2,317 results match your criteria Expert Review of Neurotherapeutics[Journal]


Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures.

Expert Rev Neurother 2018 Dec 18:1-12. Epub 2018 Dec 18.

a Mid-Atlantic Epilepsy and Sleep Center , Bethesda , MD , USA.

Introduction: Perampanel is an antiepileptic drug approved in the USA and Europe as monotherapy and adjunctive therapy for focal onset seizures and as adjunctive therapy for generalized tonic-clonic seizures. Areas covered: This an overview of animal data, pharmacokinetics, and clinical data published on Perampanel indexed in PubMed. Expert opinion: Pharmacological studies suggest that perampanel acts via noncompetitive antagonism of the ionotropic AMPA receptor of glutamate. Read More

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http://dx.doi.org/10.1080/14737175.2019.1555474DOI Listing
December 2018

Neuromodulation - Science and Practice in Epilepsy: Vagus Nerve Stimulation, Thalamic Deep Brain Stimulation, and Responsive NeuroStimulation.

Expert Rev Neurother 2018 Dec 11:1-13. Epub 2018 Dec 11.

a Department of Neurology and Neurological Sciences , Stanford University School of Medicine , Stanford , CA , USA.

Introduction: Neuromodulation devices can be safe and effective for the treatment of drug-resistant epilepsy. A body of scientific work supports peripheral, subcortical and cortical targets, each with different fundamental methods of action. Areas covered: High-quality evidence is available for vagal nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). Read More

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http://dx.doi.org/10.1080/14737175.2019.1554433DOI Listing
December 2018

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
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http://dx.doi.org/10.1080/14737175.2019.1555475DOI Listing
December 2018
4 Reads

An update on ketamine and its two enantiomers as rapid-acting antidepressants.

Expert Rev Neurother 2018 Dec 4:1-10. Epub 2018 Dec 4.

a Division of Clinical Neuroscience , Chiba University Center for Forensic Mental Health , Chiba , Japan.

Introduction: Depression is one of the most disabling diseases worldwide. Approximately one-third of depressed patients are treatment-resistant to the currently available antidepressants and there is a significant therapeutic time lag of weeks to months. There is a clear unmet need for rapid-acting and more efficacious treatments. Read More

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http://dx.doi.org/10.1080/14737175.2019.1554434DOI Listing
December 2018
2 Reads

Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis.

Expert Rev Neurother 2018 Dec 4. Epub 2018 Dec 4.

c Department of Immunology.

Introduction: The gut microbiome helps to maintain a person's healthy state while perturbations in its function often leading to the development of inflammatory diseases including multiple sclerosis (MS). Consequently, gut-commensals which restore homeostasis have the potential to become novel therapeutic options for treating MS. MS patients have presented gut microbial dysbiosis with a reduction in bacteria belonging to the Prevotella genus. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
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http://dx.doi.org/10.1080/14737175.2019.1555473DOI Listing
December 2018
3 Reads

Application of advanced MRI techniques to monitor pharmacologic and rehabilitative treatment in multiple sclerosis: current status and future perspectives.

Expert Rev Neurother 2018 Nov 30. Epub 2018 Nov 30.

a Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience , San Raffaele Scientific Institute, Vita-Salute San Raffaele University , Milan , Italy .

Introduction: Advances in magnetic resonance imaging (MRI) technology and analyses are improving our understanding of the pathophysiology of multiple sclerosis (MS). Due to their ability to grade the presence of irreversible tissue loss, microstructural tissue abnormalities, metabolic changes and functional plasticity, the application of these techniques is also expanding our knowledge on the efficacy and mechanisms of action of different pharmacological and rehabilitative treatments. Areas covered. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
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http://dx.doi.org/10.1080/14737175.2019.1555038DOI Listing
November 2018
7 Reads

An update on diagnosis and therapy of metabolic myopathies.

Authors:
Josef Finsterer

Expert Rev Neurother 2018 Dec 27;18(12):933-943. Epub 2018 Nov 27.

a Krankenanstalt Rudolfstiftung, Messerli Institute , Veterinary University of Vienna , Vienna , Austria.

Introduction: Metabolic myopathies are a heterogeneous group of disorders characterized by inherited defects of enzymatic pathways involved in muscle fiber energetics. Diagnosing metabolic myopathies requires a thoroughly taken individual and family history, a meticulous neurologic exam, exercise tests, blood and urine tests, needle-electromyography, nerve-conduction studies, muscle biopsy, targeted genetic tests, or next-generation sequencing. There is limited evidence from the literature to guide treatment of metabolic myopathies. Read More

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http://dx.doi.org/10.1080/14737175.2018.1550360DOI Listing
December 2018
5 Reads

Pharmacotherapy of postpartum obsessive-compulsive disorder: a systematic review.

Authors:
Verinder Sharma

Expert Rev Neurother 2018 Dec 27;18(12):925-931. Epub 2018 Nov 27.

a Department of Psychiatry , University of Western Ontario & Parkwood Institute , London , ON , Canada.

Introduction: Despite the common occurrence of obsessive-compulsive disorder (OCD) after childbirth, the role of pharmacotherapy in its management is unclear. Areas covered: This systematic review aims to determine the role of drugs in the acute and preventative treatment of postpartum OCD. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, four electronic databases including Medline/PubMed, PsycINFO, the Cochrane Database of Systematic Reviews, and Google Scholar were searched. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1549991DOI Listing
December 2018
5 Reads

Biomarkers for bipolar disorder: current status and challenges ahead.

Expert Rev Neurother 2018 Nov 19:1-15. Epub 2018 Nov 19.

a Department of Psychiatry & Behavioral Sciences , McGovern Medical School, UT Health , Houston , TX , USA.

Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Read More

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http://dx.doi.org/10.1080/14737175.2019.1550361DOI Listing
November 2018
3 Reads

Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies.

Expert Rev Neurother 2018 Oct 24:1-3. Epub 2018 Oct 24.

a Department of Biochemical Sciences , Sapienza University of Rome , Rome , Italy.

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http://dx.doi.org/10.1080/14737175.2019.1540932DOI Listing
October 2018

Autoimmune autonomic ganglionopathy: an update on diagnosis and treatment.

Expert Rev Neurother 2018 Dec 1;18(12):953-965. Epub 2018 Nov 1.

a Department of Neurology, Graduate School of Medical Sciences , Kumamoto University , Kumamoto , Japan.

Introduction: Autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder that leads to autonomic failure. The disorder is associated with autoantibodies to the ganglionic nicotinic acetylcholine receptor (gAChR). We subsequently reported that AAG is associated with an overrepresentation of psychiatric symptoms, sensory disturbance, autoimmune diseases, and endocrine disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1540304DOI Listing
December 2018
14 Reads

rTMS for the treatment of Alzheimer's disease: where should we be stimulating?

Expert Rev Neurother 2018 Dec 29;18(12):903-905. Epub 2018 Oct 29.

c Department of Veterans Affairs Palo Alto Health Care System , Sierra Pacific MIRECC , Palo Alto , USA.

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http://dx.doi.org/10.1080/14737175.2018.1538792DOI Listing
December 2018

Is deep brain stimulation therapy underutilized for movement disorders?

Expert Rev Neurother 2018 12 15;18(12):899-901. Epub 2018 Nov 15.

a Fixel Center for Neurological Disorders, Department of Neurology , University of Florida , Gainesville , FL , USA.

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http://dx.doi.org/10.1080/14737175.2018.1538791DOI Listing
December 2018

Remediation of depression-related cognitive impairment: cognitive control training as treatment augmentation.

Expert Rev Neurother 2018 Dec 26;18(12):907-913. Epub 2018 Oct 26.

a Department of Experimental Clinical and Health Psychology , Ghent University , Ghent , Belgium.

Introduction: Despite several available evidence-based interventions for major depression relapse, rates remain high and relapse prevention programs are still scarce. To increase effectiveness, novel techniques that target underlying vulnerability factors may be a promising avenue. Depression is associated with impairments in executive functioning, which is in turn associated with poor psychosocial outcomes and more Repetitive Negative Thinking (RNT), a key vulnerability factor for relapse. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1537783DOI Listing
December 2018
4 Reads

Thunderclap headache: an update.

Expert Rev Neurother 2018 Dec 29;18(12):915-924. Epub 2018 Oct 29.

b Faculty of Medicine , National Yang-Ming University School of Medicine , Taipei , Taiwan.

Introduction: Thunderclap headache (TCH) is an excruciating headache that reaches maximal intensity within a minute. It has numerous potential etiologies, the most concerning of which is subarachnoid hemorrhage (SAH) due to high morbidity and mortality. Thus, patients with TCH must be evaluated urgently to identify the underlying cause and initiate prompt therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1537782DOI Listing
December 2018
8 Reads

Rationale and patient selection for interventional therapies in Parkinson's disease.

Expert Rev Neurother 2018 11;18(11):811-823

i Parkinson's, Movement Disorders and Neurorestoration Program , National Neuroscience Institute , Riyadh , Saudi Arabia.

Introduction: Parkinson's disease (PD) is increasing in prevalence due to a growing elderly population. Although there is no cure, there are exercise therapies and medications for mild to moderate disease. For more advanced disease, infusion or surgical interventions including deep brain stimulation surgery, levodopa carbidopa intestinal gel, and subcutaneous apomorphine infusion are considered. Read More

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http://dx.doi.org/10.1080/14737175.2018.1535902DOI Listing
November 2018
17 Reads

Novel technology for mobility and balance tracking in patients with multiple sclerosis: a systematic review.

Expert Rev Neurother 2018 Nov 12;18(11):887-898. Epub 2018 Oct 12.

a Department of Kinesiology and Community Health , University of Illinois at Urbana-Champaign , Urbana , IL , USA.

Introduction: Mobility and balance impairments in patients with multiple sclerosis (MS) are major factors for decreased quality of life. Novel sensing technologies have great potential to efficiently capture subtle changes in mobility and balance performance, and thus improve current practices by providing an easy-to-implement, objective, and continuous functional tracking in MS population. Areas covered: This review details the collective findings of novel technology utilization in mobility and balance tracking in patients with MS. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1533816DOI Listing
November 2018
1 Read

The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia.

Expert Rev Neurother 2018 Nov 10;18(11):859-869. Epub 2018 Oct 10.

b Alzheimer's Disease Research Unit , The McGill University Research Centre for Studies in Aging , Montreal , Canada.

Introduction: Cognitive assessment tools measure cognitive impairment and complement biomarkers to link cognitive symptoms with pathophysiological processes underlying dementia. However, language and cultural differences in multilingual populations can influence the interpretation of cognitive assessment tools when applied in cross-cultural and multinational studies. Areas covered: This article examines the influence of culture and language on the interpretation of the Mini-Mental State Examination, Montreal Cognitive Assessment, and Alzheimer's Disease Assessment Scale-cognitive subscale, which are more commonly used worldwide. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1532792DOI Listing
November 2018
10 Reads

BACE inhibitors in clinical development for the treatment of Alzheimer's disease.

Expert Rev Neurother 2018 Nov 24;18(11):847-857. Epub 2018 Oct 24.

j Department of Research and Development , Chiesi Farmaceutici , Parma , Italy.

Introduction: The amyloid hypothesis of Alzheimer's disease (AD) affirms that brain accumulation of amyloid-β (Aβ) oligomers and soluble aggregates represent the major pathological event of the disease. Several anti-Aβ small organic molecules, monoclonal antibodies and antigens were developed to interfere with Aβ production and clearance, including β-site amyloid precursor protein cleaving enzyme (BACE) inhibitors, blocking the first enzymatic step of Aβ formation. All these approaches, including BACE inhibitors, have failed in large randomized clinical trials (RCTs) in mild-to-moderate AD, but further studies are now being carried out in patients at early AD stages and in asymptomatic subjects at risk of developing AD. Read More

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http://dx.doi.org/10.1080/14737175.2018.1531706DOI Listing
November 2018
7 Reads
2.834 Impact Factor

Challenges and importance of measuring neurobehavioural disability in acquired brain injury: the 'St Andrew's Swansea - Neurobehavioural Outcomes Scale' (SASNOS).

Authors:
Nick Alderman

Expert Rev Neurother 2018 Nov 11;18(11):807-810. Epub 2018 Oct 11.

a Neurobehavioural Rehabilitation Services , Elysium Neurological , Badbury , Northants.

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http://dx.doi.org/10.1080/14737175.2018.1531705DOI Listing
November 2018
8 Reads

Current and emerging ALS biomarkers: utility and potential in clinical trials.

Expert Rev Neurother 2018 Nov 8;18(11):871-886. Epub 2018 Oct 8.

a School of Medicine , Johns Hopkins University , Baltimore , MD , USA.

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder which results in progressive muscle weakness as a prominent feature. However, clinical and pathogenic heterogeneity with regard to anatomical sites of disease onset and progression overtime are important features of the disease which have frustrated attempts to inform patients about their prognosis as well as limited the potential successes of therapeutic studies. Areas covered: This article discusses: clinical biomarkers which can be measured by history, physical examination, and clinical scales of disability; genetic markers of ALS that may help to distinguish various ALS subtypes; fluid-based biomarkers are actively being pursued for their utility in understanding disease progression and prognosis; electrophysiological studies that are now widely used in ALS clinical trials; neuroimaging biomarkers whose development has been accelerated with evolving techniques. Read More

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http://dx.doi.org/10.1080/14737175.2018.1530987DOI Listing
November 2018
1 Read

Technology-based assessment of motor and nonmotor phenomena in Parkinson disease.

Expert Rev Neurother 2018 Nov 8;18(11):825-845. Epub 2018 Oct 8.

a James J and Joan A Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology , University of Cincinnati , Cincinnati , OH , USA.

Introduction: The increasing development and availability of portable and wearable technologies is rapidly expanding the field of technology-based objective measures (TOMs) in neurological disorders, including Parkinson disease (PD). Substantial challenges remain in the recognition of disease phenomena relevant to patients and clinicians, as well as in the identification of the most appropriate devices to carry out these measurements. Areas covered: The authors systematically reviewed PubMed for studies employing technology as outcome measures in the assessment of PD-associated motor and nonmotor abnormalities. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2018.1
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http://dx.doi.org/10.1080/14737175.2018.1530593DOI Listing
November 2018
8 Reads

Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.

Expert Rev Neurother 2018 Oct 4;18(10):793-806. Epub 2018 Oct 4.

a Department of Pediatrics and Pediatric Hematology/Oncology , Klinikum Oldenburg AöR, Medical Campus University Oldenburg , Oldenburg , Germany.

Introduction: Childhood-onset craniopharyngiomas are rare embryonic tumors of low-grade histological malignancy. Severe obesity, physical fatigue, and psychosocial deficits due to hypothalamic tumor involvement have negative impact on quality of life. Initial pretreatment involvement of hypothalamic structures and/or treatment-related lesions result in sequelae clinically associated with impaired social and physical functionality and severe neuroendocrine deficiencies. Read More

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http://dx.doi.org/10.1080/14737175.2018.1528874DOI Listing
October 2018
1 Read

A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.

Expert Rev Neurother 2018 Oct 20;18(10):785-791. Epub 2018 Sep 20.

a Neurology Department , Hospital Universitario Quironsalud Madrid , Pozuelo de Alarcón, Madrid , Spain.

Introduction: Multiple sclerosis (MS) is a complex disease with a heterogeneous and unpredictable clinical course. Mobility impairment after progressive paralyses and muscle tone spasticity is common. Areas covered: The prevalence, assessment, and pharmacological management of gait impairment and spasticity in MS and their effects on health-related quality of life (HRQoL) are discussed. Read More

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http://dx.doi.org/10.1080/14737175.2018.1510772DOI Listing
October 2018
1 Read

Going meta on metacognitive interventions.

Expert Rev Neurother 2018 Oct 26;18(10):739-741. Epub 2018 Sep 26.

d Department of Psychology, Clinical Psychology and Psychotherapy , Eberhard Karls University Tübingen , Germany.

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http://dx.doi.org/10.1080/14737175.2018.1520636DOI Listing
October 2018

Deep brain stimulation for childhood dystonia: current evidence and emerging practice.

Expert Rev Neurother 2018 Oct 24;18(10):773-784. Epub 2018 Sep 24.

c Division of Neurosurgery, Department of Surgery , University of Toronto , Toronto , Canada.

Introduction: Dystonia, one of the most common childhood movement disorders, is often medically refractory and can lead to profound impacts on the child and their caretakers' quality of life. Limited efficacy of pharmacological treatments has fueled enthusiasm for innovative neurosurgical approaches, notably deep brain stimulation (DBS) as a treatment for refractory dystonia. Areas covered: DBS is increasingly applied to successfully treat childhood dystonia. Read More

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http://dx.doi.org/10.1080/14737175.2018.1523721DOI Listing
October 2018
2.834 Impact Factor

Select hyperacute complications of ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema secondary to intravenous Alteplase.

Expert Rev Neurother 2018 Oct 24;18(10):749-759. Epub 2018 Sep 24.

a Department of Neurology , Stritch Medical Center, Loyola University Medical Center , Maywood , IL , USA.

Introduction: Remarkable advances have occurred in the management of acute ischemic stroke, especially in regards to reperfusion treatments. With advances in reperfusion treatments come the risk of complications associated with these treatments. Areas covered: The article focuses on three acute complications that can occur in the setting of acute ischemic stroke: cerebral edema, hemorrhagic transformation, and orolingual angioedema following administration of alteplase, a recombinant tissue plasminogen activator. Read More

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http://dx.doi.org/10.1080/14737175.2018.1521723DOI Listing
October 2018
1 Read

New guidelines for the diagnosis and treatment of neurocysticercosis: a difficult proposal for patients in endemic countries.

Expert Rev Neurother 2018 Oct 6;18(10):743-747. Epub 2018 Sep 6.

g Division of Neurology Royal University Hospital , University of Saskatchewan , Saskatoon , Canada.

Introduction: Recent guidelines for the diagnosis and treatment for neurocysticercosis (NC) from the Infectious Disease Society of America/American Society of Tropical Medicine and Hygiene were developed to be used in the United States and Canada, where only a small fraction of NC cases occur. Areas covered: The paper discusses the strengths and weakness of the proposed guidelines. Expert commentary: Although these new guidelines bring much needed attention to a neglected parasitic disease, some of the recommendations made are based on insufficient and/or inadequate evidence. Read More

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http://dx.doi.org/10.1080/14737175.2018.1518133DOI Listing
October 2018
1 Read

Diagnostic challenges in rapidly progressive dementia.

Expert Rev Neurother 2018 Oct 17;18(10):761-772. Epub 2018 Sep 17.

a Clinical Dementia Center and National TSE Reference Center, Department of Neurology , Goettingen University Medical Center , Goettingen , Germany.

Introduction: Rapidly progressive dementia is a syndrome caused by numerous disease entities. Accurate diagnosis is crucial as substantial proportion of these diseases is highly treatable. Others might implicate specific hygienic problems. Read More

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http://dx.doi.org/10.1080/14737175.2018.1519397DOI Listing
October 2018

Interactions between tumor-associated macrophages and tumor cells in glioblastoma: unraveling promising targeted therapies.

Expert Rev Neurother 2018 Sep 22;18(9):729-737. Epub 2018 Aug 22.

a Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP , Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix , Service de Neurologie 2-Mazarin, Paris , France.

Introduction: Glioblastoma (GBM) is the deadliest primary malignant central nervous system (CNS) tumor with a median overall survival of 15 months despite a very intensive therapeutic regimen including maximal safe surgery, radiotherapy, and chemotherapy. Therefore, GBM treatment still raises major biological and therapeutic challenges. Areas covered: One of the hallmarks of the GBM is its tumor microenvironment including tumor-associated macrophages (TAM). Read More

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http://dx.doi.org/10.1080/14737175.2018.1510321DOI Listing
September 2018
9 Reads

An update on the treatment of Restless Legs Syndrome/Willis-Ekbom Disease: prospects and challenges.

Expert Rev Neurother 2018 Sep 22;18(9):705-713. Epub 2018 Aug 22.

a Department of Clinical Neurosciences, Neurology - Sleep Disorders Center , IRCCS San Raffaele Scientific Institute , Milan , Italy.

Introduction: Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a sleep disorder characterized by an urge to move the legs, frequently associated or triggered by unpleasant sensations in the lower limbs that affects approximately 2.5% of adults. Therapy and management of RLS/WED require long-term interventions, since the typical manifestation of this disorder is chronic. Read More

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http://dx.doi.org/10.1080/14737175.2018.1510773DOI Listing
September 2018
1 Read

Reminiscence therapy for dementia: an abridged Cochrane systematic review of the evidence from randomized controlled trials.

Expert Rev Neurother 2018 Sep 28;18(9):715-727. Epub 2018 Aug 28.

c Institute of Mental Health , University of Nottingham , Nottingham , UK.

Introduction: Reminiscence therapy (RT) is a popular psychosocial intervention widely used in dementia care. It involves discussion of past events and experiences, using tangible prompts to evoke memories or stimulate conversation. Areas covered: The aim of this review is to evaluate the effectiveness of RT for people with dementia. Read More

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http://dx.doi.org/10.1080/14737175.2018.1509709DOI Listing
September 2018
7 Reads

Controlled-release pregabalin in the treatment of fibromyalgia.

Expert Rev Neurother 2018 Aug 23;18(8):617-623. Epub 2018 Aug 23.

g Department of Rheumatology , ASST Fatebenefratelli-Sacco , Milan , Italy.

Introduction: Fibromyalgia (FM) is a chronic disorder whose symptoms of musculo-skeletal pain, fatigue, sleep disturbances, and cognitive impairment pervade the personal, occupational, and social aspects of a patient's life. Together with the antidepressants duloxetine and milnacipran, the anticonvulsant pregabalin (PGB) is one of the three drugs approved by the Food and Drug Administration for the treatment of FM. The aim of this narrative review is to summarize the data relating to the efficacy and safety of the controlled-release formulation of PGB (PGB-CR) in patients with FM. Read More

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http://dx.doi.org/10.1080/14737175.2018.1508344DOI Listing
August 2018
4 Reads
2.830 Impact Factor

How would we combat menopause as an Alzheimer's risk factor?

Expert Rev Neurother 2018 Sep 13;18(9):689-691. Epub 2018 Aug 13.

c Departments of Pharmacology and Neurology , University of Arizona College of Medicine , Tucson , AZ , USA.

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http://dx.doi.org/10.1080/14737175.2018.1510320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296216PMC
September 2018
6 Reads

An update on diagnostic options and considerations in limb-girdle dystrophies.

Expert Rev Neurother 2018 Sep 21;18(9):693-703. Epub 2018 Aug 21.

a Neuromuscular Center , San Camillo Hospital IRCCS , Venice , Italy.

Introduction: Limb-girdle muscular dystrophies (LGMDs) encompass a clinically heterogeneous group of rare, genetic progressive muscle disorders presenting with weakness and atrophy of predominant pelvic and shoulder muscles. The spectrum of disease severity ranges from severe childhood-onset muscular dystrophy to adult-onset dystrophy. Areas covered: The review presents an update of the clinical phenotypes and diagnostic options for LGMD including both dominant and recessive LGMD and consider their differential clinical and histopathological features. Read More

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http://dx.doi.org/10.1080/14737175.2018.1508997DOI Listing
September 2018
14 Reads

Role of the Personal KinetiGraph in the routine clinical assessment of Parkinson's disease: recommendations from an expert panel.

Expert Rev Neurother 2018 Aug 26;18(8):669-680. Epub 2018 Jul 26.

f Florey Neuroscience Institute , University of Melbourne , Parkville , Australia.

Introduction: Evaluation of people with Parkinson's disease (PD) is often complex due to heterogeneity of symptoms and disease course, including the variability of motor fluctuations and dyskinesia. Routine clinical evaluations may be incomplete, may not accurately capture important symptoms, and may not reflect day-to-day variability. While significant advances have been made in wearable ambulatory continuous objective monitoring (COM) technologies, many clinicians remain uncertain of how to incorporate them in clinical practice, including the value to clinical decision-making. Read More

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http://dx.doi.org/10.1080/14737175.2018.1503948DOI Listing
August 2018
5 Reads

Clinical and pre-clinical utility of genomics in medulloblastoma.

Expert Rev Neurother 2018 Aug 26;18(8):633-647. Epub 2018 Jul 26.

b Labatt Brain Tumour Research Centre , Hospital for Sick Children , Toronto , ON , Canada.

Introduction: Integrated genomics has significantly advanced our understanding of medulloblastoma heterogeneity. It is now clear that it actually comprises at least four distinct molecular subgroups termed Wnt/Wingless (WNT), Sonic Hedgehog (SHH), Group 3, and Group 4 with stark clinical and biological differences. Areas covered: This paper reviews advances in the classification and risk stratification of medulloblastoma, specifically integrating subgroup with clinical and cytogenetic risk factors, with a summary of the potential to lead to more precise therapies. Read More

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http://dx.doi.org/10.1080/14737175.2018.1503536DOI Listing
August 2018
11 Reads

New discoveries in progressive myoclonus epilepsies: a clinical outlook.

Expert Rev Neurother 2018 Aug 9;18(8):649-667. Epub 2018 Aug 9.

a Department of Biological Sciences and Bioengineering , Indian Institute of Technology , Kanpur , India.

Introduction: Progressive myoclonus epilepsies (PMEs) constitute a rare and heterogeneous group of genetic disorders with a distinctive triad of myoclonus, seizures, and progressive neurological deterioration. PMEs, even though rare, are arguably the severest form of epilepsies accounting for <1% of all epilepsies with age at onset varying from infancy to adulthood, depending on the disease. A majority are inherited as autosomal recessive traits, however rare types following autosomal dominant and mitochondrial inheritance are also present. Read More

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http://dx.doi.org/10.1080/14737175.2018.1503949DOI Listing
August 2018
15 Reads

Cerebrolysin: a multi-target drug for recovery after stroke.

Authors:
Michael Brainin

Expert Rev Neurother 2018 Aug 18;18(8):681-687. Epub 2018 Jul 18.

a Department of Neurosciences and Preventive Medicine , Danube University Krems , Krems , Austria.

Introduction: Cerebrolysin is a neuropeptide preparation with neurotrophic effects and promotes recovery after brain injury. Its preclinical profile promises wide applications due to its multi-target effects. Currently, Cerebrolysin is used for treatment of cerebral ischemia and neurodegeneration. Read More

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http://dx.doi.org/10.1080/14737175.2018.1500459DOI Listing
August 2018
8 Reads

Deutetrabenazine for the treatment of Huntington's chorea.

Expert Rev Neurother 2018 Aug 17;18(8):625-631. Epub 2018 Jul 17.

a Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology , Baylor College of Medicine , Houston , TX , 77030-4202 , USA.

Introduction: Huntington's disease (HD) is an inherited neurodegenerative disorder for which no disease-modifying treatment is currently available. Only symptomatic treatment can be offered. Chorea is the most common motor manifestation of HD and may interfere with daily activities, reduce quality of life, and cause injury. Read More

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http://dx.doi.org/10.1080/14737175.2018.1500178DOI Listing
August 2018
6 Reads

An update on intracerebral stem cell grafts.

Expert Rev Neurother 2018 Jul 13;18(7):557-572. Epub 2018 Jul 13.

a Department of Neurosurgery and Brain Repair , Center of Excellence for Aging and Brain Repair, USF Morsani College of Medicine , Tampa , FL , USA.

Introduction: Primary neurological disorders are notoriously debilitating and deadly, and over the past four decades stem cell therapy has emerged as a promising treatment. Translation of stem cell therapies from the bench to the clinic requires a better understanding of delivery protocols, safety profile, and efficacy in each disease. Areas covered: In this review, benefits and risks of intracerebral stem cell transplantation are presented for consideration. Read More

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http://dx.doi.org/10.1080/14737175.2018.1491309DOI Listing
July 2018
14 Reads

Advances in autoimmune myasthenia gravis management.

Expert Rev Neurother 2018 Jul 4;18(7):573-588. Epub 2018 Jul 4.

a Department of Neurology , George Washington University , Washington , DC , USA.

Introduction: Myasthenia gravis (MG) is an autoimmune neuromuscular disorder with no cure and conventional treatments limited by significant adverse effects and variable benefit. In the last decade, therapeutic development has expanded based on improved understanding of autoimmunity and financial incentives for drug development in rare disease. Clinical subtypes exist based on age, gender, thymic pathology, autoantibody profile, and other poorly defined factors, such as genetics, complicate development of specific therapies. Read More

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http://dx.doi.org/10.1080/14737175.2018.1491310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289049PMC
July 2018
14 Reads

Value of nerve biopsy in the management of peripheral neuropathies.

Expert Rev Neurother 2018 Jul 25;18(7):589-602. Epub 2018 Jun 25.

d National Reference Center for 'rare peripheral neuropathies' , University Hospital , Limoges , France.

Introduction: Peripheral neuropathy is a common symptom throughout the population, with numerous possible etiologies. The diagnosis of peripheral neuropathies (and their causes) is mainly based on clinical, electrophysiological, biological, and imaging features. Areas covered: This paper reviews the main causes of neuropathy and discusses the usefulness of nerve biopsy (NB) in such cases. Read More

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http://dx.doi.org/10.1080/14737175.2018.1489240DOI Listing
July 2018
9 Reads

Sleep disorders and the risk of stroke.

Expert Rev Neurother 2018 Jul 25;18(7):523-531. Epub 2018 Jun 25.

a Michigan Medicine Stroke Program , Cardiovascular Center , Ann Arbor , MI , USA.

Introduction: Stroke is a major cause of disability and death in the United States and across the world, and the incidence and prevalence of stroke are expected to rise significantly due to an aging population. Obstructive sleep apnea, an established independent risk factor for stroke, is a highly prevalent disease that is estimated to double the risk of stroke. It remains uncertain whether non-apnea sleep disorders increase the risk of stroke. Read More

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http://dx.doi.org/10.1080/14737175.2018.1489239DOI Listing
July 2018
7 Reads

The diagnosis of progressive supranuclear palsy: current opinions and challenges.

Expert Rev Neurother 2018 Jul 28;18(7):603-616. Epub 2018 Jun 28.

a Department of Neurology , Mayo Clinic , Rochester , MN , USA.

Introduction: Progressive supranuclear palsy (PSP) is associated with microtubule-associated protein tau dysfunction. Originally thought to result in a syndrome of atypical Parkinsonism, vertical supranuclear gaze palsy, and cognitive impairment, several additional phenotypic manifestations of PSP pathology have been described over the last 20 years. Furthermore, prototypical PSP features may develop late, making early diagnosis challenging. Read More

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http://dx.doi.org/10.1080/14737175.2018.1489241DOI Listing
July 2018
5 Reads

Efficacy and mode of action of external trigeminal neurostimulation in migraine.

Expert Rev Neurother 2018 Jul 26;18(7):545-555. Epub 2018 Jun 26.

b Research Unit of Neurophysiology of Vision and Neuro-Ophthalmology , G. B. Bietti Foundation IRCCS , Rome , Italy.

Introduction: Available preventive drug treatments for migraine lack complete efficacy and often have unpleasant adverse effects. Hence, their clinical utility and therapeutic adherence are limited. Noninvasive neurostimulation methods applied over various peripheral sites (forehead, mastoid, upper arm, cervical vagus nerve) have raised great interest because of their excellent efficacy/tolerance profile. Read More

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http://dx.doi.org/10.1080/14737175.2018.1488588DOI Listing
July 2018
5 Reads

Advances in migraine neuroimaging and clinical utility: from the MRI to the bedside.

Expert Rev Neurother 2018 Jul 25;18(7):533-544. Epub 2018 Jun 25.

a Headache Center, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences , University of Campania "Luigi Vanvitelli" , Naples , Italy.

Introduction: In current migraine clinical practice, no specific diagnostic investigations are available and therefore the diagnosis is an eminently clinical process where instrumental examinations may have a part to exclude possible causes of secondary headaches. While migraine clinical phenotype has been widely characterized, migraine pathophysiology has still a gap that might be partly bridged by structural and functional neuroimaging investigations. Areas covered: This article aims to review the recent advances in functional neuroimaging, the consequent progress in the knowledge of migraine pathophysiology and their putative application and impact in the clinical setting. Read More

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http://dx.doi.org/10.1080/14737175.2018.1486708DOI Listing

Epigenetic regulatory modifications in genetic and sporadic frontotemporal dementia.

Expert Rev Neurother 2018 Jun 5;18(6):469-475. Epub 2018 Jun 5.

a Neurodegenerative Disease Unit , University of Milan, Dino Ferrari Center, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico , Milan , Italy.

Introduction: Epigenetic modifications have recently been linked to neurodegenerative diseases, such as frontotemporal dementia (FTD), which represents the second most common form of dementia in adulthood after Alzheimer's disease (AD). Epigenetic regulation occurs at different cellular levels and serve as a way to alter genetic information not only in aging but also following environmental signals. Thus, epigenetics mechanisms could exert their function at early stage of the disease, especially in sporadic cases. Read More

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http://dx.doi.org/10.1080/14737175.2018.1481389DOI Listing

Testosterone and estrogen in multiple sclerosis: from pathophysiology to therapeutics.

Expert Rev Neurother 2018 Jun 6;18(6):515-522. Epub 2018 Jun 6.

d Departments of Neurology and Biomedicine , University Hospital Basel , Basel , Switzerland.

Introduction: Neuroprotection and remyelination are two unmet needs in the treatment of multiple sclerosis (MS). Therapeutic potential has been identified with sexual hormones, supported in women by a decrease in MS activity during the pregnancy, in men by a greater severity of symptoms and a faster progression than in women. Areas covered: The therapeutic effect of testosterone and estrogens is reviewed. Read More

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http://dx.doi.org/10.1080/14737175.2018.1481390DOI Listing