312,574 results match your criteria External Ear Infections


Developmental mutant mouse models for external genitalia formation.

Congenit Anom (Kyoto) 2018 Nov 22. Epub 2018 Nov 22.

Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Wakayama, Japan.

Development of external genitalia and perineum is the subject of developmental biology as well as toxicology and teratology researches. Cloaca forms in the lower (caudal) end of endoderm. Such endodermal epithelia and surrounding mesenchyme interact with various signals to form the external genitalia. Read More

View Article
November 2018

A new approach of assessing patient safety aspects in routine practice using the example of "doctors handwritten prescriptions".

J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.

Research Unit for Safety in Health, c/o Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Austria.

Aims And Objectives: The aim of this study was to test the method of self- and external assessment as a feedback system to decrease illegibility and incorrectness of handwritten prescriptions and to reduce additional workload for nursing staff.

Background: Illegibility and incorrectness of handwritten prescriptions occur very often and are the most crucial factors affecting patient safety.

Design: Self- versus external assessment using a 15 items checklist. Read More

View Article
December 2018

Radiotherapy for oligometastatic cancer: a survey among radiation oncologists of Lombardy (AIRO-Lombardy), Italy.

Radiol Med 2018 Dec 15. Epub 2018 Dec 15.

S. C. Radioterapia, ASST dei Sette Laghi-Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Aims: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy.

Methods And Study Design: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. Read More

View Article
December 2018

Unhealthy lifestyle and oxidative damage in childhood obesity.

Eat Weight Disord 2018 Dec 15. Epub 2018 Dec 15.

Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Purpose: Oxidized LDL cholesterol (oxLDL) has been considered as a sensor of oxidative stress (OS) in childhood obesity. We integrated and related our oxLDL existing results previously assessed in overweight/obese children to lifestyle variables to investigate OS-related lifestyle variables.

Methods: 178 Caucasian children/adolescents have been evaluated and according to BMI percentiles have been classified as normal weight (BMI < 75th); overweight (BMI 75-97th) and obese (BMI > 97th). Read More

View Article
December 2018

Endodontic sealers based on calcium silicates: a systematic review.

Odontology 2018 Dec 15. Epub 2018 Dec 15.

Central Interdisciplinary Ambulance in the School of Dentistry, Albert-Schweitzer-Campus 1, Building W 30, 48149, Münster, Germany.

Recently, sealers based on calcium silicates were developed as a new class of endodontic sealers. Inspired by the excellent sealing ability and biocompatibility of calcium silicate-based cements, these sealers establish a biological point of view on the obturation of root canals. No longer, the bacteria-tight seal against reinfection of the root canal is the only goal of root canal obturation. Read More

View Article
December 2018

Consensus Statement of the Italian Society of Colorectal Surgery (SICCR): management and treatment of complete rectal prolapse.

Tech Coloproctol 2018 Dec 15. Epub 2018 Dec 15.

Department of Colorectal Surgery, Santa Rita Clinic, Vercelli, Italy.

Rectal prolapse, rectal procidentia, "complete" prolapse or "third-degree" prolapse is the full-thickness prolapse of the rectal wall through the anal canal and has a significant impact on quality of life. The incidence of rectal prolapse has been estimated to be approximately 2.5 per 100,000 inhabitants with a clear predominance among elderly women. Read More

View Article
December 2018
1 Read

Prognostic models for predicting overall survival in metastatic castration-resistant prostate cancer: a systematic review.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

UroEvidence@Deutsche Gesellschaft für Urologie, Berlin, Germany.

Purpose: Prognostic models are developed to estimate the probability of the occurrence of future outcomes incorporating multiple variables. We aimed to identify and summarize existing multivariable prognostic models developed for predicting overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC).

Methods: The protocol was prospectively registered (CRD42017064448). Read More

View Article
December 2018

Exchanges of nitrogen and phosphorus across the sediment-water interface influenced by the external suspended particulate matter and the residual matter after dredging.

Environ Pollut 2018 Dec 5;246:207-216. Epub 2018 Dec 5.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, PR China; Jiangsu Provincial Key Laboratory of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, PR China.

Dredging is frequently implemented for the reduction of internal nitrogen (N) and phosphorus (P) loadings and the control of eutrophication. Residuals during dredging activities and external pollution loadings after dredging both commonly contribute to influence the effectiveness of dredging and have been widely discussed. In the current study, the exchanges of N and P across the sediment-water interface (SWI) to these two factors were compared in a six-month field incubation experiment. Read More

View Article
December 2018

Clinical tests to determine femoral version category in people with chronic hip joint pain and asymptomatic controls.

Musculoskelet Sci Pract 2018 Dec 10;39:115-122. Epub 2018 Dec 10.

Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, United States; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States. Electronic address:

Study Design: Controlled laboratory cross-sectional.

Objectives: To investigate the relationship between femoral version (FV), measured by MRI (FVMRI), Craig's test and hip rotation range of motion (ROM). To determine rotation ROM values associated with FVMRI categories: excessive anteversion, normal version and retroversion. Read More

View Article
December 2018

A novel experimental approach for liver analysis in rats exposed to Bisphenol A by means of LC-mass spectrometry and infrared spectroscopy.

J Pharm Biomed Anal 2018 Dec 10;165:207-212. Epub 2018 Dec 10.

Department of Experimental Medicine, University of Campania "L. Vanvitelli", Via S. M. di Costantinopoli, 16, 80138, Naples, Italy.

An innovative complementary approach using a liquid chromatographic-mass spectrometer method and infrared spectroscopy is proposed for measuring internal biological exposure to dangerous chemical contaminants and for monitoring biochemical changes in target organs. The proposed methodologies were validated and applied in the case of rats exposed to low-doses of Bisphenol A (BPA). A liquid chromatographic method coupled to a tandem mass spectrometer was used in order to measure BPA concentration in rat livers. Read More

View Article
December 2018

Is your assay stable? Using process stability and capability to evaluate assay performance.

Clin Chim Acta 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT, United States. Electronic address:

Background: Many laboratories are involved in efforts to increase precision and improve process capability. Metrics to evaluate performance, assess potential for improvement, and prioritize improvement projects would facilitate these efforts. We show how stability analysis can provide metrics to evaluate assay performance and indicate potential for improvement. Read More

View Article
December 2018

Determining the target of membrane sterols on voltage-gated potassium channels.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 13. Epub 2018 Dec 13.

Division of Biophysics, Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Egyetem ter 1., H-4032, Hungary; MTA-DE-NAP B Ion Channel Structure-Function Research Group, RCMM, University of Debrecen, Debrecen, Egyetem ter 1., H-4032, Hungary. Electronic address:

Cholesterol, an essential lipid component of cellular plasma membranes, regulates fluidity, mechanical integrity, raft structure and may specifically interact with membrane proteins. Numerous effects on ion channels by cholesterol, including changes in current amplitude, voltage dependence and gating kinetics, have been reported. We have previously described such changes in the voltage-gated potassium channel K1. Read More

View Article
December 2018
1 Read

Impact of degree of stenosis in May-Thurner syndrome on iliac vein stenting.

J Vasc Surg Venous Lymphat Disord 2018 Dec 12. Epub 2018 Dec 12.

The RANE Center for Venous and Lymphatic Diseases, St. Dominic Hospital, Jackson, Miss.

Objective: May-Thurner syndrome (MTS) patients with lifestyle-limiting symptoms undergo stenting of the iliac vein for relief of compressive disease. The impact of degree of stenosis on clinical symptoms and outcomes after stenting is unknown and examined in our study.

Methods: Retrospective review of contemporaneously entered data of 202 patients who underwent stenting for MTS between 2005 and 2011 was performed. Read More

View Article
December 2018

Different patterns of white matter changes after successful surgery of mesial temporal lobe epilepsy.

Neuroimage Clin 2018 Dec 8:101631. Epub 2018 Dec 8.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objectives: To explore the dynamic changes of white matters following anterior temporal lobectomy (ATL) in mesial temporal lobe epilepsy (MTLE) patients who achieved seizure-free at two-year follow-up.

Methods: Diffusion tensor imaging (DTI) was obtained in ten MTLE patients at five serial time points: before surgery, three months, six months, 12 months and 24 months after surgery, as well as in 11 age- and sex-matched healthy controls at one time point. Regions with significant postoperative fractional anisotropy (FA) changes and their dynamic changes were confirmed by comparing all preoperative and postoperative data using Tract-Based Spatial Statistics (TBSS). Read More

View Article
December 2018

Using bifurcated endoprosthesis after iliac artery recanalization for concomitant abdominal aortic aneurysm and chronic total occlusions of access routes.

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Vascular Surgery, Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.

Objective: Concurrent abdominal aortic aneurysm (AAA) and unilateral iliac occlusion is a challenge in the implantation of bifurcated stent grafts (BFGs). The endovascular approach is less invasive than open surgery; the aortouni-iliac (AUI) graft with crossover femorofemoral bypass (CFFB) has many problems associated with extra-anatomic reconstruction. We attempted endovascular aneurysm repair (EVAR) using BFGs in such cases and evaluated the outcomes. Read More

View Article
December 2018

Extended state observer based output control for spacecraft rendezvous and docking with actuator saturation.

ISA Trans 2018 Dec 6. Epub 2018 Dec 6.

National Key Laboratory of Aerospace Flight Dynamics, Xi'an, Shaanxi 710072, China; College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China. Electronic address:

This paper investigates the relative position tracking and attitude synchronization problem of a chaser spacecraft rendezvous and docking with an uncontrolled tumbling target in the presence of external disturbances and actuator saturation. By combining the extended state observer technique with backstepping control methodology, a robust output-feedback control strategy with no precise motion information of the tumbling target is proposed. Moreover, a particular Nussbaum-type function is introduced to compensate for the nonlinear terms arising for actuator saturation. Read More

View Article
December 2018

Multiscale simulations of critical interfacial failure in carbon nanotube-polymer composites.

J Chem Phys 2018 Dec;149(22):224102

Department of Materials, Imperial College London, London SW7 2AZ, United Kingdom.

Computational investigation of interfacial failure in composite materials is challenging because it is inherently multi-scale: the bond-breaking processes that occur at the covalently bonded interface and initiate failure involve quantum mechanical phenomena, yet the mechanisms by which external stresses are transferred through the matrix occur on length and time scales far in excess of anything that can be simulated quantum mechanically. In this work, we demonstrate and validate an adaptive quantum mechanics (QM)/molecular mechanics simulation method that can be used to address these issues and apply it to study critical failure at a covalently bonded carbon nanotube (CNT)-polymer interface. In this hybrid approach, the majority of the system is simulated with a classical forcefield, while areas of particular interest are identified on-the-fly and atomic forces in those regions are updated based on QM calculations. Read More

View Article
December 2018

Reversible hydrogen adsorption on Li-decorated T-graphene flake: The effect of electric field.

J Mol Graph Model 2018 Dec 8;87:192-196. Epub 2018 Dec 8.

Department of Chemistry, College of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

In the present work, we have studied a new allotrope of graphene, denoted as T-graphene (TG) flake as a versatile material in hydrogen storage. Recently, the metallic character of TG has been revealed. Our results show that the Li-decoration has a significant effect on the electronic properties of TG flake. Read More

View Article
December 2018

Weighted vest effects on impact forces and joint work during vertical jump landings in men and women.

Hum Mov Sci 2018 Dec 12;63:156-163. Epub 2018 Dec 12.

Department of Kinesiology & Nutrition Sciences, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, Box 3034, Las Vegas, NV 89154, USA.

Weighted vest (WV) use during vertical jump landings (VJL) does not appear to alter peak vertical ground reaction forces (GRF) or peak joint torques. However, WV effects on joint work and sex differences during VJL are not well understood. This study assessed WV effects on vertical GRF and sagittal joint work during VJL in men and women. Read More

View Article
December 2018
1 Read

Are parents at a higher risk for secondary traumatic stress?: How interviewing child victims impacts relationships with forensic interviewer's friends and family.

Child Abuse Negl 2018 Dec 12;88:275-287. Epub 2018 Dec 12.

School of Arts & Sciences, University of Houston-Victoria, 3007 N. Ben Wilson, Victoria, TX, 77904, United States. Electronic address:

Background: Forensic interviewers are at a heightened risk for secondary traumatic stress (STS) due to their frequent interactions with victims of child maltreatment (Bonach & Heckert, 2012). To date, however, few studies have examined the negative effects of this work on interviewers' social and emotional well-being.

Objective: The present study seeks to explore the effect of STS on the relationships of forensic interviewers, including those with friends, family, and their respective children. Read More

View Article
December 2018

Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.

Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More

View Article
December 2018

Recommendations for cerebrospinal fluid analysis.

Folia Microbiol (Praha) 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Biophysics and Medical Informatics, 3rd Faculty of Medicine, Charles University, Ruská 87, 100 00, Prague 10, Czech Republic.

Diseases of the central nervous system (CNS) mean for the human organism a potentially dangerous situation. An investigation of cerebrospinal fluid (CSF) provides important information about a character of CNS impairment in the decision-making diagnostic and therapeutic algorithm. The authors present a brief overview of available cerebrospinal fluid assays, shortened indication criteria, a recommended algorithm of CSF assessment in different suspected diseases, and a view of the external quality system. Read More

View Article
December 2018
1 Read

From deep learning to transfer learning for the prediction of skeletal muscle forces.

Authors:
Tien Tuan Dao

Med Biol Eng Comput 2018 Dec 14. Epub 2018 Dec 14.

Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu, Compiègne Cedex, France.

Skeletal muscle forces may be estimated using rigid musculoskeletal models and neural networks. Neural network (NN) approach has the advantages of real-time estimation ability and promising prediction accuracy. However, most of the developed NN models are based on conventional feedforward NNs, which do not take dynamic temporal relationships of the muscle force profiles into consideration. Read More

View Article
December 2018

Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice.

Chin J Integr Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Plastic Surgery, the Third Xiangya Hospital of Central South University, Changsha, 410013, China.

Objective: To investigate the effects of Ganoderma lucidum polysaccharides (GL-PS) on human fifi broblasts and skin wound healing in Kunming male mice and to explore the putative molecular mechanism.

Methods: Primary human skin fifi broblasts were cultured. The viability of fifi broblasts treated with 0, 10, 20, 40, 80, and 160 μg/mL of GL-PS, respectively were detected by 3-4,5-dimethyl-2-thiazolyl-2,5-diphenyl-2-Htetrazolium bromide (MTT). Read More

View Article
December 2018
2 Reads

Pathoanatomy of Maisonneuve fracture based on radiologic and CT examination.

Arch Orthop Trauma Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Orthopaedics, First Faculty of Medicine, Charles University and Military University Hospital Prague, U Vojenské Nemocnice 1200, 169 02, Prague 6, Czech Republic.

Introduction: Although Maisonneuve fracture (MF) is a well-known type of ankle fracture-dislocation, there is still a lack of information about the epidemiology and the extent of all associated injuries. The aim of study is to describe MF pathoanatomy on the basis of radiographs, CT scans and intraoperative findings.

Materials And Methods: The study comprised 54 adult patients. Read More

View Article
December 2018

A note on evolution of pressure and flow within an evaporating capillary bridge.

Eur Phys J E Soft Matter 2018 Dec 5;41(12):140. Epub 2018 Dec 5.

Duke University, Mechanical Engineering and Materials Science Dept., Durham, NC, USA.

Experiments with evaporation of capillary bridges between two glass spheres show that the bridge gorge radius decreases much faster than the contact radius, distorting the original constant mean curvature bridge shape. In addition, the Laplace pressure calculated from local principal curvatures exhibits high gradients along the bridge moving external surface, most commonly with a high suction near the triple phase contact and positive pressure near the gorge. The high suction results from a negative external curvature at contact. Read More

View Article
December 2018
1 Read

Using the zygomatic arch as a reference line for clinical applications and anthropological studies.

Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.

Department of Anatomy, Research Institute of Medical Science, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.

Purpose: The Frankfurt line is the most frequently and widely used reference line in cephalometric analysis, but has shortcomings including the difficulty of landmark identification. This study investigated using the superior border of the zygomatic arch as a new external bony landmark, including measuring the angle between the new reference line and the Frankfurt line.

Methods: Facial computed tomography scans were obtained from 170 patients (100 males and 70 females) hospitalized at Konkuk University Chungju Hospital. Read More

View Article
December 2018

Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study.

Sci Rep 2018 Dec 14;8(1):17867. Epub 2018 Dec 14.

Department of Bioengineering, Medicine & Radiology, University of California, San Diego, CA, USA.

Despite the importance of pelvic floor muscles, significant controversy still exists about the true structural details of these muscles. We provide an objective analysis of the architecture and orientation of the superficial muscles of the perineum using a novel approach. Magnetic Resonance Diffusion Tensor Images (MR-DTI) were acquired in 10 healthy asymptomatic nulliparous women, and 4 healthy males. Read More

View Article
December 2018
1 Read

Evaluation of stakeholder views on peer review of NIHR applications for funding: a qualitative study.

BMJ Open 2018 Dec 14;8(12):e022548. Epub 2018 Dec 14.

Wessex Institute, University of Southampton, Southampton, UK.

Objectives: Innovations resulting from research have both national and global impact, so selecting the most promising research studies to fund is crucial. Peer review of research funding applications is part of the selection process, and requires considerable resources. This study aimed to elicit stakeholder opinions about which factors contribute to and influence effective peer review of funding applications to the UK National Institute for Health Research (NIHR), and to identify possible minor improvements to current processes and any major changes or potential innovations to achieve a more efficient peer review process. Read More

View Article
December 2018

Influence of external peer reviewer scores for funding applications on funding board decisions: a retrospective analysis of 1561 reviews.

BMJ Open 2018 Dec 14;8(12):e022547. Epub 2018 Dec 14.

Wessex Institute, Faculty of Medicine, University of Southampton, Southampton, UK.

Objectives: To evaluate the influence of external peer reviewer scores on the National Institute for Health Research (NIHR) research funding board decisions by the number of reviewers and type of reviewer expertise.

Design: Retrospective analysis of external peer review scores for shortlisted full applications for funding (280 funding applications, 1236 individual reviewers, 1561 review scores).

Setting: Four applied health research funding programmes of NIHR, UK. Read More

View Article
December 2018

Molecular characterization of LysPBC2, a novel endolysin harboring a spore binding domain.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul 08826, South Korea

To control a spore-forming human pathogen , we isolated and characterized a novel endolysin, LysPBC2, from a newly isolated phage PBC2. Compared to the narrow host range of phage PBC2, LysPBC2 showed very broad lytic activity against all , , and species tested. In addition to a catalytic domain and a cell wall binding domain, LysPBC2 has a spore binding domain (SBD) partially overlapped with its catalytic domain, which specifically binds to spores but not to vegetative cells of Both immunogold electron microscopy and binding assay indicate that the SBD binds the external region of the spore cortex layer. Read More

View Article
December 2018
1 Read

The emerging field of epigenetics and its relevance for the physiotherapy profession.

J Physiother 2018 Dec 11. Epub 2018 Dec 11.

Pain in Motion international research group; Department of Physiotherapy, Human Physiology and Anatomy, Free University Brussels, Belgium; Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Belgium.

View Article
December 2018
1 Read

Upper Extremity Care for Children: Unique Medical and Psychosocial Aspects.

Authors:
Sonia Chaudhry

J Hand Surg Am 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatric Orthopaedic and Hand Surgery, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, CT. Electronic address:

Hand surgeons encountering pediatric patients should be attuned to both technical and practical facets of caring for congenital and traumatic pathologies. Psychosocial aspects include engaging children in conversation and factoring in both self and external perception of deformity. Medical considerations are also unique, from including child abuse in the differential to having techniques to assess active motion and sensation in the nonverbal child. Read More

View Article
December 2018

Modified external fixator in pediatric multilevel noncontiguous cervical spinal fracture dislocation: A case report.

J Orthop Sci 2018 Dec 11. Epub 2018 Dec 11.

Orthopedics and Trauma Surgery Department of Grand-Yoff General Hospital, Cheikh Anta Diop University of Dakar, Senegal.

View Article
December 2018

[Exploring illness perceptions of lupus patients for a motivational environment in therapeutic education].

Rev Med Interne 2018 Dec 11. Epub 2018 Dec 11.

Service de médecine interne, Centre de référence des maladies auto-immunes systémiques rares, hôpital Huriez, CHU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France.

Purpose: Therapeutic education (TE) intends to help patients with systemic lupus erythematosus to better understand their disease and to improve their quality of life. The objective of this study was to assess illness perceptions of the person to provide a motivational environment for TE.

Methods: Systemic lupus erythematosus patients followed in the department of internal medicine in Lille university hospital responded to a questionnaire assessing five dimensions of the person as proposed by Giordan: the cognitive (knowledge), perceptual (fatigue and pain), affective (anxious and depressive symptoms), infra-cognitive (intimate reasoning) and metacognitive (worldview) dimensions. Read More

View Article
December 2018

National patterns of care and cancer-specific outcomes of adjuvant treatment in patients with serous and clear cell endometrial carcinoma.

Gynecol Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, Stanford University, Stanford, CA, United States of America. Electronic address:

Objectives: To investigate outcomes of adjuvant therapy for serous and clear cell endometrial carcinoma, as prior studies are limited by sample size and/or patient heterogeneity. National guidelines permit substantial variations in treatment, suggesting the need for additional data.

Methods: Patients with FIGO stages I-III serous or clear cell uterine carcinoma who underwent at least total hysterectomy were identified in SEER-Medicare. Read More

View Article
December 2018

Palliation of dysphagia.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:97-103. Epub 2018 Nov 22.

Department of Gastroenterology & Hepatology, Erasmus MC University Medical Centre, Rotterdam, the Netherlands. Electronic address:

Palliation of dysphagia is the cornerstone of palliative treatment in patients with incurable oesophageal cancer. Available palliative options for dysphagia are oesophageal stent placement and radiotherapy. In general, oesophageal stent placement is the preferred therapeutic option in patients with a relatively poor prognosis because of its rapid relief of dysphagia. Read More

View Article
November 2018

Dosimetric comparison of vaginal vault brachytherapy vs applicator-guided stereotactic body radiotherapy with volumetric modulated arc therapy and helical tomotherapy for endometrium cancer patients.

Med Dosim 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, Baskent University Faculty of Medicine, 01120 Adana, Turkey. Electronic address:

We performed this dosimetric study to compare a nonstandard volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT) techniques with high-dose rate (HDR) brachytherapy (BRT) plan of vaginal vault in patients with postoperative endometrial cancer (EC). Twelve postoperative patients with early stage EC were included in this study. Three plans were performed for each patient; dosimetric and radiobiological comparisons were made using dose-volume histograms and equivalent dose for determining the planning target volume (PTV) coverages in brachytherapy and external beam radiotherapy, and organs-at-risk (OARs) doses between three different delivery techniques. Read More

View Article
December 2018
1 Read

Self-Calibration and Performance Control of MEMS with Applications for IoT.

Authors:
Jason Clark

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

Electrical and Computer Engineering, Auburn University, Auburn, AL 36830, USA.

A systemic problem for microelectromechanical systems (MEMS) has been the large gap between their predicted and actual performances. Due to process variations, no two MEMS have been able to perform identically. In-factory calibration is often required, which can represent as much as three-fourths of the manufacturing costs. Read More

View Article
December 2018

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery.

Colloids Surf B Biointerfaces 2019 Jan 27;173:842-850. Epub 2018 Oct 27.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address:

Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media. Read More

View Article
January 2019

Light-induced mechanisms for nanocarrier's cargo release.

Colloids Surf B Biointerfaces 2019 Jan 25;173:825-832. Epub 2018 Oct 25.

Nanobiotechnology for diagnostics group (Nb4D), Department of Chemical and Biomolecular Nanotechnology, Institute for Advanced Chemistry of Catalonia (IQAC) of the Spanish Council for Scientific Research (CSIC), Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Jordi Girona 18-26, 08034 Barcelona, Spain.

Nanomaterials have been the focus of attention in several fields, including biomedicine, electronics, or catalysis, mainly due to the novel properties of the materials at the nanoscale. In the field of diagnosis, nanomaterials have been contemplated as an opportunity to improve sensitivity and time of response, therefore, facilitating early treatment and monitoring of the disease. For therapeutic applications, new drug delivery nanosystems aiming to provide enhanced efficiency have been proposed often addressing selective or controlled delivery of therapeutic agents to particular cells to maximize treatment efficacy minimizing adverse effects. Read More

View Article
January 2019
1 Read

A decision tree-based integrated testing strategy for tailor-made carcinogenicity evaluation of test substances using genotoxicity test results and chemical spaces.

Mutagenesis 2018 Dec 14. Epub 2018 Dec 14.

R&D, Safety Science Research, Kao Corporation, Ichikai-Machi, Haga-Gun, Tochigi, Japan.

Genotoxicity evaluation has been widely used to estimate the carcinogenicity of test substances during safety evaluation. However, the latest strategies using genotoxicity tests give more weight to sensitivity; therefore, their accuracy has been very low. For precise carcinogenicity evaluation, we attempted to establish an integrated testing strategy for the tailor-made carcinogenicity evaluation of test materials, considering the relationships among genotoxicity test results (Ames, in vitro mammalian genotoxicity and in vivo micronucleus), carcinogenicity test results and chemical properties (molecular weight, logKow and 179 organic functional groups). Read More

View Article
December 2018
1 Read

Why do current strategies for optimal nutritional therapy neglect the microbiome?

Nutrition 2018 Oct 5;60:100-105. Epub 2018 Oct 5.

Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA.

Strategies for providing optimal nutritional therapy have evolved over time, with the emphasis on specific directives (such as route, use of immunonutrition, high protein, organ-specific formulas, etc.), achieving variable degrees of success for improving outcomes in the intensive care unit. As the largest immune organ in the body comprising the largest interface between the host and the external environment, the gut can have an amplifying effect on a pattern of dysbiosis, immune dysregulation, and multiple organ failure seen in the critically ill patient. Read More

View Article
October 2018
6 Reads

Promoting opioid overdose prevention and recovery: An exploratory study of an innovative intervention model to address opioid abuse.

Int J Drug Policy 2018 Dec 11;64:21-29. Epub 2018 Dec 11.

NJ Division of Mental Health and Addiction Services, Office of Planning, Research, Evaluation and Prevention, 222 South Warren Street, Trenton, NJ 08625-0700, United States. Electronic address:

Background: Fatal opioid overdose is a national public health concern in the United States and a critical problem confronting New Jersey's addiction treatment system. New Jersey developed an innovative program, the Opioid Overdose Recovery Program (OORP), to address the epidemic and the issue of low treatment admissions following a non-fatal overdose. The OORP utilizes an intervention model with peer recovery specialists (RSs) and patient navigators (PNs) to engage individuals within emergency departments (EDs) immediately following an opioid overdose reversal. Read More

View Article
December 2018

Integrated chemical exposure assessment of coastal green turtle foraging grounds on the Great Barrier Reef.

Sci Total Environ 2018 Nov 22;657:401-409. Epub 2018 Nov 22.

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall St, Woolloongabba, Qld 4102, Australia.

The Great Barrier Reef receives run-off from 424,000 km catchment area across coastal Queensland, incorporating diffuse agricultural run-off, and run-off point sources of land-based chemical pollutants from urban and industrial development. Marine biota, such as green turtles (Chelonia mydas), are exposed to these diverse chemical mixtures in their natural environments, and the long term effects on turtle and ecosystem health remain unknown. This study was part of a larger multi-disciplinary project characterising anthropogenic chemical exposures from the marine environment and turtle health. Read More

View Article
November 2018

Is ventromedial prefrontal cortex critical for behavior change without external reinforcement?

Neuropsychologia 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurobiology, The Faculty of Life Sciences, Tel Aviv University; Sagol School of Neuroscience, Tel Aviv University, Israel.

Cue-approach training (CAT) is a novel paradigm that has been shown to induce preference changes towards items without external reinforcements. In the task, the mere association of a neutral cue and a speeded button response has been shown to induce a behavioral choice preference change lasting for months. This paradigm includes several phases: after the training of individual items, behavior change is manifested in binary choices of items with similar initial values. Read More

View Article
December 2018

Unbiased Measurement of Phosphate and Phosphorus Speciation in Surface Waters.

Environ Sci Technol 2018 Dec 14. Epub 2018 Dec 14.

Trace-level phosphate analysis and phosphorus speciation in surface water remained challenging due to adsorption and phosphate uptake by microorganisms. In this study a two-dimensional ion chromatography separation coupled to electrospray ionization high-resolution mass spectrometry (2D-IC-ESI-MS) allowed isotope dilution quantitation of phosphate with simultaneous analysis of eleven phosphate-containing metabolites and two inorganic condensed phosphates. Samples were collected from Lake St. Read More

View Article
December 2018

Dosimetric effects of the kV based image-guided radiation therapy of prone breast external beam radiation: Towards the optimized imaging frequency.

J Appl Clin Med Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Purpose: For prone breast treatment, daily image-guided radiation therapy (IGRT) allows couch shifting to correct breast position relative to the treatment field. This work investigates the dosimetric effect of reducing kV imaging frequencies and the feasibility of optimizing the frequency using patient anatomy or their first 3-day shifts.

Method: Thirty-seven prone breast patients who had been treated with skin marker alignment followed by daily kV were retrospectively analyzed. Read More

View Article
December 2018
2 Reads

Strategies in scheduling marine protected area establishment in a network system.

Ecol Appl 2018 Dec 14. Epub 2018 Dec 14.

ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, Queensland, Australia.

Instantaneous implementation of systematic conservation plans at regional scales is rare. More typically, planned actions are applied incrementally over periods of years or decades. During protracted implementation, the character of the connected ecological system will change as a function of external anthropogenic pressures, local metapopulation processes, and environmental fluctuations. Read More

View Article
December 2018
2 Reads