1,008 results match your criteria Extragonadal Germ Cell Tumors


Primary Malignant Thyroid Teratoma: An Institutional Experience.

Thyroid 2019 Feb;29(2):229-236

1 Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Primary malignant thyroid teratomas are very rare tumors (fewer than 35 previously reported cases in the literature) typically affecting young adult women. While prognosis is poor, there have been some reports of successful treatment regimens. Four cases treated successfully are reported, and a review of the existing literature is provided. Read More

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http://dx.doi.org/10.1089/thy.2018.0206DOI Listing
February 2019
1 Read

An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man.

Eur J Case Rep Intern Med 2018 26;5(7):000900. Epub 2018 Jul 26.

Internal Medicine Department, Hospital Beatriz Ângelo, Lisbon, Portugal.

Some 2-5% of germ cell tumours are of extragonadal origin, with a retroperitoneal location being very rare. The majority of retroperitoneal germ cell tumours have metastasized from a testicular tumour. These tumours are diagnosed incidentally or symptomatically and nearly all present with high alpha-fetoprotein and lactate dehydrogenase levels. Read More

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http://dx.doi.org/10.12890/2018_000900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346782PMC
July 2018
1 Read

[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.40DOI Listing
February 2019
1 Read

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

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http://link.springer.com/10.1007/s13193-018-0778-y
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http://dx.doi.org/10.1007/s13193-018-0778-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265192PMC
December 2018
12 Reads

Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.

Pathology 2019 Jan 20;51(1):62-66. Epub 2018 Nov 20.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Teratomas show diverse biologic behaviour and prognosis as well as variable histological features. Importantly, post-pubertal testicular teratomas composed of mature components have a potential for malignant behaviour, in contrast to ovarian dermoid cysts and pre-pubertal testicular teratomas which are considered almost always benign. On the other hand, the biological behaviour and histogenesis of extragonadal teratomas are still not fully elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183021
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http://dx.doi.org/10.1016/j.pathol.2018.10.002DOI Listing
January 2019
14 Reads

Proboscis lateralis: A case report of a rare giant craniofacial teratoma in an infant.

Arch Plast Surg 2018 Nov 15;45(6):578-582. Epub 2018 Nov 15.

Department of Neurosurgery, Khoula Hospital, Muscat, Sultanate of Oman.

Teratomas can occur in almost any region of the body and are the most common extragonadal germ cell childhood tumors. However, craniofacial teratomas are rare. Craniofacial teratomas can present unique features and cause significant functional and aesthetic concerns. Read More

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http://dx.doi.org/10.5999/aps.2017.01739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258982PMC
November 2018
13 Reads

Clinicopathologic Features and Chromosome 12p Status of Pediatric Sacrococcygeal Teratomas: A Multi-institutional Analysis.

Pediatr Dev Pathol 2018 Sep 3:1093526618798771. Epub 2018 Sep 3.

3 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

Chromosome 12p gains are typically present in postpubertal male patients with testicular malignant germ cell tumors, including most teratomas, and absent in pure ovarian teratomas, both mature and immature. We sought to evaluate the clinicopathologic features and chromosome 12p status of pediatric patients with sacrococcygeal teratomas (SCTs) using the institutional databases of 2 tertiary medical centers. Seven mature teratomas (3 pure, 2 with yolk sac tumor, 1 with medulloepithelioma, and 1 with ependymoma) and 3 immature teratomas (2 pure: grade 2 and grade 3 and 1 mixed: grade 3 with yolk sac tumor) were identified. Read More

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http://dx.doi.org/10.1177/1093526618798771DOI Listing
September 2018
6 Reads

[Beta-hCG-producing thymic teratoma: an uncommon cause of peripheral precocious puberty].

Rev Chil Pediatr 2018 Jun;89(3):373-379

Servicio de Pediatría, Hospital Dr. Hernán Henríquez Aravena, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.

Introduction: Among the causes of peripheral precocious puberty in men are the beta-human cho rionic gonadotropin (Β-HCG)-secreting tumors, such as hepatoblastomas, dysgerminomas, chorio carcinomas, and immature teratomas. In pediatrics, the mediastinal teratomas are rare, representing the 7-10% of extragonadal teratomas.

Objective: To describe the case of a patient with peripheral precocious puberty due to a Β-HCG -secreting thymic teratoma. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000304DOI Listing
June 2018
14 Reads

Mixed extragonadal germ cell tumour of the prostate.

BMJ Case Rep 2018 Jul 10;2018. Epub 2018 Jul 10.

Department of Urology and Renal Transplantation, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Extragonadal germ cell tumours (EGGCTs) originated in prostate are extremely rare, with <20 cases described in the literature. We report a case of a patient with a primary prostatic mixed EGGCT. A 47-year-old man presenting severe low urinary tract symptoms and signs of prostatic enlargement, with no malignancy suspicion, underwent transurethral resection of the prostate. Read More

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http://dx.doi.org/10.1136/bcr-2017-223603DOI Listing
July 2018
17 Reads

Retroperitoneal seminoma, a rare cause of testicular pain.

BMJ Case Rep 2018 Jun 14;2018. Epub 2018 Jun 14.

Department of General Surgery, Royal Free London NHS Foundation Trust, London, London, UK.

Extragonadal retroperitoneal seminomas are a rare cause of testicular pain in males. We report the case of a 46-year-old man, who presented with right-sided testicular pain, clinically mimicking testicular torsion. The patient underwent a scrotal exploration, which revealed normal testes. Read More

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http://dx.doi.org/10.1136/bcr-2017-223736DOI Listing
June 2018
5 Reads

Devil within: an incidental and rare finding of an extragonandal retroperitoneal germ cell teratoma carcinoid tumour.

BMJ Case Rep 2018 Jun 14;2018. Epub 2018 Jun 14.

Department of General Surgery, University Hospital Waterford, Waterford, Ireland.

Extragonadal germ cell tumours (GCTs) are uncommon neoplasms comprising approximately 2%-5% of all GCTs. Of these, approximately 30%-40% occurs as primary retroperitoneal GCTs. This case report details the presentation, diagnosis and management of a 53-year-old man presenting with an incidental finding of a primary extragonadal retroperitoneal teratoma with carcinoid transformation. Read More

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http://dx.doi.org/10.1136/bcr-2017-223336DOI Listing
June 2018
16 Reads

Hematologic Malignancies Associated With Mediastinal Germ Cell Tumors: 10 Years' Experience at Thailand's National Pediatric Tertiary Referral Center.

J Pediatr Hematol Oncol 2018 Aug;40(6):450-455

Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok.

Mediastinal germ cell tumor (MGCT), which accounts for 1% to 3% of extragonadal germ cell tumors, has unique manifestations; it is associated with several types of hematologic malignancy, particularly myeloid neoplasm. The aim of this study was to report the 10-year incidence, clinical characteristics, and outcomes of MGCT at Thailand's national pediatric tertiary referral center. This retrospective study included patients diagnosed with MGCT at the Department of Pediatrics, Siriraj Hospital during 2005 to 2014. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001233DOI Listing
August 2018
15 Reads

Is alpha-fetoprotein decline a prognostic factor of childhood non-seminomatous germ cell tumours? Results of the French TGM95 study.

Eur J Cancer 2018 05 28;95:11-19. Epub 2018 Mar 28.

Gustave Roussy, Université Paris-Saclay, Department of Pediatric Oncology, Villejuif, F-94805, France.

Purpose: In adults' non-seminomatous germ cell tumours (NS-GCT), alpha-fetoprotein (AFP) decline was identified as an important prognostic factor. We investigated its prognostic value in the French TGM95 study for childhood NS-GCT.

Patients And Methods: Three risk groups were defined: low risk (LR: localised and completely resected pS1, AFP<15000 ng/ml), with a 'wait-and-see' strategy; intermediate-risk (IR: localised incompletely resected, AFP<15000 ng/ml) with 3-5 vinblastine-bleomycine-cisplatin courses; high risk (HiR: AFP≥15000 ng/ml and/or metastatic) with 4-6 etoposide-ifosfamide-cisplatin courses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183023
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http://dx.doi.org/10.1016/j.ejca.2018.02.029DOI Listing
May 2018
3 Reads

Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report.

BMC Pediatr 2018 03 5;18(1):97. Epub 2018 Mar 5.

Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Germ cell tumors (GCTs) in children are rare neoplasms with diverse pathological findings according to the site and age of presentation. The most common symptoms in children with mediastinal GCTs, which are nonspecific, are dyspnea, chest pain, cough, hemoptysis, vena cava occlusion syndrome, and fatigue/weakness. Because of these nonspecific symptoms, it is difficult to suspect a mediastinal mass. Read More

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http://dx.doi.org/10.1186/s12887-018-1070-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838956PMC
March 2018
18 Reads

Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.

Endocr Rev 2018 08;39(4):389-423

Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.

Although first identified over 70 years ago, Klinefelter syndrome (KS) continues to pose substantial diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of patients with KS are accurately diagnosed and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. Read More

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http://dx.doi.org/10.1210/er.2017-00212DOI Listing
August 2018
11 Reads

Klinefelter syndrome: more than hypogonadism.

Metabolism 2018 Sep 31;86:135-144. Epub 2018 Jan 31.

University Hospital of Muenster, Center of Reproductive Medicine and Andrology, Domagkstraße 11, D-48149, Muenster, Germany.

Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.09.017DOI Listing
September 2018
4 Reads

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.

Stem Cell Res 2018 03 4;27:46-56. Epub 2018 Jan 4.

Department of Molecular, Cell and Developmental Biology, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Los Angeles, CA 90095, USA; University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). Read More

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http://dx.doi.org/10.1016/j.scr.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858915PMC
March 2018
31 Reads

Case report: Extragonadal mixed germ cell tumor in the thigh.

Urol Case Rep 2018 Jan 26;16:104-106. Epub 2017 Nov 26.

King Hussein Cancer Center, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan.

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http://dx.doi.org/10.1016/j.eucr.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724990PMC
January 2018
26 Reads

Diagnosis and management of metastatic neoplasms with unknown primary.

Semin Diagn Pathol 2018 May 26;35(3):199-206. Epub 2017 Nov 26.

Clinical Cooperation Unit Molecular Hematology / Oncology, German Cancer Research Center (DKFZ) and Department of Medicine V, University of Heidelberg, Heidelberg, Germany; Department of Internal Medicine V, Hematology / Oncology, University of Heidelberg, Heidelberg, Germany. Electronic address:

In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.013DOI Listing
May 2018
9 Reads

An Unusual Cause of Headache and Sudden Death of a Young Sailor-Postmortem Computed Tomography and Histological Findings of a Fatal Retroperitoneal Malignant Mixed Germ Cell Tumor.

J Forensic Sci 2018 Sep 22;63(5):1568-1572. Epub 2017 Nov 22.

Department of Anatomical Pathology, Singapore General Hospital, Outram Road, Singapore, 169856, Singapore.

A 26-year-old Caucasian sailor, with no past medical history aside from headache for the last 1 week, was found dead in his cabin. The body was stored in a refrigerator on board and disembarked for autopsy 3 days later. Autopsy showed a large, nodular, necrotic and hemorrhagic retroperitoneal mass, and smaller hemorrhagic nodules in the brain, lungs, liver, and left kidney, with the brain being markedly edematous. Read More

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http://dx.doi.org/10.1111/1556-4029.13703DOI Listing
September 2018
8 Reads

An Uncommon Presentation of a Metachronous Testicular Primary Nonseminoma and Seminoma Separated by Two Decades and a Testicular Cancer Literature Review.

Case Rep Oncol 2017 Sep-Dec;10(3):832-839. Epub 2017 Sep 15.

Cancer Treatment Centers of America, Southwestern Regional Center, Tulsa, OK, USA.

Introduction: Testicular cancer is the most common malignancy in men aged 15-40 years [Bols et al.: Philadelphia, Wolters Kluwer, Lippincott Williams & Wilkins, 2011]. Its incidence comprises 0. Read More

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http://dx.doi.org/10.1159/000478846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649222PMC
September 2017
18 Reads

Yolk sac primary tumor of mediastino: a rare case in a young adult.

Einstein (Sao Paulo) 2017 Oct-Dec;15(4):496-499. Epub 2017 Sep 21.

Instituto de Assistência Médica ao Servidor Público Estadual, Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", São Paulo, SP, Brazil.

Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", complaining about dyspnea and dry cough for 1 year. Read More

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http://dx.doi.org/10.1590/S1679-45082017RC4008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875168PMC
March 2018
37 Reads

Massive Hemoptysis: A Rare Presentation of Anterior Mediastinal Teratoma in an Adolescent.

Indian J Med Paediatr Oncol 2017 Apr-Jun;38(2):215-217

Department of Paediatrics, Government Medical College, Nagpur, Maharashtra, India.

Germ cell tumors are predominantly found in the gonads, and the most common extragonadal site is anterior mediastinum. Usual symptoms are cough, dyspnea, and fever, chest pain due to mass effect or intrapulmonary invasion but hemoptysis is rare and may result from either communication with tracheobronchial tree or may result from bronchial bleeding due to irritation by tumor. As in our case, patient presenting with massive hemoptysis and shock are the rarest presentation of a benign teratoma. Read More

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http://dx.doi.org/10.4103/ijmpo.ijmpo_62_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582563PMC
September 2017
10 Reads

Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9-Year-Old Patient.

Urology 2017 Dec 6;110:216-219. Epub 2017 Sep 6.

Division of Urology, Hospital Universitario San Ignacio and Pontificia Universidad Javeriana School of Medicine, Bogotá D.C., Colombia; Department of Urology, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia.

Less than 5%-7% of germ cell tumors are extragonadal, with the central nervous system being the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one-third of these are pure seminomas (germinomas). We report the case of a 9-year-old boy with development of secondary sexual characteristics. Read More

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http://dx.doi.org/10.1016/j.urology.2017.08.038DOI Listing
December 2017
19 Reads

Split liver transplantation for retroperitoneal immature teratoma masquerading as hepatoblastoma.

Pediatr Transplant 2017 Nov 16;21(7). Epub 2017 Jul 16.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

Extragonadal teratoma originating from the retroperitoneum represents less than 5% of all teratomas and accounts for less than 10% of all pediatric retroperitoneal neoplasms. To date, there has been no report of teratoma managed with LT. This study reports an infant aged 3 months with retroperitoneal immature teratoma involving the hepatic hilum, refractory to chemotherapy and treated with LT. Read More

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http://dx.doi.org/10.1111/petr.13025DOI Listing
November 2017
12 Reads

The Rare Extragonadal Omental Teratoma: A Case Report.

J Minim Invasive Gynecol 2017 Sep - Oct;24(6):1046-1048. Epub 2017 Jun 27.

Department of Obstetrics and Gynecology, Spedali Civili di Brescia, Brescia, Italy.

Teratomas of extragonadal origin are extremely rare, and the most common extragonadal site to find teratomas is the omentum. Teratomas are typically found in women of reproductive age, but they are also seen in young girls and postmenopausal women. Generally, teratomas arise from germ cells that may induce different cells to originate from the 3 primitive embryonic layers. Read More

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http://dx.doi.org/10.1016/j.jmig.2017.05.022DOI Listing
March 2018
4 Reads

Pure Primary Extragonadal Retroperitoneal Yolk Sac Tumour in a Young Child: A Case Report.

J Clin Diagn Res 2017 May 1;11(5):ED09-ED11. Epub 2017 May 1.

Associate Professor, Department of Pathology, Yenepoya Medical College, Mangalore, Karnataka, India.

Germ Cell Tumours (GCTs) in children are uncommon, constituting approximately only 3% of all malignancies in children younger than 15 years of age. Primary extragonadal GCTs constitute only 1-5% of all GCTs and a retroperitoneal site is seen only in 4% of all extragonadal GCTs. Extragonadal GCTs arise from local transformation of primordial germ cells which have been misplaced during the migration of these cells through the midline dorsal mesentery in the fourth-sixth week of embryogenesis. Read More

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http://dx.doi.org/10.7860/JCDR/2017/24892.9781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483680PMC
May 2017
6 Reads

Mediastinal seminoma presenting with superior vena cava syndrome.

BMJ Case Rep 2017 Jun 8;2017. Epub 2017 Jun 8.

Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

We present a rare cause of superior vena cava syndrome (SVC) in a previously healthy male aged 31 years. Malignancy was suspected due to unintentional weight loss and childhood exposure to radioactive fallout from a nuclear facility accident. A very large anterior mediastinal mass was identified and demonstrated to be an extragonadal seminoma. Read More

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http://dx.doi.org/10.1136/bcr-2016-218282DOI Listing
June 2017
13 Reads

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour.

Histopathology 2017 Oct 19;71(4):562-569. Epub 2017 Jul 19.

Department of Pathology, Indiana University, Indianapolis, IN, USA.

Aims: Accurate histological diagnosis and classification of germ cell tumours (GCTs) is key to informing successful therapeutic and surveillance strategy. The modern therapeutic approach for yolk sac tumour (YST) is highly curative. Because YST takes on a large morphological spectrum, it can be confused for other GCT subtypes as well as somatic carcinomas, particularly when YST presents in an extragonadal or a metastatic setting. Read More

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http://doi.wiley.com/10.1111/his.13276
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http://dx.doi.org/10.1111/his.13276DOI Listing
October 2017
20 Reads

A tumor profile in Patau syndrome (trisomy 13).

Am J Med Genet A 2017 Aug 25;173(8):2088-2096. Epub 2017 May 25.

Support Organization for Trisomy 18, 13 and Related Disorders - Surgery Registry (SOFT-SR) Rochester, Rochester, New York.

Individuals with trisomic conditions like Down syndrome and Edwards syndrome are prone to certain types of malignancy. However, for Patau syndrome (constitutional trisomy 13), which occurs in 1/10,000-1/20,000 live births, the tumor profile has not been well characterized. An awareness of susceptibility to malignancies can improve care of affected individuals, as well as further our understanding of the contribution of trisomy to carcinogenesis. Read More

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http://dx.doi.org/10.1002/ajmg.a.38294DOI Listing
August 2017
22 Reads

Primary intrarenal yolk sac tumor.

Indian J Urol 2017 Apr-Jun;33(2):167-168

Department of Pathology, Apollo Hospital, Chennai, Tamil Nadu, India.

Extragonadal germ cell tumors (EGGCTs) usually are not coexistent with a gonadal tumor, hence in a way, are primary and are rare. The origin of primary EGGCT is still a matter of debate. Herewith, we report a patient with primary intrarenal yolk sac tumor in a 43-year-old man. Read More

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http://dx.doi.org/10.4103/0970-1591.203410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396408PMC
May 2017
8 Reads

Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not?

World J Surg Oncol 2017 Apr 13;15(1):85. Epub 2017 Apr 13.

Second Department of Propedeutic Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527, Athens, Greece.

Background: Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance.

Case Presentation: A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. Read More

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http://dx.doi.org/10.1186/s12957-017-1146-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390409PMC
April 2017
11 Reads

Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: Results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Société Française des Cancers de l'Enfant).

Pediatr Blood Cancer 2017 Sep 17;64(9). Epub 2017 Mar 17.

Pediatric Hematology-Oncology Unit, Pellegrin Hospital, CHU Bordeaux, Bordeaux, France.

Purpose: To examine the clinical presentation, treatment and results in children and adolescents with primary mediastinal (PM) and retroperitoneal (RP) germ cell tumors (GCTs).

Methods: The TGM95 trial for malignant GCTs was conducted in France between 1995 and 2005 to evaluate a strategy adapted to prognostic factors with cisplatin-based chemotherapy and surgical management. We reviewed patients with TGCTs at PM and RP sites. Read More

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http://dx.doi.org/10.1002/pbc.26494DOI Listing
September 2017
21 Reads

Primary Retroperitoneal Teratoma with Predominant Neurogenic Elements Masquerading as Adrenal Tumor.

Turk Patoloji Derg 2019 ;35(1):69-73

Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Primary retroperitoneal teratomas are uncommon extragonadal nonseminomatous germ cell tumors that are composed of well differentiated parenchymal tissues which are derived from more than one of the three embryonic germ cell layers. Here we report an unusual and first of its kind, a case of primary mature cystic retroperitoneal teratoma mimicking as adrenal tumor in a 7-month-old female in which the tumor was predominantly composed of neurogenic tissue histologically which is unlike the usual pattern seen in the teratomas. Read More

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http://dx.doi.org/10.5146/tjpath.2016.01365DOI Listing
January 2019
5 Reads

Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group.

J Clin Oncol 2017 Apr 27;35(11):1203-1210. Epub 2017 Feb 27.

Furqan Shaikh, The Hospital for Sick Children, University of Toronto, Toronto, Canada; John W. Cullen, Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, CO; Thomas A. Olson, Children's Healthcare of Atlanta, and Emory University, Atlanta, GA; Farzana Pashankar, Yale University School of Medicine, New Haven, CT; Marcio H. Malogolowkin, University of California Davis Comprehensive Cancer Center, Sacramento; Doojduen Villaluna and Mark Krailo, Children's Oncology Group, Monrovia; Mark Krailo, University of Southern California, Los Angeles, CA; James F. Amatruda, University of Texas Southwestern Medical Center and Children's Medical Center Dallas, Dallas, TX; Deborah F. Billmire and Frederick J. Rescorla, Riley Hospital for Children, Indianapolis, IN; Rachel A. Egler and Jonathan H. Ross, Rainbow Babies and Children's Hospital, Cleveland, OH; Bryan J. Dicken, Stollery Children's Hospital, and University of Alberta Hospital, Edmonton, Alberta, Canada; Marc Schlatter, Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids, MI; Carlos Rodriguez-Galindo, St Jude Children's Research Hospital, Memphis, TN; and A. Lindsay Frazier, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA.

Purpose To investigate whether event-free survival (EFS) can be maintained among children and adolescents with intermediate-risk (IR) malignant germ cell tumors (MGCT) if the administration of cisplatin, etoposide, and bleomycin (PEb) is reduced from four to three cycles and compressed from 5 to 3 days per cycle. Patients and Methods In a phase 3, single-arm trial, patients with IR MGCT (stage II-IV testicular, II-III ovarian, I-II extragonadal, or stage I gonadal tumors with subsequent recurrence) received three cycles of PEb. A parametric comparator model specified that the observed EFS rate should not be significantly < 92%. Read More

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http://dx.doi.org/10.1200/JCO.2016.67.6544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455599PMC
April 2017
26 Reads

Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report.

J Med Case Rep 2017 Feb 20;11(1):47. Epub 2017 Feb 20.

Department of Pediatric Hematology Oncology, UZ Brussel, Jette, Belgium.

Background: Pediatric germ cell tumors account for approximately 3.5 % of all childhood cancers for children under the age of 15 years. Up to one-third are extragonadal neoplasms. Read More

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http://dx.doi.org/10.1186/s13256-017-1216-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317054PMC
February 2017
6 Reads

Hypertestosteronemia and Infertility from a Mediastinal Extragonadal Germ Cell Tumor.

Am J Med 2017 Jun 2;130(6):e261-e263. Epub 2017 Feb 2.

Department of Endocrinology, Diabetes and Metabolism, WISDEM Centre, UHCW NHS Trust, Coventry, United Kingdom; Centre for Reproductive Medicine, UHCW NHS Trust, Coventry, United Kingdom; Division of Translational and Experimental Medicine, University of Warwick Medical School, Coventry, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343173010
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http://dx.doi.org/10.1016/j.amjmed.2017.01.010DOI Listing
June 2017
30 Reads
5.003 Impact Factor

Epidemiological study of paediatric germ cell tumours revealed the incidence and distribution that was expected, but a low mortality rate.

Acta Paediatr 2017 May 22;106(5):779-785. Epub 2017 Feb 22.

Department of Paediatric and Adolescent Haematology and Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Aim: Germ cell tumours (GCTs) are a rare heterogeneous tumour group derived from primordial germ cells, which can be benign or malignant and occur in the gonads or extragonadally. This study mapped the paediatric GCTs in Denmark from 1984 to 2013 to study the incidence and outcome.

Methods: We identified paediatric GCTs from the Danish Childhood Cancer and National Pathology Registries and reviewed the case records for patient characteristics, tumour characteristics and clinical outcome. Read More

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http://dx.doi.org/10.1111/apa.13767DOI Listing
May 2017
22 Reads

Primary Gastric Choriocarcinoma Presenting as a Pregnancy of Unknown Location.

Obstet Gynecol 2017 02;129(2):281-284

Departments of Obstetrics and Gynecology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Background: Pregnancy of unknown location presents a diagnostic challenge, in rare occasions leading to the diagnosis of malignancy. We describe a case of β-hCG-secreting nongestational primary gastric choriocarcinoma presenting as a pregnancy of unknown location.

Case: A 37-year-old woman, gravida 4 para 3013, presented with several days of vaginal bleeding and rising β-hCG level without ultrasound localization of pregnancy. Read More

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http://dx.doi.org/10.1097/AOG.0000000000001808DOI Listing
February 2017
40 Reads

Clinicopathological Analysis of Mediastinal Masses: A Mixed Bag of Non-Neoplastic and Neoplastic Etiologies.

Turk Patoloji Derg 2017 ;33(1):37-46

1Department of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New DELHI, INDIA.

Objective: The mediastinum is the central portion of the thoracic cavity, housing numerous organs and harbouring a mixed bag of non-neoplastic and neoplastic lesions. Accurate diagnosis is essential owing to the widely variable therapeutic and prognostic implications.

Material And Method: Cases of mediastinal masses were retrospectively reviewed from January 2011 till January 2016. Read More

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http://dx.doi.org/10.5146/tjpath.2016.01371DOI Listing
April 2017
14 Reads

Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country.

Turk J Pediatr 2017 ;59(4):410-417

Departments of Biostatistics, Yıldırım Beyazıt University, Ankara, Turkey.

İncesoy-Özdemir S, Ertem U, Şahin G, Bozkurt C, Yüksek N, Ören AC, Balkaya E, Alkan A. Clinical and epidemiological characteristics of children with germ cell tumors: A single center experience in a developing country. Turk J Pediatr 2017; 59: 410-417. Read More

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http://dx.doi.org/10.24953/turkjped.2017.04.007DOI Listing
December 2018
6 Reads

Comparison of the clinical features and hematopoietic stem cell transplantation outcomes of mediastinal malignant germ cell tumors with nonmediastinal extragonadal placements.

Onco Targets Ther 2016 9;9:7445-7450. Epub 2016 Dec 9.

Department of Chest Diseases.

Objective: Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantation between mediastinal and nonmediastinal malignant EGCTs.

Method: Data of the patients with EGCT who were treated and underwent hematopoietic stem cell transplantation at our hospital between 1988 and 2015 were retrieved retrospectively. Read More

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http://dx.doi.org/10.2147/OTT.S107899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158173PMC
December 2016
9 Reads

Primary retroperitoneal seminoma - embryology, histopathology and treatment particularities.

Rom J Morphol Embryol 2016 ;57(3):1045-1050

"Fundeni" Urological Surgery Discipline, 3rd Department, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Center for Uronephrology and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest, Romania;

Introduction: Retroperitoneal seminoma is a very rare form of cancer, with embryological origin represented by primordial germ cells from the urogenital ridges left behind during the fetal development. Extragenital germ cell tumors can also occur in the mediastinum or the pineal gland. The aim of this paper is to outline the particularities and draw embryological, histopatological and treatment conclusions regarding extragonadal germ cell tumors. Read More

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May 2017
15 Reads

Unusual Presentations of Gynecologic Tumors: Extragonadal Yolk Sac Tumor of the Vulva.

Arch Pathol Lab Med 2017 Feb 13;141(2):293-297. Epub 2016 Dec 13.

Extragonadal germ cell tumors are uncommon, and although they morphologically resemble their gonadal counterparts, unexpected gonadal presentation increases the potential for erroneous diagnoses. Yolk sac tumor is a malignant germ cell tumor characterized by an extraembryonic yolk sac line of differentiation, and relative to other germ cell tumors, is characterized by varied and diverse histologic patterns. When occurring outside of typical age parameters or in extragonadal locations, the histologic variability of yolk sac tumor and its tendency to mimic somatic tumors pose diagnostic challenges. Read More

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http://dx.doi.org/10.5858/arpa.2016-0151-SADOI Listing
February 2017
4 Reads

[An Abnormal Alpha-Fetoprotein Fractionation Provides Additional Information: A Case of Retroperitoneal Germ Cell Tumor Accompanied by Liver Cirrhosis Type C].

Rinsho Byori 2016 Dec;64(12):1353-1356

Most of germ cell tumor is gonadal origin. However 5% of malignant germ cell tumors appear in extragonadal organs. Because extragonadal germ cell tumors (EGGCTs) are found anywhere on the midline such as pineal gland, mediastinum and retroperitoneum, the origin of this type of tumor is controversial. Read More

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December 2016
1 Read

Pediatric pineal germinomas: Epigenetic and genomic approach.

Clin Neurol Neurosurg 2017 Jan 19;152:45-51. Epub 2016 Nov 19.

Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freud", Centro Médico Nacional "Siglo XXI", IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06720, Del. Cuauhtémoc, México D.F., Mexico. Electronic address:

Objective: We identify and correlate chromosomal alterations, methylation patterns and gene expression in pediatric pineal germinomas.

Methods: CGH microarray, methylation and gene expression were performed through the Agilent platform. The results were analyzed with MatLab software, MapViewer, DAVID, GeneCards and Hippie. Read More

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http://dx.doi.org/10.1016/j.clineuro.2016.11.012DOI Listing
January 2017
16 Reads

NUT midline carcinoma mimicking a germ cell tumor: a case report.

BMC Cancer 2016 11 17;16(1):895. Epub 2016 Nov 17.

Department of Medical Oncology, Kameda Medical Center, Kamogawa, Chiba, 296-8602, Japan.

Background: NUT midline carcinoma (NMC) is a rare and highly aggressive malignancy. Although more information on NMC has been recently accumulating in the literature, most oncologists and pathologists remain unfamiliar with the clinical and pathologic features of this disease. The clinical features of NMC sometimes mimic those of other malignancies, and NMC can therefore be overlooked if the diagnosis is not suspected. Read More

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http://bmccancer.biomedcentral.com/articles/10.1186/s12885-0
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http://dx.doi.org/10.1186/s12885-016-2944-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114840PMC
November 2016
7 Reads

The present and future of serum diagnostic tests for testicular germ cell tumours.

Nat Rev Urol 2016 12 18;13(12):715-725. Epub 2016 Oct 18.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young adult men and the incidence of these tumours is increasing. Current research priorities in this field include improving overall survival for patients classified as being 'poor-risk' and reducing late effects of treatment for patients classified as 'good-risk'. Testicular GCTs are broadly classified into seminomas and nonseminomatous GCTs (NSGCTs). Read More

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http://dx.doi.org/10.1038/nrurol.2016.170DOI Listing
December 2016
7 Reads

Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor.

Urol Case Rep 2017 Jan 22;10:1-3. Epub 2016 Oct 22.

Louisiana State University, Department of Urology, 1542 Tulane Avenue, New Orleans, LA, 70112, USA.

Germ cell tumors are the most common malignancy in men aged 15-35 years old, with a small percentage presenting in an extragonadal location. These tumors are seldom identified in the gastrointestinal tract. There is increased risk of extragonadal germ cell tumors (EGCT) in men with Klinefelter syndrome (KS). Read More

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http://dx.doi.org/10.1016/j.eucr.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079238PMC
January 2017
10 Reads