), was evaluated in a phase II randomized, double-blind, placebo-controlled study to investigate the efficacy and safety in patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX-IR) or anti-tumour necrosis factor therapy (TNF-IR).

Methods: Subcutaneous namilumab (20, 80, or 150 mg) or placebo was administered at baseline and weeks 2, 6, and 10 in patients on stable background methotrexate therapy who were with MTX-IR or TNF-IR. Primary endpoint was mean change from baseline in the 28-joint Disease Activity Score, C-reactive protein version (DAS28-CRP) at week 12 comparing each of the three doses of namilumab to placebo. Read More

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http://dx.doi.org/10.1186/s13075-019-1879-xDOI Listing

The epidemiology of aerobic physical activity and muscle-strengthening activity guideline adherence among 383,928 U.S. adults.

Int J Behav Nutr Phys Act 2019 Apr 18;16(1):34. Epub 2019 Apr 18.

Physically Active Lifestyles Research Group (USQ PALs), Centre for Health, Informatics, and Economics Research, Institute for Resilient Regions, University of Southern Queensland, Education City, Springfield Central, Brisbane, QLD, 4300, Australia.

Background: The World Health Organization's 'Global Recommendations on Physical Activity for Health' state that adults should engage in regular moderate-to-vigorous intensity aerobic physical activity (MVPA; e.g. walking, running, cycling) and muscle-strengthening activity (MSA; e. Read More

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http://dx.doi.org/10.1186/s12966-019-0797-2DOI Listing

Glucose screening within six months postpartum among Chinese mothers with a history of gestational diabetes mellitus: a prospective cohort study.

BMC Pregnancy Childbirth 2019 Apr 18;19(1):134. Epub 2019 Apr 18.

Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.

Background: Gestational diabetes mellitus (GDM) is a risk factor for diabetes mellitus. The 75-g, 2-h oral glucose tolerance test is recommended for mothers with a history of GDM to screen for diabetes in the postnatal period. The aim of this study was to investigate the rate of glucose screening within 6 months postpartum among Chinese mothers with a history of GDM, and to identify its predictors. Read More

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http://dx.doi.org/10.1186/s12884-019-2276-9DOI Listing

Identification of evolutionarily conserved downstream core promoter elements required for the transcriptional regulation of Fushi tarazu target genes.

PLoS One 2019 18;14(4):e0215695. Epub 2019 Apr 18.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.

The regulation of transcription initiation is critical for developmental and cellular processes. RNA polymerase II (Pol II) is recruited by the basal transcription machinery to the core promoter where Pol II initiates transcription. The core promoter encompasses the region from -40 to +40 bp relative to the +1 transcription start site (TSS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215695PLOS

FLT3 inhibitor quizartinib (AC220).

Leuk Lymphoma 2019 Apr 18:1-11. Epub 2019 Apr 18.

a Department of Leukemia , University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Acute myeloid leukemia (AML) is a heterogeneous disease and remains a therapeutic challenge. Cytogenetics is a well-established prognostic factor. Recent discovery of molecular mutations has gained momentum with some being potential therapeutic targets. Read More

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http://dx.doi.org/10.1080/10428194.2019.1602263DOI Listing
April 2019
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Prognostic Relevance of Tertiary Lymphoid Organs Following Neoadjuvant Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma.

Cancer Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Gastroenterological Surgery II, Hokkaido University, Faculty of Medicine.

The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLOs) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. Read More

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http://dx.doi.org/10.1111/cas.14023DOI Listing

Comparative analysis of microleakage of temporary filling materials used for multivisit endodontic treatment sessions in primary teeth: an in vitro study.

Eur Arch Paediatr Dent 2019 Apr 17. Epub 2019 Apr 17.

Department of Pediatric and Preventive dentistry, Vokkaligara Sangha Dental College and Hospital, Bangalore, Karnataka, 560004, India.

Purpose: Coronal leakage is an important factor contributing to the failure of endodontic treatment. The use of an efficient temporary restoration between sessions of multiple-visit pulpectomies is irrefutable. Two cements have long been used in endodontics-IRM, which is a reinforced zinc oxide cement and Cavit G, a calcium sulphate based cement. Read More

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http://dx.doi.org/10.1007/s40368-019-00436-6DOI Listing

Transcriptional silencing of centromere repeats by heterochromatin safeguards chromosome integrity.

Curr Genet 2019 Apr 17. Epub 2019 Apr 17.

Department of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.

The centromere region of chromosomes consists of repetitive DNA sequences, and is, therefore, one of the fragile sites of chromosomes in many eukaryotes. In the core region, the histone H3 variant CENP-A forms centromere-specific nucleosomes that are required for kinetochore formation. In the pericentromeric region, histone H3 is methylated at lysine 9 (H3K9) and heterochromatin is formed. Read More

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http://dx.doi.org/10.1007/s00294-019-00975-xDOI Listing

Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies.

Kidney Int Rep 2019 Apr 21;4(4):541-550. Epub 2018 Dec 21.

Department of Pediatrics, Division of Pediatric Nephrology, Duke University, Durham, North Carolina, USA.

Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non-human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies (DSAs). Our aim was to examine serum cytokine profiles associated with AT1R-Ab and distinguish them from those associated with HLA DSA in serially collected blood samples from a cohort of pediatric renal transplant recipients.

Methods: Blood samples from 65 pediatric renal transplant recipients drawn during the first 3 months posttransplant, at 6, 12, and 24 months posttransplant, and during suspected episodes of kidney transplant rejection were tested for AT1R-Ab, HLA DSA, and a panel of 6 cytokines (tumor necrosis factor [TNF]-α, interferon [IFN]-γ, interleukin [IL]-8, IL-1β, IL-6, and IL-17). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183035
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http://dx.doi.org/10.1016/j.ekir.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451195PMC
April 2019
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Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in .

PeerJ 2019 12;7:e6718. Epub 2019 Apr 12.

Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.

The anthrax toxin is a virulence factor produced by the bacterium . Transcription of anthrax toxin genes is controlled by the transcription factor AtxA. Thus, AtxA is thought to be a key factor for the pathogenicity of . Read More

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https://peerj.com/articles/6718
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http://dx.doi.org/10.7717/peerj.6718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463858PMC
April 2019
2 Reads

A rational quest for selectivity through precise ligand-positioning in tandem DNA-catalysed Friedel-Crafts alkylation/asymmetric protonation.

Chem Sci 2019 Mar 24;10(10):2875-2881. Epub 2019 Jan 24.

Institut des Biomolécules Max Mousseron , CNRS , Université de Montpellier , ENSCM , Place Eugène Bataillon , 34095 Montpellier , France . Email:

Covalent anchorage of a metallic co-factor to a DNA-based architecture is merely the only way to ensure an accurate positioning of a catalytic site within the chiral micro-environment offered by the DNA double helix. Ultimately, it also allows a fine-tuning of the catalytic pocket through simple synthetic modifications of the DNA sequence. Here, we report highly selective copper(ii)-catalysed asymmetric Friedel-Crafts conjugate addition/enantioselective protonation, which is due to a careful positioning of a bipyridine ligand within a DNA framework. Read More

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http://dx.doi.org/10.1039/c8sc05543bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429601PMC

Cooperativity basis for small-molecule stabilization of protein-protein interactions.

Chem Sci 2019 Mar 25;10(10):2869-2874. Epub 2019 Jan 25.

Laboratory of Chemical Biology , Department of Biomedical Engineering and Institute for Complex Molecular Systems , Eindhoven University of Technology , P. O. Box 513 , 5600MB , Eindhoven , The Netherlands . Email:

A cooperativity framework to describe and interpret small-molecule stabilization of protein-protein interactions (PPI) is presented. The stabilization of PPIs is a versatile and emerging therapeutic strategy to target specific combinations of protein partners within the protein interactome. Currently, the potency of PPI stabilizers is typically expressed by their apparent affinity or EC. Read More

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http://xlink.rsc.org/?DOI=C8SC05242E
Publisher Site
http://dx.doi.org/10.1039/c8sc05242eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429609PMC
March 2019
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Prognostic implications of epidermal growth factor receptor variant III expression and nuclear translocation in Chinese human gliomas.

Chin J Cancer Res 2019 Feb;31(1):188-202

Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant III (EGFRvIII) expression and EGFRvIII nuclear translocation in Chinese human gliomas.

Methods: We retrospectively examined EGFRvIII expression and EGFRvIII nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization (WHO) II gliomas, 84 WHO III gliomas and 72 glioblastomas (WHO IV). Factors that correlated with EGFRvIII and EGFRvIII nuclear translocation expression were analyzed by the Chi-square test. Read More

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http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433583PMC
February 2019
1 Read

[Comprehensive treatment of adrenal cortical carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

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April 2019
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Restoration of FVIII expression by targeted gene insertion in the FVIII locus in hemophilia A patient-derived iPSCs.

Exp Mol Med 2019 Apr 17;51(4):45. Epub 2019 Apr 17.

Department of Physiology, Yonsei University College of Medicine, 50-1 Yonsei-ro Seodaemun-gu, Seoul, 03722, Korea.

Target-specific genome editing, using engineered nucleases zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and type II clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), is considered a promising approach to correct disease-causing mutations in various human diseases. In particular, hemophilia A can be considered an ideal target for gene modification via engineered nucleases because it is a monogenic disease caused by a mutation in coagulation factor VIII (FVIII), and a mild restoration of FVIII levels in plasma can prevent disease symptoms in patients with severe hemophilia A. In this study, we describe a universal genome correction strategy to restore FVIII expression in induced pluripotent stem cells (iPSCs) derived from a patient with hemophilia A by the human elongation factor 1 alpha (EF1α)-mediated normal FVIII gene expression in the FVIII locus of the patient. Read More

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http://dx.doi.org/10.1038/s12276-019-0243-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470126PMC
April 2019
1 Read
3.446 Impact Factor

Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice.

Sci Rep 2019 Apr 17;9(1):6201. Epub 2019 Apr 17.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

The underlying pathogenesis of chronic kidney disease involves an activated renin-angiotensin system and systemic inflammation which ultimately develop renal injury. Rikkunshito (RKT) has been reported to exert anti-fibrotic and anti-inflammatory effects through enhancement of ghrelin signaling pathway. In this study, we investigated the effects of RKT on renal fibrosis and inflammation in angiotensin II (Ang II)-induced renal injury model. Read More

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http://www.nature.com/articles/s41598-019-42657-1
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http://dx.doi.org/10.1038/s41598-019-42657-1DOI Listing
April 2019
3 Reads

Remnant Lipoproteins Are Residual Risk Factor for Future Cardiovascular Events in Patients With Stable Coronary Artery Disease and On-Statin Low-Density Lipoprotein Cholesterol Levels <70 mg/dL.

Circ J 2019 Apr 18. Epub 2019 Apr 18.

Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine.

Background: This study examined the predictive value of remnant lipoprotein levels for cardiovascular events (CVEs) in patients with stable coronary artery disease (CAD) and low-density lipoprotein cholesterol (LDL-C) levels <70 mg/dL on statin treatment.Methods and Results:Serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol: RLP-C) were measured by an immunoseparation method in 247 consecutive patients with CAD who had on-statin LDL-C levels <70 mg/dL. All the patients were followed prospectively for a period of ≤60 months or until the occurrence of the primary composite endpoint of cardiac death, nonfatal myocardial infarction, unstable angina requiring coronary revascularization, worsening heart failure, peripheral artery disease, aortic event, and ischemic stroke. Read More

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http://dx.doi.org/10.1253/circj.CJ-19-0047DOI Listing
April 2019
1 Read