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    1111 results match your criteria Extracorporeal Photopheresis

    1 OF 23

    How to perform extracorporeal photopheresis via port catheter.
    Transfusion 2017 Aug 7. Epub 2017 Aug 7.
    Department of Dermatology, Venereology and Allergology, University of Leipzig, Leipzig, Germany.
    Background: Extracorporeal photopheresis (ECP) is commonly performed via peripheral venous access catheter. If this is not possible, a tunneled central venous catheter may be considered. However, this access mode may be associated with high complication rates. Read More

    UK National Audit of Extracorporeal Photopheresis in CTCL.
    Br J Dermatol 2017 Aug 7. Epub 2017 Aug 7.
    University Hospital Birmingham, Birmingham, UK.
    We performed a national audit of extracorporeal photopheresis (ECP) in cutaneous T-cell lymphoma (CTCL) to gather information on number of treatment cycles, treatment duration and reason for stopping. UK Consensus Guidelines and European ECP Guidelines recommend that ECP can be considered for first-line treatment for erythrodermic CTCL patients with blood involvement [1,2,3]. Publications have shown effectiveness of ECP in early-stage MF, stage IA-IIA [4,5] and ECP is listed as a systemic treatment option in refractory early-stage MF in the National Comprehensive Cancer Network Guidelines [6]. Read More

    Analysis of long term CD4+CD25highCD127- T-reg cells kinetics in peripheral blood of lung transplant recipients.
    BMC Pulm Med 2017 Jul 18;17(1):102. Epub 2017 Jul 18.
    Department of Internal Medicine, University of Pavia, Pavia, Italy.
    Background: The role of CD4(+)CD25(high)CD127(-) T-reg cells in solid-organ Transplant (Tx) acceptance has been extensively studied. In previous studies on kidney and liver recipients, peripheral T-reg cell counts were associated to graft survival, while in lung Tx, there is limited evidence for similar findings. This study aims to analyze long term peripheral kinetics of T-reg-cells in a cohort of lung recipients and tests its association to several clinical variables. Read More

    Photopheresis Provides Significant Long-Lasting Benefit in Nephrogenic Systemic Fibrosis.
    Case Rep Dermatol Med 2017 12;2017:3240287. Epub 2017 Jun 12.
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.
    Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy, is a rare complication of exposure to gadolinium-based contrast agents in patients who have significantly decreased renal function. Manifestations include fibrosis of the skin and other tissues. Effective therapies are lacking. Read More

    Nephrogenic systemic fibrosis.
    Clin Case Rep 2017 Jul 16;5(7):1184-1185. Epub 2017 May 16.
    Division of Nephrology, Hypertension and Renal TransplantationUniversity of FloridaGainesvilleFlorida.
    Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder seen in patients with renal dysfunction, commonly precipitated by administration of gadolinium contrast. There is no consistently successful treatment, but oral steroids, topical dovonex, extracorporeal photopheresis, and plasmapheresis have been tried [http://www.icnfdr. Read More

    In vitro effects of different 8-methoxypsoralen treatment protocols for extracorporeal photopheresis on mononuclear cells.
    Cent Eur J Immunol 2017 8;42(1):1-9. Epub 2017 May 8.
    University Medical Center Göttingen, Göttingen, Germany.
    Extracorporeal photopheresis (ECP) is an important second-line therapy for graft-versus-host disease. A central therapeutic mechanism is the induction of immune tolerance through apoptosis in patient's leukocytes, caused by ex vivo incubation with 8-methoxypsoralen (8-MOP) and subsequent UVA irradiation. We hypothesized that different 8-MOP incubation times and an additional 8-MOP removal step could influence the apoptosis kinetics of leukocytes in general and in particular could lead to different apoptotic levels in the leukocyte subpopulations. Read More

    Therapy options for chronic lung allograft dysfunction-bronchiolitis obliterans syndrome following first-line immunosuppressive strategies: A systematic review.
    J Heart Lung Transplant 2017 May 29. Epub 2017 May 29.
    Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
    Background: Long-term success of lung transplantation is limited by the development of chronic lung allograft dysfunction (CLAD), of which bronchiolitis obliterans syndrome (BOS) is the most common form. This systematic review sought to identify the current evidence base for CLAD-BOS therapies after initial immunosuppressive treatment strategies.

    Methods: The MEDLINE, Embase, and Cochrane Library databases from inception to May 3, 2016, were searched using keywords relating to CLAD-BOS, study designs, and treatments of interest, including extracorporeal photopheresis (ECP), aerosolized cyclosporine, total lymphoid irradiation (TLI), alemtuzumab, and montelukast. Read More

    Lung transplant recipients on long-term extracorporeal photopheresis.
    Clin Transplant 2017 Jun 27. Epub 2017 Jun 27.
    Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
    Extracorporeal photophoresis (ECP) is an increasingly used therapy to address chronic lung allograft dysfunction (CLAD) following lung transplantation. In 2008, we reported the first single-center experience showing that ECP not only reduces lung function decline in patients with bronchiolitis obliterans syndrome (BOS) but results in stabilization of patients with recurrent acute cellular rejection (ACR). In this study, the original cohort was followed up further 5 years. Read More

    Pediatric cutaneous graft versus host disease: A review.
    Curr Pediatr Rev 2017 Jun 14. Epub 2017 Jun 14.
    Brigham and Women's Hospital, Boston, Massachusetts. United States.
    Background: Graft versus host disease (GVHD) is a significant complication following hematopoietic stem cell transplantation in the pediatric population. The most common clinical manifestation of GVHD is in the skin. This article will present a review of key concepts related to pediatric cutaneous GVHD, including pathophysiology, clinical epidemiology, diagnosis, and treatment options. Read More

    The introduction and evaluation of a pressure ulcer risk assessment tool for photopheresis outpatients.
    Br J Nurs 2017 Jun;26(12 Suppl):S16-S22
    Consultant Haematologist, The Rotherham NHS Foundation Trust.
    Chronic graft-versus-host disease (cGVHD) patients are at high risk of compromised skin integrity, and of developing pressure ulcers, which may bleed and/or become infected. The Rotherham Outpatient Screening Tool (ROST) was adapted from the Waterlow score and the Malnutrition Universial Screening Tool (MUST) to suit patients attending an outpatient unit for photopheresis. A review of the screening tool highlighted patients at a higher risk of developing pressure damage during treatment and therefore the unit was able to reduce this risk by the provision of a pressure-relieving cushion (Repose). Read More

    Comparison of the CELLEX™ and UVAR-XTS™ closed-system extracorporeal photopheresis devices in the treatment of chronic graft-versus-host disease.
    J Clin Apher 2017 Jun 13. Epub 2017 Jun 13.
    Photopheresis Unit, Rotherham NHS Trust, Rotherham, South Yorkshire, United Kingdom.
    Extracorporeal Photopheresis (ECP) is a cellular immunotherapy frequently used for steroid-refractory graft-versus-host disease (GVHD). Chronic GVHD (cGVHD), response to ECP is associated with survival benefit. The UVAR-XTS(TM) system and the more recently developed CELLEX(TM) device (both Therakos(TM) ) are the mainstay for ECP-delivery in the UK and US. Read More

    Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study.
    Leuk Lymphoma 2017 Jun 7:1-9. Epub 2017 Jun 7.
    f Blood Bank Center , Centre Hospitalier Lyon Sud , Pierre Benite , France.
    We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day 21 twice per week during the first two weeks and then once per week for the next four weeks for a total of eight ECP courses. A total of 20 patients were included; 10 were males, median age was 60 years. All patients engrafted, 17 (85%) received the total eight ECP courses. Read More

    Extracorporeal photochemotherapy in mycosis fungoides.
    Transfus Clin Biol 2017 May 31. Epub 2017 May 31.
    Department of Hematology & BMT Unit, School of Medicine, Ankara University, Cebeci Hospital, 06590 Ankara, Turkey.
    Objectives: Extracorporeal photo-chemotherapy (ECP, photopheresis) is an approved treatment modality for mycosis fungoides (MF). Our aim is to present our ECP data for MF.

    Methods: We retrospectively evaluated 50 MF patients who received ECP for clinical activity, toxicity, and response and outcome rates, and we compared these with combination therapies. Read More

    An endpoint associated with clinical benefit after initial treatment of chronic graft-versus-host disease.
    Blood 2017 Jul 11;130(3):360-367. Epub 2017 May 11.
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA.
    No gold standard has been established as a primary endpoint in trials of initial treatment of chronic graft-versus-host disease (GVHD), and evidence showing the association of any proposed primary endpoint with clinical benefit has not been conclusively demonstrated. To address this gap, we analyzed outcomes in a cohort of 328 patients enrolled in a prospective, multicenter, observational study within 3 months after diagnosis of chronic GVHD. Complete and partial response, stable disease, and progressive disease were defined according to the 2014 National Institutes of Health Consensus Development Conference on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease. Read More

    Cessation of extracorporeal photopheresis in chronic lung allograft dysfunction: effects on clinical outcome in adults.
    Swiss Med Wkly 2017 May 10;147:w14429. Epub 2017 May 10.
    Division of Pulmonology, University Hospital Zurich, Switzerland.
    Background: Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, and reimbursement by health insurance providers is a major issue. In Switzerland, ECP is not recognised by the health authorities as a therapy option for CLAD; thus by the end of 2014, ECP had to be stopped in the majority of adult lung transplant recipients cared for at the University Hospital Zurich because of lack of continuous funding. Read More

    Photopheresis: Advances and Use in Systemic Sclerosis.
    Curr Rheumatol Rep 2017 Jun;19(6):31
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    Purpose Of Review: Extracorporeal photochemotherapy (photopheresis, ECP) is a cell-based immunomodulatory treatment that separates leukocytes from peripheral blood, exposes them to a photosensitizing agent followed by ultraviolet A light, and then reinfuses them back into the patient. ECP has been found to be effective for graft versus host disease, transplant rejection, and various autoimmune diseases. The mechanism is not well understood but studies have shown clinical benefit in the treatment of systemic sclerosis (SSc). Read More

    Efficacy of Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome After Lung Transplantation.
    Transplant Proc 2017 May;49(4):695-698
    Department of Thoracic Surgery, Policlinico Umberto I, Sapienza University of Rome, Italy.
    Background: Lung transplantation (LT) is only therapeutic option for patients affected by chronic respiratory failure. Chronic rejection, also known as bronchiolitis obliterans syndrome (BOS), is still the main cause of death and the most important factor that influences post-transplantation quality of life. Currently available therapies have not been proven to result in significant benefit in the prevention or treatment of BOS. Read More

    Impact of plerixafor (mozobil) on hospital efficiency: a single center experience.
    J Clin Apher 2017 Apr 28. Epub 2017 Apr 28.
    Hematology department, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, Paris, 75013, France.
    Plerixafor (Mozobil) in combination with granulocyte colony-stimulating factor (G-CSF) has shown to increase mobilization of peripheral blood stem cells (PBSC) as compared to G-CSF alone in patients undergoing autologous stem cell transplantation (ASCT). However, up to 25% of patients treated with G-CSF alone still fail mobilization. Adding plerixafor to poor mobilizers allows to rescue these patients from mobilization failure and to reduce the number of apheresis sessions. Read More

    Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction.
    J Heart Lung Transplant 2017 Mar 24. Epub 2017 Mar 24.
    Lung Transplant Program, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: Survival after lung transplantation is limited by chronic lung allograft dysfunction (CLAD). Immunomodulatory therapies such as extracorporeal photopheresis (ECP) and alemtuzumab (AL) have been described for refractory CLAD, but comparative outcomes are not well defined.

    Methods: We retrospectively reviewed spirometric values and clinical outcomes after therapy with ECP, AL, or no treatment (NT) in patients with CLAD who underwent transplant between January 2005 and December 2014. Read More

    A transition from using multi-step procedures to a fully integrated system for performing extracorporeal photopheresis: A comparison of costs and efficiencies.
    J Clin Apher 2017 Apr 17. Epub 2017 Apr 17.
    ProcEx Solutions Ltd., Wales, United Kingdom.
    Introduction: The Pitié Salpêtrière Hospital Hemobiotherapy Department, Paris, France, has been providing extracorporeal photopheresis (ECP) since November 2011, and started using the Therakos(®) CELLEX(®) fully integrated system in 2012. This report summarizes our single-center experience of transitioning from the use of multi-step ECP procedures to the fully integrated ECP system, considering the capacity and cost implications.

    Materials And Methods: The total number of ECP procedures performed 2011-2015 was derived from department records. Read More

    Implementation and evaluation of a pre-assessment telephone triage system in an outpatient photopheresis service.
    Br J Nurs 2017 Apr;26(7):400-404
    Consultant Haematologist, The Rotherham NHS Foundation Trust.
    The prompt assessment of patients as fit for photopheresis is imperative to ensure delivery of a safe and efficient service. Before January 2015 the photopheresis unit was reliant on patients contacting the department directly to cancel their appointment if they were unwell or were suffering from any pre-defined exclusion criteria. Methods to reduce the number of cancellations and patients arriving unwell were therefore examined. Read More

    Factual reflections and recommendations on extracorporeal photopheresis in pediatrics.
    Transfus Apher Sci 2017 Apr 22;56(2):118-122. Epub 2017 Mar 22.
    International Consultancy in Blood Components Quality/Safety, Improvement, Audit/Inspection & DDR Strategies, London, UK. Electronic address:
    One of the biggest challenges in evaluating available literature on extracorporeal photopheresis (ECP) practices in pediatric patients is the marked heterogeneity of approaches to the patient evaluation, procedural aspects and apheresis product analysis. These issues are most relevant in ECP management in children with graft versus host disease (GVHD) after hematopoietic stem cell transplantation. Extracorporeal photopheresis in pediatric patients is considered relatively safe with few adverse effects reported from retrospective or observational studies. Read More

    Prospective evaluation of systematic use of peripherally inserted central catheters (PICC lines) for the home care after allogeneic hematopoietic stem cells transplantation.
    Support Care Cancer 2017 Sep 6;25(9):2843-2847. Epub 2017 Apr 6.
    Department of Clinical Hematology, Institut de Cancérologie Lucien Neuwirth, 42171 St, Priest en Jarez, France.
    Purpose: Long-term catheters are often necessary for outpatient care after an allogeneic hematopoietic stem cell transplantation (HSCT), However, there is paucity of data on the use of peripherally inserted central catheter (PICC) in post-HSCT setting.

    Methods: We prospectively evaluated the systematic use of PICC in 37 consecutive patients returning home after HSCT.

    Results: In 6 out of 37 patients, the PICC was exclusively used for weekly blood controls. Read More

    Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation.
    ACG Case Rep J 2017 29;4:e48. Epub 2017 Mar 29.
    Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
    A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Read More

    Treatment of Pediatric Acute Graft-versus-Host Disease-Lessons from Primary Immunodeficiency?
    Front Immunol 2017 21;8:328. Epub 2017 Mar 21.
    Medical School, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
    Allogeneic hematopoietic stem cell transplant (HSCT) is used to treat increasing numbers of malignant and non-malignant disorders. Despite significant advances in improved human leukocyte antigens-typing techniques, less toxic conditioning regimens and better supportive care, resulting in improved clinical outcomes, acute graft-versus-host disease (aGvHD) continues to be a major obstacle and, although it principally involves the skin, gastrointestinal tract, and liver, the thymus is also a primary target. An important aim following HSCT is to achieve complete and durable immunoreconstitution with a diverse T-cell receptor (TCR) repertoire to recognize a broad range of pathogens providing adequate long-term adaptive T-lymphocyte immunity, essential to reduce the risk of infection, disease relapse, and secondary malignancies. Read More

    Apheresis education: One center curriculum design experience.
    Transfus Apher Sci 2017 Apr 22;56(2):263-267. Epub 2017 Mar 22.
    University Health Network, Advanced Practice Nurse Educator, Practice Based Education, Collaborative Academic Practice, Apheresis and Photopheresis; University Health Network, Toronto, Ontario, Canada. Electronic address:
    There is little published in regards to apheresis education and curriculum for nursing. As more importance is placed on education, competency and skills for apheresis through accreditation processes, institutions are left to determine the educational requirements needed for nursing. Working with limited resources, one center has designed a comprehensive apheresis curriculum program that encompasses skills and theory for the novice to experienced learner. Read More

    Extracorporeal photopheresis for the treatment of early-stage mycosis fungoides.
    Dermatol Ther 2017 May 24;30(3). Epub 2017 Mar 24.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1452, Pickens 411, Houston, Texas.
    Extracorporeal photopheresis (ECP) has been used for nearly 30 years in the treatment of cutaneous T-cell lymphoma. However, current clinical practice largely reserves ECP for patients with late-stage mycosis fungoides (MF) or Sézary syndrome or for those who are refractory to other therapies. We briefly describe a 48-year-old male who experienced long-term complete remission of his patch MF disease with ECP, and we suggest a role for ECP in the treatment of early-stage MF given evidence of its efficacy, safety, and tolerability. Read More

    Extracorporeal photopheresis in pediatric patients: Practical and technical considerations.
    J Clin Apher 2017 Mar 17. Epub 2017 Mar 17.
    Department of Pediatrics, Division of Hematology/Oncology/Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    In adults, extracorporeal photopheresis (ECP) is widely utilized for a variety of indications, most commonly cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), solid organ transplant rejection, and other autoimmune and T-cell-mediated disorders. In pediatric patients, the majority of case series and reports have focused on its use in the management of acute and chronic GVHD. Currently utilized ECP technologies were designed for adult patients and there are several challenges in adapting these technologies for use in children. Read More

    Safety and collection efficiency with a lower transfusion threshold for extracorporeal photopheresis in adult patients with graft-versus-host disease.
    Vox Sang 2017 May 7;112(4):379-387. Epub 2017 Mar 7.
    Department of Pathology & Immunology, Washington University, Saint Louis, MO, USA.
    Background: Extracorporeal photopheresis (ECP) is an established treatment for graft-versus-host disease (GVHD). Various haematocrit thresholds have been used to trigger red blood cells transfusion prior to ECP. Moderate-to-severe GVHD is frequently complicated by anaemia; the safety and collection efficiency with a lower haematocrit for ECP is unknown. Read More

    The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society.
    Br J Haematol 2017 Apr 21;177(2):287-310. Epub 2017 Feb 21.
    University Hospitals Birmingham NHS Trust, Birmingham, UK.
    Extracorporeal photopheresis (ECP) has been used for over 35 years in the treatment of erythrodermic cutaneous T-cell lymphoma (CTCL) and over 20 years for chronic and acute graft-versus-host disease (GvHD) and solid organ transplant rejection. ECP for CTCL and GvHD is available at specialised centres across the UK. The lack of prospective randomised trials in ECP led to the development of UK Consensus Statements for patient selection, treatment schedules, monitoring protocols and patient assessment criteria for ECP. Read More

    Extracorporeal photopheresis for bronchiolitis obliterans syndrome after allogeneic stem cell transplant: An emerging therapeutic approach?
    Transfus Apher Sci 2017 Feb 13;56(1):17-19. Epub 2017 Jan 13.
    Immunohaematology and Transfusion Service, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100, Italy. Electronic address:
    Bronchiolitis obliterans syndrome (BOS) is the main manifestation of pulmonary GVHD. It has often a dramatic and fast evolution and current treatment (change or increase in immunosuppression, macrolides and inhaled therapy) is poor with high mortality rates. In this scenario, extracorporeal photopheresis (ECP) bursts as a new immunomodulatory approach with a different philosophical purpose. Read More

    The Italian registry of therapeutic apheresis - 2015.
    Transfus Apher Sci 2017 Feb 29;56(1):75-81. Epub 2016 Dec 29.
    Transfusion Medicine, Department of Padua, University-Hospital of Padua, and Italian Society of Apheresis and Cell Manipulation (SIDEM), Italy. Electronic address:
    Data collection on apheresis activities in Italy throughout 2015 including techniques, clinical indications and adverse effects was performed by means of a SidEM model questionnaire (aggregate data). These data provided by 67 Apheresis Units from 17 Italian regions, albeit rough, are sufficiently informative, mainly in comparison with previous surveys on these statistics. PEx has been the most frequent technique for plasma removal/treatment (11787 procedures) followed by LDL-apheresis (927 procedures). Read More

    Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides.
    J Cutan Pathol 2017 May 10;44(5):462-466. Epub 2017 Feb 10.
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    Loss of CD26 surface expression on the circulating malignant T-cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T-cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T-cells with high CD26 expression. Read More

    A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis.
    Photochem Photobiol Sci 2017 Feb;16(2):193-200
    Institute for Clinical Chemistry and Laboratory Medicine, Transfusion Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
    Background: Extracorporeal photopheresis (ECP) is an efficient method to treat various autoimmune diseases, cutaneous T-cell lymphoma, and graft-versus-host disease. It is based on the ex vivo inactivation of lymphocytes by 8-methoxypsoralen (8-MOP)/UV light treatment. Despite the adhesive, lipophilic nature of 8-MOP, no quality control is established for the ECP procedure. Read More

    Acute mechanical hemolysis as a complication of extracorporeal photopheresis in a low-weight child.
    J Clin Apher 2016 Nov 28. Epub 2016 Nov 28.
    New York-Presbyterian Hospital, New York, New York.
    Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation with high morbidity and mortality. Extracorporeal photopheresis (ECP) is an effective therapy for treating medication-refractory GVHD, however, there is scant evidence of whether ECP can be safely performed in patients weighing less than 15 kg. Here, we report the implementation of a successful protocol to perform ECP in a 21-month-old, 10. Read More

    Extracorporeal Photopheresis for Treatment of Acute and Chronic Graft Versus Host Disease: An Italian Multicentric Retrospective Analysis on 94 Patients on Behalf of the Gruppo Italiano Trapianto di Midollo Osseo.
    Transplantation 2016 Dec;100(12):e147-e155
    1 Hematology, Bone Marrow Transplantation Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy. 2 Immunohematology and Transfusion Medicine Unit, AO Spedali Cvili, Brescia, Italy. 3 SODc Terapia Cellulare e Medicina Trasfusionale, AOU Careggi, Firenze, Italy. 4 Divisione di Ematologia, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy. 5 SC Ematologia, Istituto Nazionale Tumori, Milano, Italy. 6 Clinica Ematologica e Unità di terapie Cellulari, DISM, Università di Udine, Italy. 7 Centro di Ricerca Emato-oncologica AIL (CREA) Brescia, AO Spedali Civili di Brescia, Italy. 8 Unità di Cellule Staminali, Istituto Europeo di Oncologia, Milano, Italy. 9 Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Udine, Italy. 10 UO di Emotrasfusione, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy. 11 Bone Marrow Transplant Unit SODc Ematologia, AOU Careggi, Firenze, Italy.
    Background: Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD).

    Methods: Ninety-four patients with acute GVHD (aGVHD) (n = 45) and chronic GVHD (cGVHD) (n = 49), retrospectively recruited in 6 Italian centers, were submitted to ECP for second-line treatment. At the time of ECP, 22 (49%) and 23 (51%) of 45 patients with aGHVD were nonresponsive and in partial remission (PR) after steroids, respectively, and all the 49 patients with cGVHD were steroid refractory. Read More

    75% Complete Response and 15% Partial Response to Extracorporeal Photopheresis Combined With Other Therapies in Resistant Early Stage Cutaneous T-Cell Lymphoma.
    J Drugs Dermatol 2016 Oct;15(10):1212-1216
    Introduction: Extracorporeal photopheresis (ECP) has been used for the treatment of advanced stage or treatment refractory cutaneous T-cell lymphoma (CTCL) since 1987, and more recently has also been shown to be of benefit for earlier stage resistant CTCL. Complete response rates in prior studies of ECP in early CTCL have ranged from 0% to 40%.

    Methods: We reviewed electronic medical records of all CTCL patients seen in the University of Kansas Cancer Center between June 2007 and May 2011. Read More

    Psoralen and Ultraviolet A Light Treatment Directly Affects Phosphatidylinositol 3-Kinase Signal Transduction by Altering Plasma Membrane Packing.
    J Biol Chem 2016 Nov 29;291(47):24364-24376. Epub 2016 Sep 29.
    From the Transfusion Research Center, Belgian Red Cross-Flanders, 9000 Ghent, Belgium,
    Psoralen and ultraviolet A light (PUVA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft-versus-host disease. DNA damage is well described, but the direct effects of PUVA on cell signal transduction are poorly understood. Because platelets are anucleate and contain archetypal signal transduction machinery, they are ideally suited to address this. Read More

    Cutaneous manifestations of graft-versus-host disease: role of the dermatologist.
    Int J Dermatol 2017 Feb 23;56(2):131-140. Epub 2016 Sep 23.
    Department of Dermatology, Mayo Clinic College of Medicine, Rochester, MN, USA.
    Graft-versus-host disease (GVHD) is the major complication of hematopoietic stem cell transplantation and is associated with high mortality in severe cases. The skin is one of the major organs affected in both acute and chronic GVHD. This review aims to elucidate the basic characteristics of GVHD, and the role and contribution of dermatologists in the care of patients with this condition. Read More

    A retrospective comparative outcome analysis following systemic therapy in Mycosis fungoides and Sezary syndrome.
    Am J Hematol 2016 Dec;91(12):E491-E495
    Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
    Cutaneous T-cell lymphomas (CTCL), with few exceptions, remain incurable and treatment is largely palliative. We performed a retrospective analysis of systemic treatment outcomes of patients diagnosed with MF/SS. We identified 223 patients with MF/SS evaluated at a single institution from 1997 to 2013. Read More


    Improving the service for patients receiving extracorporeal photopheresis using Lean principles.
    Br J Nurs 2016 Sep;25(16):917-21
    Consultant in Photopheresis, The Rotherham NHS Foundation Trust.
    The photopheresis unit where the authors work has seen an increased demand both locally and as an outreach service. A Lean assessment of the unit was undertaken to improve processing time and productivity, which in turn would improve the availability of treatment and improve patient care. The assessment indicated that there were excellent nursing standards and patient care; however, patient waiting times and treatment times were prolonged in comparison with other units. Read More

    Extracorporeal photopheresis did not prevent the development of an autoimmune disease: myasthenia gravis.
    Transfusion 2016 Dec 9;56(12):3081-3085. Epub 2016 Sep 9.
    Pediatric Bone Marrow Transplantation Unit, Medical Park Antalya Hospital, Bahçeşehir University.
    Background: Myasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Read More

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