2,606 results match your criteria FEMS immunology and medical microbiology[Journal]


Retraction. The role of nitric oxide in inflammatory reactions.

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FEMS Immunol Med Microbiol 2012 Dec;66(3):449

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http://dx.doi.org/10.1111/1574-695X.12012DOI Listing
December 2012
5 Reads

Pluronic P85 enhances the efficacy of outer membrane vesicles as a subunit vaccine against Brucella melitensis challenge in mice.

FEMS Immunol Med Microbiol 2012 Dec;66(3):436-44

Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Disease, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.

Brucellosis is the most common zoonotic disease worldwide, and there is no vaccine for human use. Brucella melitensis Rev1, a live attenuated strain, is the commercial vaccine for small ruminants to prevent B. melitensis infections but has been associated with abortions in animals. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/1
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http://dx.doi.org/10.1111/1574-695X.12010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426994PMC
December 2012
9 Reads

Mannose receptor, C type 1 contributes to bacterial uptake by placental trophoblast giant cells.

FEMS Immunol Med Microbiol 2012 Dec;66(3):427-35

The United Graduate School of Veterinary Science, and Laboratory of Veterinary Public Health, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

During pregnancy, maternal immune function is strictly controlled and immune tolerance is induced. Trophoblast giant (TG) cells exhibit phagocytic activity and show macrophage-like activity against microorganisms in the placenta. However, details of molecular receptors and mechanisms for uptake by TG cells have not been clarified. Read More

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http://dx.doi.org/10.1111/1574-695X.12009DOI Listing
December 2012
8 Reads

Immunogenicity and therapeutic effects of Ag85A/B chimeric DNA vaccine in mice infected with Mycobacterium tuberculosis.

FEMS Immunol Med Microbiol 2012 Dec;66(3):419-26

Army Tuberculosis Prevention and Control Key Laboratory, Institute of Tuberculosis Research, the 309th Hospital of Chinese PLA, Beijing, China.

The situation of tuberculosis (TB) is very severe in China. New therapeutic agents or regimens to treat TB are urgently needed. In this study, Mycobacterium tuberculosis-infected mice were given immunotherapy intramuscularly with Ag85A/B chimeric DNA or saline, plasmid vector pVAX1, or Mycobacterium vaccae vaccine. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/1
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http://dx.doi.org/10.1111/1574-695X.12008DOI Listing
December 2012
15 Reads

Alcohol treatment enhances Staphylococcus aureus biofilm development.

FEMS Immunol Med Microbiol 2012 Dec;66(3):411-8

Department of Biology, IUPUI, Indianapolis, IN 46202, USA.

Staphylococcus aureus forms pathogenic biofilms. Previous studies have indicated that ethanol supplementation during S. aureus biofilm formation results in increased biofilm formation and changes in gene expression. Read More

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http://dx.doi.org/10.1111/1574-695X.12005DOI Listing
December 2012
8 Reads

Human intestinal epithelial cell-derived molecule(s) increase enterohemorrhagic Escherichia coli virulence.

FEMS Immunol Med Microbiol 2012 Dec;66(3):399-410

Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.

To better understand the role of host cell-derived molecules on enterohemorrhagic Escherichia coli (EHEC) infection, we studied EHEC virulence gene expression when exposed to cell-free spent (conditioned) medium (CM) from HCT-8 intestinal epithelial cells. Exposure to HCT-8 CM for 1 h and 3 h increased the expression of 32 of 41 EHEC locus of enterocyte effacement (LEE) virulence genes compared with fresh medium (FM). Expression of the Shiga toxin 1 (stx1B) gene was up-regulated at 1 h of exposure. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/1
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http://dx.doi.org/10.1111/1574-695X.12004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561499PMC
December 2012
9 Reads

Improved diagnostic power by combined interferon-gamma release assay and nested-PCR in tuberculous pleurisy in high tuberculosis prevalence area.

FEMS Immunol Med Microbiol 2012 Dec;66(3):393-8

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

The conventional acid fast bacilli (AFB) smear and Mycobacterium tuberculosis (M.tb) culture of pleural effusion and tuberculin skin test (TST) in tuberculous pleurisy are unable to meet clinical needs because of their low sensitivities and specificities. To evaluate the diagnostic accuracies of QuantiFERON TB Gold In-Tube test (QFT-GIT) and nested-PCR in tuberculous pleurisy, we conducted a cross-sectional study in regions of China with a high tuberculosis (TB) epidemic. Read More

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http://dx.doi.org/10.1111/1574-695X.12006DOI Listing
December 2012
6 Reads

Structural, serological, and genetic characterization of the O-antigen of Providencia alcalifaciens O40.

FEMS Immunol Med Microbiol 2012 Dec;66(3):382-92

TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.

The O-polysaccharide chain of the lipopolysaccharide (O-antigen) on the bacterial cell surface is one of the most structurally variable cell components and serves as a basis for serotyping of Gram-negative bacteria, including human opportunistic pathogens of the genus Providencia. In this work, the O-antigen of Providencia alcalifaciens O40 was obtained by mild acid degradation of the isolated lipopolysaccharide and studied by chemical methods and high-resolution NMR spectroscopy. The following structure of the O-polysaccharide was established: →4)-β-D-Quip3NFo-(1→3)-α-D-Galp-(1→3)-β-D-GlcpA-(1→3)-β-D-GalpNAc-(1→, where GlcA stands for glucuronic acid and Qui3NFo for 3,6-dideoxy-3-formamidoglucose. Read More

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http://dx.doi.org/10.1111/1574-695X.12002DOI Listing
December 2012
11 Reads

Bill Costerton: leader as servant.

FEMS Immunol Med Microbiol 2012 Dec;66(3):269-72

Department of Microbial Pathogenesis, Dental School, University of Maryland-Baltimore, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/1574-695X.12011DOI Listing
December 2012
8 Reads
3.078 Impact Factor

Nonencapsulated Streptococcus pneumoniae resists extracellular human neutrophil elastase- and cathepsin G-mediated killing.

FEMS Immunol Med Microbiol 2012 Dec 24;66(3):445-8. Epub 2012 Sep 24.

Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.

Although the Streptococcus pneumoniae polysaccharide capsule is an important virulence factor, ~ 15% of carriage isolates are nonencapsulated. Nonencapsulated S. pneumoniae are a cause of mucosal infections. Read More

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http://femsim.oxfordjournals.org/content/femsim/66/3/445.ful
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http://femsim.oxfordjournals.org/lookup/doi/10.1111/j.1574-6
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http://dx.doi.org/10.1111/j.1574-695X.2012.01028.xDOI Listing
December 2012
8 Reads

Accumulation of staphylococcal Panton-Valentine leukocidin in the detergent-resistant membrane microdomains on the target cells is essential for its cytotoxicity.

FEMS Immunol Med Microbiol 2012 Dec 12;66(3):343-52. Epub 2012 Sep 12.

Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

The mechanisms for the cytotoxicity of staphylococcal Panton-Valentine leukocidin (PVL), a pore-forming toxin consisting of LukS-PV and LukF-PV, in human immune cells are still unclear. Because LukS-PV binds to ganglioside GM1, a constituent of detergent-resistant membrane microdomains (DRMs) of the plasma membrane, the role of DRMs in PVL cytotoxicity was examined in human polymorphonuclear neutrophils (PMNs), monocytes, HL-60 cells, and THP-1 cells. PVL binding capacities in HL-60 and THP-1 cells were higher than those in PMNs and monocytes; however, the PVL concentration to obtain more than 80% cell lysis in HL-60 cells was 10 times higher than that in PMNs and PVL even at such concentration induced < 10% cell lysis in THP-1 cells. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.01027.xDOI Listing
December 2012
11 Reads

Immune and acute phase response in pigs experimentally infected with H1N2 swine influenza virus.

FEMS Immunol Med Microbiol 2012 Dec 12;66(3):334-42. Epub 2012 Sep 12.

Department of Swine Diseases, National Veterinary Research Institute, Puławy, Poland.

Acute phase proteins (APPs) and immune responses in pigs after experimental infection with H1N2 swine influenza virus (SwH1N2) were studied. Eight piglets were infected intranasally with SwH1N2. Four served as controls. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01026.xDOI Listing
December 2012
9 Reads

Mycobacterium tuberculosis H37Rv is more effective compared to vaccine strains in modulating neutrophil functions: an in vitro study.

FEMS Immunol Med Microbiol 2012 Dec 12;66(3):372-81. Epub 2012 Sep 12.

Department of Immunology, National Institute for Research in Tuberculosis, Chetput, Chennai, India.

Neutrophils are the primary cells contributing to initial defense against mycobacteria. Yet, little is known about the potential of various mycobacterial strains to stimulate neutrophils. This study was focused to compare the differential capacity of vaccine strains, Mycobacterium bovis bacillus Calmette-Guerin (BCG) and Mycobacterium indicus pranii (Mw), and laboratory strain H37Rv to activate and enhance neutrophil functions. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01025.xDOI Listing
December 2012
14 Reads

Differential induction of macrophage cell death by antigens of a clustered and a non-clustered multidrug-resistant Mycobacterium tuberculosis strain from Haarlem family.

FEMS Immunol Med Microbiol 2012 Dec 10;66(3):363-71. Epub 2012 Sep 10.

Instituto de Medicina Experimental-CONICET, Buenos Aires, Argentina.

Some multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) genotypes are the cause of large outbreaks, including strain M identified in Argentina. In contrast, its kin strain 410 has only caused a single case to date. Cell wall antigens from Mtb were associated with the modulation of macrophage (MΦ) cell death, and the ability to inhibit of MΦ apoptosis is considered a virulence mechanism. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.01024.xDOI Listing
December 2012
19 Reads

Evidence of immunomodulatory effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486.

FEMS Immunol Med Microbiol 2012 Dec 31;66(3):353-62. Epub 2012 Aug 31.

Department of Food and Nutritional Sciences, The University of Reading, Reading, UK.

Bifidobacterium longum bv. infantis CCUG 52486 was originally isolated from healthy elderly subjects and demonstrated to have particular ecological fitness and anti-pathogenic effects. Bifidobacteria are commonly associated with immuno-modulatory properties, especially in older people, but this strain has not been investigated for effects on immune function. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.01014.xDOI Listing
December 2012
9 Reads

Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.

FEMS Immunol Med Microbiol 2012 Dec 21;66(3):323-33. Epub 2012 Aug 21.

The Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Nankai University, Tianjin, China.

Lipopolysaccharides on the cell surface of Gram-negative bacteria are an important factor in pathogenicity, and the O-specific polysaccharide chain (O-polysaccharide, O-antigen) defines the immunospecificity of different bacterial strains. Cronobacter turicensis is an emerging foodborne pathogen which causes severe invasive infections in neonates. In this study, a new O serotype, C. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01013.xDOI Listing
December 2012
10 Reads

Arginase-1 expression in granulomas of tuberculosis patients.

FEMS Immunol Med Microbiol 2012 Nov 21;66(2):265-8. Epub 2012 Aug 21.

Departamento de Patologia e Laboratórios, Disciplina de Anatomia Patológica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen able to survive and multiply within macrophages. Several mechanisms allow this bacterium to escape macrophage microbicidal activity. Mtb may interfere with the ability of mouse macrophages to produce antibactericidal nitric oxide, by inducing the expression of arginase 1 (Arg1). Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01012.xDOI Listing
November 2012
8 Reads
21 Citations
3.080 Impact Factor

Role of Vpma phase variation in Mycoplasma agalactiae pathogenesis.

FEMS Immunol Med Microbiol 2012 Dec 21;66(3):307-22. Epub 2012 Aug 21.

Institute of Bacteriology, Mycology and Hygiene, Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria.

Compared with other bacterial pathogens, the molecular mechanisms of mycoplasma pathogenicity are largely unknown. Several studies in the past have shown that pathogenic mycoplasmas are equipped with sophisticated genetic systems that allow them to undergo high-frequency surface antigenic variations. Although never clearly proven, these variable mycoplasma surface components are often implicated in host immune evasion and adaptation. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01010.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510919PMC
December 2012
13 Reads
3.078 Impact Factor

Enteroaggregative Escherichia coli pathotype: a genetically heterogeneous emerging foodborne enteropathogen.

FEMS Immunol Med Microbiol 2012 Dec 31;66(3):281-98. Epub 2012 Jul 31.

Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del IPN, México DF, Mexico.

Until now, a common feature that defines the enteroaggregative Escherichia coli (EAEC) strains is the ability to produce a 'stacked-brick' appearance on epithelial cells, but it does not distinguish between pathogenic and nonpathogenic strains. Numerous adhesins, toxins, and proteins associated with virulence have been described, as well as multiple factors contributing to EAEC-induced inflammation. None of these factors are found in all EAEC isolates, and no single factor has ever been implicated in EAEC virulence. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01008.xDOI Listing
December 2012
13 Reads

Increased frequencies of Th17 and Th22 cells in the peripheral blood of patients with secondary syphilis.

FEMS Immunol Med Microbiol 2012 Dec 31;66(3):299-306. Epub 2012 Jul 31.

Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Anhui, China.

T-helper (Th) 17 and the more recently identified Th22 cells are of great importance in host defense against pathogens, but can also be responsible for chronic inflammatory disorders. However, the roles of the two cell subsets in syphilis remain elusive. In this study, we show that the frequencies of Th17 and Th22 cells are significantly increased in the peripheral blood of patients with secondary syphilis (SS). Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01007.xDOI Listing
December 2012
13 Reads

Immunomodulating and anti-infective effects of a novel strain of Lactobacillus paracasei that strongly induces interleukin-12.

FEMS Immunol Med Microbiol 2012 Nov 23;66(2):230-9. Epub 2012 Jul 23.

Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan.

Several studies have demonstrated that some strains of lactic acid bacteria (LAB) can elicit natural killer (NK) cell activities via interleukin-12 (IL-12) induction and protect against influenza virus (IFV) infection. LAB strains that strongly induce IL-12 are expected to be effective in protecting against IFV infection. In this study, we screened 85 strains for their ability to induce the in vitro production of IL-12, and Lactobacillus paracasei MoLac-1 most strongly induced IL-12. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.01003.xDOI Listing
November 2012
18 Reads

Biofilm dispersal cells of a cystic fibrosis Pseudomonas aeruginosa isolate exhibit variability in functional traits likely to contribute to persistent infection.

FEMS Immunol Med Microbiol 2012 Nov 31;66(2):251-64. Epub 2012 Jul 31.

School of Biotechnology and Biomolecular Sciences, Centre for Marine Bio-Innovation, University of New South Wales, Sydney, NSW, Australia.

Persistent lung infection by Pseudomonas aeruginosa is typically associated with the development of biofilms, the appearance of morphotypic variants and reduction in the expression of acute virulence factors. We have characterised and compared functional traits [carbon substrate utilisation, attachment and biofilm formation, protease and elastase activity, quorum-sensing (QS)] of the biofilm dispersal populations of a representative P. aeruginosa isolate from a chronically infected cystic fibrosis individual and P. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01006.xDOI Listing
November 2012
11 Reads

Prevalence of genes encoding extracellular proteases in Staphylococcus aureus - important targets triggering immune response in vivo.

FEMS Immunol Med Microbiol 2012 Nov 31;66(2):220-9. Epub 2012 Jul 31.

Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Proteases of Staphylococcus aureus have long been considered to function as important virulence factors, although direct evidence of the role of particular enzymes remains incomplete and elusive. Here, we sought to provide a collective view of the prevalence of extracellular protease genes in genomes of commensal and pathogenic strains of S. aureus and their expression in the course of human and mouse infection. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01005.xDOI Listing
November 2012
26 Reads

Outer membrane vesicles of Shigella boydii type 4 induce passive immunity in neonatal mice.

FEMS Immunol Med Microbiol 2012 Nov 1;66(2):240-50. Epub 2012 Aug 1.

Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata, India.

Like most other Gram-negative bacteria, Shigella releases outer membrane vesicles (OMVs) into the surrounding environment during growth. In this study, we have exploited OMVs of Shigella as a protective immunogen in a mice model against Shigellosis. Distinctive vesicle secretion was noticed from different Shigella strains. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01004.xDOI Listing
November 2012
17 Reads

Purified protein derivatives of tuberculin--past, present, and future.

FEMS Immunol Med Microbiol 2012 Dec 1;66(3):273-80. Epub 2012 Aug 1.

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523-1682, USA.

The tuberculin skin test, which involves monitoring the immune reaction to an injection of purified protein derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01002.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491170PMC
December 2012
12 Reads

Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection.

FEMS Immunol Med Microbiol 2012 Nov 23;66(2):211-9. Epub 2012 Jul 23.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

The Gram-negative obligate intracellular bacterium Anaplasma phagocytophilum is the causative agent of human granulocytic anaplasmosis (HGA), an emerging tick-borne infectious disease occurring worldwide. HGA is generally self-limiting; however, the underlying mechanisms, particularly the innate immune pathways that mediate the immune clearance of A. phagocytophilum, are less understood. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.01001.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530031PMC
November 2012
12 Reads

Shigella flexneri O-antigens revisited: final elucidation of the O-acetylation profiles and a survey of the O-antigen structure diversity.

FEMS Immunol Med Microbiol 2012 Nov 17;66(2):201-10. Epub 2012 Jul 17.

N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Shigella flexneri is an important human pathogen causing shigellosis. Strains of S. flexneri are serologically heterogeneous and, based on O-antigens, are currently classified into 14 types. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.01000.xDOI Listing
November 2012
13 Reads

Stenotrophomonas maltophilia flagellin restricts bacterial colonization in BALB/c mouse lung in vivo.

FEMS Immunol Med Microbiol 2012 Nov 16;66(2):191-200. Epub 2012 Jul 16.

Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.

Stenotrophomonas maltophilia is an emerging drug-resistant pathogen. Here, we demonstrated that S. maltophilia flagellin could locally activate innate immunity thereby increase the resistance to respiratory tract infection (RTI) and improved bacterial clearance in the lungs of BALB/c mice. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00999.xDOI Listing
November 2012
7 Reads

Identification of key proteins of cultured human intestinal cells involved in interaction with enteroaggregative Escherichia coli.

FEMS Immunol Med Microbiol 2012 Nov 4;66(2):177-90. Epub 2012 Jul 4.

Department of Experimental Medicine & Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Enteroaggregative Escherichia coli (EAEC) adherence to human intestinal tissue is known to be mediated by aggregative adherence fimbriae (AAF). However, the host cell molecules involved in EAEC adherence remain uncharacterized. In the present study, four key membrane glycoproteins of cultured human intestinal epithelial cells (INT-407) were found to be involved in the interaction with the T8 strain of EAEC. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.00998.xDOI Listing
November 2012
9 Reads

Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages.

FEMS Immunol Med Microbiol 2012 Nov 27;66(2):166-76. Epub 2012 Jun 27.

Research Group for Host-Microbe Interactions, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

Gentamicin is important in synergistic bactericidal therapy with cell wall agents for severe enterococcal infections. During 2003-2008, a 10-fold increase in the prevalence of high-level gentamicin resistance (HLGR), to above 50%, in blood culture isolates of Enterococcus faecium, was reported by the Norwegian Surveillance System for Antimicrobial Resistance. A representative national collection of invasive E. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00997.xDOI Listing
November 2012
24 Reads

Borrelia burgdorferi malQ mutants utilize disaccharides and traverse the enzootic cycle.

FEMS Immunol Med Microbiol 2012 Nov 21;66(2):157-65. Epub 2012 Jun 21.

Division of Biological Sciences, The University of Montana, Missoula, MT 59812-4824, USA.

Borrelia burgdorferi, the causative agent of Lyme disease, cycles in nature between a vertebrate host and a tick vector. We demonstrate that B. burgdorferi can utilize several sugars that may be available during persistence in the tick, including trehalose, N-acetylglucosamine (GlcNAc), and chitobiose. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00996.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465622PMC
November 2012
7 Reads

Genetic polymorphisms of molecules involved in host immune response to dengue virus infection.

FEMS Immunol Med Microbiol 2012 Nov 21;66(2):134-46. Epub 2012 Jun 21.

Department of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Key Laboratory of Microbial Engineering under Educational Committee in Chongqing, Chongqing, China.

The dengue virus (DENV) belongs to the flavivirus family. Each of the four distinct serotypes of this virus is capable of causing human disease, especially in tropical and subtropical areas. The majority of people infected with DENV manifest asymptomatic or dengue fever with flu-like self-limited symptoms. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00995.xDOI Listing
November 2012
6 Reads

Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells.

FEMS Immunol Med Microbiol 2012 Nov 21;66(2):147-56. Epub 2012 Jun 21.

School of Science and Technology, Örebro Life Science Center, Örebro University, Örebro, Sweden.

Lactobacillus rhamnosus GR-1 is a probiotic bacterium used to maintain urogenital health. The putative mechanism for its probiotic effect is by modulating the host immunity. Urinary tract infections (UTI) are often caused by uropathogenic Escherichia coli that frequently evade or suppress immune responses in the bladder and can target pathways, including nuclear factor-kappaB (NF-κB). Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00994.xDOI Listing
November 2012
16 Reads

Immune stimulating and therapeutic potential of tuftsin-incorporated nystatin liposomes against Cryptococcus neoformans in leukopenic BALB/C mice.

FEMS Immunol Med Microbiol 2012 Oct 11;66(1):88-97. Epub 2012 Jul 11.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, India.

Cryptococcus neoformans infection is a common fungal infection in persons infected with human immune deficiency virus (HIV) or those with defective cell-mediated immunity. Since treatment of cryptococcal meningitis poses a big challenge, the present study aimed to develop a novel liposomal therapeutic formulation against cryptococcosis. Treatment with tuftsin-incorporated liposomes increased the anti-cryptococcal activity of murine peritoneal macrophages. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00992.xDOI Listing
October 2012
11 Reads

Effects of probiotics, probiotic DNA and the CpG oligodeoxynucleotides on ovalbumin-sensitized Brown-Norway rats via TLR9/NF-κB pathway.

FEMS Immunol Med Microbiol 2012 Oct 18;66(1):71-82. Epub 2012 Jun 18.

Clinical Nutrition Center, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, China.

The aim of the study was to investigate the effect of living probiotics, probiotic DNA and the synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODN) on both immune response and intestinal barrier function in ovalbumin-sensitized rat and the underlying mechanisms. Brown-Norway rats were orally sensitized with ovalbumin, and living probiotics, probiotic DNA extraction, synthetic CpG-ODN or non-CpG ODN control was administered. In the living probiotics, probiotic DNA and CpG-ODN groups, the allergic response was significantly inhibited, the Th1/Th2 cytokine balance was shifted away from Th2 side, the percentage of CD4(+) CD25(+high) Treg cells was increased, and the intestinal barrier function was improved. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.00991.xDOI Listing
October 2012
8 Reads

A one dose experimental cholera vaccine.

FEMS Immunol Med Microbiol 2012 Oct 21;66(1):98-115. Epub 2012 Jun 21.

Dartmouth College, Lebanon, NH, USA.

The number of cholera vaccine doses required for immunity is a constraint during epidemic cholera. Protective immunity following one dose of multiple Vibrio cholerae (Vc) colonization factors (Inaba LPS El Tor, TcpA, TcpF, and CBP-A) has not been directly tested even though individual Vc colonization factors are the protective antigens. Inaba LPS consistently induced vibriocidal and protective antibodies at low doses. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00993.xDOI Listing
October 2012
6 Reads

Assessment of cellular immune parameters in paediatric toxic shock syndrome: a report of five cases.

FEMS Immunol Med Microbiol 2012 Oct 18;66(1):116-9. Epub 2012 Jun 18.

Centre National de Références des Staphylocoques, Faculté de Médecine Lyon Est, Université de Lyon, France.

Toxic shock syndrome (TSS) and septic shock (SS) share many clinical signs of an exacerbated inflammatory response. In this report, we investigated whether TSS presents similar features of delayed immunosuppression as described in SS. Five children with TSS from paediatric intensive care units in a university hospital were monitored. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00990.xDOI Listing
October 2012
15 Reads

Porphyromonas gingivalis fimbriae carbohydrate specificity assessment by glycomics.

FEMS Immunol Med Microbiol 2012 Oct 13;66(1):83-7. Epub 2012 Jun 13.

Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, USA.

Porphyromonas gingivalis is a major pathogen in adult periodontitis. Fimbriae play an important role in the initial interaction between the bacteria and the host. Our earlier studies suggested that the oligosaccharide moiety of lactoferrin is involved in the interaction with fimbriae. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00989.xDOI Listing
October 2012
7 Reads

New pertussis vaccination approaches: en route to protect newborns?

FEMS Immunol Med Microbiol 2012 Nov 13;66(2):121-33. Epub 2012 Jun 13.

Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, France.

Pertussis or whooping cough is a life-threatening childhood disease, particularly severe during the first months of life, although adolescent and adult pertussis is increasingly more noted. General vaccination has tremendously reduced its incidence but has failed to bring it completely under control. In fact, it remains one of the most poorly controlled vaccine-preventable diseases in the world. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00988.xDOI Listing
November 2012
7 Reads

Diagnosis of extrapulmonary tuberculosis by PCR.

FEMS Immunol Med Microbiol 2012 Oct 29;66(1):20-36. Epub 2012 Jun 29.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, India.

During the last two decades, the resurgence of tuberculosis (TB) has been documented in both developed and developing nations, and much of this increase in TB burden coincided with human immunodeficiency virus (HIV) epidemics. Since then, the disease pattern has changed with a higher incidence of extrapulmonary tuberculosis (EPTB) as well as disseminated TB. EPTB cases include TB lymphadenitis, pleural TB, TB meningitis, osteoarticular TB, genitourinary TB, abdominal TB, cutaneous TB, ocular TB, TB pericarditis and breast TB, although any organ can be involved. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00987.xDOI Listing
October 2012
11 Reads
21 Citations
3.080 Impact Factor

Paracoccidioides brasiliensis lipids modulate macrophage activity via Toll-dependent or independent mechanisms.

FEMS Immunol Med Microbiol 2012 Oct 30;66(1):58-70. Epub 2012 May 30.

Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.

The macrophages are the first host cells that interact with the fungus Paracoccidioides brasiliensis, but the main mechanisms that regulate this interaction are not well understood. Because the role played by P. brasiliensis lipids in macrophage activation was not previously investigated, we aimed to assess the influence of diverse lipid fractions from P. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00986.xDOI Listing
October 2012
8 Reads

Brucella invasion of human intestinal epithelial cells elicits a weak proinflammatory response but a significant CCL20 secretion.

FEMS Immunol Med Microbiol 2012 Oct 28;66(1):45-57. Epub 2012 May 28.

Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.

In spite of the frequent acquisition of Brucella infection by the oral route in humans, the interaction of the bacterium with cells of the intestinal mucosa has been poorly studied. Here, we show that different Brucella species can invade human colonic epithelial cell lines (Caco-2 and HT-29), in which only smooth species can replicate efficiently. Infection with smooth strains did not produce a significant cytotoxicity, while the rough strain RB51 was more cytotoxic. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.00985.xDOI Listing
October 2012
9 Reads

Understanding biofilms--are we there yet?

FEMS Immunol Med Microbiol 2012 Jul 21;65(2):125-6. Epub 2012 May 21.

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http://dx.doi.org/10.1111/j.1574-695X.2012.00984.xDOI Listing
July 2012
8 Reads

Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections.

FEMS Immunol Med Microbiol 2012 Jul 1;65(2):215-25. Epub 2012 Jun 1.

Department of International Health, Immunology and Microbiology, Unit of Bacteriology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

During chronic lung infection of patients with cystic fibrosis, Pseudomonas aeruginosa can survive for long periods of time under the challenging selective pressure imposed by the immune system and antibiotic treatment as a result of its biofilm mode of growth and adaptive evolution mediated by genetic variation. Mucoidy, hypermutability and acquirement of mutational antibiotic resistance are important adaptive phenotypes that are selected during chronic P. aeruginosa infection. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.00983.xDOI Listing
July 2012
9 Reads

Doxycycline inhibits TREM-1 induction by Porphyromonas gingivalis.

FEMS Immunol Med Microbiol 2012 Oct 21;66(1):37-44. Epub 2012 May 21.

Oral Translational Research, Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Switzerland.

The triggering receptor expressed on myeloid cells 1 (TREM-1) is a cell surface receptor of the immunoglobulin superfamily, with the capacity to amplify pro-inflammatory cytokine production. Porphyromonas gingivalis is a Gram-negative anaerobic species highly implicated in inflammatory periodontal disease, with potential involvement in systemic inflammation. Porphyromonas gingivalis positively regulates TREM-1 expression and production in monocytic cells. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00982.xDOI Listing
October 2012
13 Reads

Immunomodulatory effects of potential probiotics in a mouse peanut sensitization model.

FEMS Immunol Med Microbiol 2012 Aug 24;65(3):488-96. Epub 2012 May 24.

Top Institute Food and Nutrition, Wageningen, The Netherlands.

Peanut allergy accounts for the majority of severe food-related allergic reactions and there is a need for new prevention and treatment strategies. Probiotics may be considered for treatment on the basis of their immunomodulating properties. Cytokine profiles of probiotic strains were determined by in vitro co-culture with human PBMCs. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00981.xDOI Listing
August 2012
10 Reads

The role of Borrelia burgdorferi outer surface proteins.

FEMS Immunol Med Microbiol 2012 Oct 21;66(1):1-19. Epub 2012 May 21.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Human pathogenic spirochetes causing Lyme disease belong to the Borrelia burgdorferi sensu lato complex. Borrelia burgdorferi organisms are extracellular pathogens transmitted to humans through the bite of Ixodes spp. ticks. Read More

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http://femsim.oxfordjournals.org/content/femsim/66/1/1.full.
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http://femsim.oxfordjournals.org/cgi/doi/10.1111/j.1574-695X
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http://dx.doi.org/10.1111/j.1574-695X.2012.00980.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424381PMC
October 2012
8 Reads

Activation of COL1A2 promoter in human fibroblasts by Escherichia coli.

FEMS Immunol Med Microbiol 2012 Aug 18;65(3):481-7. Epub 2012 May 18.

Department of Microbiology, Tokyo Medical University, Tokyo, Japan.

The relationship between bacterial infection and collagen production was investigated using human fibroblasts transfected with the promoter of COL1A2 , which encodes the α1 chain of human type I collagen, linked to a luciferase reporter. The cells were used to assess the gene promoter activity of COL1A2 following bacterial stimulation. The COL1A2 promoter was activated by stimulation with fixed Escherichia coli in a dose-dependent manner, but not by fixed Staphylococcus aureus. Read More

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https://academic.oup.com/femspd/article-lookup/doi/10.1111/j
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http://dx.doi.org/10.1111/j.1574-695X.2012.00979.xDOI Listing
August 2012
8 Reads

Virulence factors in Proteus bacteria from biofilm communities of catheter-associated urinary tract infections.

FEMS Immunol Med Microbiol 2012 Jul 21;65(2):343-9. Epub 2012 May 21.

Faculty of Medicine, Institute for Microbiology, Masaryk University and St. Anna Teaching Hospital, Brno, Czech Republic.

More than 40% of nosocomial infections are those of the urinary tract, most of these occurring in catheterized patients. Bacterial colonization of the urinary tract and catheters results not only in infection, but also various complications, such as blockage of catheters with crystalline deposits of bacterial origin, generation of gravels and pyelonephritis. The diversity of the biofilm microbial community increases with duration of catheter emplacement. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00976.xDOI Listing
July 2012
31 Reads

Exploring the applications of invertebrate host-pathogen models for in vivo biofilm infections.

FEMS Immunol Med Microbiol 2012 Jul 21;65(2):205-14. Epub 2012 May 21.

Department of Biological Sciences, Goucher College, Baltimore, MD 21204, USA.

In the natural environment, microorganisms exist together in self-produced polymeric matrix biofilms. Often, several species, which can belong to both bacterial and fungal kingdoms, coexist and interact in ways which are not completely understood. Biofilm infections have become prevalent largely in medical settings because of the increasing use of indwelling medical devices such as catheters or prosthetics. Read More

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http://dx.doi.org/10.1111/j.1574-695X.2012.00975.xDOI Listing
July 2012
9 Reads