335 results match your criteria External Pacemakers

A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy.

Science 2022 05 26;376(6596):1006-1012. Epub 2022 May 26.

Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. Read More

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Multiscale Time-resolved Analysis Reveals Remaining Behavioral Rhythms in Mice Without Canonical Circadian Clocks.

J Biol Rhythms 2022 Jun 16;37(3):310-328. Epub 2022 May 16.

Department of Physics, Lancaster University, Lancaster, UK.

Circadian rhythms are internal processes repeating approximately every 24 hours in living organisms. The dominant circadian pacemaker is synchronized to the environmental light-dark cycle. Other circadian pacemakers, which can have noncanonical circadian mechanisms, are revealed by arousing stimuli, such as scheduled feeding, palatable meals and running wheel access, or methamphetamine administration. Read More

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Prevalence of Titanium Hypersensitivity in Patients with Titanium Implants: A Systematic Review and Meta-analysis.

J Pharm Bioallied Sci 2021 Nov 10;13(Suppl 2):S1345-S1349. Epub 2021 Nov 10.

Department of OMFS, Narsinbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.

Background: With increase in exposure to titanium in daily life and its use in medical procedures, there is a greater chance for developing titanium hypersensitivity. Our aim and objective is to examine whether patient patients with titanium implants had a greater incidence of titanium hypersensitivity or not. Titanium is widely considered to have good biocompatibility. Read More

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November 2021

Hubs, diversity, and synchronization in FitzHugh-Nagumo oscillator networks: Resonance effects and biophysical implications.

Phys Rev E 2021 May;103(5-1):052211

National Institute of Chemical Physics and Biophysics, Rävala 10, Tallinn 15042, Estonia.

Using the FitzHugh-Nagumo equations to represent the oscillatory electrical behavior of β-cells, we develop a coupled oscillator network model with cubic lattice topology, showing that the emergence of pacemakers or hubs in the system can be viewed as a natural consequence of oscillator population diversity. The optimal hub to nonhub ratio is determined by the position of the diversity-induced resonance maximum for a given set of FitzHugh-Nagumo equation parameters and is predicted by the model to be in a range that is fully consistent with experimental observations. The model also suggests that hubs in a β-cell network should have the ability to "switch on" and "off" their pacemaker function. Read More

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Innovation in Permanent Pacemaker's Implantation Technique: Trans-Axillary Approach.

Cureus 2021 Apr 12;13(4):e14436. Epub 2021 Apr 12.

Vascular Surgery, Kahutta Research Laboratory (KRL) Hospital, Islamabad, PAK.

Introduction: Permanent pacemakers' (PPM) implantation is an integral part of electrophysiology and general cardiology. The implantation technique has evolved a lot since the first implantation. Several innovations have been undertaken to improve the effectiveness, life of the transplant, and patient outcomes. Read More

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Shining light on cardiac electrophysiology: From detection to intervention, from basic research to translational applications.

Life Sci 2021 Jun 15;274:119357. Epub 2021 Mar 15.

Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China. Electronic address:

Cardiac arrhythmias are an important group of cardiovascular diseases, which can occur alone or in association with other cardiovascular diseases. The development of cardiac arrhythmias cannot be separated from changes in cardiac electrophysiology, and the investigation and clarification of cardiac electrophysiological changes are beneficial for the treatment of cardiac arrhythmias. However, electrical energy-based pacemakers and defibrillators, which are widely used to treat arrhythmias, still have certain disadvantages. Read More

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Periodic unitary synaptic currents in the mouse globus pallidus during spontaneous firing in slices.

J Neurophysiol 2021 04 17;125(4):1482-1500. Epub 2021 Mar 17.

Department of Biology, The University of Texas at San Antonio, San Antonio, Texas.

Neurons in the external globus pallidus (GPe) are autonomous pacemakers, but their spontaneous firing is continually perturbed by synaptic input. Because GPe neurons fire rhythmically in slices, spontaneous inhibitory synaptic currents (IPSCs) should be evident there. We identified periodic series of IPSCs in slices, each corresponding to unitary synaptic currents from one presynaptic cell. Read More

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Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior.

Front Cell Neurosci 2021 2;15:635837. Epub 2021 Feb 2.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.

Sensory perception underlies how we internalize and interact with the external world. In order to adapt to changing circumstances and interpret signals in a variety of contexts, sensation needs to be reliable, but perception of sensory input needs to be flexible. An important mediator of this flexibility is top-down regulation from the cholinergic basal forebrain. Read More

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February 2021

Measurement of T1 Mapping in Patients With Cardiac Devices: Off-Resonance Error Extends Beyond Visual Artifact but Can Be Quantified and Corrected.

Front Cardiovasc Med 2021 29;8:631366. Epub 2021 Jan 29.

Institute for Cardiovascular Science, University College London, London, United Kingdom.

Measurement of myocardial T1 is increasingly incorporated into standard cardiovascular magnetic resonance (CMR) protocols, however accuracy may be reduced in patients with metallic cardiovascular implants. Measurement is feasible in segments free from visual artifact, but there may still be off-resonance induced error. To quantify off-resonance induced T1 error in patients with metallic cardiovascular implants, and validate a method for error correction for a conventional MOLLI pulse sequence. Read More

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January 2021

Relation of Antecedent Symptoms to the Likelihood of Detecting Subclinical Atrial Fibrillation With Inserted Cardiac Monitors.

Am J Cardiol 2021 04 23;145:64-68. Epub 2021 Jan 23.

Medtronic, Minneapolis, Minnesota.

Atrial fibrillation (AF) comes to attention clinically during an evaluation of symptoms, an evaluation of its adverse outcomes, or because of incidental detection during a routine examination or electrocardiogram. However, a notable number of additional individuals have AF that has not yet been clinically apparent or suspect-subclinical AF (SCAF). SCAF has been recognized during interrogation of pacemakers and defibrillators. Read More

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Updated Approaches to Cardiac Electrical Stimulation and Pacing in Pediatrics.

Pediatr Emerg Care 2020 Sep;36(9):430-439

From the Assistant Professors and Professor, Section of Emergency Medicine, Department of Pediatrics (Neubrand, Topoz and Mistry), University of Colorado/Children's Hospital Colorado, Aurora, CO.

Cardiac electrical stimulation is a rarely used but required skill for pediatric emergency physicians. Children who are in cardiac arrest or who demonstrate evidence of hypoperfusion because of cardiac reasons require rapid diagnosis and intervention to minimize patient morbidity and mortality. Both hospital- and community-based personnel must have sufficient access to, and knowledge of, appropriate equipment to provide potentially lifesaving defibrillation, cardioversion, or cardiac pacing. Read More

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September 2020

Gender-Based Differences in the Relationships Among Social Support, Positive Psychological Capital, and Sleep Quality in Patients Implanted With Pacemakers: A Moderated Mediation Model.

J Cardiovasc Nurs 2022 Jan-Feb 01;37(1):79-85

Background: Sleep disorders are common and seriously affect the prognosis of patients implanted with pacemakers.

Aims: In this study, it was investigated whether social support directly impacts sleep quality and whether positive psychological capital mediates and gender moderates the relationship between social support and sleep quality among this group.

Methods: A total of 178 patients implanted with pacemakers were recruited to participate in the study from 2 tertiary hospitals in Shandong, China. Read More

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A Review of Temporary Permanent Pacemakers and a Comparison with Conventional Temporary Pacemakers.

J Innov Card Rhythm Manag 2019 May 15;10(5):3652-3661. Epub 2019 May 15.

Section of Electrophysiology & Pacing, Division of Cardiology, Department of Medicine, Baylor Scott & White Temple Memorial Hospital, Baylor Scott & White Health, Dallas, TX, USA.

Temporary cardiac pacing is commonly used in patients with life-threatening bradycardia and serves as a bridge to implantation of a permanent pacemaker (PPM). For years, passive fixation leads have been used for this purpose, offering the advantage of that they can be placed at bedside. The downside, however, is that patients must remain on telemetry and bed rest until lead removal due to the risk of displacement and failure to capture. Read More

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Causes of Failure to Capture in Pacemakers and Implantable Cardioverter-defibrillators.

J Innov Card Rhythm Manag 2020 Feb 15;11(2):4013-4017. Epub 2020 Feb 15.

Division of Electrophysiology, Department of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, OH, USA.

The number of patients with implantable electronic cardiac devices is continuously increasing. As more pacemakers and implantable cardioverter-defibrillators (ICDs) are being placed, a basic understanding of some troubleshooting for devices is becoming essential. Loss of capture can be an emergent presentation for an unstable patient and can be encountered intermittently in hospitalized patients. Read More

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February 2020


Harefuah 2020 Mar;159(3):195-200

Cardiology Department, HaEmek Medical Center, Afula.

Introduction: Remote monitoring (RM) of patients with cardiovascular implantable electronic devices (CIED) offers clinical benefits by providing early alert for system failure and actionable changes in patient health. Professional societies recommend utilization of RM for CIED patients (Level of recommendation I Level of evidence A). It must be emphasized that RM technology does not provide continuous monitoring but rather "remote snapshot clinics". Read More

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Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers.

Sci Rep 2020 02 7;10(1):2067. Epub 2020 Feb 7.

Texas Heart Institute, 6770 Bertner Avenue, Houston, TX, 77030, USA.

About 30% of patients with impaired cardiac function have ventricular dyssynchrony and seek cardiac resynchronization therapy (CRT). In this study, we demonstrate synchronized biventricular (BiV) pacing in a leadless fashion by implementing miniaturized and wirelessly powered pacemakers. With their flexible form factors, two pacemakers were implanted epicardially on the right and left ventricles of a porcine model and were inductively powered at 13. Read More

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February 2020

Phantom Model Testing of Active Implantable Cardiac Devices at 50/60 Hz Electric Field.

Bioelectromagnetics 2020 Feb 5;41(2):136-147. Epub 2020 Jan 5.

EDF SEM, Levallois-Perret, France.

Exposure to external extremely low-frequency (ELF) electric and magnetic fields induces the development of electric fields inside the human body, with their nature depending on multiple factors including the human body characteristics and frequency, amplitude, and wave shape of the field. The objective of this study was to determine whether active implanted cardiac devices may be perturbed by a 50 or 60 Hz electric field and at which level. A numerical method was used to design the experimental setup. Read More

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February 2020

Photoelectric Cardiac Pacing by Flexible and Degradable Amorphous Si Radial Junction Stimulators.

Adv Healthc Mater 2020 01 3;9(1):e1901342. Epub 2019 Dec 3.

National Laboratory of Solid State Microstructures, School of Electronics Science and Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, P. R. China.

Implanted pacemakers are usually bulky and rigid electronics that are constraint by limited battery lifetimes, and need to be installed and repaired via surgeries that risk secondary infection and injury. In this work, a flexible self-powered photoelectric cardiac stimulator is demonstrated based on hydrogenated amorphous Si (a-Si:H) radial p-i-n junctions (RJs), constructed upon standing Si nanowires grown directly on aluminum thin foils. The flexible RJ stimulators, with an open-circuit voltage of 0. Read More

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January 2020

Investigation into the effect of transcranial direct current stimulation on cardiac pacemakers.

Brain Stimul 2020 Jan - Feb;13(1):89-95. Epub 2019 Aug 17.

Rotman Research Institute, Baycrest Health Science, Toronto, Canada; Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Chemin de la cote Sainte-Catherine, H3T 1E2, Montreal, Quebec, Canada. Electronic address:

Background: Studies investigating the therapeutic applications of transcranial direct current stimulation (tDCS) in the treatment of age-related neurodegenerative disease have been promising. However, exclusion criteria for these studies invariably disqualify patients implanted with internal cardiac pacemakers, citing safety concerns. Because the majority of cardiac pacemaker implantees are over 65, this criterion may limit candidacy for tDCS based research and/or treatment of age-related neurodegenerative disease. Read More

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Update in Cardiac Pacing.

Arrhythm Electrophysiol Rev 2019 Jul;8(3):228-233

Division of Cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine Chicago, IL, US.

Initial efforts to artificially stimulate the heart were borne out of a necessity to prevent catastrophic bradycardic events. The initial pacemaker systems were large, bulky external devices. However, advancements in technology allowed for the development of internally powered, fully implantable devices. Read More

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Stress echocardiography. Part I: Stress echocardiography in coronary heart disease.

J Ultrason 2019 ;19(76):45-48

Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, School of Medicine in Katowice , Poland ; Cardiac Rehabilitation Department Treatment and Rehabilitation Center, Long-Term Care Hospital , Jaworze , Poland.

Stress echocardiography (stress echo) is a method in which various stimuli are used to elicit myocardial contractility or provoke cardiac ischemia with simultaneous echocardiographic image acquisition of left ventricular function and valvular flow, if needed. The technique is a well-recognized, safe and widely available stress test used for the diagnosis and assessment of prognosis in coronary heart disease, but may also prove valuable in valvular heart disease. The stressors used include physical exercise, pharmacological agents (dobutamine, vasodilators) and pacing stress, most often with the use of a permanent pacemaker. Read More

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January 2019

Epicardial pacemaker as a bridge for pacemaker-dependent patients undergoing explantation of infected cardiac implantable electronic devices.

J Card Surg 2019 Jun 24;34(6):424-427. Epub 2019 Apr 24.

Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Background And Aim Of The Study: Cardiac implantable electronic device (CIED) implantation is associated with an increase in CIED infection. For pacemaker-dependent patients, temporary pacemaker leads are implanted until infection remission, which allows new CIED implantation. We compared the outcome of pacemaker-dependent patients with infected CIED based on whether a combined single procedure of epicardial pacemaker implantation with system extraction or a temporary transjugular pacemaker implantation with interval system implantation was performed. Read More

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Direct Powering a Real Cardiac Pacemaker by Natural Energy of a Heartbeat.

ACS Nano 2019 03 20;13(3):2822-2830. Epub 2019 Feb 20.

Institute of Cardiothoracic Surgery at Changhai Hospital , Second Military Medical University , Shanghai 200433 , China.

Implantable medical devices are widely used for monitoring and treatment of severe diseases. In particular, an implantable cardiac pacemaker is the most effective therapeutic device for treating bradyrhythmia, however its surgical replacement is inevitable every 5-12 years due to the limited life of the built-in battery. Although several approaches of energy harvesting have been explored in this decade for powering cardiac pacemakers, the modern, commercial, and full-function pacemaker has never been powered effectively yet. Read More

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MRI for patients with cardiac implantable electronic devices: simplifying complexity with a 'one-stop' service model.

BMJ Qual Saf 2019 10 13;28(10):853-858. Epub 2019 Feb 13.

Department of Cardiac Imaging, Barts Heart Centre, Barts Health NHS Trust, London, UK.

Background: Patients with cardiac pacemakers and defibrillators are disadvantaged because of poor access to MRI scans, leading to late and misdiagnosis particularly for cancer and neurological disease. New technology allied to tested protocols now allows safe MRI scanning of such patients; however, logistical barriers persist.

Aim: To deliver a streamlined sustainable service that provides timely MRI scans to patients with cardiac implantable electronic devices (CIEDs). Read More

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October 2019

A randomized trial evaluating the accuracy of AF detection by four external ambulatory ECG monitors compared to permanent pacemaker AF detection.

J Interv Card Electrophysiol 2020 Apr 11;57(3):361-369. Epub 2019 Feb 11.

Eastbourne General Hospital, East Sussex Healthcare NHS Trust, East Sussex, UK.

Purpose: Several external cardiac monitors (ECMs) have recently been developed. These have never been compared to 'gold standard' monitoring with concurrently implanted DDDRP pacemakers. The accuracy of AF detection of Zio XT Monitor (ZM), NUUBO Vest (NV) and Carnation Ambulatory Monitor (CAM) compared with Novacor 'R' Test 4 (RT) in patients (pts) with DDDRP PPM advanced Holters as the comparator, was evaluated. Read More

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Mechanisms of Communication in the Mammalian Circadian Timing System.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Institute of Neurobiology, Center of Brain, Behavior and Metabolism, University of Lübeck, Marie-Curie-Straße, 23562 Lübeck, Germany.

24-hour rhythms in physiology and behaviour are organized by a body-wide network of endogenous circadian clocks. In mammals, a central pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) integrates external light information to adapt cellular clocks in all tissues and organs to the external light-dark cycle. Together, central and peripheral clocks co-regulate physiological rhythms and functions. Read More

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January 2019

Experimental Phantom-Based Security Analysis for Next-Generation Leadless Cardiac Pacemakers.

Sensors (Basel) 2018 Dec 7;18(12). Epub 2018 Dec 7.

iTEAM, Universitat Politècnica de València, 46022 Valencia, Spain.

With technological advancement, implanted medical devices can treat a wide range of chronic diseases such as cardiac arrhythmia, deafness, diabetes, etc. Cardiac pacemakers are used to maintain normal heart rhythms. The next generation of these pacemakers is expected to be completely wireless, providing new security threats. Read More

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December 2018