898 results match your criteria Expert Review of Obstetrics & Gynecology [Journal]


Towards a universal concept of vulnerability: Broadening the evidence from the elderly to perinatal health using a Delphi approach.

PLoS One 2019 20;14(2):e0212633. Epub 2019 Feb 20.

Public Health, Environmental and Social Determinants of Health Department (PHE), World Health Organization, Geneva, Switzerland.

Background: The concept 'vulnerability' is prevalent in the public domain, health care, social institutions and multidisciplinary research. Conceptual heterogeneity is present, hampering the creation of a common evidence-base of research achievements and successful policies. Recently an international expert group combined a specific literature review with a 2-stage Delphi procedure, arriving at a seemingly universal concept of vulnerability for the elderly with applications for research instruments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212633PLOS
February 2019

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper.

Crit Rev Oncol Hematol 2019 Feb 19;134:39-45. Epub 2018 Dec 19.

Department of Tumor Biology, Center of Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The heterogeneity of metastatic breast cancer (MBC) necessitates novel biomarkers allowing stratification of patients for treatment selection and drug development. We propose to use the prognostic utility of circulating tumor cells (CTCs) for stratification of patients with stage IV disease.

Methods: In a retrospective, pooled analysis of individual patient data from 18 cohorts, including 2436 MBC patients, a CTC threshold of 5 cells per 7. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.12.004DOI Listing
February 2019
1 Read

Management of fetal tumors.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 14. Epub 2019 Jan 14.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada. Electronic address:

In this review article, we discuss the most common fetal tumors, their prenatal management, and outcomes. Overall, the most important outcome predictors are tumor histology, size, vascularity, and location. Very large lesions, lesions causing cardiac failure, and hydrops and lesions obstructing the fetal airway have the poorest outcome, as they may cause fetal death or complications at the time of delivery. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.006DOI Listing
January 2019
2 Reads

A comprehensive review of hormonal and biological therapies for endometriosis: latest developments.

Expert Opin Biol Ther 2019 Feb 14. Epub 2019 Feb 14.

a Academic Unit of Obstetrics and Gynecology , Ospedale Policlinico San Martino , Largo R. Benzi 10, 16132 Genoa , Italy.

Introduction: Endometriosis is a chronic benign estrogen dependent disease characterized by the presence of endometriotic glands and stroma outside the uterine cavity. Although combined hormonal contraceptives and progestins, currently available first-line treatments for endometriosis, are efficacious and well tolerated for treating disease-related pain, some women experience partial or no improvement of pain or its recurrence is frequent after discontinuation of the therapies. For these reasons, new drugs are under investigation for the treatment of endometriosis. Read More

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http://dx.doi.org/10.1080/14712598.2019.1581761DOI Listing
February 2019
1 Read

Depression during perimenopause: the role of the obstetrician-gynecologist.

Arch Womens Ment Health 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 NE Pacific St., Box 356460, Seattle, WA, 98195-6460, USA.

Depression in women is more common during perimenopause (the transition to menopause) than at other times in the life cycle. Symptoms of depression may be different in perimenopausal women compared to younger or older women, and are often dismissed as part of normal menopause. This is an expert narrative review. Read More

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http://link.springer.com/10.1007/s00737-019-0950-6
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http://dx.doi.org/10.1007/s00737-019-0950-6DOI Listing
February 2019
2 Reads

Monitoring quality of obstetric care from hospital discharge databases: A Delphi survey to propose a new set of indicators based on maternal health outcomes.

PLoS One 2019 12;14(2):e0211955. Epub 2019 Feb 12.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé) Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France.

Objectives: Most indicators proposed for assessing quality of care in obstetrics are process indicators and do not directly measure health effects, and cannot always be identified from routinely available databases. Our objective was to propose a set of indicators to assess the quality of hospital obstetric care from maternal morbidity outcomes identifiable in permanent hospital discharge databases.

Methods: Various maternal morbidity outcomes potentially reflecting quality of obstetric care were first selected from a systematic literature review. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211955PLOS
February 2019
2 Reads

Current state of the art and emerging pharmacotherapy for uterine leiomyosarcomas.

Expert Opin Pharmacother 2019 Feb 6:1-11. Epub 2019 Feb 6.

a Academic Unit of Obstetrics and Gynecology , IRCCS Ospedale Policlinico San Martino , Genoa , Italy.

Introduction: Uterine leiomyosarcomas (ULMS) account for 1% of all uterine malignancies and for 30% of all uterine sarcomas. The preoperative diagnosis of ULMS is challenging for the physicians, as the symptoms of these tumors are often vague and nonspecific. Moreover, as ULMS have an aggressive biologic behavior, affected women frequently have very poor prognosis. Read More

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http://dx.doi.org/10.1080/14656566.2019.1571042DOI Listing
February 2019
4 Reads
3.534 Impact Factor

Current and emerging pharmacotherapy for emergency management of preeclampsia.

Expert Opin Pharmacother 2019 Feb 1:1-12. Epub 2019 Feb 1.

a Ritchie Centre, Department of Obstetrics and GynaecologySchool of Clinical Sciences , Monash University , Clayton , Australia.

Introduction: Preeclampsia is a disease specific to pregnancy characterised by new onset hypertension with maternal organ dysfunction and/or fetal growth restriction. It remains a major cause of maternal and perinatal morbidity and mortality. For fifty years, antihypertensives have been the mainstay of treating preeclampsia, reducing maternal morbidity and mortality. Read More

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http://dx.doi.org/10.1080/14656566.2019.1570134DOI Listing
February 2019
2 Reads

Endometrial cancer and bariatric surgery: A scoping review.

Surg Obes Relat Dis 2018 Dec 6. Epub 2018 Dec 6.

Cross Cancer Institute, Department of Obstetrics & Gynecology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Background: Endometrial cancer is strongly associated with obesity, and weight reduction has been demonstrated to decrease risk and overall mortality. Bariatric surgery results in the most dramatic weight loss among morbidly obese individuals, and the impact of bariatric surgery on endometrial cancer requires further investigation.

Objective: To conduct a scoping review of the published literature of the effects of bariatric surgery on endometrial cancer, as risk reduction and potential adjunct to treatment. Read More

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http://dx.doi.org/10.1016/j.soard.2018.12.003DOI Listing
December 2018

The energy based devices for vaginal "rejuvenation," urinary incontinence, vaginal cosmetic procedures, and other vulvo-vaginal disorders: An international multidisciplinary expert panel opinion.

Neurourol Urodyn 2019 Jan 29. Epub 2019 Jan 29.

Ain Shams University, Department of Urology, Cairo, Egypt.

Aims: Energy-based devices using radiofrequency and laser technologies have gained popularity as therapies for vaginal atrophy, urinary incontinence, and vaginal prolapse. They have been promoted by cosmetic and aesthetic industries for vaginal "laxity" and vaginal "rejuvenation," both of which are undefined conditions and terms. This article aims to review the current available literature and its quality on this emerging technology. Read More

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http://dx.doi.org/10.1002/nau.23927DOI Listing
January 2019
1 Read

Oral investigational drugs currently in phase I or phase II for the amelioration of menopausal symptoms.

Expert Opin Investig Drugs 2019 Mar 1;28(3):235-247. Epub 2019 Feb 1.

b Department of Obstetrics and Gynecology , University of Liège , Liège , Belgium.

Introduction: Menopausal symptoms have a substantial effect on the quality of life of many women; hence, investigations for the amelioration of menopausal symptoms continue to be necessary. The two main approaches to the amelioration of symptoms are hormone therapy (HT) and non-hormonal therapy. Areas covered: This review provides a background for understanding the types of menopausal symptoms and their underlying physiology. Read More

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http://dx.doi.org/10.1080/13543784.2019.1572114DOI Listing
March 2019
1 Read

The importance of pre- and post-test counseling for prenatal cell-free DNA screening for common fetal aneuploidies.

Expert Rev Mol Diagn 2019 Jan 18:1-15. Epub 2019 Jan 18.

a Department of Obstetrics and Gynecology , Fetomaternal Medical Center, Helsinki University and Helsinki University Hospital , Helsinki , Finland.

Introduction: Prenatal cell-free DNA screening for common fetal aneuploidies has rapidly changed the paradigm of prenatal care. Despite its advantages compared to conventional screening methods, its unexpectedly rapid implementation in clinical practice has generated several ethical and medical issues and misconceptions. Aggressive commercial marketing of cell-free DNA screening and media dissemination of misleading information have added confusion. Read More

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http://dx.doi.org/10.1080/14737159.2019.1571912DOI Listing
January 2019
2 Reads

The New York State Safe Motherhood Initiative: Early Impact of Obstetric Hemorrhage Bundle Implementation.

Am J Perinatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Objective:  To determine the effects of the Safe Motherhood Initiative's (SMI) obstetric hemorrhage bundle in New York State (NYS).

Methods:  In 2013, the SMI convened interprofessional workgroups on hemorrhage, venous thromboembolism, and hypertension tasked with developing evidence-based care bundles. Participating hospitals submitted data measured before, during, and after implementation of the hemorrhage bundle: maternal mortality, intensive care unit (ICU) admission, cardiovascular collapse, hysterectomy, and transfusion of ≥4 units of red blood cells (RBCs). Read More

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http://dx.doi.org/10.1055/s-0038-1676976DOI Listing
January 2019
2 Reads

Outcome of first trimester medical termination of pregnancy: definitions and management.

Eur J Contracept Reprod Health Care 2018 Dec 2;23(6):451-457. Epub 2019 Jan 2.

b Department of Women's and Children's Health, Division of Obstetrics and Gynaecology , Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden.

Objective: Medical termination of pregnancy (MToP, or medical abortion) is a highly effective method with a reported efficacy of 95-98%. However, different criteria are currently used to define success, and there are different recommendations for the treatment of what is considered a failure of MToP. This work was undertaken to develop a consensus around a set of well-defined MToP outcomes, as recommended by the Core Outcomes in Women's and Newborn Health initiative. Read More

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http://dx.doi.org/10.1080/13625187.2018.1535058DOI Listing
December 2018
2 Reads

Physicians' attitudes and views regarding religious fasting during pregnancy and review of the literature.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 17;233:76-80. Epub 2018 Dec 17.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

Many patients worldwide seek medical advice regarding safety of fasting during pregnancy. This issue lacks high quality evidence, which makes giving medical advice challenging. To aid decision making on this subject we performed an internet mediated survey to determine the expert opinion on this issue. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.015DOI Listing
February 2019
4 Reads

Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer.

Expert Opin Investig Drugs 2019 Feb 21;28(2):131-142. Epub 2018 Dec 21.

a Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) , University of Genova , Italy.

Introduction: Endometrial cancer (EC) is the most common neoplasm of the female genital tract in developed countries. Despite the progress in early detection and treatment, a significant number of cases of advanced ECs are still diagnosed. These patients have few treatment options and a poor prognosis. Read More

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http://dx.doi.org/10.1080/13543784.2018.1558202DOI Listing
February 2019
2 Reads
5.528 Impact Factor

From mother to baby: antenatal exposure to monoclonal antibody biologics.

Expert Rev Clin Immunol 2019 Mar 24;15(3):221-229. Epub 2019 Jan 24.

i Departments of Pediatrics and Community Health & Epidemiology , Dalhousie University , Halifax , NS , Canada.

Introduction: More women with autoimmune and inflammatory conditions are being treated with monoclonal antibody biologics (mAbs) during their pregnancy, to maintain clinical remission. The use of anti-tumor necrosis factor alpha agents in pregnancy appears to be safe but less is known regarding other mAbs, such as anti-integrins and anti-cytokine agents. There are currently no comprehensive guidelines on how to manage the exposed infants. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1561282DOI Listing
March 2019
14 Reads

Role of Mental Health Practitioner in Infertility Clinics: A Review on Past, Present and Future Directions.

J Hum Reprod Sci 2018 Jul-Sep;11(3):219-228

Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal, Karnataka, India.

A large body of literature has emerged over the past four decades which highlights the need to address emotional needs in infertility and integrates psychological services within routine fertility care. Evidenced-based guidelines in most countries propagate that the mental health expert (MHP) plays a vital role as a team member in reducing the impact of infertility on the lives of patients, across all stages of treatment. In accordance with these global developments, inclusion of psychosocial care in fertility treatments is an upcoming trend in our nation. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_41_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262662PMC
December 2018
1 Read

Epigenetic inhibitors for the precision treatment of -mutant ovarian cancers: what are the next steps?

Expert Rev Precis Med Drug Dev 2018 25;3(4):233-236. Epub 2018 Jul 25.

Department of Obstetrics & Gynecology, University of Colorado Anschutz Medical Campus, Research Complex-2; MS8613, 12700 East 19th Avenue, Aurora, Colorado 80045.

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http://dx.doi.org/10.1080/23808993.2018.1503050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277026PMC
July 2018
1 Read

Creation of an Enhanced Recovery After Surgery (ERAS) Guideline for neonatal intestinal surgery patients: a knowledge synthesis and consensus generation approach and protocol study.

BMJ Open 2018 Dec 9;8(12):e023651. Epub 2018 Dec 9.

Department of Surgery, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Introduction: Enhanced Recovery After Surgery (ERAS) guidelines integrate evidence-based practices into multimodal care pathways designed to optimise patient recovery following surgery. The objective of this project is to create an ERAS protocol for neonatal abdominal surgery. The protocol will identify and attempt to bridge the gaps between current practices and best evidence. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303622PMC
December 2018
2 Reads
2.063 Impact Factor

Deep-learned placental vessel segmentation for intraoperative video enhancement in fetoscopic surgery.

Int J Comput Assist Radiol Surg 2019 Feb 27;14(2):227-235. Epub 2018 Nov 27.

Yale University School of Medicine, New Haven, USA.

Introduction: Twin-to-twin transfusion syndrome (TTTS) is a potentially lethal condition that affects pregnancies in which twins share a single placenta. The definitive treatment for TTTS is fetoscopic laser photocoagulation, a procedure in which placental blood vessels are selectively cauterized. Challenges in this procedure include difficulty in quickly identifying placental blood vessels due to the many artifacts in the endoscopic video that the surgeon uses for navigation. Read More

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http://link.springer.com/10.1007/s11548-018-1886-4
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http://dx.doi.org/10.1007/s11548-018-1886-4DOI Listing
February 2019
3 Reads

Preventing complications by persistence with iron replacement therapy: a comprehensive literature review.

Curr Med Res Opin 2018 Nov 26:1-18. Epub 2018 Nov 26.

b Department of Women , Child, and General and Specialist Surgery, University of Campania Luigi Vanvitelli , Naples , Italy.

Objective: Iron deficiency and particularly iron deficiency anemia (IDA) can lead to negative health consequences. This review describes the importance of adherence and persistence (adhering to treatment for the recommended duration) with iron replacement therapy in the prevention of complications, particularly regarding its recommended dosing schedule.

Methods: Comprehensive literature searches were performed of Medline and the Cochrane library from 2000-2018. Read More

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https://www.tandfonline.com/doi/full/10.1080/03007995.2018.1
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http://dx.doi.org/10.1080/03007995.2018.1552850DOI Listing
November 2018
12 Reads

Atezolizumab for the treatment of triple-negative breast cancer.

Expert Opin Investig Drugs 2019 Jan 1;28(1):1-5. Epub 2018 Dec 1.

a Department of Obstetrics and Gynecology, Division of Molecular Oncology , University Medical Center , Mainz , Germany.

Introduction: Triple-negative breast cancer (TNBC) is associated with poor prognosis and limited treatment options. However, TNBC is known to be more immunogenic compared to other breast cancer subtypes, with tumor-infiltrating lymphocytes playing an important prognostic and predictive role. Furthermore, TNBC has a higher level of programmed cell death-ligand 1 (PD-L1) expression. Read More

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https://www.tandfonline.com/doi/full/10.1080/13543784.2019.1
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http://dx.doi.org/10.1080/13543784.2019.1552255DOI Listing
January 2019
11 Reads

How safe is rucaparib in ovarian cancer?

Expert Opin Drug Saf 2018 Nov 19. Epub 2018 Nov 19.

a Department of Obstetrics and Gynecology , The Ohio State University Wexner Medical Center , Columbus.

Introduction: Rucaparib is increasingly being utilized for women with recurrent ovarian cancer both as treatment and maintenance therapy. PARP inhibitors like rucaparib are daily oral medication that exploit the DNA repair pathway. The most significant clinical benefit is in those tumors exhibiting deficiency in their homologous recombination pathway. Read More

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http://dx.doi.org/10.1080/14740338.2018.1550067DOI Listing
November 2018
30 Reads

Links between HPA axis and adipokines: clinical implications in paradigms of stress-related disorders.

Expert Rev Endocrinol Metab 2018 Nov 13;13(6):317-332. Epub 2018 Nov 13.

a Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, School of Medicine , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated by hormones of the HPA axis such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids (GCs) and adipokines secreted by the adipose tissue. Areas covered: In this critical review, the bi-directional interactions between HPA axis and the most studied adipokines such as leptin and adiponectin, as well as the pro-inflammatory adipocytokines tumor necrosis factor (TNF) and interleukin (IL) 6 are presented. Read More

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https://www.tandfonline.com/doi/full/10.1080/17446651.2018.1
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http://dx.doi.org/10.1080/17446651.2018.1543585DOI Listing
November 2018
11 Reads

Use of synthetic and biologic DMARDs during pregnancy.

Expert Rev Clin Immunol 2018 Oct 26:1-13. Epub 2018 Oct 26.

e Global Medical Expert , GlaxoSmithKline (GSK) , Upper Providence , PA , USA.

Introduction: Since most of the autoimmune diseases (AID) affect mostly women in their fertile years, and fertility is in general preserved, the use of disease-modifying antirheumatic drugs (DMARDs) during conception, pregnancy, and lactation has been a matter of concern in the treatment of women affected by AID. Areas covered: We performed a comprehensive review of the latest and most relevant research papers published in the field and discussed different aspects related to the use of synthetic and biologic DMARDs and immunosuppressants in the preconceptional period, during pregnancy and lactation in AID patients, both in males and females. Expert commentary: Active AID impose an increased risk for adverse maternal and fetal outcomes, such as preeclampsia, miscarriage, intrauterine growth restriction, prematurity, low birth weight, and stillbirth. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1541739DOI Listing
October 2018
25 Reads

Audit of transvaginal sonography of normal postmenopausal ovaries by sonographers from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

F1000Res 2018 10;7:1241. Epub 2018 Aug 10.

Gynaecological Oncology, UCL EGA Institute of Women's Health, London, WC1E 6BT, UK.

We report on a unique audit of seven sonographers self-reporting high visualization rates of normal postmenopausal ovaries in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). This audit was ordered by the trial's Ultrasound Management Subcommittee after an initiative taken in 2008 to improve the quality of scanning and the subsequent increase in the number of sonographers claiming very high ovary visualisation rates. Seven sonographers reporting high rates (>89%) of visualizing normal postmenopausal ovaries in examinations performed between 1 January and 31 December 2008 were identified. Read More

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https://f1000research.com/articles/7-1241/v1
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http://dx.doi.org/10.12688/f1000research.15663.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173132PMC
August 2018
2 Reads

Antibiotic therapy for pelvic inflammatory disease: an abridged version of a Cochrane systematic review and meta-analysis of randomised controlled trials.

Sex Transm Infect 2019 Feb 19;95(1):21-27. Epub 2018 Oct 19.

Whittall Street Clinic, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

Objective: To assess the effectiveness and safety of antibiotic regimens used to treat pelvic inflammatory disease (PID).

Design: This is a systematic review and meta-analysis of randomised controlled trials (RCTs). Risk of bias was assessed using the criteria outlined in the Cochrane guidelines. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053693DOI Listing
February 2019
3 Reads

Squamous cell carcinoma of the vulva: a review of present management and future considerations.

Expert Rev Anticancer Ther 2019 Jan 26;19(1):43-50. Epub 2018 Oct 26.

a Department of Obstetrics and Gynecology, Division of Gynecologic Oncology , Washington University School of Medicine, Alvin J. Siteman Cancer Center , St. Louis , MO , USA.

Introduction: Although a relatively uncommon disease, the treatment of vulvar cancer has changed considerably over the years and has been under considerable focus due to its past overtreatment and apparent increase in incidence. The purpose of this review is to describe the recommended management of the most commonly encountered vulvar carcinomas based on the most recent available literature. Areas covered: The clinical environment of squamous cell vulvar cancers are illustrated in order to describe the potential pitfalls and limitations of treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737140.2019.1
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http://dx.doi.org/10.1080/14737140.2019.1538797DOI Listing
January 2019
9 Reads

Pharmacodynamics of combined estrogen-progestin oral contraceptives 3. Inhibition of ovulation.

Expert Rev Clin Pharmacol 2018 Nov 6;11(11):1085-1098. Epub 2018 Nov 6.

a Department of Gynecology, Obstetrics and Urology, Sapienza , University of Rome , Rome , Italy.

Introduction: Following a historical overview, the ovulation-inhibiting effect of various orally administered estrogen-progestin combinations (combined oral contraceptives [COCs]) are examined for their components alone or in the various combined formulations. Special emphasis is given to products containing natural estrogens. Areas covered: Inhibition of ovulation with progestins alone; estrogens alone; various progestins in combination with ethinyl estradiol; various progestins in combination with natural estrogens (estradiol, estradiol valerate, and estetrol). Read More

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https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1
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http://dx.doi.org/10.1080/17512433.2018.1536544DOI Listing
November 2018
12 Reads

Management of gynecological cancer in pregnant patients.

Minerva Ginecol 2018 Oct 11. Epub 2018 Oct 11.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA -

Introduction: Cancer during pregnancy is a rare but challenging condition. More women delay childbearing and consequently the incidence of cancer during pregnancy is constantly increasing.

Evidence Acquisition: An extensive electronic search was performed in PubMed and Scopus. Read More

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https://www.minervamedica.it/index2.php?show=R09Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4784.18.04324-1DOI Listing
October 2018
9 Reads

Cross-Cultural Adaptation of the Cardiff Fertility Knowledge Scale and the Fertility Status Awareness Tool for the French-Canadian Population.

J Obstet Gynaecol Can 2019 Feb 10;41(2):204-209. Epub 2018 Oct 10.

Department of Human Kinetics, Université du Québec à Trois-Rivières, Trois-Rivières, QC. Electronic address:

Objective: The Cardiff Fertility Knowledge Scale (CFKS) and the Fertility Status Awareness Tool (FertiSTAT) are validated tools allowing the evaluation of fertility knowledge and raising awareness about risk indicators for reduced fertility. Their use by health care professionals practicing in the field of reproductive health might optimize fertility of the Canadian population. However, there currently is no version of these questionnaires for the French-Canadian population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163183027
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http://dx.doi.org/10.1016/j.jogc.2018.04.002DOI Listing
February 2019
17 Reads

Best Practices in North American Pre-Clinical Medical Education in Sexual History Taking: Consensus From the Summits in Medical Education in Sexual Health.

J Sex Med 2018 Oct;15(10):1414-1425

Department of Medicine, Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.

Introduction: This article discusses a blueprint for a sexual health communication curriculum to facilitate undergraduate medical student acquisition of sexual history taking skills and includes recommendations for important elements of a thorough sexual history script for undergraduate medical students.

Aim: To outline the fundamentals, objectives, content, timing, and teaching methods of a gold standard curriculum in sexual health communication.

Methods: Consensus expert opinion was documented at the 2012, 2014, and 2016 Summits in Medical Education in Sexual Health. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.08.008DOI Listing
October 2018
7 Reads

Advances in contraceptive vaginal rings: what does the future hold?

Expert Opin Pharmacother 2018 Oct 5;19(15):1685-1691. Epub 2018 Oct 5.

a Family Planning clinic, Department of Obstetrics and Gynecology , Federal University of Medical School , São Paulo, Campinas , Brazil.

Introduction: Contraceptive vaginal rings (CVRs) are good contraceptive options because they do not require skilled providers, are self-administered, and show a higher stability of drug diffusion. Area covered: This article provides a review of the developments made with CVRs over the past number of years, while giving focus to the latest CVRs that have gone through clinical development. The author of the article also provides an expert perspective on the future of these useful therapeutic options. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1519549DOI Listing
October 2018
2 Reads

The safety of bevazicumab for the treatment of ovarian cancer.

Expert Opin Drug Saf 2018 Nov 10;17(11):1107-1113. Epub 2018 Oct 10.

b Department of Clinical and Experimental Medicine , Gynecologic and Obstetrics Unit, University of Sassari , Sassari , Italy.

Introduction: The safety profile of bevacizumab (BV) remains a challenging issue, in particular its role in fragile OC patients. Areas covered: In this literature review, we have analyzed safety data from Phase III trials evaluating the combination of BV plus standard chemotherapy in advanced or recurrent OC patients. In particular, our review aimed at clarifying the impact of the drug on fragile patients, and the correlation between BV and postoperative complications after cytoreductive surgery. Read More

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http://dx.doi.org/10.1080/14740338.2018.1532500DOI Listing
November 2018
2 Reads

The association between early life antibiotic use and allergic disease in young children: recent insights and their implications.

Expert Rev Clin Immunol 2018 10 29;14(10):841-855. Epub 2018 Sep 29.

a School of Public Health , University of Alberta , Edmonton , Canada.

Introduction: Greater prescribing of antibiotics to infants has coincided with an epidemic of allergic disease. Through meta-analytic synthesis, accumulating evidence from prospective or database cohorts suggests a link between infant antibiotic treatment and the development of atopy. Stronger associations seen with multiple course and broad-spectrum antibiotic treatment add to biological plausibility. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1521271DOI Listing
October 2018
2 Reads

Successful weight loss interventions before in vitro fertilization: fat chance?

Fertil Steril 2018 09;110(4):581-586

Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Most expert opinions and guidelines indicate the necessity for weight loss before in vitro fertilization (IVF) in women who are overweight or obese. This is based on the documented impact of obesity on pregnancy rates and pregnancy complications and the long-term impact on the child in natural conceptions. Some clinicians and authorities refuse to treat patients unless they are below a certain body mass index. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.05.029DOI Listing
September 2018
2 Reads

Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations.

J Womens Health (Larchmt) 2019 Feb 5;28(2):117-134. Epub 2018 Sep 5.

11 Department of Psychiatry, Queen's University School of Medicine, Ontario Canada.

There is a new appreciation of the perimenopause-defined as the early and late menopause transition stages as well as the early postmenopause-as a window of vulnerability for the development of both depressive symptoms and major depressive episodes. However, clinical recommendations on how to identify, characterize and treat clinical depression are lacking. To address this gap, an expert panel was convened to systematically review the published literature and develop guidelines on the evaluation and management of perimenopausal depression. Read More

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http://dx.doi.org/10.1089/jwh.2018.27099.mensocrecDOI Listing
February 2019
4 Reads

Oncoplastic Breast Consortium consensus conference on nipple-sparing mastectomy.

Breast Cancer Res Treat 2018 Dec 4;172(3):523-537. Epub 2018 Sep 4.

Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Purpose: Indications for nipple-sparing mastectomy (NSM) have broadened to include the risk reducing setting and locally advanced tumors, which resulted in a dramatic increase in the use of NSM. The Oncoplastic Breast Consortium consensus conference on NSM and immediate reconstruction was held to address a variety of questions in clinical practice and research based on published evidence and expert panel opinion.

Methods: The panel consisted of 44 breast surgeons from 14 countries across four continents with a background in gynecology, general or reconstructive surgery and a practice dedicated to breast cancer, as well as a patient advocate. Read More

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http://dx.doi.org/10.1007/s10549-018-4937-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245050PMC
December 2018
17 Reads

Guidelines for the evaluation and treatment of perimenopausal depression: summary and recommendations.

Menopause 2018 Oct;25(10):1069-1085

Department of Psychiatry, Queen's University School of Medicine, Ontario CA.

There is a new appreciation of the perimenopause - defined as the early and late menopause transition stages as well as the early postmenopause - as a window of vulnerability for the development of both depressive symptoms and major depressive episodes. However, clinical recommendations on how to identify, characterize and treat clinical depression are lacking. To address this gap, an expert panel was convened to systematically review the published literature and develop guidelines on the evaluation and management of perimenopausal depression. Read More

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http://dx.doi.org/10.1097/GME.0000000000001174DOI Listing
October 2018
15 Reads

Systemic Treatment of Metastatic/Recurrent Uterine Leiomyosarcoma: A Changing Paradigm.

Oncologist 2018 Dec 23;23(12):1533-1545. Epub 2018 Aug 23.

Department of Obstetrics and Gynecology, University of Cincinnati Cancer Institute and College of Medicine, Cincinnati, Ohio, USA

The treatment of metastatic and recurrent uterine leoimyosarcoma (uLMS) has evolved rapidly in the past several years. Leoimyosarcoma is extremely aggressive and responds poorly to traditional chemotherapeutics. Recent regulatory approval of novel treatment options has significantly expanded the therapeutic armamentarium, and the addition of these therapies has challenged clinicians to select and optimally sequence these new compounds. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0095DOI Listing
December 2018
13 Reads

An overview of properties of Amphora (Acidform) contraceptive vaginal gel.

Authors:
Anita L Nelson

Expert Opin Drug Saf 2018 Sep 3;17(9):935-943. Epub 2018 Sep 3.

a Department of Obstetrics and Gynecology , Western University of Health Sciences , Pomona , CA , USA.

Introduction: Although only a minority of contracepting women rely solely on spermicides, they may soon be the only ongoing female method available without a prescription in the United States. Spermicides are also combined with other methods for additional pregnancy protection and/or lubrication. Nonoxynol-9 (N-9), the active ingredient in most spermicides, is cytotoxic and may increase risk of transmission of HIV and other sexually transmitted infections, especially in high-risk women. Read More

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http://dx.doi.org/10.1080/14740338.2018.1515197DOI Listing
September 2018
16 Reads

Child sexual abuse - Initial suspicion and legal outcome.

Forensic Sci Int 2018 Oct 30;291:39-43. Epub 2018 Jun 30.

Research Unit, Police College of Finland, Tampere, Finland; Faculty of Social Science, University of Tampere, Finland.

Objectives: To evaluate the association of primary reason to suspect child sexual abuse with the legal end-point in medically examined, police reported cases.

Study Design: Observational post hoc analysis of retrospective review of records of 155 medically examined, police reported alleged child sexual abuse (CSA) cases during 2001-2009. Primary referral indications for medical examinations or criminal investigations were analyzed with an end-point in the legal process. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.06.032DOI Listing
October 2018
1 Read

The Reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) Checklist: A Joint Statement by the ERAS and ERAS USA Societies.

World J Surg 2019 01;43(1):1-8

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: Enhanced recovery after surgery (ERAS) programs are multimodal care pathways designed to minimize the physiological and psychological impact of surgery for patients. Increased compliance with ERAS guidelines is associated with improved patient outcomes across surgical types. As ERAS programs have proliferated, an unintentional effect has been significant variation in how ERAS-related studies are reported in the literature. Read More

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http://dx.doi.org/10.1007/s00268-018-4753-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313353PMC
January 2019
33 Reads

Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer.

Expert Opin Ther Targets 2018 09 6;22(9):745-763. Epub 2018 Sep 6.

d Department of Obstetrics and Gynecology , Technical University of Munich , Munich , Germany.

Introduction: Aberrant levels of kallikrein-related peptidases (KLK1-15) have been linked to cancer cell proliferation, invasion and metastasis. In ovarian cancer, the KLK proteolytic network has a crucial role in the tissue and tumor microenvironment. Publically available ovarian cancer genome and expression data from multiple patient cohorts show an upregulation of most KLKs. Read More

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http://dx.doi.org/10.1080/14728222.2018.1512587DOI Listing
September 2018
10 Reads

Management of Pregnancy with Klippel-Trenaunay-Weber Syndrome: A Case Report and Review.

Authors:
Rati Chadha

Case Rep Obstet Gynecol 2018 12;2018:6583562. Epub 2018 Jul 12.

Department of Obstetrics and Gynecology; Division of Maternal Fetal Medicine, Foothills Medical Center, University of Calgary, Calgary, AB, Canada.

Background: Klippel-Trenaunay-Weber syndrome is a rare neurocutaneous syndrome with vascular involvement. Given the rarity of the syndrome, its management in pregnancy is based on the outcome of a few case reports and expert opinion.

Case Summary: The management of a complicated case with its antepartum, intrapartum, and postpartum concerns has been addressed in this review. Read More

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https://www.hindawi.com/journals/criog/2018/6583562/
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http://dx.doi.org/10.1155/2018/6583562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077650PMC
July 2018
17 Reads

Vasa previa: prenatal diagnosis and management.

Curr Opin Obstet Gynecol 2018 Dec;30(6):385-391

Academic Department of Obstetrics and Gynaecology, EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.

Purpose Of Review: Vasa previa is a rare disorder of placentation associated with a high rate of perinatal morbidity and mortality when undetected before delivery. We have evaluated the recent evidence for prenatal diagnosis and management of vasa previa.

Recent Findings: Around 85% of cases of vasa previa have one or more identifiable risk factors including in-vitro fertilization, multiple gestations, bilobed, succenturiate or low-lying placentas, and velamentous cord insertion. Read More

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http://Insights.ovid.com/crossref?an=00001703-900000000-9930
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http://dx.doi.org/10.1097/GCO.0000000000000478DOI Listing
December 2018
5 Reads

Inherited Bleeding Disorders in the Obstetric Patient.

Transfus Med Rev 2018 10 12;32(4):237-243. Epub 2018 Jul 12.

Bloodworks Northwest, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA. Electronic address:

Inherited bleeding disorders increase the risk of bleeding in the obstetric patient. Randomized controlled trials to compare prophylactic or therapeutic interventions are rare, and guidance documents rely heavily on expert opinion. Here we report the results of a systematic review of the literature for the treatment and prevention of peripartum bleeding in women with an inherited bleeding disorder. Read More

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http://dx.doi.org/10.1016/j.tmrv.2018.06.003DOI Listing
October 2018
12 Reads

Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention.

Environ Health Prev Med 2018 Aug 9;23(1):36. Epub 2018 Aug 9.

Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Malá Hora 4, 036 01, Martin, Slovak Republic.

Cancerous tissue transformation developing usually over years or even decades of life is a highly complex process involving strong stressors damaging DNA, chronic inflammation, comprehensive interaction between relevant molecular pathways, and cellular cross-talk within the neighboring tissues. Only the minor part of all cancer cases are caused by inborn predisposition; the absolute majority carry a sporadic character based on modifiable risk factors which play a central role in cancer prevention. Amongst most promising candidates for dietary supplements are bioactive phytochemicals demonstrating strong anticancer effects. Read More

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http://dx.doi.org/10.1186/s12199-018-0724-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085646PMC
August 2018
1 Read

Cross-cultural validation of the Brazilian version of the spiritual care competence scale.

Palliat Support Care 2018 Aug 3:1-6. Epub 2018 Aug 3.

Professor of Healthcare and Spirituality, Christian University of Applied Sciences Viaa,Zwolle,Netherlands.

Objective: This study describes the cross-cultural validation and psychometric evaluation of the Spiritual Care Competence Scale - Brazilian Portuguese version. This reliable and valid instrument is recommended in the literature to measure the outcomes of the education process in the development of spiritual care competences.

Method: This is a cross-sectional validation study following the stages proposed by Beaton et al. Read More

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http://dx.doi.org/10.1017/S1478951518000159DOI Listing
August 2018
1 Read