1,198 results match your criteria Extracorporeal Photopheresis


Feasibility of extracorporeal photopheresis in pediatric patients with graft-versus-host disease after hematopoietic stem cell transplantation.

Pediatr Transplant 2019 Apr 11:e13416. Epub 2019 Apr 11.

The Child and Adolescent Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Graft-versus-host disease (GVHD) is a main cause of morbidity and mortality following hematopoietic stem cell transplantation. The cumulative incidence of acute and chronic GVHD (aGVHD, cGVHD) reaches 30%-50% and 20% in pediatric populations, respectively. Prednisolone and/or calcineurin inhibitors (CNI) are first-line treatments, but no superior second-line treatment has yet been established. Read More

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http://dx.doi.org/10.1111/petr.13416DOI Listing
April 2019
2 Reads

Shaping of CD56 Natural Killer Cells in Patients With Steroid-Refractory/Resistant Acute Graft-vs.-Host Disease via Extracorporeal Photopheresis.

Front Immunol 2019 20;10:547. Epub 2019 Mar 20.

Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.

CD56 natural killer (NK) cells play an important role in the pathogenesis of graft-vs. -host disease (GVHD) and immune defense in the early period after allogeneic hematopoietic stem cell transplantation. Extracorporeal photopheresis (ECP) as an immunomodulating therapy has been widely used for GVHD treatment. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436423PMC
March 2019
2 Reads

Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease.

Blood Adv 2019 Apr;3(7):969-979

Division of Hematologic Malignancies, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; and.

Chronic graft-versus-host disease (cGVHD) affects >50% of hematopoietic stem cell transplant patients. Extracorporeal photopheresis (ECP), an immunomodulatory therapy, provides clinical benefit in steroid-refractory (SR) cGVHD, possibly via regulatory T (T) and natural killer (NK) cell expansion. We demonstrated that low-dose interleukin-2 (IL2) led to clinical improvement in SR-cGVHD and stimulated preferential T and NK-cell expansion with minimal effect on conventional T (T) cells. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457231PMC
April 2019
1 Read

Real-world use of extracorporeal photopheresis for patients with cutaneous T-cell lymphoma in the United States: 2010-2015.

J Dermatolog Treat 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Pharmerit International LP , Bethesda , MA , USA.

Introduction: The National Comprehensive Cancer Network and the European Organization for Research and Treatment of Cancer recommend extracorporeal photopheresis (ECP) as systemic therapy for cutaneous T-cell lymphoma (CTCL).

Objective: To investigate real-world use of ECP in CTCL patients in the US.

Methods: Data from the Truven MarketScan database (2010-2015) were used to create a cohort of CTCL patients receiving systemic treatment. Read More

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http://dx.doi.org/10.1080/09546634.2019.1587144DOI Listing
March 2019
3 Reads

In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis.

J Clin Apher 2019 Mar 12. Epub 2019 Mar 12.

Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Grenoble, France.

Background: Extracorporeal photopheresis (ECP) is an effective therapy for graft vs host disease (GVHD), based on infusion of UVA-irradiated and 8 methoxy-psoralen (PUVA)-treated leukocytes. Reinfusion of these apoptosing cells affects the functionality of pathogenic T cells through poorly understood immunomodulatory mechanisms. Apoptosis is usually a silent, tolerance-associated process, but can also be immunogenic, depending on death-inducers and environmental context. Read More

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http://doi.wiley.com/10.1002/jca.21698
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http://dx.doi.org/10.1002/jca.21698DOI Listing
March 2019
4 Reads

An automated mini buffy coat preparation method for use in mini extracorporeal photopheresis treatment of graft-vs-host-disease in a low body weight pediatric patient.

J Clin Apher 2019 Mar 4. Epub 2019 Mar 4.

Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.

A mini extracorporeal photopheresis (mini-ECP) "off line" technique has been developed for use in the treatment of small children and patients with apheresis contraindications. Until now various methods have been used for buffy coat separation from whole blood. In this report we describe a protocol for mini buffy coat preparation using the automated Sepax laboratory separator for "off line" ECP treatment in a low body weight child with graft-vs-host-disease. Read More

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http://doi.wiley.com/10.1002/jca.21700
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http://dx.doi.org/10.1002/jca.21700DOI Listing
March 2019
7 Reads

Tissue plasminogen activator vs heparin for locking central venous catheters between apheresis procedures.

J Clin Apher 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology, University of Iowa, Iowa City, Iowa.

Background: Central venous catheters (CVCs) for apheresis procedures require regular locking/flushes to maintain adequate flow rates. Literature comparing locking solutions for apheresis, where the time interval between procedures can be longer than for hemodialysis (many days to weeks), is lacking. In this study, catheter malfunction rates using recombinant tissue plasminogen activator (rt-PA) vs heparin for locking CVC between apheresis procedures were compared. Read More

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http://doi.wiley.com/10.1002/jca.21697
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http://dx.doi.org/10.1002/jca.21697DOI Listing
March 2019
5 Reads

A standardized methodical approach to characterize the influence of key parameters on the in vitro efficacy of extracorporeal photopheresis.

PLoS One 2019 1;14(3):e0212835. Epub 2019 Mar 1.

MacoPharma, Biotherapy Division, Rue Lorthiois, Mouvaux, France.

Extracorporeal photopheresis (ECP) is an autologous immunomodulatory cell therapy that consists of the ex vivo collection of mononuclear cells (MNCs), which are irradiated with UVA in the presence of the photosensitizing agent 8-methoxypsoralen (8-MOP) to induce cell apoptosis. This photoactivated cell preparation is then reinfused into the patient. While the clinical benefits of ECP are well-demonstrated, no study has yet characterized the influence of variations in the composition of the cell preparation on the efficacy of ECP in vitro. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212835PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396964PMC
March 2019
1 Read

[Single-center retrospective analysis of extracorporal photopheresis in clinical practice : Peripheral venous compared to central venous access].

Hautarzt 2019 Mar;70(3):193-203

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Deutschland.

Background: Extracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.

Methods: Treatment protocols of 2038 ECP procedures in 52 patients (CTCL, n = 29; GvHD, n = 15; other, n = 8) were evaluated. Read More

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http://link.springer.com/10.1007/s00105-018-4327-y
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http://dx.doi.org/10.1007/s00105-018-4327-yDOI Listing
March 2019
14 Reads

Infusion of Lymphocytes Treated With 8-Methoxypsoralen and Ultraviolet A Light Induces CD19IL-10 Regulatory B Cells and Promotes Skin Allograft Survival.

Transplant Proc 2018 Dec 4;50(10):3906-3910. Epub 2018 May 4.

Organ Transplantation Institute, Beijing Key Laboratory of Organ Transplantation and Immune Regulation, 309th Hospital of the Chinese People's Liberation Army, Beijing, China. Electronic address:

Extracorporeal photopheresis (ECP) represents an alternative to immunosuppression as a means of reducing rejection after thoracic organ transplantation. The mechanism by which ECP exerts its protective effects, until now, has remained elusive. Infusion of ECP-treated splenic lymphocytes (PUVA-SP) can induce CD4CD25Foxp3 regulatory T cells. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.066DOI Listing
December 2018
1 Read

[The long-term infective complications in patients after kidney transplantation and photopheresis].

Urologiia 2018 Dec(5):28-34

The surgical department of transplantation and dialysis of GBUZ Moscow district Moscow Regional Research Clinical Institute named after M.F. Vladimirsky, Moscow, Russia.

Aim: to evaluate the influence of prophylactic use of photopheresis on the risk of long-term infective complications after kidney transplantation.

Materials And Methods: The open cohort randomized study was conducted. A total of 60 recipients after cadaveric kidney allotransplantation from 30 donors were assessed. Read More

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December 2018
1 Read

Mononuclear cell collection for extracorporeal photopheresis by using the "off-line" system: A comparative study between COBE Spectra and Spectra Optia devices.

J Clin Apher 2018 Dec 14. Epub 2018 Dec 14.

Hemathology and Hemotherapy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Extracorporeal photopheresis (ECP) is an efficient and established therapy to treat acute and chronic graft vs host disease (GVHD). Using an "off-line" method, the first step (mononuclear cell [MNC] collection) is decisive, as long as a high MNC yield and purity in the collected product is desirable. Two "off-line" devices were compared: the COBE Spectra and the Spectra Optia (Terumo BCT), using both continuous and intermittent protocols. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21679
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http://dx.doi.org/10.1002/jca.21679DOI Listing
December 2018
5 Reads

New subcutaneous PowerFlow port results in cost and time-savings in a busy outpatient apheresis clinic.

J Clin Apher 2018 Dec 12. Epub 2018 Dec 12.

Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama.

Many vascular access options, such as subcutaneous ports, are currently on the market for use in both medication infusion and for procedures, such as therapeutic plasma exchange and extracorporeal photopheresis. We compared the cost and time necessary to complete apheresis procedures using either Angiodynamic's Vortex or Bard's PowerFlow subcutaneous ports by reviewing our experience on two patients undergoing long-term apheresis treatments with at least 10 procedures with each type of port. We analyzed the cost of needles and thrombolytic therapy, staff time, overall procedure length, and the total time the patient was in the apheresis unit. Read More

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http://dx.doi.org/10.1002/jca.21678DOI Listing
December 2018
4 Reads

A case review of a patient experience of photopheresis using a peripherally inserted central catheter.

J Clin Apher 2019 Feb 10;34(1):73-74. Epub 2018 Nov 10.

Photopheresis, Rotherham Foundation Trust, Rotherham, United Kingdom.

Extracorporeal photopheresis (ECP) is a cell based immunomodulatory therapy in which the patient is attached intravenously to a cell separating machine. During ECP a patient's blood is collected via either a central venous access device (CVAD) or a peripherally inserted 16G arterial venous fistula needle in either one or both antecubital fossa. However, patients presenting for ECP with GVHD repeatedly present a challenge to the ECP team due to poor venous access resulting from previous therapies and skin changes. Read More

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https://onlinelibrary.wiley.com/journal/10981101
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https://onlinelibrary.wiley.com/toc/10981101/0/0
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http://doi.wiley.com/10.1002/jca.21674
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http://dx.doi.org/10.1002/jca.21674DOI Listing
February 2019
22 Reads

Monocytes show immunoregulatory capacity on CD4 T cells in a human in-vitro model of extracorporeal photopheresis.

Clin Exp Immunol 2019 Mar 22;195(3):369-380. Epub 2018 Nov 22.

Tuebingen University Children's Hospital, Department of Hematology and Oncology, Tuebingen, Germany.

Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of action of ECP is not yet fully understood. Knowledge on the fate of CD14 monocytes in the context of ECP is particularly limited and controversial. Read More

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http://doi.wiley.com/10.1111/cei.13232
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http://dx.doi.org/10.1111/cei.13232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378377PMC
March 2019
19 Reads

Favorable impact of extracorporeal photopheresis in acute and chronic graft versus host disease: Prospective single-center study.

J Clin Apher 2018 Dec 5;33(6):654-660. Epub 2018 Nov 5.

Hematology Department and BMT Unit, George Papanicolaou Hospital, Thessaloniki, Greece.

Background: Graft vs host disease (GVHD) is the most severe complication of allogeneic hematopoietic cell transplantation. Conventional immunosuppressive therapy increases morbidity and mortality without improving survival. Extracorporeal photopheresis (ECP) has been introduced as an alternative treatment in steroid-dependent and steroid-refractory disease. Read More

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http://doi.wiley.com/10.1002/jca.21660
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http://dx.doi.org/10.1002/jca.21660DOI Listing
December 2018
12 Reads
1.580 Impact Factor

An alternative for extracorporeal photopheresis: 8-methoxypsoralen and UVA-treated leucocytes from allogeneic donors improve graft-versus-host disease in mice.

Vox Sang 2018 Nov 23;113(8):803-810. Epub 2018 Oct 23.

Department of Transfusion Medicine, University Medical Center Göttingen, Göttingen, Germany.

Background And Objective: Extracorporeal photopheresis (ECP) is an important immune tolerance inducing therapy for graft-versus-host disease (GvHD). However, a sufficient number of ECP cycles cannot be performed in patients with severe GvHD and contraindications for apheresis. Allogeneic sources of leucocytes for use as ECP treatment would be of great benefit. Read More

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http://doi.wiley.com/10.1111/vox.12723
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http://dx.doi.org/10.1111/vox.12723DOI Listing
November 2018
23 Reads

Modulation of B Cells and Homing Marker on NK Cells Through Extracorporeal Photopheresis in Patients With Steroid-Refractory/Resistant Graft-Vs.-Host Disease Without Hampering Anti-viral/Anti-leukemic Effects.

Front Immunol 2018 8;9:2207. Epub 2018 Oct 8.

Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.

Graft-vs.-host disease (GvHD), a severe complication of allogeneic hematopoietic stem cell transplantation, significantly affects the post-transplant morbidity and mortality. Systemic steroids remain the gold standard for the initial management of GvHD. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02207
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http://dx.doi.org/10.3389/fimmu.2018.02207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186805PMC
October 2018
17 Reads

Reducing allogeneic blood exposure in low blood volume extracorporeal photopheresis patients through use of a modified blood prime.

J Clin Apher 2018 Dec 15;33(6):682-684. Epub 2018 Oct 15.

Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, Arizona.

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http://dx.doi.org/10.1002/jca.21661DOI Listing
December 2018
1 Read

The efficacy of extracorporeal photopheresis to arrest bronchiolitis obliterans in lung allograft recipients was compared between two automated photopheresis instruments.

Transfusion 2018 12 12;58(12):2933-2941. Epub 2018 Oct 12.

Department of Pathology & Immunology, Division of Laboratory & Genomic Medicine, Washington University School of Medicine, St Louis, Missouri.

Background: The most common instruments used for extracorporeal photopheresis (ECP) treatment in the United States are the UVAR XTS and the CELLEX devices (Therakos, West Chester, PA). When compared to the UVAR XTS instrument, the efficacy of the CELLEX instrument to arrest the decline in lung function in patients with chronic lung allograft dysfunction (CLAD) related to bronchiolitis obliterans (BOS) has not been previously evaluated.

Methods: The relative efficacy of the CELLEX vs UVAR XTS ECP instruments was assessed by comparing the difference in rates of FEV decline before and after ECP treatment and survival in two series of lung allograft recipients with BOS who had been treated with these instruments. Read More

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http://dx.doi.org/10.1111/trf.14913DOI Listing
December 2018
6 Reads

Mini photopheresis for refractory chronic graft-versus-host disease in children and adolescents.

Transfusion 2018 11 6;58(11):2495-2500. Epub 2018 Oct 6.

Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany.

Background: Extracorporeal photopheresis (ECP) has been established to treat graft-versus-host disease. Our mini ECP technique (mini-ECP) allows for treatment of patients with GVHD and contraindications for classical ECP or low body weight. The safety and efficacy of applying ECP for the long-term treatment of chronic GVHD (cGVHD) have not been described. Read More

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http://dx.doi.org/10.1111/trf.14880DOI Listing
November 2018
27 Reads

A paired trial comparing mononuclear cell collection in two machines for further inactivation through an inline or offline extracorporeal photopheresis procedure.

Transfusion 2019 Jan 4;59(1):340-346. Epub 2018 Oct 4.

Blood Transfusion & Therapeutic Apheresis Unit, Hematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Background: Extracorporeal photopheresis (ECP) is an effective treatment. However, protocols differ widely, and some questions, such as the number of cells to be collected or the number of ECP treatment days per treatment cycle, are still unsolved. The aim of this study was to compare a multistep (offline) (Spectra Optia and Macogenic G2) against an integrated (inline) ECP system (Therakos Cellex system) with respect to mononuclear cell (MNC) collection. Read More

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http://doi.wiley.com/10.1111/trf.14975
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http://dx.doi.org/10.1111/trf.14975DOI Listing
January 2019
12 Reads

An early increase of CD56 natural killer subset as dominant effect and predictor of response to extracorporeal photopheresis for graft-versus-host disease.

Transfusion 2018 12 27;58(12):2924-2932. Epub 2018 Sep 27.

Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain.

Background: CD56 natural killer (NK) regulatory cells were recently shown to display a differential impact on the risk of developing extensive chronic graft-versus-host disease (GVHD). To date no study has definitively established which immune populations are most responsible for the immunomodulatory effects or response to extracorporeal photopheresis (ECP) for GVHD.

Study Design And Methods: To test the role of CD56 NK cells in ECP, a prospective enhanced flow cytometry follow-up of immune subsets (CD19+, CD3+, CD3+/CD4+, CD3+/CD8+, CD3-/CD56+, CD3-/CD56 , and CD3-/CD56 ) was performed in 32 patients with GVHD who underwent 552 procedures. Read More

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http://dx.doi.org/10.1111/trf.14964DOI Listing
December 2018
8 Reads

Effects of extracorporeal photopheresis on serum levels of vitamin D: Preliminary Data from a Pilot Study.

Photodermatol Photoimmunol Photomed 2019 Jan 17;35(1):51-53. Epub 2018 Oct 17.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/phpp.12428DOI Listing
January 2019
4 Reads

Integrating novel systemic therapies for the treatment of mycosis fungoides and Sézary syndrome.

Best Pract Res Clin Haematol 2018 09 18;31(3):322-335. Epub 2018 Jul 18.

City of Hope National Medical Center, Beckman Research Institute, 1500 E. Duarte Road, Duarte, CA 91010, USA. Electronic address:

Novel systemic therapies are generally prescribed to patients with advanced-stage disease or those with early-stage disease refractory to skin-directed therapies. In general, systemic chemotherapy should be reserved for patients who fail to respond to biological agents. Such biological agents include interferon alfa, bexarotene, histone deacetylase inhibitors (vorinostat, romidepsin), brentuximab vedotin and mogamulizumab. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216926183002
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http://dx.doi.org/10.1016/j.beha.2018.07.007DOI Listing
September 2018
9 Reads

Extracorporeal Photopheresis-An Overview.

Front Med (Lausanne) 2018 27;5:236. Epub 2018 Aug 27.

Department of Dermatology, Medizinische Universität Wien, Vienna, Austria.

Extracorporeal photopheresis (ECP) has been in clinical use for over three decades after receiving FDA approval for the palliative treatment of the Sézary Syndrome variant of cutaneous T-cell lymphoma (CTCL) in 1988. After the first positive experiences with CTCL, additional indications have been successfully explored including areas such as graft-vs.-host disease (GVHD), scleroderma, and solid organ transplantation. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2018.00236/
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http://dx.doi.org/10.3389/fmed.2018.00236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119964PMC
August 2018
7 Reads

Pathogen-inactivated blood products for pediatric patients: blood safety, patient safety, or both?

Transfusion 2018 09;58(9):2095-2101

Divisions of Pathology & Laboratory Medicine, Children's National Health System, Washington, DC.

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http://dx.doi.org/10.1111/trf.14811DOI Listing
September 2018
3 Reads

Pericarditis in Patients With Chronic Graft-vs-Host Disease.

Transplant Proc 2018 Sep 14;50(7):2218-2222. Epub 2018 Mar 14.

Department of Hematology, Oncology, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.

Background: There are only a few cases of pericarditis complications following allogeneic bone marrow transplantation described in the literature and there are no data available on the risk and frequency of this condition. The aim of this study was to assess the frequency of exudative pericarditis complicating chronic graft-vs-host disease in allogeneic hematopoietic cell transplant recipients.

Methods: Retrospective analysis involved a group of 105 patients of the Outpatient Transplantation Service of the Department of Hematology, Medical University of Warsaw, who received transplants in the years 2010-2016 and were evaluated for the years 2014-2016. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.130DOI Listing
September 2018
21 Reads

Indication-specific immunomodulatory effects of extracorporeal photopheresis: A pilot study in heart transplanted patients.

J Clin Apher 2018 Oct 3;33(5):591-599. Epub 2018 Sep 3.

Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.

Background: The clinical use of extracorporeal photopheresis (ECP) is based on its ability to induce cell-mediated immune tolerance towards foreign and self-antigens. Up-to-date, no clear consensus consists on how to use ECP after heart transplantation (HTx). In this pilot study, we evaluated the stimulatory effects of ECP on immune cells in HTx patients. Read More

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http://dx.doi.org/10.1002/jca.21647DOI Listing
October 2018
5 Reads

Factors Associated With Mortality and Response to Extracorporeal Photopheresis in Lung Allograft Recipients With Bronchiolitis Obliterans Syndrome.

Transplantation 2018 Aug 20. Epub 2018 Aug 20.

Washington University School of Medicine, Department of Pathology & Immunology, Division of Laboratory & Genomic Medicine, Department of Anesthesiology, Division of Cardiothoracic Anesthesiology.

Background: This study was designed to identify factors associated with clinical response to extracorporeal photopheresis (ECP) and mortality after ECP in lung allograft recipients with bronchiolitis obliterans (BOS).

Methods: FEV1 values obtained 6 months before (baseline) and 6 months after initiation of ECP were used to plot the linear relationship between FEV1 vs time before and after ECP. Response to ECP was assigned when a positive integer was derived after subtracting the baseline rate of decline from the rate of decline 6 months after ECP. Read More

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http://dx.doi.org/10.1097/TP.0000000000002430DOI Listing
August 2018
34 Reads

Diagnosis and treatment of bronchiolitis obliterans syndrome accessible universally.

Bone Marrow Transplant 2019 Mar 23;54(3):383-392. Epub 2018 Jul 23.

Division of Hematology and Stem Cell Transplant, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.

The incidence of bronchiolitis obliterans syndrome (BOS), a devastating manifestation of chronic graft-versus-host-disease, may rise globally due to steady increases in utilization of allogeneic hematopoietic cell transplantation (HCT). Though some advances have occurred in the past decade regarding understanding of the pathogenesis, diagnosis and treatment of BOS, the overall mortality and morbidity remain very high. We sought to determine the current diagnostic and therapeutic challenges, which can potentially hinder optimal management of BOS both in developed and developing countries. Read More

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http://dx.doi.org/10.1038/s41409-018-0266-6DOI Listing
March 2019
45 Reads

Sign of Leser-Trélat and Cutaneous T-Cell Lymphoma: A Rare Association.

Dermatopathology (Basel) 2018 Apr-Jun;5(2):69-73. Epub 2018 May 25.

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

Sign of Leser-Trélat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have been considered controversial and some authors assert the absence of a causal link. Read More

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http://dx.doi.org/10.1159/000488982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031949PMC
May 2018
14 Reads

Treatment of generalized deep morphea and eosinophilic fasciitis with the Janus kinase inhibitor tofacitinib.

JAAD Case Rep 2018 Jun 30;4(5):443-445. Epub 2018 Apr 30.

The Department of Dermatology, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.jdcr.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031588PMC
June 2018
11 Reads

A Prospective Trial of Extracorporeal Photopheresis for Chronic Graft-versus-Host Disease Reveals Significant Disease Response and No Association with Frequency of Regulatory T Cells.

Biol Blood Marrow Transplant 2018 Dec 5;24(12):2373-2380. Epub 2018 Jul 5.

Department of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Extracorporeal photopheresis (ECP) is an accepted treatment for chronic graft-versus-host disease (cGVHD); however, the mechanism of action is unclear. We conducted a prospective multicenter clinical trial to assess ECP response rates using the 2005 National Institutes of Health (NIH) consensus criteria and to assess the relationship between regulatory T cells (Tregs) and treatment response (NCT01324908). Eighty-three patients with any NIH subtype of cGVHD were enrolled, irrespective of number of prior lines of treatment, and 6 were subsequently excluded because of the absence of follow-up from cancer relapse, infection, or study withdrawal. Read More

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http://dx.doi.org/10.1016/j.bbmt.2018.06.035DOI Listing
December 2018
11 Reads

Extracorporeal photopheresis with TC-V in Japanese patients with steroid-resistant chronic graft-versus-host disease.

Int J Hematol 2018 Sep 29;108(3):298-305. Epub 2018 Jun 29.

Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.

There are few established therapies for chronic graft-versus-host disease (cGVHD) refractory to first-line treatment with steroids. We evaluated the efficacy and safety of extracorporeal photopheresis (ECP) with a third-generation TC-V device in Japanese patients with cGVHD. Fifteen patients with steroid-resistant or -intolerant cGVHD after allogeneic hematopoietic stem cell transplantation participated in this multicenter open-label study. Read More

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http://dx.doi.org/10.1007/s12185-018-2483-6DOI Listing
September 2018
8 Reads

Iron Deficiency Anemia in Patients Undergoing Extracorporeal Photopheresis for Cutaneous T-Cell Lymphoma.

Lab Med 2019 Jan;50(1):29-33

Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.

Objective: To describe the indicidence and severity of iron deficiency anemia (IDA) in patients who have received extracorporeal photopheresis (ECP) treatment of cutaneous T-cell lymphoma (CTCL).

Methods: We performed a retrospective study during a 9-year period of patients with CTCL who were treated with ECP. ECP was performed with UVAR XTS and CELLEX (Therakos Inc). Read More

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http://dx.doi.org/10.1093/labmed/lmy034DOI Listing
January 2019
1 Read

A phase II/III randomized, multicenter trial of prednisone/sirolimus prednisone/ sirolimus/calcineurin inhibitor for the treatment of chronic graft--host disease: BMT CTN 0801.

Haematologica 2018 Nov 28;103(11):1915-1924. Epub 2018 Jun 28.

University of Minnesota, Minneapolis, MN.

Initial therapy of chronic graft--host disease is prednisone ± a calcineurin-inhibitor, but most patients respond inadequately. In a randomized, adaptive, phase II/III, multicenter trial we studied whether prednisone/sirolimus or prednisone/sirolimus/photopheresis was more effective than prednisone/sirolimus/calcineurin-inhibitor for treating chronic graft--host disease in treatment-naïve or early inadequate responders. Primary endpoints of this study were proportions of subjects alive without relapse or secondary therapy with 6-month complete or partial response in phase II, or with 2-year complete response in phase III. Read More

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http://dx.doi.org/10.3324/haematol.2018.195123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278959PMC
November 2018
40 Reads

Editor's notes.

Transfus Apher Sci 2018 Jun 9;57(3):421. Epub 2018 May 9.

Department of Transfusion Medicine and Division of Hematology and Stem Cells Transplanation, City of Hope National Cancer Center, Duarte, CA, USA.

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http://dx.doi.org/10.1016/j.transci.2018.05.003DOI Listing
June 2018
7 Reads

Extracorporeal Photopheresis: An Efficacious and Well-Tolerated Treatment for Cutaneous and Oral Mucosal Chronic Graft-versus-Host Disease.

Dermatology 2018 22;234(1-2):23-30. Epub 2018 May 22.

Dermatology Department, University Hospital and Paul Sabatier University of Toulouse, Toulouse, France.

Background: Extracorporeal photopheresis (ECP) is a second-line therapy for steroid-refractory chronic graft-versus-host disease (cGVHD).

Objective: We describe the long-term efficacy and tolerability of ECP according to the cutaneous phenotype of cGVHD and report on the reduced need for immunosuppressant drugs in this setting.

Patients And Methods: Fourteen patients (8 females) with cutaneous and/or mucosal cGVHD, treated with ECP between October 2010 and May 2016 within a single center, were included. Read More

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http://dx.doi.org/10.1159/000488238DOI Listing
January 2019
13 Reads

Photopheresis of a less than 10-kg child with acute graft versus host disease accompanied with hyperbilirubinemia: A case report.

Transfus Apher Sci 2018 Jun 9;57(3):428-430. Epub 2018 May 9.

Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran; Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Tehran, Iran.

Hematopoietic stem cell transplantation is a curative treatment for many hematologic malignancies with its most important side effect being graft-versus-host disease (GVHD). Herein, we present a 3.5 year-old male with weight of 9. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14730502183017
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http://dx.doi.org/10.1016/j.transci.2018.05.006DOI Listing
June 2018
21 Reads
1.070 Impact Factor

Concluding commentary on current trends to enhance the clinical safety of pediatric transfusion, focusing on prevention of untoward complications of HSC transplantation & newer strategies for improving the standards of safety/quality of stem cells expansion for cellular therapy.

Transfus Apher Sci 2018 Jun 16;57(3):378-383. Epub 2018 May 16.

International Consultancy in Blood Components Quality/Safety improvement, Audit/Inspection, and DDR Strategies, London, UK.

Clinical practice and related diagnostic, development and research [DDR] strategies in pediatric transfusion and transplantation cover a broad range of multidisciplinary studies, performed by many professionals involved in this most challenging clinical field [1]. This commentary on the current position and future perspectives in pediatric transfusion field is aimed to highlight major unresolved transfusion complications in pediatric patients, namely red blood cell and platelet alloimmunisation, and new ones such as nosocomial infection, thrombosis and multi-organ failure. Some other safety related issues issues in clinical management of neonates/young infants with urgent medical conditions, requiring immediate transfusion or apheresis treatment, especially, those resulting from hematopoietic stem cell transplantation (HSCT), have been addressed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14730502183019
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http://dx.doi.org/10.1016/j.transci.2018.05.023DOI Listing
June 2018
11 Reads

Sezary syndrome manifesting as posttransplant lymphoproliferative disorder.

Leuk Res Rep 2018 1;9:72-75. Epub 2018 May 1.

Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, USA.

Posttransplant lymphoproliferative disorders (PTLDs) of T-cell orgin are rare biologically heterogeneous diseases of mature lymphoid cells manifesting in immunosuppressed patients. Only a few cases of mycosis fungoides diagnosed post allogeneic hematopoietic cell transplant (alloHSCT) have been described so far. We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Read More

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http://dx.doi.org/10.1016/j.lrr.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948470PMC
May 2018
2 Reads

Acute graft v host disease: developing an extracorporeal photopheresis outreach service.

Br J Nurs 2018 May;27(9):488-492

Consultant Haematologist and Director of Photopheresis Unit, The Rotherham NHS Foundation Trust, Rotherham.

Acute graft v host disease (AGVHD) is the main complication and cause of non-relapse mortality following allogenic hematopoietic stem cell transplantion. It occurs when donor immune cells attack host tissues. The three main organs that AGVHD affects are skin, liver and gastrointestinal tract, with one or more organs being involved. Read More

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http://dx.doi.org/10.12968/bjon.2018.27.9.488DOI Listing
May 2018
20 Reads

Longitudinal follow-up of response status and concomitant immunosuppression in patients treated with extracorporeal photopheresis for chronic graft versus host disease.

Bone Marrow Transplant 2018 May 8. Epub 2018 May 8.

Department of Hematology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, CopenhagenØ, 2100, Denmark.

Improvement in chronic graft vs. host disease (cGvHD) following treatment with extracorporeal photopheresis (ECP) has been shown previously. However, the effect is often measured at only one point in time or as best response. Read More

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http://dx.doi.org/10.1038/s41409-018-0206-5DOI Listing
May 2018
18 Reads

Extracorporeal photopheresis and personalized medicine in the 21st century: The future's so bright!

J Clin Apher 2018 Aug 7;33(4):461-463. Epub 2018 May 7.

Department of Pathology and Laboratory Medicine, Department of Veterans Affairs, White River Junction, Vermont.

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http://dx.doi.org/10.1002/jca.21633DOI Listing
August 2018
41 Reads

Extracorporeal photopheresis in the treatment of acute graft-versus-host disease: a single-center experience.

Transfusion 2018 08 29;58(8):1973-1979. Epub 2018 Apr 29.

Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.

Background: Steroid-refractory acute graft-versus-host disease (aGVHD) is a serious complication after hematopoietic stem cell transplantation. The long-term outcome of the patients is poor. Various immunosuppressive agents have been proposed as the second-line therapy but none of them has turned out more effective than the others. Read More

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http://doi.wiley.com/10.1111/trf.14649
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http://dx.doi.org/10.1111/trf.14649DOI Listing
August 2018
15 Reads

Extracorporeal Photopheresis Improves Survival in Hematopoietic Cell Transplant Patients with Bronchiolitis Obliterans Syndrome without Significantly Impacting Measured Pulmonary Functions.

Biol Blood Marrow Transplant 2018 Sep 18;24(9):1906-1913. Epub 2018 Apr 18.

Division of Hematology, Mayo Clinic, Rochester, Minnesota. Electronic address:

We carried out the first matched retrospective cohort study aimed at studying the safety and efficacy of extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT). Medical records of 1325 consecutive adult patients who underwent HCT between 2005 and 2015 were reviewed. Seventy-four patients (median age, 51 years) with a diagnosis of BOS were included in the study. Read More

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http://dx.doi.org/10.1016/j.bbmt.2018.04.012DOI Listing
September 2018
17 Reads