669,687 results match your criteria Eyeball


Online detection of movement during natural and self-initiated reach-and-grasp actions from EEG signals.

J Neural Eng 2021 Jun 15. Epub 2021 Jun 15.

Institute of Neural Engineering, Graz University of Technology, Stremayrgasse 16/IV, Graz, Steiermark, 8010, AUSTRIA.

Movement intention detection using electroencephalography (EEG) is a challenging but important component of brain-computer interfaces (BCIs) for people with motor disabilities. Objective​: The goal of this study is to exploit low-frequency time-domain EEG signals, concretely movement-related cortical potentials (MRCPs), to perform asynchronous online detection of movement. The experimental paradigm must be easily transferable to people without any residual upper-limb movement function. Read More

View Article and Full-Text PDF

Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis.

Neuroimage Clin 2021 Jun 6;31:102715. Epub 2021 Jun 6.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, China. Electronic address:

Pinpointing the brain dysconnectivity in idiopathic rapid eye movement sleep behaviour disorder (iRBD) can facilitate preventing the conversion of Parkinson's disease (PD) from prodromal phase. Recent neuroimage investigations reported disruptive brain white matter connectivity in both iRBD and PD, respectively. However, the intrinsic process of the human brain structural network evolving from iRBD to PD still remains largely unknown. Read More

View Article and Full-Text PDF

Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies.

Neurobiol Aging 2021 May 14;105:252-261. Epub 2021 May 14.

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

We investigated whether cerebrovascular disease contributes to neurodegeneration and clinical phenotype in dementia with Lewy bodies (DLB). Regional cortical thickness and subcortical gray matter volumes were estimated from structural magnetic resonance imaging (MRI) in 165 DLB patients. Cortical and subcortical infarcts were recorded and white matter hyperintensities (WMHs) were assessed. Read More

View Article and Full-Text PDF

Effect of Sleep-Disordered Breathing During Rapid Eye Movement Sleep and Non-Rapid Eye Movement sleep on Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2021 Jun 12;30(8):105913. Epub 2021 Jun 12.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Department of Neurology, Taicang Affiliated Hospital of Soochow University, The first People's Hospital of Taicang, Taicang 215400, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address:

Objectives: Sleep-disordered breathing adversely impacts stroke outcomes. We investigated whether sleep-disordered breathing during rapid eye movement sleep and non-rapid eye movement sleep differentially influenced stroke outcomes.

Materials And Methods: Acute ischemic stroke patients who finished polysomnography within 14 days of stroke onset from April 2010 to August 2018 were reviewed. Read More

View Article and Full-Text PDF

Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test.

J Neurol Sci 2021 Jun 3;427:117529. Epub 2021 Jun 3.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. Electronic address:

Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0. Read More

View Article and Full-Text PDF

Cynaroside protects the blue light-induced retinal degeneration through alleviating apoptosis and inducing autophagy in vitro and in vivo.

Phytomedicine 2021 Jul 24;88:153604. Epub 2021 May 24.

State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China. Electronic address:

Background: Blue light can directly penetrate the lens and reach the retina to induce retinal damage, causing dry age-related macular degeneration (dAMD). Cynaroside (Cyn), a flavonoid glycoside, was proved to alleviate the oxidative damage of retinal cells in vitro. However, whether or not Cyn also exerts protective effect on blue light-induced retinal degeneration and its mechanisms of action are unclear. Read More

View Article and Full-Text PDF

Population-based utility of van Herick grading for angle closure detection.

Ophthalmology 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA 02114. Electronic address:

We report the sensitivity and specificity of van Herick (VH) grading in detecting gonioscopically-defined primary angle closure suspects (PACS) among subjects screened for participation in a population-based trial in southern China. A cut-off of VH≤25% was found to have sensitivity and specificity rates of 98.2% and 25. Read More

View Article and Full-Text PDF

Attention orienting to the eyes in violent female and male offenders: An eye-tracking study.

Biol Psychol 2021 Jun 12:108136. Epub 2021 Jun 12.

University of Tübingen, Department of Clinical Psychology and Psychotherapy, Tübingen, Germany; University Hospital Tübingen, Department of Psychiatry and Psychotherapy, Tübingen, Germany.

Attention to the eyes and eye contact form an important basis for the development of empathy and social competences including prosocial behavior. Thus, impairments in attention to the eyes of an interaction partner might play a role in the etiology of antisocial behavior and violence. For the first time, the present study extends investigations of eye gaze to a large sample (N = 173) including not only male but also female violent offenders and a control group. Read More

View Article and Full-Text PDF

Identification of Prognostic alternative splicing signatures and their clinical significance in uveal melanoma.

Exp Eye Res 2021 Jun 12:108666. Epub 2021 Jun 12.

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Electronic address:

As a posttranscriptional regulatory mechanism, alternative splicing (AS) has the potential to generate a large amount of protein diversity from limited genes. The purpose of our study was to assess the usefulness of prognostic splicing events as novel diagnostic and therapeutic signatures for uveal melanoma (UM). The datasets, clinical traits and AS data of UM were obtained from The Cancer Genome Atlas (TCGA) database and TCGA SpliceSeq database. Read More

View Article and Full-Text PDF

Effective elastic modulus of an intact cornea related to indentation behavior: A comparison between the Hertz model and Johnson-Kendall-Roberts model.

Exp Eye Res 2021 Jun 12;209:108670. Epub 2021 Jun 12.

College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China; State Key Lab. of Traction Power, Southwest Jiaotong University, Chengdu, China. Electronic address:

In this study, a macro-indentation test on the submillimeter scale was performed to analyze the indentation behavior of an intact cornea under physiological pressures. The Hertz and Johnson-Kendall-Roberts (JKR) models were employed to solve the elastic modulus (E) of the intact cornea. The relevant detailed analysis showed that the JKR model, which accounted for the contribution from the adhesion energy, could be used to obtain the E values that were more than two-folds of those obtained from the Hertz model, which only considered the external force. Read More

View Article and Full-Text PDF

Transgenerational plasticity in the eye size of .

Biol Lett 2021 Jun 16;17(6):20210143. Epub 2021 Jun 16.

Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.

It is well established that environmental signals can induce phenotypic responses that persist for multiple generations. The induction of such 'transgenerational plasticity' (TGP) depends upon the ability of organisms to accurately receive and process information from environmental signals. Thus, sensory systems are likely intertwined with TGP. Read More

View Article and Full-Text PDF

Time-Driven Activity-Based Costing for Cataract Surgery in Canada: The Case of the Kensington Eye Institute.

Healthc Policy 2021 May;16(4):97-108

Director, Health System Strategy, Medtronic ULC, Brampton, ON.

Time-driven activity-based costing (TDABC) has received considerable attention globally as a way to measure value in healthcare systems. This study aimed to apply TDABC for cataract surgery at the Kensington Eye Institute (KEI). During a field evaluation, a detailed process map was created for cataract surgery at KEI. Read More

View Article and Full-Text PDF

Factors Driving Rapid Adoption of Telemedicine in an Academic Orthopedic Surgery Department.

Telemed J E Health 2021 Jun 15. Epub 2021 Jun 15.

Department of Orthopedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Read More

View Article and Full-Text PDF

Homogeneous Visual and Fluorescence Detection of Circulating Tumor Cells in Clinical Samples Selective Recognition Reaction and Enzyme-Free Amplification.

ACS Nano 2021 Jun 15. Epub 2021 Jun 15.

Department of Laboratory Medicine, State Key Laboratory of Biotherapy and Cancer Center, Med+X Center for Manufacturing, West China Precision Medicine Industrial Technology Institute, Department of Urology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.

Here we report a simple all-nucleic-acid enzyme-free catalyzed hairpin assembly assisted amplification strategy with quantum dots (QDs) as the nanoscale signal reporter for homogeneous visual and fluorescent detection of A549 lung cancer cells from clinical blood samples. This work was based on the phenomenon that CdTe QDs can selectively recognize Ag and C-Ag-C and by using mucin 1 as the circulating tumor cells (CTCs) marker and aptamer as the recognition probe. Under optimized conditions, the limits of detections as low as 0. Read More

View Article and Full-Text PDF

Neovascular age-related macular degeneration at treatment intervals of 14 weeks or greater.

Clin Exp Ophthalmol 2021 Jun 15. Epub 2021 Jun 15.

Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Background: We assessed the proportion of eyes with neovascular age-related macular degeneration (nAMD) in routine clinical practice that reach ≥14 week treatment intervals and their outcomes.

Method: We analysed data from the Fight Retinal Blindness! (FRB!) Project database, a prospectively designed registry of "real-world" outcomes. Treatment-naive eyes starting vascular endothelial growth factor (VEGF) inhibitors for nAMD from 1 January 2006 were included. Read More

View Article and Full-Text PDF

Neuropathic Corneal Pain Following LASIK Surgery: A Retrospective Case Series.

Ophthalmol Ther 2021 Jun 15. Epub 2021 Jun 15.

HDR Research Center, Hoopes Vision, University of Utah Health Sciences Center, 11820 S. State Street Suite #200, Draper, UT, 84020, USA.

Introduction: Transient dry eye symptoms have been reported following laser in situ keratomileusis (LASIK). Very rarely, patients may present with debilitating symptoms of dry eye syndrome (DES) with limited or no evidence of ocular surface disease. These patients are diagnosed with a form of DES known as neuropathic corneal pain (NCP). Read More

View Article and Full-Text PDF

A Novel Multi-Ingredient Supplement Reduces Inflammation of the Eye and Improves Production and Quality of Tears in Humans.

Ophthalmol Ther 2021 Jun 15. Epub 2021 Jun 15.

G7 Synergon Private Limited, 537, 5th Main, 9th Cross, Sahakarnagar Post, Tatanagar, Bangalore, Karnataka, 560092, India.

Introduction: Dry eye is a multifactorial condition of the eye caused by insufficient tear production and imbalance in tear composition leading to faster evaporation of tear fluid. It is also associated with inflammation that often leads to ocular surface damage. Symptoms of dry eyes include itchiness, soreness, red eyes, a burning sensation, eye fatigue and blurred vision. Read More

View Article and Full-Text PDF

Surgical success of lateral rectus resection for residual and recurrent esotropia.

Int Ophthalmol 2021 Jun 15. Epub 2021 Jun 15.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: To assess the surgical outcomes of reoperations for residual and recurrent esotropia.

Methods: A retrospective chart review of all patients who underwent surgery during 2000-2017 at a tertiary referral medical center for recurrent or residual esotropia was conducted. Patients who underwent bilateral medial rectus recession as primary surgery and lateral rectus resection as second surgery were included. Read More

View Article and Full-Text PDF

Complications and visual outcomes of cataract surgery in patients with pseudoexfoliation.

Int Ophthalmol 2021 Jun 15. Epub 2021 Jun 15.

Cataract & Refractive Surgery Services, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To compare outcomes of cataract surgery performed by ophthalmic trainees and consultants in patients associated with pseudoexfoliation (PXF) METHODS: Retrospective review of medical records of all patients with PXF who had undergone cataract surgery from January 2016 to December 2018 at L V Prasad Eye Institute, Hyderabad, India, were analysed RESULTS: A total of 914 eyes were included in the study; surgeries on 501 (54.8%) eyes with PXF were performed by trainees, while 413 (45.2%) were performed by consultants. Read More

View Article and Full-Text PDF

Differential Effect of Proinflammatory Cytokines on Corneal and Conjunctival Epithelial Cell Mucins and Glycocalyx.

Transl Vis Sci Technol 2021 Jun;10(7):17

Chapman University School of Pharmacy, Chapman University, Irvine, CA, USA.

Purpose: Ocular surface mucins and glycocalyx are critical for providing ocular hydration as well lubrication and repelling pathogens or allergens. Elevated levels of tear proinflammatory cytokines in dry eye may have detrimental effect on mucins and glycocalyx. The present study tested the effect of proinflammatory cytokines IL-6, TNF-α, and IFN-γ on membrane-tethered mucins expression, glycocalyx, and viability of ocular surface epithelial cells. Read More

View Article and Full-Text PDF

Evaluation of Long-Lasting Potential of Suprachoroidal Axitinib Suspension Via Ocular and Systemic Disposition in Rabbits.

Transl Vis Sci Technol 2021 Jun;10(7):19

Clearside Biomedical Inc., Alpharetta, GA, USA.

Purpose: Axitinib, a tyrosine kinase inhibitor, is a potent inhibitor of vascular endothelial growth factor (VEGF) receptors -1, -2 and -3. Suprachoroidal (SC) delivery of axitinib, combined with pan-VEGF inhibition activity of axitinib, has the potential to provide additional benefits compared to the current standard of care with intravitreal anti-VEGF-A agents. This study evaluated the ocular pharmacokinetics and systemic disposition of axitinib after SC administration in rabbits. Read More

View Article and Full-Text PDF

The prevalence and break down of narrow anterior chamber angle pathology presenting to a general ophthalmology clinic.

Medicine (Baltimore) 2021 Jun;100(24):e26195

East Kent Hospitals University NHS Foundations Trust, New Hayesbank NHS Eye Clinic, United Kingdom.

Abstract: To approximate the breakdown of narrow anterior chamber angle conditions, on general ophthalmology clinics, in the predominantly white population of the South East Kent region in the United Kingdom.A review was done of all patients attending a secondary care ophthalmology general clinic over a 3-year period. Patients were assessed with: slitlamp biomicroscopy with indentation gonioscopy; SD optical coherence tomography, Humphrey visual field analyzer, and high frequency ultrasound and categorized into various narrow angle conditions. Read More

View Article and Full-Text PDF

Digital reminiscence app co-created by people living with dementia and carers: Usability and eye gaze analysis.

Health Expect 2021 Jun 15. Epub 2021 Jun 15.

Ulster University, Newtownabbey, UK.

Background: This research reports on a pilot study that examined the usability of a reminiscence app called 'InspireD' using eye tracking technology. The InspireD app is a bespoke digital intervention aimed at supporting personalized reminiscence for people living with dementia and their carers. The app was developed and refined in two co-creation workshops and subsequently tested in a third workshop using eye tracking technology. Read More

View Article and Full-Text PDF

Association Between Problem Gambling and Functional Disability: A Nationally Representative Study Conducted in the United Kingdom.

J Addict Med 2021 Jun 14. Epub 2021 Jun 14.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain (LJ, AK, JMH); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain (LJ); Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux 78180, France (LJ); Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, United Kingdom (GFL-S, SP); University of Southern California, Suzanne Dworak Peck School of Social Work, 1149 South Hill Street Suite 1422, Los Angeles, CA, 90015 (HO); Philipps University of Marburg, Marburg, Germany (KK); ICREA, Pg. Lluis Companys 23, Barcelona, Spain (AK); Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea (JIS); The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom (LS).

Objectives: Problem gambling is associated with multiple detrimental health outcomes. However, to date, no study has investigated the association between problem gambling and functional disability. Therefore, the aim of this study was to investigate the association between problem gambling and functional disability in a UK nationally representative sample. Read More

View Article and Full-Text PDF

Use of Soft Contact Lens for Esthetic and Functional Rehabilitation.

Eye Contact Lens 2021 07;47(7):383-387

Eye Department of Contat lenses (P.P.Y. and V.F.S.), Hospital Sadalla Amin Ghanem, Joinville, SC, Brazil; Department of Ophthalmology (S.A.S.), Medical School, State University of Sao Paulo-UNESP, Botucatu, SP, Brazil; and Department of Biostatistic (C.R.P.), Biosciences Institute, State University of Sao Paulo-UNESP, Botucatu, SP, Brazil.

Objective: To report the outcomes and complications of colored soft contact lenses (SCLs) to improve esthetic or eye function in visually impaired (VI) or blind patients.

Methods: This retrospective study enrolled consecutive patients with unilateral or bilateral VI or blindness who had received colored SCLs to improve appearance or ocular function. Data were collected on demographics, complaints, complete ophthalmological examinations, types of SCL, follow-ups, and complications. Read More

View Article and Full-Text PDF

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

J Clin Invest 2021 Jun;131(12)

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes that promote retinal neovascularization (NV) to the transcription factors that regulate their expression. We demonstrated increased expression of HIF-1α and HIF-2α in the ischemic inner retina of PSR eyes. Read More

View Article and Full-Text PDF

The AAV9 variant capsid AAV-F mediates widespread transgene expression in non-human primate spinal cord after intrathecal administration.

Hum Gene Ther 2021 Jun 15. Epub 2021 Jun 15.

Massachusetts General Hospital, 2348, Boston, Massachusetts, United States;

Intrathecal delivery of AAV9 into the subarachnoid space has been shown to transduce spinal cord and brain and be less affected by pre-existing antibodies, which are lower in cerebral spinal fluid (CSF). Still, efficiency of transduction needs to be improved. Recently we identified a new capsid from a library selection in mice, called AAV-F, that allowed robust transduction of the spinal cord gray matter after lumbar injection. Read More

View Article and Full-Text PDF

Human Induced pluripotent stem cells-derived corneal endothelial-like cells promote corneal transparency in a rabbit model of bullous keratopathy.

Stem Cells Dev 2021 Jun 15. Epub 2021 Jun 15.

First Affiliated Hospital of Harbin Medical University, 74559, Harbin, Heilongjiang, China;

The corneal endothelium(CE) is vital for the cornea to maintain its transparency. However, CE dysfunction occurs due to aging, intraocular surgery, trauma, dystrophy, etc. Corneal transplantation is the only method to clinically treat CE dysfunction; however, this treatment strategy faces the disadvantages of a global cornea shortage, graft failure, and severe side effects. Read More

View Article and Full-Text PDF

Experimental-based validation of corneal lenticule banking in a health authority-licensed facility.

Tissue Eng Part A 2021 Jun 15. Epub 2021 Jun 15.

Singapore National Eye Centre, Cornea External Disease and Refractive, 11 Third Hospital Avenue, Level 8, Singapore, Singapore, 168751.

With the expected rise in patients undergoing refractive lenticule extraction worldwide, the amount of discarded corneal stromal lenticules will increase. Therefore, establishing a lenticule bank to collect, catalog, process, cryopreserve and distribute the lenticules (for future therapeutic needs) could be advantageous. Here, we validated the safety of lenticule banking, which involved the collection of human lenticules from our eye clinic, transportation of the lenticules to a Singapore Ministry of Health-licensed lenticule bank, processing and cryopreservation of the lenticules, which after 3 months or, a longer-term, 12 months, were retrieved and transported to our laboratory for implantation in rabbit corneas. Read More

View Article and Full-Text PDF

Clinically applicable artificial intelligence algorithm for the diagnosis, evaluation, and monitoring of acute retinal necrosis.

J Zhejiang Univ Sci B 2021 Jun;22(6):504-511

Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

The prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis (ARN). The potential application of artificial intelligence (AI) algorithms in these areas of clinical research has not been reported previously. The present study aims to create a computational algorithm for the automated detection and evaluation of retinal necrosis from retinal fundus photographs. Read More

View Article and Full-Text PDF