312,342 results match your criteria External Pacemakers


Investigations on the prevalence of tortoise picorna-virus in captive tortoises in Germany.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):304-308. Epub 2018 Dec 12.

Objective: Tortoise picornavirus (ToPV) has been speculated to play an important role in the frequently seen disease pattern of juvenile shell softening. This study aimed to determine ToPV prevalence among German tortoise collections.

Material And Methods: A total of 334 animals selected from 27 different collections were included. Read More

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October 2018

Gene expression models based on transcription factor binding events confer insight into functional cis-regulatory variants.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

Motivation: Deciphering the functional roles of cis-regulatory variants is a critical challenge in genome analysis and interpretation. It has been hypothesized that altered transcription factor (TF) binding events are a central mechanism by which cis-regulatory variants impact gene expression levels. However, we lack a computational framework to understand and quantify such mechanistic contributions. Read More

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December 2018

Thyroid Sequelae of Pediatric Cancer Therapy.

Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.

The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More

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December 2018

Decoupling environmental effects and host population dynamics for anthrax, a classic reservoir-driven disease.

PLoS One 2018 12;13(12):e0208621. Epub 2018 Dec 12.

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.

Quantitative models describing environmentally-mediated disease transmission rarely focus on the independent contribution of recruitment and the environment on the force of infection driving outbreaks. In this study we attempt to investigate the interaction between external factors and host's population dynamics in determining the outbreaks of some indirectly transmitted diseases. We first built deterministic and stochastic compartmental models based on anthrax which were parameterized using information from literature and complemented with field observations. Read More

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December 2018

Interacting circadian and homeostatic processes with opportunity cost: A mathematical model of sleep with application to two mammalian species.

PLoS One 2018 12;13(12):e0208043. Epub 2018 Dec 12.

Brigham Young University, Department of Economics, Provo, UT, United States of America.

This paper introduces a new model of sleep for mammals. It extends the classic 'two-process' model of sleep to account for differences in external circumstances. We apply this model to previously-collected data on elephants and sloths, comparing sleep patterns in the wild with sleep patterns in captivity. Read More

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December 2018

A Quartet of Elastic Stable Intramedullary Nails for More Challenging Pediatric Femur Fractures.

J Pediatr Orthop 2019 Jan;39(1):e12-e17

Children's Healthcare of Atlanta.

Introduction: The insertion of 2 elastic stable intramedullary nails (ESINs) is a common treatment for pediatric femur fractures. However, the use of this technique in length-unstable or metadiaphyseal fractures has historically been associated with higher complication rates. To improve stability, the addition of a third ESIN has been assessed biomechanically and clinically, but the addition of a fourth nail has only been evaluated biomechanically. Read More

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January 2019

Persistence on apixaban in atrial fibrillation patients: a retrospective multicentre study.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

MA Provider, Milan, Italy.

Aims: Real-world data on treatment persistence, safety and effectiveness of non-Vitamin K antagonist oral anticoagulants (NOACs) play an important role in the assessment of risks and benefits of these drugs. Our aim was to evaluate persistence on treatment, incidence of major bleeding and incidence of a composite endpoint of major events, including all-cause death, myocardial infarction, stroke and systemic thromboembolism, during treatment with apixaban in a cohort of patients with nonvalvular atrial fibrillation (NVAF).

Methods: In this multicentre retrospective observational study, we retrieved data from medical records of five Italian hospitals on patients with a diagnosis of NVAF who initiated apixaban between 1 January 2014 and 31 March 2016 and had a first subsequent visit at the same hospital. Read More

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December 2018

Two-Team Surgical Approach to Improve Retroperitoneal Nerve Identification in the Treatment of Groin Pain.

Ann Plast Surg 2019 Jan;82(1):82-84

Greater Baltimore Medical Center, Towson, Maryland.

Background: An estimated 700,000 groin hernia repairs are performed in the United States each year. Studies have shown that up to 50% of patients who undergo groin hernia repair are affected by persistent pain beyond the first few days after surgery. At 2 to 5 years after either open or laparoscopic, mesh or without mesh, 10% to 12% of these patients will have persistent and disabling pain. Read More

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January 2019

pH-Responsive Pickering Foams Generated by Surfactant-Free Soft Hydrogel Particles.

Langmuir 2018 Dec 12. Epub 2018 Dec 12.

Pickering foams are foams stabilized by particles and are generally known to have a good stability. A special sub-class of particle stabilized foams is the stimuli-responsive Pickering foams that can be formed or de-constructed by applying an external stimuli or changing the environmental conditions; such intelligent particles could find use in many practical applications. Here, we synthesized the surfactant-free biocompatible poly[2(diethylamino)ethylmethacrylate] (PDEAEMA) hydrogel particles (HGPs) by emulsion polymerization. Read More

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December 2018

Atomically thin NiB monolayer: a robust Dirac material.

Phys Chem Chem Phys 2018 Dec 12. Epub 2018 Dec 12.

Department of Physics and Astronomy, University of Nevada, Las Vegas, Nevada 89154, USA.

Two-dimensional (2D) Dirac materials have attracted extensive research interest due to their high carrier mobility and ballistic charge transport, and they hold great promise for next-generation nanoscale devices. Here, we report a computational discovery of a stable 2D Dirac material, an NiB6 monolayer, which is identified by an extensive structure search, and its dynamic and thermal stabilities are confirmed by phonon and ab initio molecular dynamics (AIMD) simulations. This monolayer structure possesses anisotropic elastic properties with a Young's modulus of 189 N m-1, which is higher than that of phosphorene or silicene. Read More

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December 2018
4.493 Impact Factor

Dynamic split G-quadruplex programmed reversible nanodevice.

Chem Commun (Camb) 2018 Dec 12. Epub 2018 Dec 12.

School of pharmacy, Fujian Medical University, Fuzhou 350004, Fujian Province, China.

We propose a dynamic nanodevice based on a split G-quadruplex (G4). By splitting it apart, we can successfully decouple the G-tetrad formation from external stimuli, greatly expanding the stimulus for G4 based devices. Taking advantage of the rigid force from a DNA duplex, the nanodevice can be switched reversibly through the conformational transformation. Read More

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December 2018

Optimisation of applied loads when using the two-point method for assessing the force-velocity relationship during vertical jumps.

Sports Biomech 2018 Dec 12:1-16. Epub 2018 Dec 12.

c Department of Kinesiology and Applied Physiology & Biomechanics and Movement Science Graduate Program , University of Delaware , Newark , DE , USA.

This study aimed to compare the reliability and validity of the force-velocity (F-V) relationship parameters obtained from two-point methods differing in the distance between experimental points, and to evaluate the acute change in unloaded jump height after a vertical jump testing procedure based on multiple loads. Totally, 18 men randomly performed two sessions of the squat jump (SJ) and two sessions of the countermovement jump (CMJ) exercises against five external loads (17, 30, 45, 60 and 75 kg). The unloaded jump height was evaluated before and after each testing procedure. Read More

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December 2018

A Novel Near-infrared Hyperspectral Absorption/Scattering Imaging Method using Multiple Ground Plates for Evaluating Polymer Composites.

Anal Chem 2018 Dec 12. Epub 2018 Dec 12.

This paper proposes a nondestructive method of evaluating polymer composites using near-infrared (NIR) diffuse reflection spectroscopy with multiple ground plates. Wavelength-dependent absorption and reduced scattering coefficients were acquired to evaluate the chemical structure and the concentration of the substances from absorption and to determine the size and the dispersity of filler in the polymer domain from scattering. NIR spectra of the sample were measured on multiple ground plates, namely, "ground-plate-dependent" diffuse reflection spectra. Read More

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December 2018

Improving Ion Rejection of Conductive Nanofiltration Membrane through Electrically Enhanced Surface Charge Density.

Environ Sci Technol 2018 Dec 12. Epub 2018 Dec 12.

Nanofiltration (NF) is considered a promising candidate for brackish and sea water desalination. NF exhibits high multivalent ion rejection, but the rejection rate for monovalent ions is relatively low. Besides, great challenges remain for conventional NF membranes to achieve high ion rejection without sacrificing water flux. Read More

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December 2018

Nonlinear bending deformation of soft electrets and prospects for engineering flexoelectricity and transverse (d) piezoelectricity.

Soft Matter 2018 Dec 12. Epub 2018 Dec 12.

Department of Mechanical Engineering, University of Houston, Houston, TX 77204, USA. and Department of Physics, University of Houston, Houston, TX 77204, USA.

Soft materials that exhibit electromechanical coupling are an important element in the development of soft robotics, flexible and stretchable electronics, energy harvesters, sensor and actuators. Truly soft natural piezoelectrics essentially do not exist and typical dielectric elastomers, predicated on electrostriction and the Maxwell stress effect, exhibit only a one-way electromechanical coupling. Extensive research however has shown that soft electrets i. Read More

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December 2018

Mapping Caregivers' Health Assets. A self-care project using Salutogenesis and Mindfulness.

Acta Biomed 2018 Dec 7;89(7-S):70-77. Epub 2018 Dec 7.

ADEIT University-Business Foundation, University of Valencia (Spain).

Background: Thousands of caregivers around the world take care of impaired people, with negative repercussions on their physical, psychological, social and economic resources. The need to promote caregivers' wellbeing is internationally recognized, thus reducing health inequalities. Mindfulness is a powerful tool, directly related to the reduction of stress, able to increase skills and attitudes promoting well-being. Read More

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December 2018

Evaluation of the effect of hesperidin on vascular endothelial growth factor gene expression in rat skin animal models following cobalt-60 gamma irradiation.

J Cancer Res Ther 2018 Dec;14(Supplement):S1098-S1104

Department of Radiology and Radiobiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Skin is highly prone to radiation damage. Radiation burn is defined as damage to the skin or other biological tissues induced by radiofrequency or ionizing radiation. Vascular endothelial growth factor (VEGF) is a heparin-binded pro-angiogenic factor. Read More

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December 2018
1 Read

Highly Efficient Fluorescent Organic Light-Emitting Devices Using a Luminescent Radical as the Sensitizer.

J Phys Chem Lett 2018 Dec 12. Epub 2018 Dec 12.

In traditional fluorescent organic light-emitting diodes (OLEDs), the upper limit of internal quantum efficiency (IQE) is only 25% because 75 % triplet excitons created on the fluorescent dyes are non-luminous. Here, luminescent radicals are proposed as the sensitizer. Under ideal conditions, electrons and holes firstly recombine on the sensitizer molecule to create doublet excitons, then through energy transfer to generate singlet excitons on the fluorescent dye, finally via radiative decay to emit light. Read More

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December 2018

Does the recall of caregiver eating messages exacerbate the pathogenic impact of shame on eating and weight-related difficulties?

Eat Weight Disord 2018 Dec 11. Epub 2018 Dec 11.

CINEICC, Center for Research in Neuropsychology and Cognitive Behavioural Intervention, Faculdade de Psicologia e Ciências da Educação, Universidade de Coimbra, Rua do Colégio Novo, Apartado 6153, 3001-802, Coimbra, Portugal.

Purpose: The central role of caregiver eating messages has been recognized on later individual's eating behaviour, body image and weight status. Additionally, shame is a painful emotion also associated with the development and maintenance of body image and eating-related difficulties. The main aim of the present study was to explore the moderator effect of the recall of caregiver eating messages on the associations between external shame, body weight and shape-related concerns, and the adoption of inflexible eating rules. Read More

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December 2018

Autopsy Biobanking: Biospecimen Procurement, Integrity, Storage, and Utilization.

Methods Mol Biol 2019 ;1897:77-87

Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

An autopsy is a specialized surgical procedure consisting of external and internal examination of a deceased individual for the purposes of documenting abnormalities and determining or confirming medical diagnoses that may have contributed to their death. One of the benefits of an autopsy is the opportunity to collect and store biospecimens for the purposes of biobanking. This chapter outlines the procedures necessary to procure, store, and utilize biospecimens obtained during an autopsy. Read More

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January 2019

Mitochondrial health and muscle plasticity after spinal cord injury.

Eur J Appl Physiol 2018 Dec 11. Epub 2018 Dec 11.

James J. Peters VA Medical Center, Bronx, NY, USA.

Mitochondria are responsible for aerobic respiration and large-scale ATP production in almost all cells of the body. Their function is decreased in many neurodegenerative and cardiovascular disease states, in metabolic disorders such as type II diabetes and obesity, and as a normal component of aging. Disuse of skeletal muscle from immobilization or unloading triggers alterations of mitochondrial density and activity. Read More

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December 2018

Inversion of the acetabular labrum causes increased localized contact pressure on the femoral head: a biomechanical study.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan.

Purpose: Although studies suggest that subchondral insufficiency fracture of the femoral head may cause rapidly progressive osteoarthritis of the hip, the mechanism of that relationship remains unclear. Our biomechanical study aimed to provide more data in this area by quantifying pressure distribution on the femoral head for normal and inverted hips and by determining the effects of labral inversion on pressure distribution across the joint, focusing on types of fracture under load.

Methods: We tested mid-sized fourth-generation composite femurs at 15° of adduction, and applied 1 mm/min of axial compressive force to the femoral heads until failure. Read More

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December 2018

Occult injuries of the contralateral sacroiliac joint in operatively treated pelvis fractures: incidence, root cause analysis, and proposal of treatment algorithm.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedics, Denver Health Medical Center, 777 Bannock Street, Denver, CO, 80204, USA.

Purpose: To determine the most common injury patterns, root cause, and the frequency with which unrecognized contralateral posterior ring injury occurs in patients presenting with surgically treated pelvic fractures.

Methods: The medical records of 73 patients presenting to our level I trauma center (52 male and 21 female patients; mean age 41.8 years; range 18-89 years) with surgically treated pelvic ring fractures between January 1, 2016 and January 1, 2018 were reviewed. Read More

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December 2018

The effect of light touch on standing sway when the stability of the external touch reference becomes unreliable.

Exp Brain Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Occupational Therapy, Faculty of Rehabilitation Medicine, University of Alberta, 2-64 Corbett Hall, Edmonton, AB, T6G 2G4, Canada.

Lightly touching a stable reference is associated with sway reduction during standing. Unexpected displacement of the touch reference results in a false-positive balance reaction in some participants, but only with the first such disturbance. This study investigated whether light touch reduces standing sway (1) after the touch reference becomes unreliable, and (2) when participants are aware the touch reference is unreliable. Read More

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December 2018

New therapies for anaplastic thyroid cancer.

Drugs Today (Barc) 2018 Nov;54(11):695-704

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Anaplastic thyroid cancer is a rare but extremely aggressive type of thyroid cancer. Treatment typically consists of surgery, external beam radiotherapy and cytotoxic chemotherapy. However, available literature suggests only modest survival benefit for cytotoxic chemotherapy. Read More

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November 2018

The Movement of f.sp. (Sub-Tropical Race 4) in Susceptible Cultivars of Banana.

Front Plant Sci 2018 27;9:1748. Epub 2018 Nov 27.

School of Agriculture and Food Sciences, The University of Queensland, St Lucia, QLD, Australia.

Fusarium wilt, caused by the fungus f.sp. (), is one of the most important and destructive diseases in banana crops worldwide. Read More

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November 2018

Pathophysiology of Subjective Tinnitus: Triggers and Maintenance.

Front Neurosci 2018 27;12:866. Epub 2018 Nov 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms triggering and maintaining the symptoms, especially for subjective chronic tinnitus. Our objective was to synthesize the published literature in order to provide a comprehensive update on theoretical and experimental advances and to identify further research and clinical directions. Read More

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November 2018

Safety and Efficacy of Low-Dose Single-Agent Capecitabine in Inoperable Gallbladder Cancer with Jaundice Post-Single-System Single-Catheter External Biliary Drainage: a Pilot Study from a Highly Endemic Area.

Indian J Surg Oncol 2018 Dec 31;9(4):530-537. Epub 2018 Jul 31.

1Department of General Surgery, King George's Medical University, Lucknow, UP India.

Gallbladder cancer (CaGB) in the subcontinent belongs to low socioeconomic status, and at the time of diagnosis, a large number is unresectable or inoperable so the palliative treatment remains the only option. In the present study, attempt was made to see the effect and safety profile of single-agent oral capecitabine in inoperable CaGB in presence of low levels of jaundice post-single-catheter transhepatic external biliary drainage. In  = 35 of inoperable jaundiced CaGB, post-biliary drainage capecitabine in low dose was started when their total bilirubin levels fell to 10 mg% or below. Read More

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December 2018

External validation of a bifactor model of oppositional defiant disorder.

Mol Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychology, University of Connecticut, Storrs, CT, USA.

Dimensions of irritability and defiant behavior, though correlated within the structure of ODD, convey separable developmental risks through adolescence and adulthood. Irritability predicts depression and anxiety, whereas defiant behavior is a precursor to antisocial outcomes. Previously we demonstrated that a bifactor model comprising irritability and defiant behavior dimensions, in addition to a general factor, provided the best-fitting structure of ODD symptoms in five large datasets. Read More

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December 2018

Mechanical loading of desmosomes depends on the magnitude and orientation of external stress.

Nat Commun 2018 12 11;9(1):5284. Epub 2018 Dec 11.

Group of Molecular Mechanotransduction, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.

Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells, and are essential for the mechanical integrity of mammalian tissues. Mutations in desmosomal proteins cause severe human pathologies including epithelial blistering and heart muscle dysfunction. However, direct evidence for their load-bearing nature is lacking. Read More

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December 2018

Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Department of Medicine, Division of Cardiology, University of California, Los Angeles, California, USA

Interindividual variation in the composition of the human gut microbiome was examined in relation to demographic and anthropometric traits, and to changes in dietary saturated fat intake and protein source. One hundred nine healthy men and women aged 21 to 65, with BMIs of 18 to 36, were randomized, after a two-week baseline diet, to high (15% total energy [E])- or low (7%E)-saturated-fat groups and randomly received three diets (four weeks each) in which the protein source (25%E) was mainly red meat (beef, pork) (12%E), white meat (chicken, turkey) (12%E), and nonmeat sources (nuts, beans, soy) (16%E). Taxonomic characterization using 16S ribosomal DNA was performed on fecal samples collected at each diet completion. Read More

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December 2018

Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) trimer evades antibody recognition by adopting a closed prefusion conformation. Here, we show that two conserved tyrosines (Y173, Y177) within the second variable (V2) loop of the gp120 Env glycoprotein are key regulators of the closed, antibody-protected state of the trimer by establishing intramolecular interaction with the base of the third variable (V3) loop. Mutation of Y177 and/or Y173 to phenylalanine or alanine dramatically altered the susceptibility of diverse HIV-1 strains to neutralization, increasing sensitivity to weakly and nonneutralizing antibodies directed against diverse Env regions, consistent with the adoption of an open trimer configuration. Read More

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December 2018

Variation in the Use of Boost Irradiation in Breast-Conserving Therapy in the Netherlands: The Effect of a National Guideline and Cofounding Factors.

Clin Oncol (R Coll Radiol) 2018 Dec 8. Epub 2018 Dec 8.

Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands; Department of Health Technology and Services Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands; Scientific Committee NABON Breast Cancer Audit (NBCA), the Netherlands.

Aims: To determine the variation in radiation therapy boost use in a nationwide study following adjustment of a national guideline in 2011, as well as to address the relationship to patient, tumour and radiation therapy institutional factors.

Materials And Methods: All invasive breast cancers and non-invasive breast cancers (ductal carcinoma in situ; DCIS) that received external whole-breast radiation between 2011 and 2016 were selected from the Netherlands Cancer Registry. Box plots were used to evaluate variation over time and logistic regression was carried out to address other factors influencing the variation. Read More

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December 2018

Physical and physiological demands and hormonal responses in basketball small-sided games with different tactical tasks and training regimes.

J Sci Med Sport 2018 Nov 23. Epub 2018 Nov 23.

Lithuanian Sports University, Institute of Sport Science and Innovations, Lithuania.

Objectives: To evaluate external and internal training load (TL) and hormonal responses in basketball 3-versus-3 small-sided games (SSGs).

Design: Randomized repeated-measures study.

Methods: Twelve male basketball players participated to four 3-versus-3 SSGs characterized by different tactical tasks (offensive; defensive) and training regimes (long-intermittent: three 4-min bouts with 2' rest in between; short-intermittent: six 2-min bouts with 1' rest in between). Read More

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November 2018

Application of atomic force microscopy in cancer research.

J Nanobiotechnology 2018 Dec 11;16(1):102. Epub 2018 Dec 11.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and molecules. Recent advances have enabled its application in cancer research and diagnosis. The physicochemical properties of live cells undergo changes when their physiological conditions are altered. Read More

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December 2018

Distribution- and anchor-based methods to determine the minimally important difference on patient-reported outcome questionnaires in oncology: a structured review.

Health Qual Life Outcomes 2018 Dec 11;16(1):228. Epub 2018 Dec 11.

Methodology and Quality of Life in Oncology Unit (INSERM UMR 1098), University Hospital of Besançon, Besançon, France.

Background: Interpretation of differences or changes in patient-reported outcome scores should not only consider statistical significance, but also clinical relevance. Accordingly, accurate determination of the minimally important difference (MID) is crucial to assess the effectiveness of health care interventions, as well as for sample size calculation. Several methods have been proposed to determine the MID. Read More

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December 2018

Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling.

BMC Genomics 2018 Dec 11;19(Suppl 8):857. Epub 2018 Dec 11.

Bioinformatics and Functional Genomics Group, Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Cientificas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.

Background: Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors. In this work, we identified a new set of gene markers for CRC associated to prognosis and risk using a large unified cohort of patients with transcriptomic profiles and survival information. Read More

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December 2018

External bleeding versus dermal pocketing for distal digital replantation without venous anastomosis.

J Hand Surg Eur Vol 2018 Dec 11:1753193418817979. Epub 2018 Dec 11.

National University Hospital, NUHS Tower Block National University Hospital Singapore, Singapore.

Venous congestion in distal digital replantations is a common problem as suitable veins are not always available. We compared two methods of venous decongestion, external bleeding ( n = 15) and dermal pocketing ( n = 28) carried out when venous anastomosis was not possible. The findings of this small study suggest that neither method of venous decongestion is clearly better than the other. Read More

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December 2018

Iliac artery fibromuscular dysplasia successfully treated by balloon angioplasty guided by intravascular ultrasound and pressure wire measurements: A case report.

J Cardiol Cases 2014 May 28;9(5):203-207. Epub 2014 Feb 28.

Department of Cardiology, Kishiwada Tokushukai Hospital, Osaka, Japan.

A 71-year-old woman was admitted with a 6-month history of lower limb intermittent claudication. She had well-controlled hypertension and no other risk factor of atherosclerosis. Angiographic findings revealed the "string of beads" pattern in bilateral renal arteries and external iliac arteries. Read More

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A case of primary aldosteronism who experienced cardiopulmonary arrest, was resuscitated and cured.

J Cardiol Cases 2014 Feb 16;9(2):63-66. Epub 2013 Dec 16.

Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

A 45-year-old female went into cardiopulmonary arrest. She was in ventricular fibrillation (VF) and was defibrillated using an automated external defibrillator. After arrival at our hospital, electrocardiography monitoring showed QT prolongation. Read More

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February 2014

Successful coronary intervention for spontaneous coronary dissection in a patient with fibromuscular dysplasia.

J Cardiol Cases 2013 Nov 2;8(5):158-160. Epub 2013 Oct 2.

Department of Cardiology and Renal Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8556, Japan.

Spontaneous coronary artery dissection (SCAD) is a reported rare cause of acute coronary syndrome (ACS) and sudden death among middle-aged women. Some institutes have recently reported fibromuscular dysplasia (FMD) concomitant with SCAD. Therefore, a survey of the presence of comorbid FMD in SCAD patients is important to obtain a definitive diagnosis and for the prediction of possible SCAD recurrence. Read More

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November 2013

Case of Takotsubo cardiomyopathy after tooth extraction - Unusual trigger of a rare syndrome.

J Cardiol Cases 2014 Oct 17;10(4):129-131. Epub 2014 Jul 17.

Division of Cardiology, Schuechtermann Clinic, Bad Rothenfelde, Germany.

We describe a case of Takotsubo cardiomyopathy in a 75-year-old woman after an elective extraction of 10 teeth of the lower jaw using bilateral mandibular anesthesia. The patient complained of shortness of breath and chest pain after 24 h. Coronary angiography showed smooth normal coronary arteries with thrombolysis in myocardial infarction III flow. Read More

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October 2014

Zilver stent implantation through 4.5 French guiding sheath in iliac vein compression syndrome complicated with acute deep vein thrombosis.

J Cardiol Cases 2013 Feb 6;7(2):e53-e56. Epub 2012 Dec 6.

Departments of Cardiology, Kyoto First Red Cross Hospital, Honmachi, Higashiyama-ku, Kyoto 605-0981, Japan.

Background: Downsized devices for less invasive endovascular treatment are gaining more attention.

Case Report: An 82-year-old woman was admitted to our hospital with pain and swelling in left lower extremity. Ultrasonography showed much thrombus at the left common femoral, superficial femoral, and popliteal veins, confirming a diagnosis of acute deep vein thrombosis (DVT). Read More

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February 2013

A case of idiopathic ventricular fibrillation in which implanted loop recorder was useful in application decision for implantation of implantable cardioverter-defibrillator.

J Cardiol Cases 2012 Aug 20;6(2):e59-e63. Epub 2012 Jun 20.

Division of Cardiology, Department of Internal Medicine, Uwajima City Hospital, Goten-machi 1-1, Uwajima, Ehime 798-8510, Japan.

Establishing a symptom-rhythm correlation in patients with unexplained syncope is complicated because of its sporadic, infrequent, and unpredictable nature. Recently, an implantable loop recorder (ILR) has become available to evaluate undiagnosed recurrent arrhythmic episodes particularly in unexplained syncopes, and its usefulness has been reported in patients with recurrent syncopes that remain unexplained after conventional work-up. A 65-year-old man was referred to our hospital for loss of consciousness with nocturnal paroxysmal seizures. Read More

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Subclavicular screwed wire transient pacing to increase safety of transcatheter aortic valve implantation with the CoreValve system.

J Cardiol Cases 2011 Jun 6;3(3):e167-e169. Epub 2011 Apr 6.

Department of Cardiology, CHU Timone, Rue St Pierre, Marseille 13005, France.

Regarding the risk of atrioventricular block during the first days following transcatheter aortic valve implantation (TAVI), temporary pacing is required. Conventional transfemoral temporary pacing catheters have several drawbacks including the risk of cardiac perforation, infection, and the absence of any fixation mechanism. We describe a case of TAVI procedure with safer temporary pacing, using subclavicular active-fixation pacemaker electrode and external generator. Read More

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Successful stenting to superior mesenteric artery (SMA) after endovascular aneurysm repair (EVAR) of abdominal aorta.

J Cardiol Cases 2010 Oct 6;2(2):e78-e82. Epub 2010 May 6.

Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center 5-3-1 Chikami, Kumamoto-city, 861-4193, Japan.

A 70-year-old man complained of abdominal angina after endovascular aneurysm repair (EVAR). He had a history of successful treatment of abdominal aortic aneurysm with Zenith endovascular graft 12 months prior to the index abdominal symptoms. The endovascular graft had been placed with special attention for keeping blood flow of major abdominal branches to the intestine. Read More

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October 2010

Metabolite changes in blood predict the onset of tuberculosis.

Nat Commun 2018 12 6;9(1):5208. Epub 2018 Dec 6.

Max Planck Institute for Infection Biology, 10117, Berlin, Germany.

New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3-24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. Read More

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December 2018

Manipulating and monitoring nanoparticles in micellar thin film superstructures.

Nat Commun 2018 12 6;9(1):5207. Epub 2018 Dec 6.

Laboratory of BioNanoTechnology, Wageningen University & Research, Axis, Bornse Weilanden 9, 6708 WG, Wageningen, The Netherlands.

Understanding the dynamics of discrete self-assembled structures under influence of external triggers is of interest to harvest the potential of nano- and mesoscale materials. In particular, controlling the hierarchical organization of (macro)molecular and nanoparticle building blocks in monolayer superstructures is of paramount importance for tuning properties and characteristics. Here we show how the electron beam in cryo-transmission electron microscopy can be exploited to induce and follow local migration of building blocks and global migration of micellar aggregates inside micrometer-sized superstructures. Read More

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December 2018

Nomogram Model to Predict Cardiorenal Syndrome Type 1 in Patients with Acute Heart Failure.

Kidney Blood Press Res 2018 Dec 7;43(6):1832-1841. Epub 2018 Dec 7.

Background/aims: Cardiorenal syndrome type 1(CRS1) is a serious clinical condition in patients with acute heart failure (AHF) associated with adverse clinical outcomes. Although several biomarkers for identifying CRS1 have been reported, early and accurate predicting CRS1 still remains a challenge. This study was aimed to develop and validate an individualized predictive nomogram for the risk of CRS1 in patients with AHF. Read More

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December 2018

Comparing two high correlation models to test the mechanical stability of Americium-II.

J Phys Condens Matter 2018 Dec 11. Epub 2018 Dec 11.

Instituto de Fisica, Benemerita Universidad Autonoma de Puebla, 18 sur y av. San Claudio, CU, San Manuel, Puebla, Puebla, 72570, MEXICO.

In this work two high DFT correlation methodologies, the so called DFT+U (or GGA+U) implementation and the eece hybrid DFT functional (or one case of HYB-DFT), are tested to determine the mechanical properties of Americium-II. For each case, the numeric value of their principal parameter is chosen (U for the first case and α for the second one) once the crystalline structure meets all the mechanical stability conditions. The results show that there is a range of values of U and α in which both methodologies generate a stable (experimentally correct) non-magnetic ground state, reaching approximately the same numeric value of the set of elastic constants of the cubic structure. Read More

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December 2018
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