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West Afr J Med 2022 Jun;39(6):628-634

Oral and Maxillofacial Surgery Unit, Dental and Maxillofacial Surgery Department, Aminu Kano Teaching Hospital, Kano State, Nigeria.

Background: Neurogenic tumors constitute a group of true and pseudo-tumors arising from tissues derived from embryonic neural crest cells. They are rare in the maxillofacial region.

Objectives: To analyze the demographic, clinical presentation and histopathological spectrum of neurogenic tumors of the oral and maxillofacial region seen over a 28-year period. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):718-723

Department of Otolaryngology, Guangdong Province Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, China.

To investigate the method and efficacy of reconstruction of facial skin defects after removing the lesions by applying the V-Y subcutaneous pedicle flap. A retrospective analysis was performed on 23 patients with facial reconstruction by using V-Y subcutaneous pedicle flap in the Otolaryngology Department of Guangdong Integrated Traditional Chinese and Western Medicine Hospital from March 2012 to April 2021. Patient ages ranged from 45 to 85 years old, with a mean age of 66. Read More

Middle East Afr J Ophthalmol 2021 Oct-Dec;28(4):211-215. Epub 2022 Apr 30.

Department of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Purpose: The purpose of this study is to evaluate systemic inflammation in patients with pterygium using the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and hematologic indexes of inflammation.

Methods: Thirty-one patients with primary pterygium and 31 age-and sex-matched healthy participants were enrolled in this retrospective study. The MHR, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, eosinophil-to-lymphocyte ratio, monocyte-to-eosinophil ratio, mean platelet volume-to-platelet count ratio, platelet distribution width, and red cell distribution width were compared between the two groups. Read More

Middle East Afr J Ophthalmol 2021 Oct-Dec;28(4):208-210. Epub 2022 Apr 30.

Department of Ophthalmology, Dr. Somervell Memorial CSI Medical College, Thiruvananthapuram, Kerala, India.

Purpose: Conjunctivolimbal autograft is proposed to be the best treatment for pterygium and autograft can be fixed either with sutures or without. This study was undertaken to assess and compare the efficacy of sutureless versus suture techniques for conjunctivolimbal autografting in primary pterygium.

Methods: A prospective observational study was conducted in the department of ophthalmology in a tertiary care center from March 2018 to September 2019. Read More

Ophthalmol Ther 2022 Jun 11. Epub 2022 Jun 11.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China.

Reconstruction of eyelid defects, especially the posterior lamella, remains challenging because of its anatomical complexity, functional considerations, and aesthetic concerns. The goals of eyelid reconstruction include restoring eyelid structure and function and achieving an aesthetically acceptable appearance. An in-depth understanding of the complex eyelid anatomy and several reconstructive principles are mandatory to achieve these goals. Read More

Jpn J Ophthalmol 2022 Jul 7;66(4):343-349. Epub 2022 Jun 7.

Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Purpose: To clarify the incidence and demographic characteristics of malignant eyelid tumors diagnosed in a single institute in Japan.

Study Design: Retrospective, observational case series METHODS: Patients with malignant eyelid tumors diagnosed histopathologically at Tokyo Medical University Hospital between 1995 and 2019 were reviewed retrospectively. The incidence and demographic profile of malignant eyelid tumors were analyzed. Read More

Indian J Ophthalmol 2022 Jun;70(6):1975-1981

Department of Ocular Pathology, Larson and Tourbo, Vision Research Foundation, Chennai, Tamil Nadu, India.

Purpose: To provide a retrospective analysis of lesions of the caruncle which have been very rarely reported in the literature.

Methods: A retrospective review of all the caruncular lesions between January 2000 and January 2020 was done at a single tertiary eye care hospital. The lesions were classified as benign and malignant lesions. Read More

Indian J Ophthalmol 2022 Jun;70(6):1971-1974

Department of Microbiology, Faculty of Medical Science, Niğde Ömer Halisdemir University, Niğde, Turkey.

Purpose: In this study, our aim was to investigate if fibrin adhesives used in conjunctival wound surgery with autologous conjunctival grafts could be used repeatedly at different times after surgical opening.

Methods: 40 New Zealand rabbits were used in the study. These animals were divided into four groups, each consisting of 10 rabbits, and hence 20 eyes. Read More

Klin Monbl Augenheilkd 2022 Jun 24;239(6):823-845. Epub 2022 May 24.

Conjunctival tumors result from gain of tissue, which can be either degenerative or neoplastic, but also inflammatory. In this article, degenerative (pterygium and pinguecula) as well as benign and malignant neoplastic conjunctival changes (epithelial, melanocytic and vascular tumors, choristomas as well as metastases) are discussed with regard to pathogenesis, symptoms, diagnostics and current status of treatment. Read More

BMC Ophthalmol 2022 May 23;22(1):232. Epub 2022 May 23.

Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Saudi Arabia.

Background: Intramuscular haemangiomas are rare, benign vascular tumours that represent < 1% of all haemangiomas. When involving the extraocular muscles, haemangiomas are extremely rare, with only nine cases reported in the literature; to date there are no reported cases of extraocular muscle haemangiomas extending into the brain.

Case Presentation: A 6-year-old boy with a two-week history of a painless swelling and erythema on the upper eyelid. Read More

Ophthalmic Plast Reconstr Surg 2022 May 20. Epub 2022 May 20.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.

The purpose of this report is to discuss high-pressure injection injuries involving the face and orbit and discuss factors affecting prognosis and management as these injuries are rare and uniquely challenging to manage given the complex anatomy and extensive damage that may occur. In this case, we present severe injury to the left orbit, maxillofacial region, and neck of a 29-year-old male who suffered a high-pressure diesel injection injury requiring several surgical debridements, intensive care unit (ICU) level care, and ultimately sub-total exenteration. Initial management involved systemic antibiotics, steroids, and surgical debridement; however, our patient experienced subsequent rapid deterioration resulting in admission for more aggressive subspecialty intervention. Read More

Organogenesis 2022 12;18(1):2066453

Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

The human eyelid embodies a vast diversity of functions. Acting as a protective shield for the ocular apparatus and as a light regulator in the sight process, eyelids stand a fascinating - yet omitted - role in facial aesthetics, serving as a racial trait by which humankind succeeded to manifest heterogeneity as a species. These assumptions are precisely forecasted right from in-utero life through intricate processes of growth and cell differentiation. Read More

J Mol Med (Berl) 2022 06 18;100(6):947-961. Epub 2022 May 18.

Ocular Therapeutics and Drug Delivery, Singapore Eye Research Institute, Singapore, Singapore.

Valproic acid (VPA), widely used for the treatment of neurological disorders, has anti-fibrotic activity by reducing collagen production in the postoperative conjunctiva. In this study, we investigated the capacity of VPA to modulate the postoperative collagen architecture. Histochemical examination revealed that VPA treatment was associated with the formation of thinner collagen fibers in the postoperative days 7 and 14 scars. Read More

Eye Contact Lens 2022 Jul 17;48(7):289-294. Epub 2022 May 17.

Department of Ophthalmology (G.A.A., E.A., H.K.), Adıyaman University Research and Training Hospital, Adıyaman, Turkey; Department of Ophthalmology (C.I.), Tayfur Ata Sokmen Medicine Faculty, Mustafa Kemal University, Hatay,Turkey; Department of Pathology (B.P.), Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey; and Department of Pediatric Endocrinology (S.B.), Adıyaman University Research and Training Hospital,Adıyaman, Turkey.

Purpose: The aim of this study was to investigate tear function-associated clinical findings and conjunctival histopathological changes in children with vitamin D (Vit-D) deficiency.

Methods: This study used a prospective case-control design. Group 1 (n=38) comprised pediatric patients with Vit-D deficiency, and group 2 (n=45) was the control group. Read More

Front Public Health 2022 27;10:861044. Epub 2022 Apr 27.

Centre for Ophthalmology and Visual Science (Incorporating the Lions Eye Institute), University of Western Australia, Perth, WA, Australia.

Myopia tends to develop and progress fastest during childhood, and the age of stabilization has been reported to be 15-16 years old. Thus, most studies on myopia have centered on children. Data on the refractive error profile in young adulthood - a time in life when myopia is thought to have stabilized and refractive error is unaffected by age-related pathology such as cataract - are limited. Read More

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Rotterdam Eye Hospital, Schiedamse Vest 180, 3011 BH Rotterdam, The Netherlands.

An Ocular Sebaceous Carcinoma (OSC) is a rare malignant tumor for which initial clinical and pathological diagnosis is often incorrect. OSCs can mimic Squamous Cell Carcinomas of the Conjunctiva (SCCC). The aim of this study was to find microRNA biomarkers to distinguish OSCs and SCCCs from normal tissue and from each other. Read More

Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):e80-e82. Epub 2022 Apr 4.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Squamoid eccrine ductal carcinoma (SEDC) is a rare cutaneous neoplasm that often manifests as a plaque or nodule in sun-exposed areas of older patients. Herein, the authors report the first case of SEDC in the eyelid. A 76-year-old man presented with a 2. Read More

Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):307-309. Epub 2022 May 11.

Ann Anat 2022 Aug 7;243:151954. Epub 2022 May 7.

Institute of Functional and Clinical Anatomy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address:

Objective: Urea is a component of tear fluid showing a significantly decreased concentration in dry eye disease. The urea content of tear fluid may depend on urea transporters. The purpose of this study was to examine the expression of urea transporter B (UT-B) at the ocular surface and in the lacrimal glands. Read More

J Vet Med Sci 2022 Jun 5;84(6):872-876. Epub 2022 May 5.

Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.

Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Read More

J Cosmet Dermatol 2022 May 5. Epub 2022 May 5.

Li-An Medical Clinic, Taipei City, Taiwan.

Background: Filler injection for lower eyelid rejuvenation remains a difficult subject due to many complicated anatomic changes as the face ages.

Objectives: To propose an alternative, simple, and effective filler injection method in lower eyelids for Asian patients.

Methods: Any patient who has tear trough deformities, infra-orbital hollows, nasojugal grooves, dark eye circles, as well as mild eyebags is a potential candidate for this method. Read More

Facial Plast Surg Clin North Am 2022 May;30(2):271-276

Department for Hand, Plastic and Aesthetic Surgery, Ludwig - Maximilian University Munich, Munich, Germany. Electronic address:

This study investigated eye movement patterns using eye tracking technology when looking at preoperative and postoperative images of patients that underwent bilateral periorbital cosmetic surgery. The sequence of facial recognition before surgery was periorbital-nose-perioral, whereas following surgery it was nose-periorbital-perioral. This study revealed that the sequence of facial feature recognition is influenced by the aesthetic liking of the observer and that alteration to facial features influences the sequence of facial feature recognition. Read More

J Dtsch Dermatol Ges 2022 05 2;20(5):690-693. Epub 2022 May 2.

Department of Dermatology, Dermatosurgery and Allergology, Klinikum Bremen-Ost.

Neuromuscul Disord 2022 May 27;32(5):445-449. Epub 2022 Mar 27.

Harry Perkins Institute, Centre for Medical Research, University of Western Australia, Nedlands, WA, Australia. Electronic address:

Arthrogryposis is a consequence of reduced fetal movements and arises due to environmental factors or underlying genetic defects, with extensive genetic heterogeneity. In many instances, the genes responsible are involved in neuromuscular function. Missense variants in the gene encoding embryonic myosin heavy chain (MYH3) usually cause distal arthrogryposis. Read More

Invest Ophthalmol Vis Sci 2022 04;63(4):17

Department of Ophthalmology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: The progression and recurrence of pterygium mainly occur due to the abnormal proliferation and migration of stromal pterygium fibroblasts. This research explores the aberrant expression of small nucleolar RNA U3 (U3 snoRNA) in pterygium and elucidates the molecular mechanisms of U3 snoRNA in pterygium development.

Methods: Primary human conjunctival fibroblasts (HCFs) and human pterygium fibroblasts (HPFs) were separated and cultured from fresh conjunctiva grafts and pterygium tissues. Read More

Front Biosci (Landmark Ed) 2022 04;27(4):132

Department of Ophthalmology, Henan Provincial People's Hospital, 450003 Zhengzhou, Henan, China.

Background: Cumulative evidence suggests that the risk of eye tumors varies among different age groups and populations. The purpose of the present study was to assess the age distribution of eye tumors in China.

Methods: In this retrospective study, the age distribution of various types of eye tumors was analyzed on surgically excised and histologically confirmed specimens obtained from 4492 patients (4526 eyes), collected between 2001 and 2017. Read More

J Cosmet Dermatol 2022 Apr 22. Epub 2022 Apr 22.

Department of Oculoplastic and Orbital Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Background: Treatment with hyaluronic acid (HA) fillers as a strategy for rejuvenation has experienced a significant growth in recent years, accompanied by a parallel increase in its complications, the treatment of which, such as hyaluronidase, we must be aware of.

Patients/methods: 14 patients (28 eyes) had indication for upper blepharoplasty surgery in the Hospital Universitario y Politécnico La Fe. After surgery, periocular skin of one eye of each patient was infiltrated with 300 U of hyaluronidase (14 cases) while the skin of the fellow eye was preserved untreated (14 controls). Read More

Sci Rep 2022 04 21;12(1):6545. Epub 2022 Apr 21.

Biomedical Sciences Research Institute, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.

Microvascular haemodynamic alterations are associated with coronary artery disease (CAD). The conjunctival microcirculation can easily be assessed non-invasively. However, the microcirculation of the conjunctiva has not been previously explored in clinical algorithms aimed at identifying patients with CAD. Read More

Salud Publica Mex 2022 Apr 8;64(2):209-217. Epub 2022 Apr 8.

Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra. Mexico City, Mexico.

Objective: To investigate the association of high-risk hu-man papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN).

Materials And Methods: We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consump-tion information. Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):258-261

Department of Pathology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey.

Context: p16 is an important tumor suppressor gene and responsible for regulating the cell cycle. Diffuse positivity with p16 in the cervix and head/neck carcinomas can be regarded as a surrogate marker of the presence of high-risk human papillomavirus (HPV).

Aim: The aim of our study was to search the existence of p16 expression in pterygium. Read More