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Phylogenetic analysis and expression differences of eye-related genes in cavefish genus Sinocyclocheilus.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Membrane Biology, Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

The adaptive evolution of visual systems has been observed in many cavefish. However, little is known about the molecular mechanisms underlying these adaptations, which include regressive changes such as eye degeneration. Here, we analyzed phylogenetic and expression patterns of six eye-related genes (crx, foxg1b, opn1sw2, otx2, rho, and sox2) in twelve Sinocyclocheilus species from China including eight stygobionts and four stygophiles, and examined photoreceptor cell morphology of these species. Read More

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http://dx.doi.org/10.1111/1749-4877.12466DOI Listing

Functionally Distinct IFNγ IL-17A Th cells in experimental autoimmune uveitis: T cell heterogeneity, migration and steroid response.

Eur J Immunol 2020 Jul 11. Epub 2020 Jul 11.

UCL Institute of Ophthalmology, University College London, London, UK.

Immunopathogenic roles for both Th1 (CD4 IFNγ ) and Th17 (CD4 IL-17A ) cells have been demonstrated in experimental autoimmune uveitis (EAU). However, the role for Th17/Th1 (CD4 T cells co-expressing IFNγ and IL-17A) cells in EAU is not yet understood. Using interphotoreceptor retinoid-binding protein (IRBP) peptide-induced EAU in mice, we found increased levels of Th17/Th1 cells in EAU retinae (mean 9. Read More

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http://dx.doi.org/10.1002/eji.202048616DOI Listing

Spontaneously occurring melanoma in animals and their relevance to human melanoma.

J Pathol 2020 Jul 11. Epub 2020 Jul 11.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

In contrast to other cancer types, melanoma incidence has been increasing over the last 50 years, and while it still represents less than 5% of all cutaneous malignancies, melanoma accounts for the majority of skin cancer deaths, due to its propensity to metastasise. Whilst melanoma most commonly affects the skin, it can also arise in mucosal surfaces, the eye and the brain. For new therapies to be developed, a better understanding of the genetic landscape, signalling pathways and tumour-microenvironmental interactions are needed. Read More

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http://dx.doi.org/10.1002/path.5505DOI Listing

Cost-effectiveness of routine calcitonin screening and fine-needle aspiration biopsy in preoperative diagnosis of medullary thyroid Cancer in the United States.

Oral Oncol 2020 Jul 8;110:104878. Epub 2020 Jul 8.

Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA; Division of Thyroid and Parathyroid Endocrine Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Objectives: examine the cost-effectiveness of routine Calcitonin (Ctn) screening test in the United States.

Materials And Methods: Markov chain model was developed that compares fine-needle aspiration biopsy (FNAB) with Ctn screening vs. FNAB-only in the evaluation of a thyroid nodule with non-highly suspicious findings. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104878DOI Listing

Computer-aided classification of suspicious pigmented lesions using wide-field images.

Comput Methods Programs Biomed 2020 Jul 1;195:105631. Epub 2020 Jul 1.

Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA; MIT linQ, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA; Brigham and Women's Hospital - Harvard Medical School, 75 Francis St, Boston, MA 02115, United States.

Background And Objective: Early identification of melanoma is conducted through whole-body visual examinations to detect suspicious pigmented lesions, a situation that fluctuates in accuracy depending on the experience and time of the examiner. Computer-aided diagnosis tools for skin lesions are typically trained using pre-selected single-lesion images, taken under controlled conditions, which limits their use in wide-field scenes. Here, we propose a computer-aided classifier system with such input conditions to aid in the rapid identification of suspicious pigmented lesions at the primary care level. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105631DOI Listing

Real time comprehension of Spanish articles in children with developmental language disorder: Empirical evidence from eye movements.

J Commun Disord 2020 Jul 3;87:106027. Epub 2020 Jul 3.

Faculty of Psychology, Universitat de Barcelona, Spain.

Function words and, more specifically, articles have been widely indicated as one of the main sources of difficulty for children with Developmental Language Disorder (DLD). The present study is the first to assess the online comprehension of Spanish articles in bilingual children with DLD. In an eye tracking experiment, we monitored participants' eye movements as they listened to Spanish articles embedded in structurally simple sentences. Read More

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http://dx.doi.org/10.1016/j.jcomdis.2020.106027DOI Listing

Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis.

EBioMedicine 2020 Jul 8;57:102878. Epub 2020 Jul 8.

School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; The State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China. Electronic address:

Background: Myopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect the biological processes affecting myopia progression.

Methods: Human Genetic Analyses: (1) gene set analysis (GSA) of new genome wide association study (GWAS) data for 593 individuals with high myopia (refraction ≤ -6 diopters [D]); (2) over-representation analysis (ORA) of 196 genes with de novo mutations, identified by whole genome sequencing of 45 high-myopia trio families, and (3) ORA of 284 previously reported myopia risk genes. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102878DOI Listing

Biomimetic Corneal Stroma Using Electro-Compacted Collagen.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Fairy Meadow, New South Wales, 2519, Australia. Electronic address:

Engineering substantia propria (or stroma of cornea) that mimics the function and anatomy of natural tissue is vital for in vitro modelling and in vivo regeneration. There are, however, few examples of bioengineered biomimetic corneal stroma. Here we describe the construction of an orthogonally oriented 3D corneal stroma model (3D-CSM) using pure electro-compacted collagen (EC). Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.004DOI Listing

A full-field 3D Digital Image Correlation and Modelling Technique to Characterise Anterior Cruciate Ligament Mechanics ex vivo.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

School of Engineering, University of Liverpool, Liverpool, L69 3GH, UK; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, UK.

It is limiting to use conventional methods when characterising material properties of complex biological tissues with inhomogeneous and anisotropic structure, such as the anterior cruciate ligament (ACL) in the knee joint. This study aims to develop and utilise a three-dimensional digital image correlation method (3D DIC) for the purpose of determining material properties of femur-ACL-tibia complex across the surface without any contact between the tissue and the loading equipment. A full-field (360° view) 3D DIC test setup consisting of six digital single-lens reflex cameras was developed and ACL specimens from skeletally mature dog knee joints were tested. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.003DOI Listing

Changes in intraocular pressure and angle structure after dilation in primary angle closure suspects with visually significant cataract.

Ophthalmology 2020 Jul 8. Epub 2020 Jul 8.

Department of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address:

Purpose: To evaluate the safety of pupillary dilation in primary angle closure suspects (PACS) with concurrent visually significant cataract (VSC), to identify risk factors associated with elevated IOP, and to describe changes in anterior segment anatomy following pupillary dilation.

Design: Prospective study.

Participants: Patients with PACS and VSC and no prior laser or intraocular surgery were recruited. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.07.009DOI Listing

Influence of Distance and Near Visual Impairment on Self-reported Near Visual Functioning in a Multi-country Study.

Ophthalmology 2020 Jul 8. Epub 2020 Jul 8.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: To assess the influence of distance and near visual impairment on self-reported near visual functioning (VF) among adults in a multi-country study.

Design: Population-based cross-sectional study.

Participants: Participants aged ≥35 years were randomly selected with cluster sampling at seven sites: rural sites in Nepal (Kaski) and India (Madurai), a semi-rural site in China (Shunyi), semi-urban sites in South Africa (Durban) and Niger (Dosso), and urban sites in the United States (Los Angeles) and China (Guangzhou). Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.07.006DOI Listing

Epidemiology of asteroid hyalosis and associations: the Gutenberg Health Study.

Ophthalmology 2020 Jul 8. Epub 2020 Jul 8.

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Department of Ophthalmology, Centre for Public Health, Institute of Clinical Sciences, School of Medicine, Queen's University Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.1016/j.ophtha.2020.07.008DOI Listing

Trans, trans-2,4-decadienal (tt-DDE), a composition of cooking oil fumes, induces oxidative stress and endoplasmic reticulum stress in human corneal epithelial cells.

Toxicol In Vitro 2020 Jul 8:104933. Epub 2020 Jul 8.

Eye Center of the 2(nd) Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang Province, China. Electronic address:

Indoor pollution with cooking oil fumes (COF) as one of the main components is closely related to ocular surface disorders. However, as the most abundant aldehyde in COF, the toxicity of trans, trans-2,4-decadienal (tt-DDE) on human cornea has not been explored before. In the present study, we observed a time- and dose-dependent cytotoxicity induced by tt-DDE in human corneal epithelial (HCE) cells, as evidenced by decreased cell viability, altered cell morphology, and increased proportion of apoptotic cells. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104933DOI Listing

National survey of Canadian Retina Society members on guidelines for ophthalmic care during the COVID-19 crisis: Canadian Retina Research Network (CR2N) COVID-19 Steering Committee analysis.

Can J Ophthalmol 2020 Jul 8. Epub 2020 Jul 8.

Department of Ophthalmology, Université de Montréal, Montreal, Que; Markham Stouffville Hospital, Markham, Ont; Sunnybrook Health Sciences Centre, Toronto, Ont.

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http://dx.doi.org/10.1016/j.jcjo.2020.06.001DOI Listing

rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding.

Aging (Albany NY) 2020 Jul 10;12. Epub 2020 Jul 10.

Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

In this study, we investigated the mechanisms underlying the altered hepatic glucose metabolism and enhanced diabetes risk in individuals with the rs290487 C allele. Analysis of 195 cirrhotic patients revealed a higher insulin resistance index and incidence of hepatogenous diabetes in patients with the rs290487 C/C genotype compared to those with the C/T or T/T genotype. The experiments using targeted mutant PLC-PRF-5 cell line showed that cells with the rs290487 C/C genotype (C/C cells) had higher glucose production, lower glucose uptake, and lower mRNA and protein levels than those with the C/T genotype (C/T cells). Read More

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http://dx.doi.org/10.18632/aging.103442DOI Listing

Individual differences in working memory capacity and the regulation of arousal.

Atten Percept Psychophys 2020 Jul 10. Epub 2020 Jul 10.

Department of Psychology, Arizona State University, 950 S. McAllister Ave., Tempe, AZ, 85287, USA.

Previously it has been theorized that differential functioning of the locus coeruleus-norepinephrine (LC-NE) system affects people's ability to regulate arousal, which has impacts on cognitive abilities. In the present study, we investigated three potential mechanisms by which the LC-NE system can fail to regulate arousal appropriately: hypoarousal, hyperarousal, and dysregulation of arousal. Each of these three could potentially account for why arousal affects cognition. Read More

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http://dx.doi.org/10.3758/s13414-020-02077-0DOI Listing

Strategic Spatial Anchoring as Cognitive Compensation During Word Categorization in Parkinson's Disease: Evidence from Eye Movements.

J Psycholinguist Res 2020 Jul 10. Epub 2020 Jul 10.

Department of Spanish, University of Concepción, Concepción, Chile.

The association between a word and typical location (e.g., cloud-up) appears to modulate healthy individuals' response times and visual attention. Read More

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http://dx.doi.org/10.1007/s10936-020-09718-3DOI Listing

Correction: Efficacy of selective laser trabeculoplasty in primary angle closure disease.

Eye (Lond) 2020 Jul 10. Epub 2020 Jul 10.

Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41433-020-1047-1DOI Listing

Transforming ophthalmic education into virtual learning during COVID-19 pandemic: a global perspective.

Eye (Lond) 2020 Jul 10. Epub 2020 Jul 10.

Division of Ophthalmology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Objective: The coronavirus disease 2019 (COVID-19) pandemic has imposed measures of social distancing and barriers in delivery of "in person" education. Institutions, involved in training the next generation of ophthalmologists, are using alternative teaching methods to maintain the standard of education.

Methods: We conducted a worldwide survey among physicians, who are actively involved in Ophthalmology-related education, between 3 and 14 April 2020. Read More

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http://dx.doi.org/10.1038/s41433-020-1080-0DOI Listing

Lagophthalmos after congenital ptosis surgery: comparison between maximal levator resection and frontalis sling operation.

Eye (Lond) 2020 Jul 10. Epub 2020 Jul 10.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background/objectives: To compare postoperative lagophthalmos after maximal levator resection (MLR) and frontalis suspension (FS) in congenital ptosis patients with poor levator function (LF).

Methods: A cross-sectional study was performed to compare postoperative outcomes in patients with preoperative LF ≤ 4 mm who had undergone MLR or FS at a single tertiary institution, and who had visited the outpatient clinic between February 2017 and August 2018. Main outcome measures were as follows: (1) Preoperative LF and margin reflex distance 1 (MRD1), (2) Postoperative MRD1, lagophthalmos and grade of superficial punctate keratopathy (SPK). Read More

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http://dx.doi.org/10.1038/s41433-020-1081-zDOI Listing

Clinical manifestations of cuticular drusen in Korean patients.

Sci Rep 2020 Jul 10;10(1):11469. Epub 2020 Jul 10.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows ethnic differences. We investigated clinical manifestations of cuticular drusen in Korean patients to evaluate possible ethnic differences. Read More

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http://dx.doi.org/10.1038/s41598-020-68493-2DOI Listing

The Impact of Strategic White Matter Hyperintensity Lesion Location on Language.

Am J Geriatr Psychiatry 2020 Jun 17. Epub 2020 Jun 17.

Memory Aging and Cognition Center, National University Health System (SH, EC, CC), Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore (SH, CC), Singapore.

Objective: The impact of white matter hyperintensities (WMH) on language possibly depends on lesion location through disturbance of strategic white matter tracts. We examined the impact of WMH location on language in elderly Asians.

Design: Cross-sectional. Read More

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http://dx.doi.org/10.1016/j.jagp.2020.06.009DOI Listing

Tattoo Pigment within Regional Lymph Nodes Mimicking Cutaneous Melanoma Metastasis.

Acta Dermatovenerol Croat 2020 Jul;28(1):47-48

Nikolina Jurišić, MD,

Dear Editor, The diagnosis of malignant melanoma accounts for 1-2% of all cancer diagnoses, around 4% of all malignant skin diseases, and 80% of all skin cancer deaths (1). The prognosis depends on several factors including tumor size, Clark level, Breslow thickness, location, ulceration, and presence of metastases. Detection of lymph node metastasis is initially accomplished by clinical examination and by operative evaluation for occult metastasis using sentinel lymph node biopsy (SLNB) when indicated (2). Read More

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Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report.

Acta Dermatovenerol Croat 2020 Jul;28(1):29-33

Natália Rybárová, MD, Oční klinika FN Brno, Jihlavská 20, 625 00 Brno, Czech Republic;

We report a case of lamellar ichthyosis and sight-threatening complications of cicatricial ectropion in an adult male patient which was surgically managed with tectonic penetrating keratoplasty. We present a case of autosomal-recessive lamellar ichthyosis in a 47-year-old man who was referred to our outpatient eye clinic for treatment of primary keratouveitis of the right eye with keratolysis and exudation in the anterior chamber. A diagnosis of cicatricial ectropion with serious lagophthalmos was established on examination. Read More

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Discrepancies between explicit and implicit evaluation of aesthetic perception ability in individuals with autism: a potential way to improve social functioning.

BMC Psychol 2020 Jul 10;8(1):74. Epub 2020 Jul 10.

Department of Psychology, University Cattolica del Sacro Cuore, Milan, Italy.

Background: The capacity to evaluate beauty plays a crucial role in social behaviour and social relationships. It is known that some characteristics of beauty are important social cues that can induce stereotypes or promote different behavioural expectations. Another crucial capacity for success in social interactions is empathy, i. Read More

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http://dx.doi.org/10.1186/s40359-020-00437-xDOI Listing

Geographic availability to optometry services across Canada: mapping distribution, need and self-reported use.

BMC Health Serv Res 2020 Jul 10;20(1):639. Epub 2020 Jul 10.

School of Rehabilitation Science and Canadian Centre for Health and Safety in Agriculture (CCHSA), University of Saskatchewan, Rm 1340 - E wing - Health Sciences Building, 104 Clinic Place PO Box 23, Saskatoon, Saskatchewan, S7N 2Z4, Canada.

Background: This research investigates the distribution of optometrists in Canada relative to population health needs and self-reported use of vision services.

Methods: Optometrist locations were gathered from provincial regulatory bodies. Optometrist-to-population ratios (i. Read More

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http://dx.doi.org/10.1186/s12913-020-05499-6DOI Listing

The protective effect of 3% diquafosol on meibomian gland morphology in glaucoma patients treated with prostaglandin analogs: a 12-month follow-up study.

BMC Ophthalmol 2020 Jul 10;20(1):277. Epub 2020 Jul 10.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-Gu, Gwangju, 61469, South Korea.

Background: To determine if 3% diquafosol (DQS) can preserve the meibomian gland morphology in glaucoma patients treated with prostaglandin analogs (PGA) for a 12-month follow-up period.

Methods: This study included 84 eyes of 46 normal tension glaucoma (NTG) patients who were treated with either preservative-containing PGA (PC-PGA; 16 patients, 28 eyes), preservative-free PGA (PF-PGA; 21 patients, 39 eyes), or a combination of PC-PGA and 3% DQS (PC-PGA + DQS; 9 patients, 17 eyes). The meibography of the upper eyelid was acquired using Keratograph® 5 M at baseline and at each follow-up (1, 3, 6, 9, and 12 months). Read More

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http://dx.doi.org/10.1186/s12886-020-01550-6DOI Listing

COVID-19 pandemic and psychological fatigue in Turkey.

Int J Soc Psychiatry 2020 Jul 10:20764020941889. Epub 2020 Jul 10.

Department of Psychology, School of Humanities and Society Sciences, Ibn Haldun University, Istanbul, Turkey.

Aim: The aim of this study was to investigate the association between the COVID-19 pandemic and psychological fatigue as a mental health issue among the population of Istanbul, Turkey.

Participants And Methods: This is a cross-sectional study conducted in Istanbul, Turkey, between March and June 2020, where a total of 4,700 persons were approached and 3,672 (78%) of participants (64.4% males and 35. Read More

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http://dx.doi.org/10.1177/0020764020941889DOI Listing

Sjögren's Syndrome Minor Salivary Gland CD4 Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile.

J Clin Med 2020 Jul 8;9(7). Epub 2020 Jul 8.

Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology Program, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

To assess the types of salivary gland (SG) T cells contributing to Sjögren's syndrome (SS), we evaluated SG T cell subtypes for association with disease features and compared the SG CD4 memory T cell transcriptomes of subjects with either primary SS (pSS) or non-SS sicca (nSS). SG biopsies were evaluated for proportions and absolute numbers of CD4 and CD8 T cells. SG memory CD4 T cells were evaluated for gene expression by microarray. Read More

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http://dx.doi.org/10.3390/jcm9072164DOI Listing

A Novel Vitamin E TPGS-Based Formulation Enhances Chlorhexidine Bioavailability in Corneal Layers.

Pharmaceutics 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Medicine and Health Science, "V. Tiberio" University of Molise, 86100 Campobasso, Italy.

Keratitis is a severe condition characterized by inflammation of the cornea following a local trauma. The most common ocular disease is the bacterial one, which requires an antibiotic treatment. The major limitation of this therapy is the resistance of the antibiotic. Read More

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http://dx.doi.org/10.3390/pharmaceutics12070642DOI Listing

A dual thiourea-appended perylenebisimide "turn-on" fluorescent chemosensor with high selectivity and sensitivity for Hg in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118678. Epub 2020 Jul 2.

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Sensing heavy metal ions particularly for the most toxic Hg is a long-term pursuit for chemists because of its obvious and extreme harmfulness to both the environment and human health. Herein, a novel 'turn-on' perylenebisimide-thiourea fluorescent probe PBI-BTB is achieved for rapid detection of Hg in a DMSO/HO (5/1, v/v) solution through a typical Hg-promoting desulfurization reaction, which has been investigated through Job's plot titration, FT-IR, H NMR and HRMS analysis. A remarkable fluorescence emission enhancement at 540 and 580 nm is observed in the presence of Hg, which is visible to the naked eye with high selectivity and sensitivity. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118678DOI Listing

A colorimetric chemosensor for pyrophosphate based on mono-pyrenylurea in aqueous media.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118658. Epub 2020 Jul 3.

College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, Heilongjiang 161006, PR China. Electronic address:

Research on pyrophosphate ions detection remains important because it plays crucial roles in various fields. A simple and new colorimetric sensor for pyrophosphate (PPi) based on mono-pyrenylurea ligand (L) has been designed and synthesized by a simple reaction of 1-pyrenemethylamine hydrochloride with p-nitrophenylisocyanate. In DMSO-15% HO solution and DMSO-15% HEPES (10 mM, pH = 7. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118658DOI Listing

Vision impairment and cognitive function among urban-dwelling malaysians aged 55 years and over from the Malaysian Elders Longitudinal Research (MELoR) study.

Arch Gerontol Geriatr 2020 Jun 26;90:104165. Epub 2020 Jun 26.

Department of Ophthalmology, University Malaya Medical Centre, Kuala Lumpur, Malaysia; University of Malaya Eye Research Centre (UMERC), Department of Ophthalmology, University of Malaya, Malaysia. Electronic address:

Introduction: Published literature on vision impairment and cognitive function amongst older Malaysians remains scarce. This study investigates the association between vision impairment and cognitive function in an older Malaysian population.

Methods: Subjects aged 55 years and above from the Malaysian Elders Longitudinal Research (MELoR) study with available information on vision and Montreal Cognitive Assessment (MoCA) scores were included. Read More

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http://dx.doi.org/10.1016/j.archger.2020.104165DOI Listing

Predicted aggregation-prone region (APR) in βB1-crystallin forms the amyloid-like structure and induces aggregation of soluble proteins isolated from human cataractous eye lens.

Int J Biol Macromol 2020 Jul 7. Epub 2020 Jul 7.

Department of Biotechnology, Central University of Rajasthan, NH-8 Bandersindri, Kishangarh, Ajmer 305817, Rajasthan, India. Electronic address:

The aggregation of β-crystallins in the human eye lens constitutes a critical step during the development of cataract. We anticipated that the presence of Aggregation-prone Regions (APRs) in their primary structure, which might be responsible for conformational change required for the self-assembly. To examine the presence of APRs, we systematically analyzed the primary structures of β-crystallins. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.028DOI Listing

Identification of Loss-of-Function HOXA2 Mutations in Chinese Families with Dominant Bilateral Microtia.

Gene 2020 Jul 7:144945. Epub 2020 Jul 7.

Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address:

HOX genes are important regulatory genes patterning head formation, including development of the ear. Microtia is a congenital ear anomaly characterized by lacking all or part of the structures of the outer ear. To date, only four HOXA2 mutations were reported in families with autosomal-recessive or dominant microtia, with or without hearing impairment. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144945DOI Listing

Metabolic signature of eyelid basal cell carcinoma.

Exp Eye Res 2020 Jul 7:108140. Epub 2020 Jul 7.

Department of Ophthalmology, West Virginia University, Morgantown, WV, 26506, USA; Department of Biochemistry, West Virginia University, Morgantown, WV, 26506, USA. Electronic address:

Purpose: Eyelid basal cell carcinoma (BCC) is the most common eyelid malignancy. Metabolic reprogramming is critical in tumorigenesis, but the metabolic feature of eyelid BCC remains elusive. In this study, we aim to reveal the metabolic profile in eyelid BCC using targeted metabolomics. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108140DOI Listing

Welcome to the first Corneal Special Issue.

Authors:
Steven E Wilson

Exp Eye Res 2020 Jul 7:108143. Epub 2020 Jul 7.

The Cole Eye Institute; The Cleveland Clinic.

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http://dx.doi.org/10.1016/j.exer.2020.108143DOI Listing

SARS-CoV-2 infection in conjunctival tissue.

Lancet Respir Med 2020 Jul;8(7):e57

Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, 168751, Singapore; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(20)30272-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340386PMC

Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update.

Mol Ther 2020 Jun 30. Epub 2020 Jun 30.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC 3002, Australia. Electronic address:

Aberrant growth of blood vessels (neovascularization) is a key feature of severe eye diseases that can cause legal blindness, including neovascular age-related macular degeneration (nAMD) and diabetic retinopathy (DR). The development of anti-vascular endothelial growth factor (VEGF) agents has revolutionized the treatment of ocular neovascularization. Novel proangiogenic targets, such as angiopoietin and platelet-derived growth factor (PDGF), are under development for patients who respond poorly to anti-VEGF therapy and to reduce adverse effects from long-term VEGF inhibition. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.06.029DOI Listing

Ophthalmic Complications in Pediatric Uveitis.

Ocul Immunol Inflamm 2020 Jul 10:1-6. Epub 2020 Jul 10.

Advanced Pediatric Centre Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: We aim to look at the complications encountered by a cohort of pediatric uveitis patients from north India.

Methods: Retrospectively, complications seen in patients younger than 16 years diagnosed with uveitis between January 2006 to March 2015 were noted.

Results: Data of 104 children, with a mean follow-up of 3. Read More

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http://dx.doi.org/10.1080/09273948.2020.1762897DOI Listing

Endovascular Embolization of a Paracavernous Arteriovenous Fistula Through a Cortical Venous Access: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Jul 10. Epub 2020 Jul 10.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

We present the case of a 62-yr-old female with a right bulging eye and intermittent headaches. A T2 weighted magnetic resonance image revealed a dilated serpiginous vessel in the right orbit and abnormal flow voids lateral to the orbital apex. The right internal carotid contrast injection demonstrated a dural arteriovenous fistula (dAVF) fed by the ophthalmic artery and drainage into the ipsilateral superficial middle cerebral veins (SMCVs) and the basal vein of Rosenthal without opacification of the cavernous sinus. Read More

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http://dx.doi.org/10.1093/ons/opaa210DOI Listing

Importance of tear volume for positivity of tear matrix metalloproteinase-9 immunoassay.

PLoS One 2020 10;15(7):e0235408. Epub 2020 Jul 10.

Department of Ophthalmology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

The tear matrix metalloproteinase-9 (MMP-9) immunoassay (Inflammadry) exhibits variable results in dry eye (DE) patients. We investigated if the tear volume in DE patients affects the results of MMP-9 immunoassay in clinical and in vitro settings. This cross-sectional study enrolled 188 eyes of 188 DE patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235408PLOS

Potential roles of MNREAD acuity charts and contrast/glare sensitivity in Ranibizumab treatment of branch retinal vein occlusion.

PLoS One 2020 10;15(7):e0235897. Epub 2020 Jul 10.

Department of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

Background/objectives: To investigate the potential utility of MNREAD acuity charts and contrast/glare sensitivity (CGS) assessment for evaluating the efficacy of an initial treatment with ranibizumab (Lucentis®) for branch retinal vein occlusion (BRVO).

Methods: Intravitreal injections of ranibizumab were administered in 43 eyes of 43 treatment-naïve patients with BRVO. Efficacy was assessed 1 month later. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235897PLOS

Choroidal Neovascularization in Primary Membranous Nephropathy.

Am J Case Rep 2020 Jul 10;21:e923454. Epub 2020 Jul 10.

Department of Medicine - Ophthalmology, University of Udine, Udine, Italy.

BACKGROUND We describe the retinal findings in a patient affected by primary membranous nephropathy (MN). CASE REPORT A 61-year-old man presented with a 3-month history of metamorphopsia and decreased visual acuity in both eyes. He was affected by nephrotic syndrome in primary MN and treated with systemic corticosteroids. Read More

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http://dx.doi.org/10.12659/AJCR.923454DOI Listing

Positive relationship of hypertensive retinopathy with carotid intima--media thickness in hypertensive patients.

J Hypertens 2020 Jul 6. Epub 2020 Jul 6.

Department of Ophthalmology, Peking University First Hospital, Beijing.

Objectives: We aimed to explore the relationship of hypertensive retinopathy with carotid intima--media thickness (CIMT), and to examine the possible effect modifiers in Chinese adults with hypertension.

Methods: We conducted a cross-sectional study of 12 342 hypertensive patients with complete exit site visit data from the China Stroke Primary Prevention Trial. CIMT was measured by carotid ultrasonography. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002509DOI Listing

Reply Letter: "Neurotized Platysma Graft: A New Technique for Functional Reanimation of the Eye Sphincter in Long Standing Facial Paralysis".

Authors:
Tomaz Nassif

Plast Reconstr Surg 2020 Jul 6. Epub 2020 Jul 6.

1. Tomaz Nassif, MD. Department of Reconstructive Microsurgery, HSE, Rio de Janeiro, Brazil & Clínica de Cirurgia Plástica Rio de Janeiro, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1097/PRS.0000000000007211DOI Listing

Endoscopic Support and Virtual Surgical Planning as an Alternative to Repair Orbital Wall Fractures.

J Craniofac Surg 2020 Jul 1. Epub 2020 Jul 1.

Oral and Maxillofacial Surgery, Universidad El Bosque.

The reconstruction of the orbit has been carried out throughout history using different techniques. However, the persistence of high rates of complications mainly associated with the position of the eyeball and the migration of reconstruction implants have generated the need and importance of continuing to study new techniques, including with the help of technology. Virtual planning combined with endoscopic access and 3D models could decrease the number of complications associated with the aforementioned problems. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006736DOI Listing

Association Between Compensatory Overaction of the Non-Injured Eye, Measured by HESS Chart and Postoperative Diplopia in Blow-Out Fracture.

J Craniofac Surg 2020 Jul 3. Epub 2020 Jul 3.

Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

In orbital floor fracture, diplopia often persists post-operatively. This study evaluated the association between pre-operative parameters concerning the extent of the injury and post-operative diplopia, using multivariate analysis. A retrospective computed tomography analysis and chart review was performed for patients with punched out orbital floor fracture, who underwent operations during the period from April 2011 to March 2018. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006728DOI Listing

Delayed Ocular Motility Restriction After Endoscopic Sinus Surgery in a Patient With Chronic Rhinosinusitis and an Old Medial Orbital Wall Fracture.

J Craniofac Surg 2020 Jul 3. Epub 2020 Jul 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Maryknoll Hospital, Busan, Republic of Korea.

The orbital complications of endoscopic sinus surgery, including diplopia and ocular motility restriction, are mainly caused by direct injury to the orbital structures. These complications are rare, but can have catastrophic consequences. Symptoms occur immediately after surgery in most cases. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006718DOI Listing
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