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    1084 results match your criteria Extracorporeal Photopheresis

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    Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction.
    J Heart Lung Transplant 2017 Mar 24. Epub 2017 Mar 24.
    Lung Transplant Program, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: Survival after lung transplantation is limited by chronic lung allograft dysfunction (CLAD). Immunomodulatory therapies such as extracorporeal photopheresis (ECP) and alemtuzumab (AL) have been described for refractory CLAD, but comparative outcomes are not well defined.

    Methods: We retrospectively reviewed spirometric values and clinical outcomes after therapy with ECP, AL, or no treatment (NT) in patients with CLAD who underwent transplant between January 2005 and December 2014. Read More

    A transition from using multi-step procedures to a fully integrated system for performing extracorporeal photopheresis: A comparison of costs and efficiencies.
    J Clin Apher 2017 Apr 17. Epub 2017 Apr 17.
    ProcEx Solutions Ltd., Wales, United Kingdom.
    Introduction: The Pitié Salpêtrière Hospital Hemobiotherapy Department, Paris, France, has been providing extracorporeal photopheresis (ECP) since November 2011, and started using the Therakos(®) CELLEX(®) fully integrated system in 2012. This report summarizes our single-center experience of transitioning from the use of multi-step ECP procedures to the fully integrated ECP system, considering the capacity and cost implications.

    Materials And Methods: The total number of ECP procedures performed 2011-2015 was derived from department records. Read More

    Implementation and evaluation of a pre-assessment telephone triage system in an outpatient photopheresis service.
    Br J Nurs 2017 Apr;26(7):400-404
    Consultant Haematologist, The Rotherham NHS Foundation Trust.
    The prompt assessment of patients as fit for photopheresis is imperative to ensure delivery of a safe and efficient service. Before January 2015 the photopheresis unit was reliant on patients contacting the department directly to cancel their appointment if they were unwell or were suffering from any pre-defined exclusion criteria. Methods to reduce the number of cancellations and patients arriving unwell were therefore examined. Read More

    Factual reflections and recommendations on extracorporeal photopheresis in pediatrics.
    Transfus Apher Sci 2017 Mar 22. Epub 2017 Mar 22.
    International Consultancy in Blood Components Quality/Safety, Improvement, Audit/Inspection & DDR Strategies, London, UK. Electronic address:
    One of the biggest challenges in evaluating available literature on extracorporeal photopheresis (ECP) practices in pediatric patients is the marked heterogeneity of approaches to the patient evaluation, procedural aspects and apheresis product analysis. These issues are most relevant in ECP management in children with graft versus host disease (GVHD) after hematopoietic stem cell transplantation. Extracorporeal photopheresis in pediatric patients is considered relatively safe with few adverse effects reported from retrospective or observational studies. Read More

    Prospective evaluation of systematic use of peripherally inserted central catheters (PICC lines) for the home care after allogeneic hematopoietic stem cells transplantation.
    Support Care Cancer 2017 Apr 6. Epub 2017 Apr 6.
    Department of Clinical Hematology, Institut de Cancérologie Lucien Neuwirth, 42171 St, Priest en Jarez, France.
    Purpose: Long-term catheters are often necessary for outpatient care after an allogeneic hematopoietic stem cell transplantation (HSCT), However, there is paucity of data on the use of peripherally inserted central catheter (PICC) in post-HSCT setting.

    Methods: We prospectively evaluated the systematic use of PICC in 37 consecutive patients returning home after HSCT.

    Results: In 6 out of 37 patients, the PICC was exclusively used for weekly blood controls. Read More

    Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation.
    ACG Case Rep J 2017 29;4:e48. Epub 2017 Mar 29.
    Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
    A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Read More

    Treatment of Pediatric Acute Graft-versus-Host Disease-Lessons from Primary Immunodeficiency?
    Front Immunol 2017 21;8:328. Epub 2017 Mar 21.
    Medical School, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
    Allogeneic hematopoietic stem cell transplant (HSCT) is used to treat increasing numbers of malignant and non-malignant disorders. Despite significant advances in improved human leukocyte antigens-typing techniques, less toxic conditioning regimens and better supportive care, resulting in improved clinical outcomes, acute graft-versus-host disease (aGvHD) continues to be a major obstacle and, although it principally involves the skin, gastrointestinal tract, and liver, the thymus is also a primary target. An important aim following HSCT is to achieve complete and durable immunoreconstitution with a diverse T-cell receptor (TCR) repertoire to recognize a broad range of pathogens providing adequate long-term adaptive T-lymphocyte immunity, essential to reduce the risk of infection, disease relapse, and secondary malignancies. Read More

    Apheresis education: One center curriculum design experience.
    Transfus Apher Sci 2017 Mar 22. Epub 2017 Mar 22.
    University Health Network, Advanced Practice Nurse Educator, Practice Based Education, Collaborative Academic Practice, Apheresis and Photopheresis; University Health Network, Toronto, Ontario, Canada. Electronic address:
    There is little published in regards to apheresis education and curriculum for nursing. As more importance is placed on education, competency and skills for apheresis through accreditation processes, institutions are left to determine the educational requirements needed for nursing. Working with limited resources, one center has designed a comprehensive apheresis curriculum program that encompasses skills and theory for the novice to experienced learner. Read More

    Extracorporeal photopheresis for the treatment of early-stage mycosis fungoides.
    Dermatol Ther 2017 Mar 24. Epub 2017 Mar 24.
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1452, Pickens 411, Houston, Texas.
    Extracorporeal photopheresis (ECP) has been used for nearly 30 years in the treatment of cutaneous T-cell lymphoma. However, current clinical practice largely reserves ECP for patients with late-stage mycosis fungoides (MF) or Sézary syndrome or for those who are refractory to other therapies. We briefly describe a 48-year-old male who experienced long-term complete remission of his patch MF disease with ECP, and we suggest a role for ECP in the treatment of early-stage MF given evidence of its efficacy, safety, and tolerability. Read More

    Extracorporeal photopheresis in pediatric patients: Practical and technical considerations.
    J Clin Apher 2017 Mar 17. Epub 2017 Mar 17.
    Department of Pediatrics, Division of Hematology/Oncology/Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    In adults, extracorporeal photopheresis (ECP) is widely utilized for a variety of indications, most commonly cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), solid organ transplant rejection, and other autoimmune and T-cell-mediated disorders. In pediatric patients, the majority of case series and reports have focused on its use in the management of acute and chronic GVHD. Currently utilized ECP technologies were designed for adult patients and there are several challenges in adapting these technologies for use in children. Read More

    Safety and collection efficiency with a lower transfusion threshold for extracorporeal photopheresis in adult patients with graft-versus-host disease.
    Vox Sang 2017 Mar 7. Epub 2017 Mar 7.
    Department of Pathology & Immunology, Washington University, Saint Louis, MO, USA.
    Background: Extracorporeal photopheresis (ECP) is an established treatment for graft-versus-host disease (GVHD). Various haematocrit thresholds have been used to trigger red blood cells transfusion prior to ECP. Moderate-to-severe GVHD is frequently complicated by anaemia; the safety and collection efficiency with a lower haematocrit for ECP is unknown. Read More

    The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society.
    Br J Haematol 2017 Apr 21;177(2):287-310. Epub 2017 Feb 21.
    University Hospitals Birmingham NHS Trust, Birmingham, UK.
    Extracorporeal photopheresis (ECP) has been used for over 35 years in the treatment of erythrodermic cutaneous T-cell lymphoma (CTCL) and over 20 years for chronic and acute graft-versus-host disease (GvHD) and solid organ transplant rejection. ECP for CTCL and GvHD is available at specialised centres across the UK. The lack of prospective randomised trials in ECP led to the development of UK Consensus Statements for patient selection, treatment schedules, monitoring protocols and patient assessment criteria for ECP. Read More

    Extracorporeal photopheresis for bronchiolitis obliterans syndrome after allogeneic stem cell transplant: An emerging therapeutic approach?
    Transfus Apher Sci 2017 Feb 13;56(1):17-19. Epub 2017 Jan 13.
    Immunohaematology and Transfusion Service, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100, Italy. Electronic address:
    Bronchiolitis obliterans syndrome (BOS) is the main manifestation of pulmonary GVHD. It has often a dramatic and fast evolution and current treatment (change or increase in immunosuppression, macrolides and inhaled therapy) is poor with high mortality rates. In this scenario, extracorporeal photopheresis (ECP) bursts as a new immunomodulatory approach with a different philosophical purpose. Read More

    The Italian registry of therapeutic apheresis - 2015.
    Transfus Apher Sci 2017 Feb 29;56(1):75-81. Epub 2016 Dec 29.
    Transfusion Medicine, Department of Padua, University-Hospital of Padua, and Italian Society of Apheresis and Cell Manipulation (SIDEM), Italy. Electronic address:
    Data collection on apheresis activities in Italy throughout 2015 including techniques, clinical indications and adverse effects was performed by means of a SidEM model questionnaire (aggregate data). These data provided by 67 Apheresis Units from 17 Italian regions, albeit rough, are sufficiently informative, mainly in comparison with previous surveys on these statistics. PEx has been the most frequent technique for plasma removal/treatment (11787 procedures) followed by LDL-apheresis (927 procedures). Read More

    Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides.
    J Cutan Pathol 2017 May 10;44(5):462-466. Epub 2017 Feb 10.
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    Loss of CD26 surface expression on the circulating malignant T-cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T-cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T-cells with high CD26 expression. Read More

    A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis.
    Photochem Photobiol Sci 2017 Feb;16(2):193-200
    Institute for Clinical Chemistry and Laboratory Medicine, Transfusion Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
    Background: Extracorporeal photopheresis (ECP) is an efficient method to treat various autoimmune diseases, cutaneous T-cell lymphoma, and graft-versus-host disease. It is based on the ex vivo inactivation of lymphocytes by 8-methoxypsoralen (8-MOP)/UV light treatment. Despite the adhesive, lipophilic nature of 8-MOP, no quality control is established for the ECP procedure. Read More

    Acute mechanical hemolysis as a complication of extracorporeal photopheresis in a low-weight child.
    J Clin Apher 2016 Nov 28. Epub 2016 Nov 28.
    New York-Presbyterian Hospital, New York, New York.
    Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation with high morbidity and mortality. Extracorporeal photopheresis (ECP) is an effective therapy for treating medication-refractory GVHD, however, there is scant evidence of whether ECP can be safely performed in patients weighing less than 15 kg. Here, we report the implementation of a successful protocol to perform ECP in a 21-month-old, 10. Read More

    Extracorporeal Photopheresis for Treatment of Acute and Chronic Graft Versus Host Disease: An Italian Multicentric Retrospective Analysis on 94 Patients on Behalf of the Gruppo Italiano Trapianto di Midollo Osseo.
    Transplantation 2016 Dec;100(12):e147-e155
    1 Hematology, Bone Marrow Transplantation Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy. 2 Immunohematology and Transfusion Medicine Unit, AO Spedali Cvili, Brescia, Italy. 3 SODc Terapia Cellulare e Medicina Trasfusionale, AOU Careggi, Firenze, Italy. 4 Divisione di Ematologia, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy. 5 SC Ematologia, Istituto Nazionale Tumori, Milano, Italy. 6 Clinica Ematologica e Unità di terapie Cellulari, DISM, Università di Udine, Italy. 7 Centro di Ricerca Emato-oncologica AIL (CREA) Brescia, AO Spedali Civili di Brescia, Italy. 8 Unità di Cellule Staminali, Istituto Europeo di Oncologia, Milano, Italy. 9 Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Udine, Italy. 10 UO di Emotrasfusione, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy. 11 Bone Marrow Transplant Unit SODc Ematologia, AOU Careggi, Firenze, Italy.
    Background: Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD).

    Methods: Ninety-four patients with acute GVHD (aGVHD) (n = 45) and chronic GVHD (cGVHD) (n = 49), retrospectively recruited in 6 Italian centers, were submitted to ECP for second-line treatment. At the time of ECP, 22 (49%) and 23 (51%) of 45 patients with aGHVD were nonresponsive and in partial remission (PR) after steroids, respectively, and all the 49 patients with cGVHD were steroid refractory. Read More

    75% Complete Response and 15% Partial Response to Extracorporeal Photopheresis Combined With Other Therapies in Resistant Early Stage Cutaneous T-Cell Lymphoma.
    J Drugs Dermatol 2016 Oct;15(10):1212-1216
    Introduction: Extracorporeal photopheresis (ECP) has been used for the treatment of advanced stage or treatment refractory cutaneous T-cell lymphoma (CTCL) since 1987, and more recently has also been shown to be of benefit for earlier stage resistant CTCL. Complete response rates in prior studies of ECP in early CTCL have ranged from 0% to 40%.

    Methods: We reviewed electronic medical records of all CTCL patients seen in the University of Kansas Cancer Center between June 2007 and May 2011. Read More

    Psoralen and Ultraviolet A Light Treatment Directly Affects Phosphatidylinositol 3-Kinase Signal Transduction by Altering Plasma Membrane Packing.
    J Biol Chem 2016 Nov 29;291(47):24364-24376. Epub 2016 Sep 29.
    From the Transfusion Research Center, Belgian Red Cross-Flanders, 9000 Ghent, Belgium,
    Psoralen and ultraviolet A light (PUVA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft-versus-host disease. DNA damage is well described, but the direct effects of PUVA on cell signal transduction are poorly understood. Because platelets are anucleate and contain archetypal signal transduction machinery, they are ideally suited to address this. Read More


    Improving the service for patients receiving extracorporeal photopheresis using Lean principles.
    Br J Nurs 2016 Sep;25(16):917-21
    Consultant in Photopheresis, The Rotherham NHS Foundation Trust.
    The photopheresis unit where the authors work has seen an increased demand both locally and as an outreach service. A Lean assessment of the unit was undertaken to improve processing time and productivity, which in turn would improve the availability of treatment and improve patient care. The assessment indicated that there were excellent nursing standards and patient care; however, patient waiting times and treatment times were prolonged in comparison with other units. Read More

    Extracorporeal photopheresis did not prevent the development of an autoimmune disease: myasthenia gravis.
    Transfusion 2016 Dec 9;56(12):3081-3085. Epub 2016 Sep 9.
    Pediatric Bone Marrow Transplantation Unit, Medical Park Antalya Hospital, Bahçeşehir University.
    Background: Myasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Read More

    EXTRACORPOREAL PHOTOPHERESIS (ECP) FOR TREATEMENT OF ACUTE AND CHRONIC GRAFT VERSUS HOST DISEASE: AN ITALIAN MULTICENTRIC RETROSPECTIVE ANALYSIS ON 94 PATIENTS ON BEHALF OF THE GRUPPO ITALIANO TRAPIANTO DI MIDOLLO OSSEO (GITMO).
    Transplantation 2016 Sep 8. Epub 2016 Sep 8.
    1 Chair of Hematology, Bone Marrow Transplantation Unit, Dept of Clincial and Experimental Sciences, University of Brescia, Italy 2 Immunohematology and Transfusion Medicine Unit, AO Spedali Cvili, Brescia, Italy 3 SODc Terapia Cellulare e Medicina Trasfusionale, AOU Careggi, Firenze, Italy 4 Divisione di Ematologia, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy 5 SC Ematologia, Istituto Nazionale Tumori, Milano, Italy 6 Clinica Ematologica e Unità di terapie Cellulari, DISM, Università di Udine, Italy 7 Centro di Ricerca Emato-oncologica AIL (CREA) Brescia, AO Spedali Civili di Brescia, Italy 8 Unità di Cellule Staminali, Istituto Europeo di Oncologia, Milano, Italy 9 Medicina Trasfusionale, Azienda Ospedaliero-Universitaria di Udine, Italy 10 UO di Emotrasfusione, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy 11 Bone Marrow Transplant Unit SODc Ematologia, AOU Careggi, Firenze, Italy.
    Background: Extracorporeal photopheresis (ECP) is considered a valid second-line treatment for acute and chronic graft versus host disease (GVHD).

    Methods: Ninety-four patients with aGVHD (n=45) and cGVHD (n=49), retrospectively recruited in 6 Italian Centers, were submitted to ECP for second-line treatment. At the time of ECP, 22 (49%) and 23 (51%) out of 45 patients with aGHVD were non responsive (NR) and in partial remission (PR) after steroids, respectively, and all the 49 patients with cGVHD were steroid refractory. Read More

    X-Ray Psoralen Activated Cancer Therapy (X-PACT).
    PLoS One 2016 1;11(9):e0162078. Epub 2016 Sep 1.
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.
    This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative disease and extracorporeal photopheresis (ECP) of cutaneous T Cell Lymphoma. An immunogenic role for light-activated psoralen has been reported, contributing to long-term clinical responses. Read More

    Phototherapy in Scleroderma.
    Dermatol Ther (Heidelb) 2016 Dec 12;6(4):519-553. Epub 2016 Aug 12.
    Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
    Systemic and localized scleroderma are difficult to manage diseases with no accepted gold standard of therapy to date. Phototherapeutic modalities for scleroderma show promise. A PubMed search of information on phototherapy for scleroderma was conducted. Read More

    [Pansclerotic morphea with a rapidly fatal outcome in an 11-year-old girl].
    Ann Dermatol Venereol 2016 Dec 2;143(12):836-840. Epub 2016 Aug 2.
    Service de dermatologie, CHU Larrey-Toulouse, 24, chemin de Pouvourville, 31400 Toulouse, France.
    Background: Pansclerotic morphea is a poorly described but extremely debilitating variant of localized scleroderma. We report a case with a rapidly fatal outcome in an 11-year-old girl.

    Patients And Methods: An 11-year-old girl with a 2-year history of morphea presented at our institution in April 2012. Read More

    Extracorporeal photopheresis as an immunomodulatory agent: Haematocrit-dependent effects on natural killer cells.
    J Clin Apher 2016 Jul 31. Epub 2016 Jul 31.
    Department of Oncohematology, Cell Therapy Laboratory, Azienda Ospedaliero Universitaria Meyer, AOU Meyer, Florence, Italy.
    The GvHD is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal photopheresis (ECP) represents an alternative therapeutic strategy to immunosuppressive therapy. Although ECP is used since 1990s, the mechanism of action has not yet been completely clarified. Read More

    Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports.
    J Med Case Rep 2016 Jul 28;10:209. Epub 2016 Jul 28.
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, USA.
    Background: Patients who undergo allogeneic stem cell transplantation and subsequent radiation therapy uncommonly develop graft-versus-host disease within the irradiated area. We quantified the incidence of this complication, which is a novel contribution to the field. From 2010 to 2014, 1849 patients underwent allogeneic stem cell transplantation, and 41 (2 %) received radiation therapy afterward. Read More

    Technical comparison of four different extracorporeal photopheresis systems.
    Transfusion 2016 Oct 26;56(10):2510-2519. Epub 2016 Jul 26.
    Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
    Background: Extracorporeal photopheresis (ECP) is a therapeutic technique that combines leukapheresis and ultraviolet (UV)A irradiation of the leukapheresate after 8-methoxypsoralen treatment with subsequent retransfusion. It can be achieved with a single device (online) or by combining an apheresis machine with a separate UVA light source (offline). The comparability of both established methods is unknown. Read More

    Extracorporeal photopheresis practice patterns: An international survey by the ASFA ECP subcommittee.
    J Clin Apher 2016 Jul 21. Epub 2016 Jul 21.
    Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital, Chicago, IL.
    Background: Although many apheresis centers offer extracorporeal photopheresis (ECP), little is known about current treatment practices.

    Methods: An electronic survey was distributed to assess ECP practice internationally.

    Results: Of 251 responses, 137 met criteria for analysis. Read More

    Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review.
    An Bras Dermatol 2016 May-Jun;91(3):336-43
    "Dr. José E. Gonzalez" University Hospital of the ''Universidad Autonoma de Nuevo León'' Medical School - Nuevo León, Mexico.
    Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous graft-versus-host disease. Read More

    Treatment of necrobiotic xanthogranuloma - a systematic review.
    J Eur Acad Dermatol Venereol 2017 Feb 19;31(2):221-235. Epub 2016 Jul 19.
    Department of Dermatology, University Hospital, Jena, Germany.
    Necrobiotic xanthogranuloma (NXG) is an uncommon non-Langerhans cell histiocytosis involving skin and extracutaneous tissues. The lesions are usually asymptomatic and commonly appear in the periorbital area. Paraproteinemia is closely associated with NXG and its pathogenesis remains unclear. Read More

    Extracoporeal photopheresis treatment of acute graft-versus-host disease following allogeneic haematopoietic stem cell transplantation.
    F1000Res 2016 27;5. Epub 2016 Jun 27.
    Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Paediatric Haematopoietic Stem Cell Unit, Great North Children's Hospital, Newcastle upon Tyne, UK.
    Acute graft-versus-host disease (aGvHD) continues to be a major obstacle to allogeneic haematopoietic stem cell transplantation. Thymic damage secondary to aGvHD along with corticosteroids and other non-selective T lymphocyte-suppressive agents used in the treatment of aGvHD concurrently impair thymopoiesis and negatively impact on immunoreconstitution of the adaptive immune compartment and ultimately adversely affect clinical outcome. Extracorporeal photopheresis (ECP) is an alternative therapeutic strategy that appears to act in an immunomodulatory fashion, potentially involving regulatory T lymphocytes and dendritic cells. Read More

    Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach from the Writing Committee of the American Society for Apheresis: The Seventh Special Issue.
    J Clin Apher 2016 Jun;31(3):149-62
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
    The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA) Special Issue Writing Committee is charged with reviewing, updating, and categorizing indications for the evidence-based use of therapeutic apheresis in human disease. Since the 2007 JCA Special Issue (Fourth Edition), the Committee has incorporated systematic review and evidence-based approaches in the grading and categorization of apheresis indications. This Seventh Edition of the JCA Special Issue continues to maintain this methodology and rigor to make recommendations on the use of apheresis in a wide variety of diseases/conditions. Read More

    Induction of anti-tumor CD8 T cell responses by experimental ECP-induced human dendritic antigen presenting cells.
    Transfus Apher Sci 2016 Aug 6;55(1):146-52. Epub 2016 Jun 6.
    Department of Dermatology, Yale University, New Haven, CT 06520. Electronic address:
    Extracorporeal photochemotherapy (ECP), or photopheresis, is distinguished by the specificity of the clinically potent immunologic reactions it initiates or regulates. The selectivity of ECP-induced immunoprotection for the malignant clone in cutaneous T cell lymphoma (CTCL), and for the pathogenic clones in allograft rejection and graft-versus-host disease (GVHD), has suggested a central mechanistic role for dendritic antigen presenting cells (DC). Discovery of ECP's induction of monocyte-derived DC, via monocyte signaling by ECP-plate activated platelets, and the absolute dependency of experimental ECP on such induced DC, supports that premise. Read More

    Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers.
    Bioorg Med Chem 2016 Sep 2;24(17):3918-31. Epub 2016 Jun 2.
    Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States. Electronic address:
    Extracorporeal photopheresis (ECP) has been used successfully in the treatment of erythrodermic cutaneous T cell lymphoma (CTCL), and other T cell-mediated disorders. Not all patients obtain a significant or durable response from ECP. The design of a selective photosensitizer that spares desirable lymphocytes while targeting malignant T cells may promote cytotoxic T cell responses and improve outcomes after ECP. Read More

    Comparison of two automated mononuclear cell collection systems in patients undergoing extracorporeal photopheresis: a prospective crossover equivalence study.
    Transfusion 2016 Aug 1;56(8):2078-84. Epub 2016 Jun 1.
    Immunohaematology and Transfusion Service, Apheresis and Cell Therapy Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    Background: Extracorporeal photopheresis (ECP) is an effective cell therapy employed in several diseases, including graft versus host disease (GVHD) and organ rejection. When ECP is performed using an off-line technique, mononuclear cell (MNC) collection by leukapheresis is necessary for further manipulation (addition of 8-methoxypsoralen and ultraviolet A irradiation before reinfusion to the patient). We report the results of the first crossover equivalence study on yield and purity of MNCs collected from patients undergoing ECP with two different automated systems: MNC and CMNC (working with intermittent and continuous-flow collection, respectively), released by Terumo BCT. Read More

    Graft-versus-host disease in paediatric solid organ transplantation: A review of the literature.
    Pediatr Transplant 2016 Aug 19;20(5):607-18. Epub 2016 May 19.
    King's College Hospital - Paediatric Liver, GI and Nutrition Centre, London, UK.
    GvHD is a rare and serious complication of organ transplantation. The literature is sparse following solid organ transplantation. The aim of this report was to review the literature of GvHD in paediatric solid organ transplantation. Read More

    How I treat mycosis fungoides and Sézary syndrome.
    Blood 2016 Jun 5;127(25):3142-53. Epub 2016 May 5.
    Division of Cancer Medicine, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, VIC, Australia.
    Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma variant and is closely related to a rare leukemic variant, Sézary syndrome (SS). MF patients at risk of disease progression can now be identified and an international consortium has been established to address the prognostic relevance of specific biologic factors and define a prognostic index. There are a lack of randomized clinical trial data in MF/SS and evidence is based on a traditional "stage-based" approach; treatment of early-stage disease (IA-IIA) involves skin directed therapies which include topical corticosteroids, phototherapy (psoralen with UVA or UVB), topical chemotherapy, topical bexarotene, and radiotherapy including total skin electron beam therapy. Read More

    Regulatory T Cells in Chronic Graft-Versus-Host Disease After Extracorporeal Photopheresis: Correlation With Skin and Global Organ Responses, and Ability to Taper Steroids.
    Transplantation 2017 Jan;101(1):204-211
    1 Haematology Department and Photopheresis Unit, Rotherham NHS Foundation Trust, Rotherham, South Yorkshire, United Kingdom. 2 Medical Statistics Group, School of Health and Related Research (ScHARR), The University of Sheffield Sheffield, South Yorkshire, United Kingdom. 3 Knowledge and Intelligence Team (East Midlands), Public Health England, Sheffield, United Kingdom.
    Background: Induction of immune tolerance by an increase in regulatory T (Treg) cells after extracorporeal photopheresis (ECP) is thought to contribute to how ECP exerts its therapeutic effect in patients with chronic graft-versus-host disease (cGvHD). We investigated whether percentages and absolute counts of Treg cells changed post-ECP, and examined correlation with response.

    Methods: Absolute counts and % of CD4+ T cells and Treg cells (CD4 + CD25 + FOXP3 + CD127dim/-) were evaluated using flow cytometry in 32 patients with cGvHD treated by ECP for a minimum of 3 months, and up to 12 months. Read More

    Extracorporeal Photopheresis for Non-skin GvHD.
    Anticancer Res 2016 Mar;36(3):1395-6
    Department of Dermatology, Saarland University Hospital, Homburg, Germany.
    Graft versus host disease (GvHD) is one of the most feared adverse events of allogeneic hematopoietic stem cell transplantation. In severe grades of GvHD patients die from infections due to impairment of their immune defense or therapy-refractory involvement of intestines, liver and lung. Extracorporeal photopheresis is an effective treatment for acute and chronic graft versus host disease without severe impairment of the recipient's immune system. Read More

    An alternative mini buffy coat preparation method for adult patients with extracorporeal photopheresis contraindications.
    J Clin Apher 2017 Feb 4;32(1):12-15. Epub 2016 Mar 4.
    Department for Blood Group Serology and Transfusion Medicine, SALK - Paracelsus Medical University (PMU), Salzburg, Austria.
    Background: Extracorporeal photopheresis (ECP) is an important cell-based therapy for various diseases but is limited to patients eligible for apheresis. We developed an alternative mini buffy coat (BC) preparation method using the Spectra Optia® apheresis system and compared its efficacy of white blood cell (WBC) recovery with the standard mini BC preparation method already established for pediatric patients.

    Methods: Whole blood (450 ± 45 mL) samples were collected from 30 randomly selected healthy volunteer blood donors and divided into two groups. Read More

    Ultraviolet blood irradiation: Is it time to remember "the cure that time forgot"?
    J Photochem Photobiol B 2016 Apr 5;157:89-96. Epub 2016 Feb 5.
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address:
    Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma, and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However, with the development of antibiotics, the use of UBI declined and it has now been called "the cure that time forgot. Read More

    Extracorporeal photopheresis in solid organ transplant-associated acute graft-versus-host disease.
    Transfusion 2016 Apr 18;56(4):962-9. Epub 2016 Feb 18.
    Department of Medicine.
    Background: Extracorporeal photopheresis (ECP) culls pathogenic T lymphocytes, be these the clones of cutaneous T-cell lymphoma, or mediators of chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT-GVHD). Whether or not ECP may have an effect in the rarer instances of solid organ transplantation-associated GVHD (SOT-GVHD) is unclear. Mortality rates in SOT-GVHD rival those of transfusion-associated GVHD, with fatalities preceded by pancytopenia and peripheral blood chimerism (PBC) levels exceeding 20%. Read More

    Pharmacological- and non-pharmacological therapeutic approaches in inflammatory bowel disease in adults.
    World J Gastrointest Pharmacol Ther 2016 Feb;7(1):5-20
    Gerda C Leitner, University Clinic for Blood Group Serology and Transfusion Medicine, Medical University, 1090 Vienna, Austria.
    Inflammatory bowel diseases (IBDs) are a group of chronic inflammatory conditions mainly of the colon and small intestine. Crohn's disease (CD) and ulcerative colitis (UC) are the most frequent types of IBD. IBD is a complex disease which arises as a result of the interaction of environmental, genetic and immunological factors. Read More

    [THE DYNAMICS OF IMMUNOLOGICAL RESULTS OF PATIENTS WITH T-CELL SKIN LYMPHOMAS AND PSORIASIS BY THE THERAPY OF ACTIVATION MECHANISMS SANOGENESIS METHODS].
    Lik Sprava 2015 Apr-Jun(3-4):31-8
    The therapy T-cell skin lymphoma and psoriasis by the application of activation mechanisms sanogenesis methods, such as: original--a treatment plasmapheresis, a standard heparin infusion; used for the first time--wobenzym; solutions of acid acetic food and sodium bicarbonate; known--the basic sanitations of concomitant diseases, photopheresis caused remissions in 79.6% patients with different stages T-cell skin lymphoma (observed over an 8-year span), and in 67% of patients with psoriasis (observed over an 6-year span). Depuration reactions (phagocytosis, pinocytosis, toxin neutralization) has been activated by detoxication of treatment plasmapheresis and heparin infusions. Read More

    Establishing an institutional therapeutic apheresis registry.
    J Clin Apher 2016 Dec 23;31(6):516-522. Epub 2016 Jan 23.
    Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, Arizona.
    Apheresis was first performed as a therapeutic procedure in the 1950s. The first national therapeutic apheresis (TA) registry was established in Canada in 1981 and other national registries followed, including two attempts at establishing an international TA registry. There is no national registry in the United States. Read More

    [Chronic rejection: Differences and similarities in various solid organ transplants].
    Internist (Berl) 2016 Jan;57(1):25-37
    Institut für Pathologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
    In this paper, chronic rejections after transplantation of the lungs, heart, liver, and kidney are described. Chronic allograft dysfunction (CAD) plays an important role in all of these transplantations and has a significant influence on patient survival. The pathophysiological reasons for CAD varies greatly in the various organs. Read More

    [Sézary syndrome treated with extracorporeal photopheresis: Report of one case].
    Rev Med Chil 2015 Nov;143(11):1449-58
    Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its stage, patient comorbidities, and treatment availability. Read More

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