Search Our Scientific Publications & Authors

Dev Dyn 2019 Jan 4. Epub 2019 Jan 4.

Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: The timing, location, and level of gene expression are crucial for normal organ development, since morphogenesis requires strict genetic control. MicroRNAs (miRNAs) are noncoding small single-stranded RNAs that play a critical role in regulating gene expression level. Although miRNAs are known to be involved in many biological events, the role of miRNAs in organogenesis is not fully understood. Read More

Ocul Oncol Pathol 2018 Jun 12;4(4):230-235. Epub 2018 Jan 12.

Department of Ophthalmic Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

Primary cutaneous angiosarcoma is a rare vasoformative malignant neoplasm that can present a diagnostic and therapeutic challenge. We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Read More

Arch Craniofac Surg 2018 Dec 27;19(4):254-259. Epub 2018 Dec 27.

Department of Dermatology, Pusan National University Hospital, Busan, Korea.

Background: The esthetic and functional outcomes of periorbital defect reconstruction are very important because of the complex anatomy and specialized functions of this region. The orbicularis oculi myocutaneous (OOMC) flap is useful for the reconstruction of periorbital defects. But, according to the location and depth of the defects, the reconstruction using OMC flaps with various techniques is rare. Read More

Pan Afr Med J 2018 26;30:226. Epub 2018 Jul 26.

Department of Dermatology and Venereology, Ibn Rochd University Hospital, Casablanca, Morocco.

Morbihan disease (MD) is a rare entity. Its nosography is unclear and its therapeutic management is difficult. We report a new case of MD. Read More

J Craniofac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Korea.

Background: The management of lower eyelid ectropion is considered a challenge. Lower eyelid ectropion is conventionally reconstructed with a full-thickness skin graft or a local flap. However, complications as scar contracture and the recurrence of ectropion frequently occur. Read More

Korean J Ophthalmol 2018 12;32(6):517-518

Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

Acta Vet Scand 2018 Dec 6;60(1):79. Epub 2018 Dec 6.

Eye Pathology Section, Department of Pathology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Frederik V's Vej, 11, 1st Floor, 2100, Copenhagen Ø, Denmark.

Background: Eyelid tumours are frequently found in dogs, most of these being benign. In case of an ulcerating eyelid tumour, malignancy must be considered. We report a unique case of a low-grade peripheral T-cell lymphoma in the eyelid of a 9-year-old English Setter. Read More

Rom J Morphol Embryol 2018 ;59(3):989-996

Department of Microscopic Morphology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania; Department of Otorhinolaryngology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Basal cell carcinoma (BCC) is the most common locally invasive malignant epidermal neoplasm. It is generally a tumor that runs a slow progressive course and can usually be cured by surgery. Basosquamous carcinoma is considered by some authors a rare subtype of BCC, while others describe it as independent tumor with different evolution from BCC. Read More

Rom J Morphol Embryol 2018 ;59(3):977-983

Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Beijing Lomeye Cosmetic Surgery Clinic, Beijing, China.

Background: Anti-aging in lower eyelid-cheek junction area has always been the upmost widely sought of cosmetic surgery. Removal of orbital fat from inside or outside, removal of part of the skin or even the orbicularis muscle, superficial pull and deep fill and a series of surgical procedures like these have been or are becoming the mainstream of clinical practice. However, aging involves a variety of tissues and causes, which is a dynamic and continuous process. Read More

Vet Anaesth Analg 2019 Jan 7;46(1):14-27. Epub 2018 Nov 7.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel. Electronic address:

Objective: Orbital and globe surgeries are commonly performed in companion animals and are considered to cause moderate to severe pain. Regional anesthesia techniques can provide complete sensory blockade, analgesia for painful procedures and improve surgical conditions. The purpose of this review is to summarize local and regional anesthesia techniques for ophthalmic surgery in dogs and cats with emphasis on veterinary publications in the past 12 years. Read More

Orbit 2018 Nov 27:1-4. Epub 2018 Nov 27.

a Oculoplastics Department , Instituto de Oftalmología Fundación Conde de Valenciana , Mexico City , Mexico.

Purpose: To describe and evaluate the eyelash transplantation with strip composite eyebrow graft to improve eyelid anatomy in tarsoconjunctival flap eyelid reconstruction procedure.

Methods: Twenty two patients with eyelid tumors managed by local excision and reconstruction using tarsoconjunctival flap reconstruction procedure were included. Eyelash graft was performed during flap division by harvesting a graft from the eyebrow and creating a recipient pocket in the receptor eyelid. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13186

Department of Plastic and Reconstructive Surgery.

Rationale: Ossifying fibroma (OF) is a benign fibro-osseous lesion that can develop in the oral and maxillofacial region. OF is more common in females and has a marked predilection for the mandible, occurring rarely in the maxilla. Lesions grow slowly and are usually asymptomatic until growth produces an obvious swelling, pain, paresthesia, and facial deformity. Read More

Aesthetic Plast Surg 2018 Nov 19. Epub 2018 Nov 19.

Department of Anatomy and Histo Embryology, School of Basic Medical Science, Peking University, Beijing, China.

Background: "European-style double eyelid" blepharoplasty often leads to a complex deformity, which includes one or more of the following features: a high fold, upper eyelid depression, multiple folds, an obvious scar, blepharoptosis, and lower flap tumidness. However, there is still a lack of comprehensive research on evaluation and treatment strategies for this complex deformity.

Methods: During a 6-year period, 65 patients (106 eyes) with a high fold and upper eyelid depression underwent corrective blepharoplasty. Read More

Sci Rep 2018 Nov 19;8(1):17042. Epub 2018 Nov 19.

Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea.

The orbicularis retaining ligament (ORL) is an important structure for maintaining the eyelid and cheek skin and contouring the characteristic facial appearance. However, the ORL is a delicate structure that is easily damaged in manual dissection. This study aimed to comprehensively investigate the ORL using a micro-computed tomography (mCT) with phosphotungstic acid (PTA) preparation for the acquisition of its three-dimensional information non-destructively. Read More

BMC Ophthalmol 2018 Nov 12;18(1):296. Epub 2018 Nov 12.

The School of Medicine, Nankai University, Tianjin, 300071, China.

Background: To evaluate the ophthalmic manifestations and radiographic features of ectopic orbital meningioma to improve diagnostic accuracy.

Methods: Patient data from patients admitted to our institution during a 217-month period from August 1999 to September 2017 were included. Patient ophthalmic manifestations, radiographic features (CT and MRI), diagnosis, pathology, therapeutic regimens, and prognosis were retrospectively reviewed. Read More

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e2-e3

Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, U.S.A.

Superficial subcutaneous lipomas are benign, slow-growing neoplasms comprised mature adipose cells that may be surrounded by a fibrous tissue capsule. While found commonly on the body, simple lipomas are rarely described in the eyelids. Reports of two eyelid lipomas in the literature describe the anatomy to be posterior to the orbital septum. Read More

BMC Ophthalmol 2018 Nov 7;18(1):291. Epub 2018 Nov 7.

Department of Oculoplastic and Reconstructive Surgery, Tianjin Aier Eye Hospital, No.102, Fukang Road, Nankai District, Tianjin, 300190, People's Republic of China.

Background: To report "Lamellar Rotation Surgery",a new technique for repairing large and moderate full-thickness upper eyelid defects.

Methods: A two-stage technique is described in which a vertical incision is made in the tarsus of the lower eyelid with elevation of the lateral posterior lamella while sparing the lower eyelid orbicularis and skin to be rotated superiorly to form the reconstructed posterior lamella of the upper eyelid. Additionally, a lateral periosteal flap is used to reconstruct the lateral canthal tendon, and a McGregor procedure is used to reconstruct the anterior lamella of the upper eyelid. Read More

Int J Dent 2018 9;2018:1601363. Epub 2018 Oct 9.

Division of Oral Anatomy, Department of Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

The tongue is a critical organ, involved in functions such as speaking, swallowing, mastication, and degustation. Although genes are known to play critical roles in many biological processes, including organogenesis, the expression of the family members during tongue development remains unclear. We therefore performed a comparative hybridization analysis of 17 genes ( and ) during murine tongue development. Read More

Eye (Lond) 2018 Nov 2. Epub 2018 Nov 2.

Department of Ophthalmology, Columbia University, New York, New York, USA.

Orbital decompression surgery and medical therapy for thyroid eye disease (TED) have evolved over the past 150 years and afforded the opportunity to restore pre-disease appearance and visual function. This manuscript explores the past 150 years of surgical innovation for the treatment of TED. The "Age of Surgical Heroism" spans the time from 1888 to 1979 during which the pioneers of orbital decompression developed lateral orbitotomy, transcranial decompression, paranasal sinus decompression, and transantral decompression despite an incomplete understanding of the pathophysiology of both TED and a limited ability to non-invasively assess their patients. Read More

PLoS One 2018 31;13(10):e0206642. Epub 2018 Oct 31.

Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

Purpose: Corneal anesthesia leads to chronic corneal injury. This anatomical study characterizes the donor nerve branches of the supratrochlear and supraorbital nerves used for corneal neurotization.

Methods: In 13 non-embalmed cadavers, the supratrochlear and supraorbital nerves were dissected and distances to anatomical landmarks measured. Read More

Pan Afr Med J 2018 19;30:139. Epub 2018 Jun 19.

Faculté de Médecine et de Pharmacie de Fès, CHU Hassan II, Fès, Maroc.

We here report the case of a 48-year old patient with a family history of five deaths due to cancers with different localizations, presenting with ulcero-budding nodular swelling of the lower palpebral conjunctiva measuring 2cm long its longer axis, gradually increasing volume over one year. It involved the inner half of the lower tarsal conjunctiva closely with the lower lacrimal punctum (A). Tumor biopsy showed well differentiated squamous carcinoma of the conjunctiva. Read More

Indian J Ophthalmol 2018 Nov;66(11):1627-1629

Department of Pediatrics, Dr Shroff's Charity Eye Hospital, New Delhi, India.

Fixed drug eruption (FDE) is a type of drug-induced cutaneous disorder that characteristically presents with recurrence of similar lesion at the same skin or mucosal site as a result of systemic exposure to a drug. Paracetamol is commonly prescribed analgesic-antipyretic agent in all age group of patients. FDE due to paracetamol is not very common but it is well reported in literature for all age groups. Read More

Indian J Ophthalmol 2018 Nov;66(11):1569-1573

Oculoplasty, Orbit and Ocular Oncology Services, Centre for Sight, Hyderabad, Telangana, India.

Purpose: To determine the role of primary limbal stem cell transplantation (LSCT) in managing extensive ocular surface squamous neoplasia (OSSN) with more than 3 quadrants of limbal involvement to prevent manifestations of limbal stem cell deficiency.

Methods: A multi-center, comparative, and interventional clinical study of cases and historical controls was done. Patients with a limbal mass suggestive of OSSN involving more than 3 quadrants of limbus (> 9 clock hours) and no local, regional or systemic metastasis, who underwent primary surgical excision with or without adjuvant chemotherapy and had a minimum follow-up of 12 months were included in this study. Read More

Sci Signal 2018 Oct 23;11(553). Epub 2018 Oct 23.

Bioscience Laboratory, BIOS Bioscience and Technology Limited Company, Guangzhou 510320, China.

In many mammals, the eyelids migrate over the eye and fuse during embryogenesis to protect the cornea from damage during birth and early life. Loss-of-function mutations affecting the epidermal growth factor receptor (EGFR) signaling pathway cause an eyes-open-at-birth (EOB) phenotype in rodents. We identified an insertional mutation in () in a strain of transgenic rats exhibiting the EOB phenotype. Read More

BMC Cancer 2018 Oct 22;18(1):1024. Epub 2018 Oct 22.

Department of Health Sciences, University of Florence, viale Pieraccini, 6, 50139, Florence, Italy.

Background: Merkel cell carcinoma (MCC) is a rare neuroendocrine malignancy of the skin characterized by high aggressiveness. Four main factors are implicated in its development: immunosuppression, ultraviolet radiation, age and the Merkel cell polyomavirus (MCPyV). In recent years, immune checkpoint inhibitors have shown clinical activity in MCC treatment. Read More

Cornea 2019 Jan;38(1):127-133

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.

Purpose: To describe an impression cytology (IC) technique using a purpose-built, sterile, EYEPRIM IC device that can be coupled with a TRIzol reagent-based RNA extraction protocol to yield sufficient RNA for gene expression analysis.

Methods: IC samples using the EYEPRIM device were collected from the bulbar conjunctiva, with and without topical anesthesia, and evaluated for RNA yield, the absence of polymerase chain reaction (PCR) inhibitors, and the ability to detect biomarkers by quantitative real-time PCR and droplet digital PCR. A technique for collecting IC samples in the clinic, while preserving RNA, and a protocol for subsequent laboratory analysis of RNA were developed. Read More

Pan Afr Med J 2018;30:80. Epub 2018 May 29.

Department of Neurosurgery, Hospital Imaculada Conceição da Sociedade Portuguesa de Beneficência, Ribeirão Preto, São Paulo, Brazil.

Medicine (Baltimore) 2018 Oct;97(42):e12676

Department of Interventional Radiology and hemangioma.

Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital.We retrospectively analyzed patients with newly diagnosed unilateral advanced intraocular (group D or E) RB undergoing IAC from October 2016 to December 2017 in our hospital. Read More

Jpn J Ophthalmol 2018 Nov 15;62(6):699-705. Epub 2018 Oct 15.

Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: Enterococcus faecalis causes severe acute endophthalmitis and often leads to poor visual outcomes. Conjunctival bacterial cultures occasionally grow atypical bacteria including E. faecalis, which can potentially contribute to the development of postoperative endophthalmitis. Read More

Asia Pac J Ophthalmol (Phila) 2018 Sep-Oct;7(5):364

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

This corrects the article DOI: 10.1097/APO.0000000000000185. Read More

Int J Med Sci 2018 30;15(12):1260-1267. Epub 2018 Jul 30.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PRC. 430030.

To investigate whether lacrimal canaliculus epithelial stem cells (LCESC) could be isolated and expanded . The lacrimal canaliculus epithelium of 6 patients with limbal stem cell deficiency (LSCD) caused by alkali burn or Stevens Johnson Syndrome were examined by lacrimal endoscope. Cadaveric eyelids were fixed and prepared for cross section and stained with HE and antibodies against PCK, Vim, p63α, SCF and c-Kit. Read More

BMC Ophthalmol 2018 Sep 29;18(1):260. Epub 2018 Sep 29.

Allergan plc, Irvine, CA, USA.

Background: International Task Force (ITF) guidelines established a grading scheme to support treatment of dry eye disease based on clinical signs and symptoms. The purpose of this study was to assess the impact of dry eye on vision-related function across ITF severity levels using the Ocular Surface Disease Index (OSDI) questionnaire.

Methods: Non-interventional, cross-sectional study of prescription treatment-naïve dry eye patients seeking symptom relief at 10 ophthalmology and optometry practices. Read More

Ocul Surf 2018 Sep 22. Epub 2018 Sep 22.

Miami VA, Veterans Affairs Medical Center, Miami, FL, USA; Bascom Palmer Eye Institute, Miller School of Medicine at the University of Miami, Miami, FL, USA. Electronic address:

Purpose: Our aim was to correlate cardiovascular risk factor estimation with bulbar conjunctival blood flow metrics as measured through Functional Slit Lamp Biomicroscopy (FSLB).

Methods: Cross-sectional study of individuals with otherwise healthy eyelid and corneal anatomy recruited from the Miami Veterans Affairs (VA) Healthcare System eye clinic. We measured conjunctival microvascular hemodynamics by mounting a camera on a slit lamp and cardiovascular risk using the Framingham risk score. Read More

Saudi Med J 2018 Sep;39(9):940-945

Department of Pathology, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia. E-mail.

Primary mucinous adenocarcinoma (PMA) of the eyelid is an exceptionally rare clinical entity. Often, it mimics with benign lesions on clinical examination and with metastatic mucinous adenocarcinoma on histological examinations. We report a case of PMA in a 60-year- old male patient who came with a slow-growing, painless swelling near the lower lid of the left eye. Read More

Indian J Ophthalmol 2018 Oct;66(10):1506-1508

Department of Orbit and Oculoplasty, Aravind Eye Hospital and Post-graduate Institute of Ophthalmology, Pondicherry, India.

Benign eyelid tumors derived from hair follicles are rare and frequently misdiagnosed as basal-cell carcinoma when evaluation is based on clinical evidence alone. The discrepancy between the clinical aspect and the histological diagnosis can be as high as 30-40%, even for experienced clinicians. Unfortunately, this masquerade is not only clinical but also histological. Read More

Indian J Ophthalmol 2018 Oct;66(10):1411-1416

Department of Ophthalmology, V.M.M.C and Safdarjung Hospital, New Delhi, India.

Purpose: To correlate the severity of meibomian gland dysfunction (MGD) with the serum lipoprotein levels.

Methods: The study was conducted as a prospective observational study over a period of 18 months. Ninety patients diagnosed with MGD were enrolled after they gave their informed consent according to the inclusion-exclusion criteria. Read More

Indian J Ophthalmol 2018 Oct;66(10):1394

Oculoplasty and Ocular Oncology Services, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

World Neurosurg 2018 Dec 18;120:382-390. Epub 2018 Sep 18.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Background: Rosai-Dorfman disease (RDD) is a benign, self-limiting, and nonneoplastic histiocytic proliferative disorder with a poorly defined pathogenesis. Central nervous system involvement is extremely rare, particularly cases with multiple intracranial masses. There is no consensus on optimal treatment and management of RDD. Read More

Ocul Surf 2018 Sep 13. Epub 2018 Sep 13.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: To investigate the differences in ocular surface characteristics, tear film parameters, and dry eye symptomology between co-located pediatric populations of Asian and Caucasian ethnicity.

Methods: Seventy New Zealand-born pediatric participants, aged between 5 and 18 years, were recruited in an age and environmentally controlled cross-sectional study. Participants were classified into three groups according to ethnicity and eyelid morphology: Asian single lid (ASL), Asian double lid (ADL), and Caucasian double lid (CDL). Read More

Cornea 2018 Nov;37 Suppl 1:S39-S41

Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.

Transplantation of the autologous cultured corneal limbal epithelium and oral mucosal epithelium is a standard technique for ocular surface reconstruction under corneal limbal stem cell deficiency. As an option for bilateral cases, we recommend utilization of autologous conjunctivae for ocular surface reconstruction. Autologous conjunctival epithelium sheet transplantation was effective for bilateral corneal limbal stem cell deficiency without symblepharon or severe keratinization. Read More

Eye Contact Lens 2019 Jan;45(1):11-18

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD.

Objectives: Ocular surface disease frequently coexists with glaucoma and may be initiated or exacerbated by topical glaucoma medications. We performed a review of current literature to assess the prevalence, causes, and treatment of ocular surface disease in glaucoma patients, specifically those on topical therapy.

Methods: A Pubmed database search was conducted. Read More

Eye Contact Lens 2018 Sep;44 Suppl 1:S110-S114

Centre for Contact Lens Research, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada.

Purpose: To quantify the strength of association of dry eye (DE) symptoms to DE diagnostic tests in age-matched females.

Methods: Twenty females with DE symptoms (Ocular Surface Disease Index, OSDI, ≥13) were age-matched with 20 females without DE symptoms (OSDI<13) in this cross-sectional study. Noninvasive tear breakup time (NIBUT), ocular staining, meibum quality, number of obstructed meibomian glands (MGs), lid wiper epitheliopathy, Marx line placement, eyelid margin score, Schirmer test, meibography, and visual acuity were assessed in both groups. Read More

BMC Ophthalmol 2018 Aug 22;18(1):206. Epub 2018 Aug 22.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No.639 ZhizaojuRoad, Shanghai, 200025, People's Republic of China.

Background: Goldenhar syndrome has variable presentations and can affect multiple regions of the body. Diagnoses are based on clinical manifestations. The association of Goldenhar syndrome with blepharophimosis and limb deformities has not previously been reported. Read More