171,849 results match your criteria Factor II


Downregulation of SPARC Is Associated with Epithelial-Mesenchymal Transition and Low Differentiation State of Biliary Tract Cancer Cells.

Eur Surg Res 2019 Jan 16;60(1-2):1-12. Epub 2019 Jan 16.

Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim,

Background: Biliary tract cancers (BTCs) have a poor prognosis. BTCs are characterized by a prominent desmoplastic reaction which possibly contributes to the aggressive phenotype of this tumor. The desmoplastic reaction includes excessive production and deposition of extracellular matrix proteins such as periostin, secreted protein acidic and rich in cysteine (SPARC), thrombospondin-1, as well as accumulation of α-smooth muscle actin-positive cancer-associated fibroblasts and immune cells, secreting growth factors and cytokines including transforming growth factor (TGF)-β. Read More

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http://dx.doi.org/10.1159/000494734DOI Listing
January 2019

Significance of the preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the future remnant liver: a sequential study of regional maximal removal rate of technetium-99m-galactosyl human serum albumin in the whole liver.

Nucl Med Commun 2019 Feb;40(2):145-152

Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki.

Background: The relationship between posthepatectomy complications and liver functional parameters was preliminary reported in a pilot study. The present study sequentially evaluated the clinical significance of maximal removal rate of technetium-99m-galactosyl human serum albumin (GSARmax) in the future remnant liver (rGSARmax) in patients to predict posthepatectomy complications.

Methods: Between 2010 and August 2017, GSARmax, rGSARmax, their difference (Dif), and the rGSARmax to GSARmax ratio were examined in 247 additional patients who underwent hepatectomy for liver and biliary diseases. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000950DOI Listing
February 2019

Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS.

J Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

C Yu, Department of Gynecology of Traditional Chinese Medicine, Changhai hospital, Naval medical university, Shanghai, China.

High androgen levels in patients suffering from polycystic ovary syndrome (PCOS) can be effectively reversed if the herb Scutellaria baicalensis is included in traditional Chinese medicine prescriptions. To characterize the effects of baicalin, extracted from S. baicalensis, on androgen biosynthesis in NCI-H295R cells and on hyperandrogenism in PCOS model rats and to elucidate the underlying mechanisms. Read More

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http://dx.doi.org/10.1530/JOE-18-0678DOI Listing
January 2019

Faster oxygen uptake, heart rate and ventilatory kinetics in Stepping compared to Cycle ergometry in COPD patients during moderate intensity exercise.

Appl Physiol Nutr Metab 2019 Jan 16. Epub 2019 Jan 16.

Anhanguera Faculty, Physiotherapy, Porto Alegre, Rio Grande do Sul, Brazil ;

Although step tests are a stressful and feasible cost-effective modality to evaluate aerobic performance, the eccentric in addition to concentric muscle contractions of the legs on stepping emerge as a potential speeding factor for cardioventilatory and metabolic adjustments towards a steady-state, since eccentric contractions would prompt an earlier and stronger mechanoreceptor activation, besides higher heart rate/cardiac output adjustments to the same metabolic demand. Moreover, shorter tests are ideal for exercise-limited subjects. Nine COPD subjects were invited to participate in comprehensive lung function tests and replicated-on different days-constant work tests at a 90% gas exchange threshold for 6-min, in single-step tests or cycle ergometry. Read More

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http://dx.doi.org/10.1139/apnm-2018-0662DOI Listing
January 2019

Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma.

Turk Neurosurg 2018 Oct 17. Epub 2018 Oct 17.

Heinrich-Braun-Clinic.

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation.

Material And Methods: Specimens from 35 cases with glioblastoma multiforme and 23 cases with astrocytoma grade II were evaluated immunohistochemically. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.22739-18.3DOI Listing
October 2018

Esophageal carcinosarcoma that disappeared pathologically by palliative radiotherapy alone.

Clin J Gastroenterol 2019 Jan 16. Epub 2019 Jan 16.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.

Only a few cases of esophageal granulocyte-colony-stimulating-factor (G-CSF)-producing esophageal carcinosarcoma are reported, and patients with G-CSF-producing tumors are typically considered to have poor prognosis. An 89-year-old man was examined for low-grade fever and dysphagia. Chest computed tomography revealed a huge 80-mm tumor on the thoracic esophagus without direct invasion to surrounding organs. Read More

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http://dx.doi.org/10.1007/s12328-019-00933-7DOI Listing
January 2019

Clinical features, radiological findings, and treatment outcomes of high-grade lateral ventricular meningiomas: a report of 26 cases.

Neurosurg Rev 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, China.

High-grade meningiomas in ventricles are rare, where most published series only include a few patients. A retrospective analysis was performed on the clinical features, radiological findings, and treatment outcomes of 26 patients with high-grade meningiomas in lateral ventricles who were surgically treated in our hospital between July 2008 and July 2016. A female predilection (female/male = 1. Read More

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http://dx.doi.org/10.1007/s10143-019-01078-4DOI Listing
January 2019

Cardiovascular Risk Factors Associated With Venous Thromboembolism.

JAMA Cardiol 2019 Jan 16. Epub 2019 Jan 16.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

Importance: It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE).

Objective: To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism.

Design, Setting, And Participants: This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016). Read More

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http://dx.doi.org/10.1001/jamacardio.2018.4537DOI Listing
January 2019

The efficacy and safety of sunitinib given on an individualised schedule as first-line therapy for metastatic renal cell carcinoma: A phase 2 clinical trial.

Eur J Cancer 2019 Jan 12;108:69-77. Epub 2019 Jan 12.

Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada.

Background: Sunitinib is administered on a rigid schedule that may not be optimal for all patients. We hypothesised that toxicity-driven dose and schedule changes would optimise drug exposure and outcome for each patient.

Materials And Methods: In a phase 2 trial, 117 patients with metastatic clear cell renal cell cancer were started on sunitinib 50 mg/day with the aim to treat for 28 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183155
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http://dx.doi.org/10.1016/j.ejca.2018.12.006DOI Listing
January 2019
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Endothelium:a target for harmful actions of metals.

Curr Hypertens Rev 2019 Jan 15. Epub 2019 Jan 15.

CardiacElectromechanicaland Vascular ReactivityLaboratory, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468, Vitória, Espírito Santo. Brazil.

The use of heavy metals is closely linked to the history of mankind. They have been used as important materials in a wide variety of human activities such as manufacturing utensils and tools. Such extended use has significantly increased professional and environmental exposure to mercury, lead and cadmium. Read More

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http://dx.doi.org/10.2174/1573402115666190115153759DOI Listing
January 2019

Biochemical myogenic differentiation of ASC is donor-dependent and requires sound characterization.

Tissue Eng Part A 2019 Jan 16. Epub 2019 Jan 16.

Hannnover Medical School, Lower Saxony centre of biotechnology implant research and development (NIFE), Hannover, Germany.

Vascular tissue engineering approaches often require autologous smooth muscle cells (SMC) obtained by biochemical differentiation of donor-derived adipogenic stem cells (ASC) by transforming growth factor-β (TGFβ), bone morphorgenetic protein-4 (BMP4) and/or sphingosylphosphorylcholine (SPC). However, data on myogenic marker proteins and contractility indicating fully functional SMC is contradicting and incomplete. We here investigated (i) the ideal combination of TGFβ, BMP4 and/or SPC; the time frame (ii) necessary to trigger myogenic differentiation and (iii) for a sustained differentiation status up to 29 days; and (iv) donor diversity in myogenic differentiation potential and contractility using collagen and fibrin gel assays. Read More

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http://dx.doi.org/10.1089/ten.TEA.2018.0172DOI Listing
January 2019

Single-Crystal Study of a Low Spin Co(II) Molecular Qubit: Observation of Anisotropic Rabi Cycles.

Inorg Chem 2019 Jan 16. Epub 2019 Jan 16.

Beijing National Laboratory for Molecular Sciences, Beijing Key Laboratory of Magnetoelectric Materials and Devices, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , China.

A mononuclear low spin ( S = 1/2) Co(II) molecule crystallized in a 4-fold symmetry is fully investigated by CW and pulsed EPR on a single crystal sample. The quantum phase memory time of the molecule around 1 μs at 5 K is direction-independent, while the Rabi oscillation frequency is anisotropic. The spin Hamiltonian analyses reveal that the anisotropic Landé factor and hyperfine tensor do not influence the anisotropy apparently when the microwave magnetic field is applied along a certain direction. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b02685DOI Listing
January 2019

Cryopreserved H O -preconditioned human adipose-derived stem cells exhibit fast post-thaw recovery and enhanced bioactivity against oxidative stress.

J Tissue Eng Regen Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Surgery, Radiology and Physical Medicine, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.

Human adipose-derived stem cells (ASCs), despite being one of the most attractive cell populations for tissue engineering and regenerative medicine, currently have certain limitations that reduce their therapeutic efficacy. One of the most serious problems is the poor engraftment of cryopreserved ASCs at injured tissue, attributed to the diminished biological activity of ASCs immediately post-thaw and their poor survival under harsh conditions of oxidative stress. Seeking to address these issues, we have developed a hormetic strategy to pre-adapt human ASCs to oxidative stress based on a new hydrogen peroxide preconditioning procedure, resulting in cells we call HC016. Read More

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http://dx.doi.org/10.1002/term.2797DOI Listing
January 2019

Chinese translation of a measure of symptom burden, functional limitations, lifestyle, and health care-seeking skills in breast cancer survivors: the Cancer Survivor Profile.

J Cancer Surviv 2019 Jan 16. Epub 2019 Jan 16.

, Gaithersburg, USA.

Purpose: To produce a culturally sensitive Chinese translation of the original version of the Cancer Survivor Profile for breast cancer (CSPro-BC) survivors, which identifies problems in breast cancer patients post-primary treatment for breast cancer.

Methods: Four hundred forty-four female Chinese patients following primary treatment for breast cancer completed a Chinese translation of the CSPro-BC. Participants were randomly divided into two equal groups (n = 222). Read More

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http://dx.doi.org/10.1007/s11764-019-0733-0DOI Listing
January 2019

Therapeutic Options in Pregnant Women with Thrombophilia Depending on the Genetic Mutations- a Prospective Study.

Curr Health Sci J 2018 Jul-Sep;44(3):288-293. Epub 2018 Jul 15.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania.

The aim is to evaluate the effects of anticoagulant therapy (Enoxaparine) compared to antiaggregant therapy (Aspirin) on pregnancy outcome depending on the mutational status of clotting factors. The study was conducted prospectively over a 2 years period and included 110 pregnant women, of whom 80 patients diagnosed with hereditary thrombophilia and 30 healthy pregnant women, representing the control group. After careful observation, we concluded a positive influence of Enoxaparine on pregnancy outcome in pregnant women homozygous carriers for factor V Leiden gene mutation and compound heterozygous for Factor V Leiden and Prothrombin G20210A gene mutation. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311225PMC
July 2018
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Antifibrotic Effect of Marine Ovothiol in an Model of Liver Fibrosis.

Oxid Med Cell Longev 2018 17;2018:5045734. Epub 2018 Dec 17.

Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy.

Liver fibrosis is a complex process caused by chronic hepatic injury, which leads to an excessive increase in extracellular matrix protein accumulation and fibrogenesis. Several natural products, including sulfur-containing compounds, have been investigated for their antifibrotic effects; however, the molecular mechanisms underpinning their action are partially still obscure. In this study, we have investigated for the first time the effect of ovothiol A, -methyl-5-thiohistidine, isolated from sea urchin eggs on an murine model of liver fibrosis. Read More

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http://dx.doi.org/10.1155/2018/5045734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311726PMC
December 2018

Acute Pyelonephritis: A Single-center Experience.

Indian J Nephrol 2018 Nov-Dec;28(6):454-461

Department of Nephrology, Institute of Nephro Urology, Victoria Hospital Campus, Bengaluru, Karnataka, India.

Acute pyelonephritis (APN), although a common clinical entity, still not much is known about the clinical profile in the Indian scenario. We prospectively collected clinical, biochemical, and radiological data of patients hospitalized with a diagnosis of APN from March 2014 to June 2016. A total of 296 cases were included in the study. Read More

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http://dx.doi.org/10.4103/ijn.IJN_219_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309380PMC
January 2019

ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma.

J Exp Clin Cancer Res 2019 Jan 15;38(1):18. Epub 2019 Jan 15.

Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Absract: BACKGROUND: Tumor metastasis is the major reason for poor prognosis of hepatocellular carcinoma (HCC) patients after hepatic resection. SMYD3 has been demonstrated to promote liver tumor metastasis in mice. However, the detailed molecular mechanism is still largely unknown. Read More

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http://dx.doi.org/10.1186/s13046-018-1011-0DOI Listing
January 2019

Body mass index as an independent risk factor for inferior vena cava resection during thrombectomy for venous tumor thrombus of renal cell carcinoma.

World J Surg Oncol 2019 Jan 15;17(1):17. Epub 2019 Jan 15.

Department of Urology, Peking University Third Hospital, Beijing, China.

Objective: To define preoperative clinical and radiographic risk factors for the need of inferior vena cava (IVC) resection in patients with renal cell carcinoma (RCC) and IVC tumor thrombus.

Methods: We reviewed data of 121 patients with renal cell carcinoma and venous tumor thrombus receiving radical nephrectomy and thrombectomy at our institution between 2015 and 2017, and 86 patients with Mayo I-IV level tumor thrombus were included in the final analysis. Clinical features, operation details, and pathology data were collected. Read More

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http://dx.doi.org/10.1186/s12957-019-1560-5DOI Listing
January 2019

New insights in the control of antioxidants accumulation in tomato by transcriptomic analyses of genotypes exhibiting contrasting levels of fruit metabolites.

BMC Genomics 2019 Jan 15;20(1):43. Epub 2019 Jan 15.

Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy.

Background: Tomato is an economically important crop with fruits that are a significant source of bioactive compounds such as ascorbic acid and phenolics. Nowadays, the majority of the enzymes of the biosynthetic pathways and of the structural genes controlling the production and the accumulation of antioxidants in plants are known; however, the mechanisms that regulate the expression of these genes are yet to be investigated. Here, we analyzed the transcriptomic changes occurring during ripening in the fruits of two tomato cultivars (E1 and E115), characterized by a different accumulation of antioxidants, in order to identify candidate genes potentially involved in the biosynthesis of ascorbic acid and phenylpropanoids. Read More

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http://dx.doi.org/10.1186/s12864-019-5428-4DOI Listing
January 2019

c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells.

Int J Mol Sci 2019 Jan 14;20(2). Epub 2019 Jan 14.

Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, "Sapienza" University of Rome, 00161 Rome, Italy.

c-MET pathway over-activation is the signature of malignancy acquisition or chemotherapy resistance of many cancers. We recently demonstrated that type II Testicular Germ Cell Tumours (TGCTs) express c-MET receptor. In particular, we elucidated that the non-seminoma lesions express c-MET protein at higher level, compared with the seminoma ones. Read More

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http://dx.doi.org/10.3390/ijms20020320DOI Listing
January 2019

Effect of a Qigong Intervention on Telomerase Activity and Mental Health in Chinese Women Survivors of Intimate Partner Violence: A Randomized Clinical Trial.

JAMA Netw Open 2019 Jan 4;2(1):e186967. Epub 2019 Jan 4.

School of Nursing, Hong Kong Sanatorium and Hospital, Wong Chuk Hang, Hong Kong, China.

Importance: Qigong is a mind-body exercise that may be an effective self-care intervention for improving the well-being of women survivors of intimate partner violence.

Objective: To test whether a qigong intervention would increase telomerase activity and improve mental health in Chinese women who survived intimate partner violence.

Design, Setting, And Participants: A single-blind randomized clinical trial among Chinese women (N = 271) who survived intimate partner violence in the past 2 years recruited from a community center in Hong Kong, China. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6967DOI Listing
January 2019
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Blood markers of cardiac stress after generalized convulsive seizures.

Epilepsia 2019 Jan 15. Epub 2019 Jan 15.

Department of Epileptology, University Hospital Bonn, Bonn, Germany.

Objective: Generalized convulsive seizures (GCS) are associated with high demands on the cardiovascular system, thereby facilitating cardiac complications. To investigate occurrence, influencing factors, and extent of cardiac stress or injury, the alterations and time course of the latest generation of cardiac blood markers were investigated after documented GCS.

Methods: Adult patients with refractory epilepsy who underwent video-electroencephalography (EEG) monitoring along with simultaneous one-lead electrocardiography (ECG) recordings were included. Read More

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http://doi.wiley.com/10.1111/epi.14637
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http://dx.doi.org/10.1111/epi.14637DOI Listing
January 2019
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Autophagy Activation Improves Lung Injury and Inflammation in Sepsis.

Inflammation 2019 Jan 15. Epub 2019 Jan 15.

Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anesthesiology, Tianjin, 300052, People's Republic of China.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) undergoes the process of pathological event including lung tissue dysfunction, pulmonary edema, and inflammation in sepsis. Autophagy is a cytoprotective process recognized as one of the major pathways for degradation and recycling of cellular constituents. Autophagy as a protective or maladaptive response was still confused in ALI during sepsis. Read More

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http://dx.doi.org/10.1007/s10753-018-00952-5DOI Listing
January 2019
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Competing risks of major bleeding and thrombotic events with prasugrel-based dual antiplatelet therapy after stent implantation - An observational analysis from BASKET-PROVE II.

PLoS One 2019 15;14(1):e0210821. Epub 2019 Jan 15.

Cardiology, University Hospital Basel, University Basel, Basel, Switzerland.

Background: Dual antiplatelet therapy (DAPT) prevents thrombotic events after coronary stent implantation but may induce bleedings, specifically in elderly patients. However, a competitive risk analysis is lacking.

Objectives: To assess the determinants of major bleeding and the balance between the competing risks of major bleeding and thrombotic events during prasugrel-based DAPT after stent implantation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210821PLOS
January 2019
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Mask-based approach to phasing of single-particle diffraction data. II. Likelihood-based selection criteria.

Acta Crystallogr D Struct Biol 2019 Jan 8;75(Pt 1):79-89. Epub 2019 Jan 8.

Centre for Integrative Biology, IGBMC, CNRS-INSERM-UdS, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch, France.

A new type of mask-selection criterion is suggested for mask-based phasing. In this phasing approach, a large number of connected molecular masks are randomly generated. Structure-factor phases corresponding to a trial mask are accepted as an admissible solution of the phase problem if the mask satisfies some specified selection rules that are key to success. Read More

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http://dx.doi.org/10.1107/S2059798318016959DOI Listing
January 2019

Experimental Study on the Prevention of Posttraumatic Osteoarthritis in the Rabbit Knee Using a Hinged External Fixator in Combination with Exercises.

Authors:
Zhi-Bo Sun Hao Peng

J Invest Surg 2019 Jan 15:1-8. Epub 2019 Jan 15.

a Department of Orthopedics , Renmin Hospital, Wuhan University , Wuhan , Hubei 430060 , China.

Objective: To report the design and effect of our proprietary hinged external fixator, used in combination with treadmill exercise for rabbits with intra-articular inflammation and cartilage degeneration.

Methods: Thirty-two white rabbits were randomly allocated into four groups: No treatment (NT), Distraction only (D), Exercise only (Ex), and Distraction plus exercise (D + Ex). Each rabbit underwent an anterior cruciate ligament transection on the right knee, with the contralateral knee used as a sham control (C). Read More

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https://www.tandfonline.com/doi/full/10.1080/08941939.2018.1
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http://dx.doi.org/10.1080/08941939.2018.1543483DOI Listing
January 2019
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Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.

J Thromb Haemost 2019 Jan 15. Epub 2019 Jan 15.

Department of Biosciences, University of Salzburg, Billrothstr. 11, A-5020, Salzburg, Austria.

Background: Vitamin K (VK)-dependent proteases are major players in blood coagulation including the initiation as well as the regulation of the cascade. Five different members of this protease family have been described comprising the coagulation factors VII (FVII), IX (FIX), X (FX), protein C (PC) and prothrombin (FII). FVII, FIX, FX and PC share a typical domain architecture with a N-terminal Gla (γ-carboxyglutamate)-domain, two EGF (epidermal growth factor-like)-domains and a C-terminal trypsin-like serine protease (SP)-domain. Read More

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http://dx.doi.org/10.1111/jth.14384DOI Listing
January 2019

Enhancement of the Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Repair by Ghrelin.

J Orthop Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China.

Transforming growth factor beta (TGF-β) is commonly utilized in chondrogenic differentiation protocols, but this often results in incomplete maturation of the derived chondrocytes. Gene expression analysis, quantitation of sulfated glycosaminoglycan and collagen, and histological staining were performed to assess the effects of ghrelin. The signaling pathways involved were investigated with inhibitors or targeted by shRNAs. Read More

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http://dx.doi.org/10.1002/jor.24224DOI Listing
January 2019

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.

Cell Death Differ 2019 Jan 15. Epub 2019 Jan 15.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.

Necroptosis is a programmed form of necrotic cell death, which is tightly regulated by the necroptotic signaling pathway containing receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like (MLKL) protein. In addition to the RIP1-RIP3-MLKL axis, other factors regulating necroptosis are still largely unknown. Here a cell-based small-molecule screening led to the finding that BET inhibitors protected cells from necroptosis in the TNFα/Smac-mimetic/Z-VAD-FMK (TSZ)-induced cell necroptosis model. Read More

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http://dx.doi.org/10.1038/s41418-018-0262-9DOI Listing
January 2019

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Nat Commun 2019 Jan 15;10(1):224. Epub 2019 Jan 15.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.

Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2 promotes RAF-to-MAPK signaling pathway and is an essential factor in RAS-driven oncogenesis. Despite the emergence of SHP2 inhibitors for the treatment of cancers harbouring mutant KRAS, the mechanism underlying SHP2 activation of KRAS signaling remains unclear. Read More

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http://dx.doi.org/10.1038/s41467-018-08115-8DOI Listing
January 2019

Outcome of non-mold effective anti-fungal prophylaxis in patients at high-risk for invasive fungal infections after allogenic stem cell transplantation.

Leuk Lymphoma 2019 Jan 15:1-6. Epub 2019 Jan 15.

a Department of Hematology, Oncology and Immunology , University Hospital Giessen and Marburg , Marburg , Germany.

Patients who develop severe graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (alloSCT) have a higher risk for invasive fungal infection (IFI). At our center, fluconazole prophylaxis is standard and upfront mold-effective prophylaxis performed only in patients with specific risk constellations. A total of 290 patients undergoing alloSCT between May 2002 and August 2011 were analyzed. Read More

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http://dx.doi.org/10.1080/10428194.2018.1553303DOI Listing
January 2019

Health-Related Quality of Life in Patients with CVID Under Different Schedules of Immunoglobulin Administration: Prospective Multicenter Study.

J Clin Immunol 2019 Jan 15. Epub 2019 Jan 15.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Objective: We assessed the health-related quality of life (HRQoL) in CVID adults receiving different schedules of immunoglobulin replacement therapy (IgRT) by intravenous (IVIG), subcutaneous (SCIG), and facilitated (fSCIG) preparations. For these patients, IgRT schedule was chosen after a period focused on identifying the most suitable individual option.

Methods: Three hundred twenty-seven participants were enrolled in a prospective, observational, 18-month study. Read More

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http://dx.doi.org/10.1007/s10875-019-0592-5DOI Listing
January 2019

In Situ Investigation of Interrelationships Between Morphology and Biomechanics of Endothelial and Glial Cells and their Nuclei.

Adv Sci (Weinh) 2019 Jan 10;6(1):1801638. Epub 2018 Nov 10.

Institute of Physiology II University of Münster Robert-Koch Str. 27b 48149 Münster Germany.

Morphology and biomechanics of cells and nuclei are interlinked with one another and play key roles in fundamental physiological processes. While powerful approaches are available for performing separate morphological and biomechanical investigations on cells and nuclei, simultaneous investigations in situ are challenging. Here, an appropriate approach is presented based on the simultaneous combination of atomic force microscopy and confocal microscopy in situ. Read More

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http://dx.doi.org/10.1002/advs.201801638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325600PMC
January 2019

Comparison of Survival in Patients with Isolated Peritoneal Carcinomatosis from Colorectal Cancer Treated with Cytoreduction and Melphalan or Mitomycin-C as Hyperthermic Intraperitoneal Chemotherapy Agent.

Int J Surg Oncol 2018 13;2018:1920276. Epub 2018 Dec 13.

Surgical Oncology Department, Mercy Medical Center, Baltimore, Maryland, 21202, USA.

Background: The role of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is debated. Melphalan as a perfusion agent has also demonstrated survival benefit in other recurrent and chemoresistant malignancies. Thus, we hypothesize that melphalan as a HIPEC agent may improve overall survival (OS) and progression-free survival (PFS) in patients with PC from CRC. Read More

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http://dx.doi.org/10.1155/2018/1920276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311272PMC
December 2018

Routine Preoperative Coagulation Tests in Children Undergoing Elective Surgery or Invasive Procedures: Are They Still Necessary?

Clin Med Insights Blood Disord 2019 5;12:1179545X18821158. Epub 2019 Jan 5.

Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Introduction: Preoperative coagulation screening tests in pediatric patients was once routine clinical practice globally and still used as standard practice in some countries before surgical procedures to assess of perioperative bleeding risk.

Objective: The study aimed to evaluate unselected routine preoperative coagulation testing in children undergoing elective or invasive surgery to predict abnormal perioperative bleeding. The study also aimed to provide a rational approach of determining bleeding and family history of coagulation disorders as a predictive risk for bleeding. Read More

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http://dx.doi.org/10.1177/1179545X18821158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322095PMC
January 2019

Primary systemic therapy in HER2-positive operable breast cancer using trastuzumab and chemotherapy: efficacy data, cardiotoxicity and long-term follow-up in 142 patients diagnosed from 2005 to 2016 at a single institution.

Breast Cancer (Dove Med Press) 2019 27;11:29-42. Epub 2018 Dec 27.

Medical Oncology Department, Breast Unit, A Coruña University Hospital, A Coruña, Spain,

Objective: The aim of this study was to evaluate the efficacy, cardiotoxicity profile and long-term benefits of neoadjuvant therapy in human epidermal growth factor receptor 2-positive operable breast cancer patients.

Patients And Methods: A total of 142 patients diagnosed from 2005 to 2016 were included in the study. The treatment consisted of a sequential regimen of taxanes and anthracyclines plus trastuzumab. Read More

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https://www.dovepress.com/primary-systemic-therapy-in-her2-p
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http://dx.doi.org/10.2147/BCTT.S179750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311333PMC
December 2018
2 Reads

Prognostic value of preoperative exercise capacity in patients undergoing thoracoscopic lobectomy for non-small cell lung cancer.

Lung Cancer 2019 Feb 16;128:47-52. Epub 2018 Dec 16.

Department of Thoracic Surgery, Shin-Kokura Hospital, Federation of National Public Service Personnel Mutual Aid Associations, 1-3-1 Kanada, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8505, Japan. Electronic address:

Objectives: Whether or not the preoperative exercise capacity, as assessed by 6-min walk test, influences the survival of patients undergoing thoracoscopic lobectomy for lung cancer is unclear. We therefore investigated the prognostic value of the 6-min walk distance in this population.

Materials And Methods: This prospective cohort study was conducted between 2005 and 2013. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.12.013DOI Listing
February 2019

Who knows best? A Q methodology study to explore perspectives of professional stakeholders and community participants on health in low-income communities.

BMC Health Serv Res 2019 Jan 14;19(1):35. Epub 2019 Jan 14.

Yunus Centre for Social Business and Health, Glasgow Caledonian University, M201, 2nd Floor, George Moore Building, Cowcaddens Road, Glasgow, G4 OBA, Scotland.

Background: Health inequalities in the UK have proved to be stubborn, and health gaps between best and worst-off are widening. While there is growing understanding of how the main causes of poor health are perceived among different stakeholders, similar insight is lacking regarding what solutions should be prioritised. Furthermore, we do not know the relationship between perceived causes and solutions to health inequalities, whether there is agreement between professional stakeholders and people living in low-income communities or agreement within these groups. Read More

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http://dx.doi.org/10.1186/s12913-019-3884-9DOI Listing
January 2019

Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth.

Int J Mol Sci 2019 Jan 12;20(2). Epub 2019 Jan 12.

Molecular Pathology Unit, IRCCS Polyclinic Hospital San Martino, L.go R. Benzi n.10, 16132 Genova, Italy.

Chronic lymphocytic leukemia (CLL) is characterized by the progressive expansion of B lymphocytes CD5+/CD23+ in peripheral blood, lymph-nodes, and bone marrow. The pivotal role played by the microenvironment in disease pathogenesis has become increasingly clear. We demonstrated that bone marrow stromal cells and trabecular bone cells sustain survival of leukemic B cells through the production of hepatocyte growth factor (HGF). Read More

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http://www.mdpi.com/1422-0067/20/2/292
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http://dx.doi.org/10.3390/ijms20020292DOI Listing
January 2019
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Association of TLR4 Polymorphisms, Expression, and Vitamin D with Helicobacter pylori Infection.

J Pers Med 2019 Jan 11;9(1). Epub 2019 Jan 11.

Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut 1107 2809, Lebanon.

Helicobacter pylori () infection is the strongest recognized risk factor for gastric adenocarcinoma. Since previous observations have shown that polymorphisms in innate immune system genes, as well as vitamin D (VitD) levels, could modify the risk of infection with (), we analyzed the relation between single nucleotide polymorphisms (SNPs) in (, , ) , and VitD levels with infection. A case-control study on four hundred sixty Lebanese individuals was conducted. Read More

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http://www.mdpi.com/2075-4426/9/1/2
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http://dx.doi.org/10.3390/jpm9010002DOI Listing
January 2019
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Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma.

J Neurosurg 2019 Jan 11:1-12. Epub 2019 Jan 11.

1School of Medicine, Chang Gung University, Taoyuan.

OBJECTIVEDespite intensive medical treatment, patients with glioblastoma (grade IV glioma [GBM]) have a low 5-year survival rate of 5.5%. In this study, the authors tried to improve currently used therapies by identification of a therapeutic target, IGFBP3, for glioma treatment. Read More

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http://dx.doi.org/10.3171/2018.8.JNS181217DOI Listing
January 2019

Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):24-29. Epub 2018 Aug 11.

Internal Medicine Department, Faculty of Medicine, Tanta University, El-Geesh Street, Tanta, Egypt.

Obesity is the main determinant of type 2 diabetes. Some adipocytokines play important roles in diabetic complications. Lipid transport is an important aspect of lipid metabolism in cancer. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.08.005DOI Listing

Ruthenium(II) polypyridyl complex [Ru(phen)dppz-idzo] as a colorimetric molecular "light switch" and powerful stabilizer for the RNA triplex poly(U)·poly(A)*poly(U).

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 28;212:240-245. Epub 2018 Dec 28.

Key Lab of Environment-friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China. Electronic address:

The interaction of [Ru(phen)dppz-idzo] (phen = 1,10-phenanthroline, dppz-idzo = dppz-imidazolone) with triplex RNA poly(U)·poly(A)*poly(U) was carried out by using spectroscopic and viscometric techniques in this work. Luminescent titrations suggest that [Ru(phen)dppz-idzo] shows better selectivity for poly(U)·poly(A)*poly(U) compared with poly(U)·poly(A) and poly(U), this complex exhibits a "light switch" effect with an emission enhancement factor of about 123 in the presence of poly(U)·poly(A)*poly(U). Significantly, this "light switch" behavior could even be observed by the naked eye under irradiation with UV light. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425183111
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http://dx.doi.org/10.1016/j.saa.2018.12.048DOI Listing
December 2018
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Self-treatment with herbal products for weight-loss among overweight and obese subjects from central Mexico.

J Ethnopharmacol 2019 Jan 11. Epub 2019 Jan 11.

Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, México.

Ethnopharmacological Relevance: Mexico ranks second in the world for obesity prevalence. In Mexico, obese and overweight subjects commonly seek alternative treatments for weight-loss, including the use of herbal products.

Aim Of The Study: The main objective of this study was to evaluate the prevalence of self-medication with herbal products for weight-loss among overweight and obese subjects residing in four states (Guanajuato, San Luis Potosi, State of Mexico, and Mexico City) from central Mexico. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.003DOI Listing
January 2019

Time-course effects of antioxidants and phase II enzymes on diesel exhaust particles-induced oxidative damage in the mouse lung.

Toxicol Appl Pharmacol 2019 Jan 11. Epub 2019 Jan 11.

School of Public Health, Qingdao University, Dengzhou Road 38, Qingdao 266021, Shandong Province, China; National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Xicheng District, 29 Nanwei Road, Beijing 100050, China. Electronic address:

Mechanisms responsible for diesel exhaust particle (DEP)-induced toxicity in respiratory disorders are poorly understood, recent experimental and controlled exposure studies suggested that oxidative stress might be involved. To investigate the time-course effects DEP on nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator in cellular adaptive antioxidant response, mice were intratracheal instilled with 100 μg DEP/mouse and sacrificed after 30 min, 6 h, 12 h, 24 h, 48 h, and 72 h. We measured reactive oxygen species (ROS) as well as Nrf2 and antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and phase II enzymes including heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase-1 (NQO1), glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase modifier subunit (GCLM) in the lungs. Read More

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http://dx.doi.org/10.1016/j.taap.2019.01.010DOI Listing
January 2019

A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.

Arch Biochem Biophys 2019 Jan 11. Epub 2019 Jan 11.

Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan. Electronic address:

The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of luteolin over its physiological concentration range. Read More

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http://dx.doi.org/10.1016/j.abb.2019.01.012DOI Listing
January 2019

Polyomavirus BK, BKV microRNA, and urinary neutrophil gelatinase-associated lipocalin can be used as potential biomarkers of lupus nephritis.

PLoS One 2019 14;14(1):e0210633. Epub 2019 Jan 14.

Kidney Research Center and Department of Nephrology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Objective: Lupus nephritis (LN) frequently progresses to end-stage renal disease. Finding a biomarker for LN and a predictor for the development of chronic kidney disease (CKD) is important for patients with systemic lupus erythematosus (SLE).

Methods: Ninety patients with SLE were divided into biopsy-proven LN (n = 54) and no kidney involvement (non-LN) (n = 36) groups and followed up for 54 months. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210633PLOS
January 2019

The use of new procoagulants in blunt and penetrating trauma.

Curr Opin Anaesthesiol 2019 Jan 11. Epub 2019 Jan 11.

Katharine Dormandy Haemophilia and Thrombosis Centre, Dept. of Haematology, Royal Free Hospital, London, UK.

Purpose Of Review: Uncontrolled bleeding in trauma secondary to a combination of surgical bleeding and trauma-induced complex coagulopathy is a leading cause of death. Prothrombin complex concentrates (PCCs), recombinant activated factor seven (rFVIIa) and recombinant human prothrombin act as procoagulants by increasing thrombin generation and fibrinogen concentrate aids stable clot formation. This review summarizes current evidence for procoagulant use in the management of bleeding in trauma, and data and evidence gaps for routine clinical use. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000696DOI Listing
January 2019

Characterization of the Systemic Findings of Patients Undergoing Initiation of Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema in Routine Clinical Practice.

Ophthalmic Surg Lasers Imaging Retina 2019 Jan;50(1):16-24

Background And Objectives: Previous studies have validated that baseline visual acuity (VA) can predict a variance response to anti-vascular endothelial growth factor (VEGF) treatment. However, little is known about the initial systemic presentation of diabetic macular edema (DME) in clinical practice. The aim of this study is to report the baseline systemic findings of patients presenting with DME who received anti-VEGF in clinical practice. Read More

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http://dx.doi.org/10.3928/23258160-20181212-03DOI Listing
January 2019