8,443 results match your criteria Eye[Journal]


Comment on "Effectiveness and safety of accelerated (9 mW/cm) corneal collagen cross-linking for progressive keratoconus: a 24-month follow-up".

Eye (Lond) 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1038/s41433-019-0370-xDOI Listing
February 2019

Refractive correction with multifocal intraocular lenses after radial keratotomy.

Eye (Lond) 2019 Feb 15. Epub 2019 Feb 15.

Optics and Optometry and Vision Sciences Department, Faculty of Physics, University of Valencia, Valencia, Spain.

Purpose: To assess visual and refractive results of multifocal intraocular lens (IOLs) implantation for refractive correction after radial keratotomy (RK).

Methods: In a retrospective non-comparative interventional case series, we analyzed the outcomes of multifocal IOL implantation performed in the context of cataract or refractive lens exchange surgery following RK. A total of 17 eyes from nine patients were included in the study. Read More

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http://dx.doi.org/10.1038/s41433-019-0364-8DOI Listing
February 2019

Invasive sino-orbital fungal infections in immunocompetent patients: a clinico-pathological study.

Eye (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Orbit, Oculoplasty & Ocular Oncology, Aravind Eye Hospital, Madurai, India.

Objective: Invasive sino-orbital fungal infections in immunocompetent patients are a rare clinical entity; the diagnosis and management of which is challenging. We present a large case series of invasive sino-orbital fungal granulomas in patients without pre-existing systemic immunocomprimising condition.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1038/s41433-019-0358-6DOI Listing
February 2019

Repeated injections of botulinum toxin-A for epiphora in lacrimal drainage disorders: qualitative and quantitative assessment.

Eye (Lond) 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Purpose: To report the outcome of repeated botulinum toxin-A (BTA) injections in the lacrimal glands in patients with epiphora.

Methods: We performed retrospective chart review of patients who were injected with 2.5 units of BTA in the lacrimal gland. Read More

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http://dx.doi.org/10.1038/s41433-019-0362-xDOI Listing
February 2019

"Numbers sometimes lie"- refractive surprise following IOL mislabeling by the manufacturer.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, General Hospital Klagenfurt, Klagenfurt, Austria.

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http://dx.doi.org/10.1038/s41433-019-0367-5DOI Listing
February 2019

Needles as a source of silicone oil during intravitreal injection.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Federal University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1038/s41433-019-0365-7DOI Listing
February 2019

Consulting the patients: Avastin in the treatment of Wet AMD (Part II).

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Betsi Cadwaladr University Health Board, Abergele Hospital, Abergele, UK.

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http://dx.doi.org/10.1038/s41433-019-0366-6DOI Listing
February 2019

Acquired onset of third, fourth, and sixth cranial nerve palsies in children and adolescents.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: To describe the causes of third, fourth, and sixth cranial nerve palsies in children and adolescents.

Methods: In this retrospective case series, a total of 66 patients aged 0-19 years with third, fourth, and sixth cranial nerve palsies seen in strabismus and neuro-ophthalmic practice from 2010 to 2017 were included. Causes of palsies were determined based on clinical assessment, high-resolution magnetic resonance imaging (MRI), and laboratory work-up. Read More

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http://dx.doi.org/10.1038/s41433-019-0353-yDOI Listing
February 2019

Relationship between body fat and diabetic retinopathy in patients with type 2 diabetes: a nationwide survey in Korea.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: To evaluate the association of body mass index (BMI), waist circumference, and body fat with diabetic retinopathy (DR) in Korean patients with type 2 diabetes.

Methods: Among the 1130 participants 19 years of age or older with type 2 diabetes enrolled in the nationwide survey, a total of 887 participants were included in the analyses after excluding patients with ungradable fundus images. The presence and severity of DR were graded with seven-field fundus photographs. Read More

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http://dx.doi.org/10.1038/s41433-019-0352-zDOI Listing
February 2019

Evaluation of TGFBI corneal dystrophy and molecular diagnostic testing.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK.

To date, 70 different TGFBI mutations that cause epithelial-stromal corneal dystrophies have been described. At present one commercially available test examines for the five most common of these mutations: R124H, R124C, R124L, R555W, and R555Q. To expand the capability of identifying the causative mutation in the remaining cases, 57 mutations would need to be added. Read More

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http://dx.doi.org/10.1038/s41433-019-0346-xDOI Listing
February 2019

Yield of screening blood work and MRI of the brain and orbits in the work-up of unilateral chronic optic neuropathy.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

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http://dx.doi.org/10.1038/s41433-018-0326-6DOI Listing
February 2019

Using smartphone-delivered stereoscopic vision in microsurgery: a feasibility study.

Eye (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Ophthalmology Department, Singleton Hospital, Sketty Lane, Sketty, Swansea, SA2 8QA, UK.

Background: Many surgical specialties are increasingly looking towards robot-assisted surgeries to improve patient outcome. Surgeons conducting robot-assisted operations require real-time surgical view. Ophthalmic robots can lead to novel vitreoretinal treatments, such as cannulating retinal vessels or even gene delivery to targeted retinal cells. Read More

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http://www.nature.com/articles/s41433-019-0356-8
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http://dx.doi.org/10.1038/s41433-019-0356-8DOI Listing
February 2019
1 Read

The prevalence of visually significant cataract in the Australian National Eye Health Survey.

Eye (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, Melbourne, VIC, Australia.

Purpose: To describe the prevalence of visually significant cataract in Indigenous and non-Indigenous Australians.

Methods: A total of 3098 non-Indigenous Australians aged 50 years and over and 1738 Indigenous Australians aged 40 years and over, residing in 30 randomly selected Australian sites, were examined as part of the population-based National Eye Health Survey (NEHS). For those with visual acuity worse than 6/12, photos of the anterior and posterior segment were taken with a nonmydriatic fundus camera and assessed for cataract. Read More

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http://dx.doi.org/10.1038/s41433-019-0354-xDOI Listing
February 2019

Sirolimus (rapamycin) for the targeted treatment of the fibrotic sequelae of Graves' orbitopathy.

Eye (Lond) 2019 Feb 12. Epub 2019 Feb 12.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Background: Rapamycin (alternatively known as sirolimus) is a macrolide immunosuppressant commonly used for organ transplantation. It acts both on lymphocytes through the mechanistic target of rapamycin (mTOR) pathway to reduce their sensitivity to interleukin-2 (IL-2) and, importantly, also has anti-fibrotic properties by acting on myofibroblasts. The latter have been implicated in the pathogenesis of thyroid eye disease (TED). Read More

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http://dx.doi.org/10.1038/s41433-019-0340-3DOI Listing
February 2019

Going paperless: improved cataract surgery outcome data quality in a new fully electronic unit.

Eye (Lond) 2019 Feb 11. Epub 2019 Feb 11.

Moorfields Eye Centre at Croydon University Hospital, 530 London Road, Thornton Heath, Surrey, CR7 7YE, UK.

Objectives: To report outcome data on the first 5000 consecutive cataract cases at a new paperless eye unit and benchmark against the Royal College of Ophthalmologists' National Ophthalmology Database (RCOphth NOD).

Methods: Using the in-built audit tool of the electronic medical records system, data from all cataract operations performed between 1 April 2014 and 13 January 2017 were compiled.

Results: Five thousand and eight cases were recorded of which the overall intra-operative complication rate was 2. Read More

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http://dx.doi.org/10.1038/s41433-019-0350-1DOI Listing
February 2019

The use of polyethylene glycol hydrogel tissue adhesive for corneal incision closure following Descemet membrane endothelial keratoplasty (DMEK).

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Baylor College of Medicine, 6501 Fannin, NC-200, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41433-019-0349-7DOI Listing
February 2019

Anterior elongation of the retina in persistent fetal vasculature: emphasis on retinal complications.

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Gazi University School of Medicine, Ankara, 06500, Turkey.

Purpose: To identify the characteristics of peripheral retinal anomalies associated with persistent fetal vasculature (PFV) and evaluate the complications and outcomes.

Methods: Retrospective, noncomparative case series of patients with PFV who underwent surgery. Type of PFV, presence of peripheral retinal anomalies, extent of the retrolental membrane, complications, and functional and anatomical results were evaluated. Read More

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http://dx.doi.org/10.1038/s41433-019-0345-yDOI Listing
February 2019
1 Read

Imaging of meibomian glands: from bench to bedside and back.

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Lid and Meibomian Gland Working Group (LIME), Tokyo, Japan.

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http://dx.doi.org/10.1038/s41433-019-0351-0DOI Listing
February 2019

Randomised trial of wide-field guided PRP for diabetic macular oedema treated with ranibizumab.

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Moorfields Eye Hospital NHS Foundation Trust, London, EC1, UK.

Background: Diabetic macular oedema (DMO) is effectively treated with ranibizumab but multiple injections are required. Where there is also peripheral ischaemia, it has been promoted that targeted panretinal photocoagulation (PRP) may reduce the number of injections.

Method: Patients with optical coherence tomography confirmed DMO and Ultra-widefield Fundus Fluorescein Angiography confirmed peripheral retinal ischaemia were randomised to PRP plus ranibizumab or ranibizumab monotherapy. Read More

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http://dx.doi.org/10.1038/s41433-019-0342-1DOI Listing
February 2019

Ophthalmology specialist trainee survey in the United Kingdom.

Eye (Lond) 2019 Feb 1. Epub 2019 Feb 1.

The Royal College of Ophthalmologists, London, UK.

Background: Currently there are a total of 780 post-graduate ophthalmology trainees in the United Kingdom (UK). Post-graduate ophthalmology training in the UK is 7 years in duration, and follows a comprehensive competency-based curriculum. Changes to training have been proposed as part of the government's Shape of Training paper. Read More

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http://dx.doi.org/10.1038/s41433-019-0344-zDOI Listing
February 2019

Medial canthoplasty for the management of exposure keratopathy.

Eye (Lond) 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Purpose: To report the surgical technique and functional outcomes of the medial canthoplasty for the treatment of exposure keratopathy.

Patients/methods: An IRB approved, retrospective review of patients who underwent medial canthoplasty for exposure keratopathy was performed. Patient demographics, reported symptoms, and clinical examination findings were collected and analyzed from pre-operative and follow-up visits. Read More

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http://www.nature.com/articles/s41433-019-0347-9
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http://dx.doi.org/10.1038/s41433-019-0347-9DOI Listing
February 2019
2 Reads

Correction: How do paper and electronic records compare for completeness? A three centre study.

Eye (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Following the publication of the above article the authors noted an error in the author list, 2 authors were mistakenly omitted. Zena Rodrigues and Faisal Ahmed have now been added to the author list and the PDF and HTML versions of the paper have been corrected. Read More

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http://dx.doi.org/10.1038/s41433-019-0335-0DOI Listing
January 2019

Multimodal imaging of late-onset retinal degeneration complicated by bilateral choroidal neovascularization.

Eye (Lond) 2019 Jan 28. Epub 2019 Jan 28.

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

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http://dx.doi.org/10.1038/s41433-019-0348-8DOI Listing
January 2019

Visual loss secondary to fludarabine toxicity: optical coherence tomography findings in two patients.

Eye (Lond) 2019 Jan 28. Epub 2019 Jan 28.

Medical Eye Unit, St Thomas' Hospital, London, SE1 7EH, UK.

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http://dx.doi.org/10.1038/s41433-019-0343-0DOI Listing
January 2019

Unraveling the role of genetics in the pathogenesis of diabetic retinopathy.

Eye (Lond) 2019 Jan 24. Epub 2019 Jan 24.

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, 30912, Georgia.

Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). Read More

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http://dx.doi.org/10.1038/s41433-019-0337-yDOI Listing
January 2019
1.897 Impact Factor

Risk assessment of sudden visual loss following non-penetrating deep sclerectomy in severe and end-stage glaucoma.

Eye (Lond) 2019 Jan 24. Epub 2019 Jan 24.

Centre Hospitalier National d'Ophtalmologie des 15/20, Service du Pr. NORDMANN, Paris, France.

Background/objectives: To assess the risk of immediate sudden visual loss ("wipe-out" phenomenon) following non-penetrating deep sclerectomy (NPDS) for end-stages glaucoma within the first 6-months postoperative period.

Subjects/methods: Monocenter database study. We reviewed the results for 73 eyes with severe or end-stage glaucoma that underwent NPDS. Read More

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http://dx.doi.org/10.1038/s41433-019-0336-zDOI Listing
January 2019

Changes in macular drusen parameters preceding the development of neovascular age-related macular degeneration.

Eye (Lond) 2019 Jan 24. Epub 2019 Jan 24.

NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Purpose: To assess the rate of change in macular drusen load in fellow eyes of patients with unilateral neovascular age-related macular degeneration (AMD) to evaluate whether the change in drusen load determines the onset and type of choroidal neovascularisation (CNV).

Methods: Subjects with unilateral neovascular AMD with a minimum of 2 years follow-up were identified retrospectively from the hospital electronic database. Drusen count, area and volume measurements at the macula of the contralateral eye were recorded using the commercial software on the Topcon 3D OCT-2000 devices over the previous 2 years. Read More

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http://dx.doi.org/10.1038/s41433-019-0338-xDOI Listing
January 2019

Clinical pathophysiology of thyroid eye disease: The Cone Model.

Eye (Lond) 2019 Feb 18;33(2):244-253. Epub 2019 Jan 18.

Trainee Ophthalmologist, Bristol Eye Hospital, Bristol, UK.

The clinical features of thyroid eye disease are dictated by the orbit's compartmentalisation; particularly, the muscle cone, which is delimited by the rectus muscles, their inter-muscular septa and the posterior sclera. The cone is anchored to the orbit apex and contains the posterior globe, the muscle bellies, a fat pad, and the blood circulation, optic nerve, and CSF sheath. It is surrounded by mobile extraconal fat, retained by the orbital septum. Read More

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http://www.nature.com/articles/s41433-018-0302-1
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http://dx.doi.org/10.1038/s41433-018-0302-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367424PMC
February 2019
9 Reads

Smartphone adaptor use for nasal endoscopy.

Eye (Lond) 2019 Jan 16. Epub 2019 Jan 16.

Department of Ophthalmology, Royal Shrewsbury Hospital, Mytton Oak Road, SY3 8XQ, Shrewsbury, UK.

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http://www.nature.com/articles/s41433-018-0334-6
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http://dx.doi.org/10.1038/s41433-018-0334-6DOI Listing
January 2019
2 Reads

Estimate of incidence of ROP requiring treatment in extreme preterms and impact on service-7 year review in tertiary unit.

Eye (Lond) 2019 Jan 16. Epub 2019 Jan 16.

Bristol Eye Hospital, Bristol, UK.

Background/objectives: Retinopathy of prematurity (ROP) is a potentially blinding disorder affecting premature infants. Our Eye Unit supports two neonatal intensive care units (NICUs), one provides neonatal surgical and medical facilities and the other is exclusively medical. Our objectives were to (1) to identify the annual rate of ROP treatments during the period 2009-2015 and (2) to estimate the incidence of ROP treatment in babies born very prematurely (<27 weeks). Read More

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http://dx.doi.org/10.1038/s41433-018-0330-xDOI Listing
January 2019

Prognostic prediction models for diabetic retinopathy progression: a systematic review.

Eye (Lond) 2019 Jan 16. Epub 2019 Jan 16.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

With the increasing incidence of diabetic retinopathy and its improved detection, there is increased demand for diabetic retinopathy treatment services. Prognostic prediction models have been used to optimise services but these were intended for early detection of sight-threatening retinopathy and are mostly used in diabetic retinopathy screening services. We wanted to look into the predictive ability and applicability of the existing models for the higher-risk patients referred into hospitals. Read More

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http://dx.doi.org/10.1038/s41433-018-0322-xDOI Listing
January 2019
1 Read

Smartphone-based application improves the detection of retinoblastoma.

Eye (Lond) 2019 Jan 11. Epub 2019 Jan 11.

Department of Orbit, Oculoplasty and Oncology, Aravind Eye Hospital, Madurai, India.

Purpose: To improve and validate the smartphone-based leukocoria detection application so that non-ophthalmologists could make use of the smartphone for early detection of Retinoblastoma (RB) in young children without anesthesia and pharmacological dilatation of the pupil.

Methods: Two apps, MDEyeCare and CRADLE, developed for red reflex based leukocoria detection were used in iPhone 6s. MDEyeCare methodology was modified with respect to ambient lighting, the distance between camera and eye and different gazes for better performance. Read More

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http://www.nature.com/articles/s41433-018-0333-7
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http://dx.doi.org/10.1038/s41433-018-0333-7DOI Listing
January 2019
12 Reads

Non-physician grader reliability in measuring morphological features of the optic nerve head in stereo digital images.

Eye (Lond) 2019 Jan 11. Epub 2019 Jan 11.

Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Objective: To introduce a new method of grading optic nerve stereo disc photographs and evaluate reproducibility of assessments by non-physician graders in a reading center.

Methods: Three non-physician graders, experienced in grading features of the retina but not the optic nerve head (ONH), were trained by glaucoma specialists to assess digital stereo color images of the ONH. These graders assessed a total of 2554 digital stereo disc images from glaucoma cases and controls participating in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study by outlining the optic cup and disc. Read More

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http://www.nature.com/articles/s41433-018-0332-8
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http://dx.doi.org/10.1038/s41433-018-0332-8DOI Listing
January 2019
4 Reads

A renaissance of teleophthalmology through artificial intelligence.

Eye (Lond) 2019 Jan 8. Epub 2019 Jan 8.

Associated Retinal Consultants, Neuroscience Center Building, 3555 W 13 Mile Road, Suite LL-20, Royal Oak, MI, 48073, USA.

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http://www.nature.com/articles/s41433-018-0324-8
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http://dx.doi.org/10.1038/s41433-018-0324-8DOI Listing
January 2019
1 Read

Cytomegalovirus infection is not a major cause of corneal graft failure in the United Kingdom.

Eye (Lond) 2019 Jan 8. Epub 2019 Jan 8.

External Disease Service, Moorfields Eye Hospital, London, United Kingdom.

Background: Cytomegalovirus (CMV) endotheliitis is a significant cause for acute corneal allograft rejection in East Asian populations, where there is a high CMV seroprevalence. To determine how frequently CMV is associated with corneal graft failure in the UK, we looked for the presence of CMV DNA in grafts that had failed and had been removed at repeat keratoplasty. We also looked for CMV DNA in corneal rims discarded after corneal transplantation. Read More

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http://dx.doi.org/10.1038/s41433-018-0331-9DOI Listing
January 2019
2 Reads

Ocular abnormalities and complications in anterior megalophthalmos: a case series.

Eye (Lond) 2019 Jan 7. Epub 2019 Jan 7.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Objectives: To describe the clinical and Scheimpflug imaging features in cases of anterior megalophthalmos (AM).

Methods: Retrospective record review was performed for patients with AM who presented between June 2017 and May 2018. Clinical history, slit lamp examination, Scheimpflug imaging indices (Pentacam-HR, Oculus, GmbH), dilated fundus examination and treatment records were reviewed. Read More

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http://dx.doi.org/10.1038/s41433-018-0329-3DOI Listing
January 2019
1 Read

Royal College of Ophthalmologists: National Survey of ST1 Supervision.

Eye (Lond) 2019 Jan 7. Epub 2019 Jan 7.

Buckinghamshire Healthcare NHS Foundation Trust, Aylesbury, UK.

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http://dx.doi.org/10.1038/s41433-018-0325-7DOI Listing
January 2019

Trainee confidence managing ocular trauma.

Eye (Lond) 2019 Jan 7. Epub 2019 Jan 7.

Ophthalmology, Singleton Hospital, Swansea, UK.

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http://dx.doi.org/10.1038/s41433-018-0328-4DOI Listing
January 2019

Effectiveness and safety of accelerated (9 mW/cm) corneal collagen cross-linking for progressive keratoconus: a 24-month follow-up.

Eye (Lond) 2019 Jan 4. Epub 2019 Jan 4.

Sunderland Eye Infirmary, Queen Alexandra Road, Sunderland, SR2 9HP, UK.

Objectives: To examine the effectiveness and safety of accelerated corneal collagen cross-linking (CXL) for keratoconus over a 24-month period and to explore potential prognostic factors for post-treatment visual outcome and progression.

Methods: A retrospective, non-comparative, interventional case series. All patients who underwent accelerated epithelium-off CXL, using 9 mW/cm ultraviolet-A irradiation for 10 min, for progressive keratoconus in Sunderland Eye Infirmary, UK, between May 2014 and July 2016 were included. Read More

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http://dx.doi.org/10.1038/s41433-018-0323-9DOI Listing
January 2019
1 Read

Interruption of autoimmunity for thyroid eye disease: B-cell and T-cell strategy.

Eye (Lond) 2019 Feb 4;33(2):191-199. Epub 2019 Jan 4.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Italy.

Recent new insights into the molecular basis of thyroid eye disease have led to the use of more specific therapies such as monoclonal antibodies This review explores the traditional immunosuppressant therapy for TED, highlighting the basis for emergent recent medications, possible treatment options and, eventually possible new general recommendation for management of TED. Data has been retrieved from the literature searching on Pubmed. Steroid therapy remains the first line therapy for moderate/severe and severe vision threatening TED The use of some traditional nonspecific immunosuppressant such as mycophenolate, cyclosporine and azathioprine seems useful in combination with steroid therapy to achieve stable results in the long term; methotrexate is useful as steroid-sparing medications and in steroid resistant or intolerant patients. Read More

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http://www.nature.com/articles/s41433-018-0315-9
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http://dx.doi.org/10.1038/s41433-018-0315-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367473PMC
February 2019
3 Reads

Short-duration multiple-session subthreshold micropulse yellow laser (577 nm) for chronic central serous chorioretinopathy: results at 3 years.

Eye (Lond) 2019 Jan 4. Epub 2019 Jan 4.

Retina Center, Nune Eye Hospital, Daegu, Republic of Korea.

Objectives: To review the 3-year follow-up results of subthreshold micropulse yellow laser (SMYL) delivered by a short-duration multiple-session method for treatment of chronic central serous chorioretinopathy (CSC).

Methods: A total of 27 eyes from 27 patients with chronic CSC available for 3 years of follow-up were enrolled in this retrospective and interventional study. Patients were treated with 577-nm SMYL photocoagulation at a 15% duty cycle over multiple sessions, with low power ranging from 200 to 400 mW that was increased in 100 mW increments according to resolution of subretinal fluid at monthly follow-up. Read More

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http://dx.doi.org/10.1038/s41433-018-0309-7DOI Listing
January 2019

Influence of peripheral corneal relaxing incisions during cataract surgery for corneal astigmatism up to 2.5 dioptres on corneal densitometry.

Eye (Lond) 2019 Jan 2. Epub 2019 Jan 2.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton, BN2 5BF, UK.

Purpose: To assess the effect of peripheral corneal relaxing incisions (PCRI) for astigmatism between 0.75 and 2.5 dioptres during cataract surgery on corneal densitometry (CD). Read More

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http://dx.doi.org/10.1038/s41433-018-0327-5DOI Listing
January 2019

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom.

Eye (Lond) 2019 Feb 28;33(2):283-294. Epub 2018 Dec 28.

School of Clinical Sciences, University of Edinburgh, Edinburgh, UK.

Purpose: To describe the incidence, associations and outcomes of ocular surface squamous neoplasia (OSSN) in the United Kingdom.

Methods: Prospective, observational study of every new case of OSSN reported via the British Ophthalmological Surveillance Unit reporting scheme over a 12-month period. Cases were followed up for 12 months. Read More

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http://www.nature.com/articles/s41433-018-0217-x
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http://dx.doi.org/10.1038/s41433-018-0217-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367470PMC
February 2019
5 Reads

Teprotumumab, an insulin-like growth factor-1 receptor antagonist antibody, in the treatment of active thyroid eye disease: a focus on proptosis.

Eye (Lond) 2019 Feb 21;33(2):183-190. Epub 2018 Dec 21.

Cedars Sinai Medical Center Los Angeles and Zhongshen Ophthalmic Center, Guangzhou, China.

Thyroid eye disease is a disabling autoimmune disease associated with orbital inflammation and tissue remodeling which can result in significant proptosis, leading to visual alterations and is potentially sight threatening. Current evidence indicates that autoantibodies to the insulin-like growth factor 1 receptor (IGF-1R), along with the thyroid-stimulating hormone receptor (TSHR), mediate the pathogenesis in susceptible individuals. Teprotumumab, a monoclonal IGF-1R antagonist, has demonstrated previously in a 24 week, randomized, controlled trial to produce significant changes in composite outcomes of proptosis and clinical activity score as compared with placebo. Read More

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http://www.nature.com/articles/s41433-018-0321-y
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http://dx.doi.org/10.1038/s41433-018-0321-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367366PMC
February 2019
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Cambridge Ophthalmological Symposium 2018: introduction and reflections on the day.

Authors:
Marian Ludgate

Eye (Lond) 2019 Feb 19;33(2):169-173. Epub 2018 Dec 19.

Professor Emerita, Institute of Infection & Immunity, School of Medicine, Cardiff, UK.

I was privileged to be one of the co-chairs, along with Professor Tim Sullivan (Brisbane, Australia), for the Cambridge Ophthalmological Society (COS) annual international symposium, which, this year, was dedicated to thyroid eye disease (TED). Together with the organisers, Miss Rachna Murthy and Professor Keith Martin from COS, we compiled an impressive programme covering all aspects of the condition from events happening in a single orbital cell to improved surgical approaches. Read More

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http://dx.doi.org/10.1038/s41433-018-0320-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367334PMC
February 2019

YKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome.

Eye (Lond) 2018 Dec 18. Epub 2018 Dec 18.

Bahcesehir University, School of Medicine, Department of Medical Ethics and History of Medicine, Istanbul, Turkey.

Purpose: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX).

Methods: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). Read More

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http://www.nature.com/articles/s41433-018-0308-8
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http://dx.doi.org/10.1038/s41433-018-0308-8DOI Listing
December 2018
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Prospective analysis of the predictors of glaucoma following surgery for congenital and infantile cataract.

Eye (Lond) 2018 Dec 18. Epub 2018 Dec 18.

Department of Glaucoma, Sri Jadhavbhai Nathmal Singhvi, Sankara Nethralaya, New No: 41, old no: 18 College Road, Nungambakkam, Chennai, 600006, Tamil Nadu, India.

Purpose: A prospective longitudinal cohort study was performed to assess the incidence of and risk factors for the development of glaucoma following surgery for congenital/infantile cataract.

Methods: One hundred and one eyes of one hundred and one children, ≤12 years of age who had follow-up of ≥24 months were included. Group I included those who underwent surgery using an anterior approach, group II included those who underwent surgery using a posterior approach, and group III included those who underwent surgery using an anterior approach along with foldable intraocular lens implantation. Read More

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http://www.nature.com/articles/s41433-018-0316-8
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http://dx.doi.org/10.1038/s41433-018-0316-8DOI Listing
December 2018
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