4,554 results match your criteria Extrinsic Allergic Alveolitis

[Girl with hypersensitivity pneumonitis. A case report].

Rev Alerg Mex 2021 Jan-Mar;68(1):84-88

Hospital Universitario La Paz, Servicio de Alergología, Madrid, España.

Background: Hypersensitivity pneumonitis entails several inflammatory lung diseases that preferentially affect the alveolar and perialveolar tissue. It is a very rare disease in children, with a complicated diagnosis due to the fact that antigen exposure usually goes unnoticed.

Case Report: A 12-year-old girl with dry cough, dyspnea, wheezing, and tachypnea, with partial improvement after treatment with inhaled bronchodilators and corticoids. Read More

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Hypersensitivity Pneumonitis in a Pediatric Patient.

J Coll Physicians Surg Pak 2021 Jun;30(6):735-736

Department of Pediatric Medicine, Nishtar Medical University, Multan, Pakistan.

Hypersensitivity pneumonitis (HP) is a rarely diagnosed interstitial lung disease with variable manifestations. It results from repeated inhalation of certain antigens, e.g. Read More

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[Interstitial lung disease revisited].

H D Jiang B Chen

Zhonghua Yi Xue Za Zhi 2021 Jun;101(20):1453-1457

Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China.

Interstitial lung disease (ILD), consisting of more than 200 subtypes of diseases, is a large group of heterogeneous diseases characterized by varying degrees of alveolitis and pulmonary parenchymal fibrosis. There are many challenges in its diagnosis and treatment. In recent years, new understanding of the clinical classification, disease behavior, early diagnosis, and treatment of ILD has been obtained. Read More

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Management of Fibrotic Hypersensitivity Pneumonitis.

Clin Chest Med 2021 Jun;42(2):311-319

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

Fibrotic hypersensitivity pneumonitis (fHP) is a chronic, often progressive fibrosing form of interstitial lung disease caused by inhaled antigenic exposures. fHP can lead to impaired respiratory function, reduced disease-related quality of life, and early mortality. Management of fHP should start with exposure remediation where possible, with systemic immunosuppression and antifibrotic therapy considered in patients with symptomatic or progressive disease. Read More

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Exposures and associations with clinical phenotypes in hypersensitivity pneumonitis: A scoping review.

Respir Med 2021 Aug 6;184:106444. Epub 2021 May 6.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: https://twitter.com/KerriBerriKerri.

Antigen identification is important for establishing a confident diagnosis of hypersensitivity pneumonitis (HP). There are no systematically curated lists of HP-associated exposures that inform clinical relevance or disease phenotype. We sought to systematically identify all reported causes of HP in the literature and evaluate their clinical relevance. Read More

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[Hypersensitivity Pneumonitis: An update].

Rev Med Interne 2021 Apr 30. Epub 2021 Apr 30.

Service de Médecine Interne et Immunologie Clinique, Hôpital Pontchaillou, Rennes, France; Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, Rennes, France. Electronic address:

Hypersensitivity Pneumonitis (HP) is a common immune-mediated interstitial lung disease (ILD) induced by repeated exposure to environmental antigens in susceptible individuals. The most commonly known forms are bird fancier's disease and farmer's lung. However, the antigens involved are widely diverse. Read More

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Performance of a diagnostic algorithm for fibrotic hypersensitivity pneumonitis. A case-control study.

Respir Res 2021 Apr 23;22(1):120. Epub 2021 Apr 23.

Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.

Background: The differential diagnosis fibrotic hypersensitivity pneumonitis (HP) versus idiopathic pulmonary fibrosis (IPF) is important but challenging. Recent diagnostic guidelines for HP emphasize including multidisciplinary discussion (MDD) in the diagnostic process, however MDD is not comprehensively available. We aimed to establish the diagnostic accuracy and prognostic validity of a previously proposed HP diagnostic algorithm that foregoes MDD. Read More

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Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study.

Lancet Respir Med 2021 Apr 1. Epub 2021 Apr 1.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Previous studies suggested that the prevalence of chronic respiratory disease in patients hospitalised with COVID-19 was lower than its prevalence in the general population. The aim of this study was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affects the risk of contracting severe COVID-19.

Methods: In this population cohort study, records from 1205 general practices in England that contribute to the QResearch database were linked to Public Health England's database of SARS-CoV-2 testing and English hospital admissions, intensive care unit (ICU) admissions, and deaths for COVID-19. Read More

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Case report of amiodarone-associated allergic pneumonitis amidst the COVID-19 pandemic.

Rev Cardiovasc Med 2021 03;22(1):181-184

Department of Cardiology, Epworth Healthcare, Melbourne, 3121 Victoria, Australia.

Amiodarone is a common antiarrhythmic drug that is utilised in clinical practice and is associated with pulmonary toxicity. The most common form of pulmonary complication is interstitial pneumonitis which is treated with discontinuation of amiodarone and initiation of corticosteroids. Amiodarone-induced pulmonary eosinophilia is a rare complication of amiodarone therapy, with blood and pulmonary eosinophilia the predominant features. Read More

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Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection.

Mil Med Res 2021 03 9;8(1):19. Epub 2021 Mar 9.

Department of Dermatology, The Seventh Medical Center of PLA General Hospital, 5 Nanmencang, Dongcheng District, Beijing, 100700, China.

Background: Invasive Trichosporon asahii (T. asahii) infection frequently occurs with a high mortality in immunodeficient hosts, but the pathogenesis of T. asahii infection remains elusive. Read More

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Waterproofing spray-associated pneumonitis review: Comparison with acute eosinophilic pneumonia and hypersensitivity pneumonitis.

Medicine (Baltimore) 2021 Mar;100(10):e25054

Respiratory Disease Center, Fukujuji Hospital, Japan Anti-tuberculosis Association, Kiyose City, Tokyo, Japan.

Abstract: Waterproofing spray-associated pneumonitis (WAP) proceeds to acute respiratory failure and is characterized by diffuse bilateral ground-glass opacities on computed tomography; however, the detailed characteristics of WAP are unknown. Therefore, this study identified the characteristics of WAP from comparisons with those of acute eosinophilic pneumonia (AEP) and hypersensitivity pneumonitis (HP), which show similar features to WAP.Adult patients with WAP, AEP, and HP treated in Fukujuji Hospital from 1990 to 2018 were retrospectively enrolled. Read More

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Arerugi 2021 ;70(2):127-131

Department of Respiratory Medicine, Tokyo Medical and Dental University.

A 52-year-old woman presented to a clinic in late August with exacerbated fatigue and dyspnea on exertion for several months. Then, she was referred and admitted to our hospital in late September. Her chest CT showed bilateral diffuse centrilobular micronodules. Read More

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Implication of efflux pumps and genes in resistance of clinical isolates to fluconazole.

J Med Microbiol 2021 Mar 10;70(3). Epub 2021 Mar 10.

Fungal and Parasitic Molecular Biology Laboratory, School of Medicine, University of Sfax, Sfax, Tunisia.

has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Molecular mechanisms of azole resistance have been rarely reported for . Similar to other fungi, we hypothesized that both gene mutation and efflux pumps genes hyper-expression were implicated. Read More

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Carbohydrate antigen 15-3 as a marker of disease severity in patients with chronic hypersensitivity pneumonitis.

J Bras Pneumol 2021 8;47(1):e20200589. Epub 2021 Mar 8.

. Disciplina de Pneumologia, Universidade Federal de São Paulo - UNIFESP - São Paulo (SP) Brasil.

Objective: Biomarkers associated with mucin 1, such as Krebs von den Lungen-6 and carbohydrate antigen (CA) 15-3, are increased in various interstitial lung diseases. Our aim was to determine whether CA 15-3 could be considered a biomarker of disease severity in patients with chronic hypersensitivity pneumonitis (cHP).

Methods: This was a prospective observational study involving adult patients with cHP. Read More

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[Hypersensitivity pneumonia diagnosed by excisional lung biopsy: a clinicopathological features of 47 cases].

Zhonghua Bing Li Xue Za Zhi 2021 Mar;50(3):222-228

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To analyze the clinicopathological and immunohistochemical characteristics of the hypersensitivity pneumonia (HP) cases that were diagnosed by excisional lung biopsy, to improve the diagnosis accuracy of HP. The data of 47 HP cases diagnosed by excisional lung biopsy during the last 20 years were collected in Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, from January 2000 to June 2020. The clinicopathological features and the immunohistochemical profiles of CD3, CD4, CD8 and CD20 were analyzed using light microscopy and immunohistochemical stains. Read More

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High-resolution CT in smoking-related interstitial lung diseases.

Int J Tuberc Lung Dis 2021 02;25(2):106-112

Diagnostica per Immagini, Ospedale San Giuseppe, IRCCS Multimedica, Milan, Italy.

In addition to chronic obstructive pulmonary disease (COPD) and bronchogenic carcinoma, smoking can also cause interstitial lung diseases (ILDs) such as respiratory bronchiolitis (RB), RB with ILD (RB-ILD), desquamative interstitial pneumonia (DIP), Langerhans cell granulomatosis (LCG) and idiopathic pulmonary fibrosis-usual interstitial pneumonia (IPF-UIP). However, smoking seems to have a protective effect against hypersensitivity pneumonitis (HP), sarcoidosis and organising pneumonia (OP). High-resolution computed tomography (HRCT) has a pivotal role in the differential diagnosis. Read More

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February 2021

Micronodular pattern organising pneumonia mimicking miliary lung disease: a rare radiological presentation.

BMJ Case Rep 2021 Feb 23;14(2). Epub 2021 Feb 23.

Department of Diagnostic Imaging, Monash Health, Clayton, Victoria, Australia.

Organising pneumonia (OP) is an interstitial lung disease characterised by granulation tissues in alveoli and alveolar ducts. Typical imaging findings are migratory airspace opacities with peripheral or peribronchovascular distribution. Diffuse micronodular OP (MNOP) is a rare imaging manifestation, which has imaging differential diagnosis of endobronchial infection such as tuberculosis, hypersensitivity pneumonitis and respiratory bronchiolitis. Read More

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February 2021

Antigen avoidance in people with hypersensitivity pneumonitis: A scoping review.

Heart Lung 2021 May-Jun;50(3):407-416. Epub 2021 Feb 20.

Department of Critical and Invasive-Palliative Care Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:

Background: Antigen avoidance (AA) is essential for people with hypersensitivity pneumonitis (HP). An intervention programme to promote continuous AA in people with HP will be the focus of future research.

Objectives: We systematically analysed the AA behaviour of people with HP, interventions of health-care providers to promote AA behaviour, clinical outcomes after AA, and evaluation methods after AA. Read More

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Insights on chronic hypersensitivity pneumonitis' treatment: Factors associated with a favourable response to azathioprine.

Life Sci 2021 May 20;272:119274. Epub 2021 Feb 20.

Faculty of Medicine, University of Porto, Porto, Portugal; Institute for Research and Innovation in Health, University of Porto, Porto, Portugal; Pneumology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.

Background: The use of immunosuppressive and antifibrotic agents for the treatment of chronic hypersensitivity pneumonitis (CHP) appears promising, but there is still no evidence supporting the clinical decision regarding the implementation of each specific pharmacological strategy.

Methods: Patients diagnosed with CHP and treated with azathioprine (AZA) were retrospectively selected from a single centre for Interstitial Lung Diseases. Baseline clinical data, as well as functional, imaging, bronchoalveolar lavage (BAL) and histology features were assessed. Read More

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Unusual complications of bone wax at the skull base.

J Laryngol Otol 2021 Mar 17;135(3):217-223. Epub 2021 Feb 17.

Department of ENT, Christian Medical College, Vellore, India.

Objective: This study aimed to describe the clinical presentation, microbiological profile and management of complications of bone wax usage for surgical procedures at the skull base.

Method: The case records of a series of five patients who developed post-operative surgical site complications because of bone wax usage during skull base surgery were reviewed.

Results: In all five patients, persistent site-specific clinical features were noted along with intra-operative presence of excessive bone wax. Read More

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Sooty bark disease of maples: the risk for hypersensitivity pneumonitis by fungal spores not only for woodman.

J Occup Med Toxicol 2021 Jan 21;16(1). Epub 2021 Jan 21.

Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany.

In the middle of the twentieth century, the from North America sooty bark disease (SBD) of maples was first discovered in England and has spread in the last decades in Central Europe, in particular. The trigger of SBD is the mould fungus Cryptostroma (C.) corticale. Read More

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January 2021

[Bird fancier's disease in a child: about a rare and unusual case].

Pan Afr Med J 2020 29;37:189. Epub 2020 Oct 29.

Unité de Pneumopédiatrie, Service de Pédiatrie A, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Marrakech, Maroc.

Bird fancier's disease falls within the spectrum of hypersensitivity pneumonitis secondary to immuno-allergic reaction to avian antigens. This occurs only rarely in children. It is found in two-thirds of patients with hypersensitivity pneumonitis. Read More

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January 2021

Tobacco Worker's Lung: A Neglected Subtype of Hypersensitivity Pneumonitis.

Lung 2021 02 11;199(1):13-19. Epub 2021 Jan 11.

Division of Respirology, Western University, London, ON, Canada.

Tobacco worker's lung (TWL) is a type of hypersensitivity pneumonitis (HP) affecting workers exposed to tobacco leaves and molds in the humidified environment of the tobacco production industry. Limited epidemiological data point to a prevalence of TWL that is not negligible and probably underestimated. As in other types of HP, an acute vs. Read More

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February 2021

Plasma cell-rich bronchoalveolar lavage fluid: Could be a first clue to IgG4 plasma cell-related lung disease.

Diagn Cytopathol 2021 Jul 6;49(7):E253-E257. Epub 2021 Jan 6.

Respiratory Unit, Rashid Hospital, Dubai, United Arab Emirates.

Plasma cells are usually absent in normal bronchoalveolar lavage (BAL) fluids. Frequent plasma cells in BAL are always pathologically significant. They raise a rather narrow differential diagnosis, predominantly extrinsic allergic alveolitis and few other interstitial lung diseases. Read More

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Rituximab therapy in a patient with steroid-refractory bird fancier's lung.

BMJ Case Rep 2020 Dec 22;13(12). Epub 2020 Dec 22.

Department of Respiratory Medicine, Mater Dei Hospital, L-Imsida, Malta.

A 62-year-old woman presented with a 3-month history of shortness of breath on exertion and dry cough. On examination, she was noted to have fine end-inspiratory crepitations over the upper zone of the lungs. Pulmonary function tests (PFTs) showed a restrictive defect. Read More

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December 2020

COVID 19 - Possible interrelations with respiratory comorbidities caused by occupational exposure to various hazardous bioaerosols. Part I. Occurrence, epidemiology and presumed origin of the pandemic.

Ann Agric Environ Med 2020 Dec 8;27(4):491-504. Epub 2020 Dec 8.

Department of Medical Biology, Institute of Rural Heath, Lublin, Poland.

The occupational bioaerosols containing viruses, bacteria, fungi, microbial toxins and plant or animal particles, may evoke infectious, allergic or immunotoxic diseases which may co-exist as comorbidities with COVID-19 and exacerbate the course of disease. They include hypersensitivity pneumonitis (HP) caused mostly by bacteria, fungi, and particles containing animal proteins, and immunotoxic diseases such as organic dust toxic syndrome (ODTS) and byssinosis, caused mostly by bacterial and fungal toxins. The two most probable scenarios of possible interrelations between these three comorbidities (CM) and COVID-19 are: 1) 'Triggering' - when infection with SARS-CoV-2 triggers severe CM after bioaerosol exposure; 2) 'Reverse triggering' when exposure to bioaerosol exacerbates a symptomless or mild course of COVID-19, and evokes a severe disease. Read More

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December 2020

[Fibrotic hypersensitivity pneumonia: focus on pathology-relevant aspects of the new ATS/JRS/ALAT clinical guideline for the diagnosis of hypersensitivity pneumonia in adults].

Pathologe 2021 Feb 23;42(1):48-54. Epub 2020 Dec 23.

Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Rue du Bugnon 25, 1011, Lausanne, Schweiz.

Hypersensitivity pneumonia (HP), also called exogenous allergic alveolitis, is a chronic interstitial pneumonia induced by a hypersensitivity reaction to an identified or unidentified antigen in exposed and susceptible individuals that may progress to terminal lung fibrosis. The diagnosis of HP presents a diagnostic challenge. Though therapeutically important, it may be particularly difficult to differentiate fibrotic HP, historically termed chronic HP, from idiopathic pulmonary fibrosis (IPF) or interstitial lung disease associated with connective tissue diseases (CTD-ILD). Read More

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February 2021