1,858 results match your criteria Expert opinion on therapeutic targets[Journal]


TIPE2 as a potential therapeutic target in chronic viral hepatitis.

Expert Opin Ther Targets 2019 Apr 17. Epub 2019 Apr 17.

a Department of Hepatology , Qilu Hospital of Shandong University , Jinan , China.

Introduction: Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative regulator of innate and adaptive immune responses by binding to caspase-8. The binding of TIPE2 and caspase-8 can inhibit the activity of activating protein-1(AP-1) and nuclear factor-κB (NF-κB), ultimately promoting Fas-induced apoptosis in immune cells. Therefore, TIPE2-caspase-8-NF-κB signaling might serve as a biomarker and a potential target for therapeutic intervention. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1608948DOI Listing
April 2019
1 Read

Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.

Expert Opin Ther Targets 2019 Apr 16. Epub 2019 Apr 16.

a Indiana Center for Liver Research, Division of Gastroenterology & Hepatology, Department of Medicine , Indiana University School of Medicine , Indianapolis , Indiana , USA.

Introduction The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is only option. An understanding of the mechanisms and pathogenesis is needed to develop novel therapies. Read More

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http://dx.doi.org/10.1080/14728222.2019.1608950DOI Listing
April 2019
1 Read

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma.

Expert Opin Ther Targets 2019 Apr 15:1-14. Epub 2019 Apr 15.

a Institute of Pathology , Medical University of Graz , Graz , Austria.

Introduction: Protein sequestosome 1/p62 (p62) plays a crucial role in vital complex and interacting signaling pathways in normal and neoplastic cells. P62 is involved in autophagy, defense against oxidative stress via activation of the Keap1/Nrf2 system, in protein aggregation and sequestration, and in apoptosis. Autophagy contributes to cell survival and proliferation by eliminating damaged organelles, potentially toxic protein aggregates and invading microorganisms, and by providing nutrients under starvation conditions. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1601703DOI Listing
April 2019
1 Read

The potential of dopamine receptor 2 (DRD2) as a therapeutic target for tackling pancreatic cancer.

Expert Opin Ther Targets 2019 Apr 15. Epub 2019 Apr 15.

a Department of Human Genetics , McGill University , 1205 Doctor Penfield Avenue, Montreal , QC , H3A 1B1 , Canada.

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http://dx.doi.org/10.1080/14728222.2019.1606904DOI Listing

Therapeutic approaches for targeting ROR-1 in cancer cells.

Expert Opin Ther Targets 2019 Apr 1. Epub 2019 Apr 1.

d Stem Cell Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Introduction: There is a high expression of ROR1, a tyrosine kinase receptor, in various tumor-cell types. ROR1 is involved in many key processes in cancer including proliferation, survival and metastasis. Hence, ROR1 is an attractive and promising therapeutic target. Read More

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http://dx.doi.org/10.1080/14728222.2019.1602608DOI Listing
April 2019
1 Read

TANK-binding kinase 1 as a novel therapeutic target for viral diseases.

Expert Opin Ther Targets 2019 Apr 1:1-10. Epub 2019 Apr 1.

a Department of Immunology, School of Basic Medical Science , Shandong University , Jinan , China.

Introduction: TANK-binding kinase 1 (TBK1) is vital for the induction of antiviral innate immune responses. Both RNA and DNA viral infection induces TBK1 activation, triggers phosphorylation of interferon regulatory factor (IRF) 3 and subsequent expression of type I interferons (IFNs; IFN-α/β). Type I IFNs can induce the expression of numerous antiviral genes called interferon-stimulated genes (ISGs) to build a remarkable antiviral state and limit viral replication. Read More

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http://dx.doi.org/10.1080/14728222.2019.1601702DOI Listing
April 2019
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Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.

Expert Opin Ther Targets 2019 Mar 31:1-9. Epub 2019 Mar 31.

a Department of Urology , Tokyo Medical and Dental University , Tokyo , Japan.

Introduction: The heat shock factor 1 (HSF1) plays a pivotal role in guarding proteome stability or proteostasis by induction of heat shock proteins (HSPs). While HSF1 remains mostly latent in unstressed normal cells, it is constitutively active in malignant cells, rendering them addicted to HSF1 for their growth and survival. HSF1 affects tumorigenesis, cancer progression, and treatment resistance by preserving cancer proteostasis, thus suggesting disruption of HSF1 activity as a potential anticancer strategy. Read More

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http://dx.doi.org/10.1080/14728222.2019.1602119DOI Listing
March 2019
3 Reads

Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases.

Expert Opin Ther Targets 2019 Mar 27:1-14. Epub 2019 Mar 27.

b School of Chinese Medicine , The University of Hong Kong , Hong Kong , China.

Introduction: Cardiovascular diseases are the leading cause of human death globally. Lipid mediators contribute to the initiation and resolution of inflammation in the pathogenesis of cardiovascular diseases. These resolving lipid mediators antagonize the effects of pro-inflammatory prostaglandins (PGs) and leukotrienes (LTs) on macrophage/neutrophil infiltration, enhance macrophage phagocytosis towards apoptotic cells, and accelerate tissue repair. Read More

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http://dx.doi.org/10.1080/14728222.2019.1599360DOI Listing

Hepcidin as a therapeutic target for anemia and inflammation associated with chronic kidney disease.

Expert Opin Ther Targets 2019 Mar 24:1-15. Epub 2019 Mar 24.

a Department of Nephrology, Dialysis and Internal Medicine , Warsaw Medical University , Warsaw , Poland.

Introduction: Anemia is a common manifestation of chronic kidney disease (CKD). The pathogenesis of CKD-associated anemia is multifactorial. Our understanding of the molecular control of iron metabolism has improved dramatically because of the discovery of hepcidin and attempts to introduce new drugs to stimulate erythropoiesis or affect the hepcidin-ferroportin pathway have recently emerged. Read More

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http://dx.doi.org/10.1080/14728222.2019.1599358DOI Listing
March 2019
5 Reads

Opportunities for future therapeutic interventions for hyperoxaluria: targeting oxidative stress.

Expert Opin Ther Targets 2019 Mar 25:1-13. Epub 2019 Mar 25.

a Department of Pathology, Immunology & Laboratory Medicine, College of Medicine , University of Florida , Gainesville , FL , USA.

Introduction: Oxalate is a toxic byproduct of metabolism and is normally produced in quantities easily removed from the body. However, under specific circumstances oxalate production is increased resulting in deposition of calcium oxalate (CaOx) crystals in the kidneys as well as other organs causing inflammation and injury. Excessive buildup of crystal deposits in the kidneys causes eventual loss of renal function requiring renal transplantation. Read More

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http://dx.doi.org/10.1080/14728222.2019.1599359DOI Listing
March 2019
1 Read

Th17 cells: a promising therapeutic target for Parkinson's disease?

Expert Opin Ther Targets 2019 Apr 14;23(4):309-314. Epub 2019 Mar 14.

a Department of Stem Cell Biology , Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg , Erlangen , Germany.

Introduction: Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused by the progressive loss of neurons in the midbrain and other brain regions. Only symptomatic treatment is currently available. Mounting evidence suggests that T cells are a key contributor to PD pathogenesis and neurodegeneration by a mechanism that requires further elucidation. Read More

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http://dx.doi.org/10.1080/14728222.2019.1590336DOI Listing
April 2019
2 Reads

Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target.

Expert Opin Ther Targets 2019 Apr 19;23(4):295-307. Epub 2019 Mar 19.

a Division for Molecular Internal Medicine, Department of Internal Medicine II , University Hospital Würzburg , Würzburg , Germany.

Introduction: Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities. TNFR2 has proinflammatory effects too, but it also elicits strong anti-inflammatory activities and has protective effects on oligodendrocytes, cardiomyocytes, and keratinocytes. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1586886DOI Listing
April 2019
8 Reads

The emergence of Ephexin5 as a therapeutic target in Alzheimer's disease.

Expert Opin Ther Targets 2019 Apr 5;23(4):263-265. Epub 2019 Mar 5.

a Department of Biological Chemistry , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/14728222.2019.1586884DOI Listing
April 2019
1 Read

Current strategies toward safer mu opioid receptor drugs for pain management.

Expert Opin Ther Targets 2019 Apr 15;23(4):315-326. Epub 2019 Mar 15.

a Department of Psychiatry , McGill University, Douglas Hospital Research Center , Montréal , QC , Canada.

Introduction: Pain relief remains a major public health challenge. The most efficient available painkillers are opioids targeting the mu opioid receptor (MOR). MORs are expressed in the areas of the brain [including pain and respiratory centers] that are important for processing reward and aversion. Read More

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http://dx.doi.org/10.1080/14728222.2019.1586882DOI Listing

The use of LP533401 as a therapeutic option for renal osteodystrophy affects, renal calcium handling, vitamin D metabolism, and bone health in uremic rats.

Expert Opin Ther Targets 2019 Apr 12;23(4):353-364. Epub 2019 Mar 12.

b Department of Monitored Pharmacotherapy , Medical University of Bialystok , Bialystok , Poland.

Background: Klotho is a key regulator of phosphate and Ca-transport in the kidney. Recently, we showed that treatment with LP533401 improved bone health in rats with chronic kidney disease (CKD) via the normalization of serum phosphate resulting from the reduced renal expression of phosphate cotransporters, including Klotho.

Methods: We evaluated the effect of LP533401 therapy on Klotho-expression-dependent Ca-transporters, renal calcium handling, and the potential consequences for the bone of uremic rats. Read More

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http://dx.doi.org/10.1080/14728222.2019.1586883DOI Listing

Targeting metabotropic glutamate receptors in the treatment of epilepsy: rationale and current status.

Expert Opin Ther Targets 2019 Apr 21;23(4):341-351. Epub 2019 Mar 21.

a IRCCS NEUROMED , Pozzilli , Italy.

Introduction: Several drugs targeting the GABAergic system are used in the treatment of epilepsy, but only one drug targeting glutamate receptors is on the market. This is surprising because an imbalance between excitatory and inhibitory neurotransmission lies at the core of the pathophysiology of epilepsy. One possible explanation is that drug development has been directed towards the synthesis of molecules that inhibit the activity of ionotropic glutamate receptors. Read More

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http://dx.doi.org/10.1080/14728222.2019.1586885DOI Listing
April 2019
5.139 Impact Factor

Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape.

Expert Opin Ther Targets 2019 Apr 22;23(4):327-339. Epub 2019 Feb 22.

a Neuroscience Graduate Program , McMaster University , Hamilton , ON , Canada.

Introduction: Present antidepressant treatments are only helpful in a quarter of patients with bipolar depression, and new strategies are warranted. Increasing evidence suggests that accelerated polyamine metabolism is associated with the pathophysiology of depression. Polyamines regulate stress responses, inflammation, and neuronal signaling in the central and enteric nervous system. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1581764DOI Listing
April 2019
4 Reads

Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview.

Expert Opin Ther Targets 2019 Apr 26;23(4):267-280. Epub 2019 Feb 26.

a Department of Pathology , University of Colorado Denver, Anschutz Medical Campus , Aurora , CO , USA.

Introduction: Epigenetic mechanisms of gene regulatory control play fundamental roles in developmental morphogenesis, and, as more recently appreciated, are heavily implicated in the onset and progression of neoplastic disease, including cancer. Many epigenetic mechanisms are therapeutically targetable, providing additional incentive for understanding of their contribution to cancer and other types of neoplasia. Areas covered: The Jumonji-domain histone demethylase (JHDM) family exemplifies many of the above traits. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1580692DOI Listing
April 2019
4 Reads

The NKG2D axis: an emerging target in cancer immunotherapy.

Expert Opin Ther Targets 2019 Apr 22;23(4):281-294. Epub 2019 Feb 22.

a Institute for Molecular Medicine , Goethe-University Frankfurt am Main , Frankfurt am Main , Germany.

Introduction: The immunoreceptor NKG2D belongs to the best-characterized activating receptors of cytotoxic lymphocytes. NKG2D binds to a variety of cell surface glycoproteins distantly related to MHC class I molecules, termed NKG2D ligands (NKG2DL). NKG2DL are inducibly expressed upon cellular stress, viral infection or malignant transformation thus marking 'stressed' or 'harmful' cells for clearance through NKG2D lymphocytes. Read More

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http://dx.doi.org/10.1080/14728222.2019.1580693DOI Listing

E2F1 as a molecular drug target in ovarian cancer.

Expert Opin Ther Targets 2019 Mar 8;23(3):161-164. Epub 2019 Feb 8.

a Department of Life Sciences , Cattinara University Hospital, Trieste University , Trieste , Italy.

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http://dx.doi.org/10.1080/14728222.2019.1579797DOI Listing

GRK2 and GRK5 as therapeutic targets and their role in maladaptive and pathological cardiac hypertrophy.

Expert Opin Ther Targets 2019 Mar 13;23(3):201-214. Epub 2019 Feb 13.

a Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.

Introduction: One in every four deaths in the United States is attributed to cardiovascular disease, hence the development and employment of novel and effective therapeutics are necessary to improve the quality of life and survival of affected patient. Pathological hypertrophy is a maladaptive response by the heart to relieve wall stress that could result from cardiovascular disease. Maladaptive hypertrophy can lead to further disease progression and complications such as heart failure; hence, efforts to target hypertrophy to prevent and treat further morbidity and mortality are necessary. Read More

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http://dx.doi.org/10.1080/14728222.2019.1575363DOI Listing

Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable.

Expert Opin Ther Targets 2019 Mar 13;23(3):251-261. Epub 2019 Feb 13.

a Integrative Parasitology, Department of Infectious Diseases , University of Heidelberg Medical School , Heidelberg , Germany.

Background: Cellular metabolism generates reactive oxygen species. The oxidation and deamination of the deoxynucleoside triphosphate (dNTP) pool results in the formation of non-canonical, toxic dNTPs that can cause mutations, genome instability, and cell death. House-cleaning or sanitation enzymes that break down and detoxify non-canonical nucleotides play major protective roles in nucleotide metabolism and constitute key drug targets for cancer and various pathogens. Read More

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http://dx.doi.org/10.1080/14728222.2019.1575810DOI Listing

The P2X7 receptor: a new therapeutic target in Alzheimer's disease.

Expert Opin Ther Targets 2019 Mar;23(3):165-176

b Acupuncture and Tuina School , Chengdu University of TCM , Chengdu , China.

Introduction: Alzheimer's disease (AD) is a neurodegenerative illness with genetic risk as an etiological factor in a subset of cases. In AD with autosomal dominant inheritance, the extracellular β-amyloid (Aβ) aggregates and intracellular neurofibrillary tangles which consist of hyperphosphorylated tau, appear to be involved in the neuronal damage; however, other forms of AD may have a polygenetic causality. Microglial cells orchestrate pathophysiological events responsible for neuronal damage in AD. Read More

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http://dx.doi.org/10.1080/14728222.2019.1575811DOI Listing
March 2019
2 Reads

Involvement of long non-coding RNA HULC (highly up-regulated in liver cancer) in pathogenesis and implications for therapeutic intervention.

Expert Opin Ther Targets 2019 Mar 24;23(3):177-186. Epub 2019 Jan 24.

a Division of Oncology, Department of Internal Medicine , Medical University of Graz (MUG) , Graz , Austria.

Introduction: HULC (highly upregulated in liver cancer) is a long non-coding RNA (lncRNA) which is, as its name suggests, highly upregulated in hepatocellular carcinoma and in several other cancers. Increased HULC expression levels are strongly associated with clinicopathologic features such as tumor stages and overall survival and is a driver of tumor proliferation, migration, and invasion. Areas covered: This review addresses the discovery of HULC and discusses the consequences of HULC deregulation in cancer, the underlying molecular mechanisms and the potential of HULC as a biomarker and therapeutic target. Read More

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http://dx.doi.org/10.1080/14728222.2019.1570499DOI Listing
March 2019
1 Read

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem.

Expert Opin Ther Targets 2019 Mar 12;23(3):227-239. Epub 2019 Feb 12.

a Department of Behavioral Neurogenomics , Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science , Novosibirsk , Russia.

Introduction: Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are known as principal players in different kinds of plasticity. The 5-HT-BDNF interaction in early ontogeny and in adult brain is an intriguing problem. Area covered: This paper concentrates on the interaction between 5-HT and BDNF systems and its implication in different plasticity levels, from neurons to behavior. Read More

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http://dx.doi.org/10.1080/14728222.2019.1572747DOI Listing
March 2019
12 Reads

The MAP kinase-interacting kinases (MNKs) as targets in oncology.

Expert Opin Ther Targets 2019 Mar 24;23(3):187-199. Epub 2019 Jan 24.

a Nutrition & Metabolism , South Australian Health & Medical Research Institute , Adelaide , Australia.

Introduction: The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are switched on by the oncogenic MAPK (ERK) signalling pathway. They phosphorylate eukaryotic initiation factor (eIF) 4E, a protein which recruits ribosomes to mRNAs and thereby mediates their translation. Importantly, overexpression of eIF4E can transform cells, and its function is controlled by a second oncogenic pathway, mechanistic target of rapamycin complex 1. Read More

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http://dx.doi.org/10.1080/14728222.2019.1571043DOI Listing
March 2019
3 Reads

Pro- and Anti-Tumorigenic Functions of the Senescence-Associated Secretory Phenotype.

Expert Opin Ther Targets 2019 Jan 8. Epub 2019 Jan 8.

a Department of Biochemistry and Molecular Pharmacology , New York University School of Medicine , New York , NY , USA.

Introduction: Cellular senescence is a stable form of cell-cycle exit. Though they no longer divide, senescent cells remain metabolically active and secrete a plethora of proteins collectively termed the senescence-associated secretory phenotype (SASP). Although senescence-associated cell-cycle exit likely evolved as an anti-tumor mechanism, the SASP contains both anti- and pro-tumorigenic potential. Read More

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http://dx.doi.org/10.1080/14728222.2019.1565658DOI Listing
January 2019
1 Read

Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases.

Expert Opin Ther Targets 2019 Feb 24;23(2):117-126. Epub 2018 Dec 24.

a Instituto de Investigaciones Biomédicas (INBIOMED, UBA-CONICET), Facultad de Medicina , Universidad de Buenos Aires , Buenos Aires , Argentina.

Introduction: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role in the cellular stress response. The first reported and better characterized MDP is humanin (HN), which exerts robust protective effects against a myriad of cytotoxic stimuli in many cell types. Read More

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http://dx.doi.org/10.1080/14728222.2019.1559300DOI Listing
February 2019
3 Reads

Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise.

Expert Opin Ther Targets 2019 Feb 22;23(2):153-160. Epub 2018 Dec 22.

b Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS , Rome , Italy.

Introduction: Mitochondrial dysfunction is a hallmark of aging and hence is a candidate target for intervention. Sarcopenia of aging is a prevalent condition and is associated with numerous negative health outcomes. Alterations in mitochondrial homeostasis have been reported in sarcopenic muscle. Read More

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http://dx.doi.org/10.1080/14728222.2019.1559827DOI Listing
February 2019
2 Reads

The farnesoid X receptor: a potential target for expanding the therapeutic arsenal against kidney disease.

Expert Opin Ther Targets 2019 Feb 26;23(2):107-116. Epub 2018 Dec 26.

a First Department of Pathology, Medical School , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Farnesoid X receptor (FXR) is a nuclear bile acid (BA) receptor widely distributed among tissues, a major sensor of BA levels, primary suppressor of hepatic BA synthesis and secondary regulator of lipid metabolism and inflammation. Chronic kidney disease is a common, multifactorial condition with metabolic and inflammatory causes and implications. An array of natural and synthetic FXR agonists has been developed, but not yet studied clinically in kidney disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1559825DOI Listing
February 2019
2 Reads

Therapeutic relevance of SOX9 stem cell factor in gastric cancer.

Expert Opin Ther Targets 2019 Feb 20;23(2):143-152. Epub 2018 Dec 20.

a Cellular Oncology group , Biodonostia Health Research Institute , San Sebastian , Spain.

Introduction: Recent comprehensive genetic and molecular profiling has identified molecular subtypes of gastric cancer (GC) and has linked them to clinical information. Moreover, SOX9 has been recently described as a relevant regulator of the population of GC stem cells (gCSCs), which are responsible for GC initiation and progression. Areas covered: Through public data from The Cancer Genome Atlas (TCGA) project, the Asian Cancer Research Group (ACRG) and published studies, we link SOX9 expression to GC clinical information and molecular subtypes. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1559826DOI Listing
February 2019
10 Reads
5.139 Impact Factor

The apelin/APJ system as a therapeutic target in metabolic diseases.

Expert Opin Ther Targets 2019 Mar 10;23(3):215-225. Epub 2019 Jan 10.

a Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), INSERM U1048 , Université de Toulouse , Toulouse , France.

Introduction: Apelin, a bioactive peptide, is the endogenous ligand of APJ, a G protein-coupled receptor which is widely expressed in peripheral tissues and in the central nervous system. The apelin/APJ system is involved in the regulation of various physiological functions and is a therapeutic target in different pathologies; the development of APJ agonists and antagonists has thus increased. Area covered: This review focuses on the in vitro and in vivo metabolic effects of apelin in physiological conditions and in the context of metabolic diseases. Read More

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http://dx.doi.org/10.1080/14728222.2019.1561871DOI Listing
March 2019
1 Read

AdipoRs- a potential therapeutic target for fibrotic disorders.

Expert Opin Ther Targets 2018 Dec 20:1-14. Epub 2018 Dec 20.

b Department of Medicinal Chemistry, School of Pharmacy , China Pharmaceutical University , Nanjing , China.

Introduction: Fibrotic disorders are a leading cause of morbidity and mortality; hence effective treatments are still vigorously sought. AdipoRs (AdipoR1 and Adipo2) are responsible for the antifibrotic effects of adiponectin (APN). APN exerts antifibrotic effects by binding to its receptors. Read More

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http://dx.doi.org/10.1080/14728222.2019.1559823DOI Listing
December 2018
1 Read

Rationale for co-targeting CDK4/6 and FGFR pathways in urothelial carcinoma.

Expert Opin Ther Targets 2018 Dec 17:1-4. Epub 2018 Dec 17.

b Division of Hematology and Medical Oncology, Department of Medicine , Weill Cornell Medical College , New York , NY , USA.

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http://dx.doi.org/10.1080/14728222.2019.1559828DOI Listing
December 2018
2 Reads
5.139 Impact Factor

Targeting Hedgehog pathway in pediatric acute myeloid leukemia: challenges and opportunities.

Expert Opin Ther Targets 2019 Feb 24;23(2):87-91. Epub 2018 Dec 24.

a Department of Pediatrics, "Lalla Seràgnoli", Hematology-Oncology Unit , University of Bologna , Bologna , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1559822DOI Listing
February 2019
18 Reads

CD73 as a potential opportunity for cancer immunotherapy.

Expert Opin Ther Targets 2019 Feb 26;23(2):127-142. Epub 2018 Dec 26.

i Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Introduction: Cancer cells apply various mechanisms to induce and enhance immune escape. The complex network of immune-response modulating factors in the tumor microenvironment is a reason for the difficulties encountered when attempting to treat many cancers. Adenosine is a potent immune-modulating factor that can be generated through the degradation of ATP by cooperative action of NTPDase1 (CD39) and ecto-5'-nucleotidase (CD73) molecules. Read More

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http://dx.doi.org/10.1080/14728222.2019.1559829DOI Listing
February 2019
2 Reads

Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung.

Expert Opin Ther Targets 2019 Mar 27;23(3):241-250. Epub 2018 Dec 27.

a Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Introduction: Kelch-like ECH associated protein 1/Nuclear factor erythroid 2-like factor 2 (Keap1-Nrf2) signaling plays a pivotal role in response to oxidative stress in lung cancer. Mutations in KEAP1/NFE2L2 genes always cause persistent Nrf2 activation in lung cancer cells that confer therapeutic resistance and aggressive tumorigenic activity, dictating either poor prognosis or short duration of response to chemotherapy in clinical observations. Areas covered: We provide a review of the mechanisms underlying the regulation of Keap1-Nrf2 at different stages, including genetic mutations, epigenetic modifications, translational/post-translational alterations, and protein-protein interactions. Read More

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http://dx.doi.org/10.1080/14728222.2019.1559824DOI Listing
March 2019
4 Reads

The potential of BRAF-associated non-coding RNA as a therapeutic target in melanoma.

Expert Opin Ther Targets 2019 Jan 9;23(1):53-68. Epub 2018 Dec 9.

a IRCCS , Regina Elena National Cancer Institute , Rome , Italy.

Introduction: The advent of targeted therapies and immune checkpoints inhibitors has enhanced the treatment of metastatic melanomas. Despite striking improvements of patients' survival, drug resistance continues to limit the efficacy of such treatments. Genetic and nongenetic/adaptive mechanisms of resistance could be involved; in the latter mechanism, noncoding RNAs (ncRNAs) are emerging as key players. Read More

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http://dx.doi.org/10.1080/14728222.2019.1554057DOI Listing
January 2019
3 Reads

The COX-2/prostanoid signaling cascades in seizure disorders.

Expert Opin Ther Targets 2019 Jan 2;23(1):1-13. Epub 2018 Dec 2.

a Department of Pharmacology , Emory University School of Medicine , Atlanta , GA , USA.

Introduction:A robust neuroinflammatory response is a prevalent feature of multiple neurological disorders, including epilepsy and acute status epilepticus. One component of this neuroinflammatory reaction is the induction of cyclooxygenase-2 (COX-2), synthesis of several prostaglandins and endocannabinoid metabolites, and subsequent activation of prostaglandin and related receptors. Neuroinflammation mediated by COX-2 and its downstream effectors has received considerable attention as a potential target class to ameliorate the deleterious consequences of neurological injury. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1554056DOI Listing
January 2019
14 Reads

New therapeutics based on emerging concepts in pulmonary fibrosis.

Expert Opin Ther Targets 2019 Jan 28;23(1):69-81. Epub 2018 Nov 28.

a Department of Pediatrics , University of Cincinnati, College of Medicine , Cincinnati , OH , USA.

Introduction: Fibrosis is an irreversible pathological endpoint in many chronic diseases, including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal condition characterized by (myo)fibroblast proliferation and transformation in the lung, expansion of the extracellular matrix, and extensive remodeling of the lung parenchyma. Recent evidence indicates that IPF prevalence and mortality rates are growing in the United States and elsewhere. Read More

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http://dx.doi.org/10.1080/14728222.2019.1552262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294998PMC
January 2019
24 Reads

Impaired brain plasticity as a potential therapeutic target for treatment and prevention of dementia.

Authors:
Tarek K Rajji

Expert Opin Ther Targets 2019 Jan 30;23(1):21-28. Epub 2018 Nov 30.

a Centre for Addiction and Mental Health and Department of Psychiatry , University of Toronto , Toronto , ON , Canada.

Introduction: In 2017, it was estimated that close to 50 million people were living with dementia worldwide and this number is expected to double every 20 years. No effective treatment exists yet probably because by the time Alzheimer's dementia (AD) has developed it is too late to intervene. Areas covered: Mild cognitive impairment (MCI) is a clinical state that typically precedes AD. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1550074DOI Listing
January 2019
11 Reads

Long noncoding RNA (lncRNA): a target in neuropathic pain.

Expert Opin Ther Targets 2019 Jan 2;23(1):15-20. Epub 2018 Dec 2.

a Department of Anesthesiology , New Jersey Medical School, Rutgers, The State University of New Jersey , Newark , NJ , USA.

Introduction: Current treatments for neuropathic pain are limited in part due to the incomplete understanding of its underlying mechanisms. Recent evidence reveals the dysregulated expression of long non-coding RNAs (lncRNAs) in the damaged nerve, dorsal root ganglion (DRG), and spinal cord dorsal horn following peripheral nerve injury. However, the role of the majority of lncRNAs in neuropathic pain genesis is still elusive. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1550075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294120PMC
January 2019
2 Reads

Targeting MTHFR for the treatment of migraines.

Expert Opin Ther Targets 2019 Jan 28;23(1):29-37. Epub 2018 Nov 28.

a Headache Center, Department of Neuroscience "Rita Levi Montalcini" , University of Torino , Torino , Italy.

Introduction: Migraine is a common neurovascular disorder classified by the World Health Organization as one of the most debilitating diseases. Migraine is a complex disease and is a consequence of an interaction between genetic, epigenetic and environmental factors. The MTHFR gene is one of the few replicated genetic risk factors for migraine and encodes an enzyme that is crucial for the folate and the methionine cycles. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
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http://dx.doi.org/10.1080/14728222.2019.1549544DOI Listing
January 2019
33 Reads

Indoleamine 2,3-dioxygenase as a novel therapeutic target for Huntington's disease.

Expert Opin Ther Targets 2019 Jan 22;23(1):39-51. Epub 2018 Nov 22.

a Department of Neurology, Albert Szent-Györgyi Clinical Center, Faculty of Medicine , University of Szeged , Szeged , Hungary.

Introduction: Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder. Despite the severe motor, psychiatric and cognitive symptoms and the great socioeconomic burden caused by the disease, available treatment is mainly symptomatic. The kynurenine pathway (KP) is the main metabolic route of tryptophan degradation, in the course of which several neuroactive compounds are generated. Read More

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http://dx.doi.org/10.1080/14728222.2019.1549231DOI Listing
January 2019
15 Reads

Oxidative/nitrosative stress, autophagy and apoptosis as therapeutic targets of melatonin in idiopathic pulmonary fibrosis.

Expert Opin Ther Targets 2018 12 16;22(12):1049-1061. Epub 2018 Nov 16.

a Razi Drug Research Center , Iran University of Medical Sciences , Tehran , Iran.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease associated with disruption of alveolar epithelial cell layer and expansion of fibroblasts/myofibroblasts. Excessive levels of oxidative/nitrosative stress, induction of apoptosis, and insufficient autophagy may be involved in IPF pathogenesis; hence, the targeting of these pathways may ameliorate IPF. Areas covered: We describe the ameliorative effect of melatonin on IPF. Read More

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http://dx.doi.org/10.1080/14728222.2018.1541318DOI Listing
December 2018
16 Reads
5.140 Impact Factor

The therapeutic potential of RNA regulation in neurological disorders.

Expert Opin Ther Targets 2018 12 31;22(12):1017-1028. Epub 2018 Oct 31.

a Neurogenetics Group , Center for Molecular Neurology, VIB , Antwerp , Belgium.

Introduction: Gene regulation is the term used to describe the mechanisms by which a cell increases or decreases the amount of a gene product (RNA or protein). In complex organs such as the brain, gene regulation is of the utmost importance; aberrations in the regulation of specific genes can lead to neurological disorders. Understanding these mechanisms can create new strategies for targeting these disorders and progress is being made. Read More

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http://dx.doi.org/10.1080/14728222.2018.1542429DOI Listing
December 2018
16 Reads

Targeting SOX2 in anticancer therapy.

Expert Opin Ther Targets 2018 12 26;22(12):983-991. Epub 2018 Oct 26.

a Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology , University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Mannheim , Germany.

Introduction: SOX2 is a transcription factor that is important in the development and maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer progression because it promotes the migration, invasion, and proliferation of cancer cells. SOX2 is also expressed in cancer stem cells and appears to be involved in the resistance toward anticancer therapies. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1
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http://dx.doi.org/10.1080/14728222.2018.1538359DOI Listing
December 2018
7 Reads

Long non-coding RNA CCAT2 as a therapeutic target in colorectal cancer.

Expert Opin Ther Targets 2018 12 30;22(12):973-976. Epub 2018 Oct 30.

a Division of Oncology, Department of Internal Medicine , Medical University of Graz , Graz , Austria.

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http://dx.doi.org/10.1080/14728222.2018.1541453DOI Listing
December 2018
14 Reads

HDAC6 as a potential therapeutic target for peripheral nerve disorders.

Expert Opin Ther Targets 2018 12;22(12):993-1007

a Department of Neurosciences , KU Leuven - University of Leuven, Experimental Neurology and Leuven Brain Institute (LBI) , Leuven , Belgium.

Introduction: Peripheral neuropathies are a heterogeneous group of diseases that are characterized by a progressive, ascending loss of nerve function arising from the peripheral regions of the limbs. The phenotypic overlap between different types of hereditary and acquired peripheral neuropathies indicates that similar pathophysiological processes are at play. Many downstream pathways in peripheral neurons, such as axonal transport, protein degradation, and interactions with Schwann cells, organelle damage, channelopathies, and neuroinflammatory signaling, have been proposed and each affects peripheral nerves in a negative way. Read More

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http://dx.doi.org/10.1080/14728222.2018.1541235DOI Listing
December 2018
4 Reads

Programmed cell death in human pathogenic fungi - a possible therapeutic target.

Expert Opin Ther Targets 2018 12 30;22(12):1039-1048. Epub 2018 Oct 30.

a Department of Biotechnology and Microbiology , University of Debrecen , Debrecen , Hungary.

Introduction: Diseases caused by pathogenic fungi are increasing because of antibiotic overuse, the rise of immunosuppressive therapies, and climate change. The limited variety of antimycotics and the rapid adaptation of pathogenic fungi to antifungal agents serve to exacerbate this issue. Unfortunately, about 1. Read More

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https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1
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http://dx.doi.org/10.1080/14728222.2018.1541087DOI Listing
December 2018
19 Reads