32,577 results match your criteria Extrinsic Allergic Alveolitis
Dev Biol 2018 Dec 11. Epub 2018 Dec 11.
The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, 4072, Australia. Electronic address:
A neuron's contribution to the information flow within a neural circuit is governed by the structure of its dendritic arbor. The geometry of the dendritic arbor directly determines synaptic density and the size of the receptive field, both of which influence the firing pattern of the neuron. Importantly, the position of individual dendritic branches determines the identity of the neuron's presynaptic partner and thus the nature of the incoming sensory information. Read More
Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Greifswald-Insel Riems, Germany. Electronic address:
The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered the further expansion and the efficient propagation of the zoonotic arthropod-borne West Nile virus in many Southern/Southeastern and even Central European countries. WNV infections were detected for the first time in resident wild and aviary birds, such as common blackbirds, northern goshawks and great grey owls in Eastern and Southeastern Germany. Read More
J Cosmet Dermatol 2018 Dec;17(6):1200-1204
Department of Dermatology & Venereology, Medical School, Zagazig University, Cairo, Egypt.
Skin aging is a complex biological process that arises from two basic processes: intrinsic aging (influenced by genetics factors, cellular metabolism, hormone, and metabolic processes) and extrinsic aging caused by chronic light exposure, pollution, ionizing radiation, chemicals, toxins (Expert Opin Biol Ther. 2008;8:393). Intrinsic aging called also chronological aging is observed in sun-protected skin of elderly persons. Read More
Dev Sci 2018 Dec 13:e12786. Epub 2018 Dec 13.
School of Psychology, University of Surrey, Guilford, Surrey, GU27XH, UK.
Spatial thinking is an important predictor of mathematics. However, existing data do not determine whether all spatial sub-domains are equally important for mathematics outcomes nor whether mathematics-spatial associations vary through development. This study addresses these questions by exploring the developmental relations between mathematics and spatial skills in children aged 6 -10 years (N = 155). Read More
Angew Chem Int Ed Engl 2018 Dec 12. Epub 2018 Dec 12.
Beijing Institute of Technology, Advanced Research Institute of Multidisciplinary Science, 5 Zhongguancun South Street,, Beijing Institute of Technology, 100081, Beijing, CHINA.
Surface reactions constitute the foundation of various energy conversion/storage technologies such as the lithium-sulfur (Li-S) batteries. To expedite surface reactions for high-rate battery applications demands for in-depth understanding of reaction kinetics and rational catalyst design. Herein, we proposed an in-situ extrinsic-metal etching strategy to activate an inert monometal nitride of hexagonal Ni3N through iron-incorporated cubic Ni3FeN. Read More
Radiat Oncol 2018 Dec 14;13(1):245. Epub 2018 Dec 14.
Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background: Oesophageal cancer with airway invasion presents a challenge for therapy and often has serious complications. We analysed the clinical outcomes of radiation therapy (RT) in patients with clinical T4b oesophageal cancer with airway invasion.
Methods: We retrospectively reviewed the medical records of 73 patients with oesophageal cancer who had clinical T4 disease and who received RT between January 1994 and June 2017. Read More
Front Neural Circuits 2018 27;12:103. Epub 2018 Nov 27.
Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
The central complex (CX) is a midline-situated collection of neuropil compartments in the arthropod central brain, implicated in higher-order processes such as goal-directed navigation. Here, we provide a systematic genetic-neuroanatomical analysis of the ellipsoid body (EB), a compartment which represents a major afferent portal of the CX. The neuropil volume of the EB, along with its prominent input compartment, called the bulb, is subdivided into precisely tessellated domains, distinguishable based on intensity of the global marker DN-cadherin. Read More
2018 Apr 14;60(1-2):111-125. Epub 2018 May 14.
School of Aquatic and Fishery Sciences, University of Washington.
A model describes the relationship between mammal body mass and survivorship by combining replicative senescence theory postulating a cellular basis of aging, metabolic theory relating metabolism to body mass, and vitality theory relating survival to vitality loss and extrinsic mortality. In the combined framework, intrinsic mortality results from replicative senescence of the hematopoietic stem cells and extrinsic mortality results from environmental challenges. Because the model expresses the intrinsic and extrinsic rates with different powers of body mass, across the spectrum of mammals, survivorship changes from Type I to Type II curve shapes with decreasing body mass. Read More
Haematologica 2018 Dec 13. Epub 2018 Dec 13.
Columbia University College of Physicians and Surgeons;
Various extrinsic signals tightly control hematopoietic stem cell quiescence. Our recent study showed that hematopoietic stem cells are regulated by a special FoxP3+ regulatory T cell population with high expression of a hematopoietic stem cell marker, CD150. Extracellular adenosine generated via a cell-surface ectoenzyme CD39 on CD150high regulatory T cells maintained HSC quiescence. Read More
Curr Probl Cardiol 2018 Nov 9. Epub 2018 Nov 9.
Clinical trial results provide the critical evidence base for evaluating the safety and efficacy of new medicines and medical products. Efficacy and safety may differ among population subgroups depending on intrinsic/extrinsic factors, including sex, age, race, ethnicity, lifestyle, and genetic background. Racial and ethnic minorities continue to be underrepresented in cardiovascular and other clinical trials. Read More
Med Teach 2018 Dec 13:1-2. Epub 2018 Dec 13.
a Amsterdam UMC, VUmc School of Medical Sciences , Amsterdam , The Netherlands.
Intrinsic motivation was a reining concept for many years in self-determination theory (SDT) research. Since the last 10 years, the concept of autonomous motivation is used more commonly by some researchers. Autonomous motivation means motivation arising out of genuine interest or personal endorsement or valuing of an activity. Read More
Cells 2018 Dec 12;7(12). Epub 2018 Dec 12.
Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy.
Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Read More
Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.
Department of Veterinary Sciences, University of Turin, Grugliasco (TO) I-10095, Italy.
Caspase-3, onto which there is a convergence of the intrinsic and extrinsic apoptotic pathways, is the main executioner of apoptosis. We here review the current literature on the intervention of the protease in the execution of naturally occurring neuronal death (NOND) during cerebellar development. We will consider data on the most common altricial species (rat, mouse and rabbit), as well as humans. Read More
Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.
State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Wuhan 430079, China.
Laser rangefinders (LRFs) are widely used in autonomous systems for indoor positioning and mobile mapping through the simultaneous localization and mapping (SLAM) approach. The extrinsic parameters of multiple LRFs need to be determined, and they are one of the key factors impacting system performance. This study presents an extrinsic calibration method of multiple LRFs that requires neither extra calibration sensors nor special artificial reference landmarks. Read More
J Vet Med Sci 2018 Dec 12. Epub 2018 Dec 12.
Department of Virology, Faculty of Veterinary Medicine, Kirikkale University.
Schmallenberg virus (SBV), discovered in 2011 in Germany, is associated with clinical manifestations of fever, diarrhea, reduced milk yield, abortions and congenital malformations in ruminants. Despite many studies performed for SBV, there is no detailed research on in vitro apoptotic effect of SBV. This study is aimed to determine apoptosis pathways and role of pro-apoptotic and anti-apoptotic molecules in Vero cells infected with SBV. Read More
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):752-754
Qilu Hospital of Shandong University, Jinan 250012, China.
To investigate the relationship between job satisfaction and emotional labor surface performance of nurses in emergency department of Shandong province, and to provide realistic basis for the nursing management to develop targeted improvement measures. The general situation questionnaire and emotional labor scale were used to investigate 276 emergency department nurses in 10 comprehensive hospitals in Shandong province. The internal satisfaction and external satisfaction scores of the nurses in the emergency department were respectively (3. Read More
Front Oncol 2018 14;8:525. Epub 2018 Nov 14.
Programa de Pós-Graduação em Biotecnologia, Grupo de Pesquisa em Oncologia Celular e Molecular, Biotecnologia/Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Brazil.
Triple-negative breast cancer represents about 15% of all cases of breast cancer, and still represents a therapeutic challenge. 3'-Azido-3'-deoxythymidine (AZT) is a nucleoside reverse transcriptase inhibitor with antitumor activity. Chalcogenides compounds, such as selenium, are very important intermediates applied in organic synthesis. Read More
Oncoimmunology 2018 6;7(12):e1500108. Epub 2018 Sep 6.
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, USA.
Immune checkpoint blockade targeting programmed cell death protein 1 (PD-1) is emerging as an important treatment strategy in a growing list of cancers, yet its clinical benefits are limited to a subset of patients. Further investigation of tumor-intrinsic predictors of response and how extrinsic factors, such as iatrogenic immunosuppression caused by conventional therapies, impact the efficacy of anti-PD-1 therapy are paramount. Given the widespread use of corticosteroids in cancer management and their immunosuppressive nature, this study sought to determine how corticosteroids influence anti-PD-1 responses and whether their effects were dependent on tumor location within the periphery versus central nervous system (CNS), which may have a more limiting immune environment. Read More
Front Neurol 2018 20;9:946. Epub 2018 Nov 20.
John van Geest Center for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
The immune system is activated in Parkinson's Disease (PD), as evidenced by neuroinflammatory changes within the brain as well as elevated immune markers in peripheral blood. Furthermore, inflammatory cytokine levels in the blood are associated with disease severity and rate of progression. However, the factors driving this immune response in PD are not well established. Read More
Mediators Inflamm 2018 4;2018:4310419. Epub 2018 Nov 4.
Department of Neonatology, University Children's Hospital, Aachen, Germany.
Neonates are highly susceptible to microbial infections which is partially attributable to fundamental phenotypic and functional differences between effector cells of the adult and neonatal immune system. The resolution of the inflammation is essential to return to tissue homeostasis, but given that various neonatal diseases, such as periventricular leukomalacia, necrotizing enterocolitis, or bronchopulmonary dysplasia, are characterized by sustained inflammation, newborns seem predisposed to a dysregulation of the inflammatory response. Targeted apoptosis of effector cells is generally known to control the length and extent of the inflammation, and previous studies have demonstrated that phagocytosis-induced cell death (PICD), a special type of apoptosis in phagocytic immune cells, is less frequently triggered in neonatal monocytes than in adult monocytes. Read More
Bull Math Biol 2018 Dec 6. Epub 2018 Dec 6.
Department of Mathematics, University of Utah, Salt Lake City, 84112, USA.
Biochemical reactions are often subject to a complex fluctuating environment, which means that the corresponding reaction rates may themselves be time-varying and stochastic. If the environmental noise is common to a population of downstream processes, then the resulting rate fluctuations will induce statistical correlations between them. In this paper we investigate how such correlations depend on the form of environmental noise by considering a simple birth-death process with dynamical disorder in the birth rate. Read More
Nano Lett 2018 Dec 12. Epub 2018 Dec 12.
Polypeptides are exceptionally promising carriers for chemotherapeutics: they have minimal toxicity, can be recombinantly synthesized with precise control over molecular weight, and enhance drug pharmacokinetics as self-assembled nanoparticles. Polypeptide-based systems also provide the ability to achieve active targeting with genetically encoded targeting ligands. While passive targeting promotes accumulation of nanocarriers in solid tumors, active targeting provides an additional layer of tunable control and widens the therapeutic window. Read More
Soft Matter 2018 Dec 12. Epub 2018 Dec 12.
Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA.
We study the periodic buckling patterns that emerge when elastic shells are subjected to geometric confinement. Residual swelling provides access to range of shapes (saddles, rolled sheets, cylinders, and spherical sections) which vary in their extrinsic and intrinsic curvatures. Our experimental and numerical data show that when these moderately thick structures are radially confined, a single geometric parameter - the ratio of the total shell radius to the amount of unconstrained material - predicts the number of lobes formed. Read More
Sports Med Int Open 2018 Jun 17;2(3):E62-E66. Epub 2018 Jun 17.
Miami University, Kinesiology and Health, Oxford, United States.
Motives for physical activity were compared between adults who either successfully or unsuccessfully maintained regular physical activity over the last 10 years. Adults age 28-45 (N=721) completed an online survey, reporting their current physical activity levels and self-determination theory (SDT) motives, as well as their physical activity levels at least 10 years prior. With participants' current and retrospective reports of their physical activity, four sample subgroups were created, including maintainers, improvers, decliners, and sedentary. Read More
Nat Commun 2018 12 11;9(1):5279. Epub 2018 Dec 11.
Regeneration in Hematopoiesis and Animal Models in Hematopoiesis, Institute for Immunology, Fetscherstr. 74, 01307, Dresden, Germany.
Regulatory mechanisms controlling the pool size of spleen dendritic cells (DC) remain incompletely understood. DCs are continuously replenished from hematopoietic stem cells, and FLT3-mediated signals cell-intrinsically regulate homeostatic expansion of spleen DCs. Here we show that combining FLT3 and CSF1R-deficiencies results in specific and complete abrogation of spleen DCs in vivo. Read More
J Cardiol Cases 2013 Mar 1;7(3):e71-e73. Epub 2013 Feb 1.
Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 80, Guro-2-dong, Guro-gu, Seoul 152 703, Korea.
Oculopharyngeal muscular dystrophy (OPMD) is an uncommon autosomal dominant disorder that has been characterized by slow progression. Neuromuscular disease is one of several etiologies of pulmonary volume restriction from extrinsic or parenchymatous causes and can lead to pulmonary hypertension and right-sided heart failure, which is consistent with cor pulmonale. Here we describe a case of an OPMD patient with cor pulmonale that was reversed using mechanically-assisted ventilation. Read More
J Cardiol Cases 2013 Mar 29;7(3):e61-e63. Epub 2013 Jan 29.
Cardiology Department, Hospital General Universitario "Gregorio Marañón", c/Dr. Esquerdo, 46, 28007 Madrid, Spain.
We report the case of a 51-year-old woman who presented with acute myocardial infarction as initial symptom of an infiltrative lung neoplasia. The patient was admitted to our center following an out-of-hospital cardiac arrest due to ventricular fibrillation which was cardioverted. On electrocardiography an anterior wall ST-elevation was found and urgent coronary angiography was performed. Read More
J Cardiol Cases 2010 Dec 3;2(3):e154-e158. Epub 2010 Aug 3.
Department of Cardiology, Cardiovascular Center, Tsuchiya General Hospital, 3-30 Nakajimacho Nakaku, Hiroshima City 730-8655, Japan.
Stenosis of the left main coronary artery (LMCA) due to extrinsic compression, producing symptoms of myocardial ischemia, is called left main compression syndrome. We report on a 43-year-old male with acute coronary syndrome who developed left main compression syndrome while waiting for a lung transplantation secondary to interstitial pneumonia, but underwent successful LMCA stenting as emergent treatment. Coronary angiography 3 months after the operation showed good stent patency in the LMCA, and the clinical course was favorable. Read More
J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.
Department for Small Animals, Critical Care Unit, University of Zurich, Zurich, Switzerland.
Background: Correlation of plasma fibrinogen concentration (fibrinogen ) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs.
Objectives: To determine the correlation between plasma coagulation tests and fibrinogen with ROTEM parameters and to evaluate their ability to predict bleeding in dogs.
Animals: Ninety-seven dogs with concurrent determination of fibrinogen and fibrin polymerization test (FIBTEM) analysis. Read More
Evolution 2018 Dec 11. Epub 2018 Dec 11.
Division of Ecology and Evolution, Research School of Biology, The Australian National University, 0200, Canberra, ACT, Australia.
Testing hypotheses on the drivers of clade evolution and trait diversification provides insight into many aspects of evolutionary biology. Often, studies investigate only the intrinsic biological properties of organisms as the causes of diversity, however extrinsic properties of a clade's environment, particularly geological history, may also offer compelling explanations. The Andes are a young mountain chain known to have shaped many aspects of climate and diversity of South America. Read More
Head Neck 2018 Dec 11. Epub 2018 Dec 11.
Department of Otorhinolaryngology, Head and Neck Surgery, University of Brescia, Milan, Italy.
Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread.
Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Read More
J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
New perspectives have been opened by advances in stem cell research for reproductive and regenerative medicine. Several different cell types can be differentiated from stem cells (SCs) under suitable in vitro and in vivo conditions. The differentiation of SCs into male germ cells has been reported by many groups. Read More
Int Arch Occup Environ Health 2018 Dec 7. Epub 2018 Dec 7.
Institute of Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Purpose: The effort-reward imbalance (ERI) model includes extrinsic and intrinsic aspects of work stress. The single components, ERI and overcommitment (OC), are known to be associated with mental health. The aim of this study was to test whether OC is a mediator of the association between ERI and mental health. Read More
Hum Mol Genet 2018 Dec 10. Epub 2018 Dec 10.
Hunter James Kelly Research Institute.
Myelin sheath thickness is precisely regulated and essential for rapid propagation of action potentials along myelinated axons. In the peripheral nervous system, extrinsic signals from the axonal protein neuregulin 1 type III regulate Schwann cell fate and myelination. Here we ask if modulating neuregulin 1 type III levels in neurons would restore myelination in a model of congenital hypomyelinating neuropathy (CHN). Read More
Carcinogenesis 2018 Dec 8. Epub 2018 Dec 8.
Biochemistry Division, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Lucknow, India.
Sphaeranthus indicus Linn. is commonly used in Indian traditional medicine for management of multiple pathological conditions. However, there are limited studies on anti-cancer activity of this plant and its underlying molecular mechanisms. Read More
Int J Sports Phys Ther 2018 Dec;13(6):1083-1094
Background And Purpose: Tendinopathy of the supraspinatus muscle is a frequent cause of shoulder pain. Although it is a common condition, the pathophysiology is not fully understood. The purpose of this clinical commentary is to provide an overview of the pathophysiology of supraspinatus tendinopathy and discuss the conservative treatment solutions. Read More
World J Hepatol 2018 Nov;10(11):887-891
Scripps Center for Organ Transplant, Scripps Green Hospital, La Jolla, CA 92037, United States.
Abdominal pain with elevated transaminases from inferior vena cava (IVC) obstruction is a relatively common reason for referral and further workup by a hepatologist. The differential for the cause of IVC obstruction is extensive, and the most common etiologies include clotting disorders or recent trauma. In some situations the common etiologies have been ruled out, and the underlying process for the patient's symptoms is still not explained. Read More
Inorg Chem 2018 Dec 11. Epub 2018 Dec 11.
Shenyang National Laboratory for Materials Science (SYNL) , Institute of Metal Research (IMR), Chinese Academy of Sciences (CAS) , No. 72 Wenhua Road , Shenyang 110016 , China.
The peculiar physical and chemical properties of 2D nanostructures have aroused global research interest in developing new members, synthetic technology, and exploring their potential applications in functional nanodevices. However, it is extremely challenging to directly obtain the 2D nanosheets for these extrinsic layered structures using conventional routines. In this work, we demonstrate the facile and general synthesis of 2D spinel-type metal oxides nanosheets through a simple hydrothermal reaction. Read More
Sci Rep 2018 Dec 10;8(1):17739. Epub 2018 Dec 10.
Lehrstuhl für Mikrobielle Ökologie, ZIEL - Institute for Food & Health, Wissenschaftszentrum Weihenstephan, Technische Universität München, Weihenstephaner Berg 3, 85354, Freising, Germany.
Small noncoding RNAs (sRNAs) with putative regulatory functions in gene expression have been identified in the enteropathogen Salmonella enterica serovar Typhimurium (S. Typhimurium). Two sRNAs are encoded by the genomic island GEI4417/4436 responsible for myo-inositol (MI) degradation, suggesting a role in the regulation of this metabolic pathway. Read More
Curr Opin Urol 2018 Dec 6. Epub 2018 Dec 6.
Department of Urology, University Health Network.
Purpose Of Review: We present a review of recent literature to summarize the most recent evidence on the use of ureteral stents, including the use of different materials and treatment of stent-related symptoms.
Recent Findings: Metal stents are able to resist lumen occlusion from extrinsic compression allowing longer indwelling time and making them an option for long-term use. Biodegradable stents have the advantage not to require secondary procedures; however, they have not proven their safety in the clinical setting yet. Read More
Biosci Rep 2018 Dec 7. Epub 2018 Dec 7.
Nanjing University, nanjing, China
Apoptosis is widely known as programmed cell death eliciting no inflammatory responses. The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth of knowledge which led to not only a better understanding of the fundamental process, but also potent therapeutic measures of diseases. The classic intrinsic and extrinsic signaling pathways of apoptosis, along with regulatory factors have been well delineated. Read More
J Environ Manage 2018 Dec 6;232:851-857. Epub 2018 Dec 6.
CSIRO L&W, ATSIP Bldg 145, James Cook University, James Cook Dr., Townsville QLD 4811, Australia. Electronic address:
Background: Environmental changes caused by plant pathogen incursions can have significant economic and social impacts on agricultural communities. Proactive and vigilant biosecurity actions on-ground are essential in preventing outbreaks from occurring and/or spreading. However, little is known about psychological drivers for action. Read More
Sci Total Environ 2018 Nov 22;656:778-788. Epub 2018 Nov 22.
Department of Marine Ecology, College of Marine Life Science, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Ecology and Environmental Science, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:
The brominated flame retardant, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), is well documented to exert potential negative impacts on different marine biota. However, the responsible mechanism remains unknown. The rainbow trout gonadal cell line RTG-2 was used as a model, and the mechanism and pathway underlying BDE-47 (6, 12. Read More
Curr Opin Neurobiol 2018 Dec 4;56:33-39. Epub 2018 Dec 4.
Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel. Electronic address:
Experience leaves a lasting mark on neural circuit function in part through activity-regulated gene (ARG) expression. New genome wide approaches have revealed that ARG programs are highly cell-type-specific, raising the possibility that they mediate different forms of experience-dependent plasticity in different cell types. The cell-type specificity of these gene programs is achieved by a combination of cell-intrinsic mechanisms that determine the transcriptional response of each neuronal subtype to a given stimulus and by cell-extrinsic mechanisms that influence the nature of the stimulus a cell receives. Read More
Physiol Behav 2018 Dec 4;199:333-342. Epub 2018 Dec 4.
School of Sport, Health and Exercise Sciences, Bangor University, Bangor, Gwynedd LL57 2PZ, United Kingdom. Electronic address:
Exercise is an important health behavior. Expressed reasons for participation are often delayed outcomes i.e. Read More
Dev Biol 2018 Dec 4. Epub 2018 Dec 4.
European Molecular Biology Laboratory (EMBL), Director's Research Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany; Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences.
The terminal cells of the tracheal epithelium in Drosophila melanogaster are one of the few known cell types that undergo subcellular morphogenesis to achieve a stable, branched shape. During the animal's larval stages, the cells repeatedly sprout new cytoplasmic processes. These grow very long, wrapping around target tissues to which the terminal cells adhere, and are hollowed by a gas-filled subcellular tube for oxygen delivery. Read More
Acta Biomater 2018 Dec 6. Epub 2018 Dec 6.
Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:
Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo microenvironment. In recent years, manipulating the micro- and nano-scale topography of the stem cell niche has gained considerable interest for the purposes of controlling extrinsic mechanical cues to regulate stem cell fate and behavior in vitro. Here, we established an optimal nanotopographical system to improve 3-dimensional (3D) differentiation of pancreatic cells from human pluripotent stem cells (hPSCs) by testing gradient-pattern chips of nano-scale polystyrene surface structures with varying sizes and shapes. Read More
Neoplasia 2018 Dec 4;21(1):82-92. Epub 2018 Dec 4.
Department of Dermatology, University of Wisconsin and the Middleton VA Medical Center, Madison, WI. Electronic address:
Advanced-stage cutaneous T-cell lymphoma (CTCL) is usually a fatal malignancy despite optimal use of currently available treatments. In this preclinical study of novel CTCL therapy, we performed in vitro and ex vivo experiments to determine the efficacy of combination treatment with a panel of BET bromodomain inhibitors (BETi) (JQ1, OTX015, CPI-0610, I-BET762) and HDAC inhibitors (HDACi) (SAHA/Vorinostat, Romidepsin). BETi/HDACi combinations were synergistic (combination index <1) against cell viability and induced G0/G1 cell cycle arrest. Read More
Int J Biol Macromol 2018 Dec 6. Epub 2018 Dec 6.
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. Electronic address:
Bispecific antibodies (BsAbs), are potential theranostics. Chemical procedures of preparation of BsAbs, in which two monospecific antibodies are split into half molecules and heterodimerized, continue to attract attention in view of their simplicity. Poor dissociation of antibodies with reduced inter-heavy chain disulfides into half molecules under neutral conditions however restricts the BsAbs formation. Read More
Neurosci Lett 2018 Dec 5;694:192-197. Epub 2018 Dec 5.
Department of Biochemistry, German University in Cairo, Egypt. Electronic address:
The inability of central nervous system (CNS) to regenerate following traumatic brain injury (TBI) can be attributed to apoptotic cell death, inhibitory extrinsic environment, and the limited ability of neurons to regenerate. Thus, fostering the intrinsic regenerative potential and minimizing neuronal cell death could be a promising therapeutic approach. Pyrroloquinoline quinone (PQQ) was previously reported for its neuroprotective and regenerative potential on peripheral nerves. Read More