1,581 results match your criteria Facial Nerve Embryology


Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair.

Muscle Nerve 2020 Jun 4. Epub 2020 Jun 4.

Department of Anatomy I, University of Cologne, Germany.

Introduction: After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono-innervated neuro-muscular junctions (NMJ). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ-mono-innervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor-2 (FGF2) and brain derived neurotrophic factor (BDNF) in denervated vibrissal muscles.

Methods: We used normally-sighted rats (Wistar), in which NMJ-poly-innervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti-BDNF and FGF2 at different postoperative periods after facial nerve injury. Read More

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http://dx.doi.org/10.1002/mus.26991DOI Listing

Magnetic Resonance Imaging Surveillance for Vestibular Schwannoma After Microsurgical Resection Using a Retrosigmoid Transmeatal Approach.

World Neurosurg 2020 May 1. Epub 2020 May 1.

Department of Neurosurgery, Hospital Clínico Universitario de Valencia, Valencia, Spain; Microneurosurgery Laboratory, Department of Anatomy and Human Embryology, Universitat de Valencia, Valencia, Spain; INCLIVA Instituto de Investigación Sanitaria, Valencia, Spain.

Background: Vestibular schwannoma (VS) is a benign, usually slow-growing tumor. The drawback of radical microsurgical VS resection is the increased likelihood of neurologic injury, forcing surgeons to leave a tumor remnant in some cases. We evaluated the prognostic value of magnetic resonance imaging (MRI) enhancement patterns to determine the risk of tumor regrowth. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.073DOI Listing

Gross Anatomical, Radiographic and Doppler Sonographic Approach to the Infra-auricular Parotid Region in Donkey (Equus asinus).

J Equine Vet Sci 2020 May 29;88:102968. Epub 2020 Feb 29.

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

The present study was performed on 12 heads of donkey's cadavers of both sexes for different anatomic techniques and on 20 live adult donkeys for ultrasonographic approaches of local anesthetic techniques. The aim was to achieve safe desensitization of the ear canal and tympanic membrane in addition to measuring different parameters of the structures occupying the infra-auricular parotid region. The internal auricular nerve was divided into two fine branches and constituting, at its origin, a characteristic V-shape with the caudal auricular nerve. Read More

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http://dx.doi.org/10.1016/j.jevs.2020.102968DOI Listing
May 2020
0.871 Impact Factor

The efficiency of ozone therapy and low-level laser therapy in rat facial nerve injury.

J Craniomaxillofac Surg 2020 Mar 3;48(3):308-314. Epub 2020 Feb 3.

Bezmialem Vakif University Dentistry Faculty, Oral and Maxillofacial Surgery Department, Istanbul, Turkey. Electronic address:

Purpose: Comparison of low-level laser therapy (LLLT) and ozone therapy (OT) methods for the treatment of facial nerve injury (FNI) in rats, evaluated by histomorphometric measurement analysis.

Materials And Methods: Thirty rats were randomly divided into control (C), LLLT, and OT groups. The left facial nerves (FNs) of all rats (n = 30) were used in this study. Read More

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http://dx.doi.org/10.1016/j.jcms.2020.01.017DOI Listing

The Developmental Origin of the Auricula Revisited.

Laryngoscope 2019 Dec 11. Epub 2019 Dec 11.

and Department of Medical Biology, Section Clinical Anatomy and Embryology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Objectives/hypothesis: Congenital auricular anomalies are common. Additionally, the auricle plays an important role in the staging of human embryos. However, little is known about the embryological development of the auricle. Read More

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http://dx.doi.org/10.1002/lary.28456DOI Listing
December 2019

[A 4-year-old girl with a recurrent infection in the neck: a familiar picture with a rare cause].

Ned Tijdschr Geneeskd 2019 10 24;163. Epub 2019 Oct 24.

Amsterdam Universitair Medisch Centrum, locatie VUmc, Afd. KNO-hoofd-halschirurgie, Amsterdam.

Background: Infections of the neck are frequently seen in young children and are usually harmless and transient. In the case of atypical symptoms, however, it is important to be alert to the possibility of less common causes requiring specific treatment.

Case Description: A 4-year-old girl was seen in the outpatient clinic with a recurrent, inflamed swelling in the neck. Read More

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October 2019

Bacterial cellulose tubes as a nerve conduit for repairing complete facial nerve transection in a rat model.

Eur Arch Otorhinolaryngol 2020 Jan 8;277(1):277-283. Epub 2019 Oct 8.

Department of Otorhinolaryngology-Head and Neck Surgery, Pendik Training and Research Hospital, Marmara University Medical Faculty, Istanbul, Turkey.

Purpose: Functionality of the facial nerve is cosmetically important. While many techniques have been investigated, early and effective treatment for traumatic facial nerve paralysis remains challenging. Here, we aim to examine bacterial cellulose (BC) as a new tubularization material for improving facial nerve regeneration. Read More

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http://dx.doi.org/10.1007/s00405-019-05637-9DOI Listing
January 2020
1 Read

An Anatomic Variant of the Ansa Cervicalis Precluding Its Use as a Donor Nerve.

Ann Otol Rhinol Laryngol 2020 Jan 11;129(1):78-81. Epub 2019 Sep 11.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Background: The ansa cervicalis is useful for cranial nerve repair, and may be harvested without apparent morbidity. Herein we report an unusual and surgically relevant anatomic variant of the ansa cervicalis.

Methods: An adult male with left parotid adenoid cystic carcinoma underwent parotidectomy with upper-division facial nerve resection and planned interposition repair using the ansa cervicalis. Read More

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http://dx.doi.org/10.1177/0003489419875975DOI Listing
January 2020
2 Reads

Bifid Facial Nerve with Dual Origin Identified During Resection of Vestibular Schwannoma.

World Neurosurg 2019 Dec 4;132:375-376. Epub 2019 Sep 4.

Department of Surgery, Monash University, Melbourne, Victoria, Australia; Department of Otolaryngology, Alfred Hospital, Melbourne, Victoria, Australia.

Facial nerve identification and preservation is a critical step in the resection of vestibular schwannoma. The use of intraoperative neurostimulation to positively identify the facial nerve along its entire course is essential to prevent injury. To our knowledge, this is the first reported case of a bifid facial nerve with a dual origin at the brainstem, which we observed during resection of vestibular schwannoma via the translabyrinthine approach. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.213DOI Listing
December 2019
1 Read

Histopathology of Inner Ear Malformations: Potential Pitfalls for Cochlear Implantation.

Otol Neurotol 2019 09;40(8):e839-e846

Department of Otolaryngology, Head and Neck Surgery, University of Minnesota - Minneapolis, Minnesota, USA.

Hypothesis: The presence of bony inner ear malformations may associate with a number of anatomical abnormalities affecting the middle ear structures. Those malformations may create pitfalls and complications for cochlear implantation.

Background: Inner ear malformations associate with varying degrees of hearing loss, and frequently require cochlear implantation for hearing rehabilitation. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002356DOI Listing
September 2019
2 Reads

Trigeminal Aδ- and C-afferent supply of lamina I neurons in the trigeminocervical complex.

Pain 2019 11;160(11):2612-2623

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

Nociceptive trigeminal afferents innervating craniofacial area, eg, facial skin and cranial meninges, project to a broad region in the medullary and upper cervical dorsal horn designated as the trigeminocervical complex. Lamina I neurons in the trigeminocervical complex integrate and relay peripheral inputs, thus playing a key role in both cranial nociception and primary headache syndromes. Because of the technically challenging nature of recording, the long-range trigeminal afferent inputs to the medullary and cervical lamina I neurons were not intensively studied so far. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001659DOI Listing
November 2019
6 Reads

[Congenital middle ear malformation: clinical analysis and discussion of classification].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jul;54(7):481-488

Department of Otorhinolaryngology Head and Neck Surgery, the Sixth Medical Center of People's Liberation Army General Hospital, Beijing 100048, China.

To analyze the clinical characteristics and appropriate surgical procedures, and discuss the classification of congenital middle ear malformation. All cases were from the Center of Otorhinolaryngology, the Sixth Medical Center of Department of PLA General Hospital. All of these cases, including 26 male patients (ears) , 10 female patients (11 ears) , aged from 7 to 57 years old, had normal external auditory canal, tympanic membrane, conductive hearing loss, type A tympanogram and negative Gelle's test. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.07.001DOI Listing
July 2019
6 Reads

Cochlear Nerve Hypoplasia: Audiological Characteristics in Children and Adults.

Audiol Neurootol 2019 15;24(3):147-153. Epub 2019 Jul 15.

Department of Ear, Nose and Throat, Hacettepe University, Ankara, Turkey.

Background: Cochlear nerve deficiency is a general term used to describe both cochlear nerve hypoplasia (CNH) and cochlear nerve aplasia. Although these two conditions can have similar results on audiological evaluation, CNH yields more variation in audiological tests.

Objectives: To describe the audiological characteristics of the CNH cases in our series in relation to radiological findings. Read More

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http://dx.doi.org/10.1159/000500938DOI Listing

Facial Nerve Duplication and First Branchial Cleft Cysts: An Association in an Uncommon Pathology.

Otolaryngol Head Neck Surg 2019 11 2;161(5):904-905. Epub 2019 Jul 2.

Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1177/0194599819861341DOI Listing
November 2019
8 Reads

Endoscopic-Assisted Cochlear Implantation in Children with Malformed Ears.

Otolaryngol Head Neck Surg 2019 10 4;161(4):688-693. Epub 2019 Jun 4.

ENT Department, University Hospital of Verona, Verona, Italy.

Objective: Complex middle and inner ear malformations are considered an important limitation for cochlear implant (CI) with traditional microscopic techniques. The aim of the present study is to describe the results of the endoscopic-assisted CI procedure in children with malformed ears.

Study Design: Case series with chart review of consecutive patients. Read More

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http://dx.doi.org/10.1177/0194599819844493DOI Listing
October 2019
15 Reads

A rare case of unilateral hemifacial spasm and facial palsy associated with an abnormal anatomical variant of the posterior basilar circulation.

Ann R Coll Surg Engl 2019 Jul 3;101(6):e1-e3. Epub 2019 Jun 3.

Department of Otolaryngology, Princess Royal Hospital, Shrewsbury and Telford Hospital NHS Trust , Telford , UK.

Tortuous vertebral arteries are a rare anatomical variant. Mild tortuosity is usually asymptomatic whereas severe tortuosity may present with ischaemic symptoms or compressive symptoms (focal neurological deficit). While a resulting hemifacial spasm has been previously described, sparse literature exists for its association with facial palsy. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554565PMC
July 2019
9 Reads

A Salivation Abnormality with Trigeminal Nerve Dysfunction in Dogs.

J Vet Dent 2019 Mar;36(1):8-16

3 Section of Anatomic Pathology, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

Trigeminal nerve pathology can lead to sensory and motor dysfunction to structures of the head that are easily recognized. The trigeminal nerve is a conduit for the distribution of postganglionic parasympathetic innervation to structures of the head. Parasympathetic innervation to the salivary glands is provided by preganglionic parasympathetic neurons of the facial and glossopharyngeal nerves. Read More

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http://dx.doi.org/10.1177/0898756419846607DOI Listing
March 2019
13 Reads

Case 266: Pontine Tegmental Cap Dysplasia.

Radiology 2019 06;291(3):814-818

From the Departments of Radiology (C.J.C., C.M.) and Otorhinolaryngology (L.F.), University Hospital Crosshouse, Kilmarnock, Scotland.

History A 1-year-old boy was referred for cochlear implant assessment after he received a diagnosis of bilateral profound sensorineural hearing loss at neonatal hearing screening shortly after birth. The child was born at term via uneventful delivery, and there was no history of familial hearing loss or maternal illness. Tympanic membranes were normal, and hearing loss was confirmed with auditory brainstem testing, which showed no response from either ear. Read More

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http://dx.doi.org/10.1148/radiol.2018162304DOI Listing
June 2019
3 Reads

Unilateral facial nerve hypoplasia without evident facial palsy.

BMJ Case Rep 2019 May 13;12(5). Epub 2019 May 13.

Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

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http://dx.doi.org/10.1136/bcr-2018-228036DOI Listing
May 2019
2 Reads

Differences in management outcome for first branchial cleft anomalies: A comparison of infants and toddlers to older children.

Int J Pediatr Otorhinolaryngol 2019 Jul 11;122:161-164. Epub 2019 Apr 11.

Division of Pediatric Otolaryngology Head and Neck Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Department of Otolaryngology, McGaw Medical Center of Northwestern University, Chicago, IL, USA.

Objective: First branchial cleft anomalies (FBCAs) are rare and often misdiagnosed, which can delay proper management and increase surgical risks. Complete excision often requires parotidectomy with facial nerve dissection. The literature reports that younger patients more often have lesions deep to the nerve with higher rates of nerve injury. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.009DOI Listing
July 2019
6 Reads

Effect of surgically guided axonal regrowth into a 3-way-conduit (isogeneic trifurcated aorta) on functional recovery after facial-nerve reconstruction: Experimental study in rats.

Restor Neurol Neurosci 2019 ;37(2):181-196

Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Background: The "post-paralytic syndrome" after facial nerve reconstruction has been attributed to (i) malfunctioning axonal guidance at the fascicular (branches) level, (ii) collateral branching of the transected axons at the lesion site, and (iii) intensive intramuscular terminal sprouting of regenerating axons which causes poly-innervation of the neuromuscular junctions (NMJ).

Objective: The first two reasons were approached by an innovative technique which should provide the re-growing axons optimal conditions to elongate and selectively re-innervate their original muscle groups.

Methods: The transected facial nerve trunk was inserted into a 3-way-conduit (from isogeneic rat abdominal aorta) which should "guide" the re-growing facial axons to the three main branches of the facial nerve (zygomatic, buccal and marginal mandibular). Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/RNN-190899DOI Listing
July 2019
27 Reads

CT Imaging Categorization and Biomarker Study of Anomalous Tympanic Segment of the Facial Nerves in Patients With Hearing Loss in the Absence of Microtia.

Ear Nose Throat J 2019 Jul 8;98(6):340-345. Epub 2019 Apr 8.

1 Department of Radiology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.

The purpose of this study is to categorize anomalous tympanic facial nerve (FN) on high-resolution computed tomography (HRCT) and to determinate the significance of associated temporal bone anomalies and congenital syndromes without microtia in patients with hearing loss. A retrospective analysis of HRCT findings in 30 temporal bones in 18 patients with anomalous FN was performed. Abnormalities of the tympanic FN were categorized as follows: category 1: FN medially positioned, but above the oval window; category 2: FN in the oval window niche; and category 3: FN below the oval window. Read More

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http://dx.doi.org/10.1177/0145561319839899DOI Listing

Experimental Studies on Facial Nerve Regeneration.

Anat Rec (Hoboken) 2019 08 17;302(8):1287-1303. Epub 2019 Apr 17.

Department of Anatomy 1, University of Cologne, Cologne, Germany.

Insufficient recovery after injury of a peripheral motor nerve is due to (1) inappropriate pathfinding as a result of axonal regrowth to inappropriate targets, (2) excessive collateral axonal branching at the lesion site, and (3) polyinnervation of the neuromuscular junctions (NMJs). The rat facial nerve model is often used because of its simple and reliable readout to measure recovery of function (vibrissal whisking). Over the last decades scientists have concentrated their efforts to combat mostly NMJ polyinnervation, because it turned out to be very difficult to reduce collateral axonal branching and impossible to navigate thousands of axons toward the original fascicles. Read More

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http://dx.doi.org/10.1002/ar.24123DOI Listing
August 2019
20 Reads

Functional genomics analysis of Phelan-McDermid syndrome 22q13 region during human neurodevelopment.

PLoS One 2019 15;14(3):e0213921. Epub 2019 Mar 15.

Division of Intramural Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.

Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by varying degrees of intellectual disability, severely delayed language development and specific facial features, and is caused by a deletion within chromosome 22q13.3. SHANK3, which is located at the terminal end of this region, has been repeatedly implicated in other neurodevelopmental disorders and deletion of this gene specifically is thought to cause much of the neurologic symptoms characteristic of PMS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213921PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420160PMC
December 2019
1 Read

Pediatric Stapes Surgery: Hearing and Surgical Outcomes in Endoscopic vs Microscopic Approaches.

Otolaryngol Head Neck Surg 2019 07 12;161(1):150-156. Epub 2019 Mar 12.

1 Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Objective: To compare endoscopic and microscopic pediatric stapes surgery.

Study Design: Case series with chart review.

Setting: Two academic otology practices. Read More

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http://dx.doi.org/10.1177/0194599819836679DOI Listing
July 2019
18 Reads

Trigeminal Neuralgia Due to Petrosal Bone Deformity.

World Neurosurg 2019 06 1;126:79-82. Epub 2019 Mar 1.

Department of Neurosurgery, Saitama Medical University Hospital, Saitama, Japan.

Background: There have been a few previous reports of trigeminal neuralgia caused by bony structures. We report a rare case of trigeminal neuralgia caused by petrous bone deformity.

Case Description: A-43-year-old man with facial pain in the left maxillary and mandibular divisions of the trigeminal nerve was referred to our hospital. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.114DOI Listing

Anatomical study of the masseteric and obturator nerves: Application to face transplant and reanimation procedures.

Clin Anat 2019 Jul 4;32(5):612-617. Epub 2019 Apr 4.

Department of Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain.

The masseteric nerve (MN) and the anterior branch of the obturator nerve (ON) that innervate the transferred gracilis muscle have proved highly efficient for reanimating paralyzed facial muscles when muscle transfer is required. Previous researchers have published the total axonal load for myelinated fibers in both nerves. However, the real motor axonal load has not been established. Read More

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http://dx.doi.org/10.1002/ca.23357DOI Listing
July 2019
10 Reads

Unusual and multiple variations of head and neck veins: a case report.

Surg Radiol Anat 2019 May 18;41(5):535-538. Epub 2019 Feb 18.

Department of Anatomy, JIPMER, Puducherry, India.

We report an unusual and multiple variation involving the right head and neck veins which were found during routine dissection in a 50-year-old male cadaver, facial vein draining into both external and internal jugular veins, fenestration in external jugular vein transmitting the supraclavicular nerve trunk, the anterior division of the retromandibular vein draining into anterior jugular vein and the absence of the common facial vein. The knowledge about these variations is important during various surgical and diagnostic procedures involving head and neck region. Read More

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http://dx.doi.org/10.1007/s00276-019-02203-0DOI Listing
May 2019
4 Reads

Vertebral anomalies in craniofacial microsomia: a retrospective analysis of 991 patients.

Int J Oral Maxillofac Surg 2018 Nov 22;47(11):1365-1372. Epub 2018 Jun 22.

Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, USA.

Craniofacial microsomia (CFM) is characterized by an underdevelopment of the facial structures arising from the first and second branchial arches, but extracraniofacial anomalies such as vertebral anomalies may be present. This retrospective study was performed to determine the prevalence and types of vertebral anomalies and the association with other extracraniofacial anomalies in patients with CFM. The charts of all patients diagnosed with CFM seen in four craniofacial centres were reviewed for the presence of vertebral anomalies, symptoms, extracraniofacial anomalies, and the OMENS classification including the Pruzansky-Kaban type of mandibular deformity. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.05.016DOI Listing
November 2018
11 Reads

TrkB expression and dependence divides gustatory neurons into three subpopulations.

Neural Dev 2019 01 28;14(1). Epub 2019 Jan 28.

Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 511 S. Floyd St., MDR Building Room 111, Louisville, KY, 40202, USA.

Background: During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate it. Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor brain derived neurotrophic factor (BDNF). Read More

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http://dx.doi.org/10.1186/s13064-019-0127-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350382PMC
January 2019
6 Reads
3.453 Impact Factor

Robo1 and 2 Repellent Receptors Cooperate to Guide Facial Neuron Cell Migration and Axon Projections in the Embryonic Mouse Hindbrain.

Neuroscience 2019 03 24;402:116-129. Epub 2019 Jan 24.

Department of Biology, University of Nevada, 1664 N Virginia St, Reno, NV 89557, USA. Electronic address:

The facial nerve is necessary for our ability to eat, speak, and make facial expressions. Both the axons and cell bodies of the facial nerve undergo a complex embryonic developmental pattern involving migration of the cell bodies caudally and tangentially through rhombomeres, and simultaneously the axons projecting to exit the hindbrain to form the facial nerve. Our goal in this study was to test the functions of the chemorepulsive receptors Robo1 and Robo2 in facial neuron migration and axon projection by analyzing genetically marked motor neurons in double-mutant mouse embryos through the migration time course, E10. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435285PMC
March 2019
3 Reads

The emerging role of cranial nerves in shaping craniofacial development.

Genesis 2019 01;57(1):e23282

Program in Craniofacial Biology, Department of Cell and Tissue Biology, University of California, San Francisco, California.

Organs and structures of the vertebrate head perform a plethora of tasks including visualization, digestion, vocalization/communication, auditory functions, and respiration in response to neuronal input. This input is primarily derived from afferent and efferent fibers of the cranial nerves (sensory and motor respectively) and efferent fibers of the cervical sympathetic trunk. Despite their essential contribution to the function and integration of processes necessary for survival, how organ innervation is established remains poorly understood. Read More

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http://dx.doi.org/10.1002/dvg.23282DOI Listing
January 2019
9 Reads

Two synchronous congenital neck masses with facial nerve weakness.

Int J Pediatr Otorhinolaryngol 2019 Feb 31;117:45-47. Epub 2018 Oct 31.

Ann & Robert H. Lurie Children's Hospital of Chicago, USA; Northwestern University, Feinberg School of Medicine, USA.

Objective: To describe a case of a complex neck mass with final pathology significant for two synchronous lesions, a type 1 branchial cleft cyst and an enteric duplication cyst, and to discuss its management given the unique presentation. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.10.041DOI Listing
February 2019
8 Reads

Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy.

J Int Adv Otol 2019 Apr;15(1):43-50

Department of Neurology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

Objectives: To investigate the effects of topical and systemic administrations of melatonin and dexamethasone on facial nerve regeneration.

Materials And Methods: In total, 50 male albino Wistar rats underwent facial nerve axotomy and neurorrhaphy. The animals were divided into 5 groups: control, topical melatonin, systemic melatonin, topical dexamethasone, and systemic dexamethasone. Read More

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http://dx.doi.org/10.5152/iao.2018.3273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483441PMC
April 2019
10 Reads

Fetal anatomy of the facial nerve trunk and its relationship with posterior auricular artery.

Surg Radiol Anat 2019 Feb 26;41(2):153-159. Epub 2018 Oct 26.

Department of Anatomy, Faculty of Medicine, Mersin University, Mersin, Turkey.

Purpose: The aims of the study are to define anatomy of the facial nerve (FN) and its main trunks as well as their relationship with the posterior auricular artery in fetal period to evaluate the data for regional surgery in newborns and young infants.

Methods: Formalin-fixed 34 fetuses from anatomy laboratory collection with a mean gestational age of 26.4 ± 4. Read More

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http://dx.doi.org/10.1007/s00276-018-2126-xDOI Listing
February 2019
18 Reads

Pediatric glossopharyngeal neuralgia: a comprehensive review.

Childs Nerv Syst 2019 03 25;35(3):395-402. Epub 2018 Oct 25.

Department of Anatomical Sciences, St. George's University, St. George, Grenada.

Introduction: Debilitating facial pain can seriously affect an individual's daily living. Given that the pathophysiology behind neuropathic and myofascial pain is not fully understood, when chronic facial pain goes undiagnosed, it has been proposed that one of the two is the likely cause. Since their discovery, glossopharyngeal neuralgia (GN) and Eagle's syndrome have been considered mostly conditions afflicting the adult population. Read More

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http://link.springer.com/10.1007/s00381-018-3995-3
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http://dx.doi.org/10.1007/s00381-018-3995-3DOI Listing
March 2019
31 Reads

Analysis of inner ear malformations associated with a facial nerve anomaly in 653 children fitted with a cochlear implant.

Clin Otolaryngol 2019 01 18;44(1):96-101. Epub 2018 Nov 18.

Service d'ORL Pédiatrique, Hôpital Femme Mère Enfants, Centre Hospitalier et Universitaire, Lyon, France.

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http://dx.doi.org/10.1111/coa.13246DOI Listing
January 2019

Dental malocclusion stimulates neuromuscular circuits associated with temporomandibular disorders.

Eur J Oral Sci 2018 12 20;126(6):466-475. Epub 2018 Oct 20.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Unilateral anterior crossbite (UAC) has been demonstrated to cause masseter hyperactivity via the periodontal trigeminal mesencephalic nucleus (Vme)-trigeminal motor nucleus circuit. Here, we studied activation of motor neurons of the facial nucleus (VII), hypoglossal nucleus (XII), nucleus ambiguus (Amb), and spinal nucleus of the accessory nerve (SNA) in rats with UAC via their similar connections with Vme. An anterograde tracer, biotinylated dextran amine (BDA), was injected into the Vme to identify the central axon terminals around the motor neurons of VII, XII, Amb, and SNA. Read More

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http://dx.doi.org/10.1111/eos.12579DOI Listing
December 2018
14 Reads

Surgical Management for Dysplastic or Congenitally Absent Oval Window.

Otol Neurotol 2018 12;39(10):e1039-e1046

Otolaryngology/Facial Plastic Reconstructive Surgery, Farragut ENT and Allergy, Knoxville, Tennessee.

Objective: To evaluate surgical findings and hearing results for patient's undergoing the described surgical approach for congenitally absent or dysplastic oval window (OW).

Study Design: The Institutional Review Board approved retrospective review of patients with conductive hearing loss (CHL) operated on from 1992 to 2016.

Setting: Academic tertiary center. Read More

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http://Insights.ovid.com/crossref?an=00129492-900000000-9659
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http://dx.doi.org/10.1097/MAO.0000000000002001DOI Listing
December 2018
4 Reads

MR Neurographic Evaluation of Facial and Neck Pain: Normal and Abnormal Craniospinal Nerves below the Skull Base.

Radiographics 2018 Sep-Oct;38(5):1498-1513

From the Departments of Radiology (A.C., R.S.Q., J.W.), Orthopaedic Surgery (A.C.), Neurological Surgery (J.W.), Otolaryngology (L.L.M.), Plastic Surgery (B.A.), Surgery (J.R.Z.), and Neurology and Neurotherapeutics (J.R.Z.), University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9178; and Department of Diagnostic Radiology, University of Arkansas for Medical Sciences, Little Rock, Ark (G.B., V.W.).

Cranial nerve disease outside the skull base is a common cause of facial and/or neck pain, which causes significant disability for patients and frustration for clinicians. Neuropathy in this region can be traumatic, idiopathic, or iatrogenic secondary to dental and surgical procedures. MR neurography is a modification of conventional MRI techniques dedicated to evaluation of peripheral nerves and is being increasingly used for imaging of peripheral neuropathies at various sites in the body. Read More

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http://dx.doi.org/10.1148/rg.2018170194DOI Listing
December 2018
10 Reads

Vibrant Soundbridge implantation via a retrofacial approach in a patient with congenital aural atresia.

Auris Nasus Larynx 2019 Apr 7;46(2):204-209. Epub 2018 Sep 7.

Sen-En Rifu Otologic Surgery Center, Miyagi-gun, Miyagi, Japan.

Objective: A method of Vibrant Soundbridge (VSB) placement to the round window (RW) via the retrofacial approach with preoperative evaluation of the relationship between the facial nerve (FN) and RW by 3D-CT reconstruction was proposed for the treatment of congenital aural atresia (CAA) patient.

Methods: A fenestration to the mesotympanum was made mastoid portion of the FN. During the approach, part of the stapedial muscle was encountered and removed. Read More

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http://dx.doi.org/10.1016/j.anl.2018.08.012DOI Listing
April 2019
4 Reads

Isolated Congenital Absence of Cranial Nerves: Report of Two Cases.

Neuropediatrics 2018 12 10;49(6):405-407. Epub 2018 Sep 10.

Department of Radiodiagnosis and Pediatric Neurology, PGIMER, Chandigarh, Punjab, India.

Isolated cranial nerve absence is a rare condition that can be diagnosed using high-resolution cranial nerve magnetic resonance (MR) imaging. Thorough clinical examination with proper knowledge of the course of cranial nerves may help diagnose this rare condition. We describe two cases, one each of, isolated congenital absence of the third and seventh cranial nerve with their clinical presentation. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669923
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http://dx.doi.org/10.1055/s-0038-1669923DOI Listing
December 2018
1 Read
1.104 Impact Factor

Further evidence for complex inheritance of holoprosencephaly: Lessons learned from pre- and postnatal diagnostic testing in Germany.

Am J Med Genet C Semin Med Genet 2018 06;178(2):198-205

Center for Human Genetics Regensburg, Regensburg, Germany.

Holoprosencephaly (HPE) has been defined as a distinct clinical entity with characteristic facial gestalt, which may-or may not-be associated with the true brain malformation observed postmortem in autopsy or in pre- or postnatal imaging. Affected families mainly show autosomal dominant inheritance with markedly reduced penetrance and extremely broad clinical variability even between mutation carriers within the same families. We here present advances in prenatal imaging over the last years, increasing the proportion of individuals with HPE identified prenatally including milder HPE forms and more frequently allowing to detect more severe forms already in early gestation. Read More

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http://dx.doi.org/10.1002/ajmg.c.31625DOI Listing
June 2018
15 Reads

Quantitative and Neurovascular Anatomy of the Growing Gracilis Muscle in the Human Fetuses.

J Craniofac Surg 2018 Oct;29(7):e686-e690

Department of Anatomy.

This study is intended to obtain the algebraic growth dynamics of the gracilis in fetuses and determine the variations of neurovascular pedicle(s) of the gracilis, to aid infant surgeries. Forty fetuses (19 males and 21 females) were included in the study. Gestational mean age of the fetuses was 22. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004921DOI Listing
October 2018
47 Reads

Visualization of the Membranous Labyrinth and Nerve Fiber Pathways in Human and Animal Inner Ears Using MicroCT Imaging.

Front Neurosci 2018 31;12:501. Epub 2018 Jul 31.

VetImaging, VetCore Facility for Research, University of Veterinary Medicine, Vienna, Austria.

Design and implantation of bionic implants for restoring impaired hair cell function relies on accurate knowledge about the microanatomy and nerve fiber pathways of the human inner ear and its variation. Non-destructive isotropic imaging of soft tissues of the inner ear with lab-based microscopic X-ray computed tomography (microCT) offers high resolution but requires contrast enhancement using compounds with high X-ray attenuation. We evaluated different contrast enhancement techniques in mice, cat, and human temporal bones to differentially visualize the membranous labyrinth, sensory epithelia, and their innervating nerves together with the facial nerve and middle ear. Read More

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http://dx.doi.org/10.3389/fnins.2018.00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079228PMC
July 2018
23 Reads

Reporting and Description for Congenital Middle Ear Malformations to Facilitate Surgical Management.

Authors:
Feng Yang Yang Liu

Ann Otol Rhinol Laryngol 2018 Oct 9;127(10):717-725. Epub 2018 Aug 9.

2 Department of Otolaryngology, Navy General Hospitasl, PLA, Beijing, China.

Introduction: The aim of this work was to report and describe the different types of congenital middle ear malformations in order to guide surgical treatment approaches and improve outcomes for affected patients.

Methods: The authors reviewed patients with congenital middle ear malformations who received surgical treatment between September 2010 and March 2017. Patient characteristics, middle ear deformities, and surgical procedures were documented. Read More

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http://dx.doi.org/10.1177/0003489418792939DOI Listing
October 2018
6 Reads

Magnetic resonance imaging of developmental facial paresis: a spectrum of complex anomalies.

Neuroradiology 2018 Oct 3;60(10):1053-1061. Epub 2018 Aug 3.

Clinical Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Cairo, Egypt.

Purpose: Despite its clinical implications, the MRI features of developmental facial paresis (DFP) were described in a few case reports. This study aims to describe MRI features of DFP in relation to the embryological development with a proposed radiological new grading system.

Methods: The clinical records and MRI of the brain and internal auditory canal of 11 children with DFP were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00234-018-2063-8DOI Listing
October 2018
38 Reads

A re-evaluation of the basicranial soft tissues and pneumaticity of the therizinosaurian Nothronychus mckinleyi (Theropoda; Maniraptora).

PLoS One 2018 31;13(7):e0198155. Epub 2018 Jul 31.

White Mountain Dinosaur Exploration Center, Springerville, Arizona, United States of America.

The soft-tissue reconstruction and associated osteology of the North American therizinosaurian Nothronychus mckinleyi is updated. The cranial nerve topology is revised, bringing it more in line with coelurosaurs. The trunk of the trigeminal nerve is very short, with an incompletely intracranial trigeminal ganglion, an ophthalmic branch diverging anteriorly first, with later divergences of the maxillomandibular branches, following typical pathways. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198155PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067709PMC
December 2018
43 Reads

Cochlear implantation in children with CHARGE syndrome: a report of eight cases.

Eur Arch Otorhinolaryngol 2018 Aug 3;275(8):1987-1993. Epub 2018 Jul 3.

Department of Audiology, University of Milano, IRCSS Policlinico "Ca' Granda", Milan, Italy.

Objective: To report neuroradiologic findings, surgical strategies and clinical and audiological results in a series of children with CHARGE syndrome (CS) who had been evaluated for cochlear implantation (CI).

Study Design: Retrospective case series.

Setting: Tertiary referral university hospital. Read More

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http://dx.doi.org/10.1007/s00405-018-5053-xDOI Listing
August 2018
5 Reads

Middle Cranial Fossa Approach to Repair Tegmen Defects with Autologous or Alloplastic Graft.

World Neurosurg 2018 Oct 2;118:e10-e17. Epub 2018 Jun 2.

Division of Neurological Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA. Electronic address:

Background: Temporal bone tegmen defects may be associated with cerebrospinal fluid (CSF) otorrhea. A variety of techniques have been used for repair. We report our experience with skull base reconstruction for tegmen defects using either autologous or alloplastic grafts. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.196DOI Listing
October 2018
34 Reads