1,292 results match your criteria Facial Nerve Repair


Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits.

ACS Omega 2022 Jun 26;7(22):18509-18520. Epub 2022 May 26.

Department of Materials Science and Engineering, State Key Laboratory of New Ceramics and Fine Processing, Tsinghua University, Beijing 100084, China.

Facial nerve injury is a common clinical condition that leads to disfigurement and emotional distress in the affected individuals, and the recovery presents clinical challenges. Tissue engineering is the standard method to repair nerve defects. However, nerve regeneration is still not satisfactory because of poor neovascularization after implantation, especially for the long-segment nerve defects. Read More

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Treatment With Nimodipine or FK506 After Facial Nerve Repair Neither Improves Accuracy of Reinnervation Nor Recovery of Mimetic Function in Rats.

Front Neurosci 2022 13;16:895076. Epub 2022 May 13.

Department I of Anatomy, Faculty of Medicine, University of Cologne and University Hospital of Cologne, Cologne, Germany.

Purpose: Nimodipine and FK506 (Tacrolimus) are drugs that have been reported to accelerate peripheral nerve regeneration. We therefore tested these substances aiming to improve the final functional outcome of motoric reinnervation after facial nerve injury.

Methods: In 18 female rats, the transected facial nerve was repaired by an artificial nerve conduit. Read More

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Delivery of Basic Fibroblast Growth Factor Through an Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation the PAK-1 Signaling Pathway.

Front Pharmacol 2022 1;13:778680. Epub 2022 Apr 1.

Department of Otorhinolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Although studies have shown that basic fibroblast growth factor (bFGF) can activate autophagy and promote peripheral nerve repair, the role and the molecular mechanism of action of bFGF in the facial nerve are not clear. In this study, a thermosensitive forming poloxamer hydrogel was used as a vehicle to deliver bFGF for treating facial nerve injury (FNI) in the rat model. Using H&E and Masson's staining, we found that bFGF hydrogel can promote the functional recovery and regeneration of the facial nerve. Read More

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The Anatomic Landmark Approach to Extratemporal Facial Nerve Repair in Facial Trauma.

Cureus 2022 Mar 3;14(3):e22787. Epub 2022 Mar 3.

ENT - Facial Plastic Surgery, Albert Fox Facial Plastic Surgery Center, Dartmouth, USA.

Objective In this study, we aimed to examine the topical anatomic landmarks of the facial nerve (facial nerve areas) and their application in cases of extratemporal facial nerve injury in maxillofacial trauma. Materials and methods We analyzed 25 maxillofacial trauma patients with facial paralysis who underwent facial nerve reanimation surgery at the Ho Chi Minh City National Hospital of Odonto-Stomatology. The characteristics of each trauma case, including the mechanism of injury, the length of the facial injury, and the location/position of injury, were recorded. Read More

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Neurorrhaphy in Presence of Polyethylene Glycol Enables Immediate Electrophysiological Conduction in Porcine Model of Facial Nerve Injury.

Front Surg 2022 7;9:811544. Epub 2022 Mar 7.

Center for Brain Injury and Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Facial nerve trauma often leads to disfiguring facial muscle paralysis. Despite several promising advancements, facial nerve repair procedures often do not lead to complete functional recovery. Development of novel repair strategies requires testing in relevant preclinical models that replicate key clinical features. Read More

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Application of a strip design to monitor the viability of buried radial forearm free flap in East Asians: A case series study.

Auris Nasus Larynx 2022 Oct 20;49(5):862-867. Epub 2022 Mar 20.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University, Daehakro 101, Jongno-gu, Seoul 03080, South Korea. Electronic address:

Objectives: The objectives of this study were to evaluate the reliability of a strip design as a monitoring flap in buried flap and to investigate whether strip design of radial forearm free flap (RFFF) could affect donor site morbidity in East Asian.

Methods: Patients with externalized flap in buried RFFF were consecutively included in this study. For cases with mucosal defect repair, a skin strip with a 1. Read More

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October 2022

Stress relaxation and creep characteristics after treatment of chitosan/glycerophosphate-nerve growth factor hydrogel in facial nerve transplantation.

Asian J Surg 2022 05 10;45(5):1190-1191. Epub 2022 Mar 10.

Department of Stomatology, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, China. Electronic address:

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Age-related positivity effect of emotional attention: time and frequency domain.

Psychol Health Med 2022 Mar 8:1-12. Epub 2022 Mar 8.

Department of Biomedical Engineering, Chengde Medical University, Chengde, Hebei, China.

Compared with their younger counterparts, older adults are inclined to allocate more attentional resources to positive over negative materials. This age-related positivity effect has been reported in various experimental paradigms; however, studies have not investigated the attention stage at which it appears or its potential neural mechanism. Thus, we investigated the time and frequency domain dynamics of younger and older adults during emotional attention processes. Read More

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Overexpression of c-Jun inhibits erastin-induced ferroptosis in Schwann cells and promotes repair of facial nerve function.

J Cell Mol Med 2022 04 22;26(8):2191-2204. Epub 2022 Feb 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Myelin undergoes various changes after nerve injury, and c-Jun has a close relationship with Schwann cells (SCs). However, it remains unclear whether c-Jun can be involved in nerve repair by regulating ferroptosis. To explore this, we first set up a facial nerve injury model and detected the changes of ferroptosis-related proteins and c-Jun by immunofluorescence and Western blot. Read More

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Enhanced Recovery After Cleft Lip Repair: Protocol Development and Implementation in Outreach Settings.

Cleft Palate Craniofac J 2022 Feb 15:10556656221078744. Epub 2022 Feb 15.

Global Smile Foundation, Norwood, USA.

Introduction: Clefts of the lip are of the most common congenital craniofacial anomalies. The development and implementation of an enhanced recovery after surgery (ERAS) protocol among patients undergoing cleft lip repair may decrease postoperative complications, accelerate recovery, and result in earlier postoperative discharge.

Methods: A modified ERAS program was developed and applied through Global Smile Foundation outreach craniofacial programs. Read More

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February 2022

A Buccal Space Approach for Midface Free Flap Reconstruction.

Facial Plast Surg 2022 Apr 3;38(2):214-217. Epub 2022 Feb 3.

Department of Otorhinolaryngology & Head and Neck Surgery, Antwerp University Hospital, Antwerp, Belgium.

This article describes a transbuccal approach to reach the facial vessels. The anatomy of this intraoral approach is predictable, minimizing the risk of facial nerve dysfunction. This technique provides the possibility of free flap midface reconstruction with short pedicles and avoids the need to use vein grafts. Read More

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DHI Increases the Proliferation and Migration of Schwann Cells Through the PI3K/AKT Pathway and the Expression of CXCL12 and GDNF to Promote Facial Nerve Function Repair.

Neurochem Res 2022 May 26;47(5):1329-1340. Epub 2022 Jan 26.

Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The facial nerve is one of the vulnerable nerves in otolaryngology. Repair and recovery of facial nerve injury have a high priority in clinical practice. The proliferation and migration of Schwann cells are considered of great significance in the process of nerve injury repair. Read More

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Delayed Management of an Orbital Floor Blow-out Fracture.

Beyoglu Eye J 2021 27;6(3):249-253. Epub 2021 Sep 27.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Michigan, USA.

A bony fracture in the orbital floor, the most common site, can lead to tissue herniation, enophthalmos, hypoglobus, or strabismic diplopia. Several surgical approaches for repair have been described in the literature. This report is a description of an illustrative case and a brief summary of the literature related to the transconjunctival approach to orbital floor fracture repair as performed by ophthalmologists. Read More

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September 2021

Labelling stem cells with a nanoprobe for evaluating the homing behaviour in facial nerve injury repair.

Biomater Sci 2022 Feb 1;10(3):808-818. Epub 2022 Feb 1.

State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

It is crucial and clinically relevant to clarify the homing efficiency and retention of stem cells in different implanting strategies of cell therapy for various injuries. However, the need for a tool for investigating the mechanisms is still unmet. We herein introduce multi-modal BaGdF:Yb,Tm nanoparticles as a nanoprobe to label adipose-derived stem cells (ADSCs) and detect the homing behavior with a micro-computed tomography (micro-CT) imaging technique. Read More

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February 2022

LncRNA RMRP knockdown promotes proliferation and migration of Schwann cells by mediating the miR-766-5p/CAND1 axis.

Neurosci Lett 2022 01 30;770:136440. Epub 2021 Dec 30.

Department of Aesthetic Plastic & Craniofacial Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China. Electronic address:

The proliferation and migration of Schwann cells (SCs) promote nerve regeneration after facial nerve injury. In recent years, the role of long noncoding RNAs (lncRNAs) in regulating SC proliferation and migration has been gradually uncovered. However, there is little evidence on the function of lncRNA RMRP (lnc-RMRP) in SC growth. Read More

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January 2022

Muscle-Nerve-Nerve Grafting Improves Facial Reanimation in Rats Following Facial Nerve Injury.

Front Neurol 2021 8;12:723024. Epub 2021 Dec 8.

Department of Otolaryngology-Head and Neck Surgery, Loyola University of Chicago, Maywood, IL, United States.

Nerve injury resulting in muscle paralysis from trauma or surgery is a major medical problem. Repair of such injuries with existing nerve grafting and reconstructive techniques often results in less than optimal outcomes. After previously demonstrating significant return of function using muscle-nerve-muscle (MNM) grafting in a rat facial nerve model, this study compares a variant of the technique, muscle-nerve-nerve (MNN) neurotization to MNM and interposition (IP) nerve grafting. Read More

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December 2021

Aesthetic Repair of Unilateral Cleft Lip using the Modified Inferior Triangle and Adjunctive Techniques.

Plast Reconstr Surg 2022 Jan;149(1):70e-73e

From the Section of Plastic Surgery, Yale School of Medicine; and Division of Orthodontics, University of Connecticut.

Summary: Surgical management of unilateral cleft lip is challenging. Correction requires a comprehensive approach to ensure optimal aesthetic outcomes. Various techniques have been proposed for the repair of cleft lip. Read More

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January 2022

Effect of Cognitive Control on Age-Related Positivity Effects in Attentional Processing - Evidence From an Event-Related Brain Potential Study.

Front Psychol 2021 1;12:755635. Epub 2021 Dec 1.

Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

Studies investigating age-related positivity effects during facial emotion processing have yielded contradictory results. The present study aimed to elucidate the mechanisms of cognitive control during attentional processing of emotional faces among older adults. We used go/no-go detection tasks combined with event-related potentials and source localization to examine the effects of response inhibition on age-related positivity effects. Read More

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December 2021

The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis.

Front Cell Neurosci 2021 25;15:764141. Epub 2021 Nov 25.

Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education, Division of Spine Surgery, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Trigeminal neuralgia (TN) is a severe chronic neuropathic pain. Despite numerous available medical interventions, the therapeutic effects are not ideal. To control the pain attacks, the need for more contemporary drugs continues to be a real challenge. Read More

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November 2021

[Clinical analysis of 32 cases of facial nerve schwannomas].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Dec;35(12):1085-1091

Department of Otolaryngology,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou,510120,China.

To elucidate the clinical characteristics, surgical strategy, facial nerve repair methods and outcomes of facial nerve schwannomas(FNS). The clinical data of patients with FNS treated between January 2010 and December 2018 at Sun Yat-sen Memorial Hospital of Sun Yat-sen University were retrospectively collected, including the sidedness of FNS, clinical manifestations, imaging data, the extent of tumor, clinical management, preoperative and postoperative facial nerve function. The major clinical manifestations of the 32 patients with FNS were facial palsy(27, 84. Read More

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December 2021

Partial parotid sialoadenectomy in a horse with parotid ductal carcinoma: Surgical description and case report.

Vet Surg 2022 Feb 1;51(2):296-302. Epub 2021 Dec 1.

Auburn University, Auburn, Alabama, USA.

Objectives: To describe the surgical findings, histopathological features, and long-term outcome for a horse with parotid salivary carcinoma.

Study Design: Case report ANIMALS: Twelve year old American Quarter Horse gelding.

Methods: The gelding was presented for a 10 × 10 cm swelling below the base of the right ear. Read More

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February 2022

Controlled release of ciliary neurotrophic factor from bioactive nerve grafts promotes nerve regeneration in rats with facial nerve injuries.

J Biomed Mater Res A 2022 04 18;110(4):788-796. Epub 2021 Nov 18.

Department of Neurosurgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

It is critical to repair severed facial nerves, as lack of treatment may cause long-term motor and sensory impairments. Ciliary neurotrophic factor (CNTF) plays an important role in terms of enhancing nerve axon regrowth and maturation during peripheral nerve regeneration after injury. However, simple application of CNTF to the transected nerve site does not afford functional recovery, because it is rapidly flushed away by bodily fluids. Read More

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Complete Facial Paralysis Caused by Stabbing With a Car Key at the Stylomastoid Foramen.

Ear Nose Throat J 2021 Nov 18:1455613211056548. Epub 2021 Nov 18.

Department of Otolaryngology Head and Neck Surgery, 159407The First Affiliated Hospital of China Medical University, Shenyang, China.

Non-iatrogenic traumatic facial paralysis is most common in intratemporal facial nerve injury caused by temporal bone fracture, followed by intraparotid facial nerve branch injury. Facial paralysis caused by injury to the extratemporal trunk of the facial nerve is extremely rare. We present a case of a 60-year-old man suffering from immediate complete left peripheral facial paralysis due to blunt transection of extratemporal trunk of facial nerve by stabbing with a car key. Read More

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November 2021

The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers.

PLoS Pathog 2021 11 15;17(11):e1010033. Epub 2021 Nov 15.

School of Biological Sciences, University of Southampton, Southampton, United Kingdom.

Contagious cancers are a rare pathogenic phenomenon in which cancer cells gain the ability to spread between genetically distinct hosts. Nine examples have been identified across marine bivalves, dogs and Tasmanian devils, but the Tasmanian devil is the only mammalian species known to have given rise to two distinct lineages of contagious cancer, termed Devil Facial Tumour 1 (DFT1) and 2 (DFT2). Remarkably, DFT1 and DFT2 arose independently from the same cell type, a Schwann cell, and while their ultra-structural features are highly similar they exhibit variation in their mutational signatures and infection dynamics. Read More

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November 2021

An Anatomical Feasibility Study on the Use of the Hypoglossal and Hemihypoglossal Nerve as a Donor Motor Nerve for Free Functioning Muscle Transfer in Upper Extremity Reconstruction.

J Hand Surg Am 2021 Nov 11. Epub 2021 Nov 11.

Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital, Stony Brook Medicine, Stony Brook, NY; Department of Orthopaedic Surgery, Stony Brook University Hospital, Stony Brook Medicine, Stony Brook, NY. Electronic address:

Purpose: Brachial plexus injuries (BPI) with complete root avulsions remains a clinical challenge due to a paucity of nerves available for nerve transfer and innervation of free functioning muscle transfers (FFMT). The hypoglossal and hemihypoglossal nerve has not been studied as a donor nerve option for FFMTs in brachial plexus reconstruction, despite successful outcomes of hypoglossal nerve transfers in facial reanimation surgery. We hypothesized that the hypoglossal nerve could be an appropriate candidate for surgical repair of BPI using FFMT. Read More

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November 2021

The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity.

Hum Mol Genet 2022 04;31(8):1242-1262

Laboratory for Regeneration of Sensorimotor Systems, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef 47, Amsterdam 1105BA, The Netherlands.

The regeneration-associated gene (RAG) expression program is activated in injured peripheral neurons after axotomy and enables long-distance axon re-growth. Over 1000 genes are regulated, and many transcription factors are upregulated or activated as part of this response. However, a detailed picture of how RAG expression is regulated is lacking. Read More

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The Supraorbital Approach via an Eyebrow Incision: Analysis of Cosmetic Outcomes Using the Scar Cosmesis Assessment Rating Scale.

J Craniofac Surg 2022 Jan-Feb 01;33(1):307-311

Facial Plastic & Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA.

Abstract: The supraorbital craniotomy through an eyebrow incision, referred to as the suprabrow approach, may be used to access intracranial lesions. Though offering good surgical exposure for anterior base cranial lesions, the suprabrow approach has a paucity of studies on its cosmetic outcomes. In this study, we aimed to assess the cosmetic outcomes of suprabrow approach using validated Scar Cosmesis Assessment Rating (SCAR) scale for the first time. Read More

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January 2022

Facial Nerve Reconstruction Using Acellular Nerve Allograft.

J Craniofac Surg 2021 Oct 22. Epub 2021 Oct 22.

Department of Cosmetic and Plastic Surgery, Carolinas Medical Center, Charlotte, NC.

Abstract: When repaired with interposition nerve grafts, segmental facial nerve defects are traditionally treated with nerve autograft. The authors present a patient who presented after partial resection of a basal cell carcinoma over the left zygomatic region with positive deep and peripheral margins and complete loss of frontal and zygomatic facial nerve function. She was subsequently treated with wide resection, superficial parotidectomy, and cervicofacial flap. Read More

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October 2021

Bilateral Nervus Intermedius Sectioning for Geniculate Neuralgia: Case Report and Operative Video.

Oper Neurosurg (Hagerstown) 2021 11;21(6):E566-E568

Department of Neurosurgery and Brain Repair, Morsani College of Medicine, Tampa General Hospital, University of South Florida, Tampa, Florida, USA.

Background And Importance: Geniculate neuralgia is a rare condition characterized by excruciating ear pain. Surgical options for geniculate neuralgia include microvascular decompression and sectioning of the nervus intermedius. We report herein a case of bilateral geniculate neuralgia treated by nervus intermedius sectioning without prior microvascular decompression. Read More

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November 2021

Direct Neurotization: Past, Present, and Future Considerations.

Ann Plast Surg 2022 03;88(3):308-312

Department of Plastic Surgery, University of Tennessee Health Science Center (UTHSC), Memphis, TN.

Abstract: Direct neurotization is a method that involves direct implantation of nerve fascicles into a target tissue, that is, muscle fibers, skin, cornea, and so on, with the goal of restoring aesthetic, sensation and or functional capacity. This technique has been implemented since the early 1900s, with numerous experimental and clinical reports of success. Applications have included both sensory and motor neurotization of muscle, as well as protective sensory provision for other organs. Read More

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