595,287 results match your criteria Eye & Contact Lens: Science and Clinical Practice[Journal]


Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5957-5964

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan, United States.

Purpose: To test the hypothesis that mitochondrial respiration contributes to local changes in hydration involved in phototransduction-driven expansion of outer retina, as measured by structural responses on optical coherence tomography (OCT) and diffusion magnetic resonance imaging (MRI).

Methods: Oxygen consumption rate and mitochondrial reserve capacity of freshly isolated C57BL/6 and 129S6/SvEvTac mouse retina were measured using a Seahorse Extracellular Flux Analyzer. Light-stimulated outer retina layer water content was determined by proton density MRI, structure and thickness by ultrahigh-resolution OCT, and water mobility by diffusion MRI. Read More

View Article
December 2018

Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5941-5956

Applied Genetic Technologies Corporation, Alachua, Florida, United States.

Purpose: Prospective evaluation of patients with X-linked retinoschisis (XLRS).

Methods: Fifty-six males XLRS patients, age ≥7 years, had retinal structure and function tests performed every 6 months during an 18-month period.

Results: Best corrected visual acuity (BCVA) was abnormal (mean ± SD logMAR 0. Read More

View Article
December 2018
1 Read

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5912-5923

Dr. Nasser Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, Department of Ophthalmology, McKnight Vision Research Center, University of Miami School of Medicine, Miami, Florida, United States.

Purpose: We characterize the effect of bimatoprost on orbital adipose tissue in thyroid-associated orbitopathy (TAO) with clinicopathologic correlation.

Methods: Orbital adipose-derived stem cells (OASCs) from types 1 and 2 TAO and control patients with and without exposure to 1 μm bimatoprost were examined via immunohistochemistry, RT-PCR, and Western blot for cell viability, migration capacity, lipid content, adipocyte morphology, mitochondrial content, and levels of adipogenic markers. A retrospective chart review was performed for clinicopathologic correlation. Read More

View Article
December 2018
1 Read

Vestibular dysfunction as cortical damage with amyotrophic lateral sclerosis.

J Neurol Sci 2018 Dec 5;397:4-8. Epub 2018 Dec 5.

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Cortical damage in areas such as the frontal lobe is reported in amyotrophic lateral sclerosis (ALS). However, aside from executive dysfunction, the pathological significance of this cortical damage has yet to be clarified. The present study investigated the effects of cortical damage on vestibular function in ALS. Read More

View Article
December 2018

Vernal Keratoconjunctivitis.

Surv Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is IgE mediated; however, there may be non-IgE and certain non-specific hypersensitivity mechanisms. Read More

View Article
December 2018

Risk Factors for Severe Dry Eye Disease: Crowdsourced Research Using DryEyeRhythm.

Ophthalmology 2018 Dec 11. Epub 2018 Dec 11.

Juntendo University Faculty of Medicine, Department of Ophthalmology, Tokyo Japan.

This large-scale crowdsourced study using the iPhone application DryEyeRhythm identified the risk factors for severe dry eye disease-type symptoms, which included female sex, collagen disease, hay fever, depression, current contact-lens use, extended screen time, and smoking. Read More

View Article
December 2018

Insufficient compensation for self-motion during perception of object speed: The vestibular Aubert-Fleischl phenomenon.

J Vis 2018 Dec;18(13)

German Center for Vertigo and Balance Disorders (DSGZ), University Hospital of Munich, Ludwig Maximilian University, Munich, Germany.

To estimate object speed with respect to the self, retinal signals must be summed with extraretinal signals that encode the speed of eye and head movement. Prior work has shown that differences in perceptual estimates of object speed based on retinal and oculomotor signals lead to biased percepts such as the Aubert-Fleischl phenomenon (AF), in which moving targets appear slower when pursued. During whole-body movement, additional extraretinal signals, such as those from the vestibular system, may be used to transform object speed estimates from a head-centered to a world-centered reference frame. Read More

View Article
December 2018
1 Read

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode-Based Retinal Prosthesis.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5885-5892

Jacobs Retina Center at Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, California, United States.

Purpose: For more than 20 years, there has been an international, multidisciplinary effort to develop retinal prostheses to restore functional vision to patients blinded by retinal degeneration. We developed a novel subretinal prosthesis with 1512 optically addressed silicon nanowire photodiodes, which transduce incident light into an electrical stimulation of the remaining retinal circuitry. This study was conducted to evaluate the efficacy of optically driving the subretinal prosthesis to produce visual cortex activation via electrical stimulation of the retina. Read More

View Article
December 2018

Serological and PCR-based markers of ocular Chlamydia trachomatis transmission in northern Ghana after elimination of trachoma as a public health problem.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0007027. Epub 2018 Dec 14.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Validation of elimination of trachoma as a public health problem is based on clinical indicators, using the WHO simplified grading system. Chlamydia trachomatis (Ct) infection and anti-Ct antibody responses (anti-Pgp3) have both been evaluated as alternative indicators in settings with varying levels of trachoma. There is a need to evaluate the feasibility of using tests for Ct infection and anti-Pgp3 antibodies at scale in a trachoma-endemic country and to establish the added value of the data generated for understanding transmission dynamics in the peri-elimination setting. Read More

View Article
December 2018

SEQUENTIAL CHANGES IN HYDROXYCHLOROQUINE RETINOPATHY UP TO 20 YEARS AFTER STOPPING THE DRUG: Implications for Mild Versus Severe Toxicity.

Retina 2018 Dec 13. Epub 2018 Dec 13.

Byers Eye Institute at Stanford, Palo Alto, California.

Purpose: To characterize the stability or progression of different stages of hydroxychloroquine (HCQ) retinopathy up to 20 years after stopping the drug.

Methods: We reviewed findings from 13 patients with initial HCQ retinopathy classified as early (patchy photoreceptor damage), moderate (ring of photoreceptor thinning or scotoma), or severe (retinal pigment epithelial [RPE] damage). Patients had been off HCQ for as many as 14 years at initial examination and were subsequently followed for 5 years to 8 years with repeated fundus autofluorescence and spectral domain optical coherence tomography. Read More

View Article
December 2018

DRUSEN SUBTYPES AND CHOROIDAL CHARACTERISTICS IN ASIAN EYES WITH TYPICAL NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Retina 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.

Purpose: To investigate the prevalence of pachydrusen, soft drusen, and subretinal drusenoid deposits in eyes with different neovascular age-related macular degeneration (nAMD) subtypes, determine the relationship between each drusen type and the choroidal thickness, and analyze the distinct features of each nAMD subtype according to the drusen type.

Methods: Medical records involving 454 eyes from 454 patients with nAMD were retrospectively reviewed. The prevalence of each drusen type and the choroidal thickness and choroidal characteristics were evaluated according to the nAMD subtype. Read More

View Article
December 2018
1 Read

VESSEL DENSITY OF SUPERFICIAL, INTERMEDIATE, AND DEEP CAPILLARY PLEXUSES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Retina 2018 Dec 6. Epub 2018 Dec 6.

Service d'Ophtalmologie, Hôpital Lariboisière, AP-HP, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Sorbonne Paris Cité, France.

Purpose: To provide values of retinal vessel density (VD) in the three retinal capillary plexuses, foveal avascular zone (FAZ) area, and retinal layer thickness in a cohort of healthy subjects.

Methods: The optical coherence tomography angiography maps of 148 eyes of 84 healthy subjects, aged 22 to 76 years, were analyzed for measuring VD of the retinal capillary plexuses, using the Optovue device comprising a projection artifact removal algorithm. Foveal avascular zone metrics were measured, and the relationship between optical coherence tomography angiography findings and age, sex, and image quality was studied. Read More

View Article
December 2018

Change in Lower Eyelid Position After Ptosis Repair in Patients With Unilateral Myogenic Versus Aponeurotic Blepharoptosiss.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To compare preoperative and postoperative lower eyelid scleral show in patients with unilateral myogenic (MP) and aponeurotic (AP) ptosis, analyze the factors correlated with them, and assess the rate of postoperative lower eyelid symmetry in both groups.

Methods: Patients (older than 5 years old) with unilateral MP (58) and AP (20) were included from June 2015 to April 2017. Excluded were patients with previous eyelid surgery, strabismus, levator function of ≤3, and associated procedures. Read More

View Article
December 2018

Ocular Considerations in Face Transplantation: Report of 2 Cases and Review of the Literature.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

The Hansjörg Wyss Department of Plastic Surgery and.

Purpose: Periorbital injuries are common in face transplantation (FT) candidates. It is therefore essential that the ophthalmologist play a central role in the multidisciplinary treatment of these patients. In this study, the authors perform a comprehensive review of all procedures involving periorbital components, provide an update for the ophthalmology community regarding the current state of the field, and present 2 cases. Read More

View Article
December 2018
1 Read

Bony Orbital Volume Expansion in Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

Doheny Eye Institute, Division of Orbital and Ophthalmic Plastic Surgery, University of California-Los Angeles, Los Angeles, California, U.S.A.

Purpose: To quantify changes to the bony orbital volume (BOV) in patients with thyroid eye disease (TED) relative to normal controls.

Methods: In this case-control study, all patients affected with TED seen over a 2-year period were screened for study entry. Eligible participants were adults with clinical evidence of TED and CT scans of their orbits obtained during the course of their routine care. Read More

View Article
December 2018

Eye Tracking as a Proxy for Perceptual Evaluation of Repaired Cleft Lip.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

UT Southwestern Medical Center.

Human interactions begin with near-instantaneous visual evaluation of the face, modifying emotional responses and social behavior toward the person. Eye-tracking technology can provide a potential window into how humans undertake this evaluation, and the threshold of whether a face containing a craniofacial difference is perceived as "normal." This study's main questions were whether gaze patterns differ from normal when evaluating children with craniofacial differences, and whether these gaze patterns vary with different levels of craniofacial deformity. Read More

View Article
December 2018

Fourier Analysis of Corneal Irregular Astigmatism Due to the Anterior Corneal Surface in Dry Eye.

Eye Contact Lens 2018 Dec 11. Epub 2018 Dec 11.

Departments of Innovative Visual Science (S.K., K.M.), and Ophthalmology (S.K., N.M., M.O., S.A., Y.T., K.M., K.N.), Osaka University Graduate School of Medicine, Osaka, Japan; Research and Development Division (Y.T.), Rohto, Kyoto, Japan; and Department of Ophthalmology, Icahn School of Medicine at Mount Sinai (S.D.K.), New York, NY.

Objectives: To evaluate corneal irregular astigmatism due to the anterior corneal surface using Fourier harmonic analysis with a Placido ring-based corneal topographer (Placido-based topographer) and three-dimensional anterior segment optical coherence tomography (OCT) in dry eyes.

Methods: Forty-four eyes of 44 subjects with dry eye and 20 eyes of 20 normal control subjects were enrolled. Corneal topographic data were obtained using a Placido-based topographer and OCT. Read More

View Article
December 2018

Comparison of Tri-folded and Scroll-Based Graft Viability in Preloaded Descemet Membrane Endothelial Keratoplasty.

Cornea 2018 Dec 13. Epub 2018 Dec 13.

Wilmer Eye Institute at Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: To compare corneal endothelial damage associated with 2 techniques for preloaded Descemet membrane endothelial keratoplasty (DMEK): a tri-folded graft stored in a plastic cartridge designed for DMEK and a scrolled graft stored in a modified Jones Tube, at the time of preparation and after shipping.

Methods: DMEK grafts were prepared at the Rocky Mountain Lions Eye Bank. The grafts were either tri-folded and loaded in a plastic cartridge or scrolled and loaded into a modified Jones Tube. Read More

View Article
December 2018

The impact of anti-vascular endothelial growth factor agents on visual impairment/blindness prevention in patients with diabetic macular edema and on associated patient and caregiver burden in Japan.

J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.

e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.

Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.

Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More

View Article
December 2018

Windows to functional decline: Naturalistic eye movements in older and younger adults.

Psychol Aging 2018 Dec;33(8):1215-1222

Department of Communication Sciences and Disorders, Temple University.

Subtle changes in everyday tasks precede and predict future disability in older adults. Eye tracking may provide a sensitive tool for detecting subtle disruption of everyday task performance and informing the mechanism(s) of breakdown. We tracked eye movements of healthy older adults (OA, n = 24) and younger adults (YA, n = 25) while they passively viewed a naturalistic scene (Passive Viewing condition) and then verbally reported the necessary steps for achieving a task goal (e. Read More

View Article
December 2018

[Endoscopic keel placementto treat and prevent-bilateral vocal cord adhension].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1821-1825

Department of Otorhinolaryngology Head and Neck Surgery, Eye Ear Nose Throat Hospital of Fudan University, Shanghai, 200031, China.

To investigate the effectiveness of endoscopic keel placement for the prevention and treatment of bilateral vocal cord adhesion. There are 47 cases with bilateral vocal cord lesions and 38 cases with laryngeal adhesion in this study. Bilateral vocal cord lesions were removed and laryngeal adhesion was cut and divided. Read More

View Article
December 2018

[Involvement of Th17/Treg imbalance in bacterial biofilm induced chronic rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1870-1875

Department of Otolaryngology, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China.

The aim of this study is to investigate the involvement of Th17/Treg imbalance in the pathogenesis of bacterial biofilm (BBF) induced chronic rhinosinusitis(CRS). CRS nasal sinus mucosa was collected, and BBF was examined by BacLight/CSLM detection. Forty CRS cases(20 BBF positive cases and 20 negative cases) and 10 controls were enrolled. Read More

View Article
December 2018
1 Read

Dry eye symptoms and associated risk factors among adults aged 50 or more years in Central Mexico.

Salud Publica Mex 2018 Sep-Oct;60(5):520-527

Departamento de Epidemiología Ocular y Salud Visual, Instituto de Oftalmología Conde de Valenciana. Mexico City, Mexico.

Objective: To determine the prevalence of dry eye symptoms (DES) and associated risk factors among adults in Tlaxcala, Mexico.

Materials And Methods: A cross-sectional population-based study that included 1 508 individuals aged ≥50 years who answered the Dry Eye Questionnaire (DEQ5), with a score ranging between 0 and 22; the following categories were defined: no DES (<6); mild-moderate DES (6 to 11) and severe DES (≥12).

Results: The prevalence of DES was 41. Read More

View Article

Promoting Eye Health in Low-Resource Areas by "Doing More With Less".

Asia Pac J Ophthalmol (Phila) 2018 Dec 12. Epub 2018 Dec 12.

Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

View Article
December 2018
1 Read

Management of Postoperative Ocular Hypotony after Tube Surgery by Stenting Using Two 5-0 Nylon Threads.

Korean J Ophthalmol 2018 Dec;32(6):523-524

Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

View Article
December 2018

Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography.

Korean J Ophthalmol 2018 Dec;32(6):506-516

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.

Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More

View Article
December 2018

Comparison of Intraocular Lens Power Calculation Methods Following Myopic Laser Refractive Surgery: New Options Using a Rotating Scheimpflug Camera.

Korean J Ophthalmol 2018 Dec;32(6):497-505

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: To evaluate and compare published methods of calculating intraocular lens (IOL) power following myopic laser refractive surgery.

Methods: We performed a retrospective review of the medical records of 69 patients (69 eyes) who had undergone myopic laser refractive surgery previously and subsequently underwent cataract surgery at Samsung Medical Center in Seoul, South Korea from January 2010 to June 2016. None of the patients had pre-refractive surgery biometric data available. Read More

View Article
December 2018

Factors Influencing Visual Field Recovery after Transsphenoidal Resection of a Pituitary Adenoma.

Korean J Ophthalmol 2018 Dec;32(6):488-496

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Purpose: This study aimed to analyze the factors influencing visual field recovery after transsphenoidal approach-tumor resection (TSA-TR) in pituitary adenoma patients with visual field defects (VFDs).

Methods: We retrospectively evaluated 102 eyes of 102 patients with VFDs induced by pituitary adenomas who underwent TSA-TR between January 2010 and December 2015. All patients had been observed for more than one year. Read More

View Article
December 2018

Horizontal Effects of 10-mm Inferior Oblique Recession versus 14-mm Inferior Oblique Recession.

Korean J Ophthalmol 2018 Dec;32(6):478-482

Kim's Eye Hospital, Seoul, Korea.

Purpose: The aim of this study was to investigate the quantitative effect of inferior oblique (IO) 10- and 14-mm recession on postoperative horizontal deviation.

Methods: Patients (22 men and 18 women) who underwent IO recession were divided into two groups for comparison studies: group 1 (10-mm IO recession, 15 patients) and group 2 (14-mm IO recession, 25 patients). Preoperative and postoperative horizontal deviations were measured, and the resulting horizontal deviations from the 10- and 14-mm IO recession surgeries were compared. Read More

View Article
December 2018

Anti-vascular Endothelial Growth Factor Treatment of Retinopathy of Prematurity: Efficacy, Safety, and Anatomical Outcomes.

Korean J Ophthalmol 2018 Dec;32(6):451-458

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy, safety, and anatomical outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) treatment of retinopathy of prematurity (ROP).

Methods: We performed a retrospective review of intravitreal anti-VEGF (bevacizumab or ranibizumab) treatment of 153 eyes (83 infants) diagnosed with ROP at two tertiary hospitals from June 2011 to January 2017. The primary outcome was the rate of recurrence requiring additional treatment; secondary outcomes included incidence of major complications and final refractive error. Read More

View Article
December 2018

Evaluation of Tear Film Lipid Layer Thickness Measurements Obtained Using an Ocular Surface Interferometer in Nasolacrimal Duct Obstruction Patients.

Korean J Ophthalmol 2018 Dec;32(6):445-450

Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Purpose: To compare the tear film lipid layer thickness (LLT) between patients with incomplete nasolacrimal duct obstruction (NLDO) and normal controls and to analyze the changes in tear film LLT and blinking pattern after silicone tube intubation in NLDO patients.

Methods: We reviewed the medical records of 68 eyes in 52 incomplete NLDO patients who underwent silicone tube intubation from January 2017 to July 2017. The LLT, blinking pattern, and Meibomian gland image were measured with the LipiView II ocular surface interferometer. Read More

View Article
December 2018

An N-terminal heterozygous missense CASK mutation is associated with microcephaly and bilateral retinal dystrophy plus optic nerve atrophy.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Virginia Tech Carilion Research Institute, Roanoke, Virginia.

Heterozygous loss-of-function mutations in the X-linked gene CASK are associated with mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) and ophthalmological disorders including optic nerve atrophy (ONA) and optic nerve hypoplasia (ONH). Recently, we have demonstrated that CASK mice display ONH with 100% penetrance but exhibit no change in retinal lamination or structure. It is not clear if CASK loss-of-function predominantly affects retinal ganglion cells, or if other retinal cells like photoreceptors are also involved. Read More

View Article
December 2018

Communicative Hand-Waving Gestures Facilitate Object Learning in Preverbal Infants.

Dev Sci 2018 Dec 14:e12787. Epub 2018 Dec 14.

Department of Psychology, Otemon Gakuin University, 2-1-15 Nishiai, Ibaraki, Osaka, 567-8502, JAPAN.

The theory of natural pedagogy has proposed that infants can use ostensive signals, including eye contact, infant-directed speech, and contingency to learn from others. However, the role of bodily gestures, such as hand-waving, in social learning has been largely ignored. To address this gap in the literature, this study sought to determine whether 4-month-old infants exhibited a preference for horizontal or vertical (control) hand-waving gestures. Read More

View Article
December 2018

Genotype, extrapyramidal features and severity of variant Ataxia-Telangiectasia.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Ataxia Telangiectasia Service, Respiratory Support and Sleep Centre, Papworth Hospital. Papworth Everard, Cambridge, CB23 3RE, UK.

Objective: Variant Ataxia-Telangiectasia is caused by mutations that allow some retained ATM kinase activity. Here, we describe the clinical features of the largest established cohort of individuals with variant Ataxia-Telangiectasia and explore genotype-phenotype correlations.

Methods: Cross-sectional data were collected retrospectively. Read More

View Article
December 2018
1 Read

Optic Disc Coloboma in children - prevalence, clinical characteristics and associated morbidity.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Purpose: The aim of the study was to report prevalence, ocular outcome, neurological characteristics, cognitive and behavioural problems in children with optic disc coloboma (ODC).

Methods: This was a population-based, cross-sectional study of 31 children between 2 and 18 years of age diagnosed with ODC. The children were part of a larger cohort of 184 children with congenital optic disc malformations. Read More

View Article
December 2018

Changes in Australian practice patterns for glaucoma management.

Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

South Australian Institute of Ophthalmology, The University of Adelaide, South Australia, Australia.

Importance: The demand for glaucoma care is projected to increase significantly with the ageing population.

Background: To characterise trends in Australian practice patterns for glaucoma management over the 15-year period between 2003 and 2017.

Design: Retrospective audit. Read More

View Article
December 2018

Remifentanil patient-controlled analgesia (PCA) in labour - in the eye of the storm.

Authors:
A A Melber

Anaesthesia 2018 Dec 14. Epub 2018 Dec 14.

Department of Anaesthesiology, Spital Münsingen, Insel Gruppe AG, Münsingen, Switzerland.

View Article
December 2018

Unilateral neglect post stroke: Eye movement frequencies indicate directional hypokinesia while fixation distributions suggest compensational mechanism.

Brain Behav 2018 Dec 12:e01170. Epub 2018 Dec 12.

Department of Psychology, University of Oslo, Oslo, Norway.

Introduction: Eye movements and spatial attention are closely related, and eye-tracking can provide valuable information in research on visual attention. We investigated the pathology of overt attention in right hemisphere (RH) stroke patients differing in their severity of neglect symptoms by using eye-tracking during a dynamic attention task.

Methods: Eye movements were recorded in 26 RH stroke patients (13 with and 13 without unilateral spatial neglect, and a matched group of 26 healthy controls during a Multiple Object Tracking task. Read More

View Article
December 2018
1 Read

Sharpening the focus on ophthalmology teaching: has anything changed?

Authors:
Catherine Green

Clin Exp Ophthalmol 2018 Dec;46(9):981-983

Royal Australian and New Zealand College of Ophthalmologists, Sydney, New South Wales, Australia.

View Article
December 2018

Anti-predator behavior by a nesting hummingbird in response to a caterpillar with eyespots.

Ecology 2018 Dec 12. Epub 2018 Dec 12.

Campanario Biological Station, Osa Peninsula, Costa Rica.

Caterpillars and adults of a variety of butterflies and moths have eye-like spots (Janzen et al. 2010) that deter potential predators (Stevens et al. 2007, Blut et al. Read More

View Article
December 2018
1 Read

PACAP through EGFR transactivation preserves human corneal endothelial integrity.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Biomedical and Biotechnological Sciences, Section of Human Anatomy and Histology, University of Catania, Catania, Italy.

The corneal endothelium is composed of a single hexagonal-shaped cells layer adherent to the Descemet's membrane. The primary function of these cells is maintaining of tissue clarity by regulating its hydration. Trauma, aging or other pathologies cause their loss, counterbalanced by enlargement of survived cells unable to guarantee an efficient fluid pumping to and from the stroma. Read More

View Article
December 2018

Curcumin: A new candidate for retinal disease therapy?

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

The retina is the neural portion and light-sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light-sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. Read More

View Article
December 2018
1 Read

Larval development of mandi-pintado Pimelodus britskii (Siluriformes: Pimelodidae).

J Fish Biol 2018 Dec 11. Epub 2018 Dec 11.

Universidade Estadual Paulista, Programa de Pós-graduação em Aquicultura do Centro de Aquicultura, São Paulo, Brazil.

This study investigated the morphology, morphometric and meristic characters of 117 larval Pimelodus britskii showing early development of head, eye, barbel and snout. Body and mouth pigmentation increased throughout development; the mouth was ventrally situated in the yolk-sac stage, becoming subterminal afterwards, and an embryonic fin was visible in all four stages observed. Post-flexion larval P. Read More

View Article
December 2018

CD83 CCR7 NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis.

J Cell Mol Med 2018 Dec 8. Epub 2018 Dec 8.

Institute of Basic medicine, Shandong Academy of medical Sciences, Jinan, China.

Natural killer (NK) cells have been reported to play a pathological role in autoimmune uveitis. However, the mechanisms regarding NK cells in uveitis and factors that affect NK-cell activation in this condition remain unclear. Here, we report that the number of CD3 NK1. Read More

View Article
December 2018

Skeletons of the Eye: An Evolutionary and Developmental Perspective.

Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.

Mount Saint Vincent University, Halifax, Nova Scotia, Canada.

The ocular skeleton, composed of the scleral cartilage and scleral ossicles, is present in many vertebrates. The morphology of the scleral cartilage and ossicles varies within different extant reptiles (including birds) and also varies dramatically from the morphology in extant teleosts. This incredible range of diverse morphologies is the result of millions of years of evolution. Read More

View Article
December 2018
1 Read

SOX2 regulates P63 and stem/progenitor cell state in the corneal epithelium.

Stem Cells 2018 Dec 10. Epub 2018 Dec 10.

Department of Genetics and Developmental Biology, The Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa, Israel.

Mutations in key transcription factors SOX2 and P63 were linked with developmental defects and post-natal abnormalities such as corneal opacification, neovascularization and blindness. The latter phenotypes suggest that SOX2 and P63 may be involved in corneal epithelial regeneration. While P63 has been shown to be a key regulator of limbal stem cells (LSCs), the expression pattern and function of SOX2 in the adult cornea remained unclear. Read More

View Article
December 2018

Optical coherence tomography angiography of non-exudative choroidal neovascularization.

Eye Sci 2016 Dec;31(4):243-245

Casey Eye Institute, Department of Ophthalmology, Oregon Health and Science University, Portland, OR, USA.

View Article
December 2016
1 Read

Visuospatial Integration and Hand-Tool Interaction in Cognitive Archaeology.

Curr Top Behav Neurosci 2018 Dec 15. Epub 2018 Dec 15.

Sociograph Marketing Science Consulting, Valladolid, Spain.

Testing cognitive hypotheses in extinct species can be challenging, but it can be done through the integration of independent sources of information (e.g., anatomy, archaeology, neurobiology, psychology), and validated with quantitative and experimental approaches. Read More

View Article
December 2018

Statistical learning of anomalous regions in complex faux X-ray images does not transfer between detection and discrimination.

Cogn Res Princ Implic 2018 Dec 13;3(1):48. Epub 2018 Dec 13.

Department of Psychology, University of Minnesota, 75 East River Road, S506 Elliott Hall, Minneapolis, MN, 55455, USA.

The visual environment contains predictable information - "statistical regularities" - that can be used to aid perception and attentional allocation. Here we investigate the role of statistical learning in facilitating search tasks that resemble medical-image perception. Using faux X-ray images, we employed two tasks that mimicked two problems in medical-image perception: detecting a target signal that is poorly segmented from the background; and discriminating a candidate anomaly from benign signals. Read More

View Article
December 2018

A Case of Acute Granulomatous Conjunctivitis Caused by Cat-transmitted Sporothrix schenckii.

Cureus 2018 Oct 8;10(10):e3428. Epub 2018 Oct 8.

Ophthalmology, School of Medical Sciences/Universiti Sains Malaysia, Kota Bharu, MYS.

In human, sporotrichosis infection commonly manifests as skin lesions through direct inoculation. It is rarely associated with ocular manifestation via a zoonotic transmission. We describe a young lady who presented with acute left eye granulomatous conjunctivitis who had a history of exposure to her sick cat diagnosed with sporotrichosis infection. Read More

View Article
October 2018
  • Page 1 of 11906