595,104 results match your criteria Eye London England[Journal]


Altered sleep architecture, rapid eye movement (REM) sleep, and neural oscillation in a mouse model of human chromosome 16p11.2 microdeletion.

Sleep 2018 Dec 12. Epub 2018 Dec 12.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA.

Sleep abnormalities are common among children with neurodevelopmental disorders. The human chr16p11.2 microdeletion is associated with a range of neurological and neurobehavioral abnormalities. Read More

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December 2018
2 Reads

Stapes footplate defect as a source of CSF leak and otogenic meningitis in a patient with a cochlear implant.

Ear Nose Throat J 2018 Dec;97(12):E31-E32

Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

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December 2018

Eye blinks are perceived as communicative signals in human face-to-face interaction.

PLoS One 2018 12;13(12):e0208030. Epub 2018 Dec 12.

Language and Cognition Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.

In face-to-face communication, recurring intervals of mutual gaze allow listeners to provide speakers with visual feedback (e.g. nodding). Read More

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December 2018
3 Reads

Patient Reported Outcomes, Functional Assessment and Utility Values in Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Johns Hopkins Wilmer Eye Institute, Maryland USA.

In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Read More

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December 2018
1 Read

Effect of Mannitol on Intraocular Pressure in Vitrectomized and Non-vitrectomized Eyes: A Prospective Comparative Study.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma Services, Aravind Eye Hospital, Coimbatore, India.

Purpose: To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and non-vitrectomized eyes.

Methods: Prospective comparative case study. Eyes with IOP ≥40▒mm Hg were included. Read More

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December 2018

Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

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December 2018
2 Reads

Optic Nerve Head Drusen: The Relationship Between Intraocular Pressure and Optic Nerve Structure and Function: Comment.

Authors:
Bradley J Katz

J Neuroophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Departments of Ophthalmology and Visual Sciences, and Neurology, John A Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, Utah.

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December 2018

The transfer function of the rhesus macaque oculomotor system for small-amplitude slow motion trajectories.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Werner Reichardt Centre for Integrative Neuroscience, Germany.

Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well-studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular drifts, can be generated systematically. Read More

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December 2018

PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population.

DNA Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University , Wenzhou, Zhejiang, China .

Acute anterior uveitis (AAU) is an ordinary type of uveitis, which is an autoimmune disease produced by T cells. Programmed apoptosis protein 1 (PD-1) is a vital negative regulatory protein of immune tolerance. We detect the single nucleotide polymorphisms (SNPs) rs41386349, rs10204525, and rs2227982 of PD-1 to investigate the correlation between PD-1 polymorphisms and AAU. Read More

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December 2018

Longitudinal Chromatic Aberration and Polychromatic Image Quality Metrics of Intraocular Lenses.

J Refract Surg 2018 Dec;34(12):832-838

Purpose: To measure longitudinal chromatic aberration (LCA) of various intraocular lenses (IOLs) and to assess LCA effects on polychromatic image quality with a focus on multifocal IOL designs.

Methods: The LCA values of four multifocal IOL models (three diffractive models: AT LARA 829MP and AT LISA 809M [both from Carl Zeiss Meditec AG, Jena, Germany] and Restor SN6AD1 [Alcon Laboratories, Inc., Fort Worth, TX] and one refractive model [Mini Well Ready; SIFI Medtech, Sant'Antonio, Italy]) were compared with that of their monofocal counterparts. Read More

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December 2018

Safety and Efficacy of a New Phakic Posterior Chamber IOL for Correction of Myopia: 3 Years of Follow-up.

J Refract Surg 2018 Dec;34(12):817-823

Purpose: To evaluate the outcomes of a new posterior chamber phakic intraocular lens (IPCL; Care Group, Baroda, India) to correct myopia.

Methods: This prospective, observational case series included 30 eyes undergoing implantation of the IPCL for high myopia (> -8.00 diopters [D]). Read More

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December 2018

Suction Stability Management in SMILE: Development of a Decision Tree for Managing Eye Movements and Suction Loss.

J Refract Surg 2018 Dec;34(12):809-816

Purpose: To develop a comprehensive protocol for suction stability management during small incision lenticule extraction (SMILE).

Methods: This was a retrospective video review of all SMILE cases where suction loss occurred or eye movement was noted in the medical record. The different types of eye movement were collated. Read More

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December 2018

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

Elife 2018 Dec 12;7. Epub 2018 Dec 12.

Department of Neuroscience, The Scripps Research Institute, Jupiter, United States.

Signaling by the G protein Coupled Receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of Regulators of G protein Signaling (RGS) proteins that deactivate heterotrimeric G proteins. RGS proteins are elaborately regulated and comprise multiple domains and subunits, yet structural organization of these assemblies is poorly understood. Read More

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December 2018
1 Read

Efficacy and safety of pulsed intravenous methylprednisolone in early active thyroid eye disease.

Orbit 2018 Dec 12:1-8. Epub 2018 Dec 12.

a Division of Orbit & Oculofacial Surgery, Department of Ophthalmology , National University Hospital , Singapore , Singapore.

Introduction: The mainstay of therapy for active inflammatory phase of thyroid eye disease (TED) is immunosuppression. Patients in our centre with early active TED are treated with pulsed intravenous methylprednisolone (IVMP). Two different protocols are offered in our centre: High dose (1g/day for 3 days, monthly for 6 months), or EUGOGO protocol (500 mg weekly for six weeks, followed by 250 mg weekly for the next 6 weeks). Read More

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December 2018
1 Read

imaging of structural, metabolic and functional brain changes in glaucoma.

Neural Regen Res 2019 Mar;14(3):446-449

NYU Langone Eye Center, Department of Ophthalmology, NYU School of Medicine, NYU Langone Health; Department of Radiology, NYU School of Medicine, NYU Langone Health; Center for Neural Science, Faculty of Arts and Science, New York University, New York, NY, USA.

Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. Read More

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March 2019
1 Read

Basics on the use of acid-sensing ion channels' inhibitors as therapeutics.

Neural Regen Res 2019 Mar;14(3):395-398

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA.

Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke, inflammation, arthritis, cancer, and recently migraine. More interestingly, acid-sensing ion channels may explain the sex differences in pain between males and females. Read More

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March 2019
1 Read

Congenital blindness is protective for schizophrenia and other psychotic illness. A whole-population study.

Schizophr Res 2018 Dec 7;202:414-416. Epub 2018 Jul 7.

Centre for Clinical Research in Neuropsychiatry, Division of Psychiatry, Faculty of Health and Medical Sciences, University of Western Australia, Medical Research Foundation Building, Rear 50, Murray Street, Perth 6000, Australia.

Congenital/early blindness is reportedly protective against schizophrenia. Using a whole-population cohort of 467,945 children born in Western Australia between 1980 and 2001, we examined prevalence of schizophrenia and psychotic illness in individuals with congenital/early blindness. Overall, 1870 children developed schizophrenia (0. Read More

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December 2018

Using intracameral vital dye as a guide for venting incision in acute corneal hydrops.

Eur J Ophthalmol 2018 Dec 12:1120672118818012. Epub 2018 Dec 12.

Ocular Trauma and Emergency Department and Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose:: To introduce a new surgical technique for the localization of corneal bulla to drain a massive corneal hydrops.

Methods:: Four consecutive cases with acute large protruded hydrops were selected. A limbal paracentesis was made via 15° blade. Read More

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December 2018
1 Read

Sequence effect in the treatment of proliferative diabetic retinopathy with intravitreal ranibizumab and panretinal photocoagulation.

Eur J Ophthalmol 2018 Dec 12:1120672118812270. Epub 2018 Dec 12.

In-Patient Department 2, Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China.

Purpose:: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy.

Methods:: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group). Each subject received three intravitreal ranibizumabs that were interleaved with three panretinal photocoagulations. Read More

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December 2018

Determination of Autoantibodies to Salivary Gland Antigens.

Methods Mol Biol 2019 ;1901:103-112

UCLA School of Dentistry, Los Angeles, CA, USA.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease marked by dry mouth/dry eye symptoms as a result of the destruction of the salivary and lacrimal glands. Patients with pSS may be at risk for the development of mucosa-associated lymphoid tissue (MALT) lymphoma. Testing of autoantibodies in the oral fluid of patients with pSS or MALT lymphoma using immunoassays may lead to a simple and noninvasive clinical tool for diagnostic or prognostic applications. Read More

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January 2019

Interleukin-22 promotes tumor angiogenesis.

Angiogenesis 2018 Dec 11. Epub 2018 Dec 11.

Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA.

T17 cells play important yet complex roles in cancer development and progression. We previously reported that T17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by T17 cells, directly acts on endothelial cells to promote tumor angiogenesis. Read More

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December 2018

Blindness and eye disease in a Tibetan region of China: findings from a Rapid Assessment of Avoidable Blindness survey.

BMJ Open Ophthalmol 2018 17;3(1):e000209. Epub 2018 Nov 17.

British Columbia Center for Epidemiology & International Ophthalmology and Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.

Introduction: The only population-based survey of blindness and visual impairment of a Tibetan population was conducted in the Tibet Autonomous Region in 1999.

Methods And Analysis: The Rapid Assessment of Avoidable Blindness methodology was used to conduct a survey of Kandze Tibetan Autonomous Prefecture, Sichuan Province of China in the Fall 2017. Using the 2010 census, 100 clusters of 50 participants aged 50 years or older were randomly sampled using probability proportionate to size. Read More

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November 2018

Ophthalmic phenotype of TCIRG1 gene mutations in Chinese infantile malignant osteopetrosis.

BMJ Open Ophthalmol 2018 17;3(1):e000180. Epub 2018 Nov 17.

Department of Ophthalmology, Beijing Children's Hospital, National Center for Children's Health, National Key Discipline of Pediatrics, Capital Medical University, Beijing, China.

Objective: To evaluate the ophthalmic phenotypes associated with T-cell immune regulator 1 (TCIRG1) mutations in Chinese patients with infantile malignant osteopetrosis (IMO).

Methods And Analysis: 27 Chinese TCIRG1-related osteoporosis infants were enrolled using direct DNA sequencing of PCR-amplified exons. 12 cases had frameshift mutation (the frameshift mutation group, group F), and 15 cases had point mutation (the point mutation group, group P). Read More

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November 2018
2 Reads

Intraocular lens dislocation: a novel in-situ scleral refixation technique using a 25 Gauge trocar in the anterior chamber.

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

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November 2018
1 Read

Sensitive Colorimetric Hg Detection via Amalgamation-Mediated Shape Transition of Gold Nanostars.

Front Chem 2018 27;6:566. Epub 2018 Nov 27.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China.

Reliable and sensitive methods to monitor mercury levels in real samples are highly important for environment protection and human health. Herein, a label-free colorimetric sensor for Hg quantitation using gold nanostar (GNS) has been demonstrated, based on the formation of Au-Hg amalgamate that leads to shape-evolution of the GNS and changes in its absorbance. Addition of ascorbic acid (AA) to GNS solution is important for quantitation of Hg, mainly because it can reduce Hg to Hg to enhance amalgamation on the GNSs and stabilize GNSs. Read More

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November 2018

Factors Affecting the Outcome of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment.

J Ophthalmol 2018 13;2018:9016302. Epub 2018 Nov 13.

MD Ophthalmology Resident, Bharatpur Eye Hospital, Bharatpur-10, 44207 Chitwan, Nepal.

Introduction: Scleral buckle surgery retains a special place in treatment of retinal detachment despite development of new and advanced vitreoretinal surgical techniques. The outcome of any retinal detachment surgery depends on correct selection of patient, type and nature of detachment, and the expertise. This study aims to evaluate various other parameters that determine the outcome of scleral buckle surgery. Read More

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November 2018

Scanning Electron Microscopy Analysis of the Anterior Capsulotomy Edge: A Comparative Study between Femtosecond Laser-Assisted Capsulotomy and Manual Capsulorhexis.

J Ophthalmol 2018 14;2018:8620150. Epub 2018 Nov 14.

Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazza Ospedale 1, 34129 Trieste, Italy.

Purpose: To compare the capsule edges ultrastructure obtained by two femtosecond laser-assisted cataract surgery (FLACS) platforms and manual continuous curvilinear capsulorhexis (CCC) using scanning electron microscopy (SEM).

Setting: Eye Clinic, University of Trieste, Italy.

Design: Experimental comparative study. Read More

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November 2018

Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation.

J Ophthalmol 2018 12;2018:6537413. Epub 2018 Nov 12.

Associate Professor, Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Purpose: To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. : 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not containing D-panthenol in the other eye, postoperatively, for 2 months. Patients were examined daily for 3 days after the procedure. Read More

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November 2018
1 Read

Comparison between Transepithelial Photorefractive Keratectomy versus Alcohol-Assisted Photorefractive Keratectomy in Correction of Myopia and Myopic Astigmatism.

J Ophthalmol 2018 12;2018:5376235. Epub 2018 Nov 12.

Ophthalmology Department, Security Forces Hospital, Riyadh, Saudi Arabia.

Purpose: The aim of the study was to compare visual acuity, refractive results, safety, and efficacy of TPRK with AAPRK as primary outcomes and surgical time, pain scores, haze levels, and healing time as secondary outcomes in TPRK and AAPRK groups.

Setting: Security Forces Hospital, Ophthalmology Department, Riyadh, Kingdom of Saudi Arabia.

Design: Prospective, nonrandomized case-control comparative study. Read More

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November 2018

Marmots do not consistently use their left eye to respond to an approaching threat but those that did fled sooner.

Curr Zool 2018 Dec 11;64(6):727-731. Epub 2018 Jan 11.

School of Life Sciences, Peking University, Beijing, China.

In many vertebrates, the brain's right hemisphere which is connected to the left visual field specializes in the processing of information about threats while the left hemisphere which is connected to the right visual field specializes in the processing of information about conspecifics. This is referred to as hemispheric lateralization. But individuals that are too predictable in their response to predators could have reduced survival and we may expect selection for somewhat unpredictable responses. Read More

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December 2018

High-Order Visual Processing, Visual Symptoms, and Visual Hallucinations: A Possible Symptomatic Progression of Parkinson's Disease.

Front Neurol 2018 27;9:999. Epub 2018 Nov 27.

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

To determine whether Parkinson disease (PD) patients with (VH) have different clinical characteristics and gray-matter volume than those with visual misperceptions (VM) or other visual symptoms (OvS). The spectrum of visual complaints in PD is broad and complex. We conducted a retrospective chart review of 525 PD patients to identify the frequency of visual symptoms and the association with clinical and radiological features. Read More

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November 2018

The Method of Silent Substitution for Examining Melanopsin Contributions to Pupil Control.

Front Neurol 2018 27;9:941. Epub 2018 Nov 27.

Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands.

The human pupillary light response is driven by all classes of photoreceptors in the human eye-the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping spectral tuning, and even a monochromatic light with a wavelength matched to the peak spectral sensitivity of a given photoreceptor will stimulate all photoreceptors. The method of silent substitution uses pairs of lights ("metamers") to selectively stimulate a given class of photoreceptors while keeping the activation of all others constant. Read More

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November 2018
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Mitochondrial Fission Is Required for Blue Light-Induced Apoptosis and Mitophagy in Retinal Neuronal R28 Cells.

Front Mol Neurosci 2018 27;11:432. Epub 2018 Nov 27.

Research Institute of Ophthalmology and Visual Sciences, Affiliated Eye Hospital of Nanchang University, Nanchang, China.

Light emitting diodes (LEDs) are widely used to provide illumination due to their low energy requirements and high brightness. However, the LED spectrum contains an intense blue light component which is phototoxic to the retina. Recently, it has been reported that blue light may directly impinge on mitochondrial function in retinal ganglion cells (RGCs). Read More

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November 2018

Spectral Properties of Brain Activity Under Two Anesthetics and Their Potential for Inducing Natural Sleep in Birds.

Front Neurosci 2018 27;12:881. Epub 2018 Nov 27.

School of Life Sciences, La Trobe University, Melbourne, VIC, Australia.

Both mammals and birds exhibit two sleep states, slow wave sleep (SWS) and rapid eye movement (REM) sleep. Studying certain aspects of sleep-related electrophysiology in freely behaving animals can present numerous methodological constraints, particularly when even fine body movements interfere with electrophysiological signals. Interestingly, under light general anesthesia, mammals and birds also exhibit slow waves similar to those observed during natural SWS. Read More

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November 2018

Novel codon 15 RHO gene mutation associated with retinitis pigmentosa.

Int Med Case Rep J 2018 20;11:339-344. Epub 2018 Nov 20.

Department of Ophthalmology, Federal Health Sciences University of Porto Alegre, Porto Alegre, Brazil,

Objective: To describe, in a multimodal way, a new RHO gene mutation with lysine-for-asparagine substitution in autosomal dominant retinitis pigmentosa.

Methods: Case report. Retrospective data analysis. Read More

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November 2018
1 Read

Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study.

Clin Ophthalmol 2018 26;12:2399-2407. Epub 2018 Nov 26.

Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France.

Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.

Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.

Methods: This was an international, prospective, and observational real-life study. Read More

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November 2018

Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation.

Clin Ophthalmol 2018 23;12:2393-2398. Epub 2018 Nov 23.

University of Alcala, Madrid, Spain.

Purpose: To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0. Read More

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November 2018

Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries.

Clin Ophthalmol 2018 26;12:2383-2391. Epub 2018 Nov 26.

Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.

Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.

Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years. Read More

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November 2018

The effect of cold tetracaine on the severity of burning sensation upon instillation.

Clin Ophthalmol 2018 20;12:2377-2382. Epub 2018 Nov 20.

Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand,

Purpose: Tetracaine is one of the most common eye drops that are used for analgesia in clinical practice. However, it causes ocular burning sensation when instilled. This study aimed to compare the effects of the cold and room temperature tetracaine on burning sensation. Read More

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November 2018
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Prevalence, site and tissue preference of myxozoan parasites infecting gills of cultured fingerlings of Indian major carps in District Fatehgarh Sahib, Punjab (India).

J Parasit Dis 2018 Dec 13;42(4):559-569. Epub 2018 Oct 13.

2Department of Zoology, Panjab University, Chandigarh, 160014 India.

A study was undertaken to investigate the prevalence rate, site preference and extent of damage caused by myxosporidian parasites in Punjab, India. During the 6 months study, 600 carp fingerlings belonging to 4 genera i.e. Read More

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December 2018

T2-relaxation mapping and fat fraction assessment to objectively quantify clinical activity in thyroid eye disease: an initial feasibility study.

Eye (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.

Imaging in thyroid eye disease (TED) is used to exclude other diagnoses, assess for apical crowding and plan surgery. But to quantify TED activity objectively, subjective clinical scoring assessments remain the norm. Magnetic resonance imaging (MRI) T2-relaxation times correlate with extra-ocular muscle (EOM) inflammation, but are confounded by signal from fat. Read More

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December 2018

Evaluation estrogen, progesteron and androgen receptor expressions in corneal epithelium in keratoconus.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Hacettepe University, Bioengineering, Ankara, Turkey.

Purpose: To evaluate the role of sex steroid hormone receptors in corneal epithelium in etiopathogenesis of keratoconus (KC).

Methods: Thirty patients with KC who were planned for corneal collagen-crosslinking and 20 patients who were planned for excimer laser for refractive errors included in this study. Corneal epitheliums were curated mechanically during surgeries. Read More

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December 2018

Clinical factors associated with contact lens dropout.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Centre for Ocular Research and Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.

Purpose: Contact lens (CL) dropout is estimated to be approximately equal to the number of new wearers per year, resulting in virtually no growth in the global CL market. The purpose of this study was to determine ocular and CL factors associated with CL dropout.

Methods: This five-site study recruited subjects 18-45 years of age who had ceased CL wear within the past 6-12 months due to discomfort. Read More

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December 2018

Effects of ranibizumab (Lucentis®) and bevacizumab (Avastin®) on human corneal endothelial cells.

BMC Ophthalmol 2018 Dec 11;18(1):316. Epub 2018 Dec 11.

Department of Ophthalmology, University of Heidelberg, Lions Eye Bank, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Ingrowth of newly formed blood and lymph vessels (angiogenesis) from the limbus region into the cornea can be treated successfully by subconjunctival application of antiangiogenic agents. Currently, there are several angiogenesis inhibitors from various manufacturers available, such as vascular endothelial growth factor (VEGF) antibodies. The aim of the study was to investigate potential cytotoxic effects of two anti-VEGF agents, ranibizumab (Lucentis®) and bevacizumab (Avastin®) on the human corneal endothelium. Read More

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December 2018
1 Read

Disconnected, fragmented, or united? a trans-disciplinary review of network science.

Authors:
César A Hidalgo

Appl Netw Sci 2016 20;1(1). Epub 2016 Jul 20.

The MIT Media Lab, Cambridge, MA USA.

During decades the study of networks has been divided between the efforts of social scientists and natural scientists, two groups of scholars who often do not see eye to eye. In this review I present an effort to mutually translate the work conducted by scholars from both of these academic fronts hoping to continue to unify what has become a diverging body of literature. I argue that social and natural scientists fail to see eye to eye because they have diverging academic goals. Read More

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July 2016
1 Read

A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

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December 2018
2 Reads

Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae.

Chemosphere 2018 Dec 5;219:155-164. Epub 2018 Dec 5.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China. Electronic address:

Deltamethrin is widely used because of its low toxicity and high efficiency. Although its potential toxicity has been reported, its effects on cardiovascular system and motor behavior and its underlying mechanisms have remained unclear. In this study, the effects of deltamethrin on the development, cardiovascular system and motor behavior of zebrafish larvae and their possible mechanisms were evaluated using the transgenic zebrafish Tg (kdrl:mCherry) and Tg(myl7:GFP). Read More

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December 2018
1 Read

Lens dose-response prediction modeling and cataract incidence in retinoblastoma patients after lens-sparing or whole-eye radiotherapy.

Int J Radiat Oncol Biol Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiation Oncology, Keck School of Medicine of USC and Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:

Purpose: We retrospectively assessed the incidence of cataracts in retinoblastoma (Rb) patients treated with either lens-sparing (LSRT) or whole-eye radiotherapy (WERT). A secondary aim of this study was to model the dose-response risk of cataract.

Methods: We reviewed 65 retinoblastoma patients treated with radiotherapy (RT) at XXXX from 1997-2015. Read More

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December 2018
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