J Immunol Methods 2022 06 11;505:113267. Epub 2022 Apr 11.
Department of Parasitology-Mycology, University Hospital of Besancon, Besancon, France; Chrono-Environment Research Team UMR/CNRS-6249, University of Bourgogne Franche-Comté, Besancon, France; Referent Biology Medical Laboratory for the serological diagnosis of hypersensitivity pneumonitis, LBMR-PHS, University Hospital of Besancon, France.
Context: Bird fancier's lung (BFL) is the most prevalent form of hypersensitivity pneumonitis (HP) worldwide. The current techniques used for the serological diagnosis of BFL all use crude extracts from feathers, droppings, and blooms as test antigens, which is associated with a lack of standardization and variability of the results. An antigenic protein, immunoglobulin lambda-like polypeptide-1 (IgLL1), isolated from pigeon droppings, was recently identified to be associated with BFL. Read More