128,286 results match your criteria Expert opinion on emerging drugs[Journal]


Photodynamic therapy in infected venous and mixed leg ulcers: a pilot experience.

J Wound Care 2018 Dec;27(12):816-821

Consultant, Angiology Department, MD Barbantini Clinic, Lucca, Italy.

Objective:: To assess the tolerability and efficacy of photodynamic therapy (PDT) with RLP068, a novel phthalocyanine-derived photosensitiser, in controlling the bacterial load in different leg ulcers, due to vascular pathophysiology.

Method:: An observational study of patients with infected leg ulcers of different pathophysiology, admitted to the hospital for a skin grafting procedure, were included. All patients underwent two sessions of PDT at time zero and after 72 hours. Read More

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December 2018
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New insights into the pathophysiology of IgG4-related disease and markers of disease activity.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

a Division of Rheumatology, Department of Internal Medicine , Kanazawa University Graduate School of Medicine , Kanazawa , Japan.

Introduction: Recently, IgG4-related disease (IgG4-RD) has become a well-recognized clinical entity, although its causes are still not well understood. The pathophysiology of IgG4-RD has been reported from a variety of aspects. Areas covered: In this review, we outline a number of recent advances in our understanding of the pathogenesis of IgG4-RD, divided according to acquired immunology and innate immunology and other topics. Read More

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December 2018

Behcet's Disease in Iran; Analysis of 7641 Cases.

Mod Rheumatol 2018 Dec 17:1-21. Epub 2018 Dec 17.

a Behcet's Disease Unit, Rheumatology Research Center , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.

Objective: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare to 35 large/small reports from other countries.

Methods: Patients from all over Iran, when suspected, were sent to the BD Unit. The diagnosis was done by expert opinion. Read More

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December 2018
1 Read

The efficacy and safety of fluticasone salmeterol compared to fluticasone in children younger than four years of age.

Pediatr Allergy Immunol 2018 Dec 17. Epub 2018 Dec 17.

Clinical Operations Department, GlaxoSmithKline K.K, Tokyo, Japan.

Background: Fluticasone propionate 50 μg/salmeterol xinafoate 25 μg (FP/SAL) is widely used in adults and children with asthma but there is sparse information on its use in very young children.

Methods: This was a randomised, double-blind, multi-centre, controlled trial conducted in children aged 8 months to 4 years. During a 2-week run in period they all received FP twice daily. Read More

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December 2018

Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review.

JAMA Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.

Importance: Measurement of delirium severity has been recognized as highly important for tracking prognosis, monitoring response to treatment, and estimating burden of care for patients both during and after hospitalization. Rather than simply rating delirium as present or absent, the ability to quantify its severity would enable development and monitoring of more effective treatment approaches for the condition.

Objectives: To present a comprehensive review of delirium severity instruments, conduct a methodologic quality rating of the original validation study of the most commonly used instruments, and select a group of top-rated instruments. Read More

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December 2018

Proteomic analysis and antivenomics study of Western India Naja naja venom: Correlation between venom composition and clinical manifestations of cobra bite in this region.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology , Tezpur University , Tezpur 784028 , Assam , India.

Background: Snakebite is a severe problem in the tropical countries including Indian subcontinent. Premier cases of cobra bites are being reported from western India (WI).

Research Design And Methods: The proteome of WI N. Read More

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December 2018

Three-way interaction model with switching mechanism as an effective strategy for tracing functionally-related genes.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Department of Basic Sciences, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran .

Introduction: Identification of functionally-related genes is an important step in understanding biological systems. The most popular strategy to infer functional dependence is to study pairwise correlations between gene expression levels. However, certain functionally-related genes may have a low expression correlationdue to their nonlinear interactions. Read More

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December 2018

Targeting Hedgehog pathway in pediatric acute myeloid leukemia: challenges and opportunities.

Expert Opin Ther Targets 2018 Dec 17. Epub 2018 Dec 17.

a Department of Pediatrics, "Lalla Seràgnoli", Hematology-Oncology Unit , University of Bologna , Italy .

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December 2018
5 Reads

Cancer biomarker discovery and translation: proteomics and beyond.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD 21287.

Introduction: Cancer is often diagnosed at late stages when the chance of cure is relatively low and although research initiatives in oncology discover many potential cancer biomarkers, few transition to clinical applications. This review addresses the current landscape of cancer biomarker discovery and translation with a focus on proteomics and beyond. Areas covered: The review examines proteomic and genomic techniques for cancer biomarker detection and outlines advantages and challenges of integrating multiple omics approaches to achieve optimal sensitivity and address tumor heterogeneity. Read More

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December 2018

CD73 as a potential opportunity for cancer immunotherapy.

Expert Opin Ther Targets 2018 Dec 17. Epub 2018 Dec 17.

i Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran .

Introduction: Cancer cells apply various mechanisms to induce and enhance immune escape. The complex network of immune-response modulating factors in the tumor microenvironment is a reason for the difficulties encountered when attempting to treat many cancers. Adenosine is a potent immune-modulating factor that can be generated through the degradation of ATP by cooperative action of NTPDase1 (CD39) and ecto-5'-nucleotidase (CD73) molecules. Read More

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December 2018

Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung.

Expert Opin Ther Targets 2018 Dec 17. Epub 2018 Dec 17.

a Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Introduction: Kelch-like ECH associated protein 1/Nuclear factor erythroid 2-like factor 2 (Keap1-Nrf2) signaling plays a pivotal role in response to oxidative stress in lung cancer. Mutations in KEAP1/NFE2L2 genes always cause persistent Nrf2 activation in lung cancer cells that confers therapeutic resistance and aggressive tumorigenic activity, dictating either poor prognosis or short duration of response to chemotherapy in clinical observations. These findings suggest that modulation of Keap1-Nrf2 signaling presents to be a promising therapeutic target in adenocarcinomas of lung. Read More

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December 2018

Is the National Institute for Health and Care Excellence (NICE) in England more "innovation-friendly" than the Federal Joint Committee (G-BA) in Germany?

Expert Rev Pharmacoecon Outcomes Res 2018 Dec 17. Epub 2018 Dec 17.

a Division of Health Economics , German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) , Heidelberg , Germany.

Objectives: Our study explores whether, and how, different methodological choices are associated with different health technology assessment (HTA) outcomes. We focus on the Federal Joint Committee (Gemeinsamer Bundesausschuss, G-BA) in Germany and the National Institute for Health and Care Excellence (NICE) in England. Both agencies may be considered as exemplars for the application of the principles of evidence-based medicine and the logic of cost-effectiveness, respectively. Read More

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December 2018

Bevacizumab in refractory higher-grade and atypical meningioma: the current state of affairs.

Expert Opin Biol Ther 2018 Dec 17:1-6. Epub 2018 Dec 17.

e Department of Radiology and Imaging , State University of Medicine and Pharmacy "Nicolae Testemitanu" , Chisinau , Moldova.

Introduction: Historically, systemic agents had shown limited efficacy in meningioma, at the expense of significant pharmacologic and/or financial toxicity. As meningiomas are highly vascularized, they might derive benefit from antiangiogenic therapy. Areas covered: This review summarizes the literature regarding bevacizumab pharmacology, safety and efficacy in patients with refractory meningioma. Read More

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December 2018

Measuring disease activity and response to treatment in rheumatoid arthritis.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

b Department of Musculoskeletal Biology , Institute of Ageing and Chronic Disease, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital , Liverpool.

Introduction: Effective treatment of rheumatoid arthritis (RA) requires suppression of the underlying inflammation. Measurement of such inflammation, the disease activity, is mandatory to target treatment and maximize outcomes. However, this is not as straightforward as it may seem. Read More

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December 2018
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'If We Are to Believe the Psychologists …': Medicine, Psychoanalysis and Breastfeeding in Britain, 1900-55.

Authors:
Katharina Rowold

Med Hist 2019 Jan;63(1):61-81

In 1942, the British Minister of Health commissioned a report from the newly established Advisory Committee on Mothers and Young Children into 'What can be done to intensify the effort to secure more breast feeding of infants?'. To make their case, the members of the sub-committee put in charge of the report sought expert testimony on the benefits of breastfeeding. They consulted medical officers of health, maternity and child-welfare officers, health visitors, midwives, obstetricians, paediatricians and a physician in private practice. Read More

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January 2019

The Role of the Diabetes Educator in Diabetes Formulary and Medical Device Decisions.

Authors:

Diabetes Educ 2018 Dec 17:145721718820942. Epub 2018 Dec 17.

It is the position of the American Association of Diabetes Educators that diabetes educators should be included as expert consultants for formulary decisions regarding diabetes medications and medical devices. Read More

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December 2018

Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350.

Expert Opin Ther Pat 2018 Dec 17:1-6. Epub 2018 Dec 17.

a Istituto di Biostrutture e Bioimmagini-CNR , Naples , Italy.

Introduction: Based on the initial studies of J. Folkman in 1970s, which led to the proposal of the antiangiogenic therapy, many drugs targeting VEGF or its receptors have been developed with some of them approved for cancer treatment. However, these molecules so far have shown only a limited effect on survival benefits in patients. Read More

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December 2018

Improving the rates of Aspergillus detection: an update on current diagnostic strategies.

Expert Rev Anti Infect Ther 2018 Dec 17:1-12. Epub 2018 Dec 17.

d Division of Infectious Diseases, Department of Medicine , University of California-San Diego , San Diego , CA , USA.

Introduction: The spectrum of disease caused by Aspergillus spp. is dependent on the immune system of the host, and ranges from invasive aspergillosis (IA) to chronic pulmonary aspergillosis (CPA). Early and reliable diagnosis of Aspergillus disease is important to decrease associated morbidity and mortality. Read More

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December 2018

BRAF kinase inhibitors for treatment of melanoma: developments from early-stage animal studies to Phase II clinical trials.

Expert Opin Investig Drugs 2018 Dec 16:1-6. Epub 2018 Dec 16.

a Department of Dermatology , Tohoku University Graduate School of Medicine , Aoba-ku, Sendai , Japan.

Introduction: Approximately, 30.4-66.0% of cutaneous melanomas possess a mutation in the BRAF gene that activates downstream signaling through the mitogen-activated protein (MAP) kinase pathway; this provides an attractive target for the treatment of advanced melanoma. Read More

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December 2018

Cardiometabolic risks in PCOS: a review of the current state of knowledge.

Expert Rev Endocrinol Metab 2018 Dec 4:1-11. Epub 2018 Dec 4.

a Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% women of reproductive age. It is associated with a range of metabolic, reproductive, and psychological features. Current evidence indicates a role of PCOS in the development of metabolic and increased cardiovascular risk factors (CVRF) with implications for compromised cardiovascular endpoint disease, which may have a considerable impact on health and health care costs. Read More

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December 2018

Quality assessment of Ki67 staining using cell line proliferation index and stain intensity features.

Cytometry A 2018 Dec 17. Epub 2018 Dec 17.

Department of Health Science and Technology, Aalborg University, Fredrik Bajersvej 7D2, 9220, Aalborg, Denmark.

Breast cancer is the most frequent cancer among women worldwide. Ki67 can be used as an immunohistochemical pseudo marker for cell proliferation to determine how aggressive the cancer is and thereby the treatment of the patient. No standard Ki67 staining protocol exists, resulting in inter-laboratory stain variability. Read More

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December 2018

and unmet family planning need among Sub-Saharan African adolescents: the role of sexual and reproductive health stigma.

Qual Res Med Healthc 2018 May;2(1):55-64

University of Michigan, Women's Hospital, Ann Arbor, USA.

Adolescent pregnancy contributes to high maternal mortality rates in Sub-Saharan Africa. We explored stigma surrounding adolescent sexual and reproductive health (SRH) and its impact on young Ghanaian women's family planning (FP) outcomes. We conducted in-depth, semi-structured interviews with 63 women ages 15-24 recruited from health facilities and schools in Accra and Kumasi, Ghana. Read More

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Assessment of Detoxification Efficacy of Irradiation on Zearalenone Mycotoxin in Various Fruit Juices by Response Surface Methodology and Elucidation of Its Toxicity.

Front Microbiol 2018 30;9:2937. Epub 2018 Nov 30.

Toxicology and Immunology Division, DRDO-BU-Centre for Life Sciences, Bharathiar University, Coimbatore, India.

Fruits are vital portion of healthy diet owed to rich source of vitamins, minerals, and dietary fibers, which are highly favorable in keeping individual fit. Unfortunately, these days, one-third of fruits were infested with fungi and their toxic metabolites called mycotoxins, which is most annoying and pose significant health risk. Therefore, there is a need to suggest appropriate mitigation strategies to overcome the mycotoxins contamination in fruits. Read More

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November 2018

Why Does Advice Discounting Occur? The Combined Roles of Confidence and Trust.

Front Psychol 2018 28;9:2381. Epub 2018 Nov 28.

School of Psychology, Shandong Normal University, Jinan, China.

Judges tend to discount the opinions of others even though advice is often helpful in improving their accuracy. The present research proposes that this phenomenon of advice discounting results from the judges' confidence in their initial decision and little trust in advice. Furthermore, the degree of advice discounting may be predicted by the combined roles of confidence and trust. Read More

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November 2018

Watching or Listening: How Visual and Verbal Information Contribute to Learning a Complex Dance Phrase.

Front Psychol 2018 30;9:2371. Epub 2018 Nov 30.

Neurocognition and Action Research Group & Center of Excellence Cognitive Interaction Technology, Bielefeld University, Bielefeld, Germany.

While learning from observation is generally regarded as major learning mode for motor actions, evidence from dance practice suggests that learning dance movement through verbal instruction might provide a promising way to support dancers' individual interpretation of and identification with the movement material. In this multidisciplinary project, we conducted a study on the learning of dance movement through two modalities, observation of a human model in a video clip and listening to the audio-recording of a verbal movement instruction. Eighteen second year dance students learned two dance phrases, one from observation and one from verbal instruction, and were video-recorded performing the learned material. Read More

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November 2018

Expert and Novice Performers Respond Differently to Attentional Focus Cues for Speed Jump Roping.

Front Psychol 2018 29;9:2370. Epub 2018 Nov 29.

Motor Behavior Laboratory, Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, Knoxville, TN, United States.

Directing attention to an external focus has been shown to facilitate motor performance. For expert performers, however, results have been mixed. Additionally, little is currently known about how focus cues affect the performance of complex continuous whole-body coordination tasks involving object manipulation such as jump roping. Read More

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November 2018

[Readiness factors to improve the work environment using an employee participatory approach: Development and validation of readiness state checklist.]

Sangyo Eiseigaku Zasshi 2018 Dec 15. Epub 2018 Dec 15.

Objectives: The employee participatory approach is an effective method for improving work environments. However, there are some challenges in executing this method in each workplace because of such factors as a lack of employee interest or motivation to commit to the activity. Research was conducted to clarify readiness factors to improve the workplace environment using an employee participatory approach. Read More

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December 2018

One-shot domain adaptation in multiple sclerosis lesion segmentation using convolutional neural networks.

Neuroimage Clin 2018 Dec 10:101638. Epub 2018 Dec 10.

Research institute of Computer Vision and Robotics, University of Girona, Spain.

In recent years, several convolutional neural network (CNN) methods have been proposed for the automated white matter lesion segmentation of multiple sclerosis (MS) patient images, due to their superior performance compared with those of other state-of-the-art methods. However, the accuracies of CNN methods tend to decrease significantly when evaluated on different image domains compared with those used for training, which demonstrates the lack of adaptability of CNNs to unseen imaging data. In this study, we analyzed the effect of intensity domain adaptation on our recently proposed CNN-based MS lesion segmentation method. Read More

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December 2018

Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder.

Eur Neuropsychopharmacol 2018 Dec 13. Epub 2018 Dec 13.

Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands; Arq Psychotrauma Expert Center, Diemen, The Netherlands.

Post-traumatic stress disorder (PTSD) is characterized by difficulty down-regulating emotional responses towards trauma-reminders. The neuropeptide oxytocin may enhance treatment response in PTSD, by dampening excessive fear and improving fear regulation. However, oxytocin effects on (neural correlates of) cognitive emotion regulation abilities have never been investigated in PTSD patients. Read More

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December 2018

Cross-cultural adaptation and psychometric evaluation of the early childhood oral health impact scale (ECOHIS) in chilean population.

Health Qual Life Outcomes 2018 Dec 16;16(1):232. Epub 2018 Dec 16.

Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The Early Childhood Oral Health Impact Scale (ECOHIS) measures the impact of dental diseases on Oral Health-Related Quality of Life both in children and their families. The aim of this study was to develop a Chilean Spanish version of the ECOHIS that is conceptually equivalent to the original and to assess its acceptability, reliability and validity in the preschool population of Chile.

Methods: The Chilean version of the ECOHIS was obtained through a process including forward and back-translation, expert panel, and cognitive debriefing interviews. Read More

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December 2018

Cerebellar tonsil ectopia measurement in type I Chiari malformation patients show poor inter-operator reliability.

Fluids Barriers CNS 2018 Dec 17;15(1):33. Epub 2018 Dec 17.

Department of Biological Engineering, University of Idaho, 875 Perimeter Drive MS 0904, Moscow, ID, 83844-0904, USA.

Background: Type 1 Chiari malformation (CM-I) has been historically defined by cerebellar tonsillar position (TP) greater than 3-5 mm below the foramen magnum (FM). Often, the radiographic findings are highly variable, which may influence the clinical course and patient outcome. In this study, we evaluate the inter-operator reliability (reproducibility) of MRI-based measurement of TP in CM-I patients and healthy controls. Read More

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December 2018

Physiologically based pharmacokinetic (PBPK) modeling and simulation in neonatal drug development: how clinicians can contribute.

Expert Opin Drug Metab Toxicol 2018 Dec 17:1-10. Epub 2018 Dec 17.

b Department of Development and Regeneration , KU Leuven , Leuven , Belgium.

Introduction: Legal initiatives to stimulate neonatal drug development should be accompanied by development of valid research tools. Physiologically based (PB)-pharmacokinetic (PK) modeling and simulation are established tools, accepted by regulatory authorities. Consequently, PBPK holds promise to be a strong research tool to support neonatal drug development. Read More

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December 2018

Structural Validity of the World Assumption Scale.

J Trauma Stress 2018 Dec;31(6):816-825

Department of Philosophy, Vrije Universiteit, Amsterdam, the Netherlands.

The World Assumption Scale (WAS) is a frequently used measure in trauma research. The 32 items of the WAS are intended to represent eight assumptions about the benevolence of the world, the meaningfulness of events, and the worthiness of the self. Debate about the validity of the WAS is ongoing, particularly in terms of its empirical factor structure; some studies have confirmed a model of eight correlated factors whereas several other studies have not. Read More

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December 2018

A Multi-Model Framework to Estimate Perfusion Parameters Using Contrast-Enhanced Ultrasound Imaging.

Med Phys 2018 Dec 16. Epub 2018 Dec 16.

Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Purpose: Contrast-enhanced ultrasound imaging (CEUS) has expanded the diagnostic potential of ultrasound by enabling real-time imaging and quantification of tissue perfusion. Several perfusion models and curve fitting methods have been developed to quantify the temporal behavior of tracer signal and standardize perfusion quantification. While the least-squares approach has traditionally been applied for curve-fitting, it can be inadequate for noisy and complex data. Read More

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December 2018

Red flags for appropriate referral to the gastroenterologist & rheumatologist of patients with inflammatory bowel disease & spondyloarthritis.

Clin Exp Immunol 2018 Dec 15. Epub 2018 Dec 15.

IBD Unit, Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy.

Collaboration between gastroenterologists and rheumatologists is recommended for correct management of patients with associated spondyloarthritis (SpA) and inflammatory bowel disease (IBD). We aimed to establish the appropriateness of several red flags for a prompt specialist referral. A systematic review of the literature was performed using the GRADE method to describe the prevalence of coexisting IBD-SpA and the diagnostic accuracy of red flags proposed by a steering committee. Read More

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December 2018

Histological dating of subdural hematoma in infants.

Int J Legal Med 2018 Dec 15. Epub 2018 Dec 15.

Forensic Department, APHM, La Timone, 264 rue St Pierre, 13385, Marseille, Cedex 05, France.

Background: After infant deaths due to non-accidental head injury (NAHI) with subdural hematoma (SDH), the magistrates ask experts to date the traumatic event. To do so, the expert only has tools based on adult series of NAHI. We aimed to develop an SDH dating system applicable to infants aged under 3 years. Read More

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December 2018

Italian Translation and Cross-Cultural Adaptation of a Back Pain Screening Questionnaire (Start Back Screening Tool).

Ann Ig 2019 Jan-Feb;31(1):69-75

Research Department, Accademia Italiana di Medicina Osteopatica (AIMO), Saronno, Italy.

Background: Low back pain is a heterogeneous condition, from which most patients recover after a few months. However, a considerable proportion of patients develop chronic pain despite different types of treatment. Primary care evidence-based guidelines for non-specific back pain highlight the importance of identifying indicators of poor prognosis in order for treatment to be appropriately targeted. Read More

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December 2018

Endoscopic Submucosal Dissection in Patients with Ulcerative Colitis.

Digestion 2018 Dec 14;99(1):27-32. Epub 2018 Dec 14.

Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo,

Patients with ulcerative colitis have an increased risk of developing colorectal cancer. This risk has been estimated to reach about 7% at 20 years of disease, 7-14% at 25 years, and as high as 30% after 35 years. The guidelines for the management of inflammatory bowel disease recommend endoscopic resection of circumscribed dysplasia and ongoing colonoscopic surveillance as a reasonable strategy in patients with ulcerative colitis. Read More

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December 2018

Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

S.R. Johnson MD PhD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Mount Sinai Hospital; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. D. Khanna MD MS, Division of Rheumatology, Department of Medicine, University of Michigan, USA. R. Cervera MD PhD FRCP, Hospital Clínic, Barcelona, Spain. N. Costedoat-Chalumeau MD PhD AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, Paris, France ; Université Paris Descartes-Sorbonne Paris Cité, Paris, France ; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. D.D. Gladman MD FRCPC, Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. B.H. Hahn MD, University of California Los Angeles, Los Angeles, USA. F. Hiepe MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. J. Sánchez-Guerrero MD MSc, Division of Rheumatology, Department of Medicine Mount Sinai Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada; and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. E. Massarotti MD, Brigham and Women's Hospital, Boston MA; Harvard Medical School, Boston, USA. D.T. Boumpas MD FACP FACR, National and Kapodestrian University of Athens, and Biomedical Research Foundation of the Athens Academy, Athens, Greece. K.H Costenbader MD MPH, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, USA. D. Daikh MD, University of California, San Francisco, USA. D. Jayne MD FRCP FRCPE FMedSci, Department of Medicine, University of Cambridge, United Kingdom. T. Dörner MD, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Charitéplatz 1, 10117 Berlin, Germany. D.L. Kamen MD MSCR, Medical University of South Carolina, Charleston, USA. M. Mosca MD PhD, University of Pisa, Italy. R. Ramsey-Goldman MD DrPH, Northwestern University Feinberg School of Medicine, Chicago, USA. J.S. Smolen MD, Medical University of Vienna, Austria. D. Wofsy MD, University of California, San Francisco, USA. M. Aringer MD, University Medical Center and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. Address correspondence to Sindhu Johnson MD PhD, Division of Rheumatology, Ground Floor, East Wing, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada, M5T 2S8. Phone 1-416-603-6417 Fax.1-416-603- 4348. Email:

Objective: Given the complexity and heterogeneity of systemic lupus erythematosus (SLE), high performing classification criteria are critical to advancing research and clinical care. A collaborative effort by EULAR and ACR was undertaken to generate candidate criteria, and then to reduce them to a smaller set. The objective of the current study was to select a set of criteria that maximizes the likelihood of accurate classification of SLE, particularly early disease. Read More

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December 2018

Five financial incentives to revive the Gulf of Mexico dead zone and Mississippi basin soils.

J Environ Manage 2018 Dec 13;233:30-38. Epub 2018 Dec 13.

The Nature Conservancy, Arlington, VA, USA.

A central challenge in the Mississippi River Basin is how to continue to support profitable agricultural production, provide water supply, flood control, transportation, and other benefits, while reducing the current burden of environmental degradation. Several practices have been shown to reduce nutrient runoff and water pollution, and improve soil fertility, while often yielding profits for farmers. Yet many of these beneficial practices remain underutilized. Read More

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December 2018
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Automated and manual hippocampal segmentation techniques: Comparison of results, reproducibility and clinical applicability.

Neuroimage Clin 2018 Oct 14:101574. Epub 2018 Oct 14.

Department of Neurology, Indiana University, Indianapolis, IN, USA; Department of Radiological Sciences, Indiana University, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. Electronic address:

Background: Imaging techniques used to measure hippocampal atrophy are key to understanding the clinical progression of Alzheimer's disease (AD). Various semi-automated hippocampal segmentation techniques are available and require human expert input to learn how to accurately segment new data. Our goal was to compare 1) the performance of our automated hippocampal segmentation technique relative to manual segmentations, and 2) the performance of our automated technique when provided with a training set from two different raters. Read More

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October 2018

Carl August Krauspe (1895-1983)-Founder and honorary member of the "European Society of Pathology" and "politically reliable" National Socialist.

Pathol Res Pract 2018 Dec 5. Epub 2018 Dec 5.

Institute for History, Theory and Ethics of Medicine, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Germany. Electronic address:

The name of the Hamburg pathologist Carl August Krauspe (1895-1983) is closely linked to the history of the "European Society of Pathology" (ESP) and the "German Pathological Society" (DGP): He was one of the founding fathers of the ESP, became its vice president, and was appointed an honorary member in 1983. From 1953-1962 he also served as secretary of the DGP and editor of the association's proceedings. In 1962/63 he finally held the chairmanship of the DGP. Read More

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December 2018

Discharge materials provided to patients with kidney stones in the emergency department may be a source of misinformation.

Can J Urol 2018 Dec;25(6):9585-9590

University of Vermont Medical Center, Burlington, Vermont, USA.

Introduction: Renal colic is commonly seen in the emergency department (ED), where the focus is on diagnosis and symptom control. Educational materials are sometimes provided upon discharge, however, no standard content has been established. We characterized the educational materials given to patients reporting to EDs in different regions across the U. Read More

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December 2018

Educational needs for new graduate nurses in Korea.

Nurse Educ Pract 2018 Dec 5;34:167-172. Epub 2018 Dec 5.

College of Nursing, Ewha Womans University, Hellen hall, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, South Korea. Electronic address:

New nursing graduates often experience difficulty adjusting to clinical work environments, despite completing well-structured education programs. This study explored the educational needs of recent nursing graduates from the perspectives of new nurses and their clinical educators in Korea. Four focus-group interviews with 7 nurse educators and 8 new nurses were conducted. Read More

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December 2018
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Machine learning for predicting psychotic relapse at 2 years in schizophrenia in the national FACE-SZ cohort.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Fondation FondaMental, Créteil, France; Faculté de Médecine, Université d'Auvergne, CMP B, CHU, EA 7280, Clermont-Ferrand Cedex 69 63003, France.

Background: Predicting psychotic relapse is one of the major challenges in the daily care of schizophrenia.

Objectives: To determine the predictors of psychotic relapse and follow-up withdrawal in a non-selected national sample of stabilized community-dwelling SZ subjects with a machine learning approach.

Methods: Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical and cognitive assessment, including recording of current treatment. Read More

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December 2018
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Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI.

Eur J Nucl Med Mol Imaging 2018 Dec 14. Epub 2018 Dec 14.

SyMPTOm PET/MRI Platform, Nuclear Medicine Department, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, 51 avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.

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December 2018

Development of a tool to assess beliefs about mythical causes of cancer: the Cancer Awareness Measure Mythical Causes Scale.

BMJ Open 2018 Dec 14;8(12):e022825. Epub 2018 Dec 14.

Research Department of Behavioural Science and Health, University College London, London, UK.

Objectives: We aimed to develop a reliable and valid measure to assess public beliefs in mythical causes of cancer: the Cancer Awareness Measure-MYthical Causes Scale (CAM-MYCS).

Design And Setting: Cancer myth items were generated from a literature review, social media and interviews (n=16). The CAM-MYCS was prepared by reducing items using (a) an online sample (n=527) with exploratory factor analysis and (b) cancer experts with Delhpi methodology (n=13). Read More

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December 2018

study: protocol for a stepped-wedge cluster randomised trial to compare access to care for a mobile app versus a workstation-based store-and-forward teledermatology process.

BMJ Open 2018 Dec 14;8(12):e022218. Epub 2018 Dec 14.

US Department of Veterans Affairs, Center for Access Policy, Evaluation and Research, Boston, Massachusetts, USA.

Introduction: Teledermatology has emerged as an important strategy to enhance access to high-quality skin care. is a provider-facing, web-based mobile app designed to integrate into the existing teledermatology workflow in the US Veterans Health Administration (VHA). In this study, we will conduct a systematic evaluation of on access outcomes in VHA facilities using a pragmatic trial guided by clinical and operational leaders. Read More

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December 2018
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Data Integrity-Based Methodology and Checklist for Identifying Implementation Risks of Physiological Sensing in Mobile Health Projects: Quantitative and Qualitative Analysis.

JMIR Mhealth Uhealth 2018 Dec 14;6(12):e11896. Epub 2018 Dec 14.

Mobile Health Systems Lab, Institute of Robotics and Intelligent Systems, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Background: Mobile health (mHealth) technologies have the potential to bring health care closer to people with otherwise limited access to adequate health care. However, physiological monitoring using mobile medical sensors is not yet widely used as adding biomedical sensors to mHealth projects inherently introduces new challenges. Thus far, no methodology exists to systematically evaluate these implementation challenges and identify the related risks. Read More

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December 2018

Oesophagectomy: The expanding role of minimally invasive surgery in oesophageal cancer.

Best Pract Res Clin Gastroenterol 2018 Oct - Dec;36-37:75-80. Epub 2018 Nov 21.

Department of Upper GI Surgery and General Surgery, Norfolk and Norwich University Hospital, Colney Lane, NR4 7UY, Norwich, United Kingdom. Electronic address:

Historically, open oesophagectomy was the gold standard for oesophageal cancer surgery. This was associated with a relatively higher morbidity. In the last two decades, we have seen significant improvements in short and long term outcomes due to centralisation of oesophagectomy, multidisciplinary approach, enhanced recovery after surgery programmes, neoadjuvant treatments and advances in minimally invasive oesophagectomy (MIO) techniques. Read More

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November 2018