1,039 results match your criteria Extragonadal Germ Cell Tumors


Nonseminomatous Extragonadal Germ Cell Tumor Presenting As Early Pericardial Tamponade.

Cureus 2020 Feb 28;12(2):e7131. Epub 2020 Feb 28.

Internal Medicine, King Edward Medical University/Mayo Hospital, Lahore, PAK.

Multiple different types of mediastinal masses may be encountered on imaging techniques in symptomatic and asymptomatic patients. The most frequent mediastinal masses in adults are thymoma, lymphoma, thyroid masses, and germ cell tumors. Potential complications of these masses due to localized invasion include hemoptysis, post-obstructive pneumonia, and superior vena cava syndrome. Read More

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http://dx.doi.org/10.7759/cureus.7131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105248PMC
February 2020

Incidentally discovered primary mediastinal germ cell tumor.

JAAPA 2020 Apr;33(4):35-37

Victoria Wong practices at Fox Chase Cancer Center in Philadelphia, Pa. Daniel M. Geynisman is an assistant professor of medical oncology at Fox Chase Cancer Center. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Most germ cell tumors arise from the testicles and often are self-diagnosed. Extragonadal germ cell tumors are rare and vary greatly in their clinical presentations. This case report describes a 24-year-old man with an unusual presentation for an extragonadal germ cell tumor. Read More

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http://dx.doi.org/10.1097/01.JAA.0000657172.30545.a3DOI Listing

Mixed Germ Cell Tumor of the Endometrium: A Case Report and Literature Review.

Open Med (Wars) 2020 4;15:65-70. Epub 2020 Feb 4.

Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou 350014, People's Republic of China.

Germ cell tumors (GCTs) localized extragonadally are rare, with only 14 reported cases of a yolk sac tumor in the endometrium. Here we report a case of mixed endometrium GCTs in a 65-year-old postmenopausal woman with abnormal vaginal bleeding. An ultrasound examination showed an oval-shaped mass in the patient's uterine cavity. Read More

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http://dx.doi.org/10.1515/med-2020-0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005913PMC
February 2020

Systemic therapy for primary and extragonadal germ cell tumors: prognosis and nuances of treatment.

Transl Androl Urol 2020 Jan;9(Suppl 1):S56-S65

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Testicular germ cell tumors are the most common solid tumors in young men. These cancers represent a success story of modern medicine in our ability to cure young patients and offer decades of life, with a 5-year survival rate of approximately 95%. This review outlines the staging and risk classification of testicular cancers, and reviews the current state of knowledge and standard of care for the systemic treatment of testicular germ cell tumors with chemotherapy, focusing on the relevant clinical data supporting each treatment regimen. Read More

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http://dx.doi.org/10.21037/tau.2019.09.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995840PMC
January 2020

Primary Paravertebral Germ Cell Tumor Demonstrated by FDG PET/CT.

Clin Nucl Med 2020 Apr;45(4):322-323

From the Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Extragonadal germ cell tumors are rare. Most of these tumors occur in the anterior mediastinum, retroperitoneum, pineal gland, or suprasellar region. Here, we present a case of a 29-year-old man with a paravertebral mass to the right of the T8 and T9 vertebral bodies on MRI and FDG PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002953DOI Listing

Bladder teratoma in a maned wolf .

Open Vet J 2019 10 11;9(3):259-262. Epub 2019 Sep 11.

Texas A&M Veterinary Medical Teaching Hospital, Department of Zoological Medicine, 408 Raymond Stotzer Parkway, College Station, TX 77845, USA.

Background: Teratomas are germ cell tumors, comprised of a mixture of tissue types and with tissue foreign to their site of origin.

Case Description: A 5.5-year-old intact female maned wolf (Chrysocyon brachyurus) was treated for recurrent stranguria and suspected cystitis. Read More

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http://dx.doi.org/10.4314/ovj.v9i3.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794395PMC
October 2019

A Rare Case of Intracranial Nongerminomatous Germ Cell Tumor in a 21-Year-Old Romanian Male.

Case Rep Oncol Med 2020 3;2020:3787250. Epub 2020 Jan 3.

Department of Neurological Critical Care Medicine, AtlantiCare Regional Medical Center, 1925 Pacific Avenue, Atlantic City, NJ, USA.

Extragonadal germ cell tumors are a rare entity that is more prevalent in infants and young children, with preference to midline structures. The category of intracranial germ cell tumors is divided into pure germ cell tumors (GCTs) versus nongerminomatous germ cell tumors (NGGCTs). They are usually present in the second decade of life with a male preponderance. Read More

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http://dx.doi.org/10.1155/2020/3787250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964716PMC
January 2020

Primary malignant mediastinal germ cell tumors: A single institutional experience.

South Asian J Cancer 2020 Jan-Mar;9(1):27-29

Department of Radiotherapy, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Background: Primary mediastinal malignant germ cell tumour (PMMGCT) is rare with unsatisfactory prognosis and pose difficulty in management due to lack of guidelines.

Methods: All cases of PMMGCT diagnosed and treated between years 2014 to 2018 were retrospectively evaluated for clinico-pathological features, multimodality treatment and follow up.

Results: Among a total of five PMMGCT cases, three were seminomatous and two were non seminomatous tumour [Yolk- sac tumour (n-1) and Mixed tumour (n-1)]. Read More

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http://dx.doi.org/10.4103/sajc.sajc_47_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956594PMC
January 2020

A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome.

Turk J Pediatr 2019 ;61(3):456-459

Divisions of Radiology, Ankara Children's Hematology and Oncology Education and Research Hospital, Ankara, Turkey.

Özyörük D, Kocayozgat A, Yaman-Bajin İ, Çetindağ F, Oğuz- Erdoğan AS, Güneş A. A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. Turk J Pediatr 2019; 61: 456-459. Read More

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http://dx.doi.org/10.24953/turkjped.2019.03.024DOI Listing
January 2019

Primary extragonadal yolk sac tumor originating from adrenal gland.

Can J Urol 2019 Dec;26(6):10064-10066

Department of Urology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Extragonadal germ cell tumors are germ cell tumors with no evidence of a primary tumor within the gonads, most often located in the mediastinum or retroperitoneum. We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland. Read More

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December 2019

[Hyperthyroidism as a diagnostic key to advanced choriocarcinoma. An unusual association].

Medicina (B Aires) 2019 ;79(5):411-414

Servicio de Clínica Médica, Sanatorio San José, Buenos Aires, Argentina. E-mail:

Hyperthyroidism is a relatively frequent condition with multiple causes. The most common cause is Graves' disease; followed by hyperthyroid multinodular goiter and toxic adenoma. Association between hyperthyroidism and cancer is infrequent in daily practice. Read More

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December 2019
1 Read

Primary posterior mediastinal germ cell tumor in a child.

Turk Pediatri Ars 2019 25;54(3):185-188. Epub 2019 Sep 25.

2 Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.

Yolk sac tumor is the most common malignant neoplasm of germ cell origin and usually occurs in infant testes or ovaries. On rare occasions, the tumor arises from extragonadal sites, including the sacrococcygeal region, uterus, vagina, prostate, retroperitoneum, liver, mediastinum (commonly in the anterior), pineal gland, and third ventricle. Yolk sac tumors have an unfavorable prognosis, if not treated aggressively. Read More

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http://dx.doi.org/10.14744/TurkPediatriArs.2019.88155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776447PMC
September 2019
1 Read

Salvage sacrococcygeal resection for yolk sac tumors after chemotherapy: report of 2 cases.

J Neurosurg Pediatr 2019 Oct 4:1-8. Epub 2019 Oct 4.

1Division of Pediatric Neurosurgery, Department of Surgery, Texas Children's Hospital, Baylor College of Medicine.

Pediatric germ cell tumors (GCTs) are neoplasms that originate from primordial germ cells and, according to their site of presentation, are classified as gonadal or extragonadal. The most common site of extragonadal GCTs in children is the sacrococcygeal region, and the standard management is multimodal with a focus on chemotherapy. In selected instances, sacrococcygeal resection is performed. Read More

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http://dx.doi.org/10.3171/2019.7.PEDS19321DOI Listing
October 2019
4 Reads

Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features.

Cancer Med 2019 Nov 30;8(16):6832-6840. Epub 2019 Sep 30.

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. Read More

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http://dx.doi.org/10.1002/cam4.2195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853824PMC
November 2019
3 Reads

A Rare Case of Mediastinal Non-seminomatous Germ Cell Tumour with Acute Megakaryocytic Leukaemia.

J Assoc Physicians India 2019 Jul;67(7):88-89

Resident, Dept. of Medicine, INHS Asvini, Mumbai, Maharashtra.

The most common extragonadal site of Nonseminomatous Germ Cell Tumours is the mediastinum. These are similar to their gonadal counterparts in histology but have a poorer prognosis. The association of mediastinal germ cell tumours with blood borne malignancies has been established in many case reports. Read More

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July 2019
1 Read

Playing the long surveillance ball game: Metachronous testicular tumor developing after treatment and remission of extragonadal germ cell tumor.

Rare Tumors 2019 9;11:2036361319873196. Epub 2019 Sep 9.

Rush University Medical Center, Chicago, IL, USA.

A 32-year-old man with vague abdominal pain was found to have enlarged para-aortic and mediastinal lymph nodes on computed tomography. He was diagnosed with retroperitoneal mixed germ cell tumor as confirmed on percutaneous biopsy. At the time of diagnosis, lactic dehydrogenase, human beta-chorionic gonadotropin, and alpha-fetoprotein were elevated. Read More

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http://dx.doi.org/10.1177/2036361319873196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734599PMC
September 2019
3 Reads

Squamous cell carcinoma as a somatic-type malignancy in an extragonadal immature teratoma of the sinonasal region.

Int J Pediatr Otorhinolaryngol 2019 Nov 12;126:109639. Epub 2019 Aug 12.

Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, 110029, India.

Somatic-type malignancy arising in a teratoma of the sinonasal region is extremely unusual, creating a diagnostic dilemma. There are no definite guidelines for management of such cases. A 15-year-old male with a maxillary mass was misdiagnosed as angiomyolipoma, maxillary carcinoma, mucoepidermoid carcinoma, and teratocarcinosarcoma, followed by the final diagnosis of squamous cell carcinoma arising in an immature teratoma. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.109639DOI Listing
November 2019

Human germ cell tumours from a developmental perspective.

Nat Rev Cancer 2019 09 14;19(9):522-537. Epub 2019 Aug 14.

Laboratory for Experimental Patho-Oncology, Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.

Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites, where migrating primordial germ cells are located during embryogenesis. This group of heterogeneous neoplasms is unique in that their developmental potential is in effect determined by the latent potency state of their cells of origin, which are reprogrammed to omnipotent, totipotent or pluripotent stem cells. Read More

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http://dx.doi.org/10.1038/s41568-019-0178-9DOI Listing
September 2019

Survival differences by race/ethnicity among children and adolescents diagnosed with germ cell tumors.

Int J Cancer 2020 May 31;146(9):2433-2441. Epub 2019 Jul 31.

Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN.

Survival differences by racial and ethnic group have been reported in children and adolescents with germ cell tumors (GCTs), but whether these differences depend on stage of disease is unclear. Using the SEER 18 registries (2000-2015), we examined GCT survival differences by race/ethnicity (non-Hispanic white [NHW], Black, Asian/Pacific Islander [API], Hispanic) separately for males and females aged 0-19 years at diagnosis. We used Kaplan-Meier survival curves (Log-Rank p values) to characterize survival differences. Read More

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http://dx.doi.org/10.1002/ijc.32569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960364PMC
May 2020
5 Reads

A Giant Primary Mediastinal Teratocarcinoma in a Male Adult.

Case Rep Surg 2019 10;2019:7123241. Epub 2019 Jun 10.

Department of Pathology, Bahrain Defense Force Hospital, Riffa, Bahrain.

Germ cell tumors (GCTs) arise along the midline, in which 50-70% of extragonadal GCTs occur in the mediastinum. Malignant GCTs are more common in males, while benign GCTs occur equally in both males and females. This report presents a case of a giant primary mediastinal nonseminomatous GCT resected from a 35-year-old male who presented with dyspnoea and tightness in the chest. Read More

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http://dx.doi.org/10.1155/2019/7123241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590609PMC
June 2019
7 Reads

A case of cervical spinal mass with cord compression and rib bone metastasis from presumably burned-out seminomatous testicular germ cell tumor.

Can J Urol 2019 06;26(3):9799-9801

Department of Internal Medicine, St. Joseph's University Medical Center, Paterson, New Jersey, USA.

Most germ cell tumors are located in the gonads however there are instances where these tumors are located elsewhere in which are termed extragonadal germ cell tumors. When primary lesion of the testicular tumor has regressed, the term "burned-out testicular tumor" has been proposed. We herein report the first case of burned-out seminoma of the testis presenting as a cervical spinal mass causing cord compression with bone metastasis. Read More

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June 2019
6 Reads

Identification of testicular cancer driver genes by a cross-species comparative oncology approach.

Andrology 2019 07 13;7(4):545-554. Epub 2019 May 13.

Departments of Pediatrics and Molecular Biology, University of Texas Southwestern Medical, Dallas, TX, USA.

Background: Germ cell tumors arise in the testis, ovary, or extragonadal locations and have a wide range of histopathological and clinical presentations. The relative lack of animal models of germ cell tumors has impeded functional assessment of candidate driver genes. Previously, we described the development of testicular germ cell tumors in zebrafish carrying a mutation in bmpr1bb, a BMP family receptor, and demonstrated that human germ cell tumors have defects in BMP signaling. Read More

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http://dx.doi.org/10.1111/andr.12644DOI Listing
July 2019
9 Reads

Primary mediastinal germ cell tumors.

Semin Oncol 2019 04 24;46(2):107-111. Epub 2019 Apr 24.

Division of Medical Oncology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Italy; Cellular Therapy and Immunobiology Working Party, EBMT.

Backgroud: Germ cell tumors (GCTs) are a group of neoplasms usually arising in the gonads, and very rarely in sites outside the gonads, mainly in the retroperitoneum, the anterior mediastinum, and pineal gland or the coccyx (mainly in childhood). The prognosis of nonseminoma primary mediastinal GCTs (PMGCTs), is considered to be poorer compared to its retroperitoneal or gonadal counterparts and, according to the International Germ Cell Cancer Collaborative Group, it is considered by definition as a "poor risk" disease.

Material And Methods: Our review highlights the clinical features, prognostic factors, and therapeutic strategies in PMGCTs, as described in medical literature. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2019.04.001DOI Listing
April 2019
11 Reads

TdT expression in germ cell tumours: a possible immunohistochemical cross-reaction and diagnostic pitfall.

J Clin Pathol 2019 Aug 4;72(8):536-541. Epub 2019 May 4.

Department of Medicine and Surgery, University Milan Bicocca, Milan, Italy

Aims: Very recent papers proposed a possible role for the expression of terminal deoxynucleotidyl transferase (TdT) in the tumourigenesis of gonadal and extragonadal germ cell-derived tumours (GCTs). Our multicentric study evaluated the magnitude of the immunoreactivity for TdT in GCTs, encompassing seminoma, dysgerminoma, mature teratoma and mixed GCTs.

Methods And Results: The histological series was stained with both monoclonal and polyclonal antibodies, yielding a positivity of 80% of cases with well-defined nuclear reactivity. Read More

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http://dx.doi.org/10.1136/jclinpath-2019-205713DOI Listing
August 2019
10 Reads
2.915 Impact Factor

The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy.

BMC Cancer 2019 Apr 30;19(1):408. Epub 2019 Apr 30.

Department of Informatics, Discovery & Analytical Solutions, PerkinElmer, Shanghai, No.1670, Zhang Heng Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, China.

Background: A tumor comprising of different types of tissues (such as hair, muscle, bone, etc.) is known as a teratoma. It is a type of germ cell (cells that make sperm or eggs) tumor. Read More

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http://dx.doi.org/10.1186/s12885-019-5598-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492338PMC
April 2019
9 Reads

Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017.

Pediatr Int 2019 Jul 18;61(7):672-678. Epub 2019 Jun 18.

Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Sacrococcygeal teratoma (SCT) is the most common extragonadal germ cell tumor in neonates and infants. Although most cases of infantile SCT are benign tumors by nature, some develop into extremely large lesions, leading to massive bleeding, high-output heart failure, disseminated intravascular coagulation, and even fatal outcomes during the neonatal period. In addition, some patients may present with tumor recurrence, malignant transformation, long-term sequelae (including bladder and bowel dysfunction) and lower leg palsy during the long-term follow up. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13844
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http://dx.doi.org/10.1111/ped.13844DOI Listing
July 2019
23 Reads

Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report.

Authors:
Ruili Li Hongjun Li

BMC Cancer 2019 Mar 18;19(1):244. Epub 2019 Mar 18.

Department of Radiology, Beijing Youan Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing, 100069, China.

Background: Nonseminomatous germ cell tumors (NSGCTs) represent one of the main groups of germ cell tumors (GCTs), and they have a more invasive course than seminomatous GCTs. Human immunodeficiency virus (HIV) positivity is considered to be a risk factor for testicular seminoma patients, but reports about HIV-infected individuals with NSGCTs are rare.

Case Presentation: We report a case of a retroperitoneal mixed extragonadal germ cell tumor in an HIV-infected man who has been diagnosed with bilateral cryptorchidism since birth. Read More

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http://dx.doi.org/10.1186/s12885-019-5456-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423750PMC
March 2019
10 Reads

The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary.

J Ovarian Res 2019 Mar 11;12(1):22. Epub 2019 Mar 11.

Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnóstico -CEBBAD Universidad Maimónides, C1405BCK, Buenos Aires, Argentina.

Background: Normal pubertal ovary displays all stages of follicular development and a biased BAX/BCL2 protein ratio in favor of pro-apoptotic BAX protein comparable to the adult ovary. However, adolescents suffering malignant extra-gonadal disease show a limited follicle development after cytotoxic drug treatment and a reduced capacity of in vitro follicle growth. We evaluated the expression of pro- and anti-apoptotic members of the BCL2 gene family, the FAS/FAS-L proteins from the extrinsic apoptosis pathway, the germ-cell-specific marker VASA, the pluripotency marker OCT3/4, and markers of early and late apoptosis in the ovary of pubertal patients with malignant extra-gonadal disease, which received or not pre-surgery chemotherapy, entering a cryopreservation program. Read More

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http://dx.doi.org/10.1186/s13048-019-0496-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410530PMC
March 2019
24 Reads

Autologous Hematopoietic Stem Cell Transplantation for Male Germ Cell Tumors: Improved Outcomes Over 3 Decades.

Biol Blood Marrow Transplant 2019 06 20;25(6):1099-1106. Epub 2019 Feb 20.

Medical College of Wisconsin, Milwaukee, Wisconsin.

The curative potential of autologous hematopoietic cell transplantation (autoHCT) for male germ cell tumors (GCTs) is well established. The optimal timing and number (single transplant [ST] versus tandem transplants [TT] versus triple transplants) of autoHCT are controversial, with wide practice variations. We examined survival trends among 2395 recipients of autoHCT for male GCTs between 1990 and 2015 reported to the Center for International Blood and Marrow Transplant Research. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559839PMC
June 2019
37 Reads

Primary Malignant Thyroid Teratoma: An Institutional Experience.

Thyroid 2019 02;29(2):229-236

1 Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Primary malignant thyroid teratomas are very rare tumors (fewer than 35 previously reported cases in the literature) typically affecting young adult women. While prognosis is poor, there have been some reports of successful treatment regimens. Four cases treated successfully are reported, and a review of the existing literature is provided. Read More

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http://dx.doi.org/10.1089/thy.2018.0206DOI Listing
February 2019
8 Reads

An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man.

Eur J Case Rep Intern Med 2018 26;5(7):000900. Epub 2018 Jul 26.

Internal Medicine Department, Hospital Beatriz Ângelo, Lisbon, Portugal.

Some 2-5% of germ cell tumours are of extragonadal origin, with a retroperitoneal location being very rare. The majority of retroperitoneal germ cell tumours have metastasized from a testicular tumour. These tumours are diagnosed incidentally or symptomatically and nearly all present with high alpha-fetoprotein and lactate dehydrogenase levels. Read More

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http://dx.doi.org/10.12890/2018_000900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346782PMC
July 2018
8 Reads

[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.40DOI Listing
February 2019
11 Reads

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

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http://link.springer.com/10.1007/s13193-018-0778-y
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http://dx.doi.org/10.1007/s13193-018-0778-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265192PMC
December 2018
36 Reads

Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.

Pathology 2019 Jan 20;51(1):62-66. Epub 2018 Nov 20.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Teratomas show diverse biologic behaviour and prognosis as well as variable histological features. Importantly, post-pubertal testicular teratomas composed of mature components have a potential for malignant behaviour, in contrast to ovarian dermoid cysts and pre-pubertal testicular teratomas which are considered almost always benign. On the other hand, the biological behaviour and histogenesis of extragonadal teratomas are still not fully elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183021
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http://dx.doi.org/10.1016/j.pathol.2018.10.002DOI Listing
January 2019
51 Reads

Proboscis lateralis: A case report of a rare giant craniofacial teratoma in an infant.

Arch Plast Surg 2018 Nov 15;45(6):578-582. Epub 2018 Nov 15.

Department of Neurosurgery, Khoula Hospital, Muscat, Sultanate of Oman.

Teratomas can occur in almost any region of the body and are the most common extragonadal germ cell childhood tumors. However, craniofacial teratomas are rare. Craniofacial teratomas can present unique features and cause significant functional and aesthetic concerns. Read More

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http://dx.doi.org/10.5999/aps.2017.01739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258982PMC
November 2018
42 Reads

Clinicopathologic Features and Chromosome 12p Status of Pediatric Sacrococcygeal Teratomas: A Multi-institutional Analysis.

Pediatr Dev Pathol 2019 May-Jun;22(3):214-220. Epub 2018 Sep 3.

3 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

Chromosome 12p gains are typically present in postpubertal male patients with testicular malignant germ cell tumors, including most teratomas, and absent in pure ovarian teratomas, both mature and immature. We sought to evaluate the clinicopathologic features and chromosome 12p status of pediatric patients with sacrococcygeal teratomas (SCTs) using the institutional databases of 2 tertiary medical centers. Seven mature teratomas (3 pure, 2 with yolk sac tumor, 1 with medulloepithelioma, and 1 with ependymoma) and 3 immature teratomas (2 pure: grade 2 and grade 3 and 1 mixed: grade 3 with yolk sac tumor) were identified. Read More

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http://dx.doi.org/10.1177/1093526618798771DOI Listing
September 2019
32 Reads

[Beta-hCG-producing thymic teratoma: an uncommon cause of peripheral precocious puberty].

Rev Chil Pediatr 2018 Jun;89(3):373-379

Servicio de Pediatría, Hospital Dr. Hernán Henríquez Aravena, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.

Introduction: Among the causes of peripheral precocious puberty in men are the beta-human cho rionic gonadotropin (Β-HCG)-secreting tumors, such as hepatoblastomas, dysgerminomas, chorio carcinomas, and immature teratomas. In pediatrics, the mediastinal teratomas are rare, representing the 7-10% of extragonadal teratomas.

Objective: To describe the case of a patient with peripheral precocious puberty due to a Β-HCG -secreting thymic teratoma. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000304DOI Listing
June 2018
22 Reads

Mixed extragonadal germ cell tumour of the prostate.

BMJ Case Rep 2018 Jul 10;2018. Epub 2018 Jul 10.

Department of Urology and Renal Transplantation, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Extragonadal germ cell tumours (EGGCTs) originated in prostate are extremely rare, with <20 cases described in the literature. We report a case of a patient with a primary prostatic mixed EGGCT. A 47-year-old man presenting severe low urinary tract symptoms and signs of prostatic enlargement, with no malignancy suspicion, underwent transurethral resection of the prostate. Read More

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http://dx.doi.org/10.1136/bcr-2017-223603DOI Listing
July 2018
43 Reads

Retroperitoneal seminoma, a rare cause of testicular pain.

BMJ Case Rep 2018 Jun 14;2018. Epub 2018 Jun 14.

Department of General Surgery, Royal Free London NHS Foundation Trust, London, London, UK.

Extragonadal retroperitoneal seminomas are a rare cause of testicular pain in males. We report the case of a 46-year-old man, who presented with right-sided testicular pain, clinically mimicking testicular torsion. The patient underwent a scrotal exploration, which revealed normal testes. Read More

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http://dx.doi.org/10.1136/bcr-2017-223736DOI Listing
June 2018
15 Reads

Devil within: an incidental and rare finding of an extragonandal retroperitoneal germ cell teratoma carcinoid tumour.

BMJ Case Rep 2018 Jun 14;2018. Epub 2018 Jun 14.

Department of General Surgery, University Hospital Waterford, Waterford, Ireland.

Extragonadal germ cell tumours (GCTs) are uncommon neoplasms comprising approximately 2%-5% of all GCTs. Of these, approximately 30%-40% occurs as primary retroperitoneal GCTs. This case report details the presentation, diagnosis and management of a 53-year-old man presenting with an incidental finding of a primary extragonadal retroperitoneal teratoma with carcinoid transformation. Read More

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http://dx.doi.org/10.1136/bcr-2017-223336DOI Listing
June 2018
27 Reads

Hematologic Malignancies Associated With Mediastinal Germ Cell Tumors: 10 Years' Experience at Thailand's National Pediatric Tertiary Referral Center.

J Pediatr Hematol Oncol 2018 08;40(6):450-455

Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok.

Mediastinal germ cell tumor (MGCT), which accounts for 1% to 3% of extragonadal germ cell tumors, has unique manifestations; it is associated with several types of hematologic malignancy, particularly myeloid neoplasm. The aim of this study was to report the 10-year incidence, clinical characteristics, and outcomes of MGCT at Thailand's national pediatric tertiary referral center. This retrospective study included patients diagnosed with MGCT at the Department of Pediatrics, Siriraj Hospital during 2005 to 2014. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001233DOI Listing
August 2018
27 Reads

Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.

Int J Urol 2018 07 11;25(7):678-683. Epub 2018 May 11.

Department of Urology, Kyoto Prefecture University of Medicine, Kyoto, Japan.

Objectives: To analyze cases of therapy-related acute myeloid leukemia and myelodysplastic syndrome diagnosed after chemotherapy for refractory testicular and extragonadal germ cell tumor in our experience.

Methods: A total of 171 consecutive patients who were diagnosed and treated as refractory germ cell tumor and had records of detailed chemotherapy doses between April 1998 and December 2015 were retrospectively reviewed.

Results: Four testicular tumor patients (4/171, 2. Read More

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http://dx.doi.org/10.1111/iju.13597DOI Listing
July 2018
11 Reads

Is alpha-fetoprotein decline a prognostic factor of childhood non-seminomatous germ cell tumours? Results of the French TGM95 study.

Eur J Cancer 2018 05 28;95:11-19. Epub 2018 Mar 28.

Gustave Roussy, Université Paris-Saclay, Department of Pediatric Oncology, Villejuif, F-94805, France.

Purpose: In adults' non-seminomatous germ cell tumours (NS-GCT), alpha-fetoprotein (AFP) decline was identified as an important prognostic factor. We investigated its prognostic value in the French TGM95 study for childhood NS-GCT.

Patients And Methods: Three risk groups were defined: low risk (LR: localised and completely resected pS1, AFP<15000 ng/ml), with a 'wait-and-see' strategy; intermediate-risk (IR: localised incompletely resected, AFP<15000 ng/ml) with 3-5 vinblastine-bleomycine-cisplatin courses; high risk (HiR: AFP≥15000 ng/ml and/or metastatic) with 4-6 etoposide-ifosfamide-cisplatin courses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183023
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http://dx.doi.org/10.1016/j.ejca.2018.02.029DOI Listing
May 2018
4 Reads

Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report.

BMC Pediatr 2018 03 5;18(1):97. Epub 2018 Mar 5.

Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Germ cell tumors (GCTs) in children are rare neoplasms with diverse pathological findings according to the site and age of presentation. The most common symptoms in children with mediastinal GCTs, which are nonspecific, are dyspnea, chest pain, cough, hemoptysis, vena cava occlusion syndrome, and fatigue/weakness. Because of these nonspecific symptoms, it is difficult to suspect a mediastinal mass. Read More

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http://dx.doi.org/10.1186/s12887-018-1070-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838956PMC
March 2018
34 Reads

Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology.

Endocr Rev 2018 08;39(4):389-423

Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.

Although first identified over 70 years ago, Klinefelter syndrome (KS) continues to pose substantial diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of patients with KS are accurately diagnosed and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. Read More

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http://dx.doi.org/10.1210/er.2017-00212DOI Listing
August 2018
27 Reads

Klinefelter syndrome: more than hypogonadism.

Metabolism 2018 09 31;86:135-144. Epub 2018 Jan 31.

University Hospital of Muenster, Center of Reproductive Medicine and Andrology, Domagkstraße 11, D-48149, Muenster, Germany.

Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Read More

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http://dx.doi.org/10.1016/j.metabol.2017.09.017DOI Listing
September 2018
8 Reads

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.

Stem Cell Res 2018 03 4;27:46-56. Epub 2018 Jan 4.

Department of Molecular, Cell and Developmental Biology, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Los Angeles, CA 90095, USA; University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). Read More

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http://dx.doi.org/10.1016/j.scr.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858915PMC
March 2018
72 Reads

Case report: Extragonadal mixed germ cell tumor in the thigh.

Urol Case Rep 2018 Jan 26;16:104-106. Epub 2017 Nov 26.

King Hussein Cancer Center, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan.

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http://dx.doi.org/10.1016/j.eucr.2017.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724990PMC
January 2018
52 Reads

Diagnosis and management of metastatic neoplasms with unknown primary.

Semin Diagn Pathol 2018 May 26;35(3):199-206. Epub 2017 Nov 26.

Clinical Cooperation Unit Molecular Hematology / Oncology, German Cancer Research Center (DKFZ) and Department of Medicine V, University of Heidelberg, Heidelberg, Germany; Department of Internal Medicine V, Hematology / Oncology, University of Heidelberg, Heidelberg, Germany. Electronic address:

In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. Read More

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http://dx.doi.org/10.1053/j.semdp.2017.11.013DOI Listing
May 2018
19 Reads