604,071 results match your criteria Eye London England[Journal]


Adherence to Optical Safety Guidelines for Laser-Assisted Hair Removal.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: In recent years, there was a rise in ocular injuries secondary to cosmetic laser-assisted hair removal.

Purpose: To assess the level of adherence to optical safety guidelines during laser-assisted hair removal performed by nurses or physicians in private practice.

Methods: A cross-sectional study was conducted at thirty-one private laser-assisted hair removal clinics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/phpp.12473DOI Listing

A case of X-linked retinoschisis with atypical fundus appearance.

Doc Ophthalmol 2019 Apr 20. Epub 2019 Apr 20.

Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University, Elfriede-Aulhorn Strasse 7, 72076, Tübingen, Germany.

Purpose: Mutations in the RS1 gene are known to cause retinoschisis, an X-linked hereditary retinal degeneration. Here, we present a case of atypical retinoschisis with clinical findings of retinoschisis and retinitis pigmentosa.

Methods: This report is an observational case report. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10633-019-09698-3DOI Listing

Comparison between refractive outcomes between macula-on and macula-off retinal detachments after phaco-vitrectomy.

Jpn J Ophthalmol 2019 Apr 20. Epub 2019 Apr 20.

Department of Ophthalmology, School of Medicine, Pusan National University, Busan, South Korea.

Purpose: To evaluate axial length (AL) measurements and refractive outcomes in vitrectomy combined with cataract operation for rhegmatogenous retinal detachment (RRD) with wholly detached macula.

Study Design: Retrospective, consecutive, comparative, clinical study.

Methods: We reviewed the data of patients treated by vitrectomy combined with cataract operation for RRD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10384-019-00667-6DOI Listing

International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol.

BMJ Open 2019 Apr 20;9(4):e026552. Epub 2019 Apr 20.

Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Introduction: Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026552DOI Listing
April 2019
1 Read

Locked-in syndrome in Sweden, an explorative study of persons who underwent rehabilitation: a cohort study.

BMJ Open 2019 Apr 20;9(4):e023185. Epub 2019 Apr 20.

Institution of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Objective: Locked-in syndrome (LiS) is a rare condition, characterised by a complete paresis except for vertical eye movements and blinking with cognitive functions intact, commonly caused by ischaemia in the ventral pons. Previous studies have indicated that persons with LiS can live on for many years and have a good quality of life (QoL). To our knowledge, LiS has never been studied in Sweden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023185DOI Listing

Comparative evaluation of the efficacy of using monocular, binocular and panoramic night vision goggles in successful venous access in darkness.

J R Army Med Corps 2019 Apr 20. Epub 2019 Apr 20.

Emergency Department, Health Sciences University, Gulhane Research and Training Hospital, Ankara, Turkey.

Introduction: The use of night vision goggles (NVGs) by medical staff operating in active combat areas may present a tactical advantage in maintaining unit concealment. This study seeks to assess the degree to which NVG use improves speed and ease of intravenous access in comparison to no NVG use, and which NVG system (monocular, binocular or panoramic) provides the best conditions for the clinician.

Methods: Cannulation was carried out using both eyes open (BEO) and one eye open (OEO) in well-lit conditions to establish a baseline measurement. Read More

View Article

Download full-text PDF

Source
http://jramc.bmj.com/lookup/doi/10.1136/jramc-2019-001173
Publisher Site
http://dx.doi.org/10.1136/jramc-2019-001173DOI Listing
April 2019
1 Read

Engraftment of Human Stem Cell-Derived Otic Progenitors in the Damaged Cochlea.

Mol Ther 2019 Apr 2. Epub 2019 Apr 2.

CNRS UMR 7260, Aix-Marseille Université, Marseille, France; Laboratory of Bioengineering and Nanoscience, LBN, University of Montpellier, Montpellier, France. Electronic address:

Most cases of sensorineural deafness are caused by degeneration of hair cells. Although stem/progenitor cell therapy is becoming a promising treatment strategy in a variety of organ systems, cell engraftment in the adult mammalian cochlea has not yet been demonstrated. In this study, we generated human otic progenitor cells (hOPCs) from induced pluripotent stem cells (iPSCs) in vitro and identified these cells by the expression of known otic markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2019.03.018DOI Listing

Psychological and Psychosocial Interventions for Depression and Anxiety in Patients With Age-Related Macular Degeneration: A Systematic Review.

Am J Geriatr Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

Centre of Psychology, Faculty of Psychology and Educational Sciences (NN, EC), University of Porto, Porto, Portugal.

Objective: To review the current literature on psychosocial and psychological interventions to prevent and treat depression and anxiety in patients with age-related macular degeneration (AMD).

Methods: The authors conducted a systematic review of literature evaluating psychosocial and psychological interventions for depression and anxiety in patients with AMD. Primary searches of PubMed, Cochrane library, EMBASE, Global Health, Web of Science, EBSCO, and Science Direct were conducted to include all articles published up to April 21, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jagp.2019.03.001DOI Listing

Efficacy of Videostroboscopy and High-Speed Videoendoscopy to Obtain Functional Outcomes From Perioperative Ratings in Patients With Vocal Fold Mass Lesions.

J Voice 2019 Apr 17. Epub 2019 Apr 17.

Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts; Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, Massachusetts.

Objectives: A major limitation of comparing the efficacy of videostroboscopy (VS) and high-speed videoendoscopy (HSV) is the lack of an objective reference by which to compare the functional assessment ratings of the two techniques. For patients with vocal fold mass lesions, intraoperative measures of lesion size and depth may serve as this objective reference. This study compared the relationships between the pre- to postoperative change in VS and HSV visual-perceptual ratings to intraoperative measures of lesion size and depth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jvoice.2019.03.012DOI Listing

Cataract formation after application of intense focused ultrasound for facial rejuvenation.

J Fr Ophtalmol 2019 Apr 17. Epub 2019 Apr 17.

Parsian vision science research institute, Parsian Eye Clinic, Isfahan, Iran; Isfahan Eye Research Center (IERC), Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Ophthalmology, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01815512193011
Publisher Site
http://dx.doi.org/10.1016/j.jfo.2018.11.007DOI Listing
April 2019
1 Read

Reply.

Ophthalmology 2019 May;126(5):e40-e41

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2018.11.030DOI Listing

Sectoral Choroidal Hypopigmentation.

Ophthalmology 2019 May;126(5):711

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2019.02.020DOI Listing

Acute Angle Closure Glaucoma in Von Hippel-Lindau Syndrome.

Ophthalmology 2019 May;126(5):691

Department of Ophthalmology, Duke Eye Center, Duke University, Durham North Carolina.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01616420193036
Publisher Site
http://dx.doi.org/10.1016/j.ophtha.2019.02.009DOI Listing
May 2019
1 Read

Painful Dry Eye Symptoms: A Nerve Problem or a Tear Problem?

Authors:
Anat Galor

Ophthalmology 2019 May;126(5):648-651

Miami, Florida. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01616420183283
Publisher Site
http://dx.doi.org/10.1016/j.ophtha.2019.01.028DOI Listing
May 2019
1 Read

A low-cost microfluidic platform for rapid and instrument-free detection of whooping cough.

Anal Chim Acta 2019 Aug 5;1065:71-78. Epub 2019 Mar 5.

Department of Chemistry and Biochemistry, USA; Biomedical Engineering, USA; Border Biomedical Research Center, USA; Environmental Science and Engineering, University of Texas at El Paso, 500 West University Ave, El Paso, TX, 79968, USA. Electronic address:

Whooping cough also called Pertussis is a highly contagious respiratory infection that affects all age populations. Given recent pertussis outbreaks, there is an urgent need for a point-of-care (POC) device for rapid diagnosis of pertussis. Herein, we report a low-cost microfluidic POC device integrated with loop-mediated isothermal amplification (LAMP) technique for the rapid and accurate diagnosis of pertussis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00032670193025
Publisher Site
http://dx.doi.org/10.1016/j.aca.2019.03.001DOI Listing
August 2019
1 Read

Neck muscle fatigue affects performance of an eye-hand tracking task.

J Electromyogr Kinesiol 2019 Apr 10;47:1-9. Epub 2019 Apr 10.

Faculty of Health Sciences, University of Ontario Institute of Technology, 2000 Simcoe St. North, Oshawa, ON L1H 7K4, Canada. Electronic address:

Altered afferent input from the neck due to fatigue alters upper limb proprioception and is likely to impact upper limb performance accuracy. This study examined the effect of cervical extensor muscle (CEM) fatigue on eye-hand tracking accuracy in healthy participants. Twenty-four healthy right-handed individuals were randomly assigned to either a control or CEM fatigue group. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10506411183048
Publisher Site
http://dx.doi.org/10.1016/j.jelekin.2019.04.001DOI Listing
April 2019
3 Reads

Innovative techniques for the treatment of adult strabismus.

J AAPOS 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina; Department of Ophthalmology, University of California, Los Angeles; Doheny Eye Institute, Los Angeles, California.

Adult strabismus is often characterized by surgical complexity. In recent years, several innovative techniques for the management of complex strabismus have been developed. Strabismus surgeons should understand the indications for various strabismus surgical techniques in the management of these difficult cases. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10918531193008
Publisher Site
http://dx.doi.org/10.1016/j.jaapos.2018.10.018DOI Listing
April 2019
1 Read

Post-Concussion: Receded Near Point of Convergence is Not Diagnostic of Convergence Insufficiency.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Boston Children's Hospital, Boston, MA; Department of Ophthalmology, Harvard Medical School; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA.

Purpose: To determine the frequency of receded near point of convergence (NPC) in patients with chronic concussion-related symptoms, and among those with receded NPC to enumerate the frequency of convergence insufficiency and other oculomotor disorders.

Study: Design: Retrospective cross-sectional study METHODS: Clinic charts were retrospectively reviewed for the prior 3.5 years to identify all patients <21 years old who were >28 days post-concussion, had chronic concussion-related symptoms, had normal visual acuity, and received a comprehensive sensorimotor examination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.04.008DOI Listing

Eye of the Beholder: The Reinvention of Seeing.

Authors:
Richard L Prager

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiac Surgery, University of Michigan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00034975193056
Publisher Site
http://dx.doi.org/10.1016/j.athoracsur.2019.03.054DOI Listing
April 2019
1 Read

Age-related spatial differences of human lens UV filters revealed by negative ion mode MALDI imaging mass spectrometry.

Exp Eye Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Physiology, School of Medical Sciences, University of Auckland, Auckland, New Zealand. Electronic address:

Tryptophan-derived UV filters are predominantly found in the lenses of primates and humans. While protective against UV radiation, aging alters the complement and spatial distributions of human lens UV filters, and a role for UV filters has been suggested in age-related cataract formation. To establish how the spatial distributions of UV filters change in normal human lens aging, matrix assisted laser desorption/ionisation-imaging mass spectrometry (MALDI-IMS) was utilised to map the locations and relative abundance of multiple UV filters simultaneously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2019.04.016DOI Listing

Investigating the potential of carboxymethyl pullulan for protecting the rabbit eye from systematically induced precorneal tear film damage.

Exp Eye Res 2019 Apr 17. Epub 2019 Apr 17.

Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147 002, Punjab, India. Electronic address:

The present investigation was aimed to develop a rabbit model for protecting the rabbit eye from systematically induced precorneal tear film (PTF) damage, evaluation of carboxymethyl pullulan for its protective action against PTF damage and its curative potential. For the same, pullulan was modified by carboxymethylation and structural modification was confirmed by spectral attributes. Further, the carboxymethyl pullulan (CMP) solutions (0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835183070
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.017DOI Listing
April 2019
1 Read

Outcomes after Epiretinal Membrane Surgery with or Without Internal Limiting Membrane Peeling.

Ophthalmol Ther 2019 Apr 19. Epub 2019 Apr 19.

Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Introduction: The aim of this study was to assess the incidence of persistent postoperative cystoid macular edema (pCME) in patients undergoing pars plana vitrectomy with epiretinal membrane peel (ERM) only versus those with ERM peel combined with internal limiting membrane peel (ILM). Secondary endpoints of the study were to review both the central macular thickness (CMT) and visual acuity.

Methods: The patients were divided in two groups, one group in which only the ERM was peeled (n = 36 patients) and another group in which both the ERM and the ILM were removed (n = 62 patients). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40123-019-0185-7
Publisher Site
http://dx.doi.org/10.1007/s40123-019-0185-7DOI Listing
April 2019
1 Read

Comparison of the efficacy of different cell sources for transplantation in total limbal stem cell deficiency.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, 5 Yanerdao Road, Qingdao, 266071, China.

Purpose: The purpose of this study was to compare the efficacy of allogeneic cultured limbal epithelial transplantation (ACLET) and cultivated oral mucosal epithelial transplantation (COMET) in treating total limbal stem cell deficiency (LSCD).

Methods: In this retrospective cohort study, 73 patients (76 eyes) with total LSCD, including 41 patients (42 eyes) treated with ACLET and 32 patients (34 eyes) receiving COMET, were evaluated. The age, gender and injury cause of all patients were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-019-04316-zDOI Listing

Quantitative EEG measures in REM and NREM sleep are associated with AHI and nocturnal hypoxemia in men.

Sleep 2019 Apr 20. Epub 2019 Apr 20.

The Health Observatory, Adelaide Medical School, University of Adelaide, The Queen Elizabeth Hospital Campus, Woodville, South Australia, Australia.

Study Objectives: Quantitative EEG measures of sleep may identify vulnerability to obstructive sleep apnea (OSA) sequelae, however, small clinical studies of sleep microarchitecture in OSA show inconsistent alterations. We examined relationships between quantitative EEG measures during rapid eye movement (REM) and non-REM (NREM) sleep and OSA severity among a large population-based sample of men while accounting for insomnia.

Methods: All-night EEG (F4-M1) recordings from full in-home polysomnography (Embletta X100) in 664 men with no prior OSA diagnosis (age ≥40) were processed following exclusion of artefacts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/sleep/zsz092DOI Listing

Morphometric analysis in mouse scleral fibroblasts using focused ion beam/scanning electron microscopy.

Sci Rep 2019 Apr 19;9(1):6329. Epub 2019 Apr 19.

Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, Japan.

The sclera as well as the cornea forms the principal part of the outer fibrous coat of the eye, with a primary function of protecting the intraocular contents and maintaining the shape of the globe. However, the exact morphometric arrangement of scleral fibroblasts remains unclarified. The aim of this study was to observe the three-dimensional structure of the mouse scleral fibroblasts by focused ion beam/scanning electron microscopy (FIB/SEM). Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-42758-x
Publisher Site
http://dx.doi.org/10.1038/s41598-019-42758-xDOI Listing
April 2019
1 Read

Diagnosing and quantifying a common deficit in multiple sclerosis: Internuclear ophthalmoplegia.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From Amsterdam UMC (J.A.N.B., L.J.B., A.P.), Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam; Amsterdam UMC (J.A.N.B., L.J.v.R., H.S.T., A.P.), Vrije Universiteit Amsterdam, Department of Ophthalmology, Neuro-ophthalmology Expertise Center, Neuroscience Amsterdam; Onze Lieve Vrouwe Gasthuis (L.J.v.R., B.M.J.U.), Department of Ophthalmology, Amsterdam, the Netherlands; and Moorfields Eye Hospital and the National Hospital for Neurology and Neurosurgery (A.P.), London, UK.

Objective: We present an objective and quantitative approach for diagnosing internuclear ophthalmoplegia (INO) in multiple sclerosis (MS).

Methods: A validated standardized infrared oculography protocol (DEMoNS [Demonstrate Eye Movement Networks with Saccades]) was used for quantifying prosaccades in patients with MS and healthy controls (HCs). The versional dysconjugacy index (VDI) was calculated, which describes the ratio between the abducting and adducting eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007499DOI Listing

Visual attention is not limited to the oculomotor range.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Allgemeine und Experimentelle Psychologie, Department Psychologie, Ludwig-Maximilians-Universität München, 80802 München, Germany.

Both patients with eye movement disorders and healthy participants whose oculomotor range had been experimentally reduced have been reported to show attentional deficits at locations unreachable by their eyes. Whereas previous studies were mainly based on the evaluation of reaction times, we measured visual sensitivity before saccadic eye movements and during fixation at locations either within or beyond participants' oculomotor range. Participants rotated their heads to prevent them from performing large rightward saccades. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1813465116DOI Listing
April 2019
1 Read

Examiner Position in Ocular Point-of-Care Ultrasound: A Proposed Technique.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Ocular point-of-care ultrasound (POCUS) is a fast and safe non-invasive procedure used to evaluate the structural integrity and pathology of the eye. Ocular POCUS can be used for evaluation of posterior chamber and orbital pathology, including retinal detachment, vitreous detachment or hemorrhage, foreign body, lens dislocation, and increased intracranial pressure.

Discussion: The purpose of this brief communication is to describe a technique for conducting an ocular POCUS that may in some cases be easier and more comfortable by adjusting the position of the sonographer relative to the patient. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07364679193023
Publisher Site
http://dx.doi.org/10.1016/j.jemermed.2019.03.027DOI Listing
April 2019
2 Reads

A modified intraocular lens design to reduce negative dysphotopsia.

J Cataract Refract Surg 2019 Apr 16. Epub 2019 Apr 16.

retired, Orange, California, USA.

Purpose: To use ray-tracing analysis and simulated retinal illumination profiles to design an intraocular lens (IOL) that prevents or reduces negative dysphotopsia after cataract surgery.

Setting: Mayo Clinic, Rochester, Minnesota, and Simpson Optics LLC, Arlington, Texas, USA.

Design: Experimental study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08863350193004
Publisher Site
http://dx.doi.org/10.1016/j.jcrs.2019.01.019DOI Listing
April 2019
1 Read

A Review on Automatic Facial Expression Recognition Systems Assisted by Multimodal Sensor Data.

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Swinburne Data Science Research Institute, Swinburne University of Technology, Hawthorn VIC 3122, Australia.

Facial Expression Recognition (FER) can be widely applied to various research areas, such as mental diseases diagnosis and human social/physiological interaction detection. With the emerging advanced technologies in hardware and sensors, FER systems have been developed to support real-world application scenes, instead of laboratory environments. Although the laboratory-controlled FER systems achieve very high accuracy, around 97%, the technical transferring from the laboratory to real-world applications faces a great barrier of very low accuracy, approximately 50%. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/1424-8220/19/8/1863
Publisher Site
http://dx.doi.org/10.3390/s19081863DOI Listing
April 2019
2 Reads

Video-oculography eye tracking towards clinical applications: A review.

Comput Biol Med 2019 Mar 30;108:57-66. Epub 2019 Mar 30.

Research Institute for Signals, Systems and Computational Intelligence, Sinc(i), FICH-UNL/CONICET, Ruta Nac. No 168, Km 472.4 (3000), Santa Fe, Argentina.

Most neurological diseases are usually accompanied by a broad spectrum of oculomotor alterations. Being able to record and analyze these different types of eye movements would be a valuable tool to understand the functional integrity of brain structures. Nowadays, video-oculography is the most widely used eye-movements assessing method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2019.03.025DOI Listing

The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases.

Int Immunopharmacol 2019 Apr 16;72:258-263. Epub 2019 Apr 16.

Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.

The classical renin-angiotensin system (RAS) is known to be a key regulator of blood pressure as well as fluid and electrolyte homeostasis. Additionally, it is now evident that components of the RAS are produced and act locally in many tissues, including liver, kidney, heart, lung, eye, bone, reproductive organ, adipose, and adrenal tissue, and these components are collectively known as tissue RAS. Recently, several studies have shown that local bone RAS is directly involved in bone metabolism, and activation of skeletal RAS plays an important role in bone diseases, such as osteoporosis, arthritis, and deterioration as well as in fracture healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.04.023DOI Listing
April 2019
2 Reads

CD30 Aptamer-functionalized PEG-PLGA nanoparticles for the superior delivery of doxorubicin to anaplastic large cell lymphoma cells.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

School of Biological Science and Engineering, South China University of Technology, Guangzhou 510640, China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, Chinese Academy of Sciences, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Nanoparticles (NPs) conjugated with aptamers have been extensively in recent years, which can efficiently target cancer cells that improve the therapeutic effect. Aptamers (Apt) are small oligonucleotide molecule ligands have specific high-affinity. In this work, we developed a PEG-PLGA nanoparticles (NPs) encapsulated with doxorubicin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.04.013DOI Listing

Vancomycin ocular delivery systems based on glycerol monooleate reversed hexagonal and reversed cubic liquid crystalline phases.

Eur J Pharm Biopharm 2019 Apr 16. Epub 2019 Apr 16.

University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, NAWI Graz, Universitätsplatz 1, 8010 Graz, Austria. Electronic address:

Lyotropic bulk reversed hexagonal and reversed cubic liquid crystalline phases (hexagonal and cubic phases) composed of glycerol monooleate (GM) were used to design the vancomycin hydrochloridés (VHCl) delivery systems aiming to maintain VHCĺs therapeutic concentration during 24 h in the eye, locally (as an insert) and/or intravitreally (as a bulk phase injection). Bulk VHCĺs hexagonal and cubic phases were successfully prepared by melted homogenization and solvent evaporation method, and then an insert was prepared. The structural characteristics of liquid crystalline phases were studied using cross polarized light microscopy and small angle X-ray scattering technique. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpb.2019.04.009DOI Listing

Pregabalin affords retinal neuroprotection in diabetic rats: Suppression of retinal glutamate, microglia cell expression and apoptotic cell death.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology and Toxicology, Faculty of Pharmacy (girls), Al-Azhar University, Cairo, Egypt.

Pregabalin is the first drug to receive FDA approval for treating diabetic neuropathic pain. This study investigated the neuroprotective effect of pregabalin in an experimental model of diabetic retinopathy and tested some possible mechanisms underlying the putative neuroprotective effect. Male Wistar rats received streptozotocin (45 mg/kg) to induce type 1 diabetes mellitus. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835183023
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.014DOI Listing
April 2019
1 Read

Optical coherence tomography angiography (OCT-A) in an animal model of laser-induced choroidal neovascularization.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Aim of the study was to compare optical coherence tomography angiography (OCT-A) and conventional fluorescein angiography (FA) for quantitative analysis of the retinal and choroidal vasculature in the animal model of laser-induced choroidal neovascularization (CNV). Therefore, Dark Agouti rats underwent argon laser photocoagulation to induce CNV at D0. In vivo imaging using combined confocal scanner laser ophthalmoscopy (cSLO)-based FA and OCT-A (Heidelberg Engineering GmbH, Heidelberg, Germany) was performed before and immediately after laser treatment as well as at day 2, 7, 14 and 21. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2019.04.002DOI Listing

Analysis of the proteasome activity and the turnover of the serotonin 2B (HTR2B) receptor in human uveal melanoma.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

CUO-Recherche, Médecine Régénératrice, Centre de Recherche FRQS du CHU de Québec, Université Laval, Québec, Canada; Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, Canada; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Québec, QC, Canada. Electronic address:

Uveal melanoma (UM), although a very rare disease, remains a particularly aggressive type of cancer as near 50% of the UM presenting patients will also develop liver metastases within 15 years from the initial diagnostic. One of the most reliable predictive markers of UM at risk of evolving toward the formation of liver lesions is an abnormally elevated level of expression of the transcript encoding the 5-Hydroxytryptamine (serotonin) receptor 2B (HTR2B). In our previous study, we demonstrated that transcription of the HTR2B gene was under the regulatory influences of two transcription factors (TFs), NFI and RUNX1. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835193010
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.013DOI Listing
April 2019
2 Reads

Functional analysis of miR-21-3p, miR-30b-5p and miR-150-5p shuttled by extracellular vesicles from diabetic subjects reveals their association with diabetic retinopathy.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

Dept of Medical Sciences, University of Turin, Italy. Electronic address:

Microvascular dysfunctions due to altered interactions between endothelial cells (ECs) and pericytes are key-events in the pathogenesis of diabetic retinopathy. Extracellular vesicles (EVs) derived from mesenchymal stem cells cultured in diabetic-like conditions enter pericytes, cause their detachment and migration, and stimulate angiogenesis. We recently showed that EVs from diabetic patients with retinopathy have different miRNA profiling patterns from healthy controls, and determine features of retinopathy in in vitro models of retinal microvasculature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2019.04.015DOI Listing

Pharmacokinetics and tissue distribution of pilocarpine after eyelid skin application to rats.

J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Graduate School of Pharmaceutical Sciences; Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan. Electronic address:

Extending the delivery of drugs into the eyes while reducing systemic bioavailability is of utmost importance in the management of chronic ocular diseases. Topical application onto the lower eyelid skin, as an alternative to eye drops, is seen to be a valuable strategy in the treatment of chronic eye diseases. To elucidate the critical value of delivering drugs in solution onto the eyeball through the eyelid skin, pharmacokinetic studies of pilocarpine were conducted, and the results were verified using a direct pharmacodynamic study in rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2019.04.012DOI Listing

The circadian clock gene is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina.

FASEB J 2019 Apr 19:fj201801832RR. Epub 2019 Apr 19.

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201801832RRDOI Listing

Effect of Topical 1% Cyclopentolate Hydrochloride on Tear Production, Intraocular Pressure, and Pupil Size in Healthy Turkman Horses.

J Equine Vet Sci 2019 Apr 29;75:25-29. Epub 2019 Jan 29.

Member of Turkmen Horse Breeding & Consulting Co. (THBC), Jargalan, North Khorasan Province, Iran.

This study was performed to evaluate the effect of topical 1% cyclopentolate hydrochloride on tear production (STT), intraocular pressure (IOP), and vertical pupil diameter (VPD) in healthy Turkman horses. Forty eyes of 20 clinically normal horses were used for this study, which were randomly assigned to two groups. Before instillation of 1% cyclopentolate, the baseline STT, IOP, and VPD of each group were recorded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jevs.2019.01.002DOI Listing
April 2019
1 Read

Interobserver Reliability of the Animal Welfare Indicators Welfare Assessment Protocol for Horses.

J Equine Vet Sci 2019 Apr 14;75:112-121. Epub 2019 Feb 14.

Institute of Animal Breeding and Husbandry, Kiel University, Kiel, Germany.

Objective tools for the assessment of animal welfare are needed. The present study analyzed the interobserver reliability of the Animal Welfare Indicators (AWIN) welfare assessment protocol for horses to further enhance knowledge concerning reliability. Therefore, two trained observers conducted 18 assessments on farm at the same time and on the same animals. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07370806183070
Publisher Site
http://dx.doi.org/10.1016/j.jevs.2019.02.005DOI Listing
April 2019
1 Read

Eye Surface Temperature as a Potential Indicator of Physical Fitness in Ranch Horses.

J Equine Vet Sci 2019 Apr 21;75:1-8. Epub 2018 Dec 21.

UNESP, Universidade Estadual Paulista, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, São Paulo, Brazil. Electronic address:

This study aimed to investigate the use of maximum eye surface temperature (EST), recorded by infrared thermography, as an indicator of physical fitness in ranch horses. Data collection was carried out with 16 horses by recording six physical fitness biomarkers (EST, respiratory rate, creatine kinase activity [CK], and concentrations of total serum protein, plasmatic cortisol, and lactate) before and after a regular working day. We also recorded heart rate during the exercise, exercise duration, average velocity, distance traveled, and air temperature and humidity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07370806183016
Publisher Site
http://dx.doi.org/10.1016/j.jevs.2018.11.015DOI Listing
April 2019
1 Read

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model.

Emerg Infect Dis 2019 May;25(5):865-874

Lassa virus (LASV), a hemorrhagic fever virus endemic to West Africa, causes conjunctivitis in patients with acute disease. To examine ocular manifestations of LASV, we histologically examined eyes from infected guinea pigs. In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). Read More

View Article

Download full-text PDF

Source
http://wwwnc.cdc.gov/eid/article/25/5/18-1254_article.htm
Publisher Site
http://dx.doi.org/10.3201/eid2505.181254DOI Listing
May 2019
1 Read

Gordonia bronchialis-Associated Endophthalmitis, Oregon, USA.

Emerg Infect Dis 2019 May;25(5):1017-1019

Gordonia bronchialis is an aerobic actinomycetes that rarely causes infections in humans. Few reports describe Gordonia spp. causing eye-related infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2505.180340DOI Listing

Healthcare Utilization and Treatment Patterns in Diabetic Macular Edema in Korea: a Retrospective Chart Review.

J Korean Med Sci 2019 Apr 22;34(15):e118. Epub 2019 Apr 22.

Department of Ophthalmology, Daegu Catholic University Medical Center, Daegu, Korea.

Background: Limited data exist on real-world treatment patterns for diabetic macular edema (DME) in Korea. In this study, we investigated DME treatment patterns from 2009 to 2014 and the impact of baseline treatment on healthcare resource utilization and visual acuity (VA) outcomes.

Methods: A retrospective cohort chart review of DME patients treated at 11 hospital ophthalmology clinics between January 1, 2012 and December 31, 2013 was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2019.34.e118DOI Listing

A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma.

Endocr Pathol 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Box 802, Boston, MA, 02111, USA.

We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be more numerous. These cells frequently resemble sustentacular cells topographically and cytologically, possibly explaining why they have not been previously noticed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12022-019-9575-6DOI Listing

The effect of geodemographic factors on the attendance rates at a regional diabetic retinopathy treatment centre.

Ir J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Ophthalmology Department, Cork University Hospital, Cork, Ireland.

Aim: To determine whether geodemographic factors, specifically age, gender or commuting distance, affect the attendance rates of patients referred to a Diabetic Retinopathy Treatment (DRT) Centre from the Irish National Diabetic Retinal Screening (DRS) Programme.

Methods: A retrospective analysis of the first 1200 patients who were referred for ophthalmic assessment between November 2013 and June 2015 to Cork University Hospital's (CUH) DRT clinic from the DRS was completed.

Results: A total of 972 (81%) patients attended all their scheduled DRT appointments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11845-019-02009-4DOI Listing

Reviving the lost art of scleral buckling surgery for rhegmatogenous retinal detachment: evaluation of risk factors of detachments, poor physiological outcomes, and perspective from a developing country.

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841419838662. Epub 2019 Apr 7.

Lumbini Eye Institute, Lumbini, Nepal.

Purpose: To evaluate the primary anatomic and physiological success of scleral buckling surgery for rhegmatogenous retinal detachment and factors influencing its outcomes.

Methods: This is a prospective analytical study of 92 eyes that underwent scleral buckling at the Lumbini Eye Institute and Research Center, in Lumbini, Nepal. Parameters evaluated which could influence the outcome of the surgery included the lens status, duration of symptoms, locations of breaks, the extent of retinal detachment, and preoperative proliferative vitreoretinopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2515841419838662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454650PMC
April 2019
1 Read
  • Page 1 of 12082