996 results match your criteria Expert Review of Respiratory Medicine [Journal]


The role of immune checkpoint inhibitors in advanced non-small cell lung cancer.

Expert Rev Respir Med 2019 Mar 14. Epub 2019 Mar 14.

c Dpt of Medical Oncology , University Hospital of Larissa.

Introduction: Cancer immunotherapy represents a major therapeutic breakthrough. Immune checkpoint inhibitors alone or in the context of a combination are considered the new standard of care in advanced non-small cell lung cancer (NSCLC). Areas covered: This review explains the biologic rationale behind the implementation of immune checkpoint inhibitors for the therapy of advanced NSCLC. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1593828DOI Listing
March 2019
1 Read

E-cigarette use and subsequent smoking in adolescents and young adults: a perspective.

Expert Rev Respir Med 2019 Mar 1:1-3. Epub 2019 Mar 1.

a Department of Health Sciences , University of York , Heslington , York , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1589371DOI Listing

Advances in synthetic lung surfactant protein technology.

Expert Rev Respir Med 2019 Feb 28:1-3. Epub 2019 Feb 28.

a David Geffen School of Medicine , University of California Los Angeles , Los Angeles , CA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1589372DOI Listing
February 2019
1 Read

Drowning is never dry.

Expert Rev Respir Med 2019 Feb 28:1-3. Epub 2019 Feb 28.

c Department of Pediatrics , University of Washington School of Medicine , Seattle , WA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1589373DOI Listing
February 2019
1 Read

Emerging approaches in pediatric mechanical ventilation.

Expert Rev Respir Med 2019 Feb 26. Epub 2019 Feb 26.

b Division of Pediatric Critical Care Medicine, Department of Pediatrics , Duke Children's Hospital , Durham , NC , USA.

Introduction: The use of mechanical ventilation is an invaluable tool in caring for critically ill patients. Enhancing our capabilities in mechanical ventilation has been instrumental in the ability to support clinical conditions and diseases which were once associated with a high mortality. Areas covered: Within this manuscript, we will look to discuss emerging approaches to improving the care of pediatric patients who require mechanical ventilation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1586536DOI Listing
February 2019

Diagnosing and managing bronchiolitis obliterans in children.

Expert Rev Respir Med 2019 Feb 23:1-8. Epub 2019 Feb 23.

a Respiratory Unit , Great Ormond Street Hospital for Children NHS Foundation Trust , London , UK.

Introduction: Bronchiolitis obliterans (BO) is a chronic and irreversible obstructive lung disease leading to the obstruction and/or obliteration of the small airways. Three main BO entities are distinguished: post-infectious BO (PIBO); BO post lung transplantation; and BO after bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT). All three entities are separate, however, there are similarities in histopathological characteristics and possibly in aspects of the development pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1586537DOI Listing
February 2019
1 Read

Emphysema: looking beyond alpha-1 antitrypsin deficiency.

Expert Rev Respir Med 2019 Feb 14:1-17. Epub 2019 Feb 14.

b Department of Respiratory Medicine , Maastricht University Medical Center , Maastricht , The Netherlands.

Introduction: Distinct pathologies can cause chronic obstructive pulmonary disease (COPD). Emphysema is a COPD-phenotype characterized by destruction of lung parenchyma. Alpha-1 antitrypsin deficiency (AATD) is a genetic cause of emphysema, whereas smoking is the most important risk factor of non-AATD emphysema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1580575DOI Listing
February 2019
4 Reads

Accelerated lung aging and chronic obstructive pulmonary disease.

Expert Rev Respir Med 2019 Feb 8:1-12. Epub 2019 Feb 8.

a Centre for Heart and Lung Innovation , St. Paul's Hospital & University of British Columbia , Vancouver , BC , Canada.

Introduction: The prevalence of chronic obstructive pulmonary disease (COPD) increases exponentially with aging. Its pathogenesis, however, is not well known and aside from smoking cessation, there are no disease-modifying treatments for this disease. Areas covered: COPD is associated with accelerating aging and aging-related diseases. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1580576DOI Listing
February 2019
5 Reads

Mechanisms how mucosal innate immunity affects progression of allergic airway disease.

Authors:
Allan R Brasier

Expert Rev Respir Med 2019 Feb 4:1-8. Epub 2019 Feb 4.

a Institute for Clinical and Translational Research , University of Wisconsin-Madison School of Medicine and Public Health , Madison , WI , USA.

Introduction: Activation of antigen-independent inflammation (a.k.a. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1578211DOI Listing
February 2019
1 Read

Pleural infection: a closer look at the etiopathogenesis, microbiology and role of antibiotics.

Expert Rev Respir Med 2019 Feb 1:1-11. Epub 2019 Feb 1.

a Oxford Pleural Unit , Oxford University Hospitals , Oxford , UK.

Introduction: Pleural infection is a condition that continues to pose a significant challenge to respiratory physicians. We hypothesize that the main barriers to progress include limited understanding of the etiopathogenesis, microbiology,and role of antibiotics in the pleural space. Areas covered: PubMed was searched for articles related to adult pleural infection using the terms 'pleural infection', 'empyema' and 'parapneumonic'. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1578212DOI Listing
February 2019
2 Reads

Is positive airway pressure therapy underutilized in chronic obstructive pulmonary disease patients?

Expert Rev Respir Med 2019 Feb 1:1-9. Epub 2019 Feb 1.

b Division of Pulmonary, Allergy, Critical Care & Sleep Medicine , University of Arizona - Medicine , Tucson , AZ , USA.

Introduction: The role of noninvasive positive pressure ventilation (NIPPV) in patients with stable chronic obstructive pulmonary disease (COPD) in the home-setting remains controversial. Despite studies suggesting potential benefits, there is an apparent underutilization of such therapy in patients with stable COPD in a domiciliary setting. Areas covered: The reasons for underutilization in the home-setting are multifactorial, and we provide our perspective on the adequacy of scientific evidence and implementation barriers that may underlie the observed underutilization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1577732DOI Listing
February 2019
3 Reads

Obstructive sleep apnoea and comorbidity - an overview of the association and impact of continuous positive airway pressure therapy.

Expert Rev Respir Med 2019 Mar 11;13(3):251-261. Epub 2019 Feb 11.

a Department of Respiratory and Sleep Medicine, St. Vincent's Hospital Group and School of Medicine , University College Dublin , Dublin , Ireland.

Introduction: Obstructive sleep apnoea (OSA) is highly prevalent and there is considerable evidence supporting an independent association with a wide range of co-morbidities including cardiovascular, endocrine and metabolic, neuropsychiatric, pulmonary, and renal. Areas covered: A PubMed search of all the recent literature relating to OSA and co-morbidities was undertaken to critically evaluate the potential relationships and possible benefit of continuous positive airway pressure (CPAP) therapy. Expert commentary: The evidence supporting an independent association is stronger for some co-morbidities than others and in cardiovascular diseases is strongest for hypertension and atrial fibrillation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1575204DOI Listing
March 2019
2 Reads

Upper airway resistance syndrome 2018: non-hypoxic sleep-disordered breathing.

Expert Rev Respir Med 2019 Jan 28:1-10. Epub 2019 Jan 28.

a Sleep Medicine , Stanford University , Redwood City , CA , USA.

Introduction: Upper airway resistance syndrome (UARS) as obstructive sleep apnea syndrome (OSAS) has been described as abnormal breathing during sleep, based on the recording technologies and knowledge of the time. These terms have advanced the field, but are they still useful? Area Covered: Historically, the definition of UARS syndrome was aimed at recognizing pathology not covered by 'OSAS' and to prompt specialists to go further than the obvious. It aimed at pushing specialists to recognize pathologies earlier and to elicit research in the developmental features of sleep-disordered-breathing (SDB). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1575731DOI Listing
January 2019
2 Reads

Caveolae, caveolin-1 and lung diseases of aging.

Expert Rev Respir Med 2019 Mar 7;13(3):291-300. Epub 2019 Feb 7.

a Department of Physiology and Biomedical Engineering , Mayo Clinic , Rochester , MN , USA.

Introduction: Flask-shaped plasma membrane (PM) invaginations called caveolae and their constitutive caveolin and cavin proteins regulate cellular function via plasma membrane and intracellular signal transduction pathways. Caveolae are present in a variety of cells in the lung including airway smooth muscle (ASM) where they interact with other proteins, receptors, and ion channels and thereby have the potential to affect both normal and disease processes such as inflammation, contractility, and fibrosis. Given their involvement in cell signaling, caveolae may play important roles in mediating and modulating aging processes, and contribute to lung diseases of aging. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1575733DOI Listing
March 2019
4 Reads

Scleroderma-related interstitial lung disease: principles of management.

Expert Rev Respir Med 2019 Jan 28:1-11. Epub 2019 Jan 28.

e Respiratory Institute , Cleveland Clinic , Cleveland , OH , USA.

Introduction: Interstitial lung disease (ILD) is the most common cause of mortality in systemic sclerosis; accounting for approximately 35% of deaths. Although immunosuppression is currently opted as first line therapy for scleroderma-related ILD (SSc-ILD), the benefits from it remain modest with concerns for systemic toxicity from long term use. Areas covered: We review the important facets in monitoring a patient with SSc-ILD, including recognizing various patterns of ILD, identifying those at risk for disease progression and discuss the strength of evidence for immunosuppressant drugs and lung transplantation. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1575732DOI Listing
January 2019
12 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
2 Reads

Advances in the diagnosis, treatment, and prevention of tuberculosis in children.

Authors:
Jennifer Furin

Expert Rev Respir Med 2019 Mar 22;13(3):301-311. Epub 2019 Jan 22.

a Harvard Medical School , Department of Global Health and Social Medicine , Boston , MA , USA.

Introduction: Pediatric tuberculosis (TB) is a significant global health threat and is one of the top ten causes of death in children. There are a number of diagnostic, treatment, and preventive innovations that have been developed in the last decade for TB, however, these are out of reach for many children in the world. Areas covered: A comprehensive review of the literature on TB in children was done using PubMed and Ovid databases from 1 January 1996 up to 31 October 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1569518DOI Listing
March 2019
3 Reads

Diagnosis of asbestos-related lung diseases.

Expert Rev Respir Med 2019 Mar 25;13(3):241-249. Epub 2019 Jan 25.

a Department of Respiratory Medicine , Sir Charles Gairdner Hospital , Perth , WA , Australia.

Introduction: The diagnosis of lung disease in asbestos-exposed individuals is a process that not only requires a detailed occupational and tobacco smoking history, but the correlation with physical signs, appropriate imaging, detailed lung function assessment and histology/cytology when required. Worldwide, the total quantity of asbestos mined is static, having decreased dramatically in developed countries but increased in countries where there is no restriction on mining: for example, Russia, China, Brazil, and Kazakhstan. The predominant diagnostic challenge in most cases of possible asbestos-related disease is the significant interval between exposure and development of the disease. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1568875DOI Listing
March 2019
9 Reads

Diagnosis and first-line treatment of non-small cell lung cancer in the era of novel immunotherapy: recommendations for clinical practice.

Expert Rev Respir Med 2019 Mar 24;13(3):217-228. Epub 2019 Jan 24.

j Division of Medical Oncology , 'S. G. Moscati' Hospital , Avellino , Italy.

Introduction: In the era of personalized cancer therapy, the sampling of adequate tumor tissue for histologic diagnosis and genomic profiling is crucial, not only at the initial diagnosis but also in the event of resistant and recurrent disease when sequential biopsies may be required to evaluate somatic mutations and histologic changes. Areas covered: The identification of genetic driver alterations led to the selection of patients who are most likely to benefit from epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) and rat osteosarcoma (ROS-1) tyrosine kinase inhibitors; on the other hand, in the absence of oncogenic alterations, platinum-based doublet chemotherapy regimens were the cornerstone of treatment. However, the advent of immunotherapy has widely changed the first-line treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1569517DOI Listing
March 2019
4 Reads

Direct bronchoprovocation test methods: history 1945-2018.

Expert Rev Respir Med 2019 Mar 24;13(3):279-289. Epub 2019 Jan 24.

a Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine , University of Saskatchewan.

Introduction: Bronchoprovocation inhalation challenge tests with direct acting stimuli (e.g. methacholine) are widely used clinically to aid in the diagnosis of asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1568245DOI Listing
March 2019
1 Read

Existing and emerging treatments for idiopathic pulmonary fibrosis.

Expert Rev Respir Med 2019 Mar 21;13(3):229-239. Epub 2019 Jan 21.

c First Academic Department of Pneumonology, Interstitial Lung Diseases Unit , Hospital for Diseases of the Chest, "Sotiria", Medical School, National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive and invariable fatal interstitial lung disease. Current antifibrotic treatment halts disease progression but does not cure the disease itself. In the last decade, a substantial understanding of disease pathobiological mechanisms led to the development of numerous clinical trials testing promising pharmacologic agents. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1568244DOI Listing
March 2019
16 Reads

Asthma patient satisfaction with different dry powder inhalers.

Expert Rev Respir Med 2019 Feb 21;13(2):133-138. Epub 2019 Jan 21.

f Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau. Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau) , Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Universitat Autònoma de Barcelona, Department of Medicine , Barcelona , Spain.

Background: The preferences and opinions of patients are important when choosing the optimal inhaler device for asthma management. We compared patient satisfaction of three dry powder inhalers in patients with moderate to severe asthma.

Methods: We selected a group of patients treated with Easyhaler (n = 164) and a second group of patients treated with Turbuhaler (n = 100) or Diskus (Accuhaler) (n = 64) from the register of an observational, multicenter study. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1567339DOI Listing
February 2019
7 Reads

The role of ultrasound lung artifacts in the diagnosis of respiratory diseases.

Expert Rev Respir Med 2019 Feb 10;13(2):163-172. Epub 2019 Jan 10.

d Department of Information Engineering and Computer Science , University of Trento , Trento , Italy.

Introduction: Thoracic ultrasound is employed for the diagnosis of many thoracic diseases and is an accepted detection tool of pleural effusions, atelectasis, pneumothorax, and pneumonia. However, the use of ultrasound for the evaluation of parenchymal lung disease, when the organ is still aerated, is a relatively new application. Areas covered: The diagnosis of a normal lung and the differentiation between a normally aerated lung and a lung with interstitial pathology is based on the interpretation of ultrasound artifacts universally known as A and B-Lines. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1565997DOI Listing
February 2019
35 Reads

An update on current and emerging treatments for pulmonary arterial hypertension in childhood and adolescence.

Expert Rev Respir Med 2019 Feb 11;13(2):205-215. Epub 2019 Jan 11.

b Pediatric Cardiology Unit , University Children's Hospital HUG, Pulmonary Hypertension Program HUG, Centre Universitaire Romand de Cardiologie et Chirurgie Cardiaque Pédiatrique (CURCCCP), University of Geneva and Lausanne , Geneva and Lausanne , Switzerland.

Introduction: Pulmonary hypertension is a severe condition that can develop during childhood due to several different etiologies. During the last two decades, based on a better understanding of the underlying pathobiology leading to pulmonary arterial hypertension, targeted therapies have been developed and have improved the dreadful prognosis of the condition. However, curative therapy remains elusive. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1565998DOI Listing
February 2019
5 Reads

Defining the aetiology of paediatric community-acquired pneumonia: an unsolved problem.

Expert Rev Respir Med 2019 Feb 2;13(2):153-161. Epub 2019 Jan 2.

b Università degli Studi di Milano , Milan , Italy.

Introduction: Pediatric community-acquired pneumonia (CAP) remains a significant health problem worldwide. Although knowledge in the etiology of CAP is not satisfactory, in most cases, therapy is decided following probability-based criteria that are derived from studies that report the frequency of detection of pathogens in children with CAP. Areas covered: This narrative review discusses the present knowledge on pediatric CAP etiology, the limits of the aetiological studies and the tests for differentiation of viral from bacterial infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1562341DOI Listing
February 2019
2 Reads

The burden of community-acquired bacterial pneumonia in the era of antibiotic resistance.

Expert Rev Respir Med 2019 Feb 30;13(2):139-152. Epub 2018 Dec 30.

d GST Micro LLC , Henrico , VA , USA.

Introduction: Community-acquired pneumonia (CAP) is a significant global health problem and leading cause of death and hospitalization in both the US and abroad. Increasing macrolide resistance among Streptococcus pneumoniae and other pathogens results in a greater disease burden, along with changing demographics and a higher preponderance of comorbid conditions. Areas covered: This review summarizes current data on the clinical and economic burden of CAP, with particular focus on community-acquired bacterial pneumonia (CABP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1562339DOI Listing
February 2019
4 Reads

Mirtazapine for chronic breathlessness? A review of mechanistic insights and therapeutic potential.

Expert Rev Respir Med 2019 Feb 30;13(2):173-180. Epub 2018 Dec 30.

a Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation , King's College London , London , UK.

Introduction: Chronic breathlessness is a common and distressing symptom of advanced disease with few effective treatments. Central nervous system mechanisms are important in respiratory sensation and control. Consequently, drugs which may modify processing and perception of afferent information in the brain may have a role. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1563486DOI Listing
February 2019
3 Reads

Immunotherapy strategies for mesothelioma - the role of tumor specific neoantigens in a new era of precision medicine.

Expert Rev Respir Med 2019 Feb 30;13(2):181-192. Epub 2018 Dec 30.

b National Centre for Asbestos Related Disease , University of Western Australia , Nedlands , Australia.

Introduction: Immunotherapy has long been considered a potential therapy for malignant mesothelioma and is currently being pursued as such. Some of the early phase clinical trials involving immunomodulators have demonstrated encouraging results and numerous clinical trials are underway to further investigate this treatment approach in various treatment settings and larger patient cohorts. Areas covered: This review summarizes the current and emerging clinical evidence for checkpoint blockade and other immunotherapeutic strategies in mesothelioma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1563488DOI Listing
February 2019
4 Reads

Modulating airway glucose to reduce respiratory infections.

Expert Rev Respir Med 2019 Feb 7;13(2):121-124. Epub 2019 Jan 7.

b Airway Disease Infection Section, National Heart and Lung Institute , Imperial College , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1563487DOI Listing
February 2019
2 Reads

Clinical considerations when treating neonatal aspiration syndromes.

Expert Rev Respir Med 2019 Feb 2;13(2):193-203. Epub 2019 Jan 2.

c Clinic of Neonatology, Jessenius Faculty of Medicine , Comenius University and University Hospital Martin , Martin , Slovakia.

Introduction: In physiological conditions, neonatal airways are well-protected against aspiration of fluid or particulate material into the lungs, with laryngeal chemoreflex (LCR) being the most powerful mechanism. Failure of this protection allows substances to enter the lower airways, which starts a series of pathophysiological events initiated by inflammation and surfactant inactivation. The condition is defined as neonatal acute respiratory distress syndrome (ARDS), and its symptoms can range from mild respiratory distress to respiratory failure, often accompanied by persistent pulmonary hypertension (PPHN), in turn even leading to death. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1562340DOI Listing
February 2019
17 Reads

Mepolizumab for the prevention of chronic obstructive pulmonary disease exacerbations.

Expert Rev Respir Med 2019 Feb 30;13(2):125-132. Epub 2018 Dec 30.

a Department of Thoracic Medicine and Surgery , Lewis Katz School of Medicine at Temple University , Philadelphia , PA , USA.

Introduction: Worldwide chronic obstructive pulmonary disease (COPD) is the third most common cause of non-communicable deaths. The pathobiology of the disease is predominantly neutrophilic but there is a subset of patients with elevated peripheral eosinophil count that respond better to inhaled and systemic corticosteroids currently being classified as eosinophilic phenotype. This review focuses on the role of mepolizumab, a fully humanized monoclonal antibody against IL-5 molecule that regulates the eosinophil life cycle, in the management of patients with this phenotype of COPD. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1561287DOI Listing
February 2019
23 Reads

Managing pulmonary complications in allogeneic hematopoietic stem cell transplantation.

Expert Rev Respir Med 2018 Dec 7. Epub 2018 Dec 7.

a Service de Pneumologie , AP-HP, Hôpital Saint-Louis , F-75010 , Paris , France.

Introduction: Progress in allogeneic hematopoietic stem cell transplantation (HSCT) procedures have been associated with improved survival in HSCT recipients. However, they have also brought to light organ-specific complications, especially pulmonary complications. In this setting, pulmonary complications are consistently associated with poor outcomes, and improved management of these complications is required. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1557049DOI Listing
December 2018
9 Reads

Existing and emerging biomarkers for disease progression in idiopathic pulmonary fibrosis.

Expert Rev Respir Med 2019 Jan 17;13(1):39-51. Epub 2018 Dec 17.

a Pulmonary Medicine Unit, Department of Cardiovascular and Thoracic Sciences , Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome , Italy.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure, and ultimately to death. It is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, the course of the disease and the response to treatment of an individual patient cannot be reliably predicted today. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1553620DOI Listing
January 2019
2 Reads

Epidemiology of lower respiratory tract infections in adults.

Expert Rev Respir Med 2018 Dec 6. Epub 2018 Dec 6.

b Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa .

Introduction: Lower respiratory tract infections (LRTIs) are the leading infectious disease cause of death in the world and the fifth overall cause of death. From an epidemiological point of view, most consider pneumonia, influenza, bronchitis (including acute exacerbations in chronic obstructive pulmonary disease [AECOPD]), and bronchiolitis to be the most important LRTIs. Areas covered: This review will describe the epidemiology of LRTIs in adults focusing on community-acquired pneumonia, influenza, and AECOPD, utilizing data from the more recent literature. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1555040DOI Listing
December 2018
13 Reads

Adherence to treatment in allergic respiratory diseases.

Expert Rev Respir Med 2018 Dec 5:1-10. Epub 2018 Dec 5.

a Department of Biomedical Sciences , Humanitas University , Milano , Italy.

Introduction: Asthma and allergic rhinitis (AR) are chronic conditions in which management needs adherence to prescribed drugs. Despite the benefits of regular maintenance of asthma and AR therapy, low adherence is a frequent issue in clinical practice. Areas covered: The aim of this review is to provide a targeted analysis of the more recent literature on adherence in asthma and AR, focused on the following areas: adherence extent, barriers and consequences, effects of educational interventions and use of new technologies to improve the level of adherence. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2019.1554438DOI Listing
December 2018
12 Reads

The place of high-resolution computed tomography imaging in the investigation of interstitial lung disease.

Expert Rev Respir Med 2019 Jan 12;13(1):79-94. Epub 2018 Dec 12.

a Université Paris 13, EA2363 "Hypoxie & Poumon" , Sorbonne-Paris-Cité , Bobigny, France.

Introduction: High-resolution computed tomography (HRCT) has revolutionized the diagnosis, prognosis and in some cases the prediction of therapeutic response in interstitial lung disease (ILD). HRCT represents an essential second step to a patient's clinical history, before considering any other investigation, including lung biopsy. Areas covered: This review describes the current place of HRCT in the diagnosis, prognosis and monitoring of ILD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1556639DOI Listing
January 2019
11 Reads

Therapeutic strategies for pediatric bronchiolitis.

Authors:
Matti Korppi

Expert Rev Respir Med 2019 Jan 5;13(1):95-103. Epub 2018 Dec 5.

a Center for Child health Research, Tampere University and University Hospital, Finland Arvo2 building , Tampere University , Tampere , Finland.

Introduction: Bronchiolitis in infancy is the most common infectious reason for hospitalization of infants without any chronic underlying illness. Areas covered: This review focuses on the role of racemic epinephrine, systemic corticosteroids, hypertonic saline and high-flow oxygen therapy (HFOT) in the treatment of infants with bronchiolitis. Literature was searched from Pubmed covering the years 2009-2018 using the entries of bronchiolitis or viral bronchiolitis, and epinephrine, adrenaline, racemic epinephrine, racemic adrenaline, corticosteroids, hypertonic saline, high-flow oxygen therapy, or high-flow oxygen cannula. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1554439DOI Listing
January 2019
3 Reads

Current perspectives of physical activity in cystic fibrosis.

Expert Rev Respir Med 2018 Nov 28. Epub 2018 Nov 28.

a Discipline of Physiotherapy , La Trobe University , 99 Commercial Road Melbourne 3004 Victoria , Australia.

Introduction: Regular exercise and physical activity participation are recommended in guideline-based care for individuals with cystic fibrosis (CF) across the spectrum of age and disease severity. However, the best training methods to improve physical function and encourage ongoing exercise and activity participation are not clear, which is an ongoing challenge for clinicians. Areas covered: This perspective provides an overview of current evidence for exercise and physical activity relative to clinical outcomes and healthcare utilisation in people with CF, and highlights areas of future research need. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1552833DOI Listing
November 2018
2 Reads

Acute and chronic non-pulmonary complications in adults with cystic fibrosis.

Expert Rev Respir Med 2019 Jan 30;13(1):23-38. Epub 2018 Nov 30.

a Faculté de Médecine , Paris Descartes University , Sorbonne Paris Cité , Paris , France.

Introduction: Cystic fibrosis (CF) is a genetic disease that primarily affects the respiratory system and often leads to respiratory failure and premature death. Although pulmonary complications contribute to 85% of deaths, non-pulmonary complications are responsible for significant morbidity and mortality in adults with CF. Areas covered: This review summarizes acute and chronic non-pulmonary complications in CF patients, with emphasis on emerging complications and in the context of the current growth and aging of the CF adult population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1552832DOI Listing
January 2019
3 Reads

Beclomethasone dipropionate, formoterol fumarate and glycopyrronium bromide as a combination therapy for chronic obstructive pulmonary disease.

Expert Rev Respir Med 2019 Jan 27;13(1):5-11. Epub 2018 Nov 27.

a Department of Internal Medicine, Asthma and Allergy , Medical University of Lodz , Lodz , Poland.

Introduction: The triple therapy term covers the combination of inhaled corticosteroid (ICS), long-acting β-receptor agonist (LABA) and long-acting anticholinergic drug (LAMA) in one or in separate inhalers. The latest GOLD 2018 (Global Initiative for Chronic Obstructive Disease) guidelines recommend the triple therapy in the management of chronic obstructive pulmonary disease (COPD) in patients of group D who despite the combination of two drugs: LAMA/LABA or ICS/LABA continue to have persistent symptoms or suffer from further frequent exacerbations. Areas covered: The first triple fixed-dose combination of extrafine beclomethasone/formoterol/glycopyrronium in one pMDI type inhaler intended for the treatment of COPD has been registered in Europe in 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1548937DOI Listing
January 2019
17 Reads

Fluticasone furoate, umeclidinium bromide, and vilanterol as a combination therapy for chronic obstructive pulmonary disease.

Expert Rev Respir Med 2018 Nov 21:1-9. Epub 2018 Nov 21.

a Department of Surgery, Medicine, Molecular Biology and Critical Care , University of Pisa , Pisa , Italy.

Introduction: Triple therapy with two bronchodilators (LABA plus LAMA) and an inhaled corticosteroid (ICS) is recommended for patients suffering from severe chronic obstructive pulmonary disease (COPD). Areas covered: All 12-52 week-long studies comparing triple therapy with umeclidinium (UM) added to either fluticasone furoate/vilanterol (FF/VI) or fluticasone propionate/salmeterol (FP/SAL) vs. other comparators in COPD patients of group B or D (2011 GOLD classification) were considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2018.1548936DOI Listing
November 2018
12 Reads

Limiting ventilator-associated complications in ICU intubated subjects: strategies to prevent ventilator-associated events and improve outcomes.

Expert Rev Respir Med 2018 Nov 21:1-14. Epub 2018 Nov 21.

d Clinical Research/epidemiology In Pneumonia & Sepsis , Vall d'Hebron Institut of Research & Centro de Investigacion Biomedica en Red (CIBERES) , Barcelona , Spain.

Introduction: Intubation is required to maintain the airways in comatose patients and enhance oxygenation in hypoxemic or ventilation in hypercapnic subjects. Recently, the Centers of Disease Control (CDC) created new surveillance definitions designed to identify complications associated with poor outcomes. Areas covered: The new framework proposed by CDC, Ventilator-Associated Events (VAE), has a range of definitions encompassing Ventilator-Associated Conditions (VAC), Infection-related Ventilator-Associated Complications (IVAC), or Possible Ventilator-Associated Pneumonia - suggesting replacing the traditional definitions of Ventilator-Associated Tracheobronchitis (VAT) and Ventilator-Associated Pneumonia (VAP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2018.1549492DOI Listing
November 2018
25 Reads

Clinical presentation and treatment of catameinal pneumothorax and endometriosis-related pneumothorax.

Expert Rev Respir Med 2018 Nov 20:1-6. Epub 2018 Nov 20.

a Thoracic surgery department, Paris center hospitals , University Paris Descartes, APHP , Paris , France.

Introduction: Catamenial pneumothorax (CP) is defined as a recurrent spontaneous pneumothorax occurring in females of reproductive age. In the 'perimenstrual period,' it is still considered relatively rare although accounting for 20-35% of spontaneous pneumothoraces occurring in premenopausal women. It is the most frequent manifestation of thoracic endometriosis, which can also cause pneumothorax during the intermenstrual period (TER non-CP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2018.1551133DOI Listing
November 2018
12 Reads

Is bronchoscopic treatment of lung cancer possible?

Expert Rev Respir Med 2019 Jan 20;13(1):1-3. Epub 2018 Nov 20.

a Interventional Pulmonology, Division of Pulmonary and Critical Care Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2019.1549493DOI Listing
January 2019
2 Reads

The acute respiratory distress syndrome: pathophysiology, current clinical practice, and emerging therapies.

Expert Rev Respir Med 2018 Dec 21;12(12):1021-1029. Epub 2018 Nov 21.

a Klinik für Anästhesiologie , Uniklinik RWTH Aachen, Medizinische Fakultät RWTH Aachen , Aachen , Germany.

Introduction: More than fifty years after the first description of acute respiratory distress syndrome (ARDS) by Ashbaugh and colleagues, no specific treatment of the underlying pathophysiological processes is available. The current therapeutic regime is comprised of supportive measures such as lung protective ventilation, restrictive fluid management, paralyzing drugs, and prone positioning. Although vast improvements have been made in ARDS-treatment during the last five decades, mortality among patients with severe ARDS remains at an unacceptable rate of 45%. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2018.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2018.1548280DOI Listing
December 2018
22 Reads

Can a temporary increase in corticosteroid dosage reduce asthma exacerbations?

Expert Rev Respir Med 2018 Nov 12:1-3. Epub 2018 Nov 12.

a NIHR Respiratory Biomedical Research Centre , University of Nottingham , Nottingham , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2018.1547636DOI Listing
November 2018
2 Reads

Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea.

Expert Rev Respir Med 2018 Nov 2:1-13. Epub 2018 Nov 2.

a Department of Psychiatry & Behavioral Sciences, Division of Sleep Medicine , Stanford University , Redwood City , CA , USA.

Introduction: Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibitor, is the first drug of its class that is being considered by the US Food and Drug Administration (FDA) to treat excessive sleepiness in OSA and narcolepsy patients. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2018.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2018.1541742DOI Listing
November 2018
34 Reads

Sex, smoking and body mass index: do they aid in uncovering the complex mechanisms behind airway hyperresponsiveness?

Expert Rev Respir Med 2018 Oct 26:1-3. Epub 2018 Oct 26.

a Department of Epidemiology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2018.1541741DOI Listing
October 2018
2 Reads

Chronic interstitial lung diseases in children: diagnosis approaches.

Expert Rev Respir Med 2018 Oct 22:1-10. Epub 2018 Oct 22.

a Service de pneumologie pédiatrique, Centre national de référence des maladies respiratoires rares RespiRare , Hôpital Armand Trousseau, Assistance Publique Hôpitaux de Paris (AP-HP) , Paris , France.

Introduction: Children interstitial lung disease (chILD) is a heterogeneous group of rare respiratory disorders characterized by inflammatory and fibrotic changes of the lung parenchyma. They include ILD related to exposure/environment insults, ILD related to systemic diseases processes, ILD related to primary lung parenchyma dysfunctions and ILD specific to infancy. Areas covered: This review provides an update on chILD pathophysiology and diagnosis approaches in immunocompetent children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17476348.2018.1538795DOI Listing
October 2018
8 Reads

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions.

Expert Rev Respir Med 2018 Oct 8:1-14. Epub 2018 Oct 8.

a Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism , Maastricht University Medical Centre+ , Maastricht , The Netherlands.

Introduction: Cognitive impairment (CI) is an important but an under-recognized extra-pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the burden of disability, worse health outcomes, and impaired self-management. Areas covered: CI includes deterioration of a wide range of cognitive functions, such as memory and various executive functions. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17476348.2018.1
Publisher Site
http://dx.doi.org/10.1080/17476348.2018.1533405DOI Listing
October 2018
4 Reads