128,213 results match your criteria Expert Review of Respiratory Medicine [Journal]


[Recommendations from a panel of experts on the usefulness of fidaxomicin for the treatment of infections caused by Clostridium difficile].

Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.

Benito Almirante, Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron Passeig de la Vall d'Hebron, 119-129 - 08035 Barcelona, Spain.

Objective: Clostridium difficile infections have a high recurrence rate, which can complicate the prognosis of affected patients. It is therefore important to establish an early detection and an appropriate therapeutic strategy. The objective of this manuscript was to gather the opinion of an expert group about the predictive factors of poor progression, as well as when to use fidaxomicin in different groups of high-risk patients. Read More

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December 2018

Robotic versus freehand S2 alar iliac fixation: in-depth technical considerations.

J Spine Surg 2018 Sep;4(3):638-644

Department of Orthopedic Surgery, Norton Leatherman Spine Center, Louisville, KY, USA.

Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. Read More

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September 2018

An AI-Based Heart Failure Treatment Adviser System.

IEEE J Transl Eng Health Med 2018 23;6:2800810. Epub 2018 Nov 23.

Computer Science DepartmentThe University of Texas at DallasRichardsonTX75080USA.

Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines are nearly 80 pages long. Read More

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November 2018

Clinical trial design and new therapies for pulmonary arterial hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

San Diego School of Medicine, University of California, La Jolla, CA, USA.

Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on case reports and small series, and was largely ineffectual. As a deeper understanding of the pathogenesis and pathophysiology of PAH evolved over the subsequent two decades, coupled with epidemiological studies defining the clinical and demographic characteristics of the condition, a renewed interest in treatment development emerged through collaborations between international experts, industry and regulatory agencies. These efforts led to the performance of robust, high-quality clinical trials of novel therapies that targeted putative pathogenic pathways, leading to the approval of more than 10 novel therapies that have beneficially impacted both the quality and duration of life. Read More

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December 2018
1 Read

Diagnosis of pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Pulmonary Circulation and Cardidology, Medical Center for Postgraduate Education, ECZ-Otwock, Otwock, Poland.

A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed. Read More

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December 2018

Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.

Pharmacol Rev 2019 Jan 13;71(1):1-19. Epub 2018 Dec 13.

Genomic Medicine Institute, Lerner Research Institute (F.C., C.E.) and Taussig Cancer Institute (C.E.), Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (F.C., C.E.); CASE Comprehensive Cancer Center (F.C., C.E.) and Department of Genetics and Genome Sciences (C.E.), Case Western Reserve University School of Medicine, Cleveland, Ohio; Departments of Bioinformatics and Computational Biology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (H.L.); Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California (A.J.B.); Center for Data-Driven Insights and Innovation, University of California Health, Oakland, California (A.J.B.); Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland (R.N.); and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (R.N.)

Recent remarkable advances in genome sequencing have enabled detailed maps of identified and interpreted genomic variation, dubbed "mutanomes." The availability of thousands of exome/genome sequencing data has prompted the emergence of new challenges in the identification of novel druggable targets and therapeutic strategies. Typically, mutanomes are viewed as one- or two-dimensional. Read More

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January 2019

Ex-vivo and in vitro validation of an innovative mandibular condyle implant concept.

J Craniomaxillofac Surg 2018 Nov 16. Epub 2018 Nov 16.

University of Bordeaux, Institut de Mécanique et d'Ingénierie, CNRS UMR 5295, FR-33405 Talence, France.

Purpose: The purpose of this study is to pre-validate an inovative implant concept, and to compare the behavior of the mandibular condyle against a commercial Biomet implant in an ex vivo model and present results of the first cadaveric studies.

Materials And Methods: Three experimental cadaveric condyles were tested under three conditions: one intact, another with the Biomet model, and one with the innovative concept. The condyle was tested with a reaction of 300 N in all situations and the principal strains were measured. Read More

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November 2018

Strengthening national vaccine decision-making: Assessing the impact of SIVAC Initiative support on national immunisation technical advisory group (NITAG) functionality in 77 low and middle-income countries.

Vaccine 2018 Dec 10. Epub 2018 Dec 10.

Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT London, United Kingdom; Modelling and Economics Unit, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address:

Background: National Immunisation Technical Advisory Groups (NITAGs) are multi-disciplinary expert groups that provide policy-makers with independent, evidence-based advice on vaccination. Between 2008 and 2017, the SIVAC Initiative supported establishment and strengthening of NITAGs in low and lower-middle income countries though its impact was never assessed quantitatively.

Aim: To quantitatively assess whether SIVAC support is associated with a faster rate at which NITAGs became functional based on six performance indicators. Read More

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December 2018

Exploring individual multiple sclerosis lesion volume change over time: Development of an algorithm for the analyses of longitudinal quantitative MRI measures.

Neuroimage Clin 2018 Dec 3. Epub 2018 Dec 3.

Dept. of Neuroradiology, University Hospital Carl Gustav Carus', Technische Universität Dresden, Dresden, SN, Germany.

Background: Magnetic resonance imaging (MRI) is used to follow-up multiple sclerosis (MS) and evaluate disease progression and therapy response via lesion quantification. However, there is a lack of automated post-processing techniques to quantify individual MS lesion change.

Objective: The present study developed a secondary post-processing algorithm for MS lesion segmentation routine to quantify individual changes in volume over time. Read More

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December 2018

Supporting general hospital staff to provide dementia sensitive care: A realist evaluation.

Int J Nurs Stud 2018 Nov 30. Epub 2018 Nov 30.

Centre for Research in Public Health and Community Care, University of Hertfordshire, College Lane, Hatfield, Hertfordshire, AL10 9AB, United Kingdom. Electronic address:

Background: There are an increasing number of interventions to improve hospital care for patients with dementia. Evidence for their impact on staff actions and patient outcomes is, however, limited and context dependent.

Objective: To explain the factors that support hospital staff to provide dementia sensitive care and with what outcomes for patients with dementia. Read More

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November 2018

Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations.

J Am Coll Cardiol 2018 Dec;72(24):3158-3176

Heidelberg University Hospital, Heidelberg, Germany; Department of Cardiology, McGill University Health Centre, Montreal, Canada; Department of Diagnostic Radiology, McGill University Health Centre, Montreal, Canada. Electronic address:

This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardial inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques. While each parameter may indicate myocardial inflammation, the authors propose that CMR provides strong evidence for myocardial inflammation, with increasing specificity, if the CMR scan demonstrates the combination of myocardial edema with other CMR markers of inflammatory myocardial injury. This is based on at least one T2-based criterion (global or regional increase of myocardial T2 relaxation time or an increased signal intensity in T2-weighted CMR images), with at least one T1-based criterion (increased myocardial T1, extracellular volume, or late gadolinium enhancement). Read More

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December 2018

Advancing pharmacological treatments for opioid use disorder (ADaPT-OUD): protocol for testing a novel strategy to improve implementation of medication-assisted treatment for veterans with opioid use disorders in low-performing facilities.

Addict Sci Clin Pract 2018 Dec 13;13(1):25. Epub 2018 Dec 13.

Center for Innovation to Implementation, Palo Alto Health Care System, 795 Willow Rd, MC152, Palo Alto, CA, 94304, USA.

Background: In the US, emergency room visits and overdoses related to prescription opioids have soared and the rates of illicit opioid use, including heroin and fentanyl, are increasing. Opioid use disorder (OUD) is associated with higher morbidity and mortality, higher HIV and HCV infection rates, and criminal behavior. Opioid agonist therapy (OAT; methadone and buprenorphine) is proven to be effective in treating OUD and decreasing its negative consequences. Read More

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December 2018

Measuring Relevant Information in Health Social Network Conversations and Clinical Diagnosis Cases.

Int J Environ Res Public Health 2018 Dec 9;15(12). Epub 2018 Dec 9.

Biomedical Informatics Group, Departamento de Lenguajes Sistemas Informáticos e Ingeniería de Software & Departamento de Inteligencia Artificial, Escuela Técnica Superior de Ingenieros Informáticos, Universidad Politécnica de Madrid, 28660 Madrid, Spain.

The Internet and social media is an enormous source of information. Health social networks and online collaborative environments enable users to create shared content that afterwards can be discussed. The aim of this paper is to present a novel methodology designed for quantifying relevant information provided by different participants in clinical online discussions. Read More

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December 2018

Spirituality but not Religiosity Is Associated with Better Health and Higher Life Satisfaction among Adolescents.

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

Department of Health Psychology, Faculty of Medicine, PJ Safarik University in Kosice, Trieda SNP 1, 04011 Kosice, Slovakia.

Careful conceptualization and differentiation of both spirituality and religiosity is a necessary precondition for understanding the potential role they play in health, whether physical or mental. The aim of this study was to explore the associations of spirituality with self-rated health, health complaints, and life satisfaction of adolescents with the moderating role of religiosity. Data from the Health Behaviour in School-aged Children study conducted in 2014 in Slovakia were used. Read More

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December 2018

Return-to-active-duty rates after anterior cervical spine surgery in military pilots.

Authors:

Neurosurg Focus 2018 Dec;45(6):E10

OBJECTIVESymptomatic cervical spondylosis with or without radiculopathy can ground an active-duty military pilot if left untreated. Surgically treated cervical spondylosis may be a waiverable condition and allow return to flying status, but a waiver is based on expert opinion and not on recent published data. Previous studies on rates of return to active duty status following anterior cervical spine surgery have not differentiated these rates among military specialty occupations. Read More

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December 2018

A real-time optimal inverse planning for Gamma Knife radiosurgery by convex optimization: description of the system and first dosimetry data.

Authors:

J Neurosurg 2018 Dec;129(Suppl1):111-117

OBJECTIVEThe authors developed a new, real-time interactive inverse planning approach, based on a fully convex framework, to be used for Gamma Knife radiosurgery.METHODSThe convex framework is based on the precomputation of a dictionary composed of the individual dose distributions of all possible shots, considering all their possible locations, sizes, and shapes inside the target volume. The convex problem is solved to determine the plan, i. Read More

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December 2018

Nintedanib in Idiopathic Pulmonary Fibrosis: Practical Management Recommendations for Potential Adverse Events.

Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.

Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More

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December 2018

Assisting BSN students in moving from novice to advanced beginner through student-LED simulations.

Nurse Educ Pract 2018 Dec 1;34:145-149. Epub 2018 Dec 1.

Northern Michigan University, School of Nursing, 2301 New Science Facility, 1401 Presque Isle Avenue, Marquette, MI, 49855, USA. Electronic address:

Faculty in a baccalaureate nursing (BSN) program recognized that fundamentals students often expressed a lack of confidence regarding translating knowledge and skills from long-term care environments into acute medical-surgical environments. This study used Benner's novice to expert framework as the basis for designing and implementing a peer-coached student led simulation with the aim of easing student transition from novice to advanced beginner. A mixed-methods descriptive design was used to gather and analyze qualitative data from peer-coach and learner focus groups. Read More

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December 2018

Distinguishing experts from novices by the Mind's Hand and Mind's Eye.

Cogn Psychol 2018 Dec 10;109:1-25. Epub 2018 Dec 10.

Cognitive Science Department, Rensselaer Polytechnic Institute, United States.

Tetris is a complex task notable for the increasingly substantial demands it makes on perception, decision-making, and action as the game is played. To investigate these issues, we collected data on 39 features of Tetris play for each Tetris zoid (piece), for up to 16 levels of difficulty, as each of 240 players played an hour of Tetris under laboratory conditions. Using only early (level 1) data, we conducted a Principle Component Analysis which found intriguing differences among its three, statistically significant, principle components. Read More

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December 2018

Quality indicators for ambulatory care for older adults with diabetes and comorbid conditions: A Delphi study.

PLoS One 2018 13;13(12):e0208888. Epub 2018 Dec 13.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

Background: An increasing number of people are living with multiple chronic conditions and it is unclear which quality indicators should be used to guide care for this population.

Objective: To critically appraise and select the most appropriate set of quality indicators for ambulatory care for older adults with five selected disease combinations.

Methods: A two-round web-based Delphi process was used to critically appraise and select quality of care indicators for older adults with diabetes and comorbidities. Read More

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December 2018

Using household survey data to identify large-scale food security patterns across Uganda.

PLoS One 2018 13;13(12):e0208714. Epub 2018 Dec 13.

International Livestock Research Institute, Sustainable Livestock Systems, Nairobi, Kenya.

To target food security interventions for smallholder households, decision makers need large-scale information, such as maps on poverty, food security and key livelihood activities. Such information is often based on expert knowledge or aggregated data, despite the fact that food security and poverty are driven largely by processes at the household level. At present, it is unclear if and how household level information can contribute to the spatial prediction of such welfare indicators or to what extent local variability is ignored by current mapping efforts. Read More

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December 2018

The ability of the ICD-AIS map to identify seriously injured patients in road traffic accidents-A study from Finland.

Traffic Inj Prev 2018 Dec 13:1-6. Epub 2018 Dec 13.

d Department of Orthopaedics and Traumatology , North Kymi Hospital , Kouvola , Finland.

Objective: In Finland, the severity of road traffic injuries is determined using the International Classification of Diseases, 10th Revision, Finnish Modification (ICD-10-FM) injury codes from Finnish Hospital Discharge data and the automatic conversion tool (ICD-AIS map) developed by the Association for the Advancement of Automotive Medicine (AAAM). The aim of this study was to evaluate the ability of the ICD-AIS map to identify seriously injured patients due to traffic accidents in Finnish injury data by comparing the severity rating generated by an expert and by the ICD-AIS map.

Methods: Our data came from the North Kymi Hospital (level 2 trauma center at the time of the study). Read More

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December 2018

Automated Neuron Reconstruction from 3D Fluorescence Microscopy Images Using Sequential Monte Carlo Estimation.

Neuroinformatics 2018 Dec 12. Epub 2018 Dec 12.

Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Microscopic images of neuronal cells provide essential structural information about the key constituents of the brain and form the basis of many neuroscientific studies. Computational analyses of the morphological properties of the captured neurons require first converting the structural information into digital tree-like reconstructions. Many dedicated computational methods and corresponding software tools have been and are continuously being developed with the aim to automate this step while achieving human-comparable reconstruction accuracy. Read More

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December 2018

Age and time course of long-term motor and nonmotor complications in Parkinson disease.

Neurology 2018 Dec 12. Epub 2018 Dec 12.

From Université Lyon (S.P., T.D., C.L., E.M., E.B., S.T.), Institut des Sciences Cognitives-Marc Jeannerod, CNRS, UMR 5229, Bron; Hospices Civils de Lyon (S.P., T.D., C.C., C.L., E.M., H.M., E.B., S.T.), Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson, Bron; Université Lyon (C.L., E.B., D.M.-B., S.T.), Faculté de Médecine Lyon Sud Charles Mérieux, Oullins; Hospices Civils de Lyon (D.M.-B.), Service de Biostatistique, Lyon; and Université Lyon (D.M.-B.), Laboratoire de Biométrie et Biologie Évolutive, CNRS, UMR 5558, Pierre Benite, France.

Objective: To determine the time course of hazard for motor and nonmotor milestones of Parkinson disease (PD) in the long term and to investigate whether risk scales nonlinearly with time is instrumental in identifying changes in pathological processes and evaluating disease-modifying therapies in PD.

Methods: Outpatients with PD at the Lyon University Movement Disorders Center were evaluated for 7 clinical milestones in this retrospective cohort study, encompassing 4 domains of PD progression: (1) motor (motor fluctuations, dyskinesias); (2) axial (postural instability and falls, freezing of gait); (3) neuropsychiatric (impulse control disorders, hallucinations); and (4) cognitive (dementia) complications. For each complication, we estimated the outcome-specific hazard using parsimonious smooth parametric Poisson regression models allowing for nonlinear scaling over disease duration, age at diagnosis, current age, and their interaction. Read More

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December 2018

Bringing harmony to public health debates about food.

Authors:
Jean Adams

BMJ 2018 Dec 12;363:k5028. Epub 2018 Dec 12.

Centre for Diet & Activity Research, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

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December 2018

Medical organisations must divest from fossil fuels.

BMJ 2018 Dec 12;363:k5163. Epub 2018 Dec 12.

Queen Mary University, London, UK

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December 2018

Review of titanium surface modification techniques and coatings for antibacterial applications.

Acta Biomater 2019 Jan 26;83:37-54. Epub 2018 Oct 26.

LBPS/CSPBAT, UMR CNRS 7244, Institut Galilée, Université Paris 13, Sorbonne Paris Cité, 99 Avenue JB Clément, 93340 Villetaneuse, France.

Implanted biomaterials play a key role in the current success of orthopedic and dental procedures. Pure titanium and its alloys are the most commonly used materials for permanent implants in contact with bone. However, implant-related infections remain among the leading reasons for failure. Read More

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January 2019

Assessment of unmet needs to address noncompliant households during polio supplemental immunization activities in Kaduna state, 2014-2016.

BMC Public Health 2018 Dec 13;18(Suppl 4):1309. Epub 2018 Dec 13.

World Health Organization Country Office, Abuja, Nigeria.

Background: Despite concerted global efforts being made to eradicate poliomyelitis, the wild poliovirus still circulates in three countries, including Nigeria. In addition, Nigeria experiences occasional outbreaks of the circulating vaccine-derived poliovirus type 2 (cVDPV2). Vaccine rejection by caregivers persists in some parts of northern Nigeria, which compromises the quality of supplemental immunization activities (SIAs). Read More

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December 2018

Towards an effective poliovirus laboratory containment strategy in Nigeria.

BMC Public Health 2018 Dec 13;18(Suppl 4):1304. Epub 2018 Dec 13.

World Health Organization, Country Representative Office, Abuja, Nigeria.

Background: The Global Commission for the Certification of the Eradication of Poliomyelitis will declare the world free of wild poliovirus transmission when no wild virus has been found in at least 3 consecutive years, and all laboratories possessing wild poliovirus materials have adopted appropriate measures of containment. Nigeria has made progress towards poliomyelitis eradication with the latest reported WPV type 1 on 21 Aug 2016 after 2 years without any case. This milestone achievement was followed by an inventory of biomedical laboratories completed in November 2015 with the destruction of all identified infectious materials. Read More

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December 2018

Test sensitivity of mammography and mean sojourn time over 40 years of breast cancer screening in Nijmegen (The Netherlands).

J Med Screen 2018 Dec 12:969141318814869. Epub 2018 Dec 12.

1 Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: We investigated whether changes in mammographic technique and screening policy have improved mammographic sensitivity, and elongated the mean sojourn time, since the introduction of biennial breast cancer screening in Nijmegen, the Netherlands, in 1975.

Methods: Maximum likelihood estimation, non-linear regression, and Markov Chain Monte Carlo simulation were used to estimate test sensitivity, mean sojourn time, and underlying breast cancer incidence in four time periods, covering 40 years of breast cancer screening in Nijmegen (1975-2012).

Results: Maximum likelihood estimation generated an estimated test sensitivity of approximately 90% and a mean sojourn time around three years, while the estimates based on non-linear regression and Markov Chain Monte Carlo simulation were 80% and four years, respectively. Read More

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December 2018

Observatoire Français de la Sclérose en Plaques (OFSEP): A unique multimodal nationwide MS registry in France.

Mult Scler 2018 Dec 13:1352458518815602. Epub 2018 Dec 13.

Department of Neurology, CHU de Toulouse, Toulouse, France.

The care of multiple sclerosis (MS) in France is based on two complementary interlinked networks: MS expert centers in university hospitals and regional networks of neurologists. The routine use of European database for multiple sclerosis (EDMUS) in all those centers has paved the way for the constitution of a national registry, designated as Observatoire Français de la Sclérose En Plaques (OFSEP). It promotes a prospective, standardized, high-quality, and multimodal collection of data. Read More

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December 2018

Mechanism of action of the trastuzumab biosimilar CT-P6.

Expert Opin Biol Ther 2018 Dec 13:1-11. Epub 2018 Dec 13.

a Biotechnology Research Institute, Celltrion Inc , Incheon , Republic of Korea.

Objectives: Therapeutic monoclonal antibody biosimilars are expected to help reduce the sizeable economic burden of targeted treatments. Trastuzumab (Herceptin®), a recombinant humanized monoclonal antibody that binds to the extracellular domain of HER2, is approved for use in HER2-overexpressing breast cancer (in both the adjuvant and metastatic settings) and HER2-positive gastric cancer. CT-P6 (Herzuma®) is a biosimilar of trastuzumab, designed to bind with high affinity and specificity to the same HER2 epitope as the reference product. Read More

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December 2018

The psychometric evaluation of the Turkish version of the Mann Assessment of Swallowing Ability in patients in the early period after stroke

Turk J Med Sci 2018 12 12;48(6):1153-1161. Epub 2018 Dec 12.

Physical Medicine and Rehabilitation Clinic, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

Background/aim: The Mann Assessment of Swallowing Ability (MASA) is an efficient tool that allows physicians to determine the alertness, cooperation, and respiration of patients, which are important factors when assessing swallowing . This study aimed to translate the MASA into Turkish (T-MASA) and to assess its reliability and validity in patients during the early period after a stroke .

Materials And Methods: The scale was administered to 141 patients in the early period after a stroke. Read More

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December 2018

User involvement in regulation: A qualitative study of service user involvement in Care Quality Commission inspections of health and social care providers in England.

Health Expect 2018 Dec 7. Epub 2018 Dec 7.

The King's Fund, London, UK.

Background: High profile failures of care in the NHS have raised concerns about regulatory systems for health-care professionals and organizations. In response, the Care Quality Commission (CQC), the regulator of health and social care in England overhauled its regulatory regime. It moved to inspections which made much greater use of expert knowledge, data and views from a range of stakeholders, including service users. Read More

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December 2018

Epigenetic inhibitors for the precision treatment of -mutant ovarian cancers: what are the next steps?

Expert Rev Precis Med Drug Dev 2018 25;3(4):233-236. Epub 2018 Jul 25.

Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Research Complex-2; MS8613, 12700 East 19th Avenue, Aurora, Colorado 80045.

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The interrater reliability of static palpation of the thoracic spine for eliciting tenderness and stiffness to test for a manipulable lesion.

Chiropr Man Therap 2018 4;26:49. Epub 2018 Dec 4.

1School of Health Professions, Murdoch University, 90 South Street, Murdoch, WA 6150 Australia.

Background: Despite widespread use by manual therapists, there is little evidence regarding the reliability of thoracic spine static palpation to test for a manipulable lesion using stiffness or tenderness as diagnostic markers. We aimed to determine the interrater agreement of thoracic spine static palpation for segmental tenderness and stiffness and determine the effect of standardised training for examiners. The secondary aim was to explore expert consensus on the level of segmental tenderness required to locate a "manipulable lesion". Read More

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December 2018

Classification Videos Reveal the Visual Information Driving Complex Real-World Speeded Decisions.

Front Psychol 2018 20;9:2229. Epub 2018 Nov 20.

Department of Psychology, City, University of London, London, United Kingdom.

Humans can rapidly discriminate complex scenarios as they unfold in real time, for example during law enforcement or, more prosaically, driving and sport. Such decision-making improves with experience, as new sources of information are exploited. For example, sports experts are able to predict the outcome of their opponent's next action (e. Read More

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November 2018

Nurses' experiences of caring for patients with intellectual developmental disorders: a systematic review using a meta-ethnographic approach.

BMC Nurs 2018 3;17:51. Epub 2018 Dec 3.

1Department of Care Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden.

Background: Research suggests that registered nurses (RNs) do not feel adequately prepared to support patients with intellectual disability disorder (IDD). This is unsurprising, as few European health sciences curricula include undergraduate and graduate training courses in IDD. As RNs are often in the front line of care, eliciting in-depth knowledge about how they experience nursing this group of patients is vital. Read More

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December 2018

Uncertainties associated with assessing Ontario uranium miners' exposure to radon daughters.

J Radiol Prot 2018 Nov 19. Epub 2018 Nov 19.

Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, CANADA.

The Ontario uranium miners study is a large (n=28 546) cohort with low levels of radon exposure relative to other miner cohorts. Multiple methods were used over time to estimate annual occupational exposure to radon daughters including: mine-specific extrapolations by mining engineers, area sampling in limited areas of the mines combined with approximate working time and lastly, consistent exposure sampling in different locations of the mine combined with workers' time cards. Nonetheless, estimating exposures involves assumptions that lead to some uncertainty in occupational exposure characterization arising from the assessment approach and variability within workplace, over time and by individual. Read More

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November 2018

Deep learning in the cross-time-frequency domain for sleep staging from a single lead electrocardiogram.

Physiol Meas 2018 Nov 23. Epub 2018 Nov 23.

Department of Biomedical Informatics, Emory University, 36 Eagle Row, #571, MS 2045-001-1AC, Atlanta, GA 30322, Atlanta, Georgia, UNITED STATES.

Objective: This study classifies sleep stages from a single lead electrocardiogram (ECG) using beat detection, cardiorespiratory coupling in the time-frequency domain and a deep convolutional neural network (CNN). Approach: An ECG-derived respiration (EDR) signal and synchronous beat-to-beat heart rate variability (HRV) time series were derived from the ECG using previously described robust algorithms. A measure of cardiorespiratory coupling (CRC) was extracted by calculating the coherence and cross-spectrogram of the EDR and HRV signal in five-minute windows. Read More

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November 2018

[E-Learning in bachelor-level nursing education in Germany and the role of the nurse educator - a Delphi survey].

Pflege 2018 Dec 7:1-16. Epub 2018 Dec 7.

3 Institut für Gesundheits- und Pflegewissenschaften, Hochschule Esslingen.

E-Learning in bachelor-level nursing education in Germany and the role of the nurse educator - a Delphi survey Abstract.

Background: In addition to conventional face-to-face classes, e-learning is becoming more prevalent in tertiary-level nurse education. Its asynchronous, decentralized nature influences teaching and learning. Read More

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December 2018

Proteomic insights into lysine acetylation and the implications for medical research.

Expert Rev Proteomics 2018 Dec 7. Epub 2018 Dec 7.

a Laboratorio de Proteómica, Centro de Ciencias Genómicas , Universidad Nacional Autónoma de México , Cuernavaca , Morelos C. P. 62210, México .

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December 2018

Managing pulmonary complications in allogeneic hematopoietic stem cell transplantation.

Expert Rev Respir Med 2018 Dec 7. Epub 2018 Dec 7.

a Service de Pneumologie , AP-HP, Hôpital Saint-Louis , F-75010 , Paris , France.

Introduction: Progress in allogeneic hematopoietic stem cell transplantation (HSCT) procedures have been associated with improved survival in HSCT recipients. However, they have also brought to light organ-specific complications, especially pulmonary complications. In this setting, pulmonary complications are consistently associated with poor outcomes, and improved management of these complications is required. Read More

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December 2018

From the laboratory concept to clinical trials: the journey of Otoimplant so far.

Expert Rev Med Devices 2018 Dec 7. Epub 2018 Dec 7.

a AGH University of Science and Technology , Faculty of Materials Science and Ceramics, Department of Ceramics and Refractories , al. A. Mickiewicza 30, 30-059 Krakow , Poland.

Introduction: Nowadays, the role of alloplastic prostheses has become more important in ossicular chain reconstruction. Especially, bioactive medical devices may be an alternative for those currently used on the market. Areas covered: Medical devices which are implanted for over 30 days in the body are required to fulfil strict requirements. Read More

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December 2018

Letter to the editor: Efficacy and safety of a combination of HER2-targeted agents as first-line treatment for metastatic HER2-positive breast cancer: a network meta-analysis.

Expert Opin Drug Saf 2018 Dec 7. Epub 2018 Dec 7.

a Department of Oncology , Weifang Traditional Chinese hospital , Weifang , Shandong , China.

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December 2018

Lamotrigine as a mood stabilizer: insights from the pre-clinical evidence.

Expert Opin Drug Discov 2018 Dec 7:1-12. Epub 2018 Dec 7.

a Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina , Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

Introduction: Lamotrigine (LTG) is a well-established anticonvulsant that is also approved for the prevention of mood relapses in bipolar disorder. However, the mechanisms underlying LTG mood stabilizing effects remain unclear. Areas covered: Herein, the pre-clinical evidence concerning LTG's' mode of action in depression and mania is reviewed. Read More

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December 2018

Valuation of EQ-5D-5L health states: a comparison of seven Asian populations.

Expert Rev Pharmacoecon Outcomes Res 2018 Dec 7. Epub 2018 Dec 7.

n National University of Singapore , Singapore , Singapore.

Objectives: To compare the time trade-off (TTO) utility values of EQ-5D-5L health states elicited from different general populations in Asia.

Methods: We analyzed the TTO data from seven Asian EQ-5D-5L valuation studies in which utility values of 86 EQ-5D-5L health states were elicited from general population samples. An eight-parameter multiplicative regression model including five dimension parameters (mobility [MO], self-care, usual activities [UA], pain/discomfort, anxiety/depression) and three level parameters (level 2 [L2], level 3 [L3], and level 4 [L4]) was used to model the data from each of the populations. Read More

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December 2018

New drugs in preclinical and early stage clinical development in the treatment of heart failure.

Expert Opin Investig Drugs 2018 Dec 7:1-21. Epub 2018 Dec 7.

a Department of Pharmacology and Toxicology, School of Medicine , Universidad Complutense, CIBERCV , Madrid , Spain.

Introduction: Heart failure (HF) represents a major health problem because of its high prevalence, high rates of hospitalizations, and mortality and significant healthcare costs. HF comprises a heterogeneous group of syndromes with different pathophysiology, clinical presentations, and response to therapy. Basic research has identified multiple putative therapeutic targets involved in the pathogenesis of HF and many promising drugs are under development. Read More

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December 2018