190,529 results match your criteria Factor II

Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent.

Blood Cells Mol Dis 2021 Apr 23;89:102570. Epub 2021 Apr 23.

Research and Development, CSL Behring Innovation GmbH, Marburg, Germany.

Hemophilia A and hemophilia B are X-linked inherited bleeding disorders caused by a deficiency of coagulation factor VIII and IX, respectively. Standard of care is prophylactic factor replacement therapy; however, the development of neutralizing antibodies against these factors represents serious complications underlining the need for alternative treatment approaches. Human coagulation factor X has a central role within the blood coagulation system making it an attractive target for the development of alternative treatment strategies for patients with hemophilia. Read More

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MRI based radiomics in nasopharyngeal cancer: Systematic review and perspectives using radiomic quality score (RQS) assessment.

Eur J Radiol 2021 Apr 30;140:109744. Epub 2021 Apr 30.

Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy; Laboratory of Augmented Reality for Health Monitoring (ARHeMLab), Department of Electrical Engineering and Information Technology, University of Naples "Federico II", Naples, Italy.

Background: MRI based radiomics has the potential to better define tumor biology compared to qualitative MRI assessment and support decisions in patients affected by nasopharyngeal carcinoma. Aim of this review was to systematically evaluate the methodological quality of studies using MRI- radiomics for nasopharyngeal cancer patient evaluation.

Methods: A systematic search was performed in PUBMED, WEB OF SCIENCE and SCOPUS using "MRI, magnetic resonance imaging, radiomic, texture analysis, nasopharyngeal carcinoma, nasopharyngeal cancer" in all possible combinations. Read More

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The insulin-like growth factors: ligands, binding proteins and receptors.

Mol Metab 2021 May 4:101245. Epub 2021 May 4.

The insulin-like growth factor family of ligands (IGF-I, IGF-II and insulin), receptors (IGF-IR, M6P/IGF-IIR and the insulin receptor, IR) as well as the IGF binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states. Insulin and the insulin receptors are the focus of other chapters in this series and will therefore not be discussed further. IGF-I has effects via the circulation and locally within tissues to regulate cellular growth, differentiation and survival thereby controlling overall body growth. Read More

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Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.

Am J Hum Genet 2021 May;108(5):857-873

GeneDx, Gaithersburg, MD 20877, USA.

The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants in the degron of AFF3, a nine amino acid sequence important for its binding to ubiquitin ligase, or with de novo deletions of this region. The sixteen affected individuals we identified, along with two previously reported individuals, present with a recognizable pattern of anomalies, which we named KINSSHIP syndrome (KI for horseshoe kidney, NS for Nievergelt/Savarirayan type of mesomelic dysplasia, S for seizures, H for hypertrichosis, I for intellectual disability, and P for pulmonary involvement), partially overlapping the AFF4-associated CHOPS syndrome. Read More

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Serum Levels of the IgA Isotype Switch Factor TGF-β1 are Elevated in Patients with COVID-19.

FEBS Lett 2021 May 7. Epub 2021 May 7.

State Key Laboratory of Respiratory Disease for Allergy at, Shenzhen University, Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, 518061, China.

We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-β1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-β1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE-II score in patients with severe disease. Read More

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Staff and participant perceptions of optimal recruitment and retention strategies for biomedical cohort studies in the Caribbean.

Cancer Causes Control 2021 May 7. Epub 2021 May 7.

Division of Health Equities, City of Hope Medical Center, Center of Community Alliance for Research & Education, Duarte, CA, USA.

Purpose: To identify staff and participants perspectives of best practices that facilitate achieving enrollment and retention targets in biomedical cohort studies in Caribbean populations.

Methods: Eight focus group discussions (FGDs) were held with research stakeholders including research (i) nurses/study supervisors, (ii) field staff/data collectors, and (iii) rural and urban participants of the Third Jamaica Health and Lifestyle Survey (a national NCD risk factor survey with biospecimen collection) to capture qualitative data on experiences with recruitment, training, retention challenges and potential solutions or strategies for strengthening future efforts.

Results: Our findings indicate that trained, experienced study staff with good interpersonal communication skills enhanced the proficiency of field operations and attracted study participants. Read More

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Synthesis of a PVA drug delivery system for controlled release of a Tramadol-Dexketoprofen combination.

J Mater Sci Mater Med 2021 May 7;32(5):56. Epub 2021 May 7.

Facultad de Odontología, Región Orizaba-Córdoba, Universidad Veracruzana, Abasolo Sur, SN, Tenango de Río Blanco, 94732, Veracruz, México.

The local administration of analgesic combinations by means of degradable polymeric drug delivery systems is an alternative for the management of postoperative pain. We formulated a Tramadol-Dexketoprofen combination (TDC) loaded in poly(vinyl alcohol) (PVA) film. Films were prepared by the solvent casting method using three different molecular weights of PVA and crosslinking those films with citric acid, with the objective of controlling the drug release rate, which was evaluated by UV-vis spectrometry. Read More

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First-time anterior cruciate ligament injury in adolescent female elite athletes: a prospective cohort study to identify modifiable risk factors.

Knee Surg Sports Traumatol Arthrosc 2021 May 7. Epub 2021 May 7.

Human Movement Analysis Laboratory, Department of Orthopedic Surgery, Copenhagen University Hospital, Amager-Hvidovre, Hvidovre, Denmark.

Purpose: To identify modifiable biomechanical and neuromuscular anterior cruciate ligament (ACL) injury risk factors for first-time ACL injury in adolescent female elite football and team handball players.

Methods: Adolescent female elite football and handball players with no previous ACL injury participated in the present study. At baseline, players were tested during side-cutting manoeuvres performed in a 3-dimensional motion analysis laboratory with concomitant electromyography (EMG) measurements. Read More

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[Position paper of the Italian Society of Cardiology (SIC) on COVID-19 vaccine priority in patients with cardiovascular diseases].

G Ital Cardiol (Rome) 2021 May;22(5):363-375

Società Italiana di Cardiologia, Roma - Mediterranea Cardiocentro, Napoli - Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli "Federico II", Napoli.

In over a year, the COVID-19 pandemic caused 2.69 million deaths and 122 million infections. Social isolation and distancing measures have been the only prevention available for months. Read More

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The efficacy of radiofrequency ablation versus cryoablation in the treatment of single hepatocellular carcinoma: A population-based study.

Cancer Med 2021 May 7. Epub 2021 May 7.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Radiofrequency ablation (RFA) is an effective treatment for single hepatocellular carcinoma (HCC), but it is difficult to use against tumors in some locations and often leads to incomplete ablation as a result of the heat-sink effect. This study was conducted to evaluate the efficacy of cryoablation compared with that of RFA in the treatment of single HCC.

Methods: This retrospective study was conducted based on the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR.

J Cell Mol Med 2021 May 7. Epub 2021 May 7.

Department of Orthopedics, Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light-emitting diodes (LED)-based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Read More

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Glucose -regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers and neurological disorders.

IUBMB Life 2021 May 7. Epub 2021 May 7.

Department of Pathology, Duke University Medical Center, Durham, North Carolina.

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER. In response to cellular stress, GRP78 escapes from the ER and moves to the plasma membrane where it (i) functions as a receptor for many ligands, and (ii) behaves as an autoantigen for autoantibodies that contribute to human disease and cancer. Read More

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High light-induced photoinhibition is not limiting seedling establishment at abrupt treeline ecotones in New Zealand.

Tree Physiol 2021 May 7. Epub 2021 May 7.

School of Science, Auckland University of Technology, 46 Wakefield St, Auckland, 1010, New Zealand.

•Seedlings of New Zealand's treeline forming Fuscospora cliffortioides (Hook.f.) perform poorly beyond the established canopy, limiting treeline advance. Read More

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[Pathomorphological aspects of urethral strictures of various etiologies].

Urologiia 2021 May(2):5-13

Pirogov Russian National Research Medical University, Moscow, Russia.

Introduction: The study of the structure of strictures of various etiologies is an open and uncertain issue of modern urology.

Aim: To evaluate the morphological and immunohistochemical structure of strictures of various etiologies.

Materials And Methods: The study involved postoperative tissue of a pathologically altered urethra of 110 patients aged 23 to 74 years who underwent treatment at the University Clinic of Urology, Russian National Research Medical University. Read More

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Heart failure and atrial fibrillation: tachycardia-mediated acute decompensation.

ESC Heart Fail 2021 May 6. Epub 2021 May 6.

Cardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Gumiro 166, Bundang, Seongnam, Republic of Korea.

Aims: Tachycardia is a reversible event that may cause hemodynamic decompensation but may not necessarily cause direct damages to the myocardium. To evaluate the clinical outcomes of patients with heart failure (HF) and atrial fibrillation (AF), whose acute decompensation was tachycardia mediated.

Methods And Results: The Korean Acute Heart Failure registry was a prospective registry that consecutively enrolled 5625 patients with acute HF. Read More

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Tract-specific MRI measures explain learning and recall differences in multiple sclerosis.

Brain Commun 2021 1;3(2):fcab065. Epub 2021 Apr 1.

Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, CF24 4HQ, UK.

Cognitive difficulties are common and a key concern for people with multiple sclerosis. Advancing knowledge of the role of white matter pathology in multiple sclerosis-related cognitive impairment is essential as both occur early in the disease with implications for early intervention. Consequently, this cross-sectional study asked whether quantifying the relationships between lesions and specific white matter structures could better explain co-existing cognitive differences than whole brain imaging measures. Read More

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Evaluation of the merit of the methanolic extract of to supplement anti-snake venom in reversing secondary hemostatic abnormalities induced venom.

3 Biotech 2021 May 21;11(5):228. Epub 2021 Apr 21.

Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, Karnataka India.

Increasing evidence suggests a sizable involvement of hemotoxins in the morbidity associated with envenomation by the Indian spectacled cobra, (N.N). This study investigates the ability of Indian polyvalent anti-snake venom (ASV), methanolic extract of (MAP) and their combination in reversing the hemostatic abnormalities, viz. Read More

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Chromatin Modifiers in Transcriptional Regulation: New Findings and Prospects.

Acta Naturae 2021 Jan-Mar;13(1):16-30

Institute of Gene Biology RAS, Group of transcriptional complexes dynamics, Moscow, 119334 Russia.

Histone-modifying and remodeling complexes are considered the main coregulators that affect transcription by changing the chromatin structure. Coordinated action by these complexes is essential for the transcriptional activation of any eukaryotic gene. In this review, we discuss current trends in the study of histone modifiers and chromatin remodelers, including the functional impact of transcriptional proteins/ complexes i. Read More

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Anthracycline-containing carboplatin-containing neoadjuvant chemotherapy in combination with trastuzumab for HER2-positive breast cancer: the neoCARH phase II randomized clinical trial.

Ther Adv Med Oncol 2021 20;13:17588359211009003. Epub 2021 Apr 20.

Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No.123 Huifu West, Yuexiu District, Guangzhou, Guangdong 510080, China.

Background: Although dual blockade HER2-based neoadjuvant chemotherapy is associated with excellent outcomes for human epidermal growth factor receptor 2 (HER2)-positive breast cancer, pertuzumab is not available to all patients due to cost. The optimal neoadjuvant chemotherapy for HER2-positive breast cancer in the presence of a single HER2 blockade is unknown. This study aimed to compare the efficacy and safety of epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (EC-TH) with docetaxel/carboplatin/trastuzumab (TCH) neoadjuvant setting for HER2-positive breast cancer under the single HER2 blockade. Read More

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Therapeutic Effects and Associated Mechanisms by which "Fuyang Jiedu Huayu" Granules Treat Chronic Liver Failure in the Rat.

Evid Based Complement Alternat Med 2021 17;2021:7634673. Epub 2021 Apr 17.

The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, NanNing, GuangXi 530023, China.

Aim: Fuyang Jiedu Huayu (FYJDHY) granules are a combination of five traditional Chinese medicines with known therapeutic effects against chronic liver failure (CLF). The aim of the present study was to investigate the efficacy of FYJDHY to ameliorate the effects of carbon tetrachloride- (CCl4-) induced CLF in rats and to explore the possible molecular mechanisms underlying its therapeutic efficacy.

Methods: A model of chronic liver failure was established by intraperitoneal injection of 50% carbon tetrachloride into SD rats for 8 weeks. Read More

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Surgical stress and metabolic response after totally laparoscopic right colectomy.

Sci Rep 2021 May 6;11(1):9652. Epub 2021 May 6.

Department Clinical Medicine and Surgery, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

No clear consensus on the need to perform an intracorporeal anastomosis (IA) after laparoscopic right colectomy is currently available. One of the potential benefits of intracorporeal anastomosis may be a reduction in surgical stress. Herein, we evaluated the surgical stress response and the metabolic response in patients who underwent right colonic resection for colon cancer. Read More

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ATHB2 is a negative regulator of germination in Arabidopsis thaliana seeds.

Sci Rep 2021 May 6;11(1):9688. Epub 2021 May 6.

Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura (IFEVA), Facultad de Agronomía, Universidad de Buenos Aires, Av. San Martín 4453, C1417DSE, Buenos Aires, Argentina.

The germination timing of seeds is of the utmost adaptive importance for plant populations. Light is one of the best characterized factors promoting seed germination in several species. The germination is also finely regulated by changes in hormones levels, mainly those of gibberellin (GA) and abscisic acid (ABA). Read More

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Structures of the human Mediator and Mediator-bound preinitiation complex.

Science 2021 May 6. Epub 2021 May 6.

Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.

The 1.3-MDa transcription factor IID (TFIID) is required for preinitiation complex (PIC) assembly and RNA polymerase II (Pol II)-mediated transcription initiation on almost all genes. The 26-subunit Mediator stimulates transcription and cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of Pol II C-terminal domain (CTD). Read More

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Antiphospholipid antibodies in COVID-19: a meta-analysis and systematic review.

RMD Open 2021 May;7(2)

Department of Pulmonary/Critical Care, Wayne State University, Detroit, Michigan, USA

Background: Many studies reported high prevalence of antiphospholipid antibodies (aPL) in patients with COVID-19 raising questions about its true prevalence and its clinical impact on the disease course.

Methods: We conducted a meta-analysis and a systematic review to examine the prevalence of aPL and its clinical impact in patients with COVID-19.

Results: 21 studies with a total of 1159 patients were included in our meta-analysis. Read More

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Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.

Burns 2020 Dec 15. Epub 2020 Dec 15.

Fujian Provincial Key Laboratory of Burn and Trauma, Fujian Burn Institute, Fujian Burn Medical Center, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China. Electronic address:

Background: Patients with severe burns often show systemic coagulation changes in the early stage and even develop extensive coagulopathy. Previous studies have confirmed that soluble TREM-like transcript-1 (sTLT-1) mediates a novel mechanism of haemostasis and thrombosis in inflammatory vascular injury. At present, the role of sTLT-1 in patients with severe burns is not well known. Read More

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December 2020

Alpha 2-antiplasmin deficiency in a Sudanese child: a case report.

J Med Case Rep 2021 May 7;15(1):238. Epub 2021 May 7.

Hematology Department, Faculty of Medical Laboratory Sciences, Port Sudan Ahlia College, Port Sudan, Sudan.

Background: The plasma serine protease inhibitor alpha 2-antiplasmin (α-AP, otherwise known as α-plasmin inhibitor) is a rapid-acting plasmin inhibitor recently found in human plasma, which seems to have a significant role in the regulation of in vivo fibrinolysis. Congenital deficiency of α-AP is extremely uncommon.

Case Presentation: We report here a case of absolute deficiency of α-AP in an 11-year-old Sudanese boy, who had a lifelong intermittent hemorrhagic tendency (gum bleeding, epistaxis, and exaggerated bleeding after trauma). Read More

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Associations with thrombosis are stronger for antiphosphatidylserine/prothrombin antibodies than for the Sydney criteria antiphospholipid antibody tests in SLE.

Lupus 2021 May 6:9612033211014570. Epub 2021 May 6.

Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Objectives: Antiphosphatidylserine/prothrombin complex antibodies (aPS/PT) are risk factors for thrombosis, yet further validation of their clinical relevance in different ethnic groups is required. We investigated the performance of aPS/PT of IgA/G/M isotypes among Sudanese and Swedish systemic lupus erythematosus (SLE) patients.

Methods: Consecutive SLE patients/matched controls from Sudan (n = 91/102) and Sweden (n = 332/163) were included. Read More

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Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid.

ACS Appl Mater Interfaces 2021 May 7. Epub 2021 May 7.

Department of Microelectronic Science and Engineering, School of Physical Science and Technology, Ningbo University, Ningbo 315211, P. R. China.

Surface-enhanced Raman scattering (SERS) substrates based on graphene and its derivatives have recently attracted attention among those interested in the detection of trace molecules; however, these substrates generally show poor uniformity, an unsatisfactory enhancement factor, and require a complex fabrication process. Herein, we design and fabricate three-dimensional (3D) graphene/silicon (3D-Gr/Si) heterojunction SERS substrates to detect various types of molecules. Notably, the detection limit of 3D-Gr/Si can reach 10 M for rhodamine 6G (R6G) and rhodamine B (RB), 10 M for crystal violet (CRV), copper(II) phthalocyanine (CuPc), and methylene blue (MB), 10 M for dopamine (DA), 10 M for bovine serum albumin (BSA), and 10 M for melamine (Mel), which is superior to most reported graphene-based SERS substrates. Read More

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Effect of hyperparathyroidism on coagulation: A global assessment by modified rotation thromboelastogram (ROTEM).

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Objective: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium?s effects on parathyroid glands, bone, intestine and kidney, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Read More

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Determination of Mn(II) and Mn(VII) in beverage samples using magnetic dispersive micro-solid phase extraction coupled with solidified floating organic drop microextraction followed by graphite furnace atomic absorption spectrometry.

Food Chem 2021 Apr 28;359:129958. Epub 2021 Apr 28.

College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China.

Magnetic dispersive micro-solid phase extraction (MDMSPE) was coupled with solidified floating organic drop microextraction (SFODME) for direct separation and preconcentration of Mn(II) and Mn(VII) before graphite furnace atomic absorption spectrometry determination. MDMSPE involved use of magnetic ZnFeO nanotubes for adsorbing Mn(VII). Sorbent was isolated from aqueous phase by an external magnet. Read More

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