199,503 results match your criteria Factor II

Cabbage (Brassica oleracea) mitigates lead (II) acetate-induced testicular dysfunction in Wistar rats via up-regulation of Bcl-2 protein expression, pituitary-testicular hormonal axis and down-regulation of oxido-inflammatory reactions.

Andrologia 2022 May 21:e14476. Epub 2022 May 21.

Department of Physiology, University of Port-Harcourt, Port-Harcourt, Nigeria.

Oxido-inflammatory stress has been involved in lead-induced testicular dysfunction and plants rich in anti-oxidants has been reported to be beneficial in combating heavy metal poisonings in animal studies. However, cabbage juice protective effect on lead-induced testicular dysfunction was investigated in this study. Twenty male Wistar rats were selected into four (n = 5) groups and given distilled water (1 ml/100 g body weight), lead acetate (25 mg/kg body weight), cabbage juice (1 ml/100 g body weight), and lead acetate with cabbage juice, respectively. Read More

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Effect of exercise and curcumin on cardiomyocyte molecular mediators associated with oxidative stress and autophagy in aged male rats.

Microvasc Res 2022 May 18:104380. Epub 2022 May 18.

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Aim: Aging can origin changes in the heart that may increase risk of developing cardiovascular disease. This study aimed to characterize autophagy alterations and related molecular mediators in the heart tissue in the aging alone or in combination with exercise and curcumin treatment.

Methods: Seven young and twenty-eight elderly male Wistar rats were assigned into five groups, namely: young control, age, exercise, curcumin, and curcumin+exercise. Read More

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Neoadjuvant and Adjuvant Systemic Therapy for Early-Stage Non-small-Cell Lung Cancer.

Drugs 2022 May 21. Epub 2022 May 21.

Division of Medical Oncology, Duke Cancer Institute, Duke University Medical Center, DUMC 3841, Durham, NC, 27710, USA.

Approximately a third of patients with non-small-cell lung cancer (NSCLC) present with surgically resectable disease. Patients who undergo surgical resection are at a high risk of relapse, and neoadjuvant and adjuvant chemotherapy improves disease-free survival (DFS) and overall survival (OS). The outcomes with neoadjuvant and adjuvant chemotherapy are similar, and both are used in clinical practice. Read More

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Role of LL-37 in thrombotic complications in patients with COVID-19.

Cell Mol Life Sci 2022 May 21;79(6):309. Epub 2022 May 21.

Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.

Blood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and a high-risk factor for severe illness and death. Neutrophil extracellular traps (NETs) are implicated in COVID-19-induced immunothrombosis. Furthermore, human cathelicidin, a NET component, can perturb the interaction between the SARS-CoV-2 spike protein and its ACE2 receptor, which mediates viral entry into cells. Read More

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Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies.

J Neurol 2022 May 20. Epub 2022 May 20.

Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Lyon 1 University, Lyon, France.

Objective: To characterize the evolution of epilepsy in patients with leucine-rich glioma inactivated 1 antibody-associated (LGI1ab) limbic encephalitis, including factors associated with drug-resistant epilepsy (DRE).

Methods: Retrospective analysis of patients with LGI1 encephalitis managed at two tertiary epilepsy centers between 2005 and 2019 and whose samples were confirmed by the French Reference Center of Paraneoplastic Neurological Syndromes. Raw clinical, biological, EEG, and MRI data were reviewed. Read More

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A print-and-fuse Strategy for Sacrificial Filaments Enables Biomimetically Structured Perfusable Microvascular Networks with Functional Endothelium Inside 3D Hydrogels.

Adv Mater 2022 May 20:e2200653. Epub 2022 May 20.

Chair for Functional Materials for Medicine and Dentistry at the Institute for Functional Materials and Biofabrication (IFB) and Bavarian Polymer Institute (BPI), University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Current methods of microvessel fabrication mostly rely on self-assembly in tiny volumes, prefabricated designs of microchannels, or demand complicated multi-step procedures based on sacrificial templating to achieve specific geometrical features. Such application-oriented geometries subsequently require a design-specific and functional perfusion system that must be developed in parallel. In this study, we present a facile and flexible approach for the integration of biomimetically branched microvasculature within bulk hydrogels. Read More

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Flow-based determination of lead exploiting in-syringe dispersive liquid-liquid micro-extraction in xylene and integrated spectrophotometric detection.

Talanta 2022 May 10;247:123528. Epub 2022 May 10.

Sciware Systems, S.L. 07193, Bunyola, Spain. Electronic address:

A lab-in-syringe flow system exploiting dispersive liquid-liquid micro-extraction in a solvent lighter than water is proposed for the spectrophotometric determination of lead in industrial residual waters. The steps inherent to both liquid-liquid extraction and monitoring of the formed compound are in-syringe carried out. The classical carbon tetrachloride is not used as the extracting solvent, as it does not present the friendly characteristics inherent to the Green Analytical Chemistry. Read More

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Plumbagin ameliorates bile duct ligation-induced cholestatic liver injury in rats.

Biomed Pharmacother 2022 May 17;151:113133. Epub 2022 May 17.

Department of Veterinary Medicine, National Chung Hsing University, Taichung City 402, Taiwan. Electronic address:

Plumbagin, a natural bicyclic naphthoquinone, has diverse pharmacological properties and biological benefits against a number of disorders, including liver disease. Though plumbagin's hepatoprotective potential attracts attention, currently no experimental evidence exists on its effectiveness against cholestatic liver injury. The present study investigated its hepatoprotection in the rat model of extrahepatic cholestasis using Bile Duct Ligation (BDL). Read More

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Outcome of breast cancer patients treated with chemotherapy during pregnancy compared with non-pregnant controls.

Eur J Cancer 2022 May 17;170:54-63. Epub 2022 May 17.

German Breast Group, Neu-Isenburg, Germany.

Background: A diagnosis of breast cancer during pregnancy (PrBC) does not impact prognosis if standard treatment is offered. However, caution is warranted as gestational changes in pharmacokinetics may lead to reduced chemotherapy concentration.

Methods: Survival of PrBC patients treated with chemotherapy during pregnancy was compared to non-pregnant breast cancer patients treated with chemotherapy, diagnosed after 2000, excluding patients older than 45 years or with a postpartum diagnosis. Read More

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Recipes for superior ionic conductivities in thin-film ceria-based electrolytes.

Phys Chem Chem Phys 2022 May 20. Epub 2022 May 20.

Institute of Physical Chemistry, Landoltweg 2, RWTH Aachen University, 52056 Aachen, Germany.

We employed Molecular Dynamics (MD) and Metropolis Monte Carlo (MMC) simulations to determine the oxide-ion mobility in CeGdO ( = 0.02, 0.1, 0. Read More

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Major adverse cardiovascular events in bulgarian patients with chronic coronary syndrome.

Niger J Clin Pract 2022 May;25(5):710-717

Department of Cardiology, Medical University, University Hospital Alexandrovska, Clinic of Propedeutics of Internal Diseases, Sofia, Bulgaria.

Background: In primary prevention, most guidelines rely on atherosclerotic cardiovascular disease risk assessment to determine the appropriateness and intensity of risk factor modification.

Aims: This study aimed to analyze the prognostic role of risk factors, comorbidities, and coronary artery calcium score (CACS) for major adverse cardiovascular events (MACEs) in Bulgarian patients with chronic coronary syndrome. An observational study conducted in a cardiology department. Read More

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A retrospective study of factors contributing to anchorage loss in upper premolar extraction cases.

Niger J Clin Pract 2022 May;25(5):664-669

Department of Orthodontics, Peking University School and Hospital of Stomatology; National Center of Stomatology and National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing, China.

Background: Anchorage control is one of the components in the treatment of extraction cases. However, what determines more or less anchorage loss is still an unanswered question. Aim: The purpose of this study was to investigate the most important factors contributing to the anchorage loss of maxillary first molars in premolar extraction cases. Read More

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Clinical characteristics and long-term outcome of cerebral cavernous malformations-related epilepsy.

Epilepsia 2022 May 20. Epub 2022 May 20.

Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Objective: Cerebral cavernous malformations (CCMs) present variably and epileptic seizures are the most common symptom. The factors contributing to cavernoma-related epilepsy (CRE) and drug resistance remain inconclusive. The outcomes of CRE after different treatment modalities have not yet been fully addressed. Read More

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Genetic Variations of Modulate Glioma Susceptibility and Prognosis in a Chinese Han Population.

Pharmgenomics Pers Med 2022 11;15:487-497. Epub 2022 May 11.

Department of Neurosurgery, Xi'an Children's Hospital, Xi'an, 710043, People's Republic of China.

Background: This study aimed to evaluate the relationship between polymorphisms and glioma risk and prognosis in a Chinese Han population.

Methods: Seven single nucleotide polymorphisms (SNPs) in were genotyped among 592 glioma patients and 502 healthy controls. Log-additive models were used for risk assessment by the odds ratios (ORs) and 95% confidence intervals (CIs). Read More

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Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study.

Front Psychiatry 2022 3;13:813256. Epub 2022 May 3.

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Objective: The potential role of sub-optimal pharmacological treatment in the poorer outcomes observed in bipolar disorder (BD) with vs. without comorbid substance use disorders (SUDs) is not known. Thus, we investigated whether patients with BD and comorbid SUD had different medication regimens than those with BD alone, in samples from France and Norway, focusing on compliance to international guidelines. Read More

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Efficacy of Xuebijing Combined with Ulinastatin in the Treatment of Traumatic Sepsis and Effects on Inflammatory Factors and Immune Function in Patients.

Front Surg 2022 3;9:899753. Epub 2022 May 3.

Department of Emergency Medicine, Chongqing Qijiang District People's Hospital, Chongqing, China.

Objective: To investigate the efficacy of xuebijing combined with ulinastatin in the treatment of traumatic sepsis and analyze the effects on inflammatory factors and immune function of patients.

Methods: 182 patients with traumatic sepsis were selected from June 2017 to September 2021 in our hospital. The patients were divided into the control group and the observation group. Read More

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Diagnostic criteria for acute-on-chronic liver failure and related disease conditions in Japan.

Hepatol Res 2022 May;52(5):417-421

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

The Intractable Hepato-Biliary Disease Study Group of Japan, sponsored by the Ministry of Health, Labor and Wealth, proposed in 2018 that patients with cirrhosis and a Child-Pugh score of 5-9 should be diagnosed as having acute-on-chronic liver failure (ACLF) when a deterioration of liver function ("serum bilirubin level of 5.0 mg/dl or more" and "prothrombin time value of 40% or less of the standardized values and/or international normalization rates of 1.5 or more") caused by severe liver damage develops within 28 days after an acute insult, including alcohol abuse, bacterial infection, gastrointestinal bleeding, and the exacerbation of underlying liver diseases. Read More

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Estimating CO Emissions from IoT Traffic Flow Sensors and Reconstruction.

Sensors (Basel) 2022 Apr 28;22(9). Epub 2022 Apr 28.

DISIT Lab, Department of Information Engineering, University of Florence, 50139 Firenze, Italy.

CO emissions from burning fossil fuels make a relevant contribution to atmospheric changes and climate disruptions. In cities, the contribution by traffic of CO is very relevant, and the general CO estimation can be computed (i) on the basis of the fuel transformation in energy using several factors and efficiency aspects of engines and (ii) by taking into account the weight moved, distance, time, and emissions factor of each specific vehicle. Those approaches are unsuitable for understanding the impact of vehicles on CO in cities since vehicles produce CO depending on their specific efficiency, producer, fuel, weight, driver style, road conditions, seasons, etc. Read More

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A self-organized critical model and multifractal analysis for earthquakes in Central Alborz, Iran.

Sci Rep 2022 May 19;12(1):8364. Epub 2022 May 19.

Department of Physics, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran.

This paper is devoted to a phenomenological study of the earthquakes in central Alborz, Iran. Using three observational quantities, namely the weight function, the quality factor, and the velocity model in this region, we develop a modified dissipative sandpile model which captures the main features of the system, especially the average activity field over the region of study. The model is based on external stimuli, the location of which is chosen (I) randomly, (II) on the faults, (III) on the low active points, (IV) on the moderately active points, and (V) on the highly active points in the region. Read More

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Haemostatic alterations and management of haemostasis in patients with cirrhosis.

J Hepatol 2022 Jun;76(6):1291-1305

Division of Gastroenterology and Hepatology, Department of Medicine, Center for Coagulation in Liver Disease, University of Virginia Medical Center, Charlottesville VA, United States.

Patients with cirrhosis frequently acquire complex changes in their haemostatic system including a decreased platelet count and decreased levels of various haemostatic proteins. Although historically patients with cirrhosis were thought to have a haemostasis-related bleeding tendency, it is now widely accepted that the haemostatic system of patients with cirrhosis remains in balance as a result of simultaneous changes in pro- and anti-haemostatic systems. The concept of rebalanced haemostasis has led to changes in clinical management, although firm evidence from well-designed clinical studies is largely lacking. Read More

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A tutorial on multi-way data processing of excitation-emission fluorescence matrices acquired from semiconductor quantum dots sensing platforms.

Anal Chim Acta 2022 Jun 27;1211:339216. Epub 2021 Oct 27.

The Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) - the Portuguese Research Centre for Sustainable Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. Electronic address:

This tutorial demonstrates how to exploit the second-order advantage on excitation-emission fluorescence matrices (EEFMs) acquired from sensing platforms based on analyte-triggered semiconductor quantum dots (QDs) fluorescence modulation (quenching/enhancing). The advantage in processing such second-order EEFMs data from complex samples, seeking successful quantification, is comprehensively addressed. It is worth emphasizing that, aiming to exploit the second-order advantage, the selection of the most appropriate advanced chemometric model should rely on the matching between the data structure and the physicochemical chemometric model assumption. Read More

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Rutin Inhibits the Progression of Osteoarthritis Through -Mediated Signaling.

DNA Cell Biol 2022 May 19. Epub 2022 May 19.

Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Osteoarthritis (OA) is a chronic joint disease characterized by the deterioration of cartilage and subchondral bone in the joints. Currently, there is no complete cure for OA, only treatments designed to temporarily relieve pain and improve function. Compared with the high cost of surgical treatment, medical treatment of OA is more acceptable and cost-effective. Read More

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Genetics of atrial fibrillation-an update of recent findings.

Mol Biol Rep 2022 May 19. Epub 2022 May 19.

Multi-Disciplinary Center for Biomedical Research, Vinayaka Mission's Research Foundation, Aarupadai Veedu Medical College and Hospital, Puducherry, 607402, India.

Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. Read More

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Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children.

J Appl Lab Med 2022 May 19. Epub 2022 May 19.

Division of Critical Care Medicine, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Accurate assessment of hemostatic function is essential to guide care in critically ill children with acute and acquired coagulopathies. Thrombin generation (TG) provides a global assessment of procoagulant and anticoagulant factors and is commonly used in hemostasis research laboratories. Our objective was to determine the correlation of clinically available hemostasis assays with TG in critically ill children. Read More

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Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile.

Cancer Med 2022 May 19. Epub 2022 May 19.

Department of General Surgery II, the First People's Hospital of Yunnan Province, Kunming, Yunnan, China.

Background: Stage IV colorectal cancer patients with liver metastasis represent a special group of CRC patients with poor prognosis. The prognostic factors have not been investigated for stage IV CRC patients undergoing primary cancer resection but not candidates for metastasis resection.

Methods: Ninety-nine stage IV CRC patients who underwent primary cancer resection without metastasis resection were retrospectively recruited. Read More

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Efficacy of different intensity of aquatic exercise in enhancing remyelination and neuronal plasticity using cuprizone model in male Wistar rats.

Adv Clin Exp Med 2022 May 19. Epub 2022 May 19.

Department of Research and Development, Saveetha Insititute of Medical & Technical Sciences, Chennai, India.

Background: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). Most exercise studies concentrate on the impact of exercise on cardiovascular system; this study aims to present the effects of exercise of varying intensity on the nervous system. Most recently in MS, positive outcomes were obtained with resistance and high-intensity exercises. Read More

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Molecular Dynamics Simulations Indicate Aromaticity as a Key Factor in the Inhibition of IAPP Aggregation.

ACS Chem Neurosci 2022 May 19. Epub 2022 May 19.

Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.

Islet amyloid polypeptide (IAPP) is a 37-residue amyloidogenic hormone implicated in the progression of Type II Diabetes (T2D). T2D affects an estimated 422 million people yearly and is a comorbidity with numerous diseases. IAPP forms toxic oligomers and amyloid fibrils that reduce pancreatic β-cell mass and exacerbate the T2D disease state. Read More

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In-depth proteomics characterization of ∆Np73 effectors identifies key proteins with diagnostic potential implicated in lymphangiogenesis, vasculogenesis and metastasis in colorectal cancer.

Mol Oncol 2022 May 19. Epub 2022 May 19.

Departamento de Bioquímica, Facultad de Medicina, Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, IdiPAZ, E-28029, Madrid, Spain.

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Alterations in proteins of the p53family are a common event in CRC. ΔNp73, a p53-family member, shows oncogenic properties and its effectors are largely unknown. Read More

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Depression, worry, and loneliness are associated with subsequent risk of hospitalization for COVID-19: a prospective study.

Psychol Med 2022 May 19:1-10. Epub 2022 May 19.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Background: Pre-pandemic psychological distress is associated with increased susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but associations with the coronavirus disease 2019 (COVID-19) severity are not established. The authors examined the associations between distress prior to SARS-CoV-2 infection and subsequent risk of hospitalization.

Methods: Between April 2020 (baseline) and April 2021, we followed 54 781 participants from three ongoing cohorts: Nurses' Health Study II (NHSII), Nurses' Health Study 3 (NHS3), and the Growing Up Today Study (GUTS) who reported no current or prior SARS-CoV-2 infection at baseline. Read More

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