1,127 results match your criteria Expert Review of Gastroenterology and Hepatology [Journal]


Algorithms to facilitate shared decision making for the management of mild-to-moderate ulcerative colitis.

Expert Rev Gastroenterol Hepatol 2018 Oct 4. Epub 2018 Oct 4.

a Department of Gastroenterology , The Austin Hospital , Melbourne Australia.

Introduction: Non-adherence has been a key barrier to the efficacy of medical treatments in ulcerative colitis (UC). Engaging patients in their IBD care via shared decision making (SDM) to facilitate self-management may improve adherence to therapy. Areas covered: This review aims to summarize the most recent trial evidence from 2012-2017 for mild-to-moderate UC in order to develop clinical algorithms that guide SDM to facilitate self-management. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530109DOI Listing
October 2018
1 Read

The risk for opportunistic infections in inflammatory bowel disease with biologics: an update.

Expert Rev Gastroenterol Hepatol 2018 Oct 2. Epub 2018 Oct 2.

a The Henry D. Janowitz Division of Gastroenterology , One Gustave L. Levy Place , New York , NY 10029 , USA.

Introduction: Crohn's disease and Ulcerative Colitis are forms of inflammatory bowel disease (IBD), chronic diseases treated with medical and surgical therapy. Patients with IBD are treated with potent immunomodulatory agents, leading to immunosuppression, and the potential for opportunistic infections. In 2014, the ECCO guidelines were released to guide the prevention, diagnosis and treatment of a variety of these opportunistic infections. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1530983DOI Listing
October 2018
4 Reads

Cutting-edge evidence of adjuvant treatments for gastric cancer.

Expert Rev Gastroenterol Hepatol 2018 Oct 1. Epub 2018 Oct 1.

b Tokai Central Hospital , 4-6-2 Sohara Higashijima-cho, Kakamigahara, Gifu 504-8601 , Japan.

Introduction: In recent decades, adjuvant therapy has secured a firm position in the treatment of gastric cancer by improving patient prognosis. Currently, standard therapy varies between East Asia, Europe and North America due to heterogeneities of the tumor, race, medical environment and/or surgical procedure. Although adjuvant strategies, proved effective in each region and implemented to clinical practice, certain patient populations with advanced gastric cancer show recurrence and a fatal prognosis. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530985DOI Listing
October 2018
7 Reads

Renal complications of liver diseases.

Expert Rev Gastroenterol Hepatol 2018 Oct 1. Epub 2018 Oct 1.

a Service de Néphrologie, Hémodialyse , Aphérèses et Transplantation rénale, Grenoble-Alpes , France.

Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the major causes of chronic liver disease. HBV and HCV affect nearly 7% of the world's population. Extra-hepatic complications and particularly renal failure have different mechanisms and manifestations. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530984DOI Listing
October 2018
12 Reads

Improvements in the management of chronic hepatitis B virus infection.

Expert Rev Gastroenterol Hepatol 2018 Sep 29:1-14. Epub 2018 Sep 29.

b Department of Medicine and Therapeutics and Institute of Digestive Disease , The Chinese University of Hong Kong , Hong Kong SAR , China.

Introduction: The primary goals of managing chronic hepatitis B (CHB) are prevention of liver-related complications and reduction of mortality. Universal vaccination has dramatically reduced the incidence of new infection, but the management of existing CHB patients are still challenging. Areas covered: This review compares the similarities and differences among the latest published regional guidelines on the indications and choices of antiviral therapy. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530986DOI Listing
September 2018
5 Reads

Intraductal papillary mucinous neoplasms of the pancreas: a clinical challenge.

Expert Rev Gastroenterol Hepatol 2018 Sep 28. Epub 2018 Sep 28.

a Division of Gastroenterology and Digestive Endoscopy , Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico , Milan , Italy.

Introduction: The incidental detection rate of intraductal papillary mucinous neoplasms (IPMNs) has significantly increased. However, little is known about the natural history of these tumors. Their optimal management and appropriate follow-up are still unclear. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530111DOI Listing
September 2018
6 Reads

An update on the recent advances in antifibrotic therapy.

Expert Rev Gastroenterol Hepatol 2018 Sep 27:1-10. Epub 2018 Sep 27.

b Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry , RWTH University Hospital Aachen , Aachen , Germany.

Introduction: Chronic injury to the liver, such as viral hepatitis, alcoholism, non-alcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH), promotes extracellular matrix deposition and organ scarring, termed hepatic fibrosis. Fibrosis might progress to cirrhosis and predisposes to hepatocellular carcinoma (HCC), but is also associated with extrahepatic morbidity and mortality in NAFLD/NASH. The improved understanding of pathogenic mechanisms underlying chronic inflammation and fibrogenesis in the liver prompted recent advances in antifibrotic therapies. Read More

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http://dx.doi.org/10.1080/17474124.2018.1530110DOI Listing
September 2018
13 Reads

Elobixibat for the Treatment of Constipation.

Expert Rev Gastroenterol Hepatol 2018 Sep 11. Epub 2018 Sep 11.

a Division of Gastroenterology and Hepatology , Mayo Clinic , 200 First St. S.W., Rochester , MN 55905.

Introduction: Chronic idiopathic constipation (CC) is highly prevalent worldwide. A subset of patients with CC have reduced fecal (and by inference, intra-colonic) bile acids (BA). Elobixibat, a locally-acting ileal bile acid transporter (IBAT) inhibitor, leads to increased BA delivery to the colon and represents a new class of treatment for CC. Read More

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http://dx.doi.org/10.1080/17474124.2018.1522248DOI Listing
September 2018
12 Reads

Primary sclerosing cholangitis in children versus adults: lessons for the clinic.

Expert Rev Gastroenterol Hepatol 2018 Sep 10:1-8. Epub 2018 Sep 10.

a Division of Gastroenterology and Hepatology , Mayo Clinic , Phoenix , AZ , USA.

Introduction: Primary sclerosing cholangitis (PSC) is a rare cholestatic disorder that presents with multifocal biliary strictures. PSC has a variable course but often leads to progressive liver disease, and most patients will eventually require liver transplantation. PSC has a strong association with inflammatory bowel disease and autoimmune liver disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1521719DOI Listing
September 2018
10 Reads

Multidrug-resistant bacterial infections in cirrhotic patients: an epidemiological study.

Expert Rev Gastroenterol Hepatol 2018 Sep 5:1-8. Epub 2018 Sep 5.

a State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine , Zhejiang University , Hangzhou , Zhejiang Province , China.

Background: The purpose of this study is to describe the epidemiological features of bacterial infections caused by multidrug-resistant (MDR) bacteria in cirrhotic patients and their impact on mortality.

Methods: A retrospective study of cirrhotic patients with culture-confirmed bacterial infections was performed between 2011 and 2017.

Results: A total of 635 episodes in 563 patients with cirrhosis were included. Read More

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http://dx.doi.org/10.1080/17474124.2018.1515627DOI Listing
September 2018
15 Reads

Microbial modulation of the gut microbiome for treating autoimmune diseases.

Expert Rev Gastroenterol Hepatol 2018 Sep 3:1-12. Epub 2018 Sep 3.

a Department of Immunology , Mayo Clinic , Rochester , MN , USA.

Introduction: Many studies have shown the relationship between autoimmune diseases and the gut microbiome in humans: those with autoimmune conditions display gut microbiome dysbiosis. The big question that needs to be addressed is if restoring eubiosis of the gut microbiota can help suppress the autoimmune condition by activating various immune regulatory mechanisms. Inducing these self-healing mechanisms should prolong good health in affected individuals. Read More

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http://dx.doi.org/10.1080/17474124.2018.1517044DOI Listing
September 2018
12 Reads

Hepatic resection for elderly patients with hepatocellular carcinoma: a systematic review of more than 17,000 patients.

Expert Rev Gastroenterol Hepatol 2018 Sep 5:1-10. Epub 2018 Sep 5.

a Hepatobiliary Surgery Department , Affiliated Tumor Hospital of Guangxi Medical University , Nanning , China.

Background: With the aging population and increasing incidence of hepatic malignancies in elderly patients, establishing the safety and efficacy of hepatic resection for elderly patients with hepatocellular carcinoma (HCC) is crucial. The present systematic review investigates postoperative morbidity, hospital mortality, median survival time, overall and disease-free survival in elderly patients with undergoing hepatic resection.

Methods: Some databases were systematically searched for prospective or retrospective studies to reveal the safety and efficacy of hepatic resection for elderly patients with primary HCC. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1517045DOI Listing
September 2018
10 Reads

An update on dietary consideration in inflammatory bowel disease: anthocyanins and more.

Expert Rev Gastroenterol Hepatol 2018 Sep 26:1-18. Epub 2018 Sep 26.

k Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.

Introduction: Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder. A wealth of data pointed out that various aspects of chronic inflammation may be affected by several specific dietary factors. This paper calls attention to anthocyanins enriched plant food and anthocyanin dietary supplements, whose role in the management of IBD and its associated oncogenesis deems crucial. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1513322DOI Listing
September 2018
18 Reads
2.550 Impact Factor

The role of genetics in Crohn's disease: how could it influence future therapies?

Expert Rev Gastroenterol Hepatol 2018 Aug 21:1-3. Epub 2018 Aug 21.

a Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/17474124.2018.1513323DOI Listing
August 2018
2 Reads

Testing for AFP in combination with ultrasound improves early liver cancer detection.

Expert Rev Gastroenterol Hepatol 2018 Aug 21:1-3. Epub 2018 Aug 21.

a Department of Internal Medicine , UT Southwestern Medical Center , Dallas , TX , USA.

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http://dx.doi.org/10.1080/17474124.2018.1512855DOI Listing
August 2018
1 Read

Unmet needs in pediatric NAFLD research: what do we need to prioritize for the future?

Expert Rev Gastroenterol Hepatol 2018 Aug 21:1-7. Epub 2018 Aug 21.

d Metabolic Research Laboratories, Institute of Metabolic Science , University of Cambridge , Cambridge , UK.

Introduction: Pediatric nonalcoholic fatty liver disease (NAFLD) is common disorder that has complex pathophysiology and unquantified clinical significance. Though there have been major advances in the field, there is much yet to be understood. Areas covered: PubMed/MEDLINE and Embase were searched for articles related to pediatric NAFLD and nonalcoholic steatohepatitis (NASH) between January 1998 and January 2018. Read More

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http://dx.doi.org/10.1080/17474124.2018.1512853DOI Listing

Interactions of helminths with macrophages: therapeutic potential for inflammatory intestinal disease.

Expert Rev Gastroenterol Hepatol 2018 Aug 16:1-10. Epub 2018 Aug 16.

a Faculty of Biology, Medicine and Health , University of Manchester , Manchester , UK.

Introduction: Macrophages represent a highly heterogeneous and plastic cell type found in most tissues of the body; the intestine is home to enormous numbers of these cells. Considerable interest surrounds the 'M2 macrophage,' as it is able to control and regulate inflammation, while promoting tissue repair. Areas covered: As potent inducers of M2 macrophages, intestinal helminths and helminth-derived products are ideal candidates for small molecule drug design to drive M2 macrophage polarization. Read More

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http://dx.doi.org/10.1080/17474124.2018.1505498DOI Listing

Latest advances in diagnosing and predicting DILI: what was new in 2017?

Expert Rev Gastroenterol Hepatol 2018 Sep 3:1-11. Epub 2018 Sep 3.

b Department of Gastroenterology , Medstar Georgetown University Hospital , Washington , DC , USA.

Introduction: Drug-induced liver injury (DILI) remains an increasingly recognized cause of hepatotoxicity and liver failure worldwide. In 2017, we continued to learn about predicting, diagnosing, and prognosticating drug hepatotoxicity. Areas covered: In this review, we selected from over 1200 articles from 2017 to synopsize updates in DILI. Read More

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http://dx.doi.org/10.1080/17474124.2018.1512854DOI Listing
September 2018
17 Reads

Urban-rural environmental exposure during childhood and subsequent risk of inflammatory bowel disease: a meta-analysis.

Expert Rev Gastroenterol Hepatol 2018 Aug 28:1-12. Epub 2018 Aug 28.

a Department of Gastroenterology , the First Affiliated Hospital of Nanchang University , Nanchang , China.

Background: The relationship between living conditions in urban and rural areas during childhood and subsequent inflammatory bowel disease (IBD) remains controversial.

Aim: To explore the association between environmental exposures early in life and the subsequent risk of IBD.

Methods: Literature searches were conducted in the following databases: PubMed, EMBASE, and Conference Proceedings Citation Index. Read More

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http://dx.doi.org/10.1080/17474124.2018.1511425DOI Listing

Impact of Time to Start Systemic Therapy on the Outcomes of Patients with Metastatic Colorectal Cancer Treated with First Line FOLFOX Chemotherapy; a Patient-Level Pooled Analysis of Two Clinical Trials.

Expert Rev Gastroenterol Hepatol 2018 Aug 20:1-6. Epub 2018 Aug 20.

d Clinical Oncology department, faculty of medicine , Ain shams university , Cairo , Egypt.

Background: Impact of time to start first-line systemic chemotherapy following diagnosis of metastatic colorectal cancer (mCRC) needs to be studied.

Methods: This is a pooled analysis of the raw data of the comparator arms of two randomized studies (NCT00272051; NCT00305188). Univariate and multivariate analyses of predictors of overall and progression-free survival were conducted through Cox regression analysis. Read More

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http://dx.doi.org/10.1080/17474124.2018.1511426DOI Listing
August 2018
1 Read
2.550 Impact Factor

Epidemiology, disease burden, and treatment challenges of ulcerative colitis in Africa and the Middle East.

Expert Rev Gastroenterol Hepatol 2018 Sep 10;12(9):883-897. Epub 2018 Aug 10.

h Department of Medicine , King Abdulaziz University , Jeddah , Kingdom of Saudi Arabia.

Introduction: Ulcerative colitis is an idiopathic, chronic, inflammatory bowel disorder characterized by an unpredictable course of alternating cycles of relapse and remission. Traditionally viewed as a disease of Western countries, the prevalence of ulcerative colitis is reported to be increasing in the developing world. In these regions, there is the potential to further explore the etiology of the disease, mainly through genetic studies. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1503052DOI Listing
September 2018
19 Reads

Normothermic ex-vivo liver perfusion: where do we stand and where to reach?

Expert Rev Gastroenterol Hepatol 2018 Aug 20:1-14. Epub 2018 Aug 20.

b Department of Surgery , University of Alberta , Edmonton , Canada.

Introduction: Nowadays liver transplantation is considered as the treatment of choice, however, the scarcity of suitable donor organs limits the delivery of care to the end-stage liver disease patients leading to the death while on the waiting list. The advent of ex-situ normothermic machine perfusion (NMP) has emerged as an alternative to the standard organ preservation technique, static cold storage (SCS). The newer technique promises to not only restore the normal metabolic activity but also attempt to recondition the marginal livers back to the pristine state, which are otherwise more susceptible to ischemic injury and foster the poor post-transplant outcomes. Read More

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http://dx.doi.org/10.1080/17474124.2018.1505499DOI Listing

An update on the role of gut microbiota in chronic inflammatory diseases, and potential therapeutic targets.

Expert Rev Gastroenterol Hepatol 2018 Aug 1:1-15. Epub 2018 Aug 1.

a Discipline of Nutrition and Dietetics, Faculty of Medical Health Sciences , The University of Auckland , Auckland , New Zealand.

Introduction: The human microbiome plays a critical role in human health, having metabolic, protective, and trophic functions, depending upon its' exact composition. This composition is affected by a number of factors, including the genetic background of the individual, early life factors (including method of birth, length of breastfeeding) and nature of the diet and other environmental exposures (including cigarette smoking) and general life habits. It plays a key role in the control of inflammation, and in turn, its' composition is significantly influenced by inflammation. Read More

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http://dx.doi.org/10.1080/17474124.2018.1505497DOI Listing
August 2018
1 Read

Considering gut microbiota disturbance in the management of Helicobacter pylori infection.

Expert Rev Gastroenterol Hepatol 2018 Sep 7;12(9):899-906. Epub 2018 Aug 7.

a Internal Medicine, Gastroenterology and Hepatology Department , Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore , Roma , Italy.

Introduction: Helicobacter pylori (Hp) infection produces drastic changes in the gastric microenvironment, which, in turn, influence the gastric microbiota composition and might be correlated with large intestinal microbiota changes. This excellent perturbing actor could trigger important modifications in the homeostatic functions exerted by gut commensals leading to a new gastrointestinal balance. At the same time, the therapeutic strategies used to eradicate Hp can modulate this physiological symbiosis, but can be also conversely affected by its properties. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1503946DOI Listing
September 2018
4 Reads

Health benefits of Mediterranean diet in nonalcoholic fatty liver disease.

Expert Rev Gastroenterol Hepatol 2018 Sep 1;12(9):873-881. Epub 2018 Aug 1.

b Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Insulin resistance and obesity-related inflammatory status, associated with genetic, dietary, and lifestyle factors, are involved in its pathogenesis. There is no consensus concerning the pharmacological treatment of NAFLD. Read More

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http://dx.doi.org/10.1080/17474124.2018.1503947DOI Listing
September 2018
2 Reads

An overview of angiodysplasia: management and patient prospects.

Expert Rev Gastroenterol Hepatol 2018 Sep 3;12(9):863-872. Epub 2018 Aug 3.

a Department of Gastroenterology and Clinical Medicine , Trinity Centre for Health Sciences' Tallaght Hospital , Dublin , Ireland.

Introduction: Gastrointestinal angiodysplasias (GIADs) have a wide variety of presentations, which can be significant and debilitating in a subset of patients. Endoscopic ablation is currently the most effective treatment for GIADs, however re-bleeding rates are high. Several medical have been used for GIADs and reported in the literature, however these medications have significant side effect profiles and randomized controlled trials are lacking. Read More

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http://dx.doi.org/10.1080/17474124.2018.1503532DOI Listing
September 2018
2 Reads

Comparative efficacy and safety between ablative therapies or surgery for small hepatocellular carcinoma: a network meta-analysis.

Expert Rev Gastroenterol Hepatol 2018 Sep 25;12(9):935-945. Epub 2018 Jul 25.

a Liver Cancer Institute, Zhongshan Hospital , Fudan University , Shanghai , China.

Background: Major treatments for small hepatocellular carcinoma (SHCC) include percutaneous ethanol injection (PEI), percutaneous acetic acid injection (PAI), radiofrequency ablation (RFA), or surgical resection (SR). We aimed to compare these therapies concerning with effectiveness and safety.

Methods: Cochrane Library, PubMed, and Embase were searched for randomized controlled studies (RCTs) from inception to 30 April 2017. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1503531DOI Listing
September 2018
7 Reads

Advances in understanding the role of cytokines in inflammatory bowel disease.

Expert Rev Gastroenterol Hepatol 2018 Sep 30;12(9):907-915. Epub 2018 Jul 30.

a Department of Systems Medicine , University of Rome Tor Vergata , Italy.

Introduction: Cytokines represent the key pathophysiologic elements that govern the initiation, progression, and, in some circumstances, the resolution of the inflammation occurring in inflammatory bowel disease (IBD). Areas covered: In this review, we will focus on the main effector and anti-inflammatory cytokines produced in IBD and discuss the results of recent trials in which cytokine-based therapy has been used for treating IBD patients. Expert commentary: The possibility to sample mucosal biopsies from IBD patients and analyze which molecular pathways are prominent during the active phases of the disease and the easy access to various models of experimental colitis has largely advanced our understanding about the role of cytokines in IBD. Read More

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http://dx.doi.org/10.1080/17474124.2018.1503053DOI Listing
September 2018
12 Reads

Gastrointestinal pathophysiology and nutrition in cystic fibrosis.

Expert Rev Gastroenterol Hepatol 2018 Sep 3;12(9):853-862. Epub 2018 Aug 3.

a Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition , Saint Louis University School of Medicine , Saint Louis , Missouri , USA.

Introduction: Cystic fibrosis (CF) is a severe, progressive, multisystemic disease that is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene. Optimizing nutrition is critical, as higher growth parameters are associated with better pulmonary function and outcomes, but unfortunately patients with this disease are prone to malnutrition, growth failure, and vitamin deficiencies. The purpose of this review is to provide a timely highlight of the physiologic processes and outcome data to support today's management strategies, as well as review these principles themselves. Read More

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http://dx.doi.org/10.1080/17474124.2018.1502663DOI Listing
September 2018
1 Read

Erratum.

Authors:

Expert Rev Gastroenterol Hepatol 2018 Aug 17;12(8):ix. Epub 2018 Jul 17.

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http://dx.doi.org/10.1080/17474124.2018.1500981DOI Listing

ABO blood type and risk of hepatocellular carcinoma: a meta-analysis.

Expert Rev Gastroenterol Hepatol 2018 Sep 26;12(9):927-933. Epub 2018 Jul 26.

a Meta-analysis Interest Group, General Hospital of Shenyang Military Area , Shenyang , Liaoning Province , China.

Background: ABO blood type is an invariant factor. There is a link between ABO blood type and some malignancies, such as gastric, pancreatic, and skin cancer. The role of ABO blood type in the pathogenesis of hepatocellular carcinoma (HCC) remains controversial. Read More

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http://dx.doi.org/10.1080/17474124.2018.1500174DOI Listing
September 2018
6 Reads

Fistula-associated anal carcinoma in Crohn's disease.

Expert Rev Gastroenterol Hepatol 2018 Sep 24;12(9):917-925. Epub 2018 Jul 24.

c Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology , University of Calgary , Calgary , Canada.

Introduction: Fistula-associated anal carcinoma in patients with Crohn's disease (CD) is a rare condition. More recently, this entity has been increasingly reported likely due to increased recognition, and the incidence may be greater than once appreciated. There remains a paucity of data regarding the incidence, diagnosis, treatment, and outcome of fistula-associated anal carcinoma. Read More

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http://dx.doi.org/10.1080/17474124.2018.1500175DOI Listing
September 2018
21 Reads

The role of the chronic care model in promoting the management of the patient with rare liver disease.

Expert Rev Gastroenterol Hepatol 2018 Aug 13;12(8):829-841. Epub 2018 Jul 13.

b Department of Clinical and experimental medicine , University of Surrey , Guildford , UK.

Introduction: The chronic care model (CCM) provides a holistic approach for managing chronic illnesses. Patients with rare liver diseases (RLD) have complex needs, impaired quality of life and often life-threatening complications. Most RLD meet the criteria for a long-term chronic condition and should be viewed through the prism of CCM. Read More

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http://dx.doi.org/10.1080/17474124.2018.1497483DOI Listing
August 2018
17 Reads
2.550 Impact Factor

Helicobacter pylori drug resistance: therapy changes and challenges.

Expert Rev Gastroenterol Hepatol 2018 Aug 13;12(8):819-827. Epub 2018 Jul 13.

a Hospital Universitario Dr. José Eleuterio González y Facultad de Medicina, Servicio de Gastroenterología,Nuevo León , Universidad Autónoma de Nuevo León , Monterrey , México.

Introduction: Helicobacter pylori is a Gram-negative bacterium that causes chronic gastritis, dyspepsia, peptic ulcers, and gastric cancer. Over half the world's population is infected with H. pylori, with higher prevalence in developing countries. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1496017DOI Listing
August 2018
10 Reads

Pregnant women with inflammatory bowel disease: the effects of biologicals on pregnancy, outcome of infants, and the developing immune system.

Expert Rev Gastroenterol Hepatol 2018 Aug 12;12(8):811-818. Epub 2018 Jul 12.

d Department of Gastroenterology , Erasmus Medical Center , Rotterdam , The Netherlands.

Introduction: Relapse of inflammatory bowel disease (IBD) during conception and pregnancy has been associated with a negative pregnancy outcome. Therefore, it is advised to maintain drugs in order to prevent relapse. The effect of drugs, which cross the placenta, on children who have been exposed during pregnancy will be discussed in this review. Read More

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http://dx.doi.org/10.1080/17474124.2018.1496820DOI Listing
August 2018
22 Reads

Pancreas volume in health and disease: a systematic review and meta-analysis.

Expert Rev Gastroenterol Hepatol 2018 Aug 16;12(8):757-766. Epub 2018 Jul 16.

a School of Medicine , University of Auckland , Auckland , New Zealand.

Introduction: The pancreas plays a central role in metabolism and is involved in the pathogenesis of several diseases. Pancreas volume is a holistic quantitative measure of pancreas size but the clinical relevance of pancreas volumetry is poorly understood. Areas covered: The aim was to systematically review studies in adults that used computed tomography or magnetic resonance imaging to measure pancreas volume in health and disease, to determine normal pancreas volume range, and to quantify changes in pancreas volume that are associated with disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1496015DOI Listing
August 2018
6 Reads

Impact of primary tumor side on the outcomes of patients with non-metastatic colon cancer; a patient-level pooled analysis of two clinical trials.

Expert Rev Gastroenterol Hepatol 2018 Aug 10;12(8):843-848. Epub 2018 Jul 10.

d Clinical Oncology department, faculty of medicine , Ain shams university , Cairo , Egypt.

Objective: To assess the impact of primary tumor side on the outcomes of non-metastatic colon cancer patients included in two clinical trials.

Methods: Overall and disease-free survivals were assessed according to the side of the tumor, through Kaplan-Meier analysis. Univariate and Multivariate analysis of predictors of disease-free survival was performed through Cox regression analysis. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1495075DOI Listing
August 2018
10 Reads
2.550 Impact Factor

Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI.

Expert Rev Gastroenterol Hepatol 2018 Aug 19;12(8):767-778. Epub 2018 Jul 19.

d Department of Digestive Diseases and Hepatology , Mount Sinai Beth Israel , New York , NY , USA.

Introduction: Hereditary hemochromatosis (HH) is an autosomal recessive disorder that occurs in approximately 1 in 200-250 individuals. Mutations in the HFE gene lead to excess iron absorption. Excess iron in the form of non-transferrin-bound iron (NTBI) causes injury and is readily uptaken by cardiomyocytes, pancreatic islet cells, and hepatocytes. Read More

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http://dx.doi.org/10.1080/17474124.2018.1496016DOI Listing
August 2018
4 Reads

How to predict response to anti-tumour necrosis factor agents in inflammatory bowel disease.

Expert Rev Gastroenterol Hepatol 2018 Aug 6;12(8):797-810. Epub 2018 Jul 6.

c First Department of Internal Medicine, San Matteo Hospital Foundation , University of Pavia , Pavia , Italy.

Introduction: Anti-tumor necrosis factor (TNF) agents have changed the therapeutic approach to inflammatory bowel disease (IBD). However, a considerable proportion of patients either do not primarily respond or lose response to treatment. Despite the long-standing experience in the use of these drugs, still there is the need of identifying the possible predictors of efficacy. Read More

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http://dx.doi.org/10.1080/17474124.2018.1494573DOI Listing
August 2018
2.550 Impact Factor

Treating pancreatic cancer: more antioxidants more problems?

Expert Rev Gastroenterol Hepatol 2018 Sep 5;12(9):849-851. Epub 2018 Jul 5.

a Departments of Surgery and Radiation Oncology, Holden Comprehensive Cancer Center , The University of Iowa Hospitals and Clinics and the University of Iowa College of Medicine , Iowa City , IA , USA.

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http://dx.doi.org/10.1080/17474124.2018.1494572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317716PMC
September 2018

The role of imaging and biopsy in the management and staging of large non-pedunculated rectal polyps.

Expert Rev Gastroenterol Hepatol 2018 Aug 4;12(8):749-755. Epub 2018 Jul 4.

c Department of Gastroenterology , Queen Alexandra Hospital , Portsmouth , UK.

Introduction: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are often used for benign and Sm1 large non-pedunculated rectal polyps (LNPRPs), although other surgical techniques including transanal endoscopic microsurgery (TEMS) and transanal minimal invasive surgery remain available. This review covers the role of pre-excisional imaging and selective biopsy of LNPRPs. Areas covered: Polyps between 2 and 3 cm with favorable features (Paris 1, Kudo III/IV pit patterns, and non-lateral spreading type [LST]) may have a one-stage EMR without biopsy and imaging, provided adequate expertise is available with other technologies such as magnifying chromoendoscopy. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1492377DOI Listing
August 2018
11 Reads
2.550 Impact Factor

Somatostatin analogue-induced pancreatic exocrine insufficiency in patients with neuroendocrine tumors: results of a prospective observational study.

Expert Rev Gastroenterol Hepatol 2018 Jul 28;12(7):723-731. Epub 2018 Jun 28.

a Department of Medical Oncology , European Neuroendocrine Tumour Society (ENETS) Centre of Excellence, The Christie NHS Foundation Trust , Manchester , UK.

Background: Patients with advanced well-differentiated neuroendocrine tumours (Wd-NETs) are commonly treated with somatostatin analogues (SSAs). Some patients may develop SSA-related side effects such as pancreatic exocrine insufficiency (PEI).

Methods: In this prospective, observational study, the frequency of SSA-induced PEI in 50 sequential patients with advanced Wd-NETs treated with SSAs was investigated. Read More

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http://dx.doi.org/10.1080/17474124.2018.1489232DOI Listing
July 2018
33 Reads

Updates in the field of autoimmune pancreatitis: a clinical guide.

Expert Rev Gastroenterol Hepatol 2018 Jul 26;12(7):705-709. Epub 2018 Jun 26.

a Department of Medicine, Pancreas Institute , University of Verona , Verona , Italy.

Introduction: Autoimmune Pancreatitis (AIP) is a peculiar form of pancreatitis different from all other type of pancreatitis ('one like no one pancreatitis') and characterized by a dramatic response to steroids. AIP can be classified histologically in type 1, included in a larger group of diseases named IgG4-related disease, and type 2. At imaging, AIP may involve all (diffuse form) or only a part (focal form) of the pancreatic gland. Read More

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http://dx.doi.org/10.1080/17474124.2018.1489230DOI Listing

Challenges of surgical management of intrahepatic cholangiocarcinoma.

Expert Rev Gastroenterol Hepatol 2018 Jul 27;12(7):671-681. Epub 2018 Jun 27.

a Division of Surgical Oncology, Department of Surgery , The Ohio State University Wexner Medical Center , Columbus , OH , USA.

Introduction: Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy arising from biliary tract epithelium within bile ducts proximal to the secondary biliary radicles. The majority of patients are diagnosed with locally advanced or metastatic disease at presentation. Surgical resection remains the only potentially curative option, but poses unique challenges due to the large size and aggressive behavior of these tumors. Read More

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http://dx.doi.org/10.1080/17474124.2018.1489229DOI Listing
July 2018
12 Reads

Outcomes and prediction of corticosteroid therapy after successive courses of ulcerative colitis treatments.

Expert Rev Gastroenterol Hepatol 2018 Jul 27;12(7):733-741. Epub 2018 Jun 27.

b Farmacología, Departamento de Medicina , Universidad de Oviedo; Instituto Universitario de Oncología del Principado de Asturias (IUOPA) , Oviedo , Spain.

Background: Ulcerative colitis (UC) may require systemic corticosteroid (CS) treatment often without a reliable predictable response, except the Ho-index, used to predict severe cases. The present study aims to determine CS-efficacy and CS-free remission for different courses and longer follow-ups, and a predictive value of CS-outcomes, by the Ho-index and the analysis of clinical variables.

Methods: An observational retrospective study performed with 136 patients was based on clinical and analytical characteristics, before successive CS-therapies. Read More

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http://dx.doi.org/10.1080/17474124.2018.1489231DOI Listing

Review of recent efforts to discover biomarkers for early detection, monitoring, prognosis, and prediction of treatment responses of patients with gastric cancer.

Expert Rev Gastroenterol Hepatol 2018 Jul 25;12(7):657-670. Epub 2018 Jun 25.

a Department of Gastroenterological Surgery (Surgery II) , Nagoya University Graduate School of Medicine , Nagoya , Japan.

Introduction: Gastric cancer (GC) is the leading cause of cancer-related death worldwide. Despite recent advances in diagnosis and therapy, the prognosis of patients with GC is poor. Many patients have inoperable disease upon diagnosis or experience recurrent disease after curative gastrectomy. Read More

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http://dx.doi.org/10.1080/17474124.2018.1489233DOI Listing
July 2018
18 Reads

A critical appraisal of advances in the diagnosis of diverticular disease.

Authors:
Antonio Tursi

Expert Rev Gastroenterol Hepatol 2018 Aug 19;12(8):791-796. Epub 2018 Jun 19.

a Gastroenterology Service , ASL BAT , Andria , Italy.

Introduction: Diverticulosis of the colon is a common condition, and about one-fourth of those people develop symptoms, which is called 'diverticular disease' (DD). Since there are still some concerns about the diagnosis of DD, the aim of this review was to analyze current and evolving advances in its diagnosis. Area covered: Analysis of clinical, radiology, laboratory, and endoscopic tools to pose a correct diagnosis of DD was performed according to current PubMed literature. Read More

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http://dx.doi.org/10.1080/17474124.2018.1487288DOI Listing

Capsule endoscopy for patients with coeliac disease.

Expert Rev Gastroenterol Hepatol 2018 Aug 19;12(8):779-790. Epub 2018 Jun 19.

a Gastroenterology Department , Sheffield Teaching Hospitals , Sheffield , UK.

Introduction: Coeliac disease is an autoimmune mediated condition in response to gluten. A combination of innate and adaptive immune responses results in villous shortening in the small bowel (SB) that can be morphologically picked up on capsule endoscopy. It is the only imaging modality that can provide mucosal views of the entire SB, while histology is generally limited to the proximal SB. Read More

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http://dx.doi.org/10.1080/17474124.2018.1487289DOI Listing
August 2018
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Endoscopic management of primary sclerosing cholangitis.

Expert Rev Gastroenterol Hepatol 2018 Jul 18;12(7):693-703. Epub 2018 Jun 18.

b Division of Gastroenterology and Hepatology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.

Introduction: Primary sclerosing cholangitis (PSC) is a rare but clinically important cholestatic liver disease. Histopathologically and cholangiographically, PSC is characterized by intra- and/or extra-hepatic bile duct inflammation and fibro-obliteration, which ultimately leads to biliary cirrhosis and related sequelae, including development of hepatobiliary and colorectal carcinomata. PSC can be diagnosed at essentially any age and carries a median survival of 15-20 years, regardless of age at diagnosis, and is a foremost risk factor for cholangiocarcinoma. Read More

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http://dx.doi.org/10.1080/17474124.2018.1483719DOI Listing
July 2018
2 Reads

Pathophysiology of diverticular disease.

Expert Rev Gastroenterol Hepatol 2018 Jul 7;12(7):683-692. Epub 2018 Jun 7.

a Department of Surgery, Division of Colon and Rectal Surgery , The Pennsylvania State University, College of Medicine , Hershey , PA , USA.

Introduction: Inflammation of diverticula, or outpouchings of the colonic mucosa and submucosa through the muscularis layer, leads to diverticulitis. The development of diverticular disease, encompassing both diverticulosis and diverticulitis, is a result of genetic predisposition, lifestyle, and environmental factors, including the microbiome. Areas covered: Previous reports implicated genetic predisposition, environmental factors, and colonic dysmotility in diverticular disease. Read More

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http://dx.doi.org/10.1080/17474124.2018.1481746DOI Listing
July 2018
1 Read