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Descemet's Membrane Modulation of Posterior Corneal Fibrosis.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):1010-1020

Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.

Purpose: The purpose of this study was to evaluate the effect of removal of Descemet's basement membrane and endothelium compared with removal of the endothelium alone on posterior corneal fibrosis.

Methods: Twelve New Zealand White rabbits were included in the study. Six eyes had removal of the Descemet's membrane-endothelial complex over the central 8 mm of the cornea. Read More

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http://dx.doi.org/10.1167/iovs.18-26451DOI Listing

Retinal Microvascular Abnormalities in Children with Type 1 Diabetes Mellitus Without Visual Impairment or Diabetic Retinopathy.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):990-998

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To study the characteristics and associated factors of retinal microvascular abnormalities in children with type 1 diabetes mellitus (T1DM) without visual impairment and diabetic retinopathy (DR).

Methods: Case-control hospital-based study including children with or without DM. Optical coherence tomography angiography (OCTA; CIRRUS HD-OCT model 5000) was used to scan 6 × 6 mm square area of posterior retina and optic disc. Read More

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http://dx.doi.org/10.1167/iovs.18-25499DOI Listing

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):965-977

Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.

Purpose: Retinal ischemia, a common cause of several vision-threatening diseases, contributes to the death of retinal neurons, particularly retinal ganglion cells (RGCs). Heat shock transcription factor 1 (HSF1), a stress-responsive protein, has been shown to be important in response to cellular stress stimuli, including ischemia. This study is to investigate whether HSF1 has a role in retinal neuronal injury in a mouse model of retinal ischemia-reperfusion (IR). Read More

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http://dx.doi.org/10.1167/iovs.18-26216DOI Listing

Use of toluidine blue dye in detection of anogenital injuries in consensual sexual intercourse.

Authors:
N Hirachan

J Forensic Leg Med 2019 Feb 27;64:14-19. Epub 2019 Feb 27.

Forensic Medicine Department, Gandaki Medical College, Pokhara, Nepal. Electronic address:

The usefulness of Toluidine blue dye in the detection of anogenital injuries in sixty females aged 16-40 years of age with a history of consensual sexual intercourse within 48 h of intercourse were included for the study from the Gynaecology outpatient department of the Institute of Medicine, Maharajgunj, Kathmandu, Nepal over a period of 10 months. Injuries were identified and documented using TEARS classification (tears-ecchymosis-abrasion-redness-swelling) before and after the application of toluidine blue dye (TBD). Anogenital injuries were detected in 6. Read More

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http://dx.doi.org/10.1016/j.jflm.2019.02.006DOI Listing
February 2019

Performance of four models for eye color prediction in an Italian population sample.

Forensic Sci Int Genet 2019 Mar 11;40:192-200. Epub 2019 Mar 11.

Department of Biology, University of Padova, Padova, Italy. Electronic address:

Forensic DNA phenotyping (FDP) has recently provided important advancements in forensic investigations, by predicting the physical appearance of a subject from a biological sample, using SNP markers. The majority of operable prediction models have been developed for iris color; however, replication studies to understand their applicability on a worldwide scale are still limited for many of them. In this work, 4 models for eye color prediction (IrisPlex, Ruiz, Allwood and Hart models) were systematically evaluated in a sample of 296 subjects of Italian origin. Read More

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http://dx.doi.org/10.1016/j.fsigen.2019.03.008DOI Listing

Transscleral sutureless intraocular lens versus retropupillary iris-claw lens fixation for paediatric aphakia without capsular support: a randomized study.

Acta Ophthalmol 2019 Mar 18. Epub 2019 Mar 18.

Department of Ophthalmology, Cairo University Hospital, Cairo, Egypt.

Purpose: To compare results of sutureless transscleral intraocular lens (IOL) fixation to retropupillary iris-claw lens implantation in cases of paediatric aphakia without capsular support.

Methods: Thirty eyes of children with insufficient capsular support for IOL implantation were randomized to undergo sutureless transscleral IOL fixation or iris-claw lens fixation. The primary outcome was best-corrected visual acuity (BCVA). Read More

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http://dx.doi.org/10.1111/aos.14090DOI Listing

Germline large deletion of BAP1 and decreased expression in non-tumor choroid in uveal melanoma patients with high risk for inherited cancer.

Genes Chromosomes Cancer 2019 Mar 18. Epub 2019 Mar 18.

Department of Ophthalmology and Visual Science, Havener Eye Institute, The Ohio State University Columbus, Ohio.

Uveal melanoma (UM) is the most common phenotype in patients with germline BAP1 mutation. This study aimed to identify selection criteria for BAP1 germline testing and assessed the role of large deletion/duplication and epigenetic inactivation. 172 UM patients with high risk of hereditary cancer were included. Read More

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http://dx.doi.org/10.1002/gcc.22752DOI Listing

Application of eye tracking as a user interface for urological surgery.

Int J Urol 2019 Mar 18. Epub 2019 Mar 18.

Department of Urology, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1111/iju.13949DOI Listing

Retinal and circulating miRNA expression patterns in diabetic retinopathy: an in silico and in vivo approach.

Br J Pharmacol 2019 Mar 18. Epub 2019 Mar 18.

Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.

Background And Purpose: Diabetic retinopathy, a secondary complication of diabetes mellitus, can lead to irreversible vision loss. Currently, no treatment is approved for early phases of diabetic retinopathy. Modifications of the expression pattern of miRNAs could be involved in the early retinal damage of diabetic subjects. Read More

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http://dx.doi.org/10.1111/bph.14665DOI Listing

GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma.

PLoS One 2019 18;14(3):e0214073. Epub 2019 Mar 18.

Department of Ophthalmology, Weifang People's Hospital, Weifang, China.

Growth differentiation factor 11 (GDF11), is a member of the transforming growth factor-beta (TGF-β) superfamily and bone morphogenetic protein (BMP) subfamily. In this study, we aimed to assess the expression profile of GDF11, its prognostic value in terms of OS, as well as the potential mechanisms leading to its dysregulation in uveal melanoma. A retrospective study was conducted using our primary data and genetic, clinicopathological and overall survival (OS) data from the Cancer Genome Atlas-Uveal Melanoma (TCGA-UVM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214073PLOS

Ocular Point-of-Care Ultrasound in the Pediatric Emergency Department.

Pediatr Emerg Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatric Emergency Medicine, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Objective: Point-of-care ultrasound has become an important adjunct for diagnostic assessment in pediatric emergency medicine. In this case series, we demonstrate how ocular point-of-care ultrasound is used to correctly diagnose ocular pathologies and to expedite care.

Methods/results: We present a series of cases in which the point-of-care ultrasound ocular examination proved valuable in the timely diagnosis of pathologies involving the lens, vitreous, retina, and retrobulbar segment of the eye. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001762DOI Listing
February 2019

CHOROIDAL NEVUS TRANSFORMATION INTO MELANOMA PER MILLIMETER INCREMENT IN THICKNESS USING MULTIMODAL IMAGING IN 2355 CASES: The 2019 Wendell L. Hughes Lecture.

Retina 2019 Mar 15. Epub 2019 Mar 15.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Dr. Dalvin has an appointment at the Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Purpose: To analyze risk of nevus transformation into melanoma per millimeter increment.

Methods: Retrospective analysis of 3,806 choroidal nevi for transformation into melanoma per incremental millimeter thickness (flat [≤1.0 mm], thin [1. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002508DOI Listing

POSTERIORLY INSERTED VITREOUS BASE: Preoperative Characteristics, Intraoperative Findings, and Outcomes After Vitrectomy.

Retina 2019 Feb 15. Epub 2019 Feb 15.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To determine the preoperative characteristics, intraoperative and postoperative complications, and outcomes of eyes with posteriorly inserted vitreous base.

Methods: In this retrospective, observational, consecutive case series at 2 academic centers, 37 patients were studied who had posteriorly inserted vitreous base noted during vitrectomy. Posteriorly inserted vitreous base was defined as the insertion of the posterior hyaloid membrane being located posterior to the vortex veins. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002482DOI Listing
February 2019

Correspondence.

Authors:
Mohammad Zarei

Retina 2019 Feb 15. Epub 2019 Feb 15.

Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1097/IAE.0000000000002478DOI Listing
February 2019

Modification of the Neuropathic Pain Symptom Inventory for use in eye pain (NPSI-Eye).

Pain 2019 Mar 15. Epub 2019 Mar 15.

Miami Veterans Administration Medical Center, Miami, FL.

Chronic eye pain, which has previously been assumed to be due to ocular surface abnormalities (i.e., "dry eye disease"), has recently garnered attention as a potential indicator of neuropathic ocular pain in some patients. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001552DOI Listing

Eye Movements, Dizziness, and Mild Traumatic Brain Injury (mTBI): A Topical Review of Emerging Evidence and Screening Measures.

J Neurol Phys Ther 2019 Apr;43 Suppl 2 Supplement, Special Supplement: International Conference on Vestibular Rehabilitation:S31-S36

University of Pittsburgh, Pittsburgh, Pennsylvania.

Background And Purpose: Eye movements may be adversely affected after mild traumatic brain injury (mTBI) and should be examined. The purpose of this topical review is to provide the clinician with the most up-to-date knowledge related to eye movement abnormalities, screening measures, and evidence related to exercise interventions that are designed to enhance outcomes in persons after mTBI.

Summary Of Key Points: Presence of eye misalignment such as tropias or phoria or symptoms with head/eye movements such as vestibulo-ocular reflex (VOR) × 1, saccades, or smooth pursuits may slow the person's recovery. Read More

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http://dx.doi.org/10.1097/NPT.0000000000000272DOI Listing

Ocular Misalignment in Dizzy Patients-Something's A-Skew.

J Neurol Phys Ther 2019 Apr;43 Suppl 2 Supplement, Special Supplement: International Conference on Vestibular Rehabilitation:S27-S30

Departments of Neurology, Ophthalmology, Neurosurgery, Otolaryngology-Head and Neck Surgery, and Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland (D.R.G.); and Laboratory of Vestibular Neuroadaptation, Departments of Otolaryngology-Head and Neck Surgery and Physical Medicine and Rehabilitation, Johns Hopkins University, School of Medicine, Baltimore, Maryland (M.C.S.).

Background And Purpose: Both central (eg, brain stem, cerebellum) and peripheral (eg, vestibular, fourth cranial nerve palsy) etiologies can cause a vertical misalignment between the eyes with a resultant vertical diplopia. A vertical binocular misalignment may be due to a skew deviation, which is a nonparalytic vertical ocular misalignment due to roll plane imbalance in the graviceptive pathways. A skew deviation may be 1 component of the ocular tilt reaction. Read More

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http://dx.doi.org/10.1097/NPT.0000000000000271DOI Listing

Approach to the Examination and Classification of Nystagmus.

Authors:
Scott D Z Eggers

J Neurol Phys Ther 2019 Apr;43 Suppl 2 Supplement, Special Supplement: International Conference on Vestibular Rehabilitation:S20-S26

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Background And Purpose: Physical therapists caring for patients with neurologic or vestibular disorders must routinely examine and characterize nystagmus and other oscillatory eye movements. Often, the diagnosis hinges on proper interpretation of the nystagmus pattern. This requires understanding the terminology surrounding the numerous attributes and influencing factors of nystagmus, a systematic approach to the examination, and a classification structure that guides practitioners to the specific nystagmus type and subsequent evaluation and management. Read More

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http://dx.doi.org/10.1097/NPT.0000000000000270DOI Listing

Incremental Vestibulo-ocular Reflex Adaptation Training Dynamically Tailored for Each Individual.

J Neurol Phys Ther 2019 Apr;43 Suppl 2 Supplement, Special Supplement: International Conference on Vestibular Rehabilitation:S2-S7

Balance and Vision Laboratory (C.J.T., W.V.C.F., A.A.M.), Neuroscience Research Australia, Sydney, New South Wales, Australia; University of New South Wales (A.A.M.), Sydney, New South Wales, Australia; Laboratory of Vestibular NeuroAdaptation (M.C.S.), Department of Otolaryngology-Head and Neck Surgery (A.A.M.), Johns Hopkins University, Baltimore, Maryland; Department of Physical Medicine and Rehabilitation (M.C.S.), Johns Hopkins University, Baltimore, Maryland.

Background And Purpose: Unilateral incremental vestibulo-ocular reflex (VOR) adaptation (IVA) increases the VOR gain (= eye/head velocity) for head rotations to one side by ∼10%. Prior IVA studies involved setting the initial VOR training gain demand at the subject's starting value (= 1 in a healthy subject), with the gain preset to increment by 0.1 every 90 seconds over 15 minutes, defined as Static IVA. Read More

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http://dx.doi.org/10.1097/NPT.0000000000000269DOI Listing

NOVEL APPROACH TO SCLERAL FIXATION OF A REPER INTRAOCULAR LENS AND ARTIFICIAL IRIS COMPLEX FOLLOWING PARS PLANA LENSECTOMY AND VITRECTOMY FOR ECTOPIA LENTIS AND CATARACT IN A PATIENT WITH ANIRIDIA AND NYSTAGMUS.

Retin Cases Brief Rep 2019 Mar 14. Epub 2019 Mar 14.

Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.

Purpose: Prosthetic iris devices have recently been used to improve cosmesis and reduce glare in aniridia. There is currently no consensus on which prosthetic iris device or which surgical approach is preferred for managing large iris defects.

Methods: A novel surgical approach with Gore-Tex polytetrafluoroethylene sutures was used to achieve scleral fixation of an intraocular lens and artificial iris complex in a 19-year-old Caucasian female patient with aniridia, nystagmus, cataracts, and ectopia lentis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000863DOI Listing

Translational research.

Curr Opin Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

MidAtlantic Retina, The Retina Service of Wills Eye Hospital, Philadelphia, Pennsylvanial.

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http://dx.doi.org/10.1097/ICU.0000000000000565DOI Listing

Advances in dry eye disease treatment.

Curr Opin Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Scheie Eye Institute, University of Pennsylvania, Philadelphia, USA.

Purpose Of Review: The prevalence and burden of dry eye disease continues to grow at a rapid pace, creating an increased need for new therapies. In a sector once limited to only a handful of treatments, clinicians now have multiple options available for patients who fail traditional therapies. This review summarizes the various treatment options available to clinicians treating complex dry eye disease patients. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000569DOI Listing

Precision medicine to prevent glaucoma-related blindness.

Curr Opin Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Department of Ophthalmology and Visual Sciences, WK Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.

Purpose Of Review: Approximately 10% of patients become blind despite using evidence-based guidelines developed from clinical trials and epidemiology studies. Our purpose is to review opportunities to decrease glaucoma-related blindness using the emerging principles of precision medicine.

Recent Findings: The current review focuses on three topics: first, candidate biomarkers for angle-based surgeries, second, head-mounted display (HMD) technology for vision and testing, and third, glaucoma risk alleles discovered by genome-wide association studies. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000564DOI Listing

Endoresection utilizing pars plana vitrectomy for benign and malignant intraocular tumors.

Curr Opin Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Tennessee Retina, Nashville, TN, USA.

Purpose Of Review: Endoresection of intraocular tumors is a complicated procedure utilizing pars plana vitrectomy techniques. Though it has potential downsides and complications, there is potential for this technique in the treatment of malignant and benign intraocular tumors.

Recent Findings: Endoresection has been utilized in some form for the last three decades, but recent advances in vitreoretinal surgery have improved the technique. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000561DOI Listing

Introduction to hypersonic vitrectomy.

Curr Opin Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Bausch & Lomb, Rochester, New York, USA.

Purpose Of Review: To review the development of hypersonic vitrectomy and present the first case series in the United States.

Recent Findings: From 27 September 2017 to 4 December 2017, 64 patients underwent hypersonic vitrectomy with 20 patients having conventional 23-ga vitrectomy for comparison. The preoperative diagnoses ranged from vitreous opacities to rhegmatogenous retinal detachments. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000563DOI Listing

Glymphatic System Function in Relation to Anesthesia and Sleep States.

Anesth Analg 2019 Apr;128(4):747-758

Laboratory for Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

The brain is one of the most metabolically active organs in the body. The brain's high energy demand associated with wakefulness persists during rapid eye movement sleep, and even during non-rapid eye movement sleep, cerebral oxygen consumption is only reduced by 20%. The active bioenergetic state parallels metabolic waste production at a higher rate than in other organs, and the lack of lymphatic vasculature in brain parenchyma is therefore a conundrum. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004069DOI Listing

Ophthalmology-Based Neuropathology Risk Factors: Diabetic Retinopathy is Associated with Deep Microinfarcts in a Community-Based Autopsy Study.

J Alzheimers Dis 2019 Mar 11. Epub 2019 Mar 11.

Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Background: The aging eye offers unique opportunities to study and understand the aging brain, in particular related to Alzheimer's disease (AD) and dementia. However, little is known about relationships between eye diseases and dementia-related neurodegeneration.

Objective: To determine the potential association between three age-related eye diseases and AD and dementia-related neuropathology. Read More

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http://dx.doi.org/10.3233/JAD-181087DOI Listing

Multiple Timescale Online Learning Rules for Information Maximization with Energetic Constraints.

Neural Comput 2019 Mar 18:1-37. Epub 2019 Mar 18.

Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, 63130, U.S.A.

A key aspect of the neural coding problem is understanding how representations of afferent stimuli are built through the dynamics of learning and adaptation within neural networks. The infomax paradigm is built on the premise that such learning attempts to maximize the mutual information between input stimuli and neural activities. In this letter, we tackle the problem of such information-based neural coding with an eye toward two conceptual hurdles. Read More

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http://dx.doi.org/10.1162/neco_a_01182DOI Listing

Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa.

Drug Deliv 2019 Dec;26(1):237-243

a Department of Biomedical and Biotechnological Sciences, School of Medicine , University of Catania , Catania , Italy.

Myriocin is an antibiotic derived from Mycelia sterilia, and is a potent inhibitor of serine palmitoyltransferase, the enzyme involved in the first step of sphingosine synthesis. Myriocin, inhibiting ceramide synthesis, has a great potential for treatment of diseases characterized by high ceramide levels in affected tissues, such as retinitis pigmentosa (RP). Drug delivery to the retina is a challenging task, which is generally by-passed through intravitreal injection, that represents a risky invasive procedure. Read More

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http://dx.doi.org/10.1080/10717544.2019.1574936DOI Listing
December 2019

Recognition of incidentally learned visual search arrays is supported by fixational eye movements.

J Exp Psychol Learn Mem Cogn 2019 Mar 18. Epub 2019 Mar 18.

Department Psychologie.

Repeated encounter of abstract target-distractor letter arrangements leads to improved visual search for such displays. This contextual-cueing effect is attributed to incidental learning of display configurations. Whether observers can consciously access the memory underlying the cueing effect is still a controversial issue. Read More

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http://dx.doi.org/10.1037/xlm0000702DOI Listing

Repeatability of wide-field choroidal thickness measurements using enhanced-depth imaging optical coherence tomography.

Clin Exp Optom 2019 Mar 18. Epub 2019 Mar 18.

Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: To examine the repeatability of choroidal thickness measurements across a 55° field, in a sample of healthy young adults using wide-field enhanced-depth imaging optical coherence tomography.

Methods: High-resolution wide-field volumetric enhanced-depth imaging scans were obtained from the right eye of 27 adults (mean age 27 ± 5 years) during two sessions, separated by 19 ± 15 days, using the follow-up feature of the Spectralis instrument, while controlling for confounding factors known to influence choroidal thickness. Semi-automatic segmentation of the choroidal boundaries was corrected by a single masked observer. Read More

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http://dx.doi.org/10.1111/cxo.12893DOI Listing

Combined Ab-externo Cyclopexy and Cryopexy in Cyclodialysis Cleft Repair.

J Glaucoma 2019 Mar 13. Epub 2019 Mar 13.

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles.

Purpose: To evaluate outcomes of an ab-externo surgical technique combining cyclopexy with partial-thickness scleral flap dissection and suture reattachment of ciliary muscle and cryopexy through partial-scleral bed for cyclodialysis cleft repair.

Methods: Consecutive patients in a tertiary academic practice with cyclodialysis cleft confirmed by gonioscopy or ultrasound biomicroscopy and had received the combined procedure were reviewed. Primary outcomes included differences between the preoperative and postoperative best-corrected visual acuity (BCVA) and intraocular pressure (IOP). Read More

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http://dx.doi.org/10.1097/IJG.0000000000001239DOI Listing

Glaucoma Patient Knowledge, Perceptions, and Predispositions for Telemedicine.

J Glaucoma 2019 Mar 13. Epub 2019 Mar 13.

Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: The purpose was to identify factors associated with older glaucoma patients' knowledge of, perceptions of, and predispositions for telemedicine use.

Methods: Established patients age ≥60 years with a diagnosis of primary open angle glaucoma, glaucoma suspect, or ocular hypertension followed by a glaucoma fellowship-trained ophthalmologist were enrolled in the study at an academic, urban, tertiary referral eye clinic. Enrolled patients were administered a Life Space questionnaire (LSQ), scored 0-9, and Preferences for Telemedicine questionnaire (PTQ), a Likert scale validated tool. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001238DOI Listing

Frequencies of Four Distinct Patterns of Glaucomatous Disc Appearance and Their Clinical Associations in Japanese Population-Based Studies.

J Glaucoma 2019 Mar 13. Epub 2019 Mar 13.

Department of Ophthalmology, Gifu University Graduate School of Medicine Gifu, Japan.

Purpose: To study the frequencies and factors associated with four disc patterns in primary open-angle glaucoma (POAG) identified in population-based studies: focal glaucomatous (FG type), generalized enlargement of cup (GE type), myopic glaucomatous (MG type), and senile sclerotic glaucomatous (SS type) patterns.

Subjects: Two hundred and seventy disc photographs of acceptable quality were extracted from the records of 270 definitive POAG cases diagnosed according to the International Society of Geographical and Epidemiological Ophthalmology Criteria in two Japanese population-based glaucoma surveys. One randomly chosen eye from the bilateral POAG cases was included. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001240DOI Listing

Early Phacoemulsification After Acute Angle Closure in Patients With Coexisting Cataract.

J Glaucoma 2019 Mar 13. Epub 2019 Mar 13.

University Eye Clinic Maastricht, Maastricht University Medical Center+, Maastricht, the Netherlands.

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http://dx.doi.org/10.1097/IJG.0000000000001244DOI Listing

A Lower-limb Skin Lesion in a 10-year-old Girl.

Pediatr Infect Dis J 2019 Apr;38(4):e79

From the Sydney Children's Hospital, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1097/INF.0000000000002127DOI Listing

A case report of an extranodal NK/T-cell lymphoma nasal type, occurring primarily in eyes with masquerade syndrome.

Medicine (Baltimore) 2019 Mar;98(11):e14836

Department of Ophthalmology, The Second Xiangya Hospital.

Rationale: Extranodal natural killer T-cell lymphoma nasal type (ENKL) is an extremely rare tumor with a very low survival rate. In recent decades, only a few ENKL cases have been published. Presenting a special ENKL case lead the authors to emphasize the primary features of ENKL in early diagnosis and therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014836DOI Listing

Bilateral congenital macular coloboma and cataract: A case report.

Medicine (Baltimore) 2019 Mar;98(11):e14803

Department of Ophthalmology, Weifang Eye Hospital, Weifang, Shandong, PR China.

Rationale: The case with congenital macular coloboma and cataract was rarely reported, and the pathogenic gene of the disease is still not clear. Moreover, it is difficult to improve the visual acuity of the eye with this disease.

Patient Concerns: An 11-year-old boy presented low visual acuity and horizontal nystagmus in both eyes. Read More

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http://dx.doi.org/10.1097/MD.0000000000014803DOI Listing

Clinical classification and individualized design for the treatment of basicranial artery injuries.

Medicine (Baltimore) 2019 Mar;98(11):e14732

Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

This study aims to explore the principles of clinical classification and individualized treatment of basicranial artery injuries based on its anatomical correlation.The data of 172 patients with various types of basicranial artery injuries were retrospectively analyzed. Among these patients, 128 patients were male and 44 patients were female, and the average age of these patients was 28. Read More

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http://dx.doi.org/10.1097/MD.0000000000014732DOI Listing

Doxycycline Injection for Sclerotherapy of Lower Eyelid Festoons and Malar Edema: Preliminary Results.

Ophthalmic Plast Reconstr Surg 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology, New York University Langone Medical Center, New York, New York.

Purpose: To investigate the safety and efficacy of direct, intralesional doxycycline hyclate injection for improving the appearance of cosmetically significant lower eyelid festoons and malar edema.

Methods: An Institutional Review Board approved, retrospective review was performed of 15 consecutive patients with malar edema and/or festoons injected with doxycycline hyclate at a concentration of 10 mg/ml. Pre- and postinjection photographs were reviewed and graded on a scale of 0 to 3 (0: no festoon; 1: small festoon; 2: medium festoon; 3: large festoon) by 2 masked physician observers. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001332DOI Listing

Ocular Adnexal Racemose Cysticercosis Masquerading as Dermoid Cyst.

Ophthalmic Plast Reconstr Surg 2019 Mar 12. Epub 2019 Mar 12.

Ophthalmic Plastic Surgery Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.1097/IOP.0000000000001365DOI Listing

Altered Surfactant Protein Expression in Primary Acquired Nasolacrimal Duct Obstruction.

Ophthalmic Plast Reconstr Surg 2019 Mar 12. Epub 2019 Mar 12.

Institute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-Nürnberg, Germany.

Purpose: To investigate the presence and distribution patterns of 6 surfactant proteins in lacrimal drainage tissues of patients with primary acquired nasolacrimal duct (NLD) obstruction.

Methods: The presence and distribution of surfactant proteins (SP)-G and SP-H was first assessed in normal cadaveric lacrimal systems. The study was then performed in 10 samples of lacrimal sac and the respective NLDs obtained from patients suffering from primary acquired NLD obstruction who underwent either a dacryocystorhinostomy or a dacryocystectomy. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001372DOI Listing

Giant Dacryocele in a Setting of Bilateral Congenital Alacrimia With Punctal and Canalicular Agenesis.

Ophthalmic Plast Reconstr Surg 2019 Mar 14. Epub 2019 Mar 14.

Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Vijayawada, Andhra Pradesh, India.

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http://dx.doi.org/10.1097/IOP.0000000000001317DOI Listing

Comparison of four Combined Procedures for Correction of Involutional Lower Eyelid Entropion.

J Craniofac Surg 2019 Mar 12. Epub 2019 Mar 12.

Royal Eye Infirmary, Derriford Hospital, Plymouth, UK.

Background: To evaluate 4 combined techniques for entropion repair which address the horizontal laxity by either lateral tarsal strip (LTS) or Bick's procedure (BP) and the vertical laxity by everting sutures (ESs) or lower lid retractor plication (LLRP).

Methods: Retrospective, comparative consecutive clinical series. A total of 261 procedures were performed on 227 patients. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005466DOI Listing

Fibrin Glue-Assisted Closure of Macroperforation in Predescemetic Deep Anterior Lamellar Keratoplasty With a Donor Obtained From Small Incision Lenticule Extraction.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Dr. Agarwal's Refractive and Cornea Foundation (DARCF), Chennai, India.

Purpose: To report a case with multiple macroperforations and a double anterior chamber (AC) after predescemetic deep anterior lamellar keratoplasty.

Methods: A patient was referred after undergoing complicated excision of pseudopterygium that extended onto the cornea. At presentation, an eccentric lamellar patch graft extending over the pupillary axis with a double AC was seen. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001918DOI Listing

Peripheral Endothelial Cell Density in Descemet Membrane Endothelial Keratoplasty Grafts.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN.

Purpose: To compare the variation in corneal endothelial cell density (ECD) from the center to the periphery in unpeeled and peeled donor corneas and to determine the impact of eccentric trephining on total endothelial cells in Descemet membrane endothelial keratoplasty (DMEK) grafts.

Methods: Mated donor cornea pairs were obtained. One cornea from each pair was peeled for DMEK, whereas the other was left unpeeled. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001925DOI Listing

Outcomes of a Modified Technique for Successful Pneumatic Dissection in Pediatric Eyes With Corneal Scars.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Ospedali Privati Forlì, Department of Ophthalmology, Forlì, Italy.

Purpose: To report the outcomes of a modified deep anterior lamellar keratoplasty (DALK) procedure for the treatment of scarred corneas in otherwise healthy pediatric eyes.

Methods: All pediatric eyes undergoing DALK by the same surgeon (M.B. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001924DOI Listing

Blood Vessels and Lymphatic Vessels in the Cornea and Iris After Penetrating Keratoplasty.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.

Purpose: To detect early growth of blood and lymphatic vessels in the mouse cornea and iris after penetrating keratoplasty.

Methods: Penetrating keratoplasty was performed with C57BL/6 mice as donors and BALB/c mice as recipients. Graft transparency and neovascularization were examined by slit-lamp microscopy. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001922DOI Listing
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