501 results match your criteria Expert Reviews in Molecular Medicine [Journal]


Arbovirus lifecycle in mosquito: acquisition, propagation and transmission.

Expert Rev Mol Med 2019 03 13;21:e1. Epub 2019 Mar 13.

Tsinghua-Peking Center for Life Sciences,School of Medicine,Tsinghua University,Beijing, 100084,China.

Mosquitoes are haematophagous vectors for hundreds of pathogenic viruses that are aetiological agents of human diseases. In nature, mosquito-borne viruses maintain a lifecycle between mosquitoes and vertebrate animals. Viruses are acquired by a naive mosquito from an infected host by blood meals and then propagate extensively in the mosquito's tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2018.6DOI Listing

Craniofacial, orofacial and dental disorders: the role of the RAS/ERK pathway.

Expert Rev Mol Med 2019 03 13;21:e2. Epub 2019 Mar 13.

School of Medicine,University of Crete,Crete,Greece.

Deviations from the precisely coordinated programme of human head development can lead to craniofacial and orofacial malformations often including a variety of dental abnormalities too. Although the aetiology is still unknown in many cases, during the last decades different intracellular signalling pathways have been genetically linked to specific disorders. Among these pathways, the RAS/extracellular signal-regulated kinase (ERK) signalling cascade is the focus of this review since it encompasses a large group of genes that when mutated cause some of the most common and severe developmental anomalies in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2019.2DOI Listing

Structure, regulation and related diseases of the actin-binding protein gelsolin.

Expert Rev Mol Med 2019 01 30;20:e7. Epub 2019 Jan 30.

Department of Functional and Clinical Anatomy,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Germany.

Gelsolin (GSN), one of the most abundant actin-binding proteins, is involved in cell motility, shape and metabolism. As a member of the GSN superfamily, GSN is a highly structured protein in eukaryotic cells that can be regulated by calcium concentration, intracellular pH, temperature and phosphatidylinositol-4,5-bisphosphate. GSN plays an important role in cellular mechanisms as well as in different cellular interactions. Read More

View Article

Download full-text PDF

Source
https://www.cambridge.org/core/product/identifier/S146239941
Publisher Site
http://dx.doi.org/10.1017/erm.2018.7DOI Listing
January 2019
7 Reads

Potential clinical applications of circulating cell-free DNA in ovarian cancer patients.

Expert Rev Mol Med 2018 12 18;20:e6. Epub 2018 Dec 18.

Cancer Genetics Group,IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto),Porto,Portugal.

Circulating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called 'liquid biopsy', as a non-invasive cancer biomarker has recently received a lot of attention. Read More

View Article

Download full-text PDF

Source
https://www.cambridge.org/core/product/identifier/S146239941
Publisher Site
http://dx.doi.org/10.1017/erm.2018.5DOI Listing
December 2018
15 Reads

Animal-type melanoma: dog or wolf? A review of the literature and a case report.

Expert Rev Mol Med 2018 09 12;20:e5. Epub 2018 Sep 12.

Department of Biomedical Sciences and Human Oncology,University of Bari 'Aldo Moro',P.zza G. Cesare,11 - 70124 Bari,Italy.

The human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more common melanocytic lesions, as well as for its peculiar biological behaviour. On the other hand, the contribution of scientific literature to this issue is fragmented and limited to the description of very few cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2018.4DOI Listing
September 2018
4 Reads
5.152 Impact Factor

What has traditional Chinese medicine delivered for modern medicine?

Expert Rev Mol Med 2018 05 11;20:e4. Epub 2018 May 11.

Artemisinin Research Center, China Academy of Chinese Medical Sciences,Beijing 100700,China.

The field of Traditional Chinese Medicine (TCM) represents a vast and largely untapped resource for modern medicine. Exemplified by the success of the antimalarial artemisinin, the recent years have seen a rapid increase in the understanding and application of TCM-derived herbs and formulations for evidence-based therapy. In this review, we summarise and discuss the developmental history, clinical background and molecular basis of an action for several representative TCM-derived medicines, including artemisinin, arsenic trioxide, berberine and Salvia miltiorrhiza or Danshen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2018.3DOI Listing
May 2018
20 Reads
5.150 Impact Factor

The genetics and molecular biology of fever-associated seizures or epilepsy.

Expert Rev Mol Med 2018 04 17;20:e3. Epub 2018 Apr 17.

Department of Neurology,the Third Xiangya Hospital, Central South University,Changsha,China.

Fever-associated seizures or epilepsy (FASE) is primarily characterised by the occurrence of a seizure or epilepsy usually accompanied by a fever. It is common in infants and children, and generally includes febrile seizures (FS), febrile seizures plus (FS+), Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFSP). The aetiology of FASE is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2018.2DOI Listing
April 2018
4 Reads

Oestrogen, progesterone and stem cells: the discordant trio in endometriosis?

Expert Rev Mol Med 2018 03 8;20:e2. Epub 2018 Mar 8.

Cancer Research Program-4,Rajiv Gandhi Centre for Biotechnology,Thiruvananthapuram 695014,Kerala,India.

Oestrogen-progesterone signalling is highly versatile and critical for the maintenance of healthy endometrium in humans. The genomic and nongenomic signalling cascades initiated by these hormones in differentiated cells of endometrium have been the primary focus of research since 1920s. However, last decade of research has shown a significant role of stem cells in the maintenance of a healthy endometrium and the modulatory effects of hormones on these cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.13DOI Listing
March 2018
4 Reads

Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases.

Expert Rev Mol Med 2018 01 18;20:e1. Epub 2018 Jan 18.

Institute of Molecular Biomedicine,Faculty of Medicine,Comenius University,Bratislava,Slovakia.

Cell-free DNA (cfDNA) is present in various body fluids and originates mostly from blood cells. In specific conditions, circulating cfDNA might be derived from tumours, donor organs after transplantation or from the foetus during pregnancy. The analysis of cfDNA is mainly used for genetic analyses of the source tissue -tumour, foetus or for the early detection of graft rejection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.12DOI Listing
January 2018
9 Reads

Clinical and therapeutic potential of protein kinase PKR in cancer and metabolism.

Expert Rev Mol Med 2017 07 20;19:e9. Epub 2017 Jul 20.

Oncology Department, Oncology Unit,Virgen de las Nieves University Hospital,Granada,Spain.

The protein kinase R (PKR, also called EIF2AK2) is an interferon-inducible double-stranded RNA protein kinase with multiple effects on cells that plays an active part in the cellular response to numerous types of stress. PKR has been extensively studied and documented for its relevance as an antiviral agent and a cell growth regulator. Recently, the role of PKR related to metabolism, inflammatory processes, cancer and neurodegenerative diseases has gained interest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.11DOI Listing
July 2017
3 Reads

FMR1 CGG repeat expansion mutation detection and linked haplotype analysis for reliable and accurate preimplantation genetic diagnosis of fragile X syndrome.

Expert Rev Mol Med 2017 07 19;19:e10. Epub 2017 Jul 19.

Department of Pediatrics,Yong Loo Lin School of Medicine, National University of Singapore,Singapore 119074,Singapore.

Fragile X mental retardation 1 (FMR1) full-mutation expansion causes fragile X syndrome. Trans-generational fragile X syndrome transmission can be avoided by preimplantation genetic diagnosis (PGD). We describe a robust PGD strategy that can be applied to virtually any couple at risk of transmitting fragile X syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733830PMC
July 2017
27 Reads

Bilateral Wilms tumour: a review of clinical and molecular features.

Expert Rev Mol Med 2017 07 18;19:e8. Epub 2017 Jul 18.

UCL Institute of Child Health,University College London,London,UK.

Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse, nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5-8% of cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687181PMC
July 2017
12 Reads

Insights into the mechanisms of copper dyshomeostasis in amyotrophic lateral sclerosis.

Expert Rev Mol Med 2017 06 9;19:e7. Epub 2017 Jun 9.

Neurosciences Area, Biodonostia Institute, Donostia Hospital,San Sebastian,Spain.

Amyotrophic lateral sclerosis (ALS) is a severe neuromuscular disease characterised by a progressive loss of motor neurons that usually results in paralysis and death within 2 to 5 years after disease onset. The pathophysiological mechanisms involved in ALS remain largely unknown and to date there is no effective treatment for this disease. Here, we review clinical and experimental evidence suggesting that dysregulation of copper homeostasis in the central nervous system is a crucial underlying event in motor neuron degeneration and ALS pathophysiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.9DOI Listing
June 2017
20 Reads

Intracellular delivery of biologic therapeutics by bacterial secretion systems.

Expert Rev Mol Med 2017 04 6;19:e6. Epub 2017 Apr 6.

Department of Life Sciences,Imperial College London,London SW7 2AZ,UK.

Biologics are a promising new class of drugs based on complex macromolecules such as proteins and nucleic acids. However, delivery of these macromolecules into the cytoplasm of target cells remains a significant challenge. Here we present one potential solution: bacterial nanomachines that have evolved over millions of years to efficiently deliver proteins and nucleic acids across cell membranes and between cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479498PMC
April 2017
3 Reads

Pandora's Box: mitochondrial defects in ischaemic heart disease and stroke.

Expert Rev Mol Med 2017 04 5;19:e5. Epub 2017 Apr 5.

Department of Nuclear Medicine,Odense University Hospital,Odense,Denmark.

Ischaemic heart disease and stroke are vascular events with serious health consequences worldwide. Recent genetic and epigenetic techniques have revealed many genetic determinants of these vascular events and simplified the approaches to research focused on ischaemic heart disease and stroke. The pathogenetic mechanisms of ischaemic heart disease and stroke are complex, with mitochondrial involvement (partially or entirely) recently gaining substantial support. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.5DOI Listing
April 2017
7 Reads

Helicobacter pylori as an oncogenic pathogen, revisited.

Expert Rev Mol Med 2017 03 21;19:e4. Epub 2017 Mar 21.

Department of Medicine,Gastroenterology and Hepatology Section,Baylor College of Medicine,Houston,Texas 77030,USA.

Gastric cancer is an inflammation-associated malignancy aetiologically related to infection with the bacterium, Helicobacter pylori, which is considered a necessary but insufficient cause. Unless treated, H. pylori causes life-long acute and chronic gastric inflammation resulting in progressive gastric mucosal damage that may result in gastric cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.4DOI Listing
March 2017
31 Reads

Epithelial, mesenchymal and hybrid epithelial/mesenchymal phenotypes and their clinical relevance in cancer metastasis.

Authors:
Minal Garg

Expert Rev Mol Med 2017 03 21;19:e3. Epub 2017 Mar 21.

Department of Biochemistry,University of Lucknow,Lucknow - 226007,UP,India.

Cancer metastasis occurs through local invasion of circulating tumour cells (CTCs), intravasation, transportation to distant sites, and their extravasation followed by colonisation at secondary sites. Epithelial-mesenchymal transition (EMT) is a normal developmental phenomenon, but its aberrant activation confers tumour cells with enhanced cell motility, metastatic properties, resistant to therapies and cancer stem cell (CSC) phenotype in epithelium-derived carcinoma. Experimental studies from various research papers have been reviewed to determine the factors, which interlink cancer stemness and cellular plasticity with EMT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.6DOI Listing
March 2017
2 Reads

FRZB and melusin, overexpressed in LGMD2A, regulate integrin β1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.

Expert Rev Mol Med 2017 03 16;19:e2. Epub 2017 Mar 16.

Neurosciences Area,Biodonostia Health Research Institute,San Sebastián,Spain.

Limb-girdle muscular dystrophy type 2A (LGMD2A) is characterised by muscle wasting and progressive degeneration of proximal muscles because of mutations in the CAPN3 gene. However, the underlying pathophysiological mechanisms of muscle degeneration are still not well understood. The objective of this study was to assess the relevance of genes with differential expression in the muscle of LGMD2A patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.3DOI Listing
March 2017
36 Reads

Molecular approaches for HPV genotyping and HPV-DNA physical status.

Expert Rev Mol Med 2017 02 6;19:e1. Epub 2017 Feb 6.

Department of Biochemistry & Biotechnology,Microbiology-Virology Laboratory,University of Thessaly,School of Health Sciences,Larissa,Greece.

Persistent infection with high-risk human papillomavirus (HPV) genotypes is the leading cause of cervical cancer development. To this end several studies have focused on designing molecular assays for HPV genotyping, which are considered as the gold standard for the early diagnosis of HPV infection. Moreover, the tendency of HPV DNA to be integrated into the host chromosome is a determining event for cervical oncogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2017.2DOI Listing
February 2017
3 Reads

Novel insight into triple-negative breast cancers, the emerging role of angiogenesis, and antiangiogenic therapy.

Expert Rev Mol Med 2016 11 7;18:e18. Epub 2016 Nov 7.

Research Centre for Functional Genomics,Biomedicine and Translational Medicine,Iuliu Hatieganu University of Medicine and Pharmacy,Cluj-Napoca,Romania.

Triple-negative breast cancer (TNBC) is a heterogeneous group of tumours characterised by lack of expression of oestrogen-, progesterone- and human epidermal growth factor receptors. TNBC, which represents approximately 15% of all mammary tumours, has a poor prognosis because of an aggressive behaviour and the lack of specific treatment. Accordingly, TNBC has become a major focus of research into breast cancer and is now classified into several molecular subtypes, each with a different prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.17DOI Listing
November 2016
23 Reads

Emerging therapies for acute intermittent porphyria.

Expert Rev Mol Med 2016 11 2;18:e17. Epub 2016 Nov 2.

Instituto de Investigación Sanitaria de Navarra (IdiSNA),Pamplona,Spain.

Acute intermittent porphyria (AIP) is an autosomal dominant metabolic disease caused by hepatic deficiency of hydroxymethylbilane synthase (HMBS), the third enzyme of the heme synthesis pathway. The dominant clinical feature is acute neurovisceral attack associated with high production of potentially neurotoxic porphyrin precursors due to increased hepatic heme consumption. Current Standard of Care is based on a down-regulation of hepatic heme synthesis using heme therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.18DOI Listing
November 2016
12 Reads

C-X-C motif chemokine 10 in non-alcoholic steatohepatitis: role as a pro-inflammatory factor and clinical implication.

Expert Rev Mol Med 2016 Sep 27;18:e16. Epub 2016 Sep 27.

Institute of Digestive Disease and the Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong,Shatin, Hong Kong,China.

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. Non-alcoholic steatohepatitis (NASH) is a more severe form of NAFLD and causes subsequent pathological changes including cirrhosis and hepatocellular carcinoma. Inflammation is the key pathological change in NASH and involves a series of cytokines and chemokines. Read More

View Article

Download full-text PDF

Source
http://www.journals.cambridge.org/abstract_S1462399416000168
Publisher Site
http://dx.doi.org/10.1017/erm.2016.16DOI Listing
September 2016
4 Reads

Application of multiplex immunoassay technology to investigations of ocular disease.

Expert Rev Mol Med 2016 08 31;18:e15. Epub 2016 Aug 31.

Raybiotech, Inc.,Norcross, GA,USA.

Eye-derived fluids, including tears, aqueous humour and vitreous humour often contain molecular signatures of ocular disease states. These signatures can be composed of cytokines, chemokines, growth factors, proteases and soluble receptors. However, the small quantities (<10 µl) of these fluids severely limit the detection of these proteins by traditional enzyme-linked immunosorbent assay or Western blot. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.15DOI Listing
August 2016
4 Reads

Molecular mechanism of hepatic steatosis: pathophysiological role of autophagy.

Authors:
Kewei Wang

Expert Rev Mol Med 2016 08 8;18:e14. Epub 2016 Aug 8.

Departments of Surgery,University of Illinois College of Medicine,One Illini Drive,Peoria,IL 61605,USA.

Unlabelled: Steatosis is an early characteristic in the pathogenesis of fatty liver disease (FLD). Mechanisms of hepatic steatosis are aetiology-dependent. Activation of autophagy in liver ameliorates hepatic steatosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.14DOI Listing
August 2016
9 Reads

Aβ-Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment.

Expert Rev Mol Med 2016 06 30;18:e13. Epub 2016 Jun 30.

Protein Folding and Stability Group,Departament de Bioquímica i Biologia Molecular,Universitat Autònoma de Barcelona,Facultat de Biociències,08193 Bellaterra,Barcelona,Spain.

Current therapies to treat Alzheimer's disease (AD) are focused on ameliorating symptoms instead of treating the underlying causes of AD. The accumulation of amyloid β (Aβ) oligomers, whether by an increase in production or by a decrease in clearance, has been described as the seed that initiates the pathological cascade in AD. Developing therapies to target these species is a vital step in improving AD treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.11DOI Listing
June 2016
4 Reads

The immunological landscape in necrotising enterocolitis.

Expert Rev Mol Med 2016 06 24;18:e12. Epub 2016 Jun 24.

Ritchie Centre,Hudson Institute of Medical Research,Melbourne,Australia.

Necrotising enterocolitis (NEC) is an uncommon, but devastating intestinal inflammatory disease that predominantly affects preterm infants. NEC is sometimes dubbed the spectre of neonatal intensive care units, as its onset is insidiously non-specific, and once the disease manifests, the damage inflicted on the baby's intestine is already disastrous. Subsequent sepsis and multi-organ failure entail a mortality of up to 65%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001507PMC
June 2016
11 Reads

Genome research in pre-dementia stages of Alzheimer's disease.

Expert Rev Mol Med 2016 05 30;18:e11. Epub 2016 May 30.

Memory Clinic of Fundació ACE,Institut Català de Neurociències Aplicades,Barcelona,Spain.

Genetic characterization of individuals at risk of Alzheimer's disease (AD), i.e. people having amyloid deposits in the brain without symptoms, people suffering from subjective cognitive decline (SCD) or mild cognitive impairment (MCI), has spurred the interests of researchers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.12DOI Listing
May 2016
5 Reads

Editorial.

Expert Rev Mol Med 2016 May 10;18:e10. Epub 2016 May 10.

Department of Medicine,University of Cambridge,UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.10DOI Listing
May 2016
8 Reads

Protein pathways working in human follicular fluid: the future for tailored IVF?

Expert Rev Mol Med 2016 May 6;18:e9. Epub 2016 May 6.

Department of Molecular and Developmental Medicine,University of Siena,Viale Bracci 14,53100 Siena,Italy.

The human follicular fluid (HFF) contains molecules and proteins that may affect follicle growth, oocyte maturation and competence acquiring. Despite the numerous studies, an integrated broad overview on biomolecular and patho/physiological processes that are proved or supposed to take place in HFF during folliculogenesis and oocyte development is still missing. In this review we report, for the first time, all the proteins unambiguously detected in HFF and, applying DAVID (Database for Annotation, Visualization and Integrated Discovery) and MetaCore bioinformatic resources, we shed new lights on their functional correlation, delineating protein patterns and pathways with reasonable potentialities for oocyte quality estimation in in vitro fertilisation (IVF) programs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.4DOI Listing
May 2016
6 Reads

The complex metabolism of trimethylamine in humans: endogenous and exogenous sources.

Expert Rev Mol Med 2016 Apr 29;18:e8. Epub 2016 Apr 29.

Molecular Medicine Group,International Centre for Genetic Engineering and Biotechnology,New Delhi,India.

Trimethylamine (TMA) is a tertiary amine with a characteristic fishy odour. It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during both healthy and diseased conditions in humans. Trimethylaminuria (TMAU) is a disease typified by its association with the characteristic fishy odour because of decreased TMA metabolism and excessive TMA excretion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.6DOI Listing
April 2016
11 Reads

Preclinical models of atherosclerosis. The future of Hybrid PET/MR technology for the early detection of vulnerable plaque.

Expert Rev Mol Med 2016 Apr 8;18:e6. Epub 2016 Apr 8.

Cardiology Department,University Francisco de Vitoria/Hospital Ramón y Cajal,Ctra. Colmenar Viejo,km 9,100,28034 Madrid,Spain.

Cardiovascular diseases are the leading cause of death in developed countries. The aetiology is currently multifactorial, thus making them very difficult to prevent. Preclinical models of atherothrombotic diseases, including vulnerable plaque-associated complications, are now providing significant insights into pathologies like atherosclerosis, and in combination with the most recent advances in new non-invasive imaging technologies, they have become essential tools to evaluate new therapeutic strategies, with which can forecast and prevent plaque rupture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.5DOI Listing
April 2016
23 Reads

Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.

Expert Rev Mol Med 2016 Apr 8;18:e7. Epub 2016 Apr 8.

Neuroscience Area,Biodonostia Research Institute,San Sebastian,Spain.

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a form of muscular dystrophy caused by mutations in calpain 3 (CAPN3). Several studies have implicated Ca2+ dysregulation as an underlying event in several muscular dystrophies, including LGMD2A. In this study we used mouse and human myotube cultures, and muscle biopsies in order to determine whether dysfunction of sarco/endoplasmatic Ca2+-ATPase (SERCA) is involved in the pathology of this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836212PMC
April 2016
11 Reads

Mechanisms of prion-induced neurodegeneration.

Expert Rev Mol Med 2016 Apr 8;18:e5. Epub 2016 Apr 8.

Scientific Affairs,Holland Laboratory,American Red Cross,Rockville, MD,USA.

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are fatal neurodegenerative disorders characterised by long incubation period, short clinical duration, and transmissibility to susceptible species. Neuronal loss, spongiform changes, gliosis and the accumulation in the brain of the misfolded version of a membrane-bound cellular prion protein (PrP(C)), termed PrP(TSE), are diagnostic markers of these diseases. Compelling evidence links protein misfolding and its accumulation with neurodegenerative changes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.8DOI Listing
April 2016
4 Reads

The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.

Expert Rev Mol Med 2016 Mar 21;18:e4. Epub 2016 Mar 21.

Department of Neurology,Chongqing Key Laboratory of Neurology,The First Affiliated Hospital of Chongqing Medical University,1 Youyi Road,Chongqing 400016,China.

miR-124, a brain-specific microRNA, was originally considered as a key regulator in neuronal differentiation and the development of the nervous system. Here we showed that miR-124 expression was suppressed in patients with epilepsy and rats after drug induced-seizures. Intrahippocampal administration of a miR-124 duplex led to alleviated seizure severity and prolonged onset latency in two rat models (pentylenetetrazole- and pilocarpine-induced seizures), while miR-124 inhibitor led to shortened onset latency in pilocarpine-induced seizure rat models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836211PMC
March 2016
35 Reads

The emerging role of GATA transcription factors in development and disease.

Expert Rev Mol Med 2016 Mar 8;18:e3. Epub 2016 Mar 8.

Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2016.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836206PMC
March 2016
10 Reads

Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis.

Expert Rev Mol Med 2016 Jan 19;18:e1. Epub 2016 Jan 19.

Department of Human Anatomy and Cell Science,College of Medicine,Faculty of Health Sciences,University of Manitoba,Winnipeg,Canada.

Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836210PMC
January 2016
17 Reads
5 Citations
5.152 Impact Factor

Targeting translation: eIF4E as an emerging anticancer drug target.

Expert Rev Mol Med 2016 Jan 18;18:e2. Epub 2016 Jan 18.

College of Life Sciences,Anhui Normal University,Key Laboratory of Biotic Environment and Ecological Safety in Anhui Province,Wuhu 241000,Anhui,China.

The translation initiation factor eIF4E mediates a rate-limiting process that drives selective translation of many oncongenic proteins such as cyclin D1, survivin and VEGF, thereby contributing to tumour growth, metastasis and therapy resistance. As an essential regulatory hub in cancer signalling network, many oncogenic signalling pathways appear to converge on eIF4E. Therefore, targeting eIF4E-mediated cap-dependent translation is considered a promising anticancer strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.20DOI Listing
January 2016
34 Reads
8 Citations
5.152 Impact Factor

Dental stem cells: a future asset of ocular cell therapy.

Expert Rev Mol Med 2015 Nov 10;17:e20. Epub 2015 Nov 10.

Tissue Engineering and Stem Cell Group,Singapore Eye Research Institute,Singapore.

Regenerative medicine using patient's own stem cells (SCs) to repair dysfunctional tissues is an attractive approach to complement surgical and pharmacological treatments for aging and degenerative disorders. Recently, dental SCs have drawn much attention owing to their accessibility, plasticity and applicability for regenerative use not only for dental, but also other body tissues. In ophthalmology, there has been increasing interest to differentiate dental pulp SC and periodontal ligament SC (PDLSC) towards ocular lineage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.16DOI Listing
November 2015
17 Reads
8 Citations
5.152 Impact Factor

Engineered T cell therapies.

Expert Rev Mol Med 2015 Nov 4;17:e19. Epub 2015 Nov 4.

Molecular Immunology Unit,Institute of Child Health (ICH),University College London (UCL),30 Guilford Street,London WC1N 1EH,UK.

Alongside advancements in gene therapy for inherited immune disorders, the need for effective alternative therapeutic options for other conditions has resulted in an expansion in the field of research for T cell gene therapy. T cells are easily obtained and can be induced to divide robustly ex vivo, a characteristic that allows them to be highly permissible to viral vector-mediated introduction of transgenes. Pioneering clinical trials targeting cancers and infectious diseases have provided safety and feasibility data and important information about persistence of engineered cells in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.14DOI Listing
November 2015
5 Reads

Advances in the molecular genetics of non-syndromic polydactyly.

Expert Rev Mol Med 2015 Oct 30;17:e18. Epub 2015 Oct 30.

Center for Experimental Medicine and Department of Neurology,the Third Xiangya Hospital,Central South University,Changsha 410013,China.

Polydactyly is one of the most common inherited limb abnormalities, characterised by supernumerary fingers or toes. It results from disturbances in the normal programme of the anterior-posterior axis of the developing limb, with diverse aetiology and variable inter- and intra-familial clinical features. Polydactyly can occur as an isolated disorder (non-syndromic polydactyly) or as a part of an anomaly syndrome (syndromic polydactyly). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.18DOI Listing
October 2015
22 Reads

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities.

Expert Rev Mol Med 2015 Oct 28;17:e17. Epub 2015 Oct 28.

The Kinghorn Cancer Centre,Cancer Division,Garvan Institute of Medical Research,384 Victoria St,Darlinghurst,Sydney,NSW 2010,Australia.

The Rho/ROCK pathway is involved in numerous pivotal cellular processes that have made it an area of intense study in cancer medicine, however, Rho-associated coiled-coil containing protein kinase (ROCK) inhibitors are yet to make an appearance in the clinical cancer setting. Their performance as an anti-cancer therapy has been varied in pre-clinical studies, however, they have been shown to be effective vasodilators in the treatment of hypertension and post-ischaemic stroke vasospasm. This review addresses the various roles the Rho/ROCK pathway plays in angiogenesis, tumour vascular tone and reciprocal feedback from the tumour microenvironment and explores the potential utility of ROCK inhibitors as effective vascular normalising agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836205PMC
October 2015
28 Reads

Heart valve tissue engineering: how far is the bedside from the bench?

Expert Rev Mol Med 2015 Sep 24;17:e16. Epub 2015 Sep 24.

Division of Pharmaceutical Biosciences,Faculty of Pharmacy,University of Helsinki,Viikinkaari 5 E,P.O. Box 56,00014 Helsinki,Finland.

Heart disease, including valve pathologies, is the leading cause of death worldwide. Despite the progress made thanks to improving transplantation techniques, a perfect valve substitute has not yet been developed: once a diseased valve is replaced with current technologies, the newly implanted valve still needs to be changed some time in the future. This situation is particularly dramatic in the case of children and young adults, because of the necessity of valve growth during the patient's life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.15DOI Listing
September 2015
8 Reads

Novel roles and therapeutic targets of Epstein-Barr virus-encoded latent membrane protein 1-induced oncogenesis in nasopharyngeal carcinoma.

Expert Rev Mol Med 2015 Aug 18;17:e15. Epub 2015 Aug 18.

Cancer Research Institute,Central South University,Changsha,Hunan 410078,China.

Epstein-Barr virus (EBV) was first discovered 50 years ago as an oncogenic gamma-1 herpesvirus and infects more than 90% of the worldwide adult population. Nasopharyngeal carcinoma (NPC) poses a serious health problem in southern China and is one of the most common cancers among the Chinese. There is now strong evidence supporting a role for EBV in the pathogenesis of NPC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.13DOI Listing
August 2015
37 Reads

Oestrogens as apoptosis regulators in mammalian testis: angels or devils?

Expert Rev Mol Med 2015 Jan 27;17:e2. Epub 2015 Jan 27.

CICS-UBI, Health Sciences Research Centre, University of Beira Interior,Av. Infante D. Henrique,6200-506 Covilhã,Portugal.

In the mammalian testis, spermatogenesis is a highly coordinated process of germ cell development, which ends with the release of 'mature' spermatozoa. The fine regulation of spermatogenesis is strictly dependent on sex steroid hormones, which orchestrate the cellular and molecular events underlying normal development of germ cells. Sex steroids actions also rely on the control of germ cell survival, and the programmed cell death by apoptosis has been indicated as a critical process in regulating the size and quality of the germ line. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2014.25DOI Listing
January 2015
3 Reads
2 Citations
5.152 Impact Factor

Insights into the molecular mechanisms of action of bioportides: a strategy to target protein-protein interactions.

Expert Rev Mol Med 2015 Jan 27;17:e1. Epub 2015 Jan 27.

Molecular Pharmacology Group,Research Institute in Healthcare Science, University of Wolverhampton,Wulfruna Street,Wolverhampton WV1 1LY,UK.

Cell-penetrating peptides (CPPs) are reliable vehicles for the target-selective intracellular delivery of therapeutic agents. The identification and application of numerous intrinsically bioactive CPPs, now designated as bioportides, is further endorsement of the tremendous clinical potential of CPP technologies. The refinement of proteomimetic bioportides, particularly sequences that mimic cationic α-helical domains involved in protein-protein interactions (PPIs), provides tremendous opportunities to modulate this emergent drug modality in a clinical setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2014.24DOI Listing
January 2015
5 Reads

Genetic basis of human left-right asymmetry disorders.

Expert Rev Mol Med 2015 Jan 27;16:e19. Epub 2015 Jan 27.

Center for Experimental Medicine and Department of Neurology,the Third Xiangya Hospital, Central South University,Changsha 410013,China.

Humans and other vertebrates exhibit left-right (LR) asymmetric arrangement of the internal organs, and failure to establish normal LR asymmetry leads to internal laterality disorders, including situs inversus and heterotaxy. Situs inversus is complete mirror-imaged arrangement of the internal organs along LR axis, whereas heterotaxy is abnormal arrangement of the internal thoraco-abdominal organs across LR axis of the body, most of which are associated with complex cardiovascular malformations. Both disorders are genetically heterogeneous with reduced penetrance, presumably because of monogenic, polygenic or multifactorial causes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2014.22DOI Listing
January 2015
4 Reads

The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications.

Expert Rev Mol Med 2015 Jul 2;17:e14. Epub 2015 Jul 2.

Scientific Direction,Regina Elena National Cancer Institute,Rome,Italy.

The Hippo signalling is emerging as a tumour suppressor pathway whose function is regulated by an intricate network of intracellular and extracellular cues. Defects in the signal cascade lead to the activation of the Hippo transducers TAZ and YAP. Compelling preclinical evidence showed that TAZ/YAP are often aberrantly engaged in breast cancer (BC), where their hyperactivation culminates into a variety of tumour-promoting functions such as epithelial-to-mesenchymal transition, cancer stem cell generation and therapeutic resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.12DOI Listing
July 2015
24 Reads

Detection of skewed X-chromosome inactivation in Fragile X syndrome and X chromosome aneuploidy using quantitative melt analysis.

Expert Rev Mol Med 2015 Jul 1;17:e13. Epub 2015 Jul 1.

Cyto-molecular Diagnostic Research Laboratory,Victorian Clinical Genetics Services and Murdoch Children's Research Institute,Royal Children's Hospital,Melbourne,Victoria,3052,Australia.

Methylation of the fragile X mental retardation 1 (FMR1) exon 1/intron 1 boundary positioned fragile X related epigenetic element 2 (FREE2), reveals skewed X-chromosome inactivation (XCI) in fragile X syndrome full mutation (FM: CGG > 200) females. XCI skewing has been also linked to abnormal X-linked gene expression with the broader clinical impact for sex chromosome aneuploidies (SCAs). In this study, 10 FREE2 CpG sites were targeted using methylation specific quantitative melt analysis (MS-QMA), including 3 sites that could not be analysed with previously used EpiTYPER system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2015.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836209PMC
July 2015
64 Reads

Costamere proteins and their involvement in myopathic processes.

Expert Rev Mol Med 2015 Jun 19;17:e12. Epub 2015 Jun 19.

Neurosciences Area,BioDonostia Institute,Paseo Dr. Begiristain s/n,20014 San Sebastián,Spain.

Muscle fibres are very specialised cells with a complex structure that requires a high level of organisation of the constituent proteins. For muscle contraction to function properly, there is a need for not only sarcomeres, the contractile structures of the muscle fibre, but also costameres. These are supramolecular structures associated with the sarcolemma that allow muscle adhesion to the extracellular matrix. Read More

View Article

Download full-text PDF

Source
http://www.journals.cambridge.org/abstract_S1462399415000095
Publisher Site
http://dx.doi.org/10.1017/erm.2015.9DOI Listing
June 2015
12 Reads