128,155 results match your criteria Expert Reviews in Molecular Medicine [Journal]
Psychiatr Prax 2018 Dec 12. Epub 2018 Dec 12.
Fachbereich Sozialwesen, Hochschule Niederrhein, University of Applied Sciences, Mönchengladbach.
Objective: This study explores the conditions for the stakeholders' cooperation in an integrative care model for people with psychosocial problems.
Methods: Expert interviews on various community mental health care providers were led and content analyzed.
Results: Joint objectives and conceptually comparable financing models were found to be essential for cooperation across mental health and social integration services. Read More
Endoscopy 2018 Dec 12. Epub 2018 Dec 12.
Division of Gastroenterology, HSK Hospital, Wiesbaden, Germany.
Background: Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification of visual characteristics to identify colitis-associated neoplasia using multimodal advanced endoscopic imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification).
Methods: The study was conducted in three phases: 1) development - an expert panel defined endoscopic signs and predictors of dysplasia in IBD and, using multivariable logistic regression created the FACILE classification; 2) validation - using 60 IBD lesions from an image library, two assessments of diagnostic accuracy for neoplasia were performed and interobserver agreement between experts using FACILE was determined; 3) reproducibility - the reproducibility of the FACILE classification was tested in gastroenterologists, trainees, and junior doctors after completion of a training module. Read More
Am J Clin Nutr 2018 Dec;108(6):1357-1368
School of Nutrition Sciences, University of Ottawa, Ottawa, Ontario, Canada.
The Government of Canada and the Society of Obstetricians and Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 µg folic acid (FA) for the primary prevention of neural tube defects among low-risk women from before conception and throughout lactation. Prenatal supplements marketed and prescribed in Canada typically exceed the recommended dose, usually providing ≥1000 µg FA/d. This high daily dose, coupled with staple-food FA fortification, has resulted in the observation of very high blood folate concentrations among reproductive-aged women consuming FA-containing supplements. Read More
Horm Res Paediatr 2018 Dec 12:1-9. Epub 2018 Dec 12.
Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
Background: Hair glucocorticoids (GCs) offer a retrospective view on chronic GC exposure. We assessed whether maternal pre- and postnatal stress was associated with neonatal and maternal hair GCs postpartum (pp).
Methods: On the first day pp 172 mother-infant pairs donated hair, of whom 67 had consulted a centre of expertise for psychiatric disorders during pregnancy. Read More
Expert Opin Emerg Drugs 2018 Dec 12:1-9. Epub 2018 Dec 12.
a Division of Pediatric Nephrology , University Childrens Hospital, Universitatsklinikum Bonn , Bonn , Germany.
Introduction: Currently, three types of primary hyperoxaluria (PH I-III) are known, all based on different gene-mutations affecting the glyoxylate metabolism in the liver. Disease hallmark is an increased endogenous oxalate production and thus massively elevated urinary excretion of oxalate and other type-specific metabolites. Hyperoxaluria induces the formation of calcium-oxalate kidney stones and/or nephrocalcinosis. Read More
PLoS One 2018 12;13(12):e0208535. Epub 2018 Dec 12.
Department of Zoology, Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise, Tartu, Estonia.
Finding standard cost-effective methods for monitoring biodiversity is challenging due to trade-offs between survey costs (including expertise), specificity, and range of applicability. These trade-offs cause a lack of comparability among datasets collected by ecologists and conservationists, which is most regrettable in taxonomically demanding work on megadiverse inconspicuous taxon groups. We have developed a site-scale survey method for diverse sessile land organisms, which can be analyzed over multiple scales and linked with ecological insights and management. Read More
Rev Gastroenterol Peru 2018 Jul-Sep;38(3):261-264
Universidad Cooperativa de Colombia. Pasto, Nariño, Colombia.
Peritonitis is one of the main complications of abdominal emergencies. Laparoscopy serves both for the diagnostic and therapeutic management of the acute abdomen; in expert hands the morbimortality of this method is minimal.
Objective: The objective is to verify the efficacy of laparoscopy in patients with secondary peritonitis performing a single surgery without the need for reinterventions, ensuring the least damage of the abdominal wall, avoiding laparotomy. Read More
Med Sci Sports Exerc 2018 Dec 11. Epub 2018 Dec 11.
Carnegie School of Sport, Leeds Beckett University, Leeds, United Kingdom.
Purpose: Pre-participation health screening is recommended to detect individuals susceptible to serious adverse cardiovascular complications during exercise. Although expert opinion and best available scientific evidence have informed recent modifications, there remains limited experimental data to support or refute current practice. We therefore aimed to quantify the impact of change to the ACSM pre-participation health screening guidelines on risk classification and referral for medical clearance in a large cohort of undergraduate university students. Read More
Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.
Division of Pulmonary, Critical Care and Sleep Medicine, MetroHealth Medical Center, Cleveland, Ohio.
Background: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications.
Methods: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network. Read More
Am J Surg Pathol 2018 Dec 11. Epub 2018 Dec 11.
INSERM1052, CNRS 5286, Lyon-Sud Charles Mérieux Lyon-1 Faculty, Claude Bernard University.
Gray-zone lymphoma (GZL) with features intermediate between classic Hodgkin lymphoma (cHL) and large B-cell lymphoma (LBCL) was introduced as a provisional entity into the World Health Organization classification in 2008. However, as diagnostic criteria are imprecise, reliable identification of GZL cases remains challenging. Here, we describe the histopathologic features of 139 GZL cases from a retrospective Lymphoma Study Association (LYSA) study with the goal to improve classification accuracy. Read More
Expert Opin Drug Saf 2018 Dec 12:1-12. Epub 2018 Dec 12.
a Aging Research Center, Department of Neurobiology , Care Sciences and Society, Karolinska Institutet & Stockholm University , Stockholm , Sweden.
Introduction: Polypharmacy, the use of multiple medications by one individual, is increasingly common among older adults. Caring for the growing number of older people with complex drug regimens and multimorbidity presents an important challenge in the coming years. Areas covered: This article reviews the international trends in the prevalence of polypharmacy, summarizes the results from previous reviews on polypharmacy and negative health outcomes, and updates a previous review on the clinical consequences of polypharmacy by focusing on studies published after 2013. Read More
Sports Biomech 2018 Dec 12:1-9. Epub 2018 Dec 12.
b Game Insight Group , Tennis Australia , Melbourne , Australia.
The non-invasive measurement of movement through sensor technologies is common in elite sport, yet only recently become possible in tennis. This study validated two commercial tennis racquet sensors compared to gold standards in VICON and expert notational analysis. One national-level male tennis player hit 24 shots (9 forehands and 9 backhands, hit with heavy topspin, flat and slice; 6 serves) using a Babolat Play racket with a Zepp sensor. Read More
Adv Physiol Educ 2019 Mar;43(1):15-27
Molecular, Cellular, and Developmental Biology, University of Colorado-Boulder , Boulder, Colorado.
We describe the development of a new, freely available, online, programmatic-level assessment tool, Measuring Achievement and Progress in Science in Physiology, or Phys-MAPS ( http://cperl.lassp.cornell. Read More
Acta Biomed 2018 Dec 7;89(7-S):50-59. Epub 2018 Dec 7.
Background And Aim: The nursing diagnosis can based on two different approaches: the standard diagnosis, searching for regularities that can fall within pre-existing categories identified by the nurse, as the expert of the disease; the narrative diagnosis, based on personal meaning attributed to the illness, of which only the patient is the expert. The aim of this work is to underline the usefulness of integration between standard diagnosis and narrative diagnosis, through the Integrated Personalized Nursing Diagnosis (IPND).
Methods: A 31 years old man, suffering from leukaemia, is welcomed at an Italian Oncological Day Hospital, by a nurse trained in the IPND approach. Read More
Expert Opin Investig Drugs 2018 Dec 12. Epub 2018 Dec 12.
d Early Phase Therapeutics Program , University of Arizona Cancer Center , Tucson AZ , USA .
Introduction: Prognosis remains dismal for pancreatic ductal adenocarcinoma (PDAC). Genomics and proteomics has depicted heterogeneity in PDAC. Collectively, this information could be useful in improving diagnosis, prognosis, modalities of therapy, treatment responses, deciphering drug resistance and new drug development. Read More
Eur J Gen Pract 2018 Dec 12:1-7. Epub 2018 Dec 12.
g Department of Family Medicine and Primary Health Care , Ghent University , Ghent , Belgium.
Background: In 2017, the European Commission (EC) identified as a policy priority the performance assessment of primary care systems, which relates to a country's primary care structure, services delivery and outcomes. The EC requested its Expert Panel on Effective Ways of Investing in Health (Expert Panel) to provide an opinion on ways for improving performance assessment of primary care.
Objectives: To provide an overview of domains and dimensions to be taken into consideration in assessing primary care and specific indicators to be collected and analysed to improve understanding of primary care performance. Read More
Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.
Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Univ. Paris Descartes, PRES Sorbonne Paris Cité, Hôpital Cochin, Assistance Publique -Hôpitaux de Paris, INSERM UMR-S 1124, UFR Biomédicale des Saints Pères, Paris, France.
Background And Aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.
Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. Read More
Med Klin Intensivmed Notfmed 2018 Dec 11. Epub 2018 Dec 11.
, Sigebandweg 25, 04279, Leipzig, Deutschland.
GMS J Med Educ 2018 15;35(4):Doc48. Epub 2018 Nov 15.
University of Heidelberg, Department of General, Visceral, and Transplantation Surgery, Heidelberg, Germany.
Chest tube insertion is a standard intervention for management of various injuries of the thorax. Efficient clinical training of this and similar bed-side procedures is equally demanded and improvable. Here, we propose a nouveau means of assessment and feedback using an Objective Structured Assessment of Technical Skills (OSATS) tool. Read More
Front Surg 2018 27;5:71. Epub 2018 Nov 27.
Department of Surgery and Center for Minimally Invasive Surgery, Academic Teaching Hospital of Charité Medical School, Vivantes Hospital, Berlin, Germany.
A meta-analysis that compared the onlay vs. sublay technique in open incisional hernia repair identified better outcomes for the sublay operation. Nonetheless, an Expert Consensus Guided by Systematic Review found the onlay mesh location useful in certain settings. Read More
Ital J Food Saf 2018 Sep 26;7(3):7394. Epub 2018 Sep 26.
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
The paper describes the terminology of risk assessment in the view of food safety: different aspects of social involvement are defined and discussed; the terms Document, Expert, Risk manager, Lay Knowledge, Participant, Participation, Citizens' involvement, Community of interest, Consultation, Trust and Social trust are presented. Also, the terms Adverse effects, Human Illness Source Attribution, Food hygiene, Emerging disease, Safety, Food security and Food safety are discussed. Read More
Nat Sci Sleep 2018 26;10:397-408. Epub 2018 Nov 26.
Neurology Department, Massachusetts General Hospital, Boston, MA 02114, USA.
Background: Although in-lab polysomnography (PSG) remains the gold standard for objective sleep monitoring, the use of at-home sensor systems has gained popularity in recent years. Two categories of monitoring, autonomic and limb movement physiology, are increasingly recognized as critical for sleep disorder phenotyping, yet at-home options remain limited outside of research protocols. The purpose of this study was to validate the BiostampRC sensor system for respiration, electrocardiography (ECG), and leg electromyography (EMG) against gold standard PSG recordings. Read More
Int Med Case Rep J 2018 20;11:339-344. Epub 2018 Nov 20.
Department of Ophthalmology, Federal Health Sciences University of Porto Alegre, Porto Alegre, Brazil,
Objective: To describe, in a multimodal way, a new RHO gene mutation with lysine-for-asparagine substitution in autosomal dominant retinitis pigmentosa.
Methods: Case report. Retrospective data analysis. Read More
BMC Med Educ 2018 Dec 11;18(1):302. Epub 2018 Dec 11.
Department of Medicine, The Ottawa Hospital, University of Ottawa and the Ottawa Hospital Research Institute, 501 Smyth Road CPCR L2135, Box 209, Ontario, Ottawa, K1H 8L6, Canada.
Background: Physicians in training must achieve a high degree of proficiency in performing physical examinations and must strive to become experts in the field. Concerns are emerging about physicians' abilities to perform these basic skills, essential for clinical decision making. Learning at the bedside has the potential to support skill acquisition through deliberate practice. Read More
Appl Netw Sci 2016 5;1(1). Epub 2016 Sep 5.
1Privacy and Data Security, Department of Computer Science, TU Dresden, Nöthnitzer Straße 46, Dresden, 01187 Germany.
Graphs are used to model a wide range of systems from different disciplines including social network analysis, biology, and big data processing. When analyzing these constantly changing dynamic graphs at a high frequency, performance is the main concern. Depending on the graph size and structure, update frequency, and read accesses of the analysis, the use of different data structures can yield great performance variations. Read More
Zentralbl Chir 2018 Dec 11;143(6):609-616. Epub 2018 Dec 11.
Unfallchirurgie, Bundeswehrkrankenhaus Berlin, Deutschland.
Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the healing process. Read More
Epilepsy Behav 2018 Dec 8;90:148-153. Epub 2018 Dec 8.
Icahn School of Medicine at Mount Sinai Health Systems, 10 Union Square East, Suite 5G, New York, NY 10003, USA. Electronic address:
Background: The complex clinical presentation and progression of Lennox-Gastaut syndrome (LGS) can complicate the accurate diagnosis of this severe, lifelong, childhood-onset epilepsy, often resulting in suboptimal treatment. The Refractory Epilepsy Screening Tool for LGS (REST-LGS) was developed to improve the identification of patients with LGS.
Methods: Using the Modified Delphi Consensus, a group of experts developed and tested the REST-LGS Case Report Form (CRF) comprising 8 criteria (4 major, 4 minor) considered potentially indicative of LGS. Read More
J Forensic Leg Med 2018 Dec 5;61:97-101. Epub 2018 Dec 5.
Past Director of the Complex Unit of Auxology, Faculty of Medicine and Surgery, Università degli Studi di Torino, Turin, Italy. Electronic address:
Background: Maturation is the irreversible biological process leading to adult form or function. The degree of maturation can be derived from the examination of maturity indicators, i.e. Read More
Food Chem Toxicol 2018 Dec 8. Epub 2018 Dec 8.
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.
Department of Chemical & Petroleum Engineering, Sharif University of Technology, Tehran, Iran.
In this study, lyophilized advanced platelet rich fibrin (A-PRF) was used in combination with collagen-chitosan membrane for the first time to combine advantages of both collagen and A-PRF membranes. Response surface methodology (RSM) was used to design the experimental condition and to correlate the effects of parameters, including chitosan/collagen (chit/col) weight ratio and A-PRF concentration on Young's modulus, mesenchymal stem cell (MSCs) viability and degradation rate of the membranes. Results showed that Young's modulus of the membranes was intensified by increasing chit/col weight ratio and decreasing A-PRF concentration from 3 to 8 MPa. Read More
Expert Opin Biol Ther 2018 Dec 11. Epub 2018 Dec 11.
d Marlene and Stewart Greenebaum Comprehensive Cancer Center , University of Maryland School of Medicine , Baltimore , Maryland.
Introduction: Head and neck squamous cell carcinomas (HNSCC) previously had limited treatment options once patients had progressed on systemic chemotherapy. With recent advances, immunotherapy now plays an important role in the treatment of advanced disease with improved outcomes as compared to cytotoxic chemotherapy. Areas covered: This article reviews the effects of the immune system and how it influences the development and response to HNSCC therapy. Read More
Med Phys 2018 Dec 8. Epub 2018 Dec 8.
Department of Electrical and Computer Engineering, the University of Iowa.
Purpose: To investigate the use and efficiency of 3-D deep learning, fully convolutional networks (DFCN) for simultaneous tumor co-segmentation on dual-modality non-small cell lung cancer (NSCLC) PET-CT images.
Methods: We used DFCN co-segmentation for NSCLC tumors in PET-CT images, considering both the CT and PET information. The proposed DFCN-based co-segmentation method consists of two coupled 3D-UNets with an encoder-decoder architecture, which can communicate with the other in order to share complementary information between PET and CT. Read More
Adv Mater 2018 Dec 9:e1805936. Epub 2018 Dec 9.
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing, 210009, China.
A new synergistic treatment that combines photothermal therapy (PTT) and inflammation-mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the photothermal tumor ablation is accompanied by an inflammatory effect and upregulation of inflammatory factors at the tumor site, which may accelerate tumor regeneration. Moreover, PTT-induced inflammation can also recruit neutrophils (NEs) to the tumor site. Read More
Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.
Department of Radiology, National Cancer Center/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Background: The study was conducted to evaluate the performance of a state-of-the-art commercial deep learning-based computer-aided diagnosis (DL-CAD) system for detecting and characterizing pulmonary nodules.
Methods: Pulmonary nodules in 346 healthy subjects (male: female = 221:125, mean age 51 years) from a lung cancer screening program conducted from March to November 2017 were screened using a DL-CAD system and double reading independently, and their performance in nodule detection and characterization were evaluated. An expert panel combined the results of the DL-CAD system and double reading as the reference standard. Read More
Prenat Diagn 2018 Dec 10. Epub 2018 Dec 10.
Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada.
Objective: Fetal myelomeningocele (fMMC) surgery improves infant outcomes when compared with postnatal surgery. Surgical selection criteria and the option of pregnancy termination, however, limit the number of cases that are eligible for prenatal surgery. We aimed to quantify what proportion of cases could ultimately benefit from fetal therapy. Read More
J Appl Res Intellect Disabil 2018 Dec 10. Epub 2018 Dec 10.
Intellectual Disability Medicine, Department of General Practice, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Background: Resistance training has beneficial effects on fitness levels, cardiovascular disease risk, risk of sarcopenia and on performing activities of daily living. The focus of this study is to design a total body resistance exercise set for adults with intellectual disabilities (RESID) with minimal equipment required and to test its feasibility.
Method: The RESID was selected in an expert meeting, and its feasibility was determined in a cross-sectional pilot study. Read More
Headache 2018 Dec 10. Epub 2018 Dec 10.
Objective: To provide healthcare professionals with updated guidance in the use of novel preventive and acute treatments for migraine in adults.
Background: The principles of preventive and acute pharmacotherapy for patients with migraine have been outlined previously, but the emergence of new technologies and treatments, as well as new formulations of previously established treatments, has created a need for an updated guidance on the preventive and acute treatment of migraine.
Methods: This statement is based on a review of existing guidelines and principles for preventive and acute treatment of migraine, as well as the results of recent clinical trials of drugs and devices for these indications. Read More
Forensic Sci Med Pathol 2018 Dec 10. Epub 2018 Dec 10.
Unit of Legal Medicine, Department of Physiology and Pharmacology, University of Cantabria, Av Cardenal Herrera Oria s/n, 39011, Santander, Spain.
Humans constantly lose epithelial cells, and these biological traces are frequently studied in the context of criminal investigations. The objective of this work was to examine the genetic profile in samples of forensic interest (nail and skin epithelial cells) of bone marrow transplant patients and discuss its forensic and clinical implications. The genetic profile of nail, epidermal cells and blood samples of patients receiving HSCT was analyzed by the amplification and sequencing of 38 insertion/deletion polymorphisms and 15 short tandem repeat polymorphisms. Read More
J Cancer Surviv 2018 Dec 8. Epub 2018 Dec 8.
School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.
Background: Self-management may help cancer survivors to better deal with challenges to their physical, functional, social and psychological well-being presented by cancer and its treatment. Nonetheless, little is known about how people integrate cancer self-management practices into their daily lives. The aim of this study was to describe and characterise the processes through which head and neck cancer (HNC) survivors attempt to integrate self-management into their daily lives following primary treatment. Read More
Surg Today 2018 Dec 7. Epub 2018 Dec 7.
Department of Cardiovascular Surgery, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-8072, Japan.
Purpose: This review summarizes the recent progress made in understanding the skill acquisition process of achieving expert status in various fields that require fine motor skills. We discuss the attempts to apply this progress to develop competent surgeons.
Methods: We reviewed the existing literature, using the keywords "surgical training", "skill acquisition", and "simulator-based training", using Medline, as well as recent books and chapters related to these issues. Read More
Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.
Physics Department, University of Pavia, Pavia, Italy.
The success of any research programme is dependent on a continuing influx of new expertise, and continuing education to ensure the newest technologies and methods are exploited. In the past decade, a strategic approach has been used to build up the research expertise in the area of radiation protection and risk estimation. The High Level Expert Group (HLEG, www. Read More
J Hosp Med 2018 Nov 28. Epub 2018 Nov 28.
Assistant Vice President of Health Sciences for Interprofessional Education and Collaborative Care, Virginia Commonwealth University Health System, Richmond, Virginia, USA.
Background: Hospitals are complex adaptive systems within which multiple components such as patients, practitioners, facilities, and technology interact. A careful approach to optimization of this complex system is needed because any change can result in unexpected deleterious effects. One such approach is discrete event simulation, in which what-if scenarios allow researchers to predict the impact of a proposed change on the system. Read More
Pain Rep 2018 Sep-Oct;3(5):e656. Epub 2018 Sep 10.
Health Technology Assessment Unit, Center of Clinical Research, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Background: Chronic pain is a prevalent and distressing condition caused by an unceasing pain lasting more than 3 months or a pain that persists beyond the normal healing time. There is evidence of inadequate management partly explained by the unawareness regarding the magnitude of the problem.
Objectives: To estimate the annual expected costs and consequences of chronic pain caused by musculoskeletal diseases from the health system perspective in Chile. Read More