790 results match your criteria Expert Review of Endocrinology & Metabolism [Journal]


[Immunotherapy-induced endocrinopathies: Insights from the 2018 French Endocrine Society Guidelines].

Bull Cancer 2019 Apr 10. Epub 2019 Apr 10.

Hospices Civils de Lyon, Fédération d'endocrinologie, université Claude Bernard Lyon 1, HESPER EA 7425, 69008 Lyon, France.

The management of cancer patients has changed due to the considerably more frequent use of immune checkpoint inhibitors (ICPI). However, the use of ICPI has a risk of side-effects, particularly endocrine toxicity. Since the indications for ICPI are constantly expanding due to their efficacy, it is important that endocrinologists and oncologists know how to look for this type of toxicity and how to treat it when it arises. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.02.003DOI Listing

Assessment of Muscle Function and Physical Performance in Daily Clinical Practice : A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Calcif Tissue Int 2019 Apr 10. Epub 2019 Apr 10.

Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA.

It is well recognized that poor muscle function and poor physical performance are strong predictors of clinically relevant adverse events in older people. Given the large number of approaches to measure muscle function and physical performance, clinicians often struggle to choose a tool that is appropriate and validated for the population of older people they deal with. In this paper, an overview of different methods available and applicable in clinical settings is proposed. Read More

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http://link.springer.com/10.1007/s00223-019-00545-w
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http://dx.doi.org/10.1007/s00223-019-00545-wDOI Listing
April 2019
2 Reads

Current and emerging osteoporosis pharmacotherapy for women: state of the art therapies for preventing bone loss.

Expert Opin Pharmacother 2019 Apr 8:1-12. Epub 2019 Apr 8.

c Academic Orthopaedic Unit , Aristotle University Medical School, Papageorgiou General Hospital , Thessaloniki , Greece.

Introduction: Pharmacological options to address the imbalance between bone resorption and accrual in osteoporosis include anti-resorptive and osteoanabolic agents. Unique biologic pathways such as the Wnt/β-catenin pathway have been targeted in the quest for new emerging therapeutic strategies. Areas covered: This review provides an overview of existing pharmacotherapy for osteoporosis in women and explore state-of-the-art and emerging therapies to prevent bone loss, with an emphasis on the mechanism of action, indications and side effects. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1
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http://dx.doi.org/10.1080/14656566.2019.1594772DOI Listing
April 2019
5 Reads

Hypophysitis in the era of immune checkpoint inhibitors and immunoglobulin G4-related disease.

Expert Rev Endocrinol Metab 2019 Mar 27:1-12. Epub 2019 Mar 27.

a Division of Endocrinology, Diabetes and Metabolism, and Pituitary Center , The Johns Hopkins University Hospital , Baltimore , MD , USA.

Introduction: Hypophysitis is a rare disorder, defined as inflammation of the pituitary gland that may result in pituitary enlargement and varying anterior and posterior pituitary hormonal deficits. It involves different histopathological subtypes and variable etiologies, with considerable overlap between classification systems. Histopathology is the gold standard diagnostic approach. Read More

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http://dx.doi.org/10.1080/17446651.2019.1598260DOI Listing
March 2019
1 Read

Examining Development Processes for Text Messaging Interventions to Prevent Cardiovascular Disease: Systematic Literature Review.

JMIR Mhealth Uhealth 2019 Mar 29;7(3):e12191. Epub 2019 Mar 29.

Radcliffe Observatory Quarter, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Background: Interventions delivered by mobile phones have the potential to prevent cardiovascular disease (CVD) by supporting behavior change toward healthier lifestyles and treatment adherence. To allow replication and adaptation of these interventions across settings, it is important to fully understand how they have been developed. However, the development processes of these interventions have not previously been systematically examined. Read More

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http://dx.doi.org/10.2196/12191DOI Listing

Medical Treatment with Somatostatin Analogues in Acromegaly: Position Statement.

Endocrinol Metab (Seoul) 2019 Mar;34(1):53-62

Division of Endocrinology and Metabolism, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.

The Korean Endocrine Society (KES) published clinical practice guidelines for the treatment of acromegaly in 2011. Since then, the number of acromegaly cases, publications on studies addressing medical treatment of acromegaly, and demands for improvements in insurance coverage have been dramatically increasing. In 2017, the KES Committee of Health Insurance decided to publish a position statement regarding the use of somatostatin analogues in acromegaly. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3803/EnM.2019.34
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http://dx.doi.org/10.3803/EnM.2019.34.1.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435847PMC
March 2019
4 Reads

Familial hypercholesterolemia in China half a century: A review of published literature.

Atheroscler Suppl 2019 Mar 29;36:12-18. Epub 2019 Jan 29.

Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases Beijing, 100029, China; Department of Atherosclerosis, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. Electronic address:

Aims: To investigate the status of familial hypercholesterolemia (FH) research and the characteristics of patients with FH in China.

Methods: Published papers in Chinese or English language from PubMed, SinoMed and CNKI databases from 1971 to March 2018 were searched using 'Familial hypercholesterolemia', 'Chinese' and 'Han' as keywords. A systematic review of studies on familial hypercholesterolemia was then conducted. Read More

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http://dx.doi.org/10.1016/j.atherosclerosissup.2019.01.003DOI Listing
March 2019
1 Read

Establishing the Link Between Lean Mass and Grip Strength Cut-points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference.

J Gerontol A Biol Sci Med Sci 2019 Mar 14. Epub 2019 Mar 14.

Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Lack of consensus on how to diagnose sarcopenia has limited the ability to diagnose this condition and hindered drug development. The Sarcopenia Definitions and Outcomes Consortium (SDOC) was formed to develop evidence-based diagnostic cut-points for lean mass and/or muscle strength that identify people at increased risk of mobility disability. We describe here the proceedings of a meeting of SDOC and other experts to discuss strategic considerations in the development of evidence-based sarcopenia definition. Read More

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http://dx.doi.org/10.1093/gerona/glz081DOI Listing
March 2019
3 Reads

Safety of red yeast rice supplementation: A systematic review and meta-analysis of randomized controlled trials.

Pharmacol Res 2019 Mar 4;143:1-16. Epub 2019 Mar 4.

Department of Medicine and Surgery Sciences, University of Bologna, Bologna, Italy. Electronic address:

Recently, concerns regarding the safety of red yeast rice (RYR) have been raised after the publication of some case reports claiming toxicity. Since the previous meta-analyses on the effects of RYR were mainly focused on its efficacy to improve lipid profile and other cardiovascular parameters, we carried out a meta-analysis on safety data derived from the available randomized controlled clinical trials (RCTs). Primary outcomes were musculoskeletal disorders (MuD). Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.028DOI Listing
March 2019
10 Reads

Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.

Expert Opin Drug Metab Toxicol 2019 Apr 18;15(4):329-339. Epub 2019 Mar 18.

a Center for Pharmacogenetics and Department of Pharmaceutical Sciences , University of Pittsburgh , Pittsburgh , PA , USA.

Introduction: Biotransformation is important in the metabolism of endobiotics and xenobiotics. This process comprises the activity of phase I and phase II enzymes. Estrogen sulfotransferase (SULT1E1 or EST) is a phase II conjugating enzyme that belongs to the family of cytosolic sulfotransferases. Read More

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http://dx.doi.org/10.1080/17425255.2019.1588884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428602PMC
April 2019
3 Reads

Heart failure hospitalization with SGLT-2 inhibitors: a systematic review and meta-analysis of randomized controlled and observational studies.

Expert Rev Clin Pharmacol 2019 Apr 11;12(4):299-308. Epub 2019 Mar 11.

b Department of Gynecology & Obstetrics , GD Hospital & Diabetes Institute , Kolkata , India.

Introduction: Heart failure (HF) in type 2 diabetes mellitus (T2DM) poses a significant increase in mortality. Until recently, anti-diabetic drugs have not been shown to reduce hospitalization due to heart failure (hHF). While thiazolidinedione class and saxagliptin has shown a significantly increased risk, sodium-glucose linked co-transporter 2 inhibitors (SGLT-2Is) have demonstrated a significant reduction in the risk of hHF. Read More

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http://dx.doi.org/10.1080/17512433.2019.1588110DOI Listing
April 2019
12 Reads

EADSG Guidelines: Insulin Storage and Optimisation of Injection Technique in Diabetes Management.

Diabetes Ther 2019 Apr 27;10(2):341-366. Epub 2019 Feb 27.

Department of Internal Medicine, Rwanda Military Hospital, Kigali, Rwanda.

To date, insulin therapy remains the cornerstone of diabetes management; but the art of injecting insulin is still poorly understood in many health facilities. To address this gap, the Forum for Injection Technique and Therapy Expert Recommendations (FITTER) published recommendations on injection technique after a workshop held in Rome, Italy in 2015. These recommendations are generally applicable to the majority of patients on insulin therapy, athough they do not explore alternative details that may be suitable for low- and middle-income countries. Read More

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http://dx.doi.org/10.1007/s13300-019-0574-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437255PMC
April 2019
5 Reads

Revefenacin for the treatment of chronic obstructive pulmonary disease.

Expert Rev Clin Pharmacol 2019 Apr 22;12(4):293-298. Epub 2019 Mar 22.

b Department of Pharmaceutical , Central Hospital of Linyi City , Yishui , Shandong , China.

Introduction: Acetylcholine is the predominant parasympathetic neurotransmitter in the airways, and plays a key role in the pathophysiology of chronic obstructive pulmonary disease (COPD). Muscarinic receptors are found in smooth muscle cells and submucosal glands. Binding of acetylcholine to muscarinic receptors could trigger bronchoconstriction. Read More

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http://dx.doi.org/10.1080/17512433.2019.1587292DOI Listing
April 2019
12 Reads

Update on central precocious puberty: from etiologies to outcomes.

Expert Rev Endocrinol Metab 2019 03 12;14(2):123-130. Epub 2019 Feb 12.

b Department of Pediatrics/Division of Pediatric Endocrinology and Diabetology , Riley Hospital for Children, Indiana University School of Medicine , Indianapolis , IN , USA.

Introduction: Precocious puberty (PP) is one of the most common reasons for referral to pediatric endocrinologists. Gonadotropin-releasing hormone analogs (GnRHas) are the gold standard for the treatment of central precocious puberty (CPP) and have an impressive record of safety and efficacy. However, ongoing refinements in diagnosis and management continue to lead to important advancements in clinical care. Read More

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http://dx.doi.org/10.1080/17446651.2019.1575726DOI Listing

Cell membrane capsule: a novel natural tool for antitumour drug delivery.

Expert Opin Drug Deliv 2019 Mar 7;16(3):251-269. Epub 2019 Mar 7.

c People's Hospital of Hangzhou Medical College , Hangzhou , Zhejiang Province , China.

Introduction: Chemotherapy plays an important role in antitumour therapy, but causes serious adverse reactions. So, drug delivery system (DDS) with cell-targeting ability is an important method to reduce adverse reactions while ensuring the effectiveness of chemotherapy. Synthetic drug carriers and DDSs based on cells have proven safety and efficacy, but they also have many deficiencies or limitations. Read More

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http://dx.doi.org/10.1080/17425247.2019.1581762DOI Listing
March 2019
4 Reads

Future perspectives of the pharmacological management of diabetic dyslipidemia.

Expert Rev Clin Pharmacol 2019 Feb 22;12(2):129-143. Epub 2019 Jan 22.

c Division of Endocrinology , Diabetes and Metabolism University of South Carolina School of Medicine Columbia , South Carolina , SC , USA.

Introduction: Diabetic dyslipidemia is frequent among patients with type 2 diabetes mellitus (T2DM) and is characterized by an increase in triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and small-dense (atherogenic) particles, and by a decrease in low high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (Apo) A1 that are strongly related to insulin resistance. The increased flux of free fatty acids from adipose tissue to the liver aggravates hepatic insulin resistance and promotes all of aspects of the dyslipidemic state. Areas covered: Statins are the first-line agents for treatment while other lipid-lowering drugs (ezetimibe, fibrate and proprotein convertase subtilisin/kexin type 9) or novel anti-diabetic agents (dipeptidyl peptidase-4 inhibitors (DPP-4is), glucagon like peptide-1 receptor agonist (GLP-1RA), sodium/glucose cotransporter 2 inhibitors (SGLT2is)) or nutraceuticals (berberine, omega 3 fatty acid, red yeast rice) can be used alone or in combination. Read More

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1567328DOI Listing
February 2019
16 Reads

Treating obesity in patients with cardiovascular disease: the pharmacotherapeutic options.

Expert Opin Pharmacother 2019 Apr 7;20(5):585-593. Epub 2019 Jan 7.

b Division of Endocrinology, Diabetes & Metabolism, Weill Cornell Medicine , Comprehensive Weight Control Center , New York , NY , USA.

Introduction: Obesity is a growing health problem that has numerous comorbidities, including cardiovascular disease (CVD). The multi-disciplinary treatment of obesity now includes the use of pharmacotherapy. When treating patients with obesity and CVD, certain medications may be more appropriate than others. Read More

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http://dx.doi.org/10.1080/14656566.2018.1561867DOI Listing
April 2019
1 Read

Management of hyponatremia: causes, clinical aspects, differential diagnosis and treatment.

Authors:
Alessandro Peri

Expert Rev Endocrinol Metab 2019 Jan 31;14(1):13-21. Epub 2018 Dec 31.

a Sodium Unit, Endocrinology, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio' , University of Florence, Careggi University Hospital , Florence , Italy.

Introduction: Hyponatremia is the most frequent electrolyte disorder in hospitalised patients. Acute and severe hyponatremia may be a life-threatening situation. However, also mild and chronic hyponatremia may negatively affect the health status (i. Read More

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http://dx.doi.org/10.1080/17446651.2019.1556095DOI Listing
January 2019
2 Reads

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits.

Stem Cell Investig 2018 14;5:40. Epub 2018 Nov 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: There is a general agreement that to ensure promising results of stem cell therapy in patients with diabetes, one must first understand its risks and benefits; thus, if the risk is sufficiently low along with many benefits, it can lead to developing a novel therapeutic approach based on sound science.

Methods: A systematic review and meta-analysis was performed using all available clinical trials to determine the benefits and risks associated with stem cell therapy in patients with diabetes (both T1DM and T2DM). An extensive search was conducted across several databases using all MeSH words regarding stem cell therapy and diabetes. Read More

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http://dx.doi.org/10.21037/sci.2018.11.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286886PMC
November 2018
3 Reads

Surgical-pharmacological interactions in the treatment of acromegaly.

Expert Rev Endocrinol Metab 2019 Jan 29;14(1):35-42. Epub 2018 Dec 29.

c Experimental Endocrinology Unit , Hospital de Especialidades, Centro Medico Nacional S. XXI, IMSS , Mexico City , Mexico.

Introduction: Acromegaly requires a multimodal treatment approach that includes surgery by an expert pituitary neurosurgeon, pharmacological treatment with one or more of the available drugs and radiation therapy. These treatment alternatives are not mutually exclusive but rather complement each other when properly indicated in the individual patient. In this review, we summarize and analyze the available data concerning the choice of the surgical approach (microscopy vs. Read More

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http://dx.doi.org/10.1080/17446651.2019.1559729DOI Listing
January 2019
2 Reads

Top-down and bottom-up control of stress-coping.

J Neuroendocrinol 2019 Mar 1;31(3):e12675. Epub 2019 Feb 1.

Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.

In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic-prefrontocortical circuitry during stress-coping. This action of the stress hormone is mediated by mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that are co-expressed abundantly in these higher brain regions. Via both receptor types, the glucocorticoids demonstrate, in various contexts, rapid nongenomic and slower genomic actions that coordinate consecutive stages of information processing. Read More

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http://dx.doi.org/10.1111/jne.12675DOI Listing
March 2019
1 Read

Management of immune-related adverse events resulting from immune checkpoint blockade.

Expert Rev Anticancer Ther 2019 Mar 9;19(3):209-222. Epub 2019 Jan 9.

a Dermatology Department , Saint-Louis Hospital , Paris , France.

Introduction: Immune checkpoint inhibitors (ICI) are now a standard of care in the treatment of many cancers leading to durable responses in patients with metastatic disease. These agents are generally well tolerated but may lead to the occurrence of immune-related adverse events (irAEs). As any organ may be affected, clinicians should be aware of the broad range of clinical manifestations and symptoms and keep in mind that toxicities may occur late, at any point along a patient's treatment course. Read More

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http://dx.doi.org/10.1080/14737140.2019.1562342DOI Listing
March 2019
4 Reads

Improving the rates of Aspergillus detection: an update on current diagnostic strategies.

Expert Rev Anti Infect Ther 2019 01 17;17(1):39-50. Epub 2018 Dec 17.

d Division of Infectious Diseases, Department of Medicine , University of California-San Diego , San Diego , CA , USA.

Introduction: The spectrum of disease caused by Aspergillus spp. is dependent on the immune system of the host, and ranges from invasive aspergillosis (IA) to chronic pulmonary aspergillosis (CPA). Early and reliable diagnosis of Aspergillus disease is important to decrease associated morbidity and mortality. Read More

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http://dx.doi.org/10.1080/14787210.2018.1558054DOI Listing
January 2019
3 Reads

Mipomersen and its use in familial hypercholesterolemia.

Expert Opin Pharmacother 2019 Feb 10;20(2):127-131. Epub 2018 Dec 10.

a Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine , Washington University School of Medicine , St. Louis , MO , USA.

Introduction: Familial Hypercholesterolemia (FH) is an inherited disorder characterized by a defect in the binding and internalization of low-density lipoprotein (LDL) particles, resulting in markedly elevated LDL levels and premature atherosclerosis. It is one of the most common inherited disorders of lipid metabolism. Many FH patients, especially those with homozygous FH do not reach LDL goals with traditional LDL therapies and may require additional, less often used, therapies. Read More

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http://dx.doi.org/10.1080/14656566.2018.1550071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438693PMC
February 2019
3 Reads

Approach to Using Trend Arrows in the FreeStyle Libre Flash Glucose Monitoring Systems in Adults.

J Endocr Soc 2018 Dec 14;2(12):1320-1337. Epub 2018 Nov 14.

Endocrine Society, Washington, District of Columbia.

The use of personal continuous glucose monitoring (CGM) has expanded dramatically among individuals with diabetes. CGM systems provide retrospective data, as well as the current glucose value and trend arrow data, which indicate the direction and velocity of changing glucose. In 2017, Aleppo and colleagues developed a simplified approach for adults with diabetes to safely adjust rapid-acting insulin doses using trend arrow information in the Dexcom G5 CGM system. Read More

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https://academic.oup.com/jes/article/2/12/1320/5181247
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http://dx.doi.org/10.1210/js.2018-00294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243139PMC
December 2018
32 Reads

Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.

BMJ 2018 11 21;363:k4644. Epub 2018 Nov 21.

Toronto 3D (Diet, Digestive Tract, and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, 61 Queen Street East, Toronto, ON, M5C 2T2, Canada

Objective: To assess the effect of different food sources of fructose-containing sugars on glycaemic control at different levels of energy control.

Design: Systematic review and meta-analysis of controlled intervention studies.

Data Sources: Medine, Embase, and the Cochrane Library up to 25 April 2018. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247175PMC
http://dx.doi.org/10.1136/bmj.k4644DOI Listing
November 2018
15 Reads

A multistep approach for the stratification of the risk of severe hypoglycemia in patients with type 2 diabetes.

Minerva Endocrinol 2018 Dec;43(4):501-510

Department of Endocrinology and Metabolic Diseases, Aldo Moro University, Bari, Italy.

Introduction: Hypoglycemia is the major limiting factor in the glycemic management of diabetes. Aim of this study was to produce a risk stratification tool to support the medical decision making, by facilitating the identification of patients at higher risk of hypoglycemia.

Evidence Acquisition: A multistep approach was adopted, including a systematic review of observational studies investigating risk factors for severe hypoglycemia in type 2 diabetes (T2DM), followed by an expert input forum to identify factors perceived as relevant and at the same time reliably detectable, to be used for the development of a risk score. Read More

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http://dx.doi.org/10.23736/S0391-1977.18.02850-XDOI Listing
December 2018
17 Reads

Links between HPA axis and adipokines: clinical implications in paradigms of stress-related disorders.

Expert Rev Endocrinol Metab 2018 11 13;13(6):317-332. Epub 2018 Nov 13.

a Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, School of Medicine , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated by hormones of the HPA axis such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids (GCs) and adipokines secreted by the adipose tissue.

Areas Covered: In this critical review, the bi-directional interactions between HPA axis and the most studied adipokines such as leptin and adiponectin, as well as the pro-inflammatory adipocytokines tumor necrosis factor (TNF) and interleukin (IL) 6 are presented. Read More

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https://www.tandfonline.com/doi/full/10.1080/17446651.2018.1
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http://dx.doi.org/10.1080/17446651.2018.1543585DOI Listing
November 2018
19 Reads

Pharmacoeconomic evaluation of sodium-glucose transporter-2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Expert Opin Pharmacother 2019 Feb 9;20(2):151-161. Epub 2018 Nov 9.

c Division of Endocrinology, Diabetes and Nutrition , University of Maryland School of Medicine , Baltimore , MD , USA.

Introduction: Clinicians have many safe and effective options for the treatment of type 2 diabetes that can improve glycemic control and effect other cardio-metabolic parameters. Sodium-glucose transporter-2 inhibitors (SGLT-2) are the most recent class of therapies, have a novel mechanism of action, and provide good glycemic efficacy and a favorable cardiovascular risk profile. Cost-effectiveness data can play an important role in assessing the benefits of this class of therapy in anti-diabetes treatment regimens. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1543408DOI Listing
February 2019
8 Reads

Growth failure in Crohn's disease children: may the first treatment have a role?

Expert Rev Clin Immunol 2018 Nov 7:1-8. Epub 2018 Nov 7.

a Artificial Nutrition Unit , "Bambino Gesù" Children Hospital , Rome , Italy.

Introduction: Growth failure in children is a frequent feature of childhood-onset Crohn's disease (CD), and stunting can persist into adulthood. Growth is an important outcome by which to judge the effectiveness of therapies in children; currently available studies in CD children have focused on the short-term impact of treatments on growth, and there are limited data regarding the long-term effects of treatments upon growth. Areas covered: We designed the present article to review whether the first treatment performed in newly diagnosed CD children may have a role on the future growth course. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1543590DOI Listing
November 2018
9 Reads

Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review.

Mod Pathol 2019 Apr 6;32(4):546-559. Epub 2018 Nov 6.

Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, UCBL Lyon 1 University, Lyon, France.

The prognosis of malignant pediatric adrenocortical tumors is closely related to disease stage, which is used to guide perioperative treatment recommendations. However, current scoring systems are inadequate to distinguish between benign and malignant adrenocortical tumors. Robust microscopic prognostic features that could help determine perioperative therapy are also lacking. Read More

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http://www.nature.com/articles/s41379-018-0174-8
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http://dx.doi.org/10.1038/s41379-018-0174-8DOI Listing
April 2019
12 Reads
6.190 Impact Factor

Modern management of recurrent miscarriage.

Aust N Z J Obstet Gynaecol 2019 Feb 4;59(1):36-44. Epub 2018 Nov 4.

Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

Recurrent miscarriage (RM), also known as recurrent pregnancy loss, is a distressing condition affecting around 1% of couples trying to conceive It can be very frustrating for both clinicians and patients as, despite intensive workup, no clear underlying pathology is forthcoming in at least 50% of couples. This leads to despair for patients and leaves clinicians at a loss for how to help. Desperation in both camps can promote the uptake of investigations and interventions of unproven benefit. Read More

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http://doi.wiley.com/10.1111/ajo.12920
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http://dx.doi.org/10.1111/ajo.12920DOI Listing
February 2019
15 Reads

Expert Opinion: Patient Selection for Premixed Insulin Formulations in Diabetes Care.

Diabetes Ther 2018 Dec 3;9(6):2185-2199. Epub 2018 Nov 3.

Institute for Studies on Diabetes Foundation Inc, Marikina City, Philippines.

Premixed insulins are an important tool for glycemic control in persons with diabetes. Equally important in diabetes care is the selection of the most appropriate insulin regimen for a particular individual at a specific time. Currently, the choice of insulin regimens for initiation or intensification of therapy is a subjective decision. Read More

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http://link.springer.com/10.1007/s13300-018-0521-2
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http://dx.doi.org/10.1007/s13300-018-0521-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250631PMC
December 2018
28 Reads

Clinical profiles and risk assessment in patients with antiphospholipid antibodies.

Expert Rev Clin Immunol 2019 01 13;15(1):73-81. Epub 2018 Nov 13.

a Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.

Introduction: Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia associated with the presence of persistent antiphospholipid antibodies (aPL). Owing to recent studies, not only APS patients but also incidentally-identified, asymptomatic aPL carriers are able to be stratified in terms of the risk of future thrombotic events, according to the variety and the titer of positive aPL tests and to the non-thrombotic, aPL-associated clinical manifestations. Areas covered: Here, we critically review (1) criteria manifestations of APS, (2) non-criteria manifestations of APS, (3) risk assessment in patients with APS and in aPL carriers, and (4) the potential role of primary thrombosis prophylaxis in aPL carriers. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1543025DOI Listing
January 2019
4 Reads

Investigational drugs in early stage clinical trials for thyrotoxicosis with hyperthyroidism.

Expert Opin Investig Drugs 2018 11 31;27(11):831-837. Epub 2018 Oct 31.

a Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Endocrinology Department , Hospital Universitario de Bellvitge , Barcelona , Spain.

Introduction: Thyrotoxicosis with hyperthyroidism is treated with these classical approaches (i) antithyroid drugs to blockade thyroid hormone release and normalize thyroid hormone production and (ii) destruction of the thyroid using radioiodine or surgical removal of the thyroid. The optimal medical therapy, especially for Graves´ disease, remains a subject of debate and there has been little progress in Graves' disease therapeutics over the last decade.

Areas Covered: Novel treatments of thyrotoxicosis with hyperthyroidism. Read More

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https://www.tandfonline.com/doi/full/10.1080/13543784.2018.1
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http://dx.doi.org/10.1080/13543784.2018.1541086DOI Listing
November 2018
33 Reads

JCL roundtable: High-density lipoprotein function and reverse cholesterol transport.

J Clin Lipidol 2018 Sep - Oct;12(5):1086-1094. Epub 2018 Oct 9.

Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address:

High-density lipoproteins (HDL) have been known since the 1960s to be associated with protection from atherosclerotic cardiovascular disease. However, the mechanisms of this protection are unclear. The extent to which HDL per se vs other correlated metabolic factors may mitigate atherosclerosis has been seriously questioned. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19332874183038
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http://dx.doi.org/10.1016/j.jacl.2018.09.005DOI Listing
October 2018
14 Reads

Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques-A Literature Review.

Adv Ther 2018 Nov 11;35(11):1805-1815. Epub 2018 Oct 11.

Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.

Polycystic ovary syndrome (PCOS) affects 6-10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin resistance and hyperandrogenism, which play a severe detrimental role in the patient's fertility. We aimed to offer an overview about drug metabolism in the PCOS population. Read More

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http://link.springer.com/10.1007/s12325-018-0810-1
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http://dx.doi.org/10.1007/s12325-018-0810-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224003PMC
November 2018
5 Reads
2.440 Impact Factor

Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up.

Expert Rev Neurother 2018 Oct 4;18(10):793-806. Epub 2018 Oct 4.

a Department of Pediatrics and Pediatric Hematology/Oncology , Klinikum Oldenburg AöR, Medical Campus University Oldenburg , Oldenburg , Germany.

Introduction: Childhood-onset craniopharyngiomas are rare embryonic tumors of low-grade histological malignancy. Severe obesity, physical fatigue, and psychosocial deficits due to hypothalamic tumor involvement have negative impact on quality of life. Initial pretreatment involvement of hypothalamic structures and/or treatment-related lesions result in sequelae clinically associated with impaired social and physical functionality and severe neuroendocrine deficiencies. Read More

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http://dx.doi.org/10.1080/14737175.2018.1528874DOI Listing
October 2018
4 Reads

Skin and diabetes: an experts' opinion from the Italian diabetologists and dermatologists of the DiaDex group.

G Ital Dermatol Venereol 2018 Oct;153(5):649-658

Unit of Dermatology, Sant'Antonio Abate Hospital, Trapani, Italy.

The metabolic changes associated with diabetes mellitus (DM) affect a variety of organs and systems, including the skin. Skin lesions are frequently observed in patients with DM, resulting from a complex interaction among biochemical, vascular, immune, and metabolic changes. Cutaneous manifestations may develop at any time in the course of DM. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.06080-7DOI Listing
October 2018
5 Reads
0.491 Impact Factor

Should the last be first? Questions and dilemmas regarding early short-term insulin treatment in Type 2 Diabetes Mellitus.

Expert Opin Biol Ther 2018 11 25;18(11):1113-1121. Epub 2018 Sep 25.

a Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki , AHEPA University Hospital , Thessaloniki , Greece.

Introduction: Early short-term insulin treatment (STIT), defined as insulin administration shortly after diabetes diagnosis for only a brief period of time, is an alternative concept, aiming to entirely revise the perspective of type 2 diabetes (T2DM) management. Areas covered: The present review intends to summarize what is already known regarding early STIT in T2DM and highlight questions and dilemmas from the clinician's point of view, with a discourse on future research agenda. Expert opinion: STIT has the potential to modify the natural history of T2DM, resulting in improved drug-free remission rates by favorably affecting the underlying pathophysiology of the disease. Read More

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http://dx.doi.org/10.1080/14712598.2018.1526278DOI Listing
November 2018
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Untargeted metabolomics: an overview of its usefulness and future potential in prenatal diagnosis.

Expert Rev Proteomics 2018 10 4;15(10):809-816. Epub 2018 Oct 4.

d Centre for Metabolomics and Bioanalysis (CEMBIO), Facultad de Farmacia , Universidad CEU San Pablo , Madrid , Spain.

Introduction: Metabolomics opens up new avenues for biomarker discovery in different branches of medicine, including perinatology. Chromosomal aberration, preterm delivery (PTD), congenital heart defects, spina bifida, chorioamnionitis, and low birth weight are the main perinatal pathologies. Investigations using untargeted metabolomics have found the candidate metabolites for diagnostic biomarkers. Read More

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http://dx.doi.org/10.1080/14789450.2018.1526678DOI Listing
October 2018
4 Reads

Mini-review of hair cortisol concentration for evaluation of Cushing syndrome.

Expert Rev Endocrinol Metab 2018 09 20;13(5):225-231. Epub 2018 Sep 20.

c Section on Endocrinology and Genetics , Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda , MD , USA.

Introduction: The diagnosis of endogenous Cushing syndrome is often challenging and requires multiple repeated blood, urine, and saliva tests to detect elevated cortisol levels. Hair cortisol concentration has been described as a marker of long-term exposure to systemic cortisol in patients with Cushing syndrome. Like hemoglobin A1c is used to detect serum glucose exposure over months, segmental hair cortisol can help identify patients with milder forms of and/or periodic or cyclical Cushing syndrome, which may reduce time and costs associated with collection of urine, salivary, and serum cortisol. Read More

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https://www.tandfonline.com/doi/full/10.1080/17446651.2018.1
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http://dx.doi.org/10.1080/17446651.2018.1517043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378952PMC
September 2018
19 Reads

The effect of meals on bone turnover - a systematic review with focus on diabetic bone disease.

Expert Rev Endocrinol Metab 2018 09 20;13(5):233-249. Epub 2018 Sep 20.

b Steno Diabetes Center North Jutland , Aalborg University Hospital , Denmark.

Introduction: Type 2 diabetes is associated with an increased risk of bone fractures. Bone mineral density (BMD) is increased and bone turnover is low in type 2 diabetes and the increased BMD does not explain the increased fracture risk. However, the low bone turnover may lead to insufficient bone renewal with unrepaired micro-cracks and thus increase fracture risk. Read More

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http://dx.doi.org/10.1080/17446651.2018.1518131DOI Listing
September 2018
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Indications for islet or pancreatic transplantation: Statement of the TREPID working group on behalf of the Société francophone du diabète (SFD), Société francaise d'endocrinologie (SFE), Société francophone de transplantation (SFT) and Société française de néphrologie - dialyse - transplantation (SFNDT).

Diabetes Metab 2018 Sep 14. Epub 2018 Sep 14.

University of Lille, Inserm, CHU de Lille, UMR 1190, translational research in diabetes, endocrine surgery, 59000 Lille, France; CHU Lille, Endocrinology, diabetology and metabolism, 59000 Lille, France. Electronic address:

While either pancreas or pancreatic islet transplantation can restore endogenous insulin secretion in patients with diabetes, no beta-cell replacement strategies are recommended in the literature. For this reason, the aim of this national expert panel statement is to provide information on the different kinds of beta-cell replacement, their benefit-risk ratios and indications for each type of transplantation, according to type of diabetes, its control and association with end-stage renal disease. Allotransplantation requires immunosuppression, a risk that should be weighed against the risks of poor glycaemic control, diabetic lability and severe hypoglycaemia, especially in cases of unawareness. Read More

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http://dx.doi.org/10.1016/j.diabet.2018.07.006DOI Listing
September 2018
1 Read

Diagnostic procedure in suspected Graves' disease.

Ann Endocrinol (Paris) 2018 Dec 18;79(6):608-617. Epub 2018 Aug 18.

Service d'endocrinologie, CHU de Rabat, Rabat, Morocco.

Diagnostic procedure in suspected Graves' disease has never been studied scientifically and actual practice seems quite variable, notably between countries. Recommendations are few and weak (expert opinion). This article presents the recommendations of an expert consensus meeting organized by the French Society of Endocrinology in 2016. Read More

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http://dx.doi.org/10.1016/j.ando.2018.08.002DOI Listing
December 2018
1 Read

Treatment of adult Graves' disease.

Ann Endocrinol (Paris) 2018 Dec 16;79(6):618-635. Epub 2018 Aug 16.

Service de médecine nucléaire, Inserm U970, Sorbonne université, groupe hospitalier Pitié-Salpétrière, 75013 Paris, France.

Treatment strategy in Graves' disease firstly requires recovery of euthyroid status by antithyroid therapy. Treatment modalities, precautions, advantages and side-effects are to be discussed with the patient. No particular treatment modality has demonstrated superiority. Read More

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http://dx.doi.org/10.1016/j.ando.2018.08.003DOI Listing
December 2018
7 Reads

Obstructive sleep apnoea syndrome in patients living with diabetes: Which patients should be screened?

Diabetes Metab 2019 Apr 3;45(2):91-101. Epub 2018 Sep 3.

Angers university hospital, department of respiratory diseases, 49000 Angers, France; Angers university, Inserm UMR 1063, 49000 Angers, France.

Aim: Because type 2 diabetes (T2D) is related to obesity, it is often associated with obstructive sleep apnoea syndrome (OSAS), although OSAS is also frequently diagnosed in patients with type 1 diabetes (T1D) and may promote gestational diabetes. Thus, this systematic review of the scientific evidence aimed to evaluate the epidemiological association between OSAS and all forms of diabetes, the current understanding of the pathophysiological mechanisms behind these associations, the expected benefits and limitations of OSAS treatment in patients with diabetes and, finally, to propose which patients require screening for OSAS.

Methods: A panel comprising French expert endocrinologists and pneumologists was convened. Read More

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http://dx.doi.org/10.1016/j.diabet.2018.08.006DOI Listing
April 2019
12 Reads

Obesity in the global haemophilia population: prevalence, implications and expert opinions for weight management.

Obes Rev 2018 11 6;19(11):1569-1584. Epub 2018 Sep 6.

Division of Haematology, Haemostasis and Thrombosis Unit, Haemophilia Clinic, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Overweight and obesity may carry a significant disease burden for patients with haemophilia (PWH), who experience reduced mobility due to joint inflammation, muscle dysfunction and haemophilic arthropathy. This review aimed to define the prevalence and clinical impact of overweight/obesity in the global population of PWH. A detailed literature search pertaining to overweight/obesity in haemophilia in the last 15 years (2003-2018) was conducted, followed by a meta-analysis of epidemiological data. Read More

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http://dx.doi.org/10.1111/obr.12746DOI Listing
November 2018
9 Reads

Familial Chylomicronemia Syndrome: A Clinical Guide For Endocrinologists.

Authors:
James M Falko

Endocr Pract 2018 08;24(8):756-763

Objective: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder caused by mutations in lipoprotein lipase, resulting in accumulation of chylomicrons in plasma and hypertriglyceridemia. Elevated triglycerides cause several complications in patients, the most serious being episodes of acute pancreatitis. This review focuses on expert guidance and opinion from an experienced lipidologist and endocrinologist as well as a current review of the literature, as there are no specific guidelines on FCS. Read More

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http://dx.doi.org/10.4158/EP-2018-0157DOI Listing
August 2018
4 Reads