2,334 results match your criteria Expert Review of Neurotherapeutics[Journal]


Neuromodulation for the treatment of primary headache syndromes.

Expert Rev Neurother 2019 Feb 22. Epub 2019 Feb 22.

a Department of Systems Neuroscience , University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

Introduction Neuromodulation techniques play an increasing role in the treatment of primary headaches. While initially reserved for refractory cases they are now increasingly taken into consideration in earlier treatment phases and in non-refractory situations. One of the main reasons of this paradigm shift is that most neuromodulation techniques are better tolerated as compared to the majority of pharmacological approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1585243DOI Listing
February 2019

Modification of CSF findings in multiple sclerosis in the era of rapidly expanding treatment options.

Expert Rev Neurother 2019 Feb 21. Epub 2019 Feb 21.

a Department of Neurology , University Medical Center , 37075 Göttingen , Germany.

Objectives: The detection of cerebrospinal fluid (CSF)-specific oligoclonal bands (OCB) as well as an elevated antibody production directed against neurotrophic viruses remain hallmark findings in multiple sclerosis (MS). In general, individual patients show a unique pattern of OCB, which is believed to persist over time. Here, the authors revisited this assumption and investigated to what extent common anti-inflammatory MS medications can alter the level of immunoglobulins produced within the CSF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1583557DOI Listing
February 2019

Developments in depression in epilepsy: screening, diagnosis and treatment.

Authors:
Marco Mula

Expert Rev Neurother 2019 Feb 20. Epub 2019 Feb 20.

a Institute of Medical and Biomedical Education, St George's University of London and The Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust , London , United Kingdom.

Introduction: Depression is one of the most frequent comorbidities in epilepsy affecting between 17% and 22% of patients but it is still underdiagnosed and undertreated. Areas covered: This paper discusses recent advances about screening, diagnosis and treatment of depression in epilepsy taking into account the heterogeneity of clinical scenarios where depression can occur. Expert opinion: A number of screening instruments are now validated for adults with epilepsy and their psychometric properties are discussed but the NDDIE is the most practical and cost-effective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1585244DOI Listing
February 2019

Objective and biological markers in bipolar spectrum presentations.

Expert Rev Neurother 2019 Feb 14. Epub 2019 Feb 14.

a Department of Psychiatry , University of British Columbia , 2255 Wesbrook Mall, Vancouver , BC , Canada V6T 2A1.

Introduction: Subthreshold presentations of bipolarity (BSPs) pose a diagnostic conundrum, in terms of whether they should be conceptualized and treated similarly as traditionally defined bipolar disorders (BD). While it has been argued that BSPs are on a pathophysiologic continuum with traditionally defined BDs, there has been limited examination of biological and objective markers in these presentations to validate this assertion. Areas covered: The authors review studies examining genetic, neurobiological, cognitive and peripheral markers in BSPs, encompassing clinical and non-clinical populations with subthreshold hypo/manic symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1580145DOI Listing
February 2019
3 Reads

Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.

Expert Rev Neurother 2019 Feb 13:1-18. Epub 2019 Feb 13.

a Department of Molecular Pharmacology , Albert Einstein College of Medicine , Bronx , NY , USA.

Introduction: Iron (Fe) and manganese (Mn) are essential nutrients for humans. They act as cofactors for a variety of enzymes. In the central nervous system (CNS), these two metals are involved in diverse neurological activities. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1581608DOI Listing
February 2019
7 Reads
2.834 Impact Factor

Cariprazine for the treatment of bipolar depression: a review.

Expert Rev Neurother 2019 Feb 12:1-7. Epub 2019 Feb 12.

a Mood Disorders Psychopharmacology Unit , University Health Network , Toronto , Canada.

Introduction: Depressive symptoms and episodes dominate the course of bipolar disorder. The morbidity of bipolar disorder is disproportionately mediated by depressive symptoms; economic costs of bipolar disorder are also disproportionately due to unremitting depressive symptoms. Relatively few treatment options have established unequivocal efficacy in the treatment of bipolar depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1580571DOI Listing
February 2019
1 Read

Sensory-targeted cognitive training for schizophrenia.

Expert Rev Neurother 2019 Feb 9:1-15. Epub 2019 Feb 9.

a INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team , Lyon, F-69678 , France.

Introduction: Auditory and visual dysfunctions are key pathophysiological features of schizophrenia (Sz). Therefore, remedial interventions that directly target such impairments could potentially drive gains in higher-order cognition (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1581609DOI Listing
February 2019
1 Read

Emerging targets and uses of neuromodulation for pain.

Expert Rev Neurother 2019 Feb 25;19(2):109-118. Epub 2019 Jan 25.

a Spaulding Neuromodulation Center, Spaulding Rehabilitation Center and Massachusetts General Hospital , Harvard Medical School , Boston , Massachusetts (MA) , USA.

Introduction: There has been great development in the testing of invasive and non-invasive neuromodulation for chronic pain. To date, it is known that central and peripheral stimulation targets, combined or not, may influence chronic pain sensation. Although most of the significant results of chronic pain studies come from motor cortex stimulation, novel targets are being explored to increase effect sizes and to induce pain relief in non-responders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1567332DOI Listing
February 2019

Imaging in the diagnosis of idiopathic inflammatory myopathies; indications and utility.

Expert Rev Neurother 2019 Feb 7;19(2):173-184. Epub 2019 Feb 7.

b School of Medicine , Notre Dame University Australia , Fremantle , Australia.

Introduction: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of muscle diseases that carry a significant morbidity and mortality risk. The utilization of imaging in the diagnostic pathway of IIM is therefore important to obtain early diagnosis and even monitor patients over time. Areas covered: Magnetic resonance imaging (MRI) has been the main imaging modality used to detect myositis but limitations include cost and accessibility, leading to delays in time to scan, and patient contraindications. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1572507DOI Listing
February 2019
5 Reads
2.834 Impact Factor

Approaching drug-induced parkinsonism from a neurohospitalist perspective.

Authors:
Jason Margolesky

Expert Rev Neurother 2019 Feb 16;19(2):93-95. Epub 2019 Jan 16.

a Department of Neurology , University of Miami Miller School of Medicine , Miami , Fl , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1569515DOI Listing
February 2019
1 Read

Erenumab for episodic migraine prophylaxis.

Expert Rev Neurother 2019 Jan 7:1-7. Epub 2019 Jan 7.

a Department of Neurology and Experimental Neurology , Charite - Universitatsmedizin , Berlin , Germany.

Introduction: This paper reviews placebo-controlled randomized double-blind studies with erenumab for the prevention of migraine. Erenumab is a fully human monoclonal antibody (mAb), which specifically blocks the calcitonin gene-related peptide (GGRP) receptor. Areas covered: This manuscript was based on articles written in English located on PubMed using the following search terms: episodic and chronic migraine, migraine prophylaxis and prevention, CGRP, CGRP receptor, CGRP receptor antagonist, erenumab, treatment failures, and trigeminal nerve. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1565996DOI Listing
January 2019
1 Read

Improvement of gait and balance by non-invasive brain stimulation: its use in rehabilitation.

Authors:
Soumya Ghosh

Expert Rev Neurother 2019 Feb 7;19(2):133-144. Epub 2019 Jan 7.

a Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science , University of Western Australia , Nedlands , Australia.

Introduction: Gait and balance impairments are common in many neurological disorders and among the elderly, are often difficult to treat, and have a significant effect on quality of life. Areas covered: Non-invasive brain stimulation (NIBS) technologies have been recognized for their therapeutic potential in various neurologic and psychiatric disorders. There is increasing interest in treatment of gait and balance impairment using newer modalities such as NIBS. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1564042DOI Listing
February 2019
12 Reads

Cortico-limbic connectivity as a possible biomarker for bipolar disorder: where are we now?

Expert Rev Neurother 2019 Feb 1;19(2):159-172. Epub 2019 Jan 1.

a Psychiatry & Clinical Psychobiology , Division of Neuroscience, Scientific Institute Ospedale San Raffaele , Milano , Italy.

Introduction: The fronto-limbic network has been suggested as a key circuitry in the pathophysiology and maintenance of bipolar disorder. In the past decade, a disrupted connectivity within prefrontal-limbic structures was identified as a promising candidate biomarker for the disorder. Areas Covered: In this review, the authors examine current literature in terms of the structural, functional and effective connectivity in bipolar disorder, integrating recent findings of imaging genetics and machine learning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1562338DOI Listing
February 2019
2 Reads

Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis.

Expert Rev Neurother 2018 Dec 27:1-13. Epub 2018 Dec 27.

a NeuroCure Clinical Research Center , Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany.

Introduction: Multiple Sclerosis (MS) is the most common chronic autoimmune neuroinflammatory condition in young adults. It is often accompanied by optic neuritis (ON) and retinal neuro-axonal damage causing visual disturbances. Optical coherence tomography (OCT) is a sensitive non-invasive method for quantifying intraretinal layer volumes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1559051DOI Listing
December 2018
1 Read

Unusual gait disorders: a phenomenological approach and classification.

Expert Rev Neurother 2019 Feb 30;19(2):119-132. Epub 2018 Dec 30.

a Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, UHN, Division of Neurology , University of Toronto , Toronto , ON , Canada.

Introduction: Gait impairment is a very common problem in clinical practice. Multiple classifications of gait disorders are available based on anatomy, etiology, pathology and phenomenology. These classifications provide a diagnostic guide but do not clearly explain the pathophysiology of some gait disorders, which can sometimes hinder the diagnostic process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1562337DOI Listing
February 2019
7 Reads

Ocrelizumab for the treatment of multiple sclerosis.

Expert Rev Neurother 2019 Feb 28;19(2):97-108. Epub 2018 Dec 28.

a Département de Neurologie , Centre Hospitalier Universitaire de Strasbourg, Avenue Moliére , 67200 Strasbourg , France.

Introduction: In the past decade, the role of B cells in the pathogenesis of multiple sclerosis (MS) is coming to the forefront. Depletion of B cells by anti-CD20 monoclonal antibodies (mAbs) has proved to decrease the activity of the relapsing-remitting MS (RRMS) and the progression of primary progressive MS (PPMS). Areas covered: In this review, the authors discuss the rationale of the depletion of B cells in RRMS and PPMS across recent studies on the role of B cells in the pathogenesis of MS; previous clinical trials with treatments targeting B cells; the mechanism of action of ocrelizumab - a second generation anti-CD20 mAb - and recent phase III clinical trials with ocrelizumab in RRMS and PPMS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1561284DOI Listing
February 2019
1 Read

Multidisciplinary care for people with Parkinson's disease: the new kids on the block!

Expert Rev Neurother 2019 Feb 9;19(2):145-157. Epub 2019 Jan 9.

a Department of Neurology, Donders Institute for Brain, Cognition and Behaviour , Radboud University Medical Center , Nijmegen , The Netherlands.

Introduction: Parkinson's disease (PD) is a chronic multisystem disorder that causes a wide variety of motor and non-motor symptoms. Over time, the progressive nature of the disease increases the risk of complications such as falls and loss of independence, having a profound impact on quality of life. The complexity and heterogeneity of symptoms therefore warrant a holistic, multidisciplinary approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1561285DOI Listing
February 2019
4 Reads

Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures.

Expert Rev Neurother 2018 Dec 18:1-12. Epub 2018 Dec 18.

a Mid-Atlantic Epilepsy and Sleep Center , Bethesda , MD , USA.

Introduction: Perampanel is an antiepileptic drug approved in the USA and Europe as monotherapy and adjunctive therapy for focal onset seizures and as adjunctive therapy for generalized tonic-clonic seizures. Areas covered: This an overview of animal data, pharmacokinetics, and clinical data published on Perampanel indexed in PubMed. Expert opinion: Pharmacological studies suggest that perampanel acts via noncompetitive antagonism of the ionotropic AMPA receptor of glutamate. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1555474DOI Listing
December 2018
6 Reads

Neuromodulation - Science and Practice in Epilepsy: Vagus Nerve Stimulation, Thalamic Deep Brain Stimulation, and Responsive NeuroStimulation.

Expert Rev Neurother 2018 Dec 11:1-13. Epub 2018 Dec 11.

a Department of Neurology and Neurological Sciences , Stanford University School of Medicine , Stanford , CA , USA.

Introduction: Neuromodulation devices can be safe and effective for the treatment of drug-resistant epilepsy. A body of scientific work supports peripheral, subcortical and cortical targets, each with different fundamental methods of action. Areas covered: High-quality evidence is available for vagal nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1554433DOI Listing
December 2018
1 Read

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1555475DOI Listing
December 2018
16 Reads

An update on ketamine and its two enantiomers as rapid-acting antidepressants.

Expert Rev Neurother 2018 Dec 4:1-10. Epub 2018 Dec 4.

a Division of Clinical Neuroscience , Chiba University Center for Forensic Mental Health , Chiba , Japan.

Introduction: Depression is one of the most disabling diseases worldwide. Approximately one-third of depressed patients are treatment-resistant to the currently available antidepressants and there is a significant therapeutic time lag of weeks to months. There is a clear unmet need for rapid-acting and more efficacious treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1554434DOI Listing
December 2018
3 Reads
2.834 Impact Factor

Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis.

Expert Rev Neurother 2018 Dec 4. Epub 2018 Dec 4.

c Department of Immunology.

Introduction: The gut microbiome helps to maintain a person's healthy state while perturbations in its function often leading to the development of inflammatory diseases including multiple sclerosis (MS). Consequently, gut-commensals which restore homeostasis have the potential to become novel therapeutic options for treating MS. MS patients have presented gut microbial dysbiosis with a reduction in bacteria belonging to the Prevotella genus. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1555473DOI Listing
December 2018
10 Reads

Application of advanced MRI techniques to monitor pharmacologic and rehabilitative treatment in multiple sclerosis: current status and future perspectives.

Expert Rev Neurother 2018 Nov 30. Epub 2018 Nov 30.

a Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience , San Raffaele Scientific Institute, Vita-Salute San Raffaele University , Milan , Italy .

Introduction: Advances in magnetic resonance imaging (MRI) technology and analyses are improving our understanding of the pathophysiology of multiple sclerosis (MS). Due to their ability to grade the presence of irreversible tissue loss, microstructural tissue abnormalities, metabolic changes and functional plasticity, the application of these techniques is also expanding our knowledge on the efficacy and mechanisms of action of different pharmacological and rehabilitative treatments. Areas covered. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2019.1555038DOI Listing
November 2018
13 Reads

An update on diagnosis and therapy of metabolic myopathies.

Authors:
Josef Finsterer

Expert Rev Neurother 2018 Dec 27;18(12):933-943. Epub 2018 Nov 27.

a Krankenanstalt Rudolfstiftung, Messerli Institute , Veterinary University of Vienna , Vienna , Austria.

Introduction: Metabolic myopathies are a heterogeneous group of disorders characterized by inherited defects of enzymatic pathways involved in muscle fiber energetics. Diagnosing metabolic myopathies requires a thoroughly taken individual and family history, a meticulous neurologic exam, exercise tests, blood and urine tests, needle-electromyography, nerve-conduction studies, muscle biopsy, targeted genetic tests, or next-generation sequencing. There is limited evidence from the literature to guide treatment of metabolic myopathies. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1550360DOI Listing
December 2018
13 Reads

Pharmacotherapy of postpartum obsessive-compulsive disorder: a systematic review.

Authors:
Verinder Sharma

Expert Rev Neurother 2018 Dec 27;18(12):925-931. Epub 2018 Nov 27.

a Department of Psychiatry , University of Western Ontario & Parkwood Institute , London , ON , Canada.

Introduction: Despite the common occurrence of obsessive-compulsive disorder (OCD) after childbirth, the role of pharmacotherapy in its management is unclear. Areas covered: This systematic review aims to determine the role of drugs in the acute and preventative treatment of postpartum OCD. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, four electronic databases including Medline/PubMed, PsycINFO, the Cochrane Database of Systematic Reviews, and Google Scholar were searched. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1549991DOI Listing
December 2018
16 Reads

Biomarkers for bipolar disorder: current status and challenges ahead.

Expert Rev Neurother 2019 Jan 28;19(1):67-81. Epub 2018 Nov 28.

a Department of Psychiatry & Behavioral Sciences , McGovern Medical School, UT Health , Houston , TX , USA.

Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1550361DOI Listing
January 2019
16 Reads

Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies.

Expert Rev Neurother 2018 Oct 24:1-3. Epub 2018 Oct 24.

a Department of Biochemical Sciences , Sapienza University of Rome , Rome , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1540932DOI Listing
October 2018
1 Read

Autoimmune autonomic ganglionopathy: an update on diagnosis and treatment.

Expert Rev Neurother 2018 Dec 1;18(12):953-965. Epub 2018 Nov 1.

a Department of Neurology, Graduate School of Medical Sciences , Kumamoto University , Kumamoto , Japan.

Introduction: Autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder that leads to autonomic failure. The disorder is associated with autoantibodies to the ganglionic nicotinic acetylcholine receptor (gAChR). We subsequently reported that AAG is associated with an overrepresentation of psychiatric symptoms, sensory disturbance, autoimmune diseases, and endocrine disorders. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1540304DOI Listing
December 2018
38 Reads

rTMS for the treatment of Alzheimer's disease: where should we be stimulating?

Expert Rev Neurother 2018 Dec 29;18(12):903-905. Epub 2018 Oct 29.

c Department of Veterans Affairs Palo Alto Health Care System , Sierra Pacific MIRECC , Palo Alto , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1538792DOI Listing
December 2018
1 Read

Is deep brain stimulation therapy underutilized for movement disorders?

Expert Rev Neurother 2018 12 15;18(12):899-901. Epub 2018 Nov 15.

a Fixel Center for Neurological Disorders, Department of Neurology , University of Florida , Gainesville , FL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1538791DOI Listing
December 2018
1 Read

Remediation of depression-related cognitive impairment: cognitive control training as treatment augmentation.

Expert Rev Neurother 2018 Dec 26;18(12):907-913. Epub 2018 Oct 26.

a Department of Experimental Clinical and Health Psychology , Ghent University , Ghent , Belgium.

Introduction: Despite several available evidence-based interventions for major depression relapse, rates remain high and relapse prevention programs are still scarce. To increase effectiveness, novel techniques that target underlying vulnerability factors may be a promising avenue. Depression is associated with impairments in executive functioning, which is in turn associated with poor psychosocial outcomes and more Repetitive Negative Thinking (RNT), a key vulnerability factor for relapse. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1537783DOI Listing
December 2018
9 Reads

Thunderclap headache: an update.

Expert Rev Neurother 2018 Dec 29;18(12):915-924. Epub 2018 Oct 29.

b Faculty of Medicine , National Yang-Ming University School of Medicine , Taipei , Taiwan.

Introduction: Thunderclap headache (TCH) is an excruciating headache that reaches maximal intensity within a minute. It has numerous potential etiologies, the most concerning of which is subarachnoid hemorrhage (SAH) due to high morbidity and mortality. Thus, patients with TCH must be evaluated urgently to identify the underlying cause and initiate prompt therapy. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1537782DOI Listing
December 2018
10 Reads

Rationale and patient selection for interventional therapies in Parkinson's disease.

Expert Rev Neurother 2018 11;18(11):811-823

i Parkinson's, Movement Disorders and Neurorestoration Program , National Neuroscience Institute , Riyadh , Saudi Arabia.

Introduction: Parkinson's disease (PD) is increasing in prevalence due to a growing elderly population. Although there is no cure, there are exercise therapies and medications for mild to moderate disease. For more advanced disease, infusion or surgical interventions including deep brain stimulation surgery, levodopa carbidopa intestinal gel, and subcutaneous apomorphine infusion are considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1535902DOI Listing
November 2018
27 Reads

Novel technology for mobility and balance tracking in patients with multiple sclerosis: a systematic review.

Expert Rev Neurother 2018 Nov 12;18(11):887-898. Epub 2018 Oct 12.

a Department of Kinesiology and Community Health , University of Illinois at Urbana-Champaign , Urbana , IL , USA.

Introduction: Mobility and balance impairments in patients with multiple sclerosis (MS) are major factors for decreased quality of life. Novel sensing technologies have great potential to efficiently capture subtle changes in mobility and balance performance, and thus improve current practices by providing an easy-to-implement, objective, and continuous functional tracking in MS population. Areas covered: This review details the collective findings of novel technology utilization in mobility and balance tracking in patients with MS. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1533816DOI Listing
November 2018
2 Reads

The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia.

Expert Rev Neurother 2018 Nov 10;18(11):859-869. Epub 2018 Oct 10.

b Alzheimer's Disease Research Unit , The McGill University Research Centre for Studies in Aging , Montreal , Canada.

Introduction: Cognitive assessment tools measure cognitive impairment and complement biomarkers to link cognitive symptoms with pathophysiological processes underlying dementia. However, language and cultural differences in multilingual populations can influence the interpretation of cognitive assessment tools when applied in cross-cultural and multinational studies. Areas covered: This article examines the influence of culture and language on the interpretation of the Mini-Mental State Examination, Montreal Cognitive Assessment, and Alzheimer's Disease Assessment Scale-cognitive subscale, which are more commonly used worldwide. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1532792DOI Listing
November 2018
12 Reads

BACE inhibitors in clinical development for the treatment of Alzheimer's disease.

Expert Rev Neurother 2018 Nov 24;18(11):847-857. Epub 2018 Oct 24.

j Department of Research and Development , Chiesi Farmaceutici , Parma , Italy.

Introduction: The amyloid hypothesis of Alzheimer's disease (AD) affirms that brain accumulation of amyloid-β (Aβ) oligomers and soluble aggregates represent the major pathological event of the disease. Several anti-Aβ small organic molecules, monoclonal antibodies and antigens were developed to interfere with Aβ production and clearance, including β-site amyloid precursor protein cleaving enzyme (BACE) inhibitors, blocking the first enzymatic step of Aβ formation. All these approaches, including BACE inhibitors, have failed in large randomized clinical trials (RCTs) in mild-to-moderate AD, but further studies are now being carried out in patients at early AD stages and in asymptomatic subjects at risk of developing AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1531706DOI Listing
November 2018
10 Reads
2.834 Impact Factor

Challenges and importance of measuring neurobehavioural disability in acquired brain injury: the 'St Andrew's Swansea - Neurobehavioural Outcomes Scale' (SASNOS).

Authors:
Nick Alderman

Expert Rev Neurother 2018 Nov 11;18(11):807-810. Epub 2018 Oct 11.

a Neurobehavioural Rehabilitation Services , Elysium Neurological , Badbury , Northants.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1531705DOI Listing
November 2018
9 Reads

Current and emerging ALS biomarkers: utility and potential in clinical trials.

Expert Rev Neurother 2018 Nov 8;18(11):871-886. Epub 2018 Oct 8.

a School of Medicine , Johns Hopkins University , Baltimore , MD , USA.

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder which results in progressive muscle weakness as a prominent feature. However, clinical and pathogenic heterogeneity with regard to anatomical sites of disease onset and progression overtime are important features of the disease which have frustrated attempts to inform patients about their prognosis as well as limited the potential successes of therapeutic studies. Areas covered: This article discusses: clinical biomarkers which can be measured by history, physical examination, and clinical scales of disability; genetic markers of ALS that may help to distinguish various ALS subtypes; fluid-based biomarkers are actively being pursued for their utility in understanding disease progression and prognosis; electrophysiological studies that are now widely used in ALS clinical trials; neuroimaging biomarkers whose development has been accelerated with evolving techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1530987DOI Listing
November 2018
2 Reads

Technology-based assessment of motor and nonmotor phenomena in Parkinson disease.

Expert Rev Neurother 2018 Nov 8;18(11):825-845. Epub 2018 Oct 8.

a James J and Joan A Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology , University of Cincinnati , Cincinnati , OH , USA.

Introduction: The increasing development and availability of portable and wearable technologies is rapidly expanding the field of technology-based objective measures (TOMs) in neurological disorders, including Parkinson disease (PD). Substantial challenges remain in the recognition of disease phenomena relevant to patients and clinicians, as well as in the identification of the most appropriate devices to carry out these measurements. Areas covered: The authors systematically reviewed PubMed for studies employing technology as outcome measures in the assessment of PD-associated motor and nonmotor abnormalities. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
Publisher Site
http://dx.doi.org/10.1080/14737175.2018.1530593DOI Listing
November 2018
14 Reads

Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.

Expert Rev Neurother 2018 Oct 4;18(10):793-806. Epub 2018 Oct 4.

a Department of Pediatrics and Pediatric Hematology/Oncology , Klinikum Oldenburg AöR, Medical Campus University Oldenburg , Oldenburg , Germany.

Introduction: Childhood-onset craniopharyngiomas are rare embryonic tumors of low-grade histological malignancy. Severe obesity, physical fatigue, and psychosocial deficits due to hypothalamic tumor involvement have negative impact on quality of life. Initial pretreatment involvement of hypothalamic structures and/or treatment-related lesions result in sequelae clinically associated with impaired social and physical functionality and severe neuroendocrine deficiencies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1528874DOI Listing
October 2018
4 Reads

A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.

Expert Rev Neurother 2018 Oct 20;18(10):785-791. Epub 2018 Sep 20.

a Neurology Department , Hospital Universitario Quironsalud Madrid , Pozuelo de Alarcón, Madrid , Spain.

Introduction: Multiple sclerosis (MS) is a complex disease with a heterogeneous and unpredictable clinical course. Mobility impairment after progressive paralyses and muscle tone spasticity is common. Areas covered: The prevalence, assessment, and pharmacological management of gait impairment and spasticity in MS and their effects on health-related quality of life (HRQoL) are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1510772DOI Listing
October 2018
2 Reads

Going meta on metacognitive interventions.

Expert Rev Neurother 2018 Oct 26;18(10):739-741. Epub 2018 Sep 26.

d Department of Psychology, Clinical Psychology and Psychotherapy , Eberhard Karls University Tübingen , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1520636DOI Listing
October 2018
1 Read

Deep brain stimulation for childhood dystonia: current evidence and emerging practice.

Expert Rev Neurother 2018 Oct 24;18(10):773-784. Epub 2018 Sep 24.

c Division of Neurosurgery, Department of Surgery , University of Toronto , Toronto , Canada.

Introduction: Dystonia, one of the most common childhood movement disorders, is often medically refractory and can lead to profound impacts on the child and their caretakers' quality of life. Limited efficacy of pharmacological treatments has fueled enthusiasm for innovative neurosurgical approaches, notably deep brain stimulation (DBS) as a treatment for refractory dystonia. Areas covered: DBS is increasingly applied to successfully treat childhood dystonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1523721DOI Listing
October 2018
1 Read
2.834 Impact Factor

Select hyperacute complications of ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema secondary to intravenous Alteplase.

Expert Rev Neurother 2018 Oct 24;18(10):749-759. Epub 2018 Sep 24.

a Department of Neurology , Stritch Medical Center, Loyola University Medical Center , Maywood , IL , USA.

Introduction: Remarkable advances have occurred in the management of acute ischemic stroke, especially in regards to reperfusion treatments. With advances in reperfusion treatments come the risk of complications associated with these treatments. Areas covered: The article focuses on three acute complications that can occur in the setting of acute ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema following administration of alteplase, a recombinant tissue plasminogen activator. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1521723DOI Listing
October 2018
3 Reads

New guidelines for the diagnosis and treatment of neurocysticercosis: a difficult proposal for patients in endemic countries.

Expert Rev Neurother 2018 Oct 6;18(10):743-747. Epub 2018 Sep 6.

g Division of Neurology Royal University Hospital , University of Saskatchewan , Saskatoon , Canada.

Introduction: Recent guidelines for the diagnosis and treatment for neurocysticercosis (NC) from the Infectious Disease Society of America/American Society of Tropical Medicine and Hygiene were developed to be used in the United States and Canada, where only a small fraction of NC cases occur. Areas covered: The paper discusses the strengths and weakness of the proposed guidelines. Expert commentary: Although these new guidelines bring much needed attention to a neglected parasitic disease, some of the recommendations made are based on insufficient and/or inadequate evidence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1518133DOI Listing
October 2018
2 Reads

Diagnostic challenges in rapidly progressive dementia.

Expert Rev Neurother 2018 Oct 17;18(10):761-772. Epub 2018 Sep 17.

a Clinical Dementia Center and National TSE Reference Center, Department of Neurology , Goettingen University Medical Center , Goettingen , Germany.

Introduction: Rapidly progressive dementia is a syndrome caused by numerous disease entities. Accurate diagnosis is crucial as substantial proportion of these diseases is highly treatable. Others might implicate specific hygienic problems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1519397DOI Listing
October 2018
2 Reads

Interactions between tumor-associated macrophages and tumor cells in glioblastoma: unraveling promising targeted therapies.

Expert Rev Neurother 2018 Sep 22;18(9):729-737. Epub 2018 Aug 22.

a Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP , Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix , Service de Neurologie 2-Mazarin, Paris , France.

Introduction: Glioblastoma (GBM) is the deadliest primary malignant central nervous system (CNS) tumor with a median overall survival of 15 months despite a very intensive therapeutic regimen including maximal safe surgery, radiotherapy, and chemotherapy. Therefore, GBM treatment still raises major biological and therapeutic challenges. Areas covered: One of the hallmarks of the GBM is its tumor microenvironment including tumor-associated macrophages (TAM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1510321DOI Listing
September 2018
13 Reads

An update on the treatment of Restless Legs Syndrome/Willis-Ekbom Disease: prospects and challenges.

Expert Rev Neurother 2018 Sep 22;18(9):705-713. Epub 2018 Aug 22.

a Department of Clinical Neurosciences, Neurology - Sleep Disorders Center , IRCCS San Raffaele Scientific Institute , Milan , Italy.

Introduction: Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a sleep disorder characterized by an urge to move the legs, frequently associated or triggered by unpleasant sensations in the lower limbs that affects approximately 2.5% of adults. Therapy and management of RLS/WED require long-term interventions, since the typical manifestation of this disorder is chronic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1510773DOI Listing
September 2018
2 Reads

Reminiscence therapy for dementia: an abridged Cochrane systematic review of the evidence from randomized controlled trials.

Expert Rev Neurother 2018 Sep 28;18(9):715-727. Epub 2018 Aug 28.

c Institute of Mental Health , University of Nottingham , Nottingham , UK.

Introduction: Reminiscence therapy (RT) is a popular psychosocial intervention widely used in dementia care. It involves discussion of past events and experiences, using tangible prompts to evoke memories or stimulate conversation. Areas covered: The aim of this review is to evaluate the effectiveness of RT for people with dementia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2018.1509709DOI Listing
September 2018
23 Reads